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https://www.readbyqxmd.com/read/29773323/primary-laryngeal-tuberculosis-our-experiences-at-a-tertiary-care-teaching-hospital-in-eastern-india
#1
Santosh Kumar Swain, Ishwar Chandra Behera, Mahesh Chandra Sahu
INTRODUCTION: Primary laryngeal tuberculosis is a chronic bacterial infection of the larynx by Mycobacterium tuberculosis without affecting the lungs. It is a rare type of extrapulmonary tuberculosis seen in clinical practice. OBJECTIVES: This study aimed to evaluate the clinical presentation, diagnosis, and treatment of primary laryngeal tuberculosis at a tertiary care teaching hospital in eastern India. MATERIALS AND METHODS: This is a retrospective study of 11 cases of primary laryngeal tuberculosis managed between December 2013 and January 2018...
May 14, 2018: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/29771703/a-fatal-outcome-of-pica-syndrome-an-unusual-case-of-delayed-mortality
#2
Milenko Bogdanovic, Djordje Alempijevic, Djordje Curcic, Tijana Durmic
We present the case of a 42-year-old man, with a medical history of schizophrenic psychosis, who was found dead on the floor of his bedroom. At the autopsy, a bottle lid with a notched edge was found in the lower pharynx, partially obstructing the larynx and thus keeping the epiglottis in an open position. Airway obstruction was caused by edema and inflammation of the surrounding tissue. After removal of the foreign body, the tissue of the larynx was left with an impression of the bottle lid. The adjacent mucosa was swollen, hyperemic, partly necrotic, and covered with fibrin deposits...
May 16, 2018: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/29771048/-clinical-analysis-of-differentiated-thyroid-carcinoma-invading-larynx-and-tracheal-esophagus
#3
A M Chen, X Y Luo
No abstract text is available yet for this article.
May 20, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29770611/the-changing-aetiology-of-head-and-neck-squamous-cell-cancer-a-tale-of-three-cancers
#4
Steven J Thomas, Chris M Penfold, Andrea Waylen, Andrew R Ness
Head and neck cancers are the sixth most common cancers worldwide and an important cause of ill health.(1) Each year about 9000 cases are reported in the UK.(2) Survival is poor and despite advances in treatment, has not improved until recently.(3) The majority of head and neck cancers are squamous cell carcinomas, affecting the larynx, oropharynx and oral cavity. The aetiology is changing and this has implications for prevention and treatment. Twenty years ago, tobacco and alcohol consumption were considered to be the established risk factors and it was estimated that these risk factors accounted for about 75% of cases...
May 16, 2018: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29769101/a-new-strategy-for-volumetric-modulated-arc-therapy-planning-using-autoplanning-based-multicriteria-optimization-for-nasopharyngeal-carcinoma
#5
Juanqi Wang, Zhi Chen, Weiwei Li, Wei Qian, Xiaosheng Wang, Weigang Hu
BACKGROUND: A new strategy for making the appropriate choice of the representative optimization parameters in planning processes and accurate selection criteria during Pareto surface navigation for general multicriteria optimization (MCO) was recommended in the study. The purpose was to combine both benefits of AutoPlanning optimization and MCO (APMCO) for achieving an individual volumetric-modulated arc therapy (VMAT) plan according to the clinically achieved patient-specific tradeoff among conflicting priorities...
May 16, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29768641/-the-role-of-elective-neck-dissection-during-salvage-laryngectomy-a-retrospective-analysis
#6
Timon Hussain, Oliver Kanaan, Benedikt Höing, Nina Dominas, Stephan Lang, Stefan Mattheis
Elective neck dissection of the N0-neck is routinely performed during salvage laryngectomy (SLE) for recurrent cancer of the larynx or hypopharynx. The therapeutic benefit of additional neck dissection must be weighed against the risk of increased morbidity. In this retrospective analysis, we assessed oncologic parameters of patients who underwent SLE with concurrent bilateral neck dissection for recurrent laryngeal or hypopharyngeal cancer. We compared these data with patients who underwent primary laryngectomy (LE) with bilateral neck dissection for laryngeal and hypopharyngeal cancer...
