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https://www.readbyqxmd.com/read/29221279/endoscopic-naso-leakage-drainage-a-safe-and-effective-method-for-the-management-of-intrathoracic-anastomotic-leakage-after-esophagectomy
#1
Yi Zhang, Yong-Xing Zhang, Jian-Wei Hu, Guang-Yu Yao, Liang Xue, Hong Fan, Yi-Qun Zhang, Qun Wang
Background: Intrathoracic anastomotic leakage (IAL) remains a major complication of esophagectomy. Main non-surgical options of management include chest drainage and endoscope interventions. This study is aim to present our experience and assess the efficacy of endoscopic naso-leakage drainage (ENLD) in patients with IAL. Methods: From June 2011 to January 2017, 67 patients who developed IAL after esophagectomy and managed by non-surgical approaches were analyzed retrospectively...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29210772/bleeding-complication-rates-are-higher-in-females-after-continuous-flow-left-ventricular-assist-device-implantation
#2
Zubin Yavar, Jennifer A Cowger, Sina L Moainie, Christopher T Salerno, Ashwin K Ravichandran
The aims of this analysis were to characterize the burden and timing of bleeding events in females versus males on left ventricular assist device (LVAD) support. A single-center retrospective review of 375 patients receiving continuous-flow LVADs was performed. Bleeding events included gastrointestinal, naso-oropharyngeal, gynecologic (GYN), intracranial hemorrhage (ICH), and mediastinal bleeding. Cox hazard ratios (HRs) [95% CI] and incident event rates for females versus males were calculated. Eighty-four females (22%) and 291 males (78%) received an LVAD...
November 27, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29209045/mir-211-is-essential-for-adult-cone-photoreceptor-maintenance-and-visual-function
#3
Sara Barbato, Elena Marrocco, Daniela Intartaglia, Mariateresa Pizzo, Sabrina Asteriti, Federica Naso, Danila Falanga, Rajeshwari S Bhat, Nicola Meola, Annamaria Carissimo, Marianthi Karali, Haydn M Prosser, Lorenzo Cangiano, Enrico Maria Surace, Sandro Banfi, Ivan Conte
MicroRNAs (miRNAs) are key post-transcriptional regulators of gene expression that play an important role in the control of fundamental biological processes in both physiological and pathological conditions. Their function in retinal cells is just beginning to be elucidated, and a few have been found to play a role in photoreceptor maintenance and function. MiR-211 is one of the most abundant miRNAs in the developing and adult eye. However, its role in controlling vertebrate visual system development, maintenance and function so far remain incompletely unexplored...
December 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29205183/feasibility-of-conversion-of-percutaneous-cholecystostomy-to-internal-transmural-endoscopic-ultrasound-guided-gallbladder-drainage
#4
Tanyaporn Chantarojanasiri, Saburo Matsubara, Hiroyuki Isayama, Yousuke Nakai, Naminatsu Takahara, Suguru Mizuno, Hirofumi Kogure, Ryunosuke Hakuta, Yukiko Ito, Minoru Tada, Kazuhiko Koike
BACKGROUND/AIM: Percutaneous cholecystostomy [percutaneous transhepatic gallbladder drainage (PTGBD)] is the treatment of choice in surgically unfit patients with acute cholecystitis. However, PTGBD tube removal after symptoms resolution results in 41-46% recurrence. This study aims to demonstrate the feasibility of the conversion of PTGBD to transmural endoscopic ultrasound-guided gallbladder drainage (EUS-GBD) using plastic stents in patients unfit for cholecystectomy. PATIENTS AND METHODS: Patients who underwent internal transmural EUS-GBD as a conversion from PTGBD were reviewed...
