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JOURNAL ARTICLE
Laura Rojas, Marcel van de Wouw, Yanan Wang, Elnaz Vaghef-Mehrabani, Deborah Dewey, Raylene A Reimer, Nicole Letourneau, Tavis Campbell, Marie-Claire Arrieta, Gerald F Giesbrecht
OBJECTIVE: Stress is common among pregnant individuals and is associated with an altered gut microbiota composition in infants. It is unknown if these compositional changes persist into the preschool years when the gut microbiota reaches an adult-like composition. This study aimed to investigate if indicators of prenatal stress (i.e., psychological distress and stress-related physiology) are associated with children's gut microbiota composition and metabolites at 3-4 years of age. METHODS: Maternal-child pairs (n = 131) were from the Alberta Pregnancy Outcomes and Nutrition (APrON) cohort...
September 9, 2023: Psychoneuroendocrinology
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JOURNAL ARTICLE
Alejandro Cáceres, Natàlia Carreras-Gallo, Sandra Andrusaityte, Mariona Bustamante, Ángel Carracedo, Leda Chatzi, Varun B Dwaraka, Regina Grazuleviciene, Kristine Bjerve Gutzkow, Johanna Lepeule, Léa Maitre, Tavis L Mendez, Mark Nieuwenhuijsen, Remy Slama, Ryan Smith, Nikos Stratakis, Cathrine Thomsen, Jose Urquiza, Hannah Went, John Wright, Tiffany Yang, Maribel Casas, Martine Vrijheid, Juan R González
BACKGROUND: Obesity and neurodevelopmental delay are complex traits that often co-occur and differ between boys and girls. Prenatal exposures are believed to influence children's obesity, but it is unknown whether exposures of pregnant mothers can confer a different risk of obesity between sexes, and whether they can affect neurodevelopment. METHODS: We analyzed data from 1044 children from the HELIX project, comprising 93 exposures during pregnancy, and clinical, neuropsychological, and methylation data during childhood (5-11 years)...
April 12, 2023: BMC Medicine
#3
JOURNAL ARTICLE
Sacha Vignieri, Jennifer Sills, Jeffrey Mervis, Caroline Ash, Marc S Lavine, Seth Thomas Scanlon, Yevgeniya Nusinovich, Michael A Funk, Pamela J Hines, Valerie Thompson, Megan Engel, Adrian Cho, Victoria Arbour
No abstract text is available yet for this article.
December 9, 2022: Science
#4
JOURNAL ARTICLE
Dwight M Robertson, Dana M Boucek, Mary Hunt Martin, Robert G Gray, Eric R Griffiths, Aaron W Eckhauser, Zhining Ou, Linda M Lambert, Richard V Williams, S Adil Husain
Transcatheter aortic valve implantation (TAVI) is common in adults but rare in children and adolescents. Since 2014, our institution has incorporated a transcatheter approach as an option for aortic valve replacement in this population. The purpose of this study was to compare short-term outcomes of TAVI with surgical aortic valve replacement (SAVR). This single-center, retrospective study included patients aged 10 to 21 years who had a native SAVR or TAVI between January 2010 to April 2020. Comparative analysis of baseline characteristics and a composite outcome (stroke within 6 months, readmission within 30 days, death) between SAVR and TAVI were made using chi-square test or Wilcoxon rank sum test, as appropriate...
August 15, 2022: American Journal of Cardiology
#5
JOURNAL ARTICLE
Tavis Dickerson-Young, Neil G Uspal, William B Prince, Pingping Qu, Eileen J Klein
OBJECTIVES: There is limited research examining racial/ethnic disparities in antiemetic use for acute gastroenteritis (AGE). We assessed racial/ethnic differences in the care of children with AGE. METHODS: The Pediatric Health Information System was used to conduct a retrospective cohort study of children 6 months to 6 years old with AGE seen in participating emergency departments from 2016 to 2018. Cases were identified using International Classification of Diseases, Tenth Revision codes...
March 29, 2022: Pediatric Emergency Care
#6
JOURNAL ARTICLE
Anna L MacKinnon, Joshua W Madsen, Ashley Dhillon, Elizabeth Keys, Gerald F Giesbrecht, Tyler Williamson, Amy Metcalfe, Tavis Campbell, Kelly J Mrklas, Lianne Tomfohr-Madsen
BACKGROUND: Insomnia and sleep disturbances are common in pregnancy and have potentially significant consequences for both maternal and infant health. There is limited research examining the effectiveness of cognitive behavioral therapy for insomnia (CBT-I) during pregnancy. With increased distress and limited access to services during the COVID-19 pandemic, there is also an unprecedented need for telehealth delivery of treatment programs for pregnant women. The aims of this trial are to evaluate the impact of the Sleeping for Two adaptation of CBT-I in pregnancy (in-person or telehealth) versus treatment as usual (TAU) in reducing symptoms of insomnia (primary outcome), as well as increasing gestational length and reducing symptoms of depression (secondary outcomes)...
