keyword
https://read.qxmd.com/read/38533234/titanium-mesh-cranioplasty-for-cosmetically-disfiguring-cranio-facial-tumours-in-a-resource-limited-setting
#1
JOURNAL ARTICLE
C O Anele, S A Balogun, C O Ezeaku, T O Ajekwu, H E Omon, G O Ejembi, E O Komolafe
BACKGROUND: The aesthetic reconstruction of disfiguring cranio-facial defects after tumour excision can be quite challenging to the neurosurgeon with limited resources. The choice of cranioplasty implant, intraoperative technicalities and the patients' postoperative appearance are critical considerations in management. There are a number of synthetic materials available for cranioplasty, however, the customised implants are not readily available in our practice setup. They are also mostly constructed and contoured after the bony defect has been created or require sophisticated software construction pre-operatively...
July 2024: World neurosurgery: X
https://read.qxmd.com/read/38514650/mir-218-5p-and-doxorubicin-combination-enhances-anticancer-activity-in-breast-cancer-cells-through-parkin-dependent-mitophagy-inhibition
#2
JOURNAL ARTICLE
Francesco Davide Naso, Krenare Bruqi, Valeria Manzini, Valerio Chiurchiù, Mara D'Onofrio, Ivan Arisi, Flavie Strappazzon
Breast Cancer (BC) is one of the most common tumours, and is known for its ability to develop resistance to chemotherapeutic treatments. Autophagy has been linked to chemotherapeutic response in several types of cancer, highlighting its contribution to this process. However, the role of mitophagy, a selective form of autophagy responsible for damaged mitochondria degradation, in the response to therapies in BC is still unclear. In order to address this point, we analysed the role of mitophagy in the treatment of the most common anticancer drug, doxorubicin (DXR), in different models of BC, such as a luminal A subtype-BC cell line MCF7 cells, cultured in 2-Dimension (2D) or in 3-Dimension (3D), and the triple negative BC (TNBC) cell line MDA-MB-231...
March 21, 2024: Cell Death Discovery
https://read.qxmd.com/read/38512103/il-17-gal-10-and-tgf-%C3%AE-are-promising-noninvasive-biomarkers-of-pediatric-eosinophilic-esophagitis
#3
JOURNAL ARTICLE
Martina Votto, Matteo Naso, Mara De Amici, Riccardo Castagnoli, Annalisa De Silvestri, Maria De Filippo, Giorgia Testa, Gian Luigi Marseglia, Amelia Licari
No abstract text is available yet for this article.
March 2024: Pediatric Allergy and Immunology
https://read.qxmd.com/read/38482477/successful-management-of-bile-duct-injury-with-duodenal-perforation-using-endoscopic-naso-pancreatic-drainage-and-fully-covered-self-expandable-metallic-stent-deployment
#4
JOURNAL ARTICLE
Haruka Okada, Eisuke Iwasaki, Seiichiro Fukuhara, Masayasu Horibe, Motoki Sasaki, Takanori Kanai, Naohisa Yahagi, Motohiko Kato
Video 1A case of bile and pancreatic duct injury with duodenal perforation during endoscopic submucosal dissection for superficial duodenal epithelial neoplasia.
March 2024: VideoGIE
https://read.qxmd.com/read/38480114/morphological-phylogeny-and-revision-of-sycophila-and-ficomila-hymenoptera-chalcidoidea-eurytomidae-associated-with-afrotropical-fig-trees-moraceae-ficus
#5
JOURNAL ARTICLE
Hossein Lotfalizadeh, Grard Delvare, Astrid Cruaud, Jean-Yves Rasplus
Eurytomidae (Chalcidoidea) species associated with fig trees (Ficus) are still poorly documented. A phylogenetic analysis of 63 morphological characters was conducted to revise Afrotropical species of Sycophila Walker and Ficomila Bouek associated with fig trees. Based on our results, which also included Palaearctic species of Sycophila, three subgenera of Sycophila are proposed: Sycophila s. str., Tineomyza Rondani stat. rev. and a new subgenus, Ficorytoma subgen. n. Lotfalizadeh & Rasplus. Ficomila is maintained as a valid genus...
January 17, 2024: Zootaxa
https://read.qxmd.com/read/38465042/advanced-and-metastatic-gastrointestinal-stromal-tumors-presenting-with-surgical-emergencies-managed-with-surgical-resection-a-case-series
#6
Divij Jayant, Mrinal Goyal, Vipul Thakur, Swapnesh Sahu, Basil Babu, Satish Subbiah Nagaraj, Cherring Tandup, Arunanshu Behera
Advanced and metastatic gastrointestinal stromal tumors (GISTs) presenting with surgical emergencies are rare. Neoadjuvant imatinib being the treatment of choice for non-metastatic advanced disease with a proven role in downstaging the disease may not be feasible in patients presenting with bleeding and obstruction. We present a case series with retrospective analysis of a prospectively maintained database of patients with advanced and metastatic GISTs presenting with surgical emergencies. Clinical characteristics, imaging and endoscopic findings, surgical procedures, histological findings, and outcomes in these patients were studied...
