keyword
MENU ▼
Read by QxMD icon Read
search

Phytochemicals

keyword
https://www.readbyqxmd.com/read/29028954/1-benzyl-indole-3-carbinol-is-a-highly-potent-new-small-molecule-inhibitor-of-wnt-%C3%AE-catenin-signaling-in-melanoma-cells-that-coordinately-inhibits-cell-proliferation-and-disrupts-expression-of-microphthalmia-associated-transcription-factor-isoform-m
#1
Aishwarya Kundu, Michelle G Khouri, Sheila Aryana, Gary L Firestone
1-Benzyl-indole-3-carbinol (1-benzyl-I3C), a synthetic analogue of the crucifer derived natural phytochemical I3C, displayed significantly wider sensitivity and anti-proliferative potency in melanoma cells than the natural compound. Unlike I3C, which targets mainly oncogenic BRAF-expressing cells, 1-benzyl I3C effectively inhibited proliferation of melanoma cells with a more extensive range of mutational profiles, including those expressing wild type BRAF. In both cultured melanoma cell lines and in vivo in melanoma cell-derived tumor xenografts, 1-benzyl-I3C disrupted canonical Wnt/β-catenin signaling that resulted in the down regulation of β-catenin protein levels with a concomitant increase in levels of the β-catenin destruction complex components GSK3β and Axin...
September 23, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/29027830/occurrence-types-properties-and-interactions-of-phenolic-compounds-with-other-food-constituents-in-oil-bearing-plants
#2
Muhammad H Alu'datt, Taha Rababah, Mohammad N Alhamad, Ghaid J Al-Rabadi, Carole C Tranchant, Ali Almajwal, Stan Kubow, Inteaz Alli
Phenolic phytochemicals have become of interest due to their therapeutic potential, particularly with regards to their anti-cancer, anti-inflammatory, hypolipidemic, and hypoglycemic properties. An evolving area of research involving phenolics in foods and their products pertains to the functional, biological, and nutritional consequences resulting from the binding between certain phenolic compounds and the macronutrient and micronutrient constituents of foods. The goal of this review is to provide a summary of studies investigating endogenous phenolic interactions with major components in food systems, including carbohydrates, proteins, lipids, minerals and vitamins, with a focus on the phenolic compounds and nutrients in oil-bearing plants...
October 13, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29027278/current-status-of-herbal-drug-standards-in-the-indian-pharmacopoeia
#3
REVIEW
Jai Prakash, Sushma Srivastava, R S Ray, Neha Singh, Roshni Rajpali, Gyanendra Nath Singh
The benefits of herbal drugs were well understood way back. They have been used for the promotion of health and medical purposes - in disease conditions. It is a conventional belief that herbal drugs have no side effects, are cheaper and locally available. Among Indian systems of medicines, herbs/herbal formulations are used to a larger extent. The quality control of the marketed herbs/herbal formulations is important for acquiring optimum therapeutic benefit as well as for expanding global outreach. Therefore, herbal drug standards are important...
October 13, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29026858/chemical-constitute-and-larvicidal-activity-of-fractions-of-ajuga-chamaecistus-tomentella-plant-against-malaria-vector-anopheles-stephensi
#4
Mahnaz Khanavi, Behnaz Najafi, Seyede Nargess Sadati, Mohammad Reza Abai, Hassan Vatandoost
BACKGRAND: The genus Ajuga, belongs to Lamiaceae family, is one of the exclusive subspecies in the flora of Iran. The plants of this genus are used traditionally for treatment of joints pain, gout, jaundice, and as insecticide. METHODS: larvicidal activity of methanol 80% extract and partition fractions of hexane, chloroform, and ethyl acetate obtained from aerial parts of Ajuga chamaecistus subspecies tomentella against malaria vector An. stephensi was evaluated...
March 2017: Journal of Arthropod-borne Diseases
https://www.readbyqxmd.com/read/29023845/aqueous-extract-of-gynura-bicolor-attenuated-hepatic-steatosis-glycative-oxidative-and-inflammatory-injury-induced-by-chronic-ethanol-consumption-in-mice
#5
Mei-Chin Yin, Zhi-Hong Wang, Wen-Hu Liu, Mei-Chin Mong
Gynura bicolor leaf aqueous extract (GAE) is rich in phytochemicals including phenolic acids, flavonoids, carotenoids, and anthocyanins. Effects of GAE upon hepatic injury in mice with chronic ethanol intake were examined. Lieber-DeCarli liquid diet with ethanol was used to induce hepatic lipid accumulation, oxidative, glycative, and inflammatory injury. GAE at 0.25% or 0.5% was added in feeds, and supplied to mice consumed Lieber-DeCarli liquid diet with ethanol for 6 wk. Blood and liver were collected for analyses...
