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https://www.readbyqxmd.com/read/27908586/standard-wide-local-excision-or-bilateral-reduction-mammoplasty-in-large-breasted-women-with-small-tumours-surgical-and-patient-reported-outcomes
#1
R Di Micco, R L O'Connell, P A Barry, N Roche, F A MacNeill, J E Rusby
INTRODUCTION: Oncoplastic breast surgery is used to extend the role of breast-conserving surgery (BCS) to women with an unfavourable tumour to breast volume ratio. However, large-breasted women with a relatively small breast cancer may be offered bilateral reduction mammoplasty (BRM) despite being suitable for standard BCS as the more complex surgery may have advantages in terms of patient satisfaction and reduced adverse effects of radiotherapy. PATIENT AND METHODS: This retrospective study evaluated surgical and patient-reported outcome measures (PROMs) in large-breasted women with early (<3 cm) breast cancer, who have undergone unilateral standard BCS or BRM...
November 17, 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27899130/antibiotic-prophylaxis-in-reduction-mammaplasty-study-protocol-for-a-randomized-controlled-trial
#2
Edgard Silva Garcia, Daniela Francescato Veiga, Joel Veiga-Filho, Isaías Vieira Cabral, Natália Lana Larcher Pinto, Neil Ferreira Novo, Miguel Sabino Neto, Lydia Masako Ferreira
BACKGROUND: The role of antibiotics in surgical procedures where the risk of surgical site infection (SSI) is low remains uncertain. There is, to date, no evidence to justify the routine use of antibiotics in postoperative reduction mammaplasty. The aim of this study is to evaluate the effect of postoperative antibiotic treatment on the occurrence of SSI after breast reduction surgery. METHODS: This is a double-blind randomized clinical trial with 124 breast hypertrophy patients allocated to two treatment groups: antibiotic (n = 62) and placebo (n = 62)...
November 30, 2016: Trials
https://www.readbyqxmd.com/read/27861132/chronic-morel-lavall%C3%A3-e-lesion-a-novel-minimally-invasive-method-of-treatment
#3
Ramireddy Mettu, Harsha Vardhan Surath, Hanumantha Rao Chayam, Amaranth Surath
A Morel-Lavallée lesion is a closed internal degloving injury resulting from a shearing force applied to the skin. The etiology of this condition may be motor vehicle accidents, falls, contact sports (ie, football, wrestling),1 and iatrogenic after mammoplasty or abdominal liposuction.2 Common sites of the lesions include the pelvis and/or thigh.3 Isolated Morel-Lavallée lesions without underlying fracture are likely to be missed, which result in chronicity. Management of this condition often requires extensive surgical procedures such as debridement, sclerotherapy, serial percutaneous drainage, negative pressure wound therapy (NPWT), and skin grafting...
November 2016: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/27833284/long-term-follow-up-and-patient-satisfaction-after-reduction-mammoplasty-superomedial-versus-inferior-pedicle
#4
Mohamed Makboul, Mahmoud S Abdelhamid, Ghada S Al-Attar
BACKGROUND: Surgery for hypertrophied breasts represents a challenge for plastic surgeons. The search for a good post-surgical cosmetic breast has led to the development of many techniques. Objectives for reduction mammoplasty are to achieve elevated, symmetrical breasts, a round shape, good projection, small cicatrices that are not very perceptible, and a lasting result. PATIENTS AND METHODS: This study was carried out on sixty cases who had done reduction mammoplasty from January 2009 to December 2014...
May 2016: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/27827906/t%C3%AE-riii-expression-in-human-breast-cancer-stroma-and-the-role-of-soluble-t%C3%AE-riii-in-breast-cancer-associated-fibroblasts
#5
Bojana Jovanović, Michael W Pickup, Anna Chytil, Agnieszka E Gorska, Kimberly C Johnson, Harold L Moses, Philip Owens
The TGF-β pathway plays a major role in tumor progression through regulation of epithelial and stromal cell signaling. Dysfunction of the pathway can lead to carcinoma progression and metastasis. To gain insight into the stromal role of the TGF-β pathway in breast cancer, we performed laser capture microdissection (LCM) from breast cancer patients and reduction mammoplasty patients. Microdissected tumor stroma and normal breast stroma were examined for gene expression. Expression of the TGF-β type III receptor (TGFBR3) was greatly decreased in the tumor stroma compared to control healthy breast tissue...
