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Phytochemicals

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https://www.readbyqxmd.com/read/29232753/solvent-extraction-and-gc-ms-analysis-of-sesame-seeds-for-determination-of-bioactive-antioxidant-fatty-acid-fatty-oil-components
#1
Abdul Qadir, Athar Ali, Muhammad Arif, Abdulmohsen H Al-Rohaimi, Satya Prakash Singh, Usama Ahmad, Mohd Khalid, Arun Kumar
The seed kernels of Sesamum indicum L. (family: Pedaliaceae) were extracted with ethanol and yield of components determined by Gas Chromatography/Mass Spectrometry (GC/MS). The free radical scavenging activities of ethanolic extract against1, 1-Diphenyl-2-picrylhydrazyl (DPPH) were determined by UV spectrophotometer at 517 nm. Phytochemical screening revealed the presence of numerous bioactive compounds including steroids, phenolic, terpenoids, fatty acids and different types of ester compounds. The ethanolic extract was purified and analyzed by GC MS...
December 12, 2017: Drug Research
https://www.readbyqxmd.com/read/29230630/phytochemical-study-and-evaluation-of-cytotoxicity-mutagenicity-cell-cycle-kinetics-and-gene-expression-of-bauhinia-holophylla-bong-steud-in-hepg2-cells-in-vitro
#2
Diego Luis Ribeiro, Heloísa Lizotti Cilião, Ana Flávia Leal Specian, Juliana Mara Serpeloni, Marcelo Tempesta De Oliveira, Eliana Aparecida Varanda, Wagner Vilegas, Luiz Leonardo Saldanha, Wilner Martínez-López, Anne Lígia Dokkedal, Ilce Mara Syllos Cólus
Bauhinia holophylla (Bong.) Steud. (Fabaceae) is a plant used in Brazilian folk medicine to treat diabetes and inflammation. This study evaluated the phytochemical properties, cytotoxic, apoptotic, mutagenic/antimutagenic effects and alterations in gene expression (RNAm) in HepG2 cells treated with the B. holophylla extract. The phytochemical profile highlight the presence of flavonoids isorhamentin and quercetin derivates. The MTT assay was used to evaluate the cytotoxicity of different concentrations for different treatment times...
December 11, 2017: Cytotechnology
https://www.readbyqxmd.com/read/29228818/evaluation-of-herbal-concoctions-sold-at-ga-maja-limpopo-province-in-south-africa-and-in-vitro-pharmacological-evaluation-of-plants-used-to-manufacture-the-concoctions
#3
Mash M Matotoka, Peter Masoko
The aim of the study was to evaluate the biological activities and safety of commercial herbal concoctions manufactured in Ga Maja (Limpopo province). Microbial contamination was evaluated by spread-plating the concoctions on agar plates. The VITEK 2 instrument was used for identification of the pure cultures. Nutritional content of the concoctions was determined. Thin layer chromatography was used to analyze the chemical constituents of the extracts. The microdilution assay and bioautography were used to evaluate antimicrobial activity against selected microorganisms...
January 1, 2017: Journal of Evidence-based Complementary & Alternative Medicine
https://www.readbyqxmd.com/read/29228808/variation-in-phytochemical-composition-reveals-distinct-divergence-of-aloe-vera-l-burm-f-from-other-aloe-species-rationale-behind-selective-preference-of-aloe-vera-in-nutritional-and-therapeutic-use
#4
Priyankar Dey, Somit Dutta, Anurag Chowdhury, Abhaya Prasad Das, Tapas Kumar Chaudhuri
In the present study, we have phytochemically characterized 5 different abundant Aloe species, including Aloe vera (L.) Burm.f., using silylation followed by Gas Chromatography-Mass Spectrometry technique and compared the data using multivariate statistical analysis. The results demonstrated clear distinction of the overall phytochemical profile of A vera, highlighted by its divergent spatial arrangement in the component plot. Lowest correlation of the phytochemical profiles were found between A vera and A aristata Haw...
January 1, 2017: Journal of Evidence-based Complementary & Alternative Medicine
https://www.readbyqxmd.com/read/29227656/artocarmins-g-m-prenylated-4-chromenones-from-the-stems-of-artocarpus-rigida-and-their-tyrosinase-inhibitory-activities
#5
Mai T T Nguyen, Tho H Le, Hai X Nguyen, Phu H Dang, Truong N V Do, Manabu Abe, Ryukichi Takagi, Nhan T Nguyen
Phytochemical analysis of an EtOAc extract of the stems of Artocarpus rigida led to the identification of seven new prenylated 4-chromenones, artocarmins G-M (1-7), and nine known compounds (8-17). Their structures were identified based on physical data analysis. In the tyrosinase inhibitory activity test, norartocarpetin (8) displayed the strongest effect, with an IC50 value of 0.023 μM.
