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https://www.readbyqxmd.com/read/29792975/bladder-agenesis-and-associated-pelvic-arterial-anomaly-in-two-female-pediatric-patients
#1
Thomas Lowrey, Shellie Josephs, Linda A Baker
Bladder agenesis is an extremely rare congenital anomaly of the genitourinary tract. Two female patients with known diagnoses of bladder agenesis presented for pre-renal transplant evaluation and neobladder creation. Similar unique pelvic arterial malformations were identified through pre-operative imaging and intraoperative examination. With these similar findings, it could be proposed that such anatomical variants are products of the same insult or involve a causal relationship, with vascular aberrancies potentially provoking pelvic organ maldevelopment...
May 21, 2018: Urology
https://www.readbyqxmd.com/read/29792942/optimisation-of-decontamination-method-and-influence-of-culture-media-on-the-recovery-of-mycobacterium-avium-subspecies-paratuberculosis-from-spiked-water-sediments
#2
G Aboagye, M T Rowe
The recovery of Mycobacterium avium subspecies paratuberculosis (Map) from the environment can be a laborious process - owing to Map being fastidious, its low number, and also high numbers of other microbial populations in such settings. Protocols i.e. filtration, decontamination and modified elution were devised to recover Map from spiked water sediments. Three culture media: Herrold's Egg Yolk Media (HEYM), Middlebrook 7H10 (M-7H10) and Bactec 12B were then employed to grow the organism following its elution...
May 21, 2018: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/29792238/mapping-the-neuroanatomic-substrates-of-cognition-in-familial-attention-deficit-hyperactivity-disorder
#3
Rachel Muster, Saadia Choudhury, Wendy Sharp, Steven Kasparek, Gustavo Sudre, Philip Shaw
BACKGROUND: While the neuroanatomic substrates of symptoms of attention deficit hyperactivity disorder (ADHD) have been investigated, less is known about the neuroanatomic correlates of cognitive abilities pertinent to the disorder, particularly in adults. Here we define the neuroanatomic correlates of key cognitive abilities and determine if there are associations with histories of psychostimulant medication. METHODS: We acquired neuroanatomic magnetic resonance imaging data from 264 members of 60 families (mean age 29...
May 24, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29792210/quantitative-cardiovascular-magnetic-resonance-extracellular-volume-native-t1-and-18f-fdg-pet-cmr-imaging-in-patients-after-revascularized-myocardial-infarction-and-association-with-markers-of-myocardial-damage-and-systemic-inflammation
#4
Karl P Kunze, Ralf J Dirschinger, Hans Kossmann, Franziska Hanus, Tareq Ibrahim, Karl-Ludwig Laugwitz, Markus Schwaiger, Christoph Rischpler, Stephan G Nekolla
BACKGROUND: Characterization of tissue integrity and inflammatory processes after acute myocardial infarction (AMI) using non-invasive imaging is predictive of patient outcome. Quantitative cardiovascular magnetic resonance (CMR) techniques such as native T1 and extracellular volume (ECV) mapping as well as 18 F-FDG positron emission tomography (PET) imaging targeting inflammatory cell populations are gaining acceptance, but are often applied without assessing their quantitative potential...
May 24, 2018: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29792207/metagenomic-analysis-of-viruses-associated-with-maize-lethal-necrosis-in-kenya
#5
Mwathi Jane Wamaitha, Deepti Nigam, Solomon Maina, Francesca Stomeo, Anne Wangai, Joyce Njoki Njuguna, Timothy A Holton, Bramwel W Wanjala, Mark Wamalwa, Tanui Lucas, Appolinaire Djikeng, Hernan Garcia-Ruiz
BACKGROUND: Maize lethal necrosis is caused by a synergistic co-infection of Maize chlorotic mottle virus (MCMV) and a specific member of the Potyviridae, such as Sugarcane mosaic virus (SCMV), Wheat streak mosaic virus (WSMV) or Johnson grass mosaic virus (JGMV). Typical maize lethal necrosis symptoms include severe yellowing and leaf drying from the edges. In Kenya, we detected plants showing typical and atypical symptoms. Both groups of plants often tested negative for SCMV by ELISA...
