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Igor Niechajev
BACKGROUND: The Middle East (ME) proper, a vast area between the East coast of the Mediterranean Sea and Afghanistan, is populated by many nations and tribes. Several nose phenotypes are prevalent throughout the region, but there is no published study encompassing and exploring nose phenotypes encountered in the various countries and subregions of the ME. METHODS: The current study was based on the analysis of compiled data from 1207 patients of ME origin (53% of my total rhinoplasty patient cohort) operated by the author during the years 1985 to 2015...
October 2016: Journal of Craniofacial Surgery
Emmy Verheij, Henricus G X M Thomeer, Frank A Pameijer, Vedat Topsakal
Van Maldergem syndrome (VMS) is a very rare syndrome that was first described in 1992. The main features of this syndrome comprise intellectual disability, blepharo-naso-facial malformation, and hand anomalies. Almost all nine described patients have been shown to be affected by conductive hearing impairment attributed to microtia, and atresia of the outer ear canal. Here, we present a VMS patient with congenital malformations of the middle ear as the main reason for severe conductive bilateral hearing impairment...
October 14, 2016: American Journal of Medical Genetics. Part A
Mariangela Rondanelli, Antonella Riva, Paolo Morazzoni, Pietro Allegrini, Milena Anna Faliva, Maurizio Naso, Alessandra Miccono, Gabriella Peroni, Irene Degli Agosti, Simone Perna
The study aimed to evaluate the effect of Zingiber officinale and Echinacea angustifolia extract supplementation (25 mg of ginger and 5 mg of Echinacea) for 30 days on inflammation and chronic pain in knee osteoarthritis (OA). Consecutive nonsteroidal anti-inflammatory-drugs (NSAIDs) poor responders with chronic inflammation and pain due to knee arthrosis were assessed (15 subjects, age: 67.2 ± 7.9, body mass index: 30.6 ± 7.1, men/women:2/13). The primary endpoint was to determine pain improvement from baseline to Day 30 by Tegner Lysholm Knee Scoring...
October 13, 2016: Natural Product Research
Luciana G Naso, Iker Badiola, Joana Marquez Clavijo, María Valcarcel, Clarisa Salado, Evelina G Ferrer, Patricia A M Williams
The anticancer and antimetastatic behavior of the flavonoid luteolin and its oxidovanadium(IV) complex [VO(lut)(H2O)2]Na·3H2O (VOlut) has been investigated. Considering that the complex displayed strong anticancer activity on MDAMB231 human breast cancer cell line we herein determined through in vitro assays that the complex would probably reduce breast cancer cell metastasis in a higher extent than the natural antioxidant. In the CT26 colon cancer cell line a stronger anticancer effect has also been determined for the complex (IC50 0...
September 24, 2016: Bioorganic & Medicinal Chemistry
Muhammad Rizwan, Gary S Peh, Khadijah Adnan, Sacha L Naso, Alon R Mendez, Jodhbir S Mehta, Evelyn K F Yim
A common indication for corneal transplantation, which is the most transplanted tissue, is a dysfunctional corneal endothelium due to Fuchs' endothelial dystrophy (FED). FED is diagnosed by the presence of in vivo pathological microtopography on the Descemet membrane, which is called corneal guttata. Minimally invasive corneal endothelial cell regenerative procedures such as endothelial cell injection therapy and Rho kinase inhibitor pharmacotherapy have been proposed as alternatives to conventional corneal transplantation for FED patients...
October 4, 2016: Advanced Healthcare Materials
Paul Doughty, Ryan J Ellis, Paul M Oliver
We provide a taxonomic revision of the genus Crenadactylus, a group of very small clawless geckos from western and central Australia, with currently only one recognized species and four subspecies. Morphological comparisons were made on genotyped specimens from two recent genetic studies, then with an expanded sample to encompass all specimens to determine diagnostic characters in addition to morphological and geographic boundaries. Based on our findings, we           elevate the subspecies Crenadactylus ocellatus ocellatus from south-western Australia and C...
September 15, 2016: Zootaxa
Sergei B Yakushin, Giorgio P Martinelli, Theodore Raphan, Bernard Cohen
The vestibulo-sympathetic reflex (VSR) increases blood pressure (BP) upon arising to maintain blood flow to the brain. The optimal directions of VSR activation and whether there are changes in heart rate (HR) are still not clear. This was studied with manually-driven translations, which had pulses and oscillatory linear accelerations of 0.2-2.5 g along the naso-occipital, interaural, and dorso-ventral axes in Isoflurane-anesthetized male, Long-Evans rats. BP and HR were recorded with intra-aortic sensors and accelerationd with 3-D linear accelerometer...
