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JOURNAL ARTICLE
Yuan Yan Sin, Ryan T Cameron, Melissa Schepers, Ruth MacLeod, Tom A Wright, Dean Paes, Daniel van den Hove, Emily Willems, Tim Vanmierlo, Jos Prickaerts, Connor M Blair, George S Baillie
Inhibition of the cyclic-AMP degrading enzyme phosphodiesterase type 4 (PDE4) in the brains of animal models is protective in Alzheimer's disease (AD). We show for the first time that enzymes from the subfamily PDE4D not only colocalize with beta-amyloid (Aβ) plaques in a mouse model of AD but that Aβ directly associates with the catalytic machinery of the enzyme. Peptide mapping suggests that PDE4D is the preferential PDE4 subfamily for Aβ as it possesses a unique binding site. Intriguingly, exogenous addition of Aβ to cells overexpressing the PDE4D5 longform caused PDE4 activation and a decrease in cAMP...
May 9, 2024: FEBS Letters
#22
JOURNAL ARTICLE
Robert J H Miller, Aakash Shanbhag, Anna M Michalowska, Paul Kavanagh, Joanna X Liang, Valerie Builoff, Nowell M Fine, Damini Dey, Daniel S Berman, Piotr J Slomka
Transthyretin cardiac amyloidosis (ATTR CA) is increasingly recognized as a cause of heart failure in older patients, with 99m Tc-pyrophosphate imaging frequently used to establish the diagnosis. Visual interpretation of SPECT images is the gold standard for interpretation but is inherently subjective. Manual quantitation of SPECT myocardial 99m Tc-pyrophosphate activity is time-consuming and not performed clinically. We evaluated a deep learning approach for fully automated volumetric quantitation of 99m Tc-pyrophosphate using segmentation of coregistered anatomic structures from CT attenuation maps...
May 9, 2024: Journal of Nuclear Medicine
#23
JOURNAL ARTICLE
Nicholas W Bateman, Tamara Abulez, Christopher M Tarney, Maria V Bariani, Jordan A Driscoll, Anthony R Soltis, Ming Zhou, Brian L Hood, Tracy Litzi, Kelly A Conrads, Amanda Jackson, Julie Oliver, Satishkumar Ranganathan Ganakammal, Frank Schneider, Clifton L Dalgard, Matthew D Wilkerson, Barbara Smith, Victor Borda, Timothy O'Connor, James Segars, S Abbas Shobeiri, Neil T Phippen, Kathleen M Darcy, Ayman Al-Hendy, Thomas P Conrads, George Larry Maxwell
BACKGROUND: Black women are at an increased risk to develop uterine leiomyomas (ULMs) and to experience worse disease prognosis compared to White women. Epidemiological and molecular factors have been identified as underlying these disparities, but there remains a paucity of deep, multi-omic analysis investigating molecular differences in ULMs from Black and White patients. OBJECTIVE: To identify molecular alterations within ULM tissues correlating with patient race by multi-omic analyses of ULMs collected from cohorts of Black and White women...
May 7, 2024: American Journal of Obstetrics and Gynecology
#24
REVIEW
Ana F R Gomes, Mariana C Almeida, Emília Sousa, Diana I S P Resende
Siderophores are small molecules of organic nature, released by bacteria to chelate iron from the surrounding environment and subsequently incorporate it into the cytoplasm. In addition to iron, these secondary metabolites can complex with a wide variety of metals, which is why they are commonly studied in the environment. Heavy metals can be very toxic when present in large amounts on the planet, affecting public health and all living organisms. The pollution caused by these toxic metals is increasing, and therefore it is urgent to find practical, sustainable, and economical solutions for remediation...
May 7, 2024: Science of the Total Environment
#25
JOURNAL ARTICLE
Rajneesh Sharma, Matthew R Levi, Matthew C Ricker, Aaron Thompson, Elizabeth G King, Kevin Robertson
Soil organic carbon (SOC) is a dynamic soil property (DSP) that represents the largest portion of terrestrial carbon. Its relevance to carbon sequestration and the potential effects of land use on SOC storage, make it imperative to map across both space and time. Most regional-scale studies mapping SOC give static estimates and train different models for different periods with varying accuracies. We developed a flexible modeling approach called DSP-Scale to map SOC in both space and time. DSP-Scale uses ecological concepts and empirical data to predict DSP dynamics using inherent soil properties (static factors) and land cover changes (dynamic factors)...