May 23, 2018: Virology Journal
https://www.readbyqxmd.com/read/29791686/extruded-upper-first-molar-intrusion-comparison-between-unilateral-and-bilateral-miniscrew-anchorage
#6
Mari Miura Sugii, Bruno de Castro Ferreira Barreto, Waldemir Francisco Vieira-Júnior, Katia Regina Izola Simone, Ataís Bacchi, Ricardo Armini Caldas
OBJECTIVE: The aim of his study was to evaluate the stress on tooth and alveolar bone caused by orthodontic intrusion forces in a supraerupted upper molar, by using a three-dimensional Finite Element Method (FEM). METHODS: A superior maxillary segment was modeled in the software SolidWorks 2010 (SolidWorks Corporation, Waltham, MA, USA) containing: cortical and cancellous bone, supraerupted first molar, periodontal tissue and orthodontic components. A finite element model has simulated intrusion forces of 4N onto a tooth, directed to different mini-screw locations...
January 2018: Dental Press Journal of Orthodontics
https://www.readbyqxmd.com/read/29791587/association-study-of-aff1-rs340630-polymorphism-with-genetic-susceptibility-to-rheumatoid-arthritis-in-chinese-population
#7
Qing-Qing Sun, Dong-Jin Hua, Si-Chao Huang, Han Cen, Li Zhou, Song Shao
This study was performed to examine whether the AF4/FMR2 family, member 1 (AFF1) rs340630 polymorphism is involved in the genetic background of rheumatoid arthritis (RA) in a Chinese population. Two different study groups of RA patients and controls (328 RA patients and 449 healthy controls in the first study group; 232 RA patients and 313 controls in the second study group) were included in our study. Overall, there was no significant difference in either genotype (P=0.71 and 0.64 in the first and second study group, respectively) nor allele (in the first study group: A vs G, P=0...
2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29791438/identity-by-descent-analyses-for-measuring-population-dynamics-and-selection-in-recombining-pathogens
#8
Lyndal Henden, Stuart Lee, Ivo Mueller, Alyssa Barry, Melanie Bahlo
Identification of genomic regions that are identical by descent (IBD) has proven useful for human genetic studies where analyses have led to the discovery of familial relatedness and fine-mapping of disease critical regions. Unfortunately however, IBD analyses have been underutilized in analysis of other organisms, including human pathogens. This is in part due to the lack of statistical methodologies for non-diploid genomes in addition to the added complexity of multiclonal infections. As such, we have developed an IBD methodology, called isoRelate, for analysis of haploid recombining microorganisms in the presence of multiclonal infections...
May 23, 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29791349/polarimetric-learning-a-siamese-approach-to-learning-distance-metrics-of-algal-mueller-matrix-images
#9
Xianpeng Li, Ran Liao, Hui Ma, Priscilla T Y Leung, Meng Yan
Polarimetric measurements are becoming increasingly accurate and fast to perform in modern applications. However, analysis on the polarimetric data usually suffers from its high-dimensional nature spatially, temporally, or spectrally. This paper associates polarimetric techniques with metric learning algorithms, namely, polarimetric learning, by introducing a distance metric learning method called Siamese network that aims to learn good distance metrics of algal Mueller matrix images in low-dimensional feature spaces...
May 10, 2018: Applied Optics
https://www.readbyqxmd.com/read/29790971/brain-activity-associated-with-attention-deficits-following-chemotherapy-for-childhood-acute-lymphoblastic-leukemia
#10
Slim Fellah, Yin T Cheung, Matthew A Scoggins, Ping Zou, Noah D Sabin, Ching-Hon Pui, Leslie L Robison, Melissa M Hudson, Robert J Ogg, Kevin R Krull
Background: The impact of contemporary chemotherapy treatment for childhood acute lymphoblastic leukemia on central nervous system activity is not fully appreciated. Methods: Neurocognitive testing and functional magnetic resonance imaging (fMRI) were obtained in 165 survivors five or more years postdiagnosis (average age = 14.4 years, 7.7 years from diagnosis, 51.5% males). Chemotherapy exposure was measured as serum concentration of methotrexate following high-dose intravenous injection...
May 21, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29790967/common-genetic-basis-of-eye-and-pigment-loss-in-two-distinct-cave-populations-of-the-isopod-crustacean-asellus-aquaticus
#11
Cassandra Re, Žiga Fišer, Justin Perez, Allyson Tacdol, Peter Trontelj, Meredith E Protas
Repeated evolution of similar phenotypes is a widespread phenomenon found throughout the living world and it can proceed through the same or different genetic mechanisms. Cave animals with their convergent traits such as eye and pigment loss, as well as elongated appendages, are a striking example of the evolution of similar phenotypes. Yet, few cave species are amenable to genetic crossing and mapping techniques making it challenging to determine the genetic mechanisms causing their similar phenotypes. To address this limitation, we have been developing Asellus aquaticus, a freshwater isopod crustacean, as a genetic model...
