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https://www.readbyqxmd.com/read/28076334/establishment-of-a-normal-derived-estrogen-receptor-positive-cell-line-comparable-to-the-prevailing-human-breast-cancer-subtype
#1
Branden M Hopkinson, Marie C Klitgaard, Ole William Petersen, René Villadsen, Lone Rønnov-Jessen, Jiyoung Kim
Understanding human cancer increasingly relies on insight gained from subtype specific comparisons between malignant and non-malignant cells. The most frequent subtype in breast cancer is the luminal. By far the most frequently used model for luminal breast cancer is the iconic estrogen receptor-positive (ERpos) MCF7 cell line. However, luminal specific comparisons have suffered from the lack of a relevant non-malignant counterpart. Our previous work has shown that transforming growth factor-β receptor (TGFβR) inhibition suffices to propagate prospectively isolated ERpos human breast luminal cells from reduction mammoplasties (HBEC)...
January 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28062965/patient-satisfaction-and-clinical-outcomes-following-414-breast-reductions-application-of-breast-q
#2
A Cogliandro, M Barone, G Cassotta, S Tenna, B Cagli, P Persichetti
BACKGROUND: The aim of this study was to measure breast satisfaction and quality of life using the BREAST-Q Reduction Module in a large sample of postoperative patients having breast reduction using the inverted T technique. METHODS: With due approval from the ethics committee of our university, 414 patients who were seen in consultation for breast reduction surgery between 2005 and 2015 performed by the same team were asked to fill out BREAST-Q surveys. The patient factors collected for all those undergoing breast reduction included age, body mass index, incision pattern, areola complex pedicle used, amount of tissue resected, concurrent procedures, and complications...
January 7, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28062962/necrotizing-fasciitis-in-aesthetic-surgery-a-review-of-the-literature
#3
REVIEW
Andrea Marchesi, Stefano Marcelli, Pier C Parodi, Rosario E Perrotta, Michele Riccio, Luca Vaienti
INTRODUCTION: Necrotizing fasciitis (NF) is a rare, potentially fatal, infective complication that can occur after surgery. Diagnosis is still difficult and mainly based on clinical data. Only a prompt pharmacological and surgical therapy can avoid dramatic consequences. There are few reports regarding NF as a complication after aesthetic surgical procedures, and a systematic review still lacks. MATERIALS AND METHODS: We have performed a systematic review of English literature on PubMed, covering a period of 30 years...
January 7, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28052717/oncoplastic-surgery-volume-displacement-techniques-for-breast-conserving-surgery-in-patients-with-breast-cancer
#4
Gunay Gurleyik, Hikmet Karagulle, Esra Eris, Fugen Aker, Basak O Ustaalioglu
BACKGROUND: Surgical management of breast cancer has drastically changed. Breast-conserving surgery (BCS) has now become a commonly used method for its treatment. Oncoplastic techniques are widely applied with satisfactory aesthetic results. We evaluated the aesthetic and oncological outcomes of BCS with glandular tissue displacement techniques. METHODS: Seventy-five patients with invasive breast cancer were surgically treated by oncoplastic techniques. Preoperative evaluations, including breast and tumor size, localizations and features, were performed by physical examination, imaging methods, and histopathological analysis...
January 5, 2017: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/28032174/septum-inferior-medial-sim-based-pedicle-a-safe-pedicle-with-well-preserved-nipple-sensation-for-reduction-in-gigantomastia
#5
Ercan Karacaoglu, Richard J Zienowicz
BACKGROUND: Reduction in breasts with well-preserved nipple sensation and a viable nipple-areola complex (NAC) is one of the basic core concepts of reduction mammoplasty. Many techniques have been described with enthusiasm advocating full achievement of the aforementioned goals. The goal of this study is to introduce a novel technique that provides an intact neurovascular source to the nipple-areola complex for reduction in gigantic breasts. PATIENTS AND METHODS: Twenty-six patients operated on from December 2010 through April 2015 were included in the study...
December 28, 2016: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28030581/oncoplastic-surgery-for-upper-upper-inner-quadrant-breast-cancer
#6
Joseph Lin, Dar-Ren Chen, Yu-Fen Wang, Hung-Wen Lai
Tumors located in the upper/upper inner quadrant of the breast warrant more attention. A small lesion relative to the size of breast in this location may be resolved by performing a level I oncoplastic technique. However, a wide excision may significantly reduce the overall quality of the breast shape by distorting the visible breast line. From June 2012 to April 2015, 36 patients with breast cancer located in the upper/upper inner quadrant underwent breast-conservation surgery with matrix rotation mammoplasty...
2016: PloS One
https://www.readbyqxmd.com/read/28025622/a-comparison-of-barbed-sutures-and-standard-sutures-with-regard-to-wound-cosmesis-in-panniculectomy-and-reduction-mammoplasty-patients
#7
Kristen Aliano, Michael Trostler, Indira Michelle Fromm, Alexander Dagum, Sami Khan, Duc Bui
Cosmesis is a vital concern for patients undergoing plastic and reconstructive surgery. Many variations in wound closure are employed when attempting to minimize a surgical scar's appearance. Barbed sutures are one potential method of achieving improved wound cosmesis and are more common in recent years. To determine if barbed sutures differ from nonbarbed in wound cosmesis, we conducted a single-blinded, randomized, controlled trial of 18 patients undergoing bilateral reduction mammoplasty or panniculectomy...