October 12, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/29023481/phytochemical-residue-profiles-in-rice-grains-fumigated-with-essential-oils-for-the-control-of-rice-weevil
#6
S Ezhil Vendan, S Manivannan, Anila M Sunny, R Murugesan
In the present study, we investigated the fumigant potential of five edible essential oils (EOs) against Sitophilus oryzae and their phytochemical residues in treated grains. Among the tested EOs, peppermint oil proved significantly effective (P ≤ 0.05) on S.oryzae at 400 μl/L air concentration, inducing 83 and 100% mortalities in with-food and without-food conditions respectively over 72 h exposure. In addition, it was also observed that the binary mixtures of peppermint + lemon oil (1:1 ratio) produced an equivalent effect to that of peppermint oil alone treatments...
2017: PloS One
https://www.readbyqxmd.com/read/29023411/scientific-study-of-gentiana-kurroo-royle
#7
REVIEW
Bhat Mohd Skinder, Bashir Ahmad Ganai, Abdul Hamid Wani
The present investigation was carried out to review and highlight the potential phytochemicals and medicinal phenomena of the critically endangered medicinal plant, Gentiana kurroo Royle of the western and north-western Himalayas. The medicinal plant is heavily exploited for root and rhizome. Due to its endemic nature and the high rate of exploitation from its natural habitat, this species had become critically endangered. The phytochemical screening of the plant revealed that the plant contains some vital phyto-constituents (iridoids, xanthones, C-glucoxanthone mangiferin, and C-glucoflavones) that have a medicinal value for various acute and chronic diseases...
October 12, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/29023401/effects-of-sorghum-malting-on-colour-major-classes-of-phenolics-and-individual-anthocyanins
#8
Ali Khoddami, Mohammad Mohammadrezaei, Thomas H Roberts
Sorghum (Sorghum bicolor) grain contains many health-promoting phytochemicals, including a broad range of phenolic compounds. Malting of cereal grains is known to increase the bioavailability of macro- and micronutrients. However, the detailed effects of malting on sorghum grain anthocyanins, a major class of phenolics that influence the taste and colour of sorghum-based foods, requires further investigation. Eight commercial sorghum hybrids harvested from three regions in eastern Australia were malted and analysed for colour, tannin content, total phenolic content (TPC), flavan-4-ols, total flavonoids, total anthocyanins and 3-deoxyanthocyanins...
October 12, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29022997/phytochemical-analysis-identification-and-quantification-of-antibacterial-active-compounds-in-betel-leaves-piper-betle-methanolic-extract
#9
A Syahidah, C R Saad, M D Hassan, Y Rukayadi, M H Norazian, M S Kamarudin
BACKGROUND AND OBJECTIVE: The problems of bacterial diseases in aquaculture are primarily controlled by antibiotics. Medicinal plants and herbs which are seemed to be candidates of replacements for conventional antibiotics have therefore gained increasing interest. Current study was performed to investigate the presence of phytochemical constituents, antibacterial activities and composition of antibacterial active compounds in methanolic extract of local herb, Piper betle . METHODOLOGY: Qualitative phytochemical analysis was firstly carried out to determine the possible active compounds in P...
2017: Pakistan Journal of Biological Sciences: PJBS
https://www.readbyqxmd.com/read/29022360/new-pyridocarbazole-alkaloids-from-strychnos-nitida
#10
Wei Li, Gui-Hua Tang, Lin Chen, Ya-Qi Tang, You-Kai Xu, Bo Liu, Sheng Yin
Phytochemical investigation of Strychnos nitida has led to the isolation of three new racemic pyridocarbazole alkaloids, (±)-stritidas A-C (1-3) and three known monoterpenoid indole alkaloids (4-6). Compounds 2 and 3 represent the first examples of pyridocarbazole alkaloids featuring an N-2-hydroxyethyl moiety. Their structures were determined by combined spectroscopic data (MS, UV, IR and NMR) and chemical methods.
October 12, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29017076/determination-of-the-phytochemical-composition-of-jingning-fang-and-the-in-vivo-pharmacokinetics-of-its-metabolites-in-rat-plasma-by-uplc-ms-ms
#11
Chunjing Yang, XingBin Yin, Xiaoxv Dong, Xin Zhang, Longtai You, Wenping Wang, Junhong Wang, Qinghe Chen, Jian Ni
Jingning fang (JNF) is an effective Traditional Chinese Medicine (TCM) which is used for the treatment of Attention Deficit Hyperactivity Disorder (ADHD). To clarify the bioactive constituents of JNF, a Thermo Q Exactive™ Plus Orbitrap™ mass spectrometer was used in this study. More than 127 chemical compounds were isolated and identified tentatively in the JNF extract, while 42 prototype constituents with 4 potential metabolites were identified tentatively in rat plasma. A method for simultaneous determination of polygalaxanthone III (PAIII), sibiricose A5 (A5), sibiricose A6 (A6), 3, 6'-disinapoyl sucrose (3,6'-DISS), tenuifoliside C (TEC), tenuifolin B (TNB), verbascoside (VCE), heterophyllin B (HEB) and schisandrin (SCH) in rat was developed and validated using polydatin (PLN) and psoralen (PSN) as internal standards...