May 7, 2024: Science of the Total Environment
#26
JOURNAL ARTICLE
Andrea Reiter, Emely L Verweyen, Emmanuelle Queste, Sabrina Fuehner, André Jakob, Katja Masjosthusmann, Claas Hinze, Helmut Wittkowski, Dirk Foell, Ulrich Meinzer, Isabelle Melki, Christoph Kessel
Multisystem inflammatory syndrome in children (MIS-C) shares several clinical and immunological features with Kawasaki Disease (KD) and pediatric hyperinflammation, but the immuno-phenotypic overlap among these clinical mimics is still incompletely understood. Here we analyzed serum samples from treatment-naïve patients with MIS-C (n = 31) and KD (n = 11), pediatric hyperinflammation (n = 13) and healthy controls (HC, n = 10) by proximity extension assay (PEA) to profile 184 blood biomarkers...
May 7, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
#27
JOURNAL ARTICLE
Eileen O Dareng, Simon G Coetzee, Jonathan P Tyrer, Pei-Chen Peng, Will Rosenow, Stephanie Chen, Brian D Davis, Felipe Segato Dezem, Ji-Heui Seo, Robbin Nameki, Alberto L Reyes, Katja K H Aben, Hoda Anton-Culver, Natalia N Antonenkova, Gerasimos Aravantinos, Elisa V Bandera, Laura E Beane Freeman, Matthias W Beckmann, Alicia Beeghly-Fadiel, Javier Benitez, Marcus Q Bernardini, Line Bjorge, Amanda Black, Natalia V Bogdanova, Kelly L Bolton, James D Brenton, Agnieszka Budzilowska, Ralf Butzow, Hui Cai, Ian Campbell, Rikki Cannioto, Jenny Chang-Claude, Stephen J Chanock, Kexin Chen, Georgia Chenevix-Trench, Yoke-Eng Chiew, Linda S Cook, Anna DeFazio, Joe Dennis, Jennifer A Doherty, Thilo Dörk, Andreas du Bois, Matthias Dürst, Diana M Eccles, Gabrielle Ene, Peter A Fasching, James M Flanagan, Renée T Fortner, Florentia Fostira, Aleksandra Gentry-Maharaj, Graham G Giles, Marc T Goodman, Jacek Gronwald, Christopher A Haiman, Niclas Håkansson, Florian Heitz, Michelle A T Hildebrandt, Estrid Høgdall, Claus K Høgdall, Ruea-Yea Huang, Allan Jensen, Michael E Jones, Daehee Kang, Beth Y Karlan, Anthony N Karnezis, Linda E Kelemen, Catherine J Kennedy, Elza K Khusnutdinova, Lambertus A Kiemeney, Susanne K Kjaer, Jolanta Kupryjanczyk, Marilyne Labrie, Diether Lambrechts, Melissa C Larson, Nhu D Le, Jenny Lester, Lian Li, Jan Lubiński, Michael Lush, Jeffrey R Marks, Keitaro Matsuo, Taymaa May, John R McLaughlin, Iain A McNeish, Usha Menon, Stacey Missmer, Francesmary Modugno, Melissa Moffitt, Alvaro N Monteiro, Kirsten B Moysich, Steven A Narod, Tu Nguyen-Dumont, Kunle Odunsi, Håkan Olsson, N Charlotte Onland-Moret, Sue K Park, Tanja Pejovic, Jennifer B Permuth, Anna Piskorz, Darya Prokofyeva, Marjorie J Riggan, Harvey A Risch, Cristina Rodríguez-Antona, Mary Anne Rossing, Dale P Sandler, V Wendy Setiawan, Kang Shan, Honglin Song, Melissa C Southey, Helen Steed, Rebecca Sutphen, Anthony J Swerdlow, Soo Hwang Teo, Kathryn L Terry, Pamela J Thompson, Liv Cecilie Vestrheim Thomsen, Linda Titus, Britton Trabert, Ruth Travis, Shelley S Tworoger, Ellen Valen, Els Van Nieuwenhuysen, Digna Velez Edwards, Robert A Vierkant, Penelope M Webb, Clarice R Weinberg, Rayna Matsuno Weise, Nicolas Wentzensen, Emily White, Stacey J Winham, Alicja Wolk, Yin-Ling Woo, Anna H Wu, Li Yan, Drakoulis Yannoukakos, Nur Zeinomar, Wei Zheng, Argyrios Ziogas, Andrew Berchuck, Ellen L Goode, David G Huntsman, Celeste L Pearce, Susan J Ramus, Thomas A Sellers, Matthew L Freedman, Kate Lawrenson, Joellen M Schildkraut, Dennis Hazelett, Jasmine T Plummer, Siddhartha Kar, Michelle R Jones, Paul D P Pharoah, Simon A Gayther