May 16, 2018: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/29765635/poor-neuro-motor-tuning-of-the-human-larynx-a-comparison-of-sung-and-whistled-pitch-imitation
#7
Michel Belyk, Joseph F Johnson, Sonja A Kotz
Vocal imitation is a hallmark of human communication that underlies the capacity to learn to speak and sing. Even so, poor vocal imitation abilities are surprisingly common in the general population and even expert vocalists cannot match the precision of a musical instrument. Although humans have evolved a greater degree of control over the laryngeal muscles that govern voice production, this ability may be underdeveloped compared with control over the articulatory muscles, such as the tongue and lips, volitional control of which emerged earlier in primate evolution...
April 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/29765265/is-volumetric-modulated-arc-therapy-with-constant-dose-rate-a-valid-option-in-radiation-therapy-for-head-and-neck-cancer-patients
#8
Annamaria Didona, Valentina Lancellotta, Claudio Zucchetti, Bianca Moira Panizza, Alessandro Frattegiani, Martina Iacco, Anna Concetta Di Pilato, Simonetta Saldi, Cynthia Aristei
Background: Intensity-modulated radiotherapy (IMRT) improves dose distribution in head and neck (HN) radiation therapy. Volumetric-modulated arc therapy (VMAT), a new form of IMRT, delivers radiation in single or multiple arcs, varying dose rates (VDR-VMAT) and gantry speeds, has gained considerable attention. Constant dose rate VMAT (CDR-VMAT) associated with a fixed gantry speed does not require a dedicated linear accelerator like VDR-VMAT. The present study explored the feasibility, efficiency and delivery accuracy of CDR-VMAT, by comparing it with IMRT and VDR-VMAT in treatment planning for HN cancer...
May 2018: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/29764014/-comprehensive-treatment-of-335-patients-with-pyriform-sinus-carcinoma-by-surgery-via-the-paraglottic-space-approach
#9
W M Li, D M Wei, Y Qian, S D Cao, Y Xu, D Y Liu, D P Lei, X L Pan
Objective: To report the experience in comprehensive surgical treatment of pyriform sinus carcinoma via the paraglottic space approach. Methods: Three hundred and thirty-five cases with pyriform sinus carcinoma (according to UICC 2012 criteria, stage Ⅰ, 12 cases; Ⅱ, 36; Ⅲ, 79; Ⅳ, 208; T1, 26; T2, 139; T3, 121; T4, 49; cN0, 83; cN1, 61; cN2a-b, 118; cN2c, 71; cN3, 2) treated between 2006 and 2013 were retrospectively reviewed. There were 323 males and 12 females. Age aged from 36 to 80 years old with a median of 60 years old...
May 7, 2018: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/29763253/croup-diagnosis-and-management
#10
Dustin K Smith, Andrew J McDermott, John F Sullivan
Croup is a common respiratory illness affecting 3% of children six months to three years of age. It accounts for 7% of hospitalizations annually for fever and/or acute respiratory illness in children younger than five years. Croup is a manifestation of upper airway obstruction resulting from swelling of the larynx, trachea, and bronchi, leading to inspiratory stridor and a barking cough. Many patients experience low-grade fevers, but fever is not necessary for diagnosis. Less commonly, stridor can be associated with acute epiglottitis, bacterial tracheitis, and foreign body airway obstruction...
May 1, 2018: American Family Physician
https://www.readbyqxmd.com/read/29761077/anatomical-cadaver-study-of-endolaryngeal-vascularization-focus-on-the-glottis-supraglottis-and-subglottis-from-the-transoral-microsurgical-point-of-view
#11
Pietro Perotti, Marco Ferrari, Nausica Montalto, Davide Lancini, Alberto Paderno, Fabiola Incandela, Barbara Buffoli, Luigi Fabrizio Rodella, Cesare Piazza
Introduction: Carbon dioxide laser coagulation during transoral laser microsurgery (TLM) for laryngeal cancer allows control of bleeding from vessels smaller than 0.5 mm. Therefore, larger arteries and veins must be carefully managed by clipping and/or monopolar cautery. The aim of this paper is to detail endolaryngeal vascular anatomy and identify areas of possible bleeding during TLM. Methods: We performed an anatomical study on a series of 11 fresh-frozen human cadavers...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29760831/current-status-of-organ-preservation-in-carcinoma-larynx
#12
REVIEW
Tapesh Bhattacharyya, Cessal Thommachan Kainickal
Organ preservation in carcinoma larynx is a long debated topic. There are multiple organ preserving approaches in the management of carcinoma larynx depending on various factors. Radical radiotherapy (RT) and conservation laryngeal surgery have shown equivalent results in early laryngeal cancer. Concurrent chemoradiation (CTRT) is the standard treatment in stage III and IV laryngeal cancer with intact cartilage and functional larynx. Patients with cartilage destruction or dysfunctional larynx are not the candidates for organ preservation...
