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https://www.readbyqxmd.com/read/28806786/an-economic-evaluation-of-vector-control-in-the-age-of-a-dengue-vaccine
#1
Christopher Fitzpatrick, Alexander Haines, Mathieu Bangert, Andrew Farlow, Janet Hemingway, Raman Velayudhan
INTRODUCTION: Dengue is a rapidly emerging vector-borne Neglected Tropical Disease, with a 30-fold increase in the number of cases reported since 1960. The economic cost of the illness is measured in the billions of dollars annually. Environmental change and unplanned urbanization are conspiring to raise the health and economic cost even further beyond the reach of health systems and households. The health-sector response has depended in large part on control of the Aedes aegypti and Ae...
August 14, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28806731/climatic-niche-of-selinum-alatum-apiaceae-selineae-a-new-invasive-plant-species-in-central-europe-and-its-alterations-according-to-the-climate-change-scenarios-are-the-european-mountains-threatened-by-invasion
#2
Kamil Konowalik, Małgorzata Proćków, Jarosław Proćków
In recent years, a few established populations of Selinum alatum have been found in the Eastern Carpathians outside its native range that is the Caucasus and the Armenian Highlands. The species is spreading predominantly in Poland where it can outcompete native plants in certain cases. This study addresses a potential climatic niche of the plant with the special aims to illuminate future spreading and indicate areas suitable for invasion. Our results show that the extent of the favourable habitat of the species is broader than currently known...
2017: PloS One
https://www.readbyqxmd.com/read/28806705/multiparametric-monitoring-of-microbial-faecal-pollution-reveals-the-dominance-of-human-contamination-along-the-whole-danube-river
#3
A K T Kirschner, G H Reischer, S Jakwerth, D Savio, S Ixenmaier, E Toth, R Sommer, R L Mach, R Linke, A Eiler, S Kolarevic, A H Farnleitner
The microbial faecal pollution of rivers has wide-ranging impacts on a variety of human activities that rely on appropriate river water quality. Thus, detailed knowledge of the extent and origin of microbial faecal pollution is crucial for watershed management activities to maintain safe water use. In this study, the microbial faecal pollution levels were monitored by standard faecal indicator bacteria (SFIB) along a 2580 km stretch of the Danube, the world's most international river, as well as the Danube's most important tributaries...
July 22, 2017: Water Research
https://www.readbyqxmd.com/read/28806681/human-biomonitoring-of-polycyclic-aromatic-hydrocarbonsand-metals-in-the-general-population-residing-near-the-municipal-solid-waste-incinerator-of-modena-italy
#4
Maria Giulia Gatti, Petra Bechtold, Laura Campo, Giovanna Barbieri, Giulia Quattrini, Andrea Ranzi, Sabrina Sucato, Luca Olgiati, Elisa Polledri, Michael Romolo, Laura Iacuzio, Giuliano Carrozzi, Paolo Lauriola, Carlo A Goldoni, Silvia Fustinoni
BACKGROUND AND OBJECTIVES: A cross-sectional biomonitoring study was carried out to investigate exposure to incinerator emission in relation to the body burden of selected biomarkers in the population living around the plant. METHODS: Approximately 500 people, aged 18-69 yrs, living within 4 km from the incinerator were randomly selected form the population register. Exposure was measured through fall-out maps of particulate matter (PM), used as tracer for incinerator emissions...
August 5, 2017: Chemosphere
https://www.readbyqxmd.com/read/28806545/improvement-of-the-drought-indicators-system-in-the-j%C3%A3%C2%BAcar-river-basin-spain
#5
Tatiana Ortega-Gómez, Miguel A Pérez-Martín, Teodoro Estrela
Droughts are one of the gravest natural threats currently existing in the world and their occurrence and intensity might be exacerbated in the coming years due to climate change. The severe impacts that droughts cause to inland water resources and to the associated socio-economic activities justify the continuous monitoring of the drought. The case study presented shows a practical application of a distributed drought monitoring system implemented in a real river basin district, the Júcar River Basin District (43,000km(2)), where drought periods of marked intensity have occurred historically and the climate ranges from humid in the north to semiarid in the south...
August 11, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28805926/multiple-trait-genomewide-mapping-and-gene-network-analysis-for-scrotal-circumference-growth-curves-in-brahman-cattle
#6
A C C Soares, S E F Guimarães, M J Kelly, M R S Fortes, F F E Silva, L L Verardo, R Mota, S Moore
Fertility traits are economically important in cattle breeding programs. Scrotal circumference (SC) measures are repeatable, easily obtained, highly heritable, and positively correlated with female fertility traits and sperm quality traits in males. A useful approach to summarize SC measures over time is using nonlinear models, which summarize specific measures of SC in a few parameters with biological interpretation. This approach facilitates the selection of bulls with larger SC and maturity index (K), that is, early maturing animals...
August 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28805821/opposing-effects-of-cancer-type-specific-spop-mutants-on-bet-protein-degradation-and-sensitivity-to-bet-inhibitors
#7
Hana Janouskova, Geniver El Tekle, Elisa Bellini, Namrata D Udeshi, Anna Rinaldi, Anna Ulbricht, Tiziano Bernasocchi, Gianluca Civenni, Marco Losa, Tanya Svinkina, Craig M Bielski, Gregory V Kryukov, Luciano Cascione, Sara Napoli, Radoslav I Enchev, David G Mutch, Michael E Carney, Andrew Berchuck, Boris J N Winterhoff, Russell R Broaddus, Peter Schraml, Holger Moch, Francesco Bertoni, Carlo V Catapano, Matthias Peter, Steven A Carr, Levi A Garraway, Peter J Wild, Jean-Philippe P Theurillat
It is generally assumed that recurrent mutations within a given cancer driver gene elicit similar drug responses. Cancer genome studies have identified recurrent but divergent missense mutations affecting the substrate-recognition domain of the ubiquitin ligase adaptor SPOP in endometrial and prostate cancers. The therapeutic implications of these mutations remain incompletely understood. Here we analyzed changes in the ubiquitin landscape induced by endometrial cancer-associated SPOP mutations and identified BRD2, BRD3 and BRD4 proteins (BETs) as SPOP-CUL3 substrates that are preferentially degraded by endometrial cancer-associated SPOP mutants...
August 14, 2017: Nature Medicine
https://www.readbyqxmd.com/read/28805813/analysis-of-genome-wide-association-data-highlights-candidates-for-drug-repositioning-in-psychiatry
#8
Hon-Cheong So, Carlos Kwan-Long Chau, Wan-To Chiu, Kin-Sang Ho, Cho-Pong Lo, Stephanie Ho-Yue Yim, Pak-Chung Sham
Knowledge of psychiatric disease genetics has advanced rapidly during the past decade with the advent of genome-wide association studies (GWAS). However, less progress has been made in harnessing these data to reveal new therapies. Here we propose a framework for drug repositioning by comparing transcriptomes imputed from GWAS data with drug-induced gene expression profiles from the Connectivity Map database and apply this approach to seven psychiatric disorders. We found a number of repositioning candidates, many supported by preclinical or clinical evidence...
August 14, 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/28805500/chitin-receptor-mediated-activation-of-map-kinases-and-ros-production-in-rice-and-arabidopsis
#9
Tsutomu Kawasaki, Kenta Yamada, Satomi Yoshimura, Koji Yamaguchi
Rapid induction of plant immune responses is essential to inhibit colonization and invasion by pathogens. Plants can recognize pathogen-associated molecular patterns (PAMPs) including fungal chitin and bacterial flagellin using pattern-recognition receptors (PRRs), which trigger the intracellular activation of mitogen-activated protein kinase (MAPK) cascades and the production of reactive oxygen species (ROS). MAPK activation and ROS production play pivotal roles in the induction of robust immune responses...
August 14, 2017: Plant Signaling & Behavior
https://www.readbyqxmd.com/read/28805173/latent-traits-of-impulsivity-and-compulsivity-toward-dimensional-psychiatry
#10
S R Chamberlain, J Stochl, S A Redden, J E Grant
BACKGROUND: The concepts of impulsivity and compulsivity are commonly used in psychiatry. Little is known about whether different manifest measures of impulsivity and compulsivity (behavior, personality, and cognition) map onto underlying latent traits; and if so, their inter-relationship. METHODS: A total of 576 adults were recruited using media advertisements. Psychopathological, personality, and cognitive measures of impulsivity and compulsivity were completed...
August 14, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28804623/recent-advances-in-the-molecular-mechanisms-of-mayer-rokitansky-k%C3%A3-ster-hauser-syndrome
#11
Keiko Watanabe, Yusuke Kobayashi, Kouji Banno, Yusuke Matoba, Haruko Kunitomi, Kanako Nakamura, Masataka Adachi, Kiyoko Umene, Iori Kisu, Eiichiro Tominaga, Daisuke Aoki
Mayer-Rokitansky-Küster-Hauser syndrome (MRKHS) is a disease caused by congenital absence of the uterus and two-thirds of the upper vagina. The pathogenic mechanism of MRKHS may involve gene abnormalities, and there are various case reports associating MRKHS with the Wnt family member 4 (Wnt4) mutation. Analysis of genes mapped to regions in which deletion and duplication are frequently detected in patients with MRKHS has shown involvement of LIM homeobox 1 (LHX1), HNF1 homeobox B (HNF1B) and T-box 6 (TBX6)...
August 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28804450/whole-brain-mapping-of-the-inputs-and-outputs-of-the-medial-part-of-the-olfactory-tubercle
#12
Zhijian Zhang, Hongruo Zhang, Pengjie Wen, Xutao Zhu, Li Wang, Qing Liu, Jie Wang, Xiaobin He, Huadong Wang, Fuqiang Xu
The medial part of the olfactory tubercle (OT) is a brain structure located at the interface of the reward and olfactory system. It is closely related to pheromone-rewards, natural reinforcement, addiction and many other behaviors. However, the structure of the anatomic circuitry of the medial part of the OT is still unclear. In the present study, the medial part of the OT was found to be highly connected with a wide range of brain areas with the help of the pseudorabies virus tracing tool. In order to further investigate the detailed connections for specific neurons, another tracing tool - rabies virus was utilized for D1R-cre and D2R-cre mice...
2017: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/28803920/open-chromatin-profiling-in-hipsc-derived-neurons-prioritizes-functional-noncoding-psychiatric-risk-variants-and-highlights-neurodevelopmental-loci
#13
Marc P Forrest, Hanwen Zhang, Winton Moy, Heather McGowan, Catherine Leites, Leonardo E Dionisio, Zihui Xu, Jianxin Shi, Alan R Sanders, William J Greenleaf, Chad A Cowan, Zhiping P Pang, Pablo V Gejman, Peter Penzes, Jubao Duan
Most disease variants lie within noncoding genomic regions, making their functional interpretation challenging. Because chromatin openness strongly influences transcriptional activity, we hypothesized that cell-type-specific open chromatin regions (OCRs) might highlight disease-relevant noncoding sequences. To investigate, we mapped global OCRs in neurons differentiating from hiPSCs, a cellular model for studying neurodevelopmental disorders such as schizophrenia (SZ). We found that the OCRs are highly dynamic and can stratify GWAS-implicated SZ risk variants...
August 4, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/28803687/predictors-of-asymptomatic-radiation-induced-abdominal-atherosclerosis
#14
L Cella, R Liuzzi, P Romanelli, M Conson, V D'Avino, M Ottaviano, V Damiano, G Palmieri, R Pacelli, M Mancini
AIMS: To identify predictors of asymptomatic radiation-induced abdominal atherosclerosis in patients treated with radiotherapy and evaluated by abdominal vascular ultrasonography. MATERIALS AND METHODS: Forty-two testicular classic seminoma patients (median age 34 years, range 16-56) undergoing radical inguinal orchiectomy were analysed. Twenty-six patients underwent post-surgery radiotherapy (median total dose 25 Gy, