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https://www.readbyqxmd.com/read/28932125/an-empirically-generated-responder-definition-for-rosacea-treatment
#1
Gerald Staedtler, Kaweh Shakery, Jan Endrikat, Richard Nkulikiyinka, Christoph Gerlinger
OBJECTIVE: The aim of this study was to empirically generate a responder definition for the treatment of papulopustular rosacea. METHODS: A total of 8 multicenter clinical studies on patients with papulopustular facial rosacea were analyzed. All patients were treated with azelaic acid and/or comparator treatments. The severity of rosacea was described by the Investigator Global Assessment (IGA) and the number of lesions. Patients with the IGA score of "clear/minimal" were considered as responders, and those staying in the range of IGA "mild to severe" as nonresponders...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28924515/characterization-of-microsatellite-markers-for-broussonetia-papyrifera-moraceae
#2
Johany Peñailillo, Wenhsi Kuo, Gabriela Olivares, Gerardo Silva-Poblete, Barbara Peña-Ahumada, Sofía Muñoz, Ximena Moncada, Kuo-Fang Chung, Daniela Seelenfreund, Andrea Seelenfreund
PREMISE OF THE STUDY: Broussonetia papyrifera (Moraceae) is native to Asia and is used as a medicinal plant and as a source of fiber for making paper. It was dispersed into the Pacific region as a fiber source for making nonwoven textiles (barkcloth). Microsatellites were developed to trace the human-mediated dispersal of this species into the Pacific region. METHODS AND RESULTS: A set of 36 microsatellites was isolated and initially assayed on 10 accessions to assess polymorphism...
August 2017: Applications in Plant Sciences
https://www.readbyqxmd.com/read/28920449/the-relationship-between-migraine-and-rosacea-systematic-review-and-meta-analysis
#3
Casper Emil Christensen, Frederikke Schelde Andersen, Nita Wienholtz, Alexander Egeberg, Jacob P Thyssen, Messoud Ashina
Objective To systematically review the association between migraine and rosacea. Background Migraine is a complex disorder with episodes of headache, nausea, photo- and phonophobia. Rosacea is an inflammatory skin condition with flushing, erythema, telangiectasia, papules, and pustules. Both are chronic disorders with exacerbations of symptoms almost exclusively in areas innervated by the trigeminal nerve. Previous studies found an association between these disorders. We review these findings, provide a meta-analysis, and discuss possible pathophysiological commonalities...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28917186/compounds-isolated-from-eriobotrya-deflexa-leaves-protect-against-ultraviolet-radiation-b-induced-photoaging-in-human-fibroblasts
#4
Chung-Yu Huang, Yi-Tzu Lin, Hsiang-Chun Kuo, Wen-Fei Chiou, Mei-Hsien Lee
Ultraviolet (UV) irradiation leads to skin photoaging because of the upregulation of matrix metalloproteinase (MMP)-1 and downregulation of type I collagen and tissue inhibitor of metalloproteinase (TIMP)-1. Eriobotrya deflexa (Hemsl.) Nakai (Rosaceae) is a flowering plant endemic to Taiwan, and its leaves have been used as an expectorant and in antitussive folk remedy. Our previous studies have demonstrated that an E. deflexa leaf extract functions as a free radical scavenger. The current evaluated the antiphotoaging effect of partitioned fractions and specific compounds from the leaves of E...
September 4, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28915286/treatment-of-rosacea-with-concomitant-use-of-topical-ivermectin-1-cream-and-brimonidine-0-33-gel-a-randomized-vehicle-controlled-study
#5
Linda Stein Gold, Kim Papp, Charles Lynde, Edward Lain, Melinda Gooderham, Sandra Johnson, Nabil Kerrouche
BACKGROUND: There is currently a lack of data on the simultaneous treatment of different features of rosacea. Individually, ivermectin 1% (IVM) cream and brimonidine 0.33% (BR) gel have demonstrated efficacy on inflammatory lesions and persistent erythema, respectively. OBJECTIVE: To evaluate the efficacy, safety, patient satisfaction, and optimal timing of administration of IVM associated with BR (IVM+BR) versus their vehicles in rosacea (investigator global assessment [IGA] ≥3)...