April 2018: World Journal of Oncology
https://www.readbyqxmd.com/read/29760397/automatic-anatomical-classification-of-esophagogastroduodenoscopy-images-using-deep-convolutional-neural-networks
#13
Hirotoshi Takiyama, Tsuyoshi Ozawa, Soichiro Ishihara, Mitsuhiro Fujishiro, Satoki Shichijo, Shuhei Nomura, Motoi Miura, Tomohiro Tada
The use of convolutional neural networks (CNNs) has dramatically advanced our ability to recognize images with machine learning methods. We aimed to construct a CNN that could recognize the anatomical location of esophagogastroduodenoscopy (EGD) images in an appropriate manner. A CNN-based diagnostic program was constructed based on GoogLeNet architecture, and was trained with 27,335 EGD images that were categorized into four major anatomical locations (larynx, esophagus, stomach and duodenum) and three subsequent sub-classifications for stomach images (upper, middle, and lower regions)...
May 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29756613/neutrophil-to-lymphocyte-ratio-as-a-prognostic-factor-for-pharyngocutaneous-fistula-after-total-laryngectomy
#14
F T Aires, R A Dedivitis, M A V Kulcsar, D M Ramos, C R Cernea
The role of systemic inflammatory response as a prognostic factor has been proposed in a variety of cancers. The purpose of this study was to investigate the prognostic value of the pretreatment neutrophil-to-lymphocyte ratio (NLR) in the incidence of pharyngocutaneous fistula (PCF) in patients who underwent total laryngectomy. We conducted a retrospective cohort analysis of 141 patients with squamous cell carcinoma of larynx who underwent total laryngectomy from 2009 to 2015. The incidence of PCF was 49.6%...
February 2018: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/29756612/cancer-of-the-head-and-neck-a-set-of-indicators-based-on-register-and-administrative-data
#15
A Andreano, M Ansarin, D Alterio, R Bruschini, M G Valsecchi, A G Russo
Head and neck (H&N) tumours are a heterogeneous group of neoplasms with 5-year relative survival ranging from about 25% for the hypopharynx to 60% for the larynx in Europe. To improve survival rates, along with therapeutic improvements, it is important to standardise and optimise care received by patients with H&N tumours across different healthcare providers. To reach this goal, it is necessary to evaluate adherence to standards of received care at a population level. Published guidelines can serve as the basis to develop indicators, which can be computed from administrative health databases, measuring the adherence to specific recommendations at the individual level in unselected H&N cancer patients, identified from a population cancer register...
February 2018: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/29756307/age-adjusted-comorbidity-and-survival-in-locally-advanced-laryngeal-cancer
#16
Collin F Mulcahy, Abdallah S R Mohamed, Aasheesh Kanwar, Katherine A Hutcheson, Alokananda Ghosh, David Vock, Randal S Weber, Stephen Y Lai, Gary Brandon Gunn, Mark Zafereo, William H Morrison, Renata Ferrarotto, Adam S Garden, David I Rosenthal, Clifton D Fuller
BACKGROUND: The purpose of this study was to quantify the relationship among age, pretreatment comorbidity, and survival outcomes in patients with locally advanced laryngeal cancer. METHODS: Baseline comorbidity data were collected and age-adjusted Charlson Comorbidity Index (CCI) was calculated for each case. Kaplan-Meier and Cox proportional hazards modeling were used to determine associations with survival. RESULTS: For 548 patients, with a median age of 59 years (range 31-91 years), 58% were treated with larynx preservation and the rest with total laryngectomy and adjuvant radiotherapy (RT)...
