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https://www.readbyqxmd.com/read/28093878/in-pursuit-of-greater-reproducibility-and-credibility-of-early-clinical-biomarker-research
#1
Lisa M McShane
Biomarkers underlie many clinical tests that are integral to the practice of personalized medicine. Reproducibility and scientific credibility of clinical biomarker early development studies are critical to avoid advancing worthless or potentially harmful biomarker-based tests into late phase clinical studies and clinical practice. This commentary discusses key aspects to consider when conducting and evaluating early clinical biomarker research. Greater attention to these aspects would enhance research reproducibility and better prioritize biomarkers for further clinical development...
January 16, 2017: Clinical and Translational Science
https://www.readbyqxmd.com/read/28063875/clinical-worthlessness-of-genetic-prediction-of-common-forms-of-diabetes-mellitus-and-related-chronic-complications-a-position-statement-of-the-italian-society-of-diabetology
#2
REVIEW
R Buzzetti, S Prudente, M Copetti, M Dauriz, S Zampetti, M Garofolo, G Penno, V Trischitta
AIM: We are currently facing several attempts aimed at marketing genetic data for predicting multifactorial diseases, among which diabetes mellitus is one of the more prevalent. The present document primarily aims at providing to practicing physicians a summary of available data regarding the role of genetic information in predicting diabetes and its chronic complications. DATA SYNTHESIS: Firstly, general information about characteristics and performance of risk prediction tools will be presented in order to help clinicians to get acquainted with basic methodological information related to the subject at issue...
August 26, 2016: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/28006716/biomolecular-aspects-of-depression-a-retrospective-analysis
#3
Brandon N Peacock, David J Scheiderer, Gottfried H Kellermann
OBJECTIVE: The effects of psychological stress, oxidative stress, and chronic low grade inflammation on the neuro-immune connection have been implicated in the pathogenesis of depression. Thus, in the recent past, there has been a growing effort in determining the mechanism of this pathogenesis. While attempting to map out, this mechanism researchers and clinicians have searched for clinically relevant biomarkers for use in the diagnosis and for the assessment of those suffering from depression...
November 10, 2016: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/27933018/a-study-of-the-coupling-of-fet-temperament-traits-with-major-depression
#4
Irina N Trofimova, William Sulis
Objective: Temperament and mental illness have been linked to the same systems of behavioral regulation. A temperament model, carefully structured to respond to subtle differences within systems of behavior regulation, should exhibit distinct temperament patterns in the presence of mental illness. Previous comparisons of temperament profiles in mental disorders used mostly emotionality-related traits. In contrast, the Functional Ensemble of Temperament (FET) model differentiates not only between emotionality traits, but also between traits related to physical, verbal, and mental aspects of behavior and maps 12 functional aspects of behavior to temperament traits as well as to symptoms of mental illnesses...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27894466/relationships-between-adult-emotional-states-and-indicators-of-health-care-utilization-findings-from-the-national-health-interview-survey-2006-2014
#5
Judith D Weissman, David Russell, Jeannette Beasley, Melanie Jay, Dolores Malaspina
OBJECTIVE: Adults with serious psychological distress have a high likelihood of mental health problems severe enough to cause serious impairment in social and occupational functioning requiring treatment. These adults visit doctors frequently yet have poor health compared to adults without serious psychological distress. This study examined associations between emotional states of serious psychological distress in relationship to healthcare utilization indicators. A guiding hypothesis was that somatization underlying emotional states contributes to excessive healthcare seeking among adults with serious psychological distress...
December 2016: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/27888700/negative-mood-and-interference-control-in-nonsuicidal-self-injury
#6
Kenneth J D Allen, Jill M Hooley
People who engage in nonsuicidal self-injury (NSSI) often report high levels of impulsivity. However, results from behavioral tasks measuring impulsivity have been mixed: those with a history of NSSI generally perform comparably to healthy controls. Recent research suggests, however, that people who self-injure have specific deficits in response inhibition to negative emotional stimuli. Here, we extend this work by testing whether negative mood impairs interference control in NSSI. 33 participants reporting a history of NSSI (approximately half in the past year) and 31 age- and gender-matched healthy controls completed the multi-source interference task before and after a written negative mood induction designed to increase feelings of worthlessness, guilt, and shame...
November 4, 2016: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/27837383/exploring-measurement-invariance-by-gender-in-the-profile-of-mood-states-depression-subscale-among-cancer-survivors
#7
Jihye Kim, Tenbroeck Smith
PURPOSE: The Profile of Mood States-Short Form (POMS-SF) is a well-validated tool commonly used in medical/clinical research. Less attention has been paid to the measurement invariance of the POMS-the degree to which the structure and items behave similarly for different groups (e.g., women and men). This study investigated the measurement invariance of the POMS Depression subscale across gender groups in a sample of cancer survivors. METHODS: The POMS Depression subscale has 8 items (Unhappy, Sad, Blue, Hopeless, Discouraged, Miserable, Helpless, and Worthless)...