September 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28902946/the-association-between-low-grade-systemic-inflammation-and-skin-diseases-a-cross-sectional-survey-in-the-northern-finland-birth-cohort-1966
#6
Suvi-Päivikki Sinikumpu, Laura Huilaja, Juha Auvinen, Jari Jokelainen, Katri Puukka, Aimo Ruokonen, Markku Timonen, Kaisa Tasanen
Low grade inflammation is associated with many noncommunicable diseases. The association between skin diseases in general and systemic inflammation has not previously been studied at the population level. A whole-body investigation on 1,930 adults belonging to Northern Finland Birth Cohort 1966 was performed and high sensitive C-reactive protein (CRP) level was measured as a marker of low grade inflammation in order to determine the association between low grade inflammation and skin diseases in an unselected adult population...
September 13, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28902026/chemical-peels-indications-and-special-considerations-for-the-male-patient
#7
Jeave Reserva, Amanda Champlain, Seaver L Soon, Rebecca Tung
BACKGROUND: Chemical peels are a mainstay of aesthetic medicine and an increasingly popular cosmetic procedure performed in men. OBJECTIVE: To review the indications for chemical peels with an emphasis on performing this procedure in male patients. MATERIALS AND METHODS: Review of the English PubMed/MEDLINE literature and specialty texts in cosmetic dermatology, oculoplastic, and facial aesthetic surgery regarding sex-specific use of chemical peels in men...
September 4, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28898474/quality-of-life-measurement-in-acne-position-paper-of-the-european-academy-of-dermatology-and-venereology-eadv-task-forces-on-quality-of-life-and-patient-oriented-outcomes-qol-and-po-and-acne-rosacea-and-hidradenitis-suppurativa-arhs
#8
REVIEW
P V Chernyshov, C C Zouboulis, L Tomas-Aragones, G B Jemec, L Manolache, T Tzellos, F Sampogna, A W M Evers, C Dessinioti, S E Marron, V Bettoli, O D van Cranenburgh, A Svensson, A I Liakou, F Poot, J C Szepietowski, Salek, A Y Finlay
Acne causes profound negative psychological and social effects on the quality of life (QoL) of patients. The European Dermatology Forum S3-Guideline for the Treatment of Acne recommended adopting a QoL measure as an integral part of acne management. Because of constantly growing interest in health-related QoL assessment in acne and because of the high impact of acne on patients' lives, the European Academy of Dermatology and Venereology Task Force on QoL and Patient Oriented Outcomes and the Task Force on Acne, Rosacea and Hidradenitis Suppurativa have documented the QoL instruments that have been used in acne patients, with information on validation, purposes of their usage, description of common limitations and mistakes in their usage and overall recommendations...
September 12, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28895387/chaenomeles-%C3%A2-health-promoting-benefits
#9
Katarzyna Watychowicz, Katarzyna Janda, Karolina Jakubczyk, Jolanta Wolska
Chaenomeles is a genus of deciduous spiny in the family of Rosaceae (Pomoideae subfamily). For centuries, the plant was used for a treatment of anemia, rheumatism, gout and cardiovascular diseases. The chemical composition studies of Chaenomeles showed the presence of many biologically active compounds, such as: phenolic compounds, organic acids, terpenoids, alcohols, ketones or aldehydes. Fruit of Chaenomeles has the largest applying potential due to extensive use of medicinal and high concentration of vitamin C...
2017: Roczniki Państwowego Zakładu Higieny
https://www.readbyqxmd.com/read/28889348/treatment-of-erythemato-telangiectatic-rosacea-with-brimonidine-alone-or-combined-with-vascular-laser-based-on-preliminary-instrumental-evaluation-of-the-vascular-component
#10
Giuseppe Micali, Federica Dall'Oglio, Anna Elisa Verzì, Ivano Luppino, Karishma Bhatt, Francesco Lacarrubba
The purpose of this study is to evaluate the outcome of a series of patients with erythematotelangiectatic rosacea (ETR) affected by persistent erythema and varying degree of telangiectasias being treated with brimonidine alone or combined with a vascular laser based on the type of vascular components preliminarily evaluated by clinical and instrumental observation. Ten patients affected by ETR were enrolled in a pilot, open study. Instrumental evaluation included erythema-directed digital photography by VISIA-CR™ system and X10 dermoscopy...
