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Phytochemicals

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https://www.readbyqxmd.com/read/29667820/identification-of-ingol-and-rhamnofolane-diterpenoids-from-euphorbia-resinifera-and-their-abilities-to-induce-lysosomal-biosynthesis
#1
Ning-Dong Zhao, Xiao Ding, Yu Song, Dong-Qiong Yang, Hai-Li Yu, Tiwalade Adegoke Adelakun, Wen-Dan Qian, Yu Zhang, Ying-Tong Di, Fang Gao, Xiao-Jiang Hao, Shun-Lin Li
The phytochemical study of Euphorbia resinifera afforded 18 structurally diverse diterpenoids, including 14 new ingol-type diterpenoids, euphorblins A-N (1-14), a new rhamnofolane diterpenoid, euphorblin O (15), and three known analogues (16-18). The structures of these compounds were deduced using 2D NMR spectroscopy and NOE experiments. The structure of compound 1 was confirmed by single-crystal X-ray crystallography. The abilities of the compounds to enhance lysosomal biosynthesis were evaluated through LysoTracker Red staining...
April 18, 2018: Journal of Natural Products
https://www.readbyqxmd.com/read/29667419/furanocoumarins-with-potential-antiproliferative-activities-from-clausena-lenis
#2
Yan-Ping Liu, Qing Wen, Shi Hu, Yan-Lei Ma, Zhi-Hua Jiang, Jin-Ying Tang, Yan-Hui Fu, Shen-Xiang Qiu
A phytochemical investigation on the stems and leaves of Clausena lenis led to the isolation of a new furanocoumarin, clauselenisin A (1), together with five known analogues (2-6). The structure of 1 was elucidated by extensive spectroscopic methods and the known compounds were identified by comparisons with data reported in the literature. All known compounds (2-6) were isolated from C. lenis for the first time. All isolated compounds were evaluated for their their antiproliferative activities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 in vitro...
April 18, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29666580/chemical-composition-of-scrophularia-lucida-and-the-effects-on-tumor-invasiveness-in-vitro
#3
Verena Lewenhofer, Lisa Schweighofer, Tobias Ledermüller, Julia Eichsteininger, Hanspeter Kählig, Martin Zehl, Chi H Nguyen, Georg Krupitza, Ali Özmen, Liselotte Krenn
A detannified methanolic extract of Scrophularia lucida L. attenuated the formation of cancer cell-induced circular chemorepellent induced defects (CCIDs) in the lymph endothelial cell barrier, which resemble entry ports for the intravasating tumor into the vasculature as a prerequisite for lymph node metastasis. Therefore, the composition of this extract was studied in an activity-guided approach. Since no data on the secondary metabolites of this plant were available, first phytochemical data were collected in the course of the fractionation of the extract...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29664082/unsaponifiable-fraction-isolated-from-grape-vitis-vinifera-l-seed-oil-attenuates-oxidative-and-inflammatory-responses-in-human-primary-monocytes
#4
Maria C Millan-Linares, Beatriz Bermudez, Maria E Martin, Ernesto Muñoz, Rocio Abia, Francisco Millan, Francisco J G Muriana, Sergio Montserrat-de la Paz
Grape (Vitis vinifera L.) seed has well-known potential for production of oil as a byproduct of winemaking and is a rich source of bioactive compounds. Herein, we report that the unsaponifiable fraction (UF) isolated from grape seed oil (GSO) possesses anti-oxidative and anti-inflammatory properties towards human primary monocytes. The UF isolated from GSO was phytochemically characterized by GC-MS and HPLC. Freshly obtained human monocytes were used to analyse the effects of GSOUF (10-100 μg mL-1) on oxidative and inflammatory responses using FACS analysis, RT-qPCR, and ELISA procedures...
April 17, 2018: Food & Function
https://www.readbyqxmd.com/read/29663896/molecular-interaction-and-computational-analytical-studies-of-pinocembrin-for-its-antiangiogenic-potential-targeting-vegfr-2-a-persuader-of-metastasis
#5
Neha Sharma, Mala Sharma, Eram Shakeel, Qazi M Sajid Jamal, Mohammad A Kamal, Usman Sayeed, Mohammad K A Khan, Mohammad H Siddiqui, Jamal M Arif, Salman Akhtar
BACKGROUND: Designing a novel antagonist against VEGFR-2 is being applied currently to inhibit cancer growth and metastasis. Because of the unexpected side effects incurred by the contemporary anticancer medications, the focus has been laid towards identifying natural compounds that might carry the potential to inhibit tumor progression. VEGR-2 remains an important target for anticancer drug development as it is the master regulator of vascular growth. OBJECTIVE: The study focuses on virtual screening of compounds from plants of Asteraceae family that bears antiangiogenic potential and thus, inhibiting VEGFR-2 using a computational approach...