August 12, 2021: Trials
#7
JOURNAL ARTICLE
Tavis Dickerson-Young, Ashley Keilman, Hiromi Yoshida, Maya Jones, Nathan Cross, Anita Thomas
Introduction: Pediatric trauma management is a high-stress, high-risk, low-frequency event, and exposure through simulation can help identify and address knowledge gaps. Pediatric residents are likely to provide care for children with traumatic injuries, and it is important they are skilled in performing a rapid trauma assessment. Methods: We developed a simulation-based rapid pediatric trauma assessment curriculum for pediatric residents in the setting of a mass casualty disaster...
August 21, 2020: MedEdPORTAL Publications
#8
REVIEW
Doreen M Rabi, Kerry A McBrien, Ruth Sapir-Pichhadze, Meranda Nakhla, Sofia B Ahmed, Sandra M Dumanski, Sonia Butalia, Alexander A Leung, Kevin C Harris, Lyne Cloutier, Kelly B Zarnke, Marcel Ruzicka, Swapnil Hiremath, Ross D Feldman, Sheldon W Tobe, Tavis S Campbell, Simon L Bacon, Kara A Nerenberg, George K Dresser, Anne Fournier, Ellen Burgess, Patrice Lindsay, Simon W Rabkin, Ally P H Prebtani, Steven Grover, George Honos, Jeffrey E Alfonsi, JoAnne Arcand, François Audibert, Geneviève Benoit, Jesse Bittman, Peter Bolli, Anne-Marie Côté, Janis Dionne, Andrew Don-Wauchope, Cedric Edwards, Tabassum Firoz, Jonathan Y Gabor, Richard E Gilbert, Jean C Grégoire, Steven E Gryn, Milan Gupta, Fady Hannah-Shmouni, Robert A Hegele, Robert J Herman, Michael D Hill, Jonathan G Howlett, Gregory L Hundemer, Charlotte Jones, Janusz Kaczorowski, Nadia A Khan, Laura M Kuyper, Maxime Lamarre-Cliche, Kim L Lavoie, Lawrence A Leiter, Richard Lewanczuk, Alexander G Logan, Laura A Magee, Birinder K Mangat, Philip A McFarlane, Donna McLean, Andre Michaud, Alain Milot, Gordon W Moe, S Brian Penner, Andrew Pipe, Alexandre Y Poppe, Evelyne Rey, Michael Roerecke, Ernesto L Schiffrin, Peter Selby, Mike Sharma, Ashkan Shoamanesh, Praveena Sivapalan, Raymond R Townsend, Karen Tran, Luc Trudeau, Ross T Tsuyuki, Michel Vallée, Vincent Woo, Alan D Bell, Stella S Daskalopoulou
Hypertension Canada's 2020 guidelines for the prevention, diagnosis, risk assessment, and treatment of hypertension in adults and children provide comprehensive, evidence-based guidance for health care professionals and patients. Hypertension Canada develops the guidelines using rigourous methodology, carefully mitigating the risk of bias in our process. All draft recommendations undergo critical review by expert methodologists without conflict to ensure quality. Our guideline panel is diverse, including multiple health professional groups (nurses, pharmacy, academics, and physicians), and worked in concert with experts in primary care and implementation to ensure optimal usability...
May 2020: Canadian Journal of Cardiology
#9
JOURNAL ARTICLE
Gaëlle Bégo-Le Bagousse, Xiaoying Jia, Sorrel Wolowacz, Laurent Eckert, Jules Tavi, Richard Hudson
Objective: Health utility estimates for children and adolescents are critical for cost-utility analyses informing health technology assessment (HTA) authorities' decisions governing access to pediatric treatments. However, in a recent review, only 29% of published pediatric cost-utility models used a utility measure validated for children. We examined utility estimates used in pediatric HTAs. Methods: A targeted review of pediatric HTAs was performed, focusing on agencies reporting utility estimate sources and methods...
April 29, 2020: Current Medical Research and Opinion
#10
JOURNAL ARTICLE
Jenna C Thomas-Argyriou, Nicole Letourneau, Deborah Dewey, Tavis S Campbell, Gerald F Giesbrecht
The current study aimed to understand the mediating and/or moderating role of prenatal hypothalamic-pituitary-adrenal (HPA) axis function in the association between maternal adverse childhood experiences (ACEs) and child internalizing and externalizing behavior problems at age 4. The influence of timing and child sex were also explored. Participants were 248 mother-child dyads enrolled in a prospective longitudinal cohort study (the Alberta Pregnancy Outcomes and Nutrition Study). Maternal ACEs were retrospectively assessed while maternal self-reported depression and diurnal salivary cortisol were assessed prospectively at 6-26 weeks gestation (T1) and 27-37 weeks gestation (T2)...