December 11, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/29227542/characterization-of-peanut-oil-bodies-integral-proteins-lipids-and-their-associated-phytochemicals
#6
Farah Zaaboul, Husnain Raza, Cao Chen, Yuanfa Liu
A microscopic image of a section of a peanut seed shows that oil bodies (OBs) are a small droplet of oil that is dispersed throughout the whole seed. The protein profile of peanut's OBs recovered using the aqueous extraction method at different pH was found to have 2 oleosin isoforms of 14 and 16 kDa. Moreover, OBs essential amino acids are 1.52 higher than those in the PPI. Oleic acid and linoleic acid are the major fatty acids in both cold press peanut oil and OBs regardless of pH. Tocopherol content went from 270...
December 11, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/29226147/antifungal-activity-of-aqueous-extracts-of-some-dominant-algerian-medicinal-plants
#7
Nasrine Salhi, Sultan Ayesh Mohammed Saghir, Valeria Terzi, Iman Brahmi, Naima Ghedairi, Samia Bissati
Aim: This study investigated the antifungal properties of aqueous extracts obtained from indigenous plants that grow spontaneously in the Northern Sahara of Algeria. The activities of these plants in controlling two fungal species that belong to Fusarium genus were evaluated in an in vitro assay. Materials and Methods: Fresh aerial parts of four plant species (Artemisia herba alba, Cotula cinerea, Asphodelus tenuifolius, and Euphorbia guyoniana) were collected for the preparation of aqueous extracts...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29225112/fisetin-a-bioactive-phytochemical-with-potential-for-cancer-prevention-and-pharmacotherapy
#8
REVIEW
Dharambir Kashyap, Ajay Sharma, Katrin Sak, Hardeep Singh Tuli, Harpal Singh Buttar, Anupam Bishayee
A wide variety of chronic diseases, such as neurodegenerative and cardiovascular disorders, diabetes mellitus, osteoarthtitis, obesity and various cancers, are now being treated with cost effective phytomedicines. Since synthetic medicines are very expensive, concerted efforts are being made in developing and poor countries to discover cost effective medicines for the treatment of non-communicable diseases (NCDs). Understanding the underlying mechanisms of bioactive medicines from natural sources would not only open incipient avenues for the scientific community and pharmaceutical industry to discover new drug molecules for the therapy of NCDs, but also help to garner knowledge for alternative therapeutic approaches for the management of chronic diseases...
December 7, 2017: Life Sciences
https://www.readbyqxmd.com/read/29224253/phytochemical-composition-and-biological-activities-of-dyssodia-tagetiflora-lag
#9
Ana María García-Bores, Amira Arciniegas-Arciniegas, Alma Reyna Campos, Carlos Céspedes-Acuña, Betsaida Avila-Suárez, Julio Alarcón-Enos, Saul Flores-Maya, Adriana Montserrat Espinosa-González, Alfonso Romo de Vivar-Romo, Carlos Pérez Plasencia, José Guillermo Avila-Acevedo
While plants of the genus Dyssodia are used by man to a certain extent, few phytochemical and pharmacological studies have been performed with species of this genus. D. tagetiflora is an endemic plant of Mexico and has been used as fodder. The aim of this research was to isolate and identify the main bioactive components and evaluate the insecticidal, antioxidant, genotoxic and cytoprotective activities of D. tagetiflora. The isolated substances included an essential oil composed of six monoterpenes, and extracts containing two flavonols, three flavonol-glycosides and four thiophenes...
December 10, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/29224178/evaluation-of-the-anti-inflammatory-and-urotoxicity-ameliorative-effects-of-%C3%AE-humulene-containing-active-fraction-of-emilia-sonchifolia-l-dc
#10
Gilcy George Kallivalappil, Girija Kuttan
In folklore medicine, the plant Emilia sonchifolia, belonging to the family Asteraceae, is used for treating tumour and inflammation. In our previous studies, we have done a thorough phytochemical investigation of E. sonchifolia with a report on its potent antimetastatic activity. Further, we isolated and characterised its active fraction (AFES) containing the major compound γ-humulene with an evaluation of the antiangiogenic effect of AFES (5 mg/kg b.wt.). In the first part of the present study, AFES in different concentrations was used for the assessment of its possible anti-inflammatory effect employing three in vivo inflammatory models...
