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https://www.readbyqxmd.com/read/28930846/cancer-risk-in-patients-with-diabetic-nephropathy-a-retrospective-cohort-study-in-hong-kong
#1
Chi Yuen Cheung, Maggie Kam Man Ma, Wai Leung Chak, Sydney Chi Wai Tang
Diabetic nephropathy (DN) is a leading cause of end-stage kidney disease nowadays. Certain cancers are more common in patients with diabetes mellitus. However, there are no data concerning the cancer pattern in patients with DN. The aim of this study is to investigate the site-specific cancer risk and mortality in these patients.A retrospective cohort study of 5643 DN patients between 2000 and 2015 was conducted in 2 large hospitals in Hong Kong. Incidence and mortality of various cancers were compared with those of general population using standardized incidence ratios (SIRs) and standardized mortality ratios (SMRs) respectively...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28918176/ninety-day-mortality-after-radical-radiotherapy-for-head-and-neck-cancer
#2
L Dixon, K Garcez, L W Lee, A Sykes, N Slevin, D Thomson
AIMS: Treatment for head and neck cancers using definitive radiotherapy, with or without chemotherapy, is associated with significant acute toxicity. Our aim was to assess 90 day mortality after radical radiotherapy. A further aim was to identify patient, tumour or treatment factors associated with early death after treatment and whether these could be used to predict outcomes. MATERIALS AND METHODS: In total, 1116 patients with squamous cell pharyngeal and larynx cancer between January 2011 and December 2015 were included...
September 13, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28916222/estimating-vocal-effort-from-the-aerodynamics-of-labial-fricatives-a-feasibility-study
#3
Yohann Meynadier, Anita El Hajj, Michel Pitermann, Thierry Legou, Antoine Giovanni
OBJECTIVE AND HYPOTHESIS: Vocal effort in loud voice is produced with increased subglottal pressure during vowels and increased supraglottal pressure during consonants. In the paper, our main objective is to check whether it was supported by a parallel increase in the airflow resistance of the laryngeal articulator and of the supralaryngeal articulator, here the lips. STUDY DESIGN AND METHOD: For this comparison, our choice fell on the fricative consonants, as their production allows perfectly synchronous air pressure and airflow measurements...
September 12, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28915289/mild-to-moderate-dysphagia-following-very-low-dose-abobotulinumtoxin-a-for-platysmal-bands
#4
Suzan Obagi, Kseniya Golubets
Onabotulinumtoxin A (Botox) can be a safe and successful off-label treatment of vertical platysma bands of various severities. Due to risk of the botulinum toxin diffusing to the underlying anatomic structures such as the deglutition muscles, the larynx, and the neck flexors, a maximal dose of 100 units has been suggested and there have been no known reports of untoward effects with doses less than 60 units. We present a case of mild to moderate dysphagia in a patient after very low doses of Abobutulinumtoxin (60 units, equivalent to 20 units of Onabotulinumtoxin using a 3:1 conversion ratio)...
September 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28911982/upper-aerodigestive-tract-cancer-and-oral-health-status-before-radiotherapy-a-cross-sectional-study-of-154-patients
#5
A Raskin, M Ruquet, L Weiss-Pelletier, J Mancini, O Boulogne, J Michel, N Fakhry, J M Foletti, C Chossegros, R Giorgi
OBJECTIVES: We aimed to determine primarily the oral health status of patients with upper aerodigestive tract cancer before radiotherapy, and secondarily the prevalence of risk factors for poor oral status. METHODS: A cross-sectional study was conducted in Marseille University hospital. Assessment criteria were the Decay, Missing and Filled (DMF) index and periodontal status. RESULTS: One hundred and fifty-four patients, mean age 60.9 years, were included...
September 11, 2017: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28894827/the-genetic-landscape-of-programmed-death-ligand-1-pd-l1-alterations-in-head-and-neck-cancer
#6
Thomas E Heineman, Adam Widman, Edward C Kuan, Maie St John
OBJECTIVES: Nivolumab has recently been shown in the phase III clinical trial CheckMate-141 to have superior survival rates compared to the current standard of care chemotherapy for recurrent or metastatic platinum-resistant head and neck squamous cell carcinoma (HNSCC). Nivolumab targets the immune inhibitory receptor programmed cell death 1 (PD-1). Programmed cell death ligand 1 (PD-L1) genomics have been poorly characterized in the context of HNSCC, including expression levels of PD-L1 in individual tumors as well as related up or down-regulated genes that might function as co-targets...