April 16, 2018: Medicinal Chemistry
https://www.readbyqxmd.com/read/29663876/phytochemical-screening-antiproliferative-and-antioxidant-properties-of-various-extracts-from-endemic-origanum-acutidens
#6
Feyza Oke-Altuntas, Mehmet Ali Demirci, Ibrahim Demirtas, Ayse Sahin Yaglioglu, Lutfi Behcet
AIM AND OBJECTIVE: Origanum acutidens (Hand.-Mazz.) Ietsw. is an endemic and perennial plant grown mainly in East Anatolia. Recently, natural plant products have attracted interest due to their safety and therapeutic effects. Therefore, the aim of this study was to investigate phytochemical contents and biological effects of Origanum acutidens. MATERIALS AND METHODS: The aerial parts of O. acutidens were extracted with water, ethyl acetate, n-butanol, and methanol/chloroform solvents...
April 16, 2018: Combinatorial Chemistry & High Throughput Screening
https://www.readbyqxmd.com/read/29663826/antioxidant-and-hepato-preventive-effect-of-citrus-aurantium-extract-against-carbon-tetrachloride-induced-hepatotoxicity-in-rats-and-characterisation-of-its-bioactive-compounds-by-hplc-ms
#7
Anis Ben Hsouna, Manel Gargouri, Wissal Dhifi, Walid Saibi
The objective of this study is to explore the preventive effects of ethyl acetate fraction from Citrus aurantium leaf extract (EACA), associated with its phytochemical content, against the toxic impacts of acute exposure to carbon tetrachloride (CCl4 ) in the liver of adult rats. HPLC analysis of ethyl acetate fraction from extract C. aurantium revealed eight compounds. Administration of a single dose of CCl4 caused hepatoxicity as monitored by an increase in lipid peroxidation (thiobarbituric acid reactive substances) and in protein carbonyl level but a decrease in antioxidant markers in the liver tissue...
April 17, 2018: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29660809/prosopis-nigra-mesocarp-fine-flour-a-source-of-phytochemicals-with-potential-effect-on-enzymes-linked-to-metabolic-syndrome-oxidative-stress-and-inflammatory-process
#8
María J Pérez, Iris C Zampini, Maria R Alberto, María I Isla
This work is part of the search in native food matrices from arid regions of Argentina of interest to improve human health. Prosopis species are ethnic food resources in South America capable of growing in arid and semi-arid environments. This work was focused to determine the nutritional and phytochemical composition of Prosopis nigra fine flour and to evaluate its biological properties. Flour showed a high level of sucrose (30.35 g/100 g flour), fiber (6.34 g/100 g flour), polyphenols (0.45 g GAE/100 g flour), and minerals (potassium, calcium, and magnesium)...
April 16, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29660650/evidence-for-gastroprotective-anti-inflammatory-and-antioxidant-potential-of-methanolic-extract-of-cordia-dichotoma-leaves-on-indomethacin-and-stress-induced-gastric-lesions-in-wistar-rats
#9
Ketan Vinayakrao Hatware, Sanjay Sharma, Kiran Patil, Meghanath Shete, Sravani Karri, Gaurav Gupta
The Cordia dichotoma (CD) is having anticancer and other pharmacological effects as it contains mainly flavonoids. The present study was aimed to demonstrate the gastroprotective effect of methanolic extract of CD leaves (MECD) obtained using Soxhlet extractor. In this study the qualitative phytochemical analysis of MECD revealed the presence of bioflavonoids and determination of quercetin was confirmed by HPLC analysis. The MECD was administered orally at doses 50 mg/kg, 100 mg/kg and 200 mg/kg against indomethacin induced gastric ulceration and stress-induced gastric ulceration in Wistar rats...
April 13, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29660588/chemically-synthesized-butein-and-butin-optical-structure-and-electrochemical-redox-functionality-at-electrode-interface
#10
Priya Darshani, Manju Bhargavi Gumpu, Prasanth Thumpati, John Bosco Balaguru Rayappan, Velayutham Ravichandiran, Gururaja Perumal Pazhani, Murugan Veerapandian
Progress in the development of phytochemistry has delivered advancement in materials functionality for range of inter/trans-disciplinary application. Here, we investigated the structural functionality of chemically synthesized phytoconstitutent, chalcone (butein) and flavanone (butin). Photoactive and electroactive behavior of butein and butin were comprehensively studied using UV-vis absorbance, photoluminescence and cyclic voltammetric techniques. Surface morphology of the butein and butin powders was characterized from scanning electron microscope at an operating voltage of 10 kV...