2016: Plastic Surgery International
https://www.readbyqxmd.com/read/28008464/long-term-effects-of-the-collagenase-of-the-bacterium-clostridium-histolyticum-for-the-treatment-of-capsular-fibrosis-after-silicone-implants
#8
Sebastian Fischer, Yannick Diehm, Thomas Henzler, Martin R Berger, Jonas Kolbenschlag, Anne Latz, Ericka M Bueno, Christoph Hirche, Ulrich Kneser, Bohdan Pomahac
BACKGROUND: Capsular contracture remains the most frequent long-term complication after augmentation mammoplasty with silicone implants. Thereby, the main part of the fibrotic capsule is collagen. The collagenase of the bacterium Clostridium histolyticum is approved for the treatment of fibrotic diseases and has been demonstrated to be effective for capsular fibrosis treatment in the short term. However, long-term effectiveness is currently unknown but mandatory for clinical utilization...
December 23, 2016: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28002283/a-comparison-of-superomedial-versus-inferior-pedicle-reduction-mammoplasty-using-three-dimensional-analysis
#9
Antoine de Runz, Raphael Carloni, David Boccara, Farid Bekara, Nicolas Bertheuil
No abstract text is available yet for this article.
December 16, 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28002276/reply-superomedial-versus-inferior-pedicle-reduction-mammoplasty
#10
Victor Zhu, Stephanie Kwei
No abstract text is available yet for this article.
December 16, 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27940905/relationship-between-obesity-and-surgical-complications-after-reduction-mammaplasty-a-systematic-literature-review-and-meta-analysis
#11
Yujin Myung, Chan-Yeong Heo
BACKGROUND: Although many patients who undergo reduction mammaplasty are obese, reports on whether obesity is a risk factor for postoperative complications have been conflicting. OBJECTIVES: This systematic literature review and meta-analysis aimed to evaluate the relationship between obesity and surgical complications after reduction mammaplasty. METHODS: The PubMed, Medline, and Embase databases were searched between 1998 and 2016 using the MeSH terms and keywords "reduction mammoplasty (mammaplasty)," "breast reduction," "obesity," "body weight," "body mass index," and "risk factor...
December 9, 2016: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/27936188/risk-factors-for-complications-after-reduction-mammoplasty-a-meta-analysis
#12
Min-Xia Zhang, Chun-Ye Chen, Qing-Qing Fang, Ji-Hua Xu, Xiao-Feng Wang, Bang-Hui Shi, Li-Hong Wu, Wei-Qiang Tan
BACKGROUND: Reduction mammoplasty (RM) is a proven method of treating macromastia, but the risk factors for postoperative complications have not been clearly identified. Through this meta-analysis, the authors aimed to identify the risk factors of RM complications. METHODS: An extensive search of the literature describing complications after RM was performed using the PubMed Central, Embase, and Cochrane databases. The following risk factors were extracted: age, body mass index (BMI), tissue resection weight per breast (TRW), smoking and radiation therapy...
2016: PloS One
https://www.readbyqxmd.com/read/27908586/standard-wide-local-excision-or-bilateral-reduction-mammoplasty-in-large-breasted-women-with-small-tumours-surgical-and-patient-reported-outcomes
#13
R Di Micco, R L O'Connell, P A Barry, N Roche, F A MacNeill, J E Rusby
INTRODUCTION: Oncoplastic breast surgery is used to extend the role of breast-conserving surgery (BCS) to women with an unfavourable tumour to breast volume ratio. However, large-breasted women with a relatively small breast cancer may be offered bilateral reduction mammoplasty (BRM) despite being suitable for standard BCS as the more complex surgery may have advantages in terms of patient satisfaction and reduced adverse effects of radiotherapy. PATIENT AND METHODS: This retrospective study evaluated surgical and patient-reported outcome measures (PROMs) in large-breasted women with early (<3 cm) breast cancer, who have undergone unilateral standard BCS or BRM...
November 17, 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27899130/antibiotic-prophylaxis-in-reduction-mammaplasty-study-protocol-for-a-randomized-controlled-trial
#14
Edgard Silva Garcia, Daniela Francescato Veiga, Joel Veiga-Filho, Isaías Vieira Cabral, Natália Lana Larcher Pinto, Neil Ferreira Novo, Miguel Sabino Neto, Lydia Masako Ferreira
BACKGROUND: The role of antibiotics in surgical procedures where the risk of surgical site infection (SSI) is low remains uncertain. There is, to date, no evidence to justify the routine use of antibiotics in postoperative reduction mammaplasty. The aim of this study is to evaluate the effect of postoperative antibiotic treatment on the occurrence of SSI after breast reduction surgery. METHODS: This is a double-blind randomized clinical trial with 124 breast hypertrophy patients allocated to two treatment groups: antibiotic (n = 62) and placebo (n = 62)...