March 3, 2020: Development and Psychopathology
#11
JOURNAL ARTICLE
Elena Ali, Nicole Letourneau, Karen Benzies, Henry Ntanda, Deborah Dewey, Tavis Campbell, Gerry Giesbrecht
BACKGROUND: Prenatal anxiety is associated with child behavioral problems. Prenatal anxiety is predictive of postnatal anxiety which can interfere with the security of maternal-child attachment and further raise the risk of child behavior problems. Secure maternal-child attachment is essential for optimal emotional health. Sex influences the type of behavior problem experienced. There is a gap in understanding whether attachment security and the sex of the child can moderate association between prenatal anxiety and children's behavioral problems...
June 2020: Canadian Journal of Nursing Research
#12
JOURNAL ARTICLE
Anita Anne Thomas, Tavis Dickerson-Young, Suzan Mazor
BACKGROUND: Recreational marijuana became commercially available in Washington State in 2014. Children with marijuana intoxication can have lethargy and altered mental status, often resulting in extensive workup. OBJECTIVES: The aim of this study was to quantify the incidence of pediatric marijuana exposure before and after marijuana legalization/commercial availability in Washington State at a tertiary care children's hospital. METHODS: Charts of patients 9 years or younger evaluated at a tertiary care pediatric hospital from October 8, 2007, to October 31, 2016, were retrospectively reviewed...
December 27, 2018: Pediatric Emergency Care
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JOURNAL ARTICLE
Agnes van Sonderen, Samuel Arends, Dénes L J Tavy, Anna E M Bastiaansen, Marienke A A M de Bruijn, Marco W J Schreurs, Peter A E Sillevis Smitt, Maarten J Titulaer
OBJECTIVES: Anti-N-methyl-D-aspartate receptor encephalitis (anti-NMDARE) is a severe, but treatable disease. This study aims to give a detailed description of electroencephalogram (EEG) results in paediatric and adult patients to improve disease recognition, and analyses the predictive value of the first EEG for the final clinical outcome. METHODS: This nationwide cohort study includes patients with N-methyl-D-aspartate receptor antibodies confirmed with cell-based assay and immunohistochemistry in serum and cerebrospinal fluid...
October 2018: Journal of Neurology, Neurosurgery, and Psychiatry
#14
JOURNAL ARTICLE
Harald Breivik, Kari Sørensen, Øyvind Tavi
No abstract text is available yet for this article.
October 1, 2015: Scandinavian Journal of Pain
#15
JOURNAL ARTICLE
Kara A Nerenberg, Kelly B Zarnke, Alexander A Leung, Kaberi Dasgupta, Sonia Butalia, Kerry McBrien, Kevin C Harris, Meranda Nakhla, Lyne Cloutier, Mark Gelfer, Maxime Lamarre-Cliche, Alain Milot, Peter Bolli, Guy Tremblay, Donna McLean, Raj S Padwal, Karen C Tran, Steven Grover, Simon W Rabkin, Gordon W Moe, Jonathan G Howlett, Patrice Lindsay, Michael D Hill, Mike Sharma, Thalia Field, Theodore H Wein, Ashkan Shoamanesh, George K Dresser, Pavel Hamet, Robert J Herman, Ellen Burgess, Steven E Gryn, Jean C Grégoire, Richard Lewanczuk, Luc Poirier, Tavis S Campbell, Ross D Feldman, Kim L Lavoie, Ross T Tsuyuki, George Honos, Ally P H Prebtani, Gregory Kline, Ernesto L Schiffrin, Andrew Don-Wauchope, Sheldon W Tobe, Richard E Gilbert, Lawrence A Leiter, Charlotte Jones, Vincent Woo, Robert A Hegele, Peter Selby, Andrew Pipe, Philip A McFarlane, Paul Oh, Milan Gupta, Simon L Bacon, Janusz Kaczorowski, Luc Trudeau, Norman R C Campbell, Swapnil Hiremath, Michael Roerecke, Joanne Arcand, Marcel Ruzicka, G V Ramesh Prasad, Michel Vallée, Cedric Edwards, Praveena Sivapalan, S Brian Penner, Anne Fournier, Geneviève Benoit, Janusz Feber, Janis Dionne, Laura A Magee, Alexander G Logan, Anne-Marie Côté, Evelyne Rey, Tabassum Firoz, Laura M Kuyper, Jonathan Y Gabor, Raymond R Townsend, Doreen M Rabi, Stella S Daskalopoulou
Hypertension Canada provides annually updated, evidence-based guidelines for the diagnosis, assessment, prevention, and treatment of hypertension in adults and children. This year, the adult and pediatric guidelines are combined in one document. The new 2018 pregnancy-specific hypertension guidelines are published separately. For 2018, 5 new guidelines are introduced, and 1 existing guideline on the blood pressure thresholds and targets in the setting of thrombolysis for acute ischemic stroke is revised. The use of validated wrist devices for the estimation of blood pressure in individuals with large arm circumference is now included...