January 2017: Quality of Life Research
https://www.readbyqxmd.com/read/27833645/the-impact-of-psychopathological-subtypes-on-retention-rate-of-patients-with-substance-use-disorder-entering-residential-therapeutic-community-treatment
#8
Angelo G I Maremmani, Pier Paolo Pani, Emanuela Trogu, Federica Vigna-Taglianti, Federica Mathis, Roberto Diecidue, Ursula Kirchmayer, Laura Amato, Joli Ghibaudi, Antonella Camposeragna, Alessio Saponaro, Marina Davoli, Fabrizio Faggiano, Icro Maremmani
BACKGROUND: A specific psychopathology of addiction has been proposed and described using the self-report symptom inventory (SCL-90), leading to a 5-factor aggregation of psychological/psychiatric symptoms: 'worthlessness and being trapped', 'somatic symptoms', 'sensitivity-psychoticism', 'panic-anxiety' and 'violence-suicide' in various populations of patients with heroin use disorder (HUD) and other substance use disorders (SUDs). These clusters of symptoms, according to studies that have highlighted the role of possible confounding factors (such as demographic and clinical characteristics, active heroin use, lifetime psychiatric problems and kind of treatment received by the patients), seem to constitute a trait rather than a state of the psychological structure of addiction...
2016: Annals of General Psychiatry
https://www.readbyqxmd.com/read/27810714/symptom-quality-versus-quantity-in-judging-prognosis-using-nesarc-predictive-validators-to-locate-uncomplicated-major-depression-on-the-number-of-symptoms-severity-continuum
#9
Jerome C Wakefield, Mark F Schmitz
BACKGROUND: Uncomplicated major depressive disorder (UMDD) is defined as MDD that does not include any of six pathosuggestive features: more than six months duration, marked functional impairment, sense of worthlessness, suicidal ideation, psychotic ideation, and psychomotor retardation. Complicated MDD (CMDD) includes all episodes containing one or more of these features. UMDD has been shown to be lower than CMDD and indistinguishable from no-MDD-history on predictive pathology validators...
January 15, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27807727/positron-emission-tomography-computed-tomography-for-patients-with-recurrent-colorectal-liver-metastases-impact-on-restaging-and-treatment-planning
#10
Luca Viganò, Egesta Lopci, Guido Costa, Marcello Rodari, Dario Poretti, Vittorio Pedicini, Luigi Solbiati, Arturo Chiti, Guido Torzilli
BACKGROUND: The impact of fluorodeoxyglucose positron emission tomography-computed tomography (PET-CT) for patients with colorectal liver metastases (CLM) still is debated. Its relevance could be enhanced in the case of recurrent disease. The current study aimed to elucidate the role of PET-CT in restaging and treatment planning for recurrent CLM. METHODS: A series of 352 consecutive patients undergoing their first liver resection for CLM between 2005 and 2014 was reviewed...
November 2, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27773922/the-state-of-play-in-higher-eukaryote-gene-annotation
#11
Jonathan M Mudge, Jennifer Harrow
A genome sequence is worthless if it cannot be deciphered; therefore, efforts to describe - or 'annotate' - genes began as soon as DNA sequences became available. Whereas early work focused on individual protein-coding genes, the modern genomic ocean is a complex maelstrom of alternative splicing, non-coding transcription and pseudogenes. Scientists - from clinicians to evolutionary biologists - need to navigate these waters, and this has led to the design of high-throughput, computationally driven annotation projects...
October 24, 2016: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/27738127/non-partner-sexual-violence-against-women-in-spain-lifetime-prevalence-perpetrators-and-consequences-on-mental-health
#12
Ines Domenech Del Rio, Elena Sirvent Garcia Del Valle
BACKGROUND: Research on sexual violence by non-partners based on representative samples is scarce. The objectives of the study were (i) to analyse the prevalence of different forms of non-partner sexual violence in Spain and their perpetrators, (ii) to analyse the consequences of non-partner sexual violence on mental health and (iii) to estimate the percentage of rapes that are reported to the police. METHODS: Data from the 2015 Spanish Survey on Violence against Women, a nationally representative sample of 10 171 women, were used...
October 13, 2016: Journal of Public Health
https://www.readbyqxmd.com/read/27697136/childhood-depressive-disorders
#13
Rikke Thaarup Wesselhöft
Major depressive disorder (MDD) is a frequent and painful mental disorder considered among the five leading causes of disability in Western countries by the World Health Organization. MDD occurs at all ages, but childhood onset MDD has a more severe course with longer depressive episodes, more suicidality, and more frequent hospitalization, than later onset MDD. Childhood seems to be a window of opportunity for prevention of mental disorders, and subsequently prevention of MDD onset in childhood is recommended...
October 2016: Danish Medical Journal
https://www.readbyqxmd.com/read/27690352/reconsidering-the-definition-of-major-depression-based-on-collaborative-psychiatric-epidemiology-surveys
#14
Tom Rosenström, Markus Jokela
BACKGROUND: Diagnostic definitions for depressive disorders remain a debated topic, despite their central role in clinical practice and research. We use both recent evidence and nationally representative data to derive an empirically-based modification of DSM-IV/-5 Major Depressive Disorder (MDD). METHOD: A modified MDD diagnosis was derived by analyzing data from Collaborative Psychiatric Epidemiology Surveys, a multistage probability sample of adults (n=20 013; age ≥ 18 years) in coterminous USA, Alaska and Hawaii...