November 2017: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/29201033/cell-based-phenotyping-reveals-qtl-for-membrane-potential-maintenance-associated-with-hypoxia-and-salinity-stress-tolerance-in-barley
#5
Muhammad B Gill, Fanrong Zeng, Lana Shabala, Guoping Zhang, Yun Fan, Sergey Shabala, Meixue Zhou
Waterlogging and salinity are two major abiotic stresses that hamper crop production world-wide resulting in multibillion losses. Plant abiotic stress tolerance is conferred by many interrelated mechanisms. Amongst these, the cell's ability to maintain membrane potential (MP) is considered to be amongst the most crucial traits, a positive relationship between the ability of plants to maintain highly negative MP and its tolerance to both salinity and waterlogging stress. However, no attempts have been made to identify quantitative trait loci (QTL) conferring this trait...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29199125/formulation-and-optimization-of-levofloxacin-loaded-chitosan-nanoparticle-for-ocular-delivery-in-vitro-characterization-ocular-tolerance-and-antibacterial-activity
#6
Ameeduzzafar, Syed Sarim Imam, Syed Nasir Abbas Bukhari, Javed Ahmed, Asgar Ali
In this study, chitosan nanoparticles (CH-NPs) were used to encapsulate antibacterial agent levofloxacin for the treatment of ocular infection. The chitosan nanoparticles were prepared by ionic gelation method using chitosan and sodium tripolyphosphate. The developed formulations were evaluated for various physicochemical parameters and optimized formulation was converted into the sol-gel system to enhance the corneal residence time. The developed formulations showed the particle size in nanometric range with high encapsulation, and loading...
November 30, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29195582/microbial-profile-and-characterization-of-blue-bulb-manual-suction-devices-used-to-promote-airway-clearance-in-newborns-in-intrapartum-and-postpartum-units
#7
Pamela V O'Neal, Ellise D Adams, Linda A Hanson, N Edward Damron, Megan Breland Alexander, Jie Zhang, Joseph G Leahy
BACKGROUND: Newborns are suctioned with a blue bulb manual suction device to remove naso-oropharyngeal secretions and promote airway clearance. This study identifies and discusses the microbial profile and characterization of the bulb used in newborns on intrapartum and postpartum units. METHODS: This was a descriptive study with convenience sampling of a total of 50 bulbs used in cesarean births, vaginal births, and on the postpartum unit. The bulbs were tested for microbial growth, and the percentages of contaminated bulbs were calculated...
December 1, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/29195239/secondary-treatment-of-naso-orbital-ethmoid-injuries
#8
Alan S Herford
No abstract text is available yet for this article.
December 2017: Facial Plastic Surgery: FPS
https://www.readbyqxmd.com/read/29187946/the-endoscopic-endonasal-approach-to-cranio-cervical-junction-the-complete-panel
#9
REVIEW
Nouman Aldahak, Bertram Richter, Joseph Synèse Bemora, Jeffery Thomas Keller, Sebastien Froelich, Khaled Mohamed Abdel Aziz
We aim to establish a complete summary on the Endoscopic Endonasal Approach (EEA) to Cranio Cervical Junction (CCJ): evolution since first description, criteria to predict the feasibility and limitations, anatomical landmarks, indications and biomechanical evaluation after performing the approach. A comprehensive literature search to identify all available literature published between March 2002 and June 2015, the articles were divided into four categories according to their main purpose: 1- surgical technique, 2- anatomical landmarks and limitations, 3- literature reviews to identify main indications, 4- biomechanical studies...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/29182900/laparoscopic-sleeve-gastrectomy-for-morbid-obesity-role-of-intraluminal-and-intraperitoneal-postoperative-drainage
#10
G Currò, G Piscitelli, C Lazzara, I Komaei, A Fortugno, G Pinto, F Guccione, A Cogliandolo, A Dattola, S Latteri, G Navarra
BACKGROUND AND AIMS: Bleeding and staple line leak are the most common postoperative complications of LSG. To prevent and/or to promptly identify such complications, conventional peri-operative protocols imply post-operative gastric decompression (NGT) and staple line drain (IAD). Our aim was to evaluate the role of naso-gastric tube (NGT) and intra-abdominal drain (IAD) in preventing and/or facilitating identification and treatment of post-operative complications after sleeve gastrectomy...
July 2017: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/29151253/a-two-week-fecal-microbiota-transplantation-course-in-pediatric-patients-with-inflammatory-bowel-disease
#11
Katarzyna Karolewska-Bochenek, Pawel Grzesiowski, Aleksandra Banaszkiewicz, Agnieszka Gawronska, Maria Kotowska, Marcin Dziekiewicz, Piotr Albrecht, Andrzej Radzikowski, Izabella Lazowska-Przeorek
Dysbiosis plays a major role in the etiology of inflammatory bowel disease (IBD). Fecal microbiota transplantation (FMT) is a new promising option for IBD treatment. We aimed to assess the effectiveness of a two-week FMT course in children with IBD. Ten patients, 10-17 years of age with moderate to severe IBD received a course of eight doses of freshly prepared FMT via a naso-duodenal tube or gastroscopy. All of the patients had pancolitis. There were eight cases of ulcerative colitis (UC) and two of Crohn's disease (CD)...