February 2024: Curēus
https://read.qxmd.com/read/38460232/exploring-the-potential-anti-thyroid-activity-of-acetyl-l-carnitine-lactoperoxidase-inhibition-profile-iodine-complexation-and-scavenging-power-against-h-2-o-2-experimental-and-theoretical-studies
#7
JOURNAL ARTICLE
Janetsi Y Caro-Ramírez, Carlos A Franca, Martín Lavecchia, Luciana G Naso, Patricia A M Williams, Evelina G Ferrer
L-Acetylcarnitine (ALC), a versatile compound, has demonstrated beneficial effects in depression, Alzheimer's disease, cognitive impairment, and other conditions. This study focuses on its antithyroid activity. The precursor molecule, L-carnitine, inhibited the uptake of triiodothyronine (T3) and thyroxine (T4), and it is possible that ALC may reduce the iodination process of T3 and T4. Currently, antithyroid drugs are used to control the excessive production of thyroid hormones (TH) through various mechanisms: (i) forming electron donor-acceptor complexes with molecular iodine, (ii) eliminating hydrogen peroxide, and (iii) inhibiting the enzyme thyroid peroxidase...
February 29, 2024: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://read.qxmd.com/read/38452823/specific-molecular-peak-analysis-by-ion-mobility-spectrometry-of-volatile-organic-compounds-in-urine-of-covid-19-patients-a-novel-diagnostic-approach
#8
JOURNAL ARTICLE
T Boeselt, P Terhorst, J Kroenig, C Nell, M Spielmanns, U Boas, M Veith, C Vogelmeier, T Greulich, A R Koczulla, B Beutel, J Huber, H Heers
INTRODUCTION: SARS-CoV-2 is usually diagnosed from naso-/oropharyngeal swabs which are uncomfortable and prone to false results. This study investigated a novel diagnostic approach to Covid-19 measuring volatile organic compounds (VOC) from patients' urine. METHODS: Between June 2020 and February 2021, 84 patients with positive RT-PCR for SARS-CoV-2 were recruited as well as 54 symptomatic individuals with negative RT-PCR. Midstream urine samples were obtained for VOC analysis using ion mobility spectrometry (IMS) which detects individual molecular components of a gas sample based on their size, configuration, and charge after ionization...
March 5, 2024: Journal of Virological Methods
https://read.qxmd.com/read/38447882/aurka-tpx2-co-overexpression-in-nontransformed-cells-promotes-genome-instability-through-induction-of-chromosome-mis-segregation-and-attenuation-of-the-p53-signalling-pathway
#9
JOURNAL ARTICLE
Francesco Davide Naso, Federica Polverino, Danilo Cilluffo, Linda Latini, Venturina Stagni, Italia Anna Asteriti, Alessandro Rosa, Silvia Soddu, Giulia Guarguaglini
The Aurora-A kinase (AurkA) and its major regulator TPX2 (Targeting Protein for Xklp2) are key mitotic players frequently co-overexpressed in human cancers, and the link between deregulation of the AurkA/TPX2 complex and tumourigenesis is actively investigated. Chromosomal instability, one of the hallmarks of cancer related to the development of intra-tumour heterogeneity, metastasis and chemo-resistance, has been frequently associated with TPX2-overexpressing tumours. In this study we aimed to investigate the actual contribution to chromosomal instability of deregulating the AurkA/TPX2 complex, by overexpressing it in nontransformed hTERT RPE-1 cells...
March 4, 2024: Biochimica et Biophysica Acta. Molecular Basis of Disease
https://read.qxmd.com/read/38442781/pulmonary-gangliocytic-paraganglioma-an-under-recognized-mimic-of-carcinoid-tumor
#10
JOURNAL ARTICLE
Julia R Naso, Diping Wang, Arthur O Romero, Timothy Leclair, Peter Smit, Jennifer M Boland, Andrew L Folpe, Melanie C Bois
Gangliocytic paragangliomas are rare neoplasms occurring almost exclusively in the ampullary region of the gastrointestinal tract. Although these tumors are not typically considered in the differential diagnosis of primary pulmonary neoplasia, 5 cases of primary pulmonary gangliocytic paragangliomas have been previously reported. Herein we report our experience with 3 additional examples, all referred to our Anatomic Pathology Consultation service. The patients (a 32-year-old man, a 69-year-old woman and a 55-year-old man) each presented with an endobronchial (2 cases) or upper lobe lung mass, ranging from 1...