September 20, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27593209/mixed-mania-associated-with-cessation-of-breastfeeding
#15
Kristen A Schmidt, Brian A Palmer, Mark A Frye
BACKGROUND: This case chronicles the unique presentation of psychotic mixed mania in a female 5 months after parturition and 1 week following breastfeeding discontinuation, highlighting a rarely recognized mania risk factor that is temporally delayed from parturition: breastfeeding discontinuation. CASE PRESENTATION: A 25-year-old G1P1 female with a past psychiatric history of a depressive episode in adolescence presented to the Emergency Department with her 5-month-old daughter, fiancée, and family 1 week after breastfeeding cessation...
December 2016: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/27588241/an-alternative-data-filling-approach-for-prediction-of-missing-data-in-soft-sets-adfis
#16
Muhammad Sadiq Khan, Mohammed Ali Al-Garadi, Ainuddin Wahid Abdul Wahab, Tutut Herawan
Soft set theory is a mathematical approach that provides solution for dealing with uncertain data. As a standard soft set, it can be represented as a Boolean-valued information system, and hence it has been used in hundreds of useful applications. Meanwhile, these applications become worthless if the Boolean information system contains missing data due to error, security or mishandling. Few researches exist that focused on handling partially incomplete soft set and none of them has high accuracy rate in prediction performance of handling missing data...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27563461/an-eco-friendly-method-of-synthesizing-gold-nanoparticles-using-an-otherwise-worthless-weed-pistia-pistia-stratiotes-l
#17
J Anuradha, Tasneem Abbasi, S A Abbasi
A biomimetic method of gold nanoparticles synthesis utilizing the highly invasive aquatic weed pistia (Pistia stratiotes) is presented. In an attempt to utilize the entire plant, the efficacy of the extracts of all its parts - aerial and submerged - was explored with different proportions of gold (III) solution in generating gold nanoparticles (GNPs). The progress of the synthesis, which occurred at ambient temperature and pressure and commenced soon after mixing the pistia extracts and gold (III) solutions, was tracked using UV-visible spectrophotometry...
September 2015: Journal of Advanced Research
https://www.readbyqxmd.com/read/27531729/association-of-socioeconomic-status-with-psychiatric-problems-and-violent-behaviours-in-a-nationally-representative-sample-of-iranian-children-and-adolescents-the-caspian-iv-study
#18
Ramin Heshmat, Mostafa Qorbani, Behnaz Ghoreshi, Shirin Djalalinia, Omid Reza Tabatabaie, Saeid Safiri, Mehdi Noroozi, Mohammad-Esmaeil Motlagh, Zeinab Ahadi, Hamid Asayesh, Roya Kelishadi
OBJECTIVES: The aim of the present study was to evaluate the association between socioeconomic status (SES) and psychiatric problems and violent behaviours in a nationally representative sample of Iranian children and adolescents, based on nationwide surveillance programme data, 2011-2012. METHODS: Overall, 14 880 students, aged 6-18 years, were selected using a multistage cluster sampling method from rural and urban areas of 30 provinces in Iran. SES was estimated based on a main summarised component, extracted from principle component analysis of family assets and parents' jobs and education...
2016: BMJ Open
https://www.readbyqxmd.com/read/27495926/antimicrobial-agents-optimising-the-ecological-balance
#19
EDITORIAL
Sze-Ann Woon, Dale Fisher
BACKGROUND: There is no more challenging a group of pharmaceuticals than antimicrobials. With the antibiotic era came great optimism as countless deaths were prevented from what were previously fatal conditions. Although antimicrobial resistance was quickly identified, the abundance of antibiotics entering the market helped cement attitudes of arrogance as the "battle against pestilence appeared won". Opposite emotions soon followed as many heralded the return of the pre-antibiotic era, suggesting that the "antibiotic pipeline had dried up" and that our existing armament would soon be rendered worthless...
2016: BMC Medicine
https://www.readbyqxmd.com/read/27472872/a-depressive-endophenotype-for-predicting-cognitive-decline-among-mexican-american-adults-and-elders
#20
Leigh A Johnson, Adriana Gamboa, Raul Vintimilla, Melissa Edwards, James Hall, Brent Weiser, Menaka Yadav, Tony Dickensheets, Sid E O'Bryant
BACKGROUND: Late life depression is a prodromal feature and a risk factor for Alzheimer's disease (AD) and mild cognitive impairment (MCI). We identified five items in the Geriatric Depression scale (DepE) that are important as a risk for MCI and AD: memory problems, feeling blue, crying, feeling worthless, and trouble concentrating. OBJECTIVE: Our goal was to examine the relationship between DepE and cognition in a cohort of Mexican Americans. METHODS: Data from 317 Mexican Americans from the HABLE study were analyzed...
July 25, 2016: Journal of Alzheimer's Disease: JAD
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