June 2017: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/28892942/multifocal-presentation-of-a-laryngeal-disorder
#7
T K Prakash, S Abhilash, G Rajeshwari, H Sundararaju
Multifocal presentation of a laryngeal disorder is very rare. We report a case of a 48-year-old man, who presented to our hospital with hoarse voice for two years. Stroboscopic evaluation followed by surgery was done and the specimens were sent for histopathological examination from three different anatomical sites of larynx which were diagnosed as one-benign lesion, second-benign lesion but ability of malignant transformation and the third-a malignancy.
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28891595/the-effect-of-bolus-volume-on-laryngeal-closure-and-ues-opening-in-swallowing-kinematic-analysis-using-320-row-area-detector-ct-study
#8
Seiko Shibata, Yoko Inamoto, Eiichi Saitoh, Hitoshi Kagaya, Yoichiro Aoyagi, Kikuo Ota, Ryoko Akahori, Naoko Fujii, Jeffrey B Palmer, Marlis Gonzalez Fernandez
This study investigated the effects of three different volumes of honey-thick liquid on the temporal characteristics of swallowing. Twenty six healthy subjects (15 males, 11 females) underwent 320-Row Area Detector CT scan while swallowing 3, 10, and 20ml of honey-thick liquid barium. Three-dimensional images were created at 10 images/s. Kinematic events involving six structures (velopharynx, hyoid bone, epiglottis, laryngeal vestibule (LV), true vocal cords (TVC), upper esophageal sphincter (UES)) and timing of bolus movement were timed using frame by frame analysis...
September 11, 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/28891406/clinical-practice-guideline-evaluation-of-the-neck-mass-in-adults
#9
Melissa A Pynnonen, M Boyd Gillespie, Benjamin Roman, Richard M Rosenfeld, David E Tunkel, Laura Bontempo, Itzhak Brook, Davoren Ann Chick, Maria Colandrea, Sandra A Finestone, Jason C Fowler, Christopher C Griffith, Zeb Henson, Corinna Levine, Vikas Mehta, Andrew Salama, Joseph Scharpf, Deborah R Shatzkes, Wendy B Stern, Jay S Youngerman, Maureen D Corrigan
Objective Neck masses are common in adults, but often the underlying etiology is not easily identifiable. While infections cause most of the neck masses in children, most persistent neck masses in adults are neoplasms. Malignant neoplasms far exceed any other etiology of adult neck mass. Importantly, an asymptomatic neck mass may be the initial or only clinically apparent manifestation of head and neck cancer, such as squamous cell carcinoma (HNSCC), lymphoma, thyroid, or salivary gland cancer. Evidence suggests that a neck mass in the adult patient should be considered malignant until proven otherwise...
September 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28891238/excised-larynx-evaluation-of-subthyroid-cartilage-approach-to-medialization-thyroplasty
#10
James D Thompson, Matthew R Hoffman, Austin Scholp, Erin E Devine, Jack J Jiang, Timothy M McCulloch
OBJECTIVES/HYPOTHESIS: To describe an alternative approach to medialization thyroplasty involving dissection underneath the thyroid cartilage with placement of a Gore-Tex implant, and to evaluate its effect on a range of phonatory measures using an excised canine larynx model. STUDY DESIGN: Animal model. METHODS: On each of eight excised canine larynges, the conditions of normal, paralysis, medialization thyroplasty by standard transthyroid cartilage approach, and medialization thyroplasty by experimental subthyroid cartilage approach were performed...