To identify credible causal risk variants (CCVs) associated with different histotypes of epithelial ovarian cancer (EOC), we performed genome-wide association analysis for 470,825 genotyped and 10,163,797 imputed SNPs in 25,981 EOC cases and 105,724 controls of European origin. We identified five histotype-specific EOC risk regions (p value <5 × 10-8 ) and confirmed previously reported associations for 27 risk regions. Conditional analyses identified an additional 11 signals independent of the primary signal at six risk regions (p value <10-5 )...
May 7, 2024: American Journal of Human Genetics
#28
JOURNAL ARTICLE
William Wilson, Negar Tehrani, Daniel J Pittman, Perry Dykens, Victoria Mosher, Laura Gill, Joseph Peedicail, Antis G George, Craig A Beers, Bradley Goodyear, Pierre LeVan, Paolo Federico
Various subjective and objective methods have been proposed to identify which interictal epileptiform discharge (IED)-related EEG-fMRI results are more likely to delineate seizure generating tissue in patients with drug-resistant focal epilepsy for the purposes of surgical planning. In this intracranial EEG-fMRI study, we evaluated the utility of these methods to localize clinically relevant regions pre-operatively and compared the extent of resection of these areas to post-operative outcome. Seventy patients admitted for intracranial video-EEG monitoring were recruited for a simultaneous intracranial EEG-fMRI study...
May 9, 2024: Brain
#29
JOURNAL ARTICLE
Giuseppe Parrella, Benoit Moury
Tobacco vein necrosis (TVN) is a complex phenomenon regulated by different genetic determinants mapped in the HC-Pro protein (amino acids N330, K391 and E410) and in two regions of potato virus Y (PVY) genome, corresponding to the cytoplasmic inclusion (CI) protein and the nuclear inclusion protein a-protease (NIa-Pro), respectively. A new determinant of TVN was discovered in the MK isolate of PVY which, although carried the HC-Pro determinants associated to TVN, did not induce TVN. The HC-Pro open reading frame (ORF) of the necrotic infectious clone PVY N605 was replaced with that of the non-necrotic MK isolate, which differed only by one amino acid at position 392 (T392 instead of I392)...
2024: PloS One
#30
JOURNAL ARTICLE
Gloria Zaffaroni, Alessandro Mannucci, Laura Koskenvuo, Borja de Lacy, Anna Maffioli, Tanya Bisseling, Elizabeth Half, Giulia Martina Cavestro, Laura Valle, Neil Ryan, Stefan Aretz, Karen Brown, Francesco Buttitta, Fatima Carneiro, Oonagh Claber, Ruth Blanco-Colino, Maxime Collard, Emma Crosbie, Miguel Cunha, Triantafyllos Doulias, Christina Fleming, Henriette Heinrich, Robert Hüneburg, Julie Metras, Iris Nagtegaal, Ionut Negoi, Maartje Nielsen, Gianluca Pellino, Luigi Ricciardiello, Abdurrahman Sagir, Luis Sánchez-Guillén, Toni T Seppälä, Peter Siersema, Benedikt Striebeck, Julian R Sampson, Andrew Latchford, Yann Parc, John Burn, Gabriela Möslein
BACKGROUND: Hereditary adenomatous polyposis syndromes, including familial adenomatous polyposis and other rare adenomatous polyposis syndromes, increase the lifetime risk of colorectal and other cancers. METHODS: A team of 38 experts convened to update the 2008 European recommendations for the clinical management of patients with adenomatous polyposis syndromes. Additionally, other rare monogenic adenomatous polyposis syndromes were reviewed and added. Eighty-nine clinically relevant questions were answered after a systematic review of the existing literature with grading of the evidence according to Grading of Recommendations, Assessment, Development, and Evaluation methodology...
May 3, 2024: British Journal of Surgery
#31
JOURNAL ARTICLE
Geneviève Jessiman-Perreault, Jean-Christophe Boucher, So Youn Kim, Nicole Frenette, Abbas Badami, Henry M Smith, Lisa K Allen Scott
BACKGROUND: Attitudes toward the human papillomavirus (HPV) vaccine and accuracy of information shared about this topic in web-based settings vary widely. As real-time, global exposure to web-based discourse about HPV immunization shapes the attitudes of people toward vaccination, the spread of misinformation and misrepresentation of scientific knowledge contribute to vaccine hesitancy. OBJECTIVE: In this study, we aimed to better understand the type and quality of scientific research shared on Twitter (recently rebranded as X) by vaccine-hesitant and vaccine-confident communities...
May 9, 2024: JMIR Infodemiology
#32
JOURNAL ARTICLE
Priya Balasubramanian, Roxanne P De Leon, Dylan B Snyder, Scott A Beardsley, Allison S Hyngstrom, Brian D Schmit
This study describes electroencephalography (EEG) measurements during a simple finger movement in people with stroke to understand how temporal patterns of cortical activation and network connectivity align with prolonged muscle contraction at the end of a task. We investigated changes in the EEG temporal patterns in the beta band (13-26 Hz) of people with chronic stroke (N = 10, 7 F/3 M) and controls (N = 10, 7 F/3 M), during and after a cued movement of the index finger...
May 9, 2024: Brain Topography
#33
JOURNAL ARTICLE
Supplitt Stanislaw, Karpinski Pawel, Sasiadek Maria, Laczmanski Lukasz, Kujawa Dorota, Matkowski Rafal, Kasprzak Piotr, Abrahamowska Mariola, Maciejczyk Adam, Iwaneczko Ewelina, Laczmanska Izabela
Neoadjuvant chemotherapy is the foundation treatment for triple-negative breast cancer (TNBC) and frequently results in pathological complete response (pCR). However, there are large differences in clinical response and survival after neoadjuvant chemotherapy of TNBC patients. The aim was to identify genes whose expression significantly associates with the efficacy of neoadjuvant chemotherapy in patients with TNBC. Transcriptomes of 46 formalin-fixed paraffin-embedded (FFPE) tumor samples from TNBC patients were analyzed by RNA-seq by comparing 26 TNBCs with pCR versus 20 TNBCs with pathological partial remission (pPR)...
May 9, 2024: Journal of Applied Genetics
#34
JOURNAL ARTICLE
Syed Ahmed Nadeem, Alejandro P Comellas, Elizabeth A Regan, Eric A Hoffman, Punam K Saha
BACKGROUND: Spinal degeneration and vertebral compression fractures are common among the elderly that adversely affect their mobility, quality of life, lung function, and mortality. Assessment of vertebral fractures in chronic obstructive pulmonary disease (COPD) is important due to the high prevalence of osteoporosis and associated vertebral fractures in COPD. PURPOSE: We present new automated methods for (1) segmentation and labelling of individual vertebrae in chest computed tomography (CT) images using deep learning (DL), multi-parametric freeze-and-grow (FG) algorithm, and separation of apparently fused vertebrae using intensity autocorrelation and (2) vertebral deformity fracture detection using computed vertebral height features and parametric computational modelling of an established protocol outlined for trained human experts...