November 4, 2016: Cancers
https://www.readbyqxmd.com/read/27826457/distant-migration-of-multiple-siliconomas-in-lower-extremities-following-breast-implant-rupture-case-report
#6
Joo Hyun Oh, Seung Yong Song, Dae Hyun Lew, Dong Won Lee
Siliconoma from ruptured breast implants has been reported in multiple body sites, including but not limited to the breast parenchyma, axillary lymph nodes, upper arm, and even lower leg. In this regard, we report a rare case of distant silicone migration to the lower extremities after traumatic breast implant rupture. A 55-year-old Asian woman who received bilateral augmentation mammoplasty 20 years ago presented with ruptured breast implants from a car accident 2 years earlier. Magnetic resonance imaging confirmed intracapsular and extracapsular rupture of the right breast implant, showing "linguine sign...
October 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/27807451/lifespan-extension-and-sustained-expression-of-stem-cell-phenotype-of-human-breast-epithelial-stem-cells-in-a-medium-with-antioxidants
#7
Kai-Hung Wang, An-Pei Kao, Chia-Cheng Chang, Ta-Chin Lin, Tsung-Cheng Kuo
We have previously reported the isolation and culture of a human breast epithelial cell type with stem cell characteristics (Type I HBEC) from reduction mammoplasty using the MSU-1 medium. Subsequently, we have developed several different normal human adult stem cell types from different tissues using the K-NAC medium. In this study, we determined whether this low calcium K-NAC medium with antioxidants (N-acetyl-L-cysteine and L-ascorbic acid-2-phosphate) is a better medium to grow human breast epithelial cells...
2016: Stem Cells International
https://www.readbyqxmd.com/read/27789587/expression-of-mir-18a-and-mir-210-in-normal-breast-tissue-as-candidate-biomarkers-of-breast-cancer-risk
#8
Ali Shidfar, Fabricio F Costa, Denise M Scholtens, Jared M Bischof, Megan E Sullivan, David Ivancic, Elio F Vanin, Marcelo B Soares, Jun Wang, Seema A Khan
miRNAs are non-coding RNAs with abnormal expression in breast cancer (BC); their expression in high-risk benign breast tissue may relate to BC risk. We examined miRNA profiles in contralateral unaffected breasts (CUBs) of BC patients and validated resulting candidates in two additional sample sets. Expression profiles of 754 mature miRNAs were examined using TaqMan Low Density Arrays in 30 BC samples (15 ER-positive and 15 ER-negative) and paired CUBs; and 15 reduction mammoplasty (RM) controls. Pairwise comparisons identified miRNAs with significantly differential expression...
October 27, 2016: Cancer Prevention Research
https://www.readbyqxmd.com/read/27769601/radiographic-evaluation-of-vessel-count-and-density-with-quantitative-magnetic-resonance-imaging-during-external-breast-expansion-in-asian-women-a-prospective-clinical-trial
#9
Yujin Myung, Heeyeon Kwon, Changsik Pak, Hobin Lee, Jae Hoon Jeong, Chan Yeong Heo
BACKGROUND: Breast augmentation with fat transfer does not bear the risks associated with silicone implantation. The method can potentially be especially useful in Asian women, who often reject augmentation mammoplasty with implants. This prospective clinical trial evaluated the effects of external breast expansion on breast density and vessel count using magnetic resonance imaging. METHODS: Thirty-four enrolled patients were instructed to apply one of two devices, the conventional BRAVA device (used in the AESTES trial) or a novel external expansion device (EVERA) designed for Asian women, continuously for 8 h per day for 12 weeks...
September 28, 2016: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/27758851/multimodality-approach-in-the-diagnosis-and-management-of-bilateral-giant-juvenile-breast-fibroadenoma
#10
Noora Rafeek, Rajeswaran Rangasami, Kamakshi Dhanraj, Santhosh Joseph
Juvenile giant fibroadenoma is a very rare breast disease affecting young girls of premenarche and adolescent ages. It is a benign fibroepithelial tumour characterised by stromal and epithelial proliferation that causes rapidly growing breast mass. Bilateral symmetrical involvement is extremely rare. In this article, we describe this entity in a girl aged 13 years who presented with bilateral gigantically enlarged breasts. Ultrasonography and MRI showed large, multilobulated masses involving both breasts entirely...