September 11, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28890113/relationship-between-swallowing-function-and-breathing-phonation
#11
Satoshi Yamaguchi, Mariko Ishida, Kanako Hidaka, Shinya Gomi, Sachiyo Takayama, Kazuki Sato, Yuma Yoshioka, Nozomu Wakayama, Kuwon Sekine, Shoji Matsune, Toshiaki Otsuka, Kimihiro Okubo
OBJECTIVE: Clarification of the association between the swallowing function and respiratory and phonatory functions. METHODS: The subjects were 30 patients with a chief complaint of swallowing disorder with clear consciousness capable of retaining a sitting position. Patients with organic and functional diseases of the larynx were excluded. Twenty-two and eight patients were male and female, respectively, and the mean age was 77.0±14.6years old. The chest expansion score was measured as an index of the respiratory function, and the maximum phonation time (MPT) was measured as an index of the phonatory function...
September 7, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28889105/inducible-laryngeal-obstruction-an-official-joint-european-respiratory-society-and-european-laryngological-society-statement
#12
Thomas Halvorsen, Emil Schwarz Walsted, Caterina Bucca, Andrew Bush, Giovanna Cantarella, Gerhard Friedrich, Felix J F Herth, James H Hull, Harald Jung, Robert Maat, Leif Nordang, Marc Remacle, Niels Rasmussen, Janet A Wilson, John-Helge Heimdal
Inducible laryngeal obstruction (ILO) describes an inappropriate, transient, reversible narrowing of the larynx in response to external triggers. ILO is an important cause of a variety of respiratory symptoms and can mimic asthma. Current understanding of ILO has been hampered by imprecise nomenclature and variable approaches to assessment and management. A task force of the European Respiratory Society (ERS) and European Laryngological Society (ELS) was thus set up to address this, and to identify research priorities...
September 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28887707/correlations-between-patient-reported-dysphagia-screening-and-penetration-aspiration-scores-in-head-and-neck-cancer-patients-post-oncological-treatment
#13
Johanna Hedström, Lisa Tuomi, Caterina Finizia, Caroline Olsson
Dysphagia is a common and severe toxicity after oncological treatment of head and neck cancer (HNC). The study aim was to investigate relationships between patient-reported dysphagia and clinically measured swallowing function in HNC after modern curative radiotherapy with or without chemotherapy to identify possible alarm symptoms for clinically manifest dysphagia. Patients with tumors of the tonsil, base of tongue, hypopharynx, and larynx treated in 2007-2015 were assessed for dysphagia post-treatment by telephone interview and videofluoroscopy (VFS)...
September 8, 2017: Dysphagia
https://www.readbyqxmd.com/read/28885660/cortactin-and-phosphorylated-cortactin-tyr421-and-tyr466-expression-in-supraglottic-laryngeal-carcinomas-and-lymph-node-metastases
#14
Gino Marioni, Marco Lionello, Rosario Marchese-Ragona, Elena Fasanaro, Elisa Valentini, Elisabetta Zanoletti, Paola Stritoni, Giulia Ramacciotti, Vincenza Guzzardo, Luciano Giacomelli, Giovanni Ralli, Giancarlo Ottaviano, Stella Blandamura
BACKGROUND: The most important adverse prognostic factor for laryngeal squamous cell carcinoma (LSCC) is the presence of cervical lymph node metastases. The supraglottic area of the larynx is richly supplied with lymphatics, and 25%-75% of supraglottic carcinomas metastasize in neck lymph nodes. Cortactin is a multidomain protein related to actin cytoskeleton regulation, podosome and lamellipodia formation, integrin signaling, axon guidance and extracellular matrix degradation. Cortactin is involved in metastasis formation because of its role in cell mobility...
September 5, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/28884075/laryngeal-paralysis-associated-with-a-muscle-pseudotumour-in-a-young-dog
#15
Francesca Rizzo, Cecilia Benetti, Consuelo Ballatori, Diana Binanti
An 18-month-old male entire Bloodhound dog was presented with a six-week history of progressive inspiratory dyspnoea, stridor, dysphonia and exercise intolerance. CT scan performed elsewhere had revealed the presence of an unencapsulated nodular mass (3x1x5 cm) dorsal to the larynx and first tracheal rings. Laryngoscopy demonstrated the presence of bilateral laryngeal paralysis and distorted laryngeal architecture suggestive of extraluminal compression. Histopathology results of incisional biopsies from the mass were suggestive of a benign non-neoplastic muscular lesion...