September 9, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28888216/vitamin-b-derivative-nicotinamide-appears-to-reduce-skin-cancer-risk
#11
S Nazarali, P Kuzel
Nicotinamide, an amide form of vitamin B3, has shown the potential to treat a variety of dermatological conditions, including acne, rosacea, and atopic dermatitis. Recent studies have demonstrated the role of nicotinamide, in both topical and oral forms, as a chemopreventive agent against skin cancer. Its anti-carcinogenic role may be due to its ability to enhance DNA repair and prevent ultraviolet (UV)-induced immunosuppression, which is known to contribute to the progression of pre-malignant lesions. Furthermore, nicotinamide is a precursor of essential coenzymes for many important reactions in the body, including the production of nicotinamide adenine dinucleotide (NAD)...
September 2017: Skin Therapy Letter
https://www.readbyqxmd.com/read/28886453/patterns-of-low-temperature-induced-accumulation-of-dehydrins-in-rosaceae-crops-evidence-for-post-translational-modification-in-apple
#12
Perttu Haimi, Jurgita Vinskienė, Inga Stepulaitienė, Danas Baniulis, Gražina Stanienė, Jūratė Bronė Šikšnianienė, Rytis Rugienius
Important crop plants of Rosaceae family are often damaged during winter due to the lack of acclimation and cold hardiness. One of the cellular responses of plants to cold stress is the accumulation of dehydrin proteins. We studied the expression of dehydrins in several Rosaceae species during low temperature treatment in vitro. Microshoots of Pyrus communis, Malus×domestica, Fragaria vesca, Fragaria×ananassa, Prunus cerasus and Prunus avium cultivars were grown in low temperature conditions. Genotype -specific accumulation of dehydrins was detected by immunoblot analysis of the extracted proteins...
August 31, 2017: Journal of Plant Physiology
https://www.readbyqxmd.com/read/28884663/proposal-of-candidatus-frankia-californiensis-the-uncultured-symbiont-in-nitrogen-fixing-root-nodules-of-a-phylogenetically-broad-group-of-hosts-endemic-to-western-north-america
#13
Philippe Normand, Thanh Van Nguyen, Kai Battenberg, Alison M Berry, Brian Vanden Heuvel, Maria P Fernandez, Katharina Pawlowski
The genus Frankia comprises a group of nitrogen-fixing actinobacteria that form root-nodule symbioses with perennial dicotyledonous plants in the nitrogen-fixing clade. These bacteria have been characterized phylogenetically and grouped into four clusters (clusters 1-4). Cluster 2 contains mostly uncultured strains that induce nodules on species of the genera Datisca (Datiscaceae), Coriaria (Coriariaceae), Ceanothus (Rhamnaceae) and several genera in the family Rosaceae (Cercocarpus, Chamaebatia, Dryas, Purshia), all of which except members of the genus Coriaria are present within the California Floristic Province (CFP) or neighbouring areas of western North America...
September 8, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28874202/ethnobotanical-survey-of-wild-food-plants-traditionally-collected-and-consumed-in-the-middle-agri-valley-basilicata-region-southern-italy
#14
Sabrina Sansanelli, Maura Ferri, Mirko Salinitro, Annalisa Tassoni
BACKGROUND: This research was carried out in a scarcely populated area of the Middle Agri Valley (Basilicata region, southern Italy). The aim of the study was to record local knowledge on the traditional uses of wild food plants, as well as to collect information regarding the practices (gathering, processing and cooking) and the medicinal uses related to these plants. METHODS: Fifty-eight people still possessing traditional local knowledge (TLK), 74% women and 26% men, were interviewed between May-August 2012 and January 2013, using open and semi-structured ethnobotanical interviews...