October 6, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27757340/the-transareolar-periareolar-approach
#11
Jonathan Zelken, Jung-Ju Huang, Chih-Wei Wu, Yi-Ling Lin, Ming-Huei Cheng
The periareolar approach is limited by areolar diameter. Asian women typically have smaller areolae than Western women. Voluminous and form-stable silicone implants demand larger incisions. Zigzag transareolar approaches closely approximate the nipple and improve exposure, but scar appearance remains problematic, and there is a risk of ductal injury and capsular contracture. We prefer a zigzag incision that straddles the areolar border. Between 2013 and 2015, 11 augmentation mammoplasties (20 incisions) were performed through a transareolar-periareolar (TAPA) incision...
September 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/27757327/quality-of-life-and-aesthetic-plastic-surgery-a-systematic-review-and-meta-analysis
#12
Rodrigo Dreher, Carolina Blaya, Juliana L C Tenório, Renato Saltz, Pedro B Ely, Ygor A Ferrão
: Quality of life (QoL) is an important outcome in plastic surgery. However, authors use different scales to address this subject, making it difficult to compare the outcomes. To address this discrepancy, the aim of this study was to perform a systematic review and a random effect meta-analysis. METHODS: The search was made in two electronic databases (LILACS and PUBMED) using Mesh and non-Mesh terms related to aesthetic plastic surgery and QoL. We performed qualitative and quantitative analyses of the gathered data...
September 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/27755066/comparison-of-reconstructive-outcomes-in-breast-cancer-patients-with-preexisting-subpectoral-implants-implant-sparing-mastectomy-with-delayed-implant-exchange-versus-immediate-tissue-expander-reconstruction
#13
Sangeetha Prabhakaran, Megan Melody, Rose Trotta, Amina Lleshi, Weihong Sun, Paul D Smith, Nazanin Khakpour, Deniz Dayicioglu
BACKGROUND: Women who have undergone prior augmentation mammoplasty represent a unique subset of breast cancer patients with several options available for breast reconstruction. We performed a single institution review of surgical outcomes of breast reconstruction performed in patients with breast cancer with prior history of subpectoral breast augmentation. METHODS: Institutional review board-approved retrospective review was conducted among patients with previously mentioned criteria treated at our institution between 2000 and 2014...
June 2016: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/27721868/combined-subpectoral-implantation-of-implantable-cardioverter-defibrillator-and-augmentation-mammoplasty-in-a-young-female-patient
#14
Dong-Jun Kim, Jae-Sun Uhm, Je Wook Park, Jong-Chan Youn, Dong Won Lee, Bon-Nyeo Koo, Moon-Hyoung Lee
Subcutaneous implantation of a cardiac implantable electronic device is the standard method. Occasionally, subpectoral cardiac implantable electronic device (CIED) implantation via axillary incisions is performed in young female patients for cosmetic purposes. Because subpectoral CIED implantation and augmentation mammoplasty involve the same layer, it is feasible to perform both procedures simultaneously. We report a case of combined subpectoral implantation of an implantable cardioverter-defibrillator and augmentation mammoplasty via the axillary approach in a young female patient with dilated cardiomyopathy and small breasts...
September 2016: Korean Circulation Journal
https://www.readbyqxmd.com/read/27699462/barbed-sutures-in-body-contouring-outcome-analysis-of-695-procedures-in-623-patients-and-technical-advances
#15
Dominik Duscher, Michael S Pollhammer, Raphael Wenny, Andreas Shamiyeh, Manfred Schmidt, Georg M Huemer
INTRODUCTION: Surgical wound closure is often complicated by suture-related issues. The recent introduction of knotless barbed sutures may address the shortcomings of conventional sutures and offer the additional benefit of reduced operating time. In this paper, we describe our experience with barbed sutures for body-contouring procedures. We share technical insights and evaluate postoperative complications. PATIENTS AND METHODS: A retrospective assessment of prospectively collected data over a period of more than 5 years was undertaken...