September 21, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29017021/chemical-composition-of-the-essential-oils-isolated-from-peel-of-three-citrus-species-and-their-mosquitocidal-activity-against-culex-pipiens
#12
Mohamed E I Badawy, Nehad E M Taktak, Ahmed F El-Aswad
Three essential oils (EOs) were isolated from the peel of citrus fruits Citrus reticulata L., Citrus reticulata chinase Blanco and Citrus sinensis (L.) Osbeck (Family: Rutaceae) and evaluated against Culex pipiens L.1758 (Family: Culicidae). Chemical composition indicated that the EOs were rich in essential phytochemicals including hydrocarbons, monoterpenes and sesquiterpenes. These constituents revealed some variability among the oils displaying interesting chemotypes limonene (35-51%), 1R-α-pinene (1.04-2...
October 10, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28993279/anti-scorpion-venom-activity-of-thapsia-garganica-methanolic-extract-histopathological-and-biochemical-evidences
#13
Btissam Bouimeja, Moulay Abdelmonaim El Hidan, Oulaid Touloun, Mehdi Ait Laaradia, Loubna Ait Dra, Noureddine El Khoudri, Abderrahman Chait, Ali Boumezzough
ETHNOPHARMACOLOGICAL RELEVANCE: Thapsia garganica, is a herbal medicine traditionally used as diuretic, emetic and purgative. It is also used as anti-scorpion venom in Morocco; however, its protective effects against scorpion venom remain elusive. AIM OF THE STUDY: The present study was undertaken to evaluate anti-venom activity of T. garganica in vivo through histological and biochemical studies. MATERIALS AND METHODS: Methanolic leaves extract of T...
October 6, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28992569/4-alkyliden-azetidinones-modified-with-plant-derived-polyphenols-antibacterial-and-antioxidant-properties
#14
Daria Giacomini, Rosario Musumeci, Paola Galletti, Giulia Martelli, Lorenzo Assennato, Gianni Sacchetti, Alessandra Guerrini, Enrico Calaresu, Marianna Martinelli, Clementina Cocuzza
Antimicrobial resistance is one of the major and growing concerns in hospital- and community acquired infections, and new antimicrobial agents are therefore urgently required. It was reported that oxidative stress could contribute to the selection of resistant bacterial strains, since reactive oxygen species (ROS) revealed to be an essential driving force. In the present work 4-alkylidene-azetidinones, a new class of antibacterial agents, were functionalized with phytochemical polyphenolic acids such as protocatechuic, piperonyl, caffeic, ferulic, or sinapic acids and investigated as dual target antibacterial-antioxidant compounds...
September 23, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28991198/gypmacrophin-a-a-rare-pentacyclic-sesterterpenoid-together-with-three-depsides-functioned-as-new-chemical-evidence-for-gypsoplaca-macrophylla-zahlbr-timdal-identification
#15
Yuan-Fei Zhou, Hai-Xia Shi, Kun Hu, Jian-Wei Tang, Xing-Ren Li, Xue Du, Han-Dong Sun, Li-Song Wang, Jian-Xin Pu
The phytochemical investigation on 1 g of materials from Gypsoplacamacrophylla (Zahlbr.) Timdal resulted in the discovery of gypmacrophin A, a rare pentacyclic sesterterpenoid; brialmontin III, a new polysubstituted depside and two known ones, brialmontins I and II. The structure and absolute configurations of gypmacrophin A were elucidated by spectroscopic analyses and computational methods. Gypmacrophin A showed weak inhibition of AchE with an IC50 value of 32.03 μM. The four compounds provided new chemical evidence for G...
October 9, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28989252/operculina-turpethum-linn-silva-manso-as-a-medicinal-plant-species-a-review-on-bioactive-components-and-pharmacological-properties
#16
REVIEW
Shweta Gupta, Akash Ved
Operculina turpethum (Linn.) (OT) Silva Manso belongs to the family Convolvulaceae. This review incorporates literature for the phytochemical and pharmacological profile of OT herb. Exhaustive literature survey was done using all the details on phytochemistry and pharmacology of OT available. This herb was found to be a potent source of bioactive compounds such as α- and β-turpethein, turpethinic acids (A, B, C, D, and E), coumarins, cycloartenol, lanosta-5-ene, 24-methylene-δ-5-lanosterol, α- and β-rhamnose, β-sitosterol, lupeol, scopoletin, betulin, acrylamide, stigma-5,22dien-3-O-β-D-glucopyranoside, β-sitosterol-β-D-glucoside (H-1), 22,23-dihydro-α-spinosterol-β-D-glucoside (H-2), and salicylic acid (CH-2), which are useful in fevers, edema, ascites, anorexia, constipation, hepatosplenomegaly, hemorrhoids, cervical lymphadenitis, fistulas, constipation, chronic gout, fever, bronchitis, ulcers, hemorrhoids, tumors, obesity, jaundice, herpes, induce lacrimation, and other skin disorders...
July 2017: Pharmacognosy Reviews
https://www.readbyqxmd.com/read/28989251/a-hidden-treasure-the-borneo-mistletoes
#17
REVIEW
Ya Chee Lim, Rajan Rajabalaya, Sheba Rani David
The European mistletoe, Viscum album, is the most common consumed adjuvant among cancer patients in Europe. Its success warrants a report on three most apparent mistletoes found in Borneo Island, namely Scurrula ferruginea, Macrosolen cochinchinensis, and Dendrophthoe curvata. The traditional and pharmacological uses of these mistletoes include antibacterial, anticancer, antiviral, antihypertensive, antioxidative, and cytotoxic effects. Phytochemicals such as flavonols, alkaloids, tannins, and gallic acid have been reported in one of these mistletoes...
July 2017: Pharmacognosy Reviews
https://www.readbyqxmd.com/read/28989244/herbal-drugs-from-sudan-traditional-uses-and-phytoconstituents
#18
REVIEW
Mohamed Gamaleldin Elsadig Karar, Nikolai Kuhnert
Sudan folklore medicine is characterized by a unique combination of Islamic, Arabic, and African cultures. In poor communities, traditional medicine has remained as the most reasonable source of treatment of several diseases and microbial infections. Although the traditional medicine is accepted in Sudan, to date there is no updated review available, which focuses on most effective and frequently used Sudanese medicinal plants. Thus, this review aims to summarize the published information on the ethnobotanical uses of medicinal plants from Sudan, preparation methods, phytochemistry, and ethnopharmacology...
July 2017: Pharmacognosy Reviews
https://www.readbyqxmd.com/read/28988386/perspectives-on-medicinal-properties-of-natural-phenolic-monoterpenoids-and-their-hybrids
#19
REVIEW
Jamatsing D Rajput, Suresh D Bagul, Umesh D Pete, Chetan M Zade, Subhash B Padhye, Ratnamala S Bendre
Carvacrol, thymol and eugenol belong to a class of naturally presenting phenols with a ten-carbon unit, which are present in essential oils of many plants. These versatile molecules are incorporated as useful ingredients in many food products and find applications in agricultural, pharmaceutical, fragrance, cosmetic, flavor and other industries. They are wide ranging of biological and pharmaceutical activities: anti-inflammatory, antimicrobial, analgesic, anticancer and antioxidant. This review summarizes pharmacological and medicinal activities of these phytochemicals and their synthetic hybrids...
October 7, 2017: Molecular Diversity
https://www.readbyqxmd.com/read/28987941/study-of-the-non-clinical-healing-activities-of-the-extract-and-gel-of-portulaca-pilosa-l-in-skin-wounds-in-wistar-rats-a-preliminary-study
#20
Albenise Santana Alves Barros, Helison Oliveira Carvalho, Igor Victor Ferreira Dos Santos, Talisson Taglialegna, Tafnis Ingret Dos Santos Sampaio, Jonatas Lobato Duarte, Caio Pinho Fernandes, José Carlos Tavares Carvalho
INTRODUCTION: Portulaca pilosa L., belonging to the family Portulacaceae, is a common herbaceous plant in the Americas and in the Amazon, is popularly known as love-grown and is traditionally used as an aid in the treatment of burns, buds, insect bites and wound healing. This study aims to evaluate the non-clinical topical healing activity of the P. pilosa gel (GPP) and the propyleneglycol extract of P. pilosa (EPP) in Wistar rats. METHODS: For the healing activity, wistar rats were divided into the following groups: negative control (GVE - vehicle, 150mg/kg), positive control (Fibrinase(®)- FIB, 100U/kg), Portulaca pilosa gel 10%, (GPP, 150mg/kg), and propylenglycollic extract of Portulaca pilosa (EPP, 150 mg/kg), which were submitted to a surgical procedure to obtain the wounds, and were treated topically for 7days...
October 4, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
keyword
keyword
21609
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"