March 3, 2024: Human Pathology
https://read.qxmd.com/read/38436142/identifying-covid-19-subtypes-by%C3%A2-single-sample-gene-set-enrichemnt-analysis-and-providing-guidance-for-sensitive-drug-selection
#11
JOURNAL ARTICLE
Nan Xiong, Qiangming Sun
This study aimed at using single-sample gene set enrichment analysis scores to cluster naso/pharyngeal swab specimen samples from coronavirus disease 2019 (COVID-19) patients into two clusters. One cluster with higher fractions of immune cells and more active inflammatory-related pathways was called the Immunity-High (Immunity-H) group, and the other one was called the Immunity-Low group. We explored impacts of the method on COVID-19 treatment. First, given that the Immunity-H group was mainly enriched in inflammatory-related pathways and had higher fractions of inflammatory cells, the Immunity-H group may obtain more curative effects from anti-inflammatory treatment...
March 2024: Journal of Medical Virology
https://read.qxmd.com/read/38420581/intraintestinal-fermentation-of-fructo-and-galacto-oligosaccharides-and-the-fate-of-short-chain-fatty-acids-in-humans
#12
JOURNAL ARTICLE
Mara P H van Trijp, Melany Rios-Morales, Ben Witteman, Fentaw Abegaz, Albert Gerding, Ran An, Martijn Koehorst, Bernard Evers, Katja C V van Dongen, Erwin G Zoetendal, Henk Schols, Lydia A Afman, Dirk-Jan Reijngoud, Barbara M Bakker, Guido J Hooiveld
Consumption of fructo- (FOS) and galacto-oligosaccharides (GOS) has health benefits which have been linked in part to short-chain fatty acids (SCFA) production by the gut microbiota. However, detailed knowledge of this process in the human intestine is lacking. We aimed to determine the acute fermentation kinetics of a FOS:GOS mixture in healthy males using a naso-intestinal catheter for sampling directly in the ileum or colon. We studied the fate of SCFA as substrates for glucose and lipid metabolism by the host after infusion of 13 C-SCFA...
March 15, 2024: IScience
https://read.qxmd.com/read/38420555/comprehensive-sampling-of-the-lung-microbiome-in-early-stage-non-small-cell-lung-cancer
#13
JOURNAL ARTICLE
Rishindra M Reddy, Kiran Lagisetty, Jules Lin, Andrew C Chang, Abhinav Achreja, Nithya Ramnath, Deepak Nagrath, Robert Dickson, Frank Weinberg
OBJECTIVES: Data are scarce on whether the composition of the lung microbiome (extending from the nasopharynx to the peripheral lung tissue) varies according to histology or grade of non-small cell lung cancer. We hypothesized that the composition of the lung microbiome would vary according to the histology and the grade of non-small cell lung cancer. METHODS: We collected naso-oral and central lobar (cancer affected, ipsilateral unaffected, and contralateral unaffected) bronchoalveolar lavage fluid and brushing samples from patients with clinical early-stage lung cancer between July 2018 and February 2020 at a single academic center...
February 2024: JTCVS open
https://read.qxmd.com/read/38403613/-anisotropy-and-viscoelasticity-of-different-corneal-regions-in-rabbit-corneal-ectasia-model
#14
JOURNAL ARTICLE
Junchao Wei, Peng Chen, Pengfei Han, Xiaona Liu, Jie Hou, Ce Wu, Jie Song, Weiyi Chen, Xiaona Li
The mechanical properties of the cornea in corneal ectasia disease undergo a significant reduction, yet the alterations in mechanical properties within distinct corneal regions remain unclear. In this study, we established a rabbit corneal ectasia model by employing collagenase II to degrade the corneal matrix within a central diameter of 6 mm. Optical coherence tomography was employed for the in vivo assessment of corneal morphology (corneal thickness and corneal curvature) one month after operation. Anisotropy and viscoelastic characteristics of corneal tissue were evaluated through biaxial and uniaxial testing, respectively...
February 25, 2024: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://read.qxmd.com/read/38367409/nasal-monobloc-osteotomy-for-correction-of-late-nasal-and-orbital-asymmetry-of-unicoronal-synostosis-a-morphometric-and-outcomes-study
#15
JOURNAL ARTICLE
Jessica A Ching, Emmanuelle M Koehl, Christine B Novak, Helen M Branson, Christopher R Forrest
BACKGROUND: Craniofacial asymmetry associated with unicoronal synostosis (UCS) may persist into the teenage years despite surgery in infancy. This study evaluated outcomes following a nasal monobloc procedure by mobilizing a united nasomaxillary and bilateral medial orbital segment of bone (nasal monobloc) to perform corrective translational and rotational movement for secondary correction of residual nasal-orbital asymmetry associated with UCS. METHODS: A retrospective review of all UCS patients treated with nasal monobloc at our institution was performed...