November 30, 2016: Trials
https://www.readbyqxmd.com/read/27861132/chronic-morel-lavall%C3%A3-e-lesion-a-novel-minimally-invasive-method-of-treatment
#15
Ramireddy Mettu, Harsha Vardhan Surath, Hanumantha Rao Chayam, Amaranth Surath
A Morel-Lavallée lesion is a closed internal degloving injury resulting from a shearing force applied to the skin. The etiology of this condition may be motor vehicle accidents, falls, contact sports (ie, football, wrestling),1 and iatrogenic after mammoplasty or abdominal liposuction.2 Common sites of the lesions include the pelvis and/or thigh.3 Isolated Morel-Lavallée lesions without underlying fracture are likely to be missed, which result in chronicity. Management of this condition often requires extensive surgical procedures such as debridement, sclerotherapy, serial percutaneous drainage, negative pressure wound therapy (NPWT), and skin grafting...
November 2016: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/27833284/long-term-follow-up-and-patient-satisfaction-after-reduction-mammoplasty-superomedial-versus-inferior-pedicle
#16
Mohamed Makboul, Mahmoud S Abdelhamid, Ghada S Al-Attar
BACKGROUND: Surgery for hypertrophied breasts represents a challenge for plastic surgeons. The search for a good post-surgical cosmetic breast has led to the development of many techniques. Objectives for reduction mammoplasty are to achieve elevated, symmetrical breasts, a round shape, good projection, small cicatrices that are not very perceptible, and a lasting result. PATIENTS AND METHODS: This study was carried out on sixty cases who had done reduction mammoplasty from January 2009 to December 2014...
May 2016: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/27827906/t%C3%AE-riii-expression-in-human-breast-cancer-stroma-and-the-role-of-soluble-t%C3%AE-riii-in-breast-cancer-associated-fibroblasts
#17
Bojana Jovanović, Michael W Pickup, Anna Chytil, Agnieszka E Gorska, Kimberly C Johnson, Harold L Moses, Philip Owens
The TGF-β pathway plays a major role in tumor progression through regulation of epithelial and stromal cell signaling. Dysfunction of the pathway can lead to carcinoma progression and metastasis. To gain insight into the stromal role of the TGF-β pathway in breast cancer, we performed laser capture microdissection (LCM) from breast cancer patients and reduction mammoplasty patients. Microdissected tumor stroma and normal breast stroma were examined for gene expression. Expression of the TGF-β type III receptor (TGFBR3) was greatly decreased in the tumor stroma compared to control healthy breast tissue...
November 4, 2016: Cancers
https://www.readbyqxmd.com/read/27826457/distant-migration-of-multiple-siliconomas-in-lower-extremities-following-breast-implant-rupture-case-report
#18
Joo Hyun Oh, Seung Yong Song, Dae Hyun Lew, Dong Won Lee
Siliconoma from ruptured breast implants has been reported in multiple body sites, including but not limited to the breast parenchyma, axillary lymph nodes, upper arm, and even lower leg. In this regard, we report a rare case of distant silicone migration to the lower extremities after traumatic breast implant rupture. A 55-year-old Asian woman who received bilateral augmentation mammoplasty 20 years ago presented with ruptured breast implants from a car accident 2 years earlier. Magnetic resonance imaging confirmed intracapsular and extracapsular rupture of the right breast implant, showing "linguine sign...
October 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/27807451/lifespan-extension-and-sustained-expression-of-stem-cell-phenotype-of-human-breast-epithelial-stem-cells-in-a-medium-with-antioxidants
#19
Kai-Hung Wang, An-Pei Kao, Chia-Cheng Chang, Ta-Chin Lin, Tsung-Cheng Kuo
We have previously reported the isolation and culture of a human breast epithelial cell type with stem cell characteristics (Type I HBEC) from reduction mammoplasty using the MSU-1 medium. Subsequently, we have developed several different normal human adult stem cell types from different tissues using the K-NAC medium. In this study, we determined whether this low calcium K-NAC medium with antioxidants (N-acetyl-L-cysteine and L-ascorbic acid-2-phosphate) is a better medium to grow human breast epithelial cells...
2016: Stem Cells International
https://www.readbyqxmd.com/read/27789587/expression-of-mir-18a-and-mir-210-in-normal-breast-tissue-as-candidate-biomarkers-of-breast-cancer-risk
#20
Ali Shidfar, Fabricio F Costa, Denise Scholtens, Jared M Bischof, Megan E Sullivan, David Z Ivancic, Elio F Vanin, Marcelo B Soares, Jun Wang, Seema A Khan
miRNAs are noncoding RNAs with abnormal expression in breast cancer; their expression in high-risk benign breast tissue may relate to breast cancer risk. We examined miRNA profiles in contralateral unaffected breasts (CUB) of patients with breast cancer and validated resulting candidates in two additional sample sets. Expression profiles of 754 mature miRNAs were examined using TaqMan Low Density Arrays in 30 breast cancer samples [15 estrogen receptor (ER)-positive and 15 ER-negative] and paired CUBs and 15 reduction mammoplasty controls...
January 2017: Cancer Prevention Research
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