November 19, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29131070/pathophysiology-of-post-transplant-hypertension-in-kidney-transplant-focus-on-calcineurin-inhibitors-induced-oxidative-stress-and-renal-sodium-retention-and-implications-with-rhoa-rho-kinase-pathway
#12
Lorenzo A Calò, Verdiana Ravarotto, Francesca Simioni, Elena Naso, Francesco Marchini, Luciana Bonfante, Lucrezia Furian, Paolo Rigotti
Post-transplant hypertension is a common occurrence during treatment with calcineurin inhibitors (CNIs) in kidney transplant population. The pathogenesis of vasoconstriction induced by CNIs involves vascular tone alterations and kidney sodium transport regulation. Among the factors involved a key role is played by the activation of intrarenal renin-angiotensin system with enhanced release of Angiotensin II (Ang II) and increase of oxidative stress. A common pathway between oxidative stress and hypertension induced by CNIs may be identified in the involvement of the activation of RhoA/Rho kinase pathway, key for the induction of hypertension and cardiovascular-renal remodeling, of the oxidative stress mediated increased nitric oxide (NO) metabolism and increased renal sodium retention via increased activity of thiazide-sensitive sodium chloride cotransporter (NCC) in the distal tubule...
October 16, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29121272/chronic-cigarette-smoking-associates-directly-and-indirectly-with-self-reported-olfactory-alterations-analysis-of-the-2011-2014-national-health-and-nutrition-examination-survey-nhanes
#13
Sarah-Grace Glennon, Tania Huedo-Medina, Shristi Rawal, Howard J Hoffman, Mark D Litt, Valerie B Duffy
Introduction: Population-based studies show inconsistent effects of cigarette smoking on olfactory function. We aimed to identify direct and indirect associations between measures of smoking exposure/nicotine dependence and altered olfaction in a nationally-representative sample of adults. Methods: NHANES 2011-2014 (n=7,418) participants (mean age=57.8±12.2 years) self-reported olfaction and related health and demographic risks. Affirmative answers to three questions defined altered olfaction (olfactory problems in past year; worse ability since age 25; phantom smells)...
November 7, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/29120096/the-association-between-oral-health-status-and-respiratory-pathogen-colonization-with-pneumonia-risk-in-institutionalized-adults
#14
Chl Hong, M M Aung, K Kanagasabai, C A Lim, S Liang, K S Tan
OBJECTIVES: This study aimed to assess the oral health and the prevalence of pre-existing oral colonization with respiratory pathogens in dependent elderly, and whether these factors influence pneumonia development. MATERIALS AND METHODS: Participants residing in a long-term care facility received bedside oral examinations, and information on their oral health (caries status, calculus index and debris index) was obtained. Samples from the tongue and teeth were collected at baseline and at time of pneumonia development...
November 9, 2017: International Journal of Dental Hygiene
https://www.readbyqxmd.com/read/29099943/genetic-labeling-of-car4-expressing-cells-reveals-subpopulations-of-type-iii-taste-cells
#15
Kristina Lossow, Irm Hermans-Borgmeyer, Maik Behrens, Wolfgang Meyerhof
Carbonic anhydrases form an enzyme family of 16 members, which reversibly catalyze the hydration of carbon dioxide to bicarbonate and protons. In lung, kidney, and brain, presence of carbonic anhydrases is associated with protons and bicarbonate transport in capillary endothelium of lung, reabsorption of bicarbonate in proximal renal tubules, and extracellular buffering. In contrast, their role in taste is less clear. Recently, carbonic anhydrase IV expression was detected in sour-sensing presynaptic taste cells and was associated with the taste of carbonation, yet the precise role and cell population remained uncertain...
October 31, 2017: Chemical Senses
https://www.readbyqxmd.com/read/29077981/tissue-specific-differences-in-immune-cell-subsets-located-in-the-naso-oropharyngeal-associated-lymphoid-tissues
#16
Maria Bankvall, Mats Jontell, Agnes Wold, Sofia Östman
Defining the immune cells within the naso-oropharyngeal-associated lymphoid tissues would promote the development of efficient oral and nasal delivered immunotherapies. The aim was to compare murine antigen-presenting cells (APCs) and T-cell subsets in the nose-associated lymphoid tissues (NALT), cervical lymph nodes (CLN), mesenteric lymph nodes (MLN) and peripheral lymph nodes (PLN) using flow cytometry and in vitro proliferation assays. Overall, the NALT contained a higher proportion of APCs and a lower proportion of T cells compared to the CLN, MLN, and PLN...
October 27, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/29063871/a-multi-institutional-consensus-on-how-to-perform-endoscopic-ultrasound-guided-peri-pancreatic-fluid-collection-drainage-and-endoscopic-necrosectomy
#17
Jintao Guo, Adrian Saftoiu, Peter Vilmann, Pietro Fusaroli, Marc Giovannini, Girish Mishra, Surinder S Rana, Sammy Ho, Jan-Werner Poley, Tiing Leong Ang, Evangelos Kalaitzakis, Ali A Siddiqui, Jose G De La Mora-Levy, Sundeep Lakhtakia, Manoop S Bhutani, Malay Sharma, Shuntaro Mukai, Pramod Kumar Garg, Linda S Lee, Juan J Vila, Everson Artifon, Douglas G Adler, Siyu Sun
There is a lack of consensus on how endoscopic ultrasound (EUS)-guided pseudocyst drainage and endoscopic necrosectomy should be performed. This survey was carried out amongst members of the EUS Journal Editorial Board to describe their practices in performing this procedure. This was a worldwide multi-institutional survey amongst members of the EUS Journal Editorial Board in May 2017. The responses to a 22-question survey with respect to the practice of EUS-guided pseudocyst drainage and endoscopic necrosectomy were obtained...
September 2017: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/29057501/different-approaches-to-heart-valve-decellularization-a-comprehensive-overview-of-the-past-30%C3%A2-years
#18
REVIEW
Filippo Naso, Alessandro Gandaglia
Xenogeneic decellularized heart valve scaffolds have the potential to overcome the limitations of existing bioprosthetic heart valves that have limited duration due to calcification and tissue degeneration phenomena. This article presents a review of 30 years of decellularization approaches adopted in cardiovascular tissue engineering, with a focus on the use, either individually or in combination, of different detergents. The safety and efficacy of cell-removal procedures are specifically reported and discussed, as well as the structure and biomechanics of the treated extracellular matrix (ECM)...
October 22, 2017: Xenotransplantation
https://www.readbyqxmd.com/read/29053434/alpha-gal-inactivated-heart-valve-bioprostheses-exhibit-an-anti-calcification-propensity-similar-to-knockout-tissues
#19
Filippo Naso, Ugo Stefanelli, Edward Buratto, Giovanna Lazzari, Andrea Perota, Cesare Galli, Alessandro Gandaglia
BACKGROUND: Glutaraldehyde (GLA) has been used to crosslink bioprosthetic heart valve (BHVs) tissues to enhance their stability, besides ensuring a satisfactory degree of immunological tolerance. Unfortunately, GLA fixation does not guarantee a complete tissue biocompatibility of BHVs in currently used devices. The interaction between preformed human anti-alpha-Gal antibody and alpha-Gal antigens promotes the calcification of GLA-treated alpha-Gal-positive tissue. Recently, an alarming correlation between the presence of the alpha-Gal epitope and a premature BHVs degeneracy was reported...
October 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29036029/-anterior-skull-base-and-pericranial-flap-ossification-after-frontofacial-monobloc-advancement
#20
Anne Morice, Giovanna Paternoster, Agnès Ostertag, Syril James, Martine Cohen-Solal, Roman H Khonsari, Eric Arnaud
BACKGROUND: Frontofacial monobloc advancement (FFMBA) creates a communication between the anterior cranial fossa and nasal cavities. To tackle this issue, trans-orbital pericranial pedicled flaps (PF) are routinely performed in our center. This study aimed to assess the post-operative ossification of the anterior skull base and PF following FFMBA, and to identify factors influencing this ossification. METHODS: Measurements of the skull base only (SB) and of the ossified PF together with the SB (SB-OPF) were performed on CT scans at the naso-frontal (NF) and the naso-ethmoïdo-frontal (NEF) junctions...
October 12, 2017: Plastic and Reconstructive Surgery
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