September 6, 2017: Journal of Ethnobiology and Ethnomedicine
https://www.readbyqxmd.com/read/28873109/lack-of-significant-anti-inflammatory-activity-with-clindamycin-in-the-treatment-of-rosacea-results-of-2-randomized-vehicle-controlled-trials
#15
Philippe Martel, Michael Jarratt, Jonathan Weiss, Isabelle Carlavan
Rosacea is a chronic inflammatory skin disease of the face. The objective of the studies described here was to evaluate the efficacy of clindamycin in the treatment of rosacea. Two multicenter, randomized, vehicle-controlled, phase 2 studies were conducted in participants with moderate to severe rosacea. Study A was a 12-week dose-comparison, 5-arm, parallel group comparison of clindamycin cream 1% or vehicle once or twice daily and clindamycin cream 0.3% once daily. Study B was a 2-arm comparison of twice daily clindamycin gel 1% versus vehicle gel...
July 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/28873101/rosacea-treatment-schema-an-update
#16
Lorraine L Rosamilia
No abstract text is available yet for this article.
July 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/28871930/can-hematologic-parameters-be-an-indicator-of-metabolic-disorders-accompanying-rosacea
#17
Asli Akin Belli, Asude Kara, Seyran Ozbas Gok
Recently, diverse hematologic parameters have been used as an indicator of the presence or severity of inflammatory and cardiovascular diseases. Our aim was to investigate the ratios of neutrophils to lymphocytes (NL), monocytes to high-density lipoprotein (HDL) cholesterol (MHC), and platelets to lymphocytes (PL) in patients with rosacea in comparison with the control group and determine whether there was a correlation between these ratios and metabolic disorders in patients with rosacea. We conducted a case-control study on 61 patients with rosacea and 60 healthy controls between January 2015 and January 2016 at the Dermatology Outpatient Clinic, Mugla, Turkey...
July 2017: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/28859742/diffuse-papular-eruption-of-the-face-and-eyelids
#18
Stephanie Frisch, Jessica Kozel, Sarah Jensen, Claudia I Vidal
A 68-year-old Caucasian woman presented with a 1-month history of a facial and neck eruption (Figure 1A). Her face was covered with 3-mm monomorphic, pink, shiny, papules and rare pustules on an erythematous background. The eruption extended down the neck, her conjunctivae were injected, and her lid margins were inflamed. She had no history of rosacea.
2017: Skinmed
https://www.readbyqxmd.com/read/28855974/the-skin-microbiome-impact-of-modern-environments-on-skin-ecology-barrier-integrity-and-systemic-immune-programming
#19
REVIEW
Susan L Prescott, Danica-Lea Larcombe, Alan C Logan, Christina West, Wesley Burks, Luis Caraballo, Michael Levin, Eddie Van Etten, Pierre Horwitz, Anita Kozyrskyj, Dianne E Campbell
Skin barrier structure and function is essential to human health. Hitherto unrecognized functions of epidermal keratinocytes show that the skin plays an important role in adapting whole-body physiology to changing environments, including the capacity to produce a wide variety of hormones, neurotransmitters and cytokine that can potentially influence whole-body states, and quite possibly, even emotions. Skin microbiota play an integral role in the maturation and homeostatic regulation of keratinocytes and host immune networks with systemic implications...
2017: World Allergy Organization Journal
https://www.readbyqxmd.com/read/28854285/population-genetic-analysis-of-a-global-collection-of-fragaria-vesca-using-microsatellite-markers
#20
Hrannar Smári Hilmarsson, Timo Hytönen, Sachiko Isobe, Magnus Göransson, Tuomas Toivainen, Jón Hallsteinn Hallsson
The woodland strawberry, Fragaria vesca, holds great promise as a model organism. It not only represents the important Rosaceae family that includes economically important species such as apples, pears, peaches and roses, but it also complements the well-known model organism Arabidopsis thaliana in key areas such as perennial life cycle and the development of fleshy fruit. Analysis of wild populations of A. thaliana has shed light on several important developmental pathways controlling, for example, flowering time and plant growth, suggesting that a similar approach using F...
2017: PloS One
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