December 9, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/29223063/phytochemical-study-of-the-trunk-bark-of-citharexylum-spinosum-l-growing-in-tunisia-isolation-and-structure-elucidation-of-iridoid-glycosides
#11
Ilyes Saidi, Pierre Waffo-Téguo, Asma E L Ayeb-Zakhama, Fethia Harzallah-Skhiri, Axel Marchal, Hichem Ben Jannet
A phytochemical investigation of the trunk bark ethyl acetate extract of Citharexylum spinosum L. has led to the isolation of four previously undescribed iridoid glycosides, tunispinosides A-D, and five known phenylethanoid glycosides, verbascoside, leucosceptoside A, martynoside, isoverbascoside and plantainoside C, together with 4-hydroxy-2,6-dimethoxyphenyl 6'-O-vanilloyl-β-D-glucopyranoside, two 8,3'-neolignan glycosides, plucheosides D1-D2, coniferyl aldehyde, vanillic acid, syringic acid, ferulic acid and tyrosol...
December 6, 2017: Phytochemistry
https://www.readbyqxmd.com/read/29222032/assessment-of-the-laxative-activity-of-an-ethanolic-extract-of-bambusa-arundinacea-retz-willd-shoot
#12
S M Neamul Kabir Zihad, Sanjib Saha, Md Sifujjaman Rony, Hasna Banu, Shaikh J Uddin, Jamil A Shilpi, I Darren Grice
ETHNOBOTANICAL RELEVANCE: Bambusa arundinacea (Retz.) Willd., commonly known as Kanta Bans, plays an important ethnobotanical role, especially in Asia. In traditional medicine it has reportedly been used for the treatment of constipation, blood-diseases, leucodema, inflammation and urinary discharges. A number of ethnomedicinal records exist regarding the use of B. arundinaceae shoots as a laxative, however, there are no scientific studies reported on its laxative activity. Therefore, the aim of this present study was to evaluate the laxative activity of an ethanolic B...
December 5, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29221764/regulation-of-autophagy-by-polyphenols-paving-the-road-for-treatment-of-neurodegeneration
#13
REVIEW
Seyed Fazel Nabavi, Antoni Sureda, Ahmad Reza Dehpour, Samira Shirooie, Ana Sanches Silva, Kasi Pandima Devi, Touqeer Ahmed, Nafeesa Ishaq, Rabia Hashim, Eduardo Sobarzo-Sánchez, Maria Daglia, Nady Braidy, Mariateresa Volpicella, Rosa Anna Vacca, Seyed Mohammad Nabavi
In the present paper, we will discuss on the importance of autophagy in the central nervous system, and outline the relation between autophagic pathways and the pathogenesis of neurodegenerative disorders. The potential therapeutic benefits of naturally occurring phytochemicals as pharmacological modulators of autophagy will also be addressed. Our findings provide renewed insight on the molecular modes of protection by polyphenols, which is likely to be at least in part mediated not only by their potent antioxidant and anti-inflammatory effects, but also through modulation of autophagic processes to remove the aberrant protein aggregates...
December 5, 2017: Biotechnology Advances
https://www.readbyqxmd.com/read/29220106/chemoprevention-by-resveratrol-and-pterostilbene-targeting-on-epigenetic-regulation
#14
REVIEW
Pei-Sheng Lee, Yi-Shiou Chiou, Chi-Tang Ho, Min-Hsiung Pan
Epigenetic mechanisms are essential in regulating normal cellular functions and play an important role during the disease developmental stages. However, aberrant epigenetic mechanisms may lead to pathological consequences such as cancer, neurological disorders, bone and skeletal diseases, cardiovascular dysfunction, and metabolic syndrome. The molecular mechanisms of epigenetic modification include DNA methylation, histone modification (acetylation, methylation and phosphorylation), and microRNAs (miRNAs). Unlike genetic modifications, epigenetic states of genes are reversible and can be altered by certain intrinsic and extrinsic factors...
December 8, 2017: BioFactors
https://www.readbyqxmd.com/read/29217922/effect-of-solanum-nigrun-on-uterus-of-non-gravid-rats
#15
Freddy O Agoreyo, B Rita Ohimai, Magdalene I Omigie
Background: Solanum nigrum is a widely used plant in oriental medicine where it is considered to be antioxidant, anti- inflammatory and diuretic. This study aimed to evaluate the effect of Solanum Nigrum on uterine contractions. Method: Female Wistar Wister albino rats were used for the study. They were housed in a single large cage in an atmospheric controlled environment. Twenty-four hours before every experiment, 0.2 mg/kg of diethylstilbesterol constituted in 1:1 ethanol/water solution, was administered intraperitoneally as a pre-treatment to the rats to induce oestrus...
May 2017: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/29217268/novel-in-vitro-and-in-silico-insights-of-the-multi-biological-activities-and-chemical-composition-of-bidens-tripartita-l
#16
Sengul Uysal, Asli Ugurlu, Gokhan Zengin, Mehmet Cengiz Baloglu, Yasemin Celik Altunoglu, Adriano Mollica, Luisa Custodio, Nuno R Neng, José M F Nogueira, M Fawzi Mahomoodally
Bidens tripartita L. is a traditional phyto-remedy used in several countries, yet there is still a paucity of data on its biological potential. We aimed to provide new insights on the pharmacological potential of extracts prepared from B. tripartita via highlighting its antioxidant, key enzymes inhibitory potency, and DNA protecting effects. Phytochemical profile was established using High-Performance Liquid Chromatography with Diode-Array Detection (HPLC-DAD) and bioactive compound(s) docked against target enzymes using in silico methods...