May 9, 2024: Medical Physics
#35
JOURNAL ARTICLE
Martina Rossi, Nirad Banskota, Chang Hoon Shin, Carlos Anerillas, Dimitrios Tsitsipatis, Jen-Hao Yang, Rachel Munk, Jennifer L Martindale, Xiaoling Yang, Yulan Piao, Krystyna Mazan-Mamczarz, Jinshui Fan, Elin Lehrmann, Kwan-Wood Gabriel Lam, Supriyo De, Kotb Abdelmohsen, Myriam Gorospe
RNA modifications, including N6-methyladenosine (m6A), critically modulate protein expression programs in a range of cellular processes. Although the transcriptomes of cells undergoing senescence are strongly regulated, the landscape and impact of m6A modifications during senescence are poorly understood. Here, we report a robust m6A modification of PTCHD4 mRNA, encoding Patched Domain-Containing Protein 4, in senescent cells. The METTL3/METTL14 complex was found to incorporate the m6A modification on PTCHD4 mRNA; addition of m6A rendered PTCHD4 mRNA more stable and increased PTCHD4 production...
May 9, 2024: Nucleic Acids Research
#36
JOURNAL ARTICLE
Matthew Buckley, Anthony McGregor, Niklas Ihssen, Joseph Austen, Simon Thurlbeck, Shamus P Smith, Armin Heinecke, Adina R Lew
Classic research has shown a division in the neuroanatomical structures that support flexible (e.g., short-cutting) and habitual (e.g., familiar route following) navigational behavior, with hippocampal-caudate systems associated with the former and putamen systems with the latter. There is, however, disagreement about whether the neural structures involved in navigation process particular forms of spatial information, such as associations between constellations of cues forming a cognitive map, versus single landmark-action associations, or alternatively, perform particular reinforcement learning algorithms that allow the use of different spatial strategies, so-called model-based (flexible) or model-free (habitual) forms of learning...
May 9, 2024: Hippocampus
#37
JOURNAL ARTICLE
Fredrika Rask, Erik Uvelius, Niklas Marklund
INTRODUCTION: The American Association of Neurologic Surgeons guidelines on the management of traumatic spinal cord injury (SCI), updated in 2013, focus on spinal cord perfusion, early decompressive surgery, and venous thromboembolism (VTE) prophylaxis to improve neurological outcome. RESEARCH QUESTION: How neurocritical care and initial management have changed with the implementation of updated management guidelines, focusing on guidelines adherence and neurological outcome...
2024: Brain Spine
#38
JOURNAL ARTICLE
Quynh Mai Thai, Phuong-Thao Tran, Huong T T Phung, Minh Quan Pham, Son Tung Ngo
The aggregation of amyloid beta (Aβ) peptides is associated with the development of Alzheimer's disease (AD). However, there has been a growing belief that the oligomerization of Aβ species in different environments has a neurotoxic effect on the patient's brain, causing damage. It is necessary to comprehend the compositions of Aβ oligomers in order to develop medications that may effectively inhibit these neurotoxic forms that affect the nervous system of AD patients. Thus, dissociation or inhibition of Aβ aggregation may be able to prevent AD...
May 2, 2024: RSC Advances
#39
JOURNAL ARTICLE
Cheng-Wei Tie, Ji-Qing Zhu, Zhan Yu, Li-Zhou Dou, Mei-Ling Wang, Gui-Qi Wang, Xiao-Guang Ni
INTRODUCTION: Hypopharyngeal squamous cell carcinoma (HSCC) is one of the malignant tumors with the worst prognosis in head and neck cancers. The transformation from normal tissue through low-grade and high-grade intraepithelial neoplasia to cancerous tissue in HSCC is typically viewed as a progressive pathological sequence typical of tumorigenesis. Nonetheless, the alterations in diverse cell clusters within the tissue microenvironment (TME) throughout tumorigenesis and their impact on the development of HSCC are yet to be fully understood...
2024: Frontiers in Immunology
#40
JOURNAL ARTICLE
Mei Wang, Congjing Yu, Mianwen Li, Xinru Zhang, Kexin Jiang, Zhiyong Zhang, Xiaodong Zhang
BACKGROUND: Anterior cruciate ligament (ACL) injuries are closely associated with knee osteoarthritis (OA). However, diagnosing ACL injuries based on knee magnetic resonance imaging (MRI) has been subjective and time-consuming for clinical doctors. Therefore, we aimed to devise a deep learning (DL) model leveraging MRI to enable a comprehensive and automated approach for the detection of ACL injuries. METHODS: A retrospective study was performed extracting data from the Osteoarthritis Initiative (OAI)...
May 1, 2024: Quantitative Imaging in Medicine and Surgery
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