April 6, 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29658332/structurally-diverse-diterpenoids-from-trigonostemon-howii
#11
Yan-Ping Liu, Qing Wen, Shi Hu, Yan-Lei Ma, Zhi-Hua Jiang, Jin-Ying Tang, Yan-Hui Fu
Phytochemical investigation on the stems and leaves of Trigonostemon howii resulted in the isolation of a new abietane diterpenoid, trigohowimine A (1), along with seven known structurally diverse diterpenoids (2-8). The structure of 1 was elucidated by extensive spectroscopic methods and the known compounds were identified by comparison with data reported in the literature. New compound 1 was evaluated for its cytotoxicities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480. Compound 1 showed significant inhibitory effects against various human cancer cell lines with IC50 values ranging from 0...
April 16, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29657503/phytochemical-constituents-and-antimicrobial-activity-of-the-ethanol-and-chloroform-crude-leaf-extracts-of-spathiphyllum-cannifolium-dryand-ex-sims-schott
#12
Arunachalam Dhayalan, Daniel E Gracilla, Renato A Dela Peña, Marilyn T Malison, Christian R Pangilinan
Context: The study investigated the medicinal properties of Spathiphyllum cannifolium (Dryand. ex Sims) Schott as a possible source of antimicrobial compounds. Materials and Methods: The phytochemical constituents were screened using qualitative methods and the antibacterial and antifungal activities were determined using agar well diffusion method. Statistical Analysis: One-way analysis of variance and Fisher's least significant difference test were used...
January 2018: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/29656657/phytochemical-profile-and-biological-activities-of-deverra-tortuosa-desf-dc-a-desert-aromatic-shrub-widespread-in-northern-region-of-saudi-arabia
#13
Arbi Guetat, Abdennacer Boulila, Mohamed Boussaid
The present study describes the chemical composition of the essential oil of different plant parts of Devrra tortuosa; in vivo and in vitro biological activities of plant extract and essential oils. Apiol was found to be the major component of the oil (between 65.73% and 74.41%). The best antioxidant activities were observed for the oil of flowers (IC50 = 175 μg/ml). The samples of stems and roots exhibit lower antioxidant activity (IC50 = 201 μg/ml and 182 μg/ml, respectively). The values of IC50 showed that the extracts of methanol exhibit the highest antioxidants activities (IC50 = 64...
April 16, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29656381/cowpea-an-overview-on-its-nutritional-facts-and-health-benefits
#14
REVIEW
Chathuni Jayathilake, Rizliya Visvanathan, Afka Deen, Ruksheela Bangamuwage, Barana C Jayawardana, Srinivas Nammi, Ruvini Liyanage
Cowpea (Vigna unguiculata) is a legume consumed as a high-quality plant protein source in many parts of the world. High protein and carbohydrate contents with relatively low fat content and complementary amino acid pattern to that of cereal grains make cowpea an important nutritional food in the human diet. Cowpea has gained more attention recently from consumers and researchers worldwide due to its exerted health beneficial properties including anti-diabetic, anti-cancer, anti-hyperlipidemic, anti-inflammatory and anti-hypertensive properties...
April 15, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29655760/psidium-cattleianum-fruits-a-review-on-its-composition-and-bioactivity
#15
REVIEW
Elisa Dos Santos Pereira, Juliana Vinholes, Rodrigo C Franzon, Gabriel Dalmazo, Márcia Vizzotto, Leonardo Nora
Psidium cattleianum Sabine, commonly known as araçá, is a Brazilian native fruit, which is very juicy, with sweet to sub acid pulp and a spicy touch. The fruit can be eaten fresh or processed into juice, jellies and ice creams. Araçás are source of vitamin C, minerals, fatty acids, polysaccharides, volatile compounds, carotenoids and phenolic compounds, which can provide nutrients and phytochemical agents with different biological functions. Different pharmacological studies demonstrate that P. cattleianum exerts antioxidant, antidiabetic, anticarcinogenic, antimicrobial, anti-inflammatory and antiaging effects...