December 4, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29214921/heteropterys-tomentosa-a-juss-toxicological-and-adaptogenic-effects-in-experimental-models
#17
Géssica Alves Fraga, Sikiru Olaitan Balogun, Emilly Della Pascqua, Ruberlei Godinho de Oliveira, Guilherme Botelho, Eduarda Pavan, Thiago da Rosa Lima, Eudes Thiago Pereira Avila, Clarissa de Medeiros Amorim Krueger, Valdir Cechinel Filho, Amílcar Sabino Damazo, Domingos Tabajara de Oliveira Martins, Fabrício Azevedo Voltarelli
BACKGROUND: The constant pursuit of improved athletic performance characterizes high-performance sport and the use of medicinal plants as dietary supplements is becoming widespread among athletes to enhance long-term endurance performance. AIM: The present study evaluated the toxicity of Heteropterys tomentosa (HEHt) and its acute adaptogenic effects. METHODS: The in vitro safety profile was evaluated on CHO-k1 cells using the alamar Blue assay, at concentrations ranging from 3...
December 2017: Nutrition and Health
https://www.readbyqxmd.com/read/29213351/spondias-purpurea-l-anacardiaceae-antioxidant-and-antiulcer-activities-of-the-leaf-hexane-extract
#18
Cynthia Layse Ferreira de Almeida, Samara Alves Brito, Temístocles Italo de Santana, Henrique Bandeira Alves Costa, Carlson Helder Reis de Carvalho Júnior, Márcia Vanusa da Silva, Lécio Leone de Almeida, Larissa Araújo Rolim, Vanda Lucia Dos Santos, Almir Gonçalves Wanderley, Teresinha Gonçalves da Silva
Spondias purpurea is used in folk medicine to treat diarrhea and diuresis. The objective of this study was to evaluate the phytochemical profile and antioxidant and antiulcer activities of the hexane extract of the leaves of S. purpurea (SpHE). Phytochemical profile was evaluated via thin layer chromatography (TLC) and HPLC. SpHE was screened for antioxidant activities using DPPH, ABTS, FRAP, and phosphomolybdenum assays. To determine its antiulcer properties, animals were pretreated with injured control, lansoprazole, ranitidine, carbenoxolone, or SpHE (12...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29213047/differentially-evolved-glucosyltransferases-determine-natural-variation-of-rice-flavone-accumulation-and-uv-tolerance
#19
Meng Peng, Raheel Shahzad, Ambreen Gul, Hizar Subthain, Shuangqian Shen, Long Lei, Zhigang Zheng, Junjie Zhou, Dandan Lu, Shouchuang Wang, Elsayed Nishawy, Xianqing Liu, Takayuki Tohge, Alisdair R Fernie, Jie Luo
Decoration of phytochemicals contributes to the majority of metabolic diversity in nature, whereas how this process alters the biological functions of their precursor molecules remains to be investigated. Flavones, an important yet overlooked subclass of flavonoids, are most commonly conjugated with sugar moieties by UDP-dependent glycosyltransferases (UGTs). Here, we report that the natural variation of rice flavones is mainly determined by OsUGT706D1 (flavone 7-O-glucosyltransferase) and OsUGT707A2 (flavone 5-O-glucosyltransferase)...
December 7, 2017: Nature Communications
https://www.readbyqxmd.com/read/29210667/nerolidol-and-its-pharmacological-application-in-treating-neurodegenerative-diseases-a-review
#20
Rusbene Bruno Fonseca De Carvalho, Antonia Amanda Cardoso De Almeida, Neylon Barbosa Campelo, Daniel Ramon Oliveira Dantas Lellis, Livio Cesar Cunha Nunes
BACKGROUND: Research on natural bioactive compounds has increased exponentially over the last decades. The discovery of new phytochemicals that possess pharmaceutical properties is useful in the development of therapeutic alternatives. The nerolidol (3,7,11-trimetil-1,6,10-dodecatrien-3-ol or 3,7,11-trimetildodeca-1,6,10-trien-3-ol) has been extensively studied for its therapeutic potential because of its pharmacological activities in the treatment of neurodegenerative diseases. METHODS: All articles and patents regarding to nerolidol and its pharmacological properties were revised, focusing mainly on the important properties in the treatment of neurodegenerative diseases...
December 6, 2017: Recent Patents on Biotechnology
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