May 21, 2018: Integrative and Comparative Biology
https://www.readbyqxmd.com/read/29789914/correlation-based-perfusion-mapping-using-time-resolved-mr-angiography-a-feasibility-study-for-patients-with-suspicions-of-steno-occlusive-craniocervical-arteries
#12
Yoonho Nam, Jinhee Jang, Sonya Youngju Park, Hyun Seok Choi, So-Lyung Jung, Kook-Jin Ahn, Bum-Soo Kim
PURPOSE: To explore the feasibility of using correlation-based time-delay (CTD) maps produced from time-resolved MR angiography (TRMRA) to diagnose perfusion abnormalities in patients suspected to have steno-occlusive lesions in the craniocervical arteries. MATERIALS AND METHODS: Twenty-seven patients who were suspected to have steno-occlusive lesions in the craniocervical arteries underwent both TRMRA and brain single-photon emission computed tomography (SPECT)...
May 22, 2018: European Radiology
https://www.readbyqxmd.com/read/29789417/mapping-the-hla-ligandome-of-colorectal-cancer-reveals-an-imprint-of-malignant-cell-transformation
#13
Markus W Löffler, Daniel J Kowalewski, Linus Backert, Jörg Bernhardt, Patrick Adam, Heiko Schuster, Florian Dengler, Daniel Backes, Hans-Georg Kopp, Stefan Beckert, Silvia Wagner, Ingmar Königsrainer, Oliver Kohlbacher, Lothar Kanz, Alfred Königsrainer, Hans-Georg Rammensee, Stefan Stevanovic, Sebastian P Haen
Immune cell infiltrates have proven highly relevant for colorectal carcinoma (CRC) prognosis, making CRC a promising candidate for immunotherapy. Since tumors interact with the immune system via HLA-presented peptide ligands, exact knowledge of the peptidome constitution is fundamental for understanding this relationship. Here we comprehensively describe the naturally presented HLA-ligandome of CRC and corresponding non-malignant colon (NMC) tissue. Mass spectrometry identified 35,367 and 28,132 HLA-class I ligands on CRC and NMC, attributable to 7,684 and 6,312 distinct source proteins, respectively...
May 22, 2018: Cancer Research
https://www.readbyqxmd.com/read/29789386/antagonistic-interactions-between-two-map-kinase-cascades-in-plant-development-and-immune-signaling
#14
Tongjun Sun, Yukino Nitta, Qian Zhang, Di Wu, Hainan Tian, Jin Suk Lee, Yuelin Zhang
Mitogen-activated protein kinase (MAPK) signaling plays important roles in diverse biological processes. In Arabidopsis , MPK3/MPK6, MKK4/MKK5, and the MAPKKK YODA (YDA) form a MAPK pathway that negatively regulates stomatal development. Brassinosteroid (BR) stimulates this pathway to inhibit stomata production. In addition, MPK3/MPK6 and MKK4/MKK5 also serve as critical signaling components in plant immunity. Here, we report that MAPKKK3/MAPKKK5 form a kinase cascade with MKK4/MKK5 and MPK3/MPK6 to transduce defense signals downstream of multiple plant receptor kinases...
May 22, 2018: EMBO Reports
https://www.readbyqxmd.com/read/29788968/spatio-temporal-mapping-of-madagascar-s-malaria-indicator-survey-results-to-assess-plasmodium-falciparum-endemicity-trends-between-2011-and-2016
#15
Su Yun Kang, Katherine E Battle, Harry S Gibson, Arsène Ratsimbasoa, Milijaona Randrianarivelojosia, Stéphanie Ramboarina, Peter A Zimmerman, Daniel J Weiss, Ewan Cameron, Peter W Gething, Rosalind E Howes
BACKGROUND: Reliable measures of disease burden over time are necessary to evaluate the impact of interventions and assess sub-national trends in the distribution of infection. Three Malaria Indicator Surveys (MISs) have been conducted in Madagascar since 2011. They provide a valuable resource to assess changes in burden that is complementary to the country's routine case reporting system. METHODS: A Bayesian geostatistical spatio-temporal model was developed in an integrated nested Laplace approximation framework to map the prevalence of Plasmodium falciparum malaria infection among children from 6 to 59 months in age across Madagascar for 2011, 2013 and 2016 based on the MIS datasets...