August 30, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29651878/in-vivo-hypoglycemic-effect-of-kigelia-africana-lam-studies-with-alloxan-induced-diabetic-mice
#16
Stephen M Njogu, Wycliffe M Arika, Alex K Machocho, Joseph J N Ngeranwa, Eliud N M Njagi
The claims by the traditional herbal medicine practitioners that Kigelia africana has bioactivity against several diseases, including diabetes mellitus, were investigated in this study. Type I diabetes mellitus was induced in mice by intraperitoneal administration of alloxan monohydrate followed by treatment with the therapeutic doses of the aqueous and ethyl acetate leaf extract of K africana to the experimentally diabetic mice. The treatment effects were compared with the normal control, diabetic control, and diabetic control rats treated with a standard antidiabetic drugs (insulin administered intraperitoneally at 1 IU/kg body weight in 0...
January 2018: Journal of evidence-based integrative medicine
https://www.readbyqxmd.com/read/29649863/new-taste-active-3-o-%C3%AE-d-glucosyl-2-oxoindole-3-acetic-acids-and-diarylheptanoids-in-cimiciato-infected-hazelnuts
#17
Barbara Singldinger, Andreas Dunkel, Dominic Bahmann, Claudia Bahmann, Daniel Kadow, Bernward Bisping, Thomas Hofmann
Activity-guided fractionation in combination with sensory analytics, LC-TOF-MS, and 1D/2D-NMR spectroscopy enabled the identification of the bitter tasting diarylheptanoids asadanin, giffonin P and the previously not reported (E)-7,9,10,13-tetrahydroxy-1,7-bis(2-hydroxyphenyl)hept-9-en-11-one and 4,12,16-trihydroxy-2-oxatricyclo[13.3.1.13,7]-nonadeca-1(18),3,5,7(20),8,15,17-heptaen as well as the yet unknown astringent compounds 2-(3-hydroxy-2-oxoindolin-3-yl) acetic acid 3-O-6´-galactopyranosyl-2"-(2"oxoindolin-3"yl) acetate and 3-(O-β-D-glycosyl) dioxindole-3-acetic acid in Cimiciato-infected hazelnuts exhibiting a bitter off-taste...
April 12, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29649320/strychnos-pseudoquina-modulates-the-morphological-reorganization-of-the-scar-tissue-of-second-intention-cutaneous-wounds-in-rats
#18
Mariáurea Matias Sarandy, Lyvia Lopes Miranda, Luciana Schulthais Altoé, Rômulo Dias Novaes, Virgínia Vinha Zanuncio, João Paulo Viana Leite, Reggiani Vilela Gonçalves
Natural substances are used in folk medicines to treat injuries. Strychnos pseudoquina has scarring, antipyretic, and antimalarial actions. The present study aimed to analyze the effect of S. pseudoquina on cutaneous wound healing in rats. The S. pseudoquina extract was submitted to phytochemical prospection. The levels of flavonoids and total phenolic compounds in the extract were 50.7 mg/g and 2.59 mg/g, respectively. Thirty Wistar rats were individualized in cages with food and water ad libitum (registration no...
2018: PloS One
https://www.readbyqxmd.com/read/29649123/phytochemical-properties-and-nutrigenomic-implications-of-yacon-as-a-potential-source-of-prebiotic-current-evidence-and-future-directions
#19
REVIEW
Yang Cao, Zheng Feei Ma, Hongxia Zhang, Yifan Jin, Yihe Zhang, Frank Hayford
The human gut is densely populated with diverse microbial communities that are essential to health. Prebiotics and fiber have been shown to possess the ability to modulate the gut microbiota. One of the plants being considered as a potential source of prebiotic is yacon. Yacon is an underutilized plant consumed as a traditional root-based fruit in South America. Yacon mainly contains fructooligosaccharides (FOS) and inulin. Therefore, it has bifidogenic benefits for gut health, because FOS are not easily broken down by digestive enzymes...
April 12, 2018: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/29642672/phytochemicals-and-antioxidant-capacity-from-some-tropical-edible-plants
#20
Heeok Hong, Jun-Hyeong Lee, Soo-Ki Kim
Objective: To find biological functions such as antibacterial and antioxidant activities in several tropical plants and to investigate the possibility of antibiotic substitute agents to prevent and treat diseases caused by pathogenic bacteria. Methods: Those plants such as Poncirus trifoliata fruit (Makrut), Zingiber officinale Rosc (Khing), Areca catechu L. (Mak), Solanum melongena L. I (Makkhuayao), and Solanum melongena L. II (Makhurapro) were extracted by methanol, n-hexane, chloroform, ethyl acetate, butanol and water...
April 12, 2018: Asian-Australasian Journal of Animal Sciences
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