2017: Open veterinary journal
https://www.readbyqxmd.com/read/28878980/the-origins-of-babytalk-smiling-teaching-or-social-convergence
#16
Marina Kalashnikova, Christopher Carignan, Denis Burnham
When addressing their young infants, parents systematically modify their speech. Such infant-directed speech (IDS) contains exaggerated vowel formants, which have been proposed to foster language development via articulation of more distinct speech sounds. Here, this assumption is rigorously tested using both acoustic and, for the first time, fine-grained articulatory measures. Mothers were recorded speaking to their infant and to another adult, and measures were taken of their acoustic vowel space, their tongue and lip movements and the length of their vocal tract...
August 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28878850/difference-in-f-18-fdg-uptake-after-esophagogastroduodenoscopy-and-colonoscopy-in-healthy-sedated-subjects
#17
Jong-Ryool Oh, Ji-Hyoung Seo, Woo-Jin Chang, Seung-Il Bae, In-Wook Song, Jin-Gu Bong, Hye-Yeon Jeong, So-Young Park, Jeongyup Bae, Hyundae Yoon
PURPOSE: We aimed to evaluate the difference in fluorodeoxyglucose (FDG) uptake in sedated healthy subjects after they underwent esophagogastroduodenoscopy (EGD) and colonoscopy procedures. METHODS: The endoscopy group (n = 29) included healthy subjects who underwent screening via F-18 FDG positron emission tomography/computed tomography (PET/CT) after an EGD and/or colonoscopy under sedation on the same day. The control group (n = 35) included healthy subjects who underwent screening via PET/CT only...
September 2017: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28875540/the-physiological-motor-patterns-produced-by-neurons-in-the-nucleus-retroambiguus-in-the-rat-and-their-modulation-by-vagal-peripheral-chemosensory-and-nociceptive-stimulation
#18
Hari H Subramanian, Zheng-Gui Huang, Peter A Silburn, Ron J Balnave, Gert Holstege
The nucleus retroambiguus (NRA) is a neuronal cell group in the medullary ventrolateral tegmentum, rostrocaudally between the obex and the first cervical spinal segment. NRA neurons are premotor interneurons with direct projections to the motoneurons of soft palate, pharynx and larynx in the nucleus ambiguus in the lateral medulla as well as to the motoneurons in the spinal cord innervating diaphragm, abdominal, and pelvic floor muscles and the lumbosacral motoneurons generating sexual posture. These NRA premotor interneurons receive very strong projections from the periaqueductal gray (PAG) in the context of basic survival mechanisms as fight, flight, freezing, sound production and sexual behavior...
September 5, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28875091/demographics-of-head-and-neck-cancer-patients-a-single-institution-experience
#19
George S Stoyanov, Martina Kitanova, Deyan L Dzhenkov, Peter Ghenev, Nikolay Sapundzhiev
Introduction Head and neck cancer (HNC) comprises a diverse group of oncological entities, originating from various tissue types and organ localizations, situated in the topographical regions of the head and neck (H&N). This single institution retrospective study was aimed at establishing the HNC patient demographics and categorizing the individual incidence of H&N malignancies, regarding their organ of origin and main histopathological type. Materials and methods All histologically verified cases of HNC from a single tertiary referral center were reviewed in a descriptive retrospective manner...
July 2, 2017: Curēus
https://www.readbyqxmd.com/read/28874852/acoustic-allometry-revisited-morphological-determinants-of-fundamental-frequency-in-primate-vocal-production
#20
Maxime Garcia, Christian T Herbst, Daniel L Bowling, Jacob C Dunn, W Tecumseh Fitch
A fundamental issue in the evolution of communication is the degree to which signals convey accurate ("honest") information about the signaler. In bioacoustics, the assumption that fundamental frequency (f o) should correlate with the body size of the caller is widespread, but this belief has been challenged by various studies, possibly because larynx size and body size can vary independently. In the present comparative study, we conducted excised larynx experiments to investigate this hypothesis rigorously and explore the determinants of f o...
September 5, 2017: Scientific Reports
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