May 23, 2018: BMC Medicine
https://www.readbyqxmd.com/read/29788801/perioperative-noninvasive-cardiac-output-monitoring-in-parturients-with-singleton-and-twin-pregnancies-undergoing-caesarean-section-under-spinal-anesthesia-with-prophylactic-phenylephrine-drip-a-prospective-observational-cohort-study
#16
S Orbach-Zinger, E Razinsky, I Bizman, S Firman, R Gat, A Davis, E Ashwal, A Shmueli, M Vaturi, R Gabbay-Benziv, L A Eidelman
INTRODUCTION: Spinal anesthesia is considered the gold standard anesthetic technique for cesarean deliveries (CD) but is associated with a high rate of hypotension. The recent international consensus recommends continuous prophylactic phenylephrine infusion (PPI) administered throughout CD to prevent hypotension. However little information is available on the hemodynamic profiles of women with twin pregnancies as compared to singleton pregnancies perioperatively. Therefore, in this study we aim we compare maternal hemodynamic changes both intraoperatively and postoperatively with the use of the NICAS bio impendence monitor in healthy singleton versus twin parturients undergoing CD deliveries with spinal anesthesia with PPI...
May 22, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29788417/poor-feed-efficiency-in-sheep-is-associated-with-several-structural-abnormalities-in-the-community-metabolic-network-of-their-ruminal-microbes
#17
Rocky D Patil, Melinda J Ellison, Sara M Wolff, Courtney Shearer, Anna M Wright, Rebecca R Cockrum, Kathy J Austin, William R Lamberson, Kristi M Cammack, Gavin C Conant
Ruminant animals have a symbiotic relationship with the microorganisms in their rumens. In this relationship, rumen microbes efficiently degrade complex plant-derived compounds into smaller digestible compounds, a process that is very likely associated with host animal feed efficiency. The resulting simpler metabolites can then be absorbed by the host and converted into other compounds by host enzymes. We used a microbial community metabolic network inferred from shotgun metagenomics data to assess how this metabolic system differs between animals that are able to turn ingested feedstuffs into body mass with high efficiency and those that are not...
May 18, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29788376/the-ocean-gene-atlas-exploring-the-biogeography-of-plankton-genes-online
#18
Emilie Villar, Thomas Vannier, Caroline Vernette, Magali Lescot, Miguelangel Cuenca, Aurélien Alexandre, Paul Bachelerie, Thomas Rosnet, Eric Pelletier, Shinichi Sunagawa, Pascal Hingamp
The Ocean Gene Atlas is a web service to explore the biogeography of genes from marine planktonic organisms. It allows users to query protein or nucleotide sequences against global ocean reference gene catalogs. With just one click, the abundance and location of target sequences are visualized on world maps as well as their taxonomic distribution. Interactive results panels allow for adjusting cutoffs for alignment quality and displaying the abundances of genes in the context of environmental features (temperature, nutrients, etc...
May 21, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29787932/initial-data-on-adsorption-of-cs-and-sr-to-the-surfaces-of-microplastics-with-biofilm
#19
Mathew P Johansen, Emily Prentice, Tom Cresswell, Nick Howell
The adsorption of radiocesium and radiostrontium onto a range of natural materials has been well quantified, but not for the new media of environmental plastics, which may have enhanced adsorption due to surface-weathering and development of biofilms. Microplastic samples were deployed in freshwater, estuarine and marine conditions, then characterised using infrared spectroscopy to document changes to the plastic surface (vs interior). Synchrotron elemental mapping data revealed surfaces that were well-covered by accumulation of reactive water solutes and sulphur, but, in contrast, had highly discrete coverage of elements such as Fe and Ti, indicating adhered mineral/clay-associated agglomerates that may increase overall adsorption capacity...
May 19, 2018: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/29787764/apobec3b-nuclear-localization-requires-two-distinct-n-terminal-domain-surfaces
#20
Daniel J Salamango, Jennifer L McCann, Özlem Demir, William L Brown, Rommie E Amaro, Reuben S Harris
The APOBEC3 family of cytosine deaminases catalyzes the conversion of cytosines-to-uracils in single-stranded DNA. Traditionally, these enzymes are associated with antiviral immunity and restriction of DNA-based pathogens. However, a role for these enzymes in tumor evolution and metastatic disease has also become evident. The primary APOBEC3 candidate in cancer mutagenesis is APOBEC3B (A3B) for three reasons: 1) A3B mRNA is upregulated in several different cancers, 2) A3B expression and mutational loads correlate with poor clinical outcomes, and 3) A3B is the only family member known to be constitutively nuclear...
May 19, 2018: Journal of Molecular Biology
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