December 2016: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/27692851/bilateral-mammoplasty-for-cancer-surgical-oncological-and-patient-reported-outcomes
#16
R Di Micco, R L O'Connell, P A Barry, N Roche, F A MacNeill, J E Rusby
INTRODUCTION: Bilateral mammoplasty (BM) can optimise oncological safety and aesthetic outcomes in women with large or ptotic breasts whose tumour to breast volume ratio or tumour location pose a challenge to standard breast-conserving therapy (BCT) and for whom mastectomy (with or without reconstruction) may be the only alternative. METHODS: We undertook a comprehensive analysis of surgical outcomes (complications according to the Clavien Dindo classification), acute radiation morbidity (Radiation Therapy Oncology Group classification), oncological outcomes, and patient satisfaction (BREAST-Q questionnaire) in women who underwent BM for breast cancer (BC) from June 2009-November 2014...
September 9, 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27689046/informed-consent-as-a-litigation-strategy-in-the-field-of-aesthetic-surgery-an-analysis-based-on-court-precedents
#17
Bo Young Park, Jungwoo Kwon, So Ra Kang, Seung Eun Hong
BACKGROUND: In an increasing number of lawsuits doctors lose, despite providing preoperative patient education, because of failure to prove informed consent. We analyzed judicial precedents associated with insufficient informed consent to identify judicial factors and trends related to aesthetic surgery medical litigation. METHODS: We collected data from civil trials between 1995 and 2015 that were related to aesthetic surgery and resulted in findings of insufficient informed consent...
September 2016: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/27682158/reduction-mammoplasty-using-oxidized-regenerated-cellulose-as-a-filler-in-breast-conservation-surgery
#18
Gianluca Franceschini, Alejandro Martin Sanchez, Giuseppe Visconti, Alba Di Leone, Sabatino D'Archi, Antonino Mulè, Angela Santoro, Marzia Salgarello, Riccardo Masetti
: Oncoplastic surgery of the breast has generated great excitement over the past years and has become an integrated component of the surgical treatment of breast cancer. Oncoplastic procedures (OPP) associate the best surgical oncologic principles to achieve wide tumor-free margins with the best principles of plastic surgery to optimize cosmetic outcomes. So, a number of conventional mammoplasty techniques have been adapted to allow reconstruction of resection defects with parenchymal flaps using a variety of different approaches...
2016: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/27659691/in-silico-insights-on-the-prognostic-potential-of-immune-cell-infiltration-patterns-in-the-breast-lobular-epithelium
#19
J C L Alfonso, N S Schaadt, R Schönmeyer, N Brieu, G Forestier, C Wemmert, F Feuerhake, H Hatzikirou
Scattered inflammatory cells are commonly observed in mammary gland tissue, most likely in response to normal cell turnover by proliferation and apoptosis, or as part of immunosurveillance. In contrast, lymphocytic lobulitis (LLO) is a recurrent inflammation pattern, characterized by lymphoid cells infiltrating lobular structures, that has been associated with increased familial breast cancer risk and immune responses to clinically manifest cancer. The mechanisms and pathogenic implications related to the inflammatory microenvironment in breast tissue are still poorly understood...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27647991/oncoplastic-reduction-mammoplasty-for-breast-cancer-in-women-with-macromastia-long-term-aesthetic-functional-and-satisfaction-outcomes
#20
Mustafa Emiroglu, Cem Karaali, Semra Salimoglu, Ismail Sert, Cengiz Aydın
AIM OF THE STUDY: Despite the increase in studies concerning oncoplastic reduction mammoplasty (ORM), data showing long-term aesthetic and patient satisfaction for ORM in patients with macromastia remain limited. Therefore, this study evaluated the long-term results of tumorectomy and concomitant bilateral ORM for early-stage breast cancer patients with macromastia in terms of cosmesis, patient satisfaction, and functional outcomes. MATERIAL AND METHODS: Retrospective data of patients with macromastia undergoing ORM for breast cancer between 1996 and 2011 were examined and evaluated regarding the aesthetic results, patient satisfaction, and functional outcomes...
2016: Contemporary Oncology Współczesna Onkologia
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