September 28, 2016: Journal of Neurophysiology
Valentina Sini, Alessandra Cassano, Domenico Corsi, Michele De Laurentiis, Teresa Gamucci, Mariella Mauri, Giuseppe Naso, Mario Roselli, Enzo Maria Ruggeri, Giuseppe Tonini, Patrizia Vici, Germano Zampa, Paolo Marchetti
PURPOSE: Bevacizumab, a humanized, anti-vascular endothelial growth factor-A monoclonal antibody, has shown efficacy in a number of cancers. However, its use in metastatic breast cancer (MBC) remains controversial. METHODS: A literature review using the PubMed database was performed to update the currently available clinical trials evidence on bevacizumab in the first-line treatment of breast cancer. In addition, the proceedings of selected oncology annual meetings were searched for relevant presentations...
October 13, 2016: Tumori
Hafiz Muhammad Sharjeel Arshad, Aleida Rodriguez, Faten Suhail
Background. The Syndrome of Inappropriate Antidiuretic Hormone (SIADH) is considered to be the most common cause of euvolemic hyponatremia. The most common malignancy associated with SIADH is small cell lung cancer. We present a rare case of a patient with SIADH secondary to well differentiated squamous cell carcinoma of the naso-oropharynx. Case. A 46-year-old Caucasian woman presented to emergency department with four-week history of progressive dysphagia. On examination, she was found to have a pharyngeal mass...
2016: Case Reports in Nephrology
Elise Weber, Christophe Meyer, Alain Czorny, Brice Chatelain, Mourad Benassarou
INTRODUCTION: Craniosynostoses affecting the forehead sutures can not only cause brain damage, but can also have an esthetic impact, because of the associated orbito-naso-frontal deformations. Reshaping the orbito-naso-frontal bandeau (ONFB) is difficult to appreciate perioperatively and should ideally be customized to each child. The aim of this study was to develop a template to guide the surgeon preoperatively towards an ideal customized remodelling of the ONFB. MATERIALS AND METHODS: A previous study conducted on computed tomography scans obtained from healthy children allowed us to conclude that the whole ONFB shape could be accurately described just by the distance measured between the fronto-zygomatic sutures (FZD), independently of age and gender...
August 21, 2016: Journal of Cranio-maxillo-facial Surgery
Yohei Ueda, Akihiro Yasoda, Yui Yamashita, Yugo Kanai, Keisho Hirota, Ichiro Yamauchi, Eri Kondo, Yoriko Sakane, Shigeki Yamanaka, Kazumasa Nakao, Toshihito Fujii, Nobuya Inagaki
Glucocorticoids are widely used for treating autoimmune conditions or inflammatory disorders. Long-term use of glucocorticoids causes impaired skeletal growth, a serious side effect when they are used in children. We have previously demonstrated that C-type natriuretic peptide (CNP) is a potent stimulator of endochondral bone growth. In this study, we investigated the effect of CNP on impaired bone growth caused by glucocorticoids by using a transgenic mouse model with an increased circulating CNP level. Daily administration of a high dose of dexamethasone (DEX) to 4-week-old male wild-type mice for 4weeks significantly shortened their naso-anal length, which was restored completely in DEX-treated CNP transgenic mice...
November 2016: Bone
Carmelo Luigiano, Giuseppe Iabichino, Benedetto Mangiavillano, Leonardo H Eusebi, Monica Arena, Pierluigi Consolo, Carmela Morace, Sharmila Fagoonee, Matteo Barabino, Enrico Opocher, Rinaldo Pellicano
Bile duct injuries are the most serious complications after hepatobiliary surgery and are associated with high morbidity and mortality. The incidence of iatrogenic injuries of bile ducts has increased after the advent of laparoscopic cholecystectomy. Bile duct injuries present with biliary leak or biliary obstruction or a combination of both. Successful treatment of these complications requires a multidisciplinary team that includes biliary endoscopists, interventional radiologists and hepatobiliary surgeons...
September 2, 2016: Minerva Chirurgica
Erica Kristen Ludi, Saurabh Rohatgi, Matthew E Zygmont, Faisal Khosa, Tarek N Hanna
OBJECTIVE: The objective of the present study is to examine the concordance of facial fracture classifications in patients with trauma who underwent surgery and to assess the epidemiologic findings associated with facial trauma. MATERIALS AND METHODS: Patients with trauma who underwent facial CT examination and inpatient operative intervention during a 1-year period were retrospectively analyzed. Patient demographic characteristics, the mechanism of injury, the radiology report, the surgical diagnosis, and clinical indications were reviewed...