May 13, 2018: Head & Neck
https://www.readbyqxmd.com/read/29752322/nccn-guidelines-insights-head-and-neck-cancers-version-1-2018
#17
A Dimitrios Colevas, Sue S Yom, David G Pfister, Sharon Spencer, David Adelstein, Douglas Adkins, David M Brizel, Barbara Burtness, Paul M Busse, Jimmy J Caudell, Anthony J Cmelak, David W Eisele, Moon Fenton, Robert L Foote, Jill Gilbert, Maura L Gillison, Robert I Haddad, Wesley L Hicks, Ying J Hitchcock, Antonio Jimeno, Debra Leizman, Ellie Maghami, Loren K Mell, Bharat B Mittal, Harlan A Pinto, John A Ridge, James Rocco, Cristina P Rodriguez, Jatin P Shah, Randal S Weber, Matthew Witek, Frank Worden, Weining Zhen, Jennifer L Burns, Susan D Darlow
The NCCN Guidelines for Head and Neck (H&N) Cancers provide treatment recommendations for cancers of the lip, oral cavity, pharynx, larynx, ethmoid and maxillary sinuses, and salivary glands. Recommendations are also provided for occult primary of the H&N, and separate algorithms have been developed by the panel for very advanced H&N cancers. These NCCN Guidelines Insights summarize the panel's discussion and most recent recommendations regarding evaluation and treatment of nasopharyngeal carcinoma...
May 2018: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29748451/assessment-of-short-term-functional-voice-therapy-in-patients-with-unilateral-paralysis-of-the-larynx
#18
Paulina Krasnodębska, Anna Domeracka-Kołodziej, Agata Szkiełkowska, Aleksandra Panasiewicz, Marzena Mularzuk, Dorota Sokołowska-Łazar, Karina Wilhelmsen
Introduction Laryngeal paralysis deteriorates all laryngeal functions. Therefore the therapeutic process must include restoration of respiratory, defensive and vocal function. Selection of a proper rehabilitation path plays a key role. Appropriate research protocol that includes objective methods of voice evaluation is an important element of monitoring the return of vocal efficiency. Voice efficiency is important for the patient particularly due to psychological and social reasons. Aim The aim of the study was the assessment of short-term functional voice therapy (FVT) in patients with unilateral paralysis of the larynx with the usage of objective parameters describing the glottis and voice quality...
April 30, 2018: Otolaryngologia Polska
https://www.readbyqxmd.com/read/29747253/-expression-and-significance-of-c-fos-in-resistant-cell-line-tu177-vcr-of-larynx-squamous-cell-carcinoma
#19
G D Li, X L Hu, J F Xing, R Y Shi, X Li, J F Li, T L Li
Objective: To explore the effect of c-fos on multidrug resistance of laryngeal cancer TU177 cells. Method: Increasing drug concentration gradient is adopted to establish the stability of the laryngeal cancer drug resistance in cell line; RT-PCR and Western blot were used to detect difference of the c-fos between TU177 and TU177/VCR cells; plasmids with human c-fos knockdown or over expression were transfected into TU177/VCR and TU177 cells respectively, and the effects of different treatment on cell proliferation were investigated with MTT...
April 7, 2018: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/29744825/adult-type-rhabdomyoma-of-the-larynx-in-birt-hogg-dub%C3%A3-syndrome-evidence-for-a-real-association
#20
Ramkishan Balakumar, Matthew R B Farr, Malee Fernando, Ala Jebreel, Jaydip Ray, Sara Sionis
The autosomal dominant Birt-Hogg-Dubé syndrome is known to be associated with skin, lung and kidney lesions. It is caused by heterozygous germline mutations in the folliculin gene and has a high penetrance. We report the case of a 51 year old woman with Birt-Hogg-Dubé syndrome who presented with a laryngeal mass. Imaging confirmed a mass centered on the piriform sinus and following excision histological examination confirmed the lesion was composed of polygonal cells with abundant eosinophilic cytoplasm consistent with a rhabdomyoma...
May 9, 2018: Head and Neck Pathology
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