Nicholas W Bateman, Tamara Abulez, Christopher M Tarney, Maria V Bariani, Jordan A Driscoll, Anthony R Soltis, Ming Zhou, Brian L Hood, Tracy Litzi, Kelly A Conrads, Amanda Jackson, Julie Oliver, Satishkumar Ranganathan Ganakammal, Frank Schneider, Clifton L Dalgard, Matthew D Wilkerson, Barbara Smith, Victor Borda, Timothy O'Connor, James Segars, S Abbas Shobeiri, Neil T Phippen, Kathleen M Darcy, Ayman Al-Hendy, Thomas P Conrads, George Larry Maxwell
BACKGROUND: Black women are at an increased risk to develop uterine leiomyomas (ULMs) and to experience worse disease prognosis compared to White women. Epidemiological and molecular factors have been identified as underlying these disparities, but there remains a paucity of deep, multi-omic analysis investigating molecular differences in ULMs from Black and White patients. OBJECTIVE: To identify molecular alterations within ULM tissues correlating with patient race by multi-omic analyses of ULMs collected from cohorts of Black and White women...
May 7, 2024: American Journal of Obstetrics and Gynecology