August 24, 2016: AJR. American Journal of Roentgenology
Lonneke van der Linden, Andrea H L Bruning, Xiomara V Thomas, René P Minnaar, Sjoerd P H Rebers, J Schinkel, Menno D de Jong, Dasja Pajkrt, Katja C Wolthers
OBJECTIVES: Rhinoviruses (RVs) are frequently detected respiratory viruses that cause mild common cold symptoms, but may also lead to more severe respiratory tract infections. The large number of RV types, classified into species A, B and C, hampers clear insights in the epidemiology and clinical significance of each RV type. The aim of this study was to map the circulation of RV types in the Amsterdam area. METHODS: RV-positive naso- and oropharyngeal samples, collected from 2007-2012 in the Academic Medical Center (Amsterdam, the Netherlands), were typed based on the sequence of the region coding for capsid proteins VP4 and VP2...
August 20, 2016: Clinical Microbiology and Infection
Luigi Marano, Alessandro Cecchi, Federica Chiodo, Francesco Gullo, Pasquale Fiorillo, Luca Roncetti, Mattia Longaroni, Gianluca Proietti Silvestri, Silvano Lolli, Giorgio Nicolic, Alberto Patriti
BACKGROUND: In the medical literature are described only few clinical cases of esophageal food bolus impaction due to esophageal motility disorders. Moreover, the management of this condition is highly variable with no evidence in the literature to strongly support a clear defined intervention. CASE PRESENTATION: In this paper we describe for the first time a case of 53-year-old male with food bolus impaction due to Jackhammer esophagus referred to emergency department...
2016: BMC Gastroenterology
L Calo', U Vertolli, E Pagnin, V Ravarotto, E Naso, G Maiolino, A Naso
OBJECTIVE: Cardiovascular disease (CVD) is the leading cause of excess mortality in chronic kidney disease (CKD) and dialysis patients (DP) who have higher prevalence of left ventricular hypertrophy (LVH), the strongest predictor of CV events. Rho kinase (ROCK) activation is linked in hypertensive patients to cardiac remodeling while ROCK inhibition suppresses cardiomyocyte hypertrophy and, in a human model opposite to hypertension such as Bartter's/Gitelman's syndromes patients, its downregulation associates with lack of CV remodeling...
September 2016: Journal of Hypertension
Yi Xu, Yue Mu, Renji Chen, Zongmei Zheng
The isolated naso-ocular cleft is rare. In this article, the authors report an extremely rare case of unilateral isolated naso-ocular cleft. And a new rotation-advancement technique was used in repair. Result was satisfied, especially the esthetical scar location. But if an upper lid flap was performed simultaneously, the result should be better.
October 2016: Journal of Craniofacial Surgery
Mateus R Beguelini, Cintia C I Puga, Eliana Morielle-Versute, Sebastião R Taboga
In eutherian mammals, the male reproductive accessory glands (RAGs) comprise the prostate, bulbourethral glands, ampullary glands, and the seminal vesicles. Their composition, anatomy and function vary widely between species. This study aimed to characterize histologically and compare the RAGs of bats. The RAGs of Noctilio albiventris (Noctilionidae) and Rhynchonycteris naso (Emballonuridae) were studied using anatomical and histological methods, and were reconstructed three dimensionally. The RAGs of N. albiventris and R...
November 2016: Journal of Morphology
Emily Rowlinson, Erica Dueger, Adel Mansour, Nahed Azzazy, Hoda Mansour, Lisa Peters, Summer Rosenstock, Sarah Hamid, Mayar M Said, Mohamed Geneidy, Monier Abd Allah, Amr Kandeel
INTRODUCTION: Acute Respiratory Infections (ARI) are responsible for nearly two million childhood deaths worldwide. A limited number of studies have been published on the epidemiology of viral respiratory pathogens in Egypt. METHODS: A total of 6113 hospitalized patients >1 month of age with suspected ARI were enrolled between June 23, 2009 and December 31, 2013. Naso-and oropharyngeal specimens were collected and tested for influenza A and B, respiratory syncytial virus, human metapneumovirus, adenovirus, and parainfluenza viruses 1-3...
July 26, 2016: Influenza and Other Respiratory Viruses
Marco Merlo, Marco Anzini, Rossana Bussani, Jessica Artico, Giulia Barbati, Davide Stolfo, Marta Gigli, Matilda Muça, Paola Naso, Federica Ramani, Andrea Di Lenarda, Bruno Pinamonti, Gianfranco Sinagra
Dilated cardiomyopathy (DC) is the final common pathway of different pathogenetic processes and presents a significant prognostic heterogeneity, possibly related to its etiologic variety. The characterization and long-term prognosis of postmyocarditic dilated cardiomyopathy (PM-DC) remain unknown. This study assesses the clinical-instrumental evolution and long-term prognosis of a large cohort of patients with PM-DC. We analyzed 175 patients affected with DC consecutively enrolled from 1993 to 2008 with endomyocardial biopsy (EMB) data available...
September 15, 2016: American Journal of Cardiology
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