May 2018: Canadian Journal of Cardiology
#16
JOURNAL ARTICLE
Yukiko Mizutani, Norio Tada, Takahiko Masuda, Masaki Hata
Coarctation of the aorta (CoA) is a relatively common congenital heart anomaly, and bicuspid aortic valve (BAV) is a common congenital heart disease that coexists with CoA. In larger children and adults with CoA, transcatheter intervention has gained acceptance, but for surgical high-risk patients with aortic stenosis, the use of transcatheter aortic valve implantation (TAVI) has been established. Recently, although favorable data have been reported for TAVI when treating BAV, simultaneous transcatheter intervention for CoA and BAV will prove to be a challenge because of the unique anatomy involved requires multiple procedural steps and also has problems of site access...
July 2017: Journal of Heart Valve Disease
#17
JOURNAL ARTICLE
Tavis J Glassman, Tom Castor, Monita Karmakar, Alexis Blavos, Paige Dagenhard, Julianne Domigan, Erin Sweeney, Aaron Diehr, Ruthie Kucharewski
BACKGROUND: Water-related injuries and fatalities pose serious public health issues, especially to African American youth, a demographic group that drowns at disproportionately high rates. AIM: The purpose of this study was to determine if a social marketing intervention targeting the parents and guardians of inner-city youth (U.S. Midwest) could positively influence their perceptions concerning water safety. METHOD: Researchers employed a quasi-experimental design using matched pairs to evaluate the intervention...
March 2018: Health Promotion Practice
#18
REVIEW
Julian Koenig, Joshua A Rash, Tavis S Campbell, Julian F Thayer, Michael Kaess
Lower vagal activity is associated with psychopathology independent of age. Research suggests that alterations of vagal activity precede the development of psychopathology. The present review aimed to quantify sex differences in vagal activity in children and adolescents. Studies reporting on sex differences on measures of vagally-mediated heart rate variability derived from short-term recordings under resting conditions in boys and girls were included. Drawing on data from more than 5,000 children and adolescents, we provide evidence that healthy young girls display lower vagal activity and greater mean heart rate compared to boys, a finding that may have implications for risk associated with the development of internalizing psychopathology and somatic ill-health...
2017: Frontiers in Physiology
#19
JOURNAL ARTICLE
Loss of Cln5 causes altered neurogenesis in a mouse model of a childhood neurodegenerative disorder.
Ekaterina Savchenko, Yajuvinder Singh, Henna Konttinen, Katarina Lejavova, Laura Mediavilla Santos, Alexandra Grubman, Virve Kärkkäinen, Velta Keksa-Goldsteine, Nikolay Naumenko, Pasi Tavi, Anthony R White, Tarja Malm, Jari Koistinaho, Katja M Kanninen
Neural stem/progenitor cells (NPCs) generate new neurons in the brain throughout an individual's lifetime in an intricate process called neurogenesis. Neurogenic alterations are a common feature of several adult-onset neurodegenerative diseases. The neuronal ceroid lipofuscinoses (NCLs) are the most common group of inherited neurodegenerative diseases that mainly affect children. Pathological features of the NCLs include accumulation of lysosomal storage material, neuroinflammation and neuronal degeneration, yet the exact cause of this group of diseases remains poorly understood...
September 1, 2017: Disease Models & Mechanisms
#20
JOURNAL ARTICLE
Gerald F Giesbrecht, Maede Ejaredar, Jiaying Liu, Jenna Thomas, Nicole Letourneau, Tavis Campbell, Jonathan W Martin, Deborah Dewey
BACKGROUND: Animal models show that prenatal bisphenol A (BPA) exposure leads to sexually dimorphic disruption of the neuroendocrine system in offspring, including the hypothalamic-pituitary-adrenal (HPA) neuroendocrine system, but human data are lacking. In humans, prenatal BPA exposure is associated with sex-specific behavioural problems in children, and HPA axis dysregulation may be a biological mechanism. The objective of the current study was to examine sex differences in associations between prenatal maternal urinary BPA concentration and HPA axis function in 3 month old infants...
May 19, 2017: Environmental Health
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