February 1, 2024: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://read.qxmd.com/read/38329527/therapeutic-approaches-to-sinonasal-nut-carcinoma-a-systematic-review
#16
REVIEW
Anastasia Urbanelli, Letizia Nitro, Carlotta Pipolo, Alberto Maccari, Andrea Albera, Gian Luca Fadda, Giovanni Felisati, Roberto Albera, Giancarlo Pecorari, Emanuela Fuccillo, Alberto Maria Saibene
PURPOSE: Sinonasal nuclear protein in testis carcinoma (SNUTC) is a rare, aggressive malignancy caused by genetic rearrangements in the NUTM1 gene. The prognosis of SNUTC ranks among the most unfavorable within the naso-sinusal district, with an overall survival of 9.7 months. This systematic review aimed to determine the best therapeutic strategy for SNUTC. METHODS: We reviewed eligible articles for patient demographics, TNM and stage at presentation, best response after primary treatment, disease-free survival and overall survival (OS) times, other following therapy lines, and final outcomes...
February 8, 2024: European Archives of Oto-rhino-laryngology
https://read.qxmd.com/read/38322940/silica-coated-magnetic-particles-for-efficient-rna-extraction-for-sars-cov-2-detection
#17
JOURNAL ARTICLE
Natalia Capriotti, Leslie C Amorós Morales, Elisa de Sousa, Luciana Juncal, Matias Luis Pidre, Lucila Traverso, Maria Florencia López, Maria Leticia Ferelli, Gabriel Lavorato, Cristian Lillo, Odin Vazquez Robaina, Nicolas Mele, Carolina Vericat, Patricia Schilardi, Alejandra Fabiana Cabrera, Silvana Stewart, Mariano H Fonticelli, Pedro Mendoza Zéliz, Sheila Ons, Victor Romanowski, Claudia Rodríguez Torres
Molecular diagnostic methods to detect and quantify viral RNA in clinical samples rely on the purification of the genetic material prior to reverse transcription polymerase chain reaction (qRT-PCR). Due to the large number of samples processed in clinical laboratories, automation has become a necessity in order to increase method processivity and maximize throughput per unit of time. An attractive option for isolating viral RNA is based on the magnetic solid phase separation procedure (MSPS) using magnetic microparticles...
February 15, 2024: Heliyon
https://read.qxmd.com/read/38311065/true-ileal-amino-acid-digestibility-and-protein-quality-of-15-n-labeled-faba-bean-in-healthy-humans
#18
JOURNAL ARTICLE
Suvi T Itkonen, Juliane Calvez, Gheorghe Airinei, Martin Chapelais, Nadezda Khodorova, Moulay Sahaka, Robert Benamouzig, Frederick L Stoddard, Asko Simojoki, Anne-Maria Pajari, Claire Gaudichon
BACKGROUND: The recommended transition towards more plant-based diets, particularly containing legumes, requires a wider knowledge of plant protein bioavailability. Faba beans are cultivated at different latitudes and are used increasingly in human nutrition. OBJECTIVE: We aimed to assess the nutritional quality of faba bean protein in healthy volunteers equipped with an intestinal tube to implement the ileal 15 N balance method. METHODS: Nine volunteers completed the study (7 men, 2 women, aged 33±10 years, BMI 24...
February 2, 2024: Journal of Nutrition
https://read.qxmd.com/read/38294281/trends-in-management-and-cost-burden-of-facial-fractures-a-14-year-analysis
#19
JOURNAL ARTICLE
Rachel E Weitzman, Tejas Subramanian, Karena Zhao, Andre Shomorony, Anthony P Sclafani
OBJECTIVE: To discuss patient demographics and management and better understand the economic impact associated with the treatment of facial fractures at a major metropolitan level 1 trauma center. STUDY DESIGN: Retrospective chart review. METHODS: We identified 5088 facial fractures in 2479 patients who presented from 2008 to 2022. Patient demographics, mechanism of injury, associated injuries, treatment information, and hospital charges were collected and analyzed to determine factors associated with surgical management and increased cost burden...
January 31, 2024: Laryngoscope
https://read.qxmd.com/read/38289241/assessment-of-the-perception-of-nasal-breathing-using-visual-analog-scale-in-children-with-newly-diagnosed-allergic-rhinitis-the-link-with-asthma
#20
JOURNAL ARTICLE
Maria A Tosca, Irene Schiavetti, Vincenzo Meleca, Matteo Naso, Chiara Trincianti, Giorgio Ciprandi
No abstract text is available yet for this article.
January 30, 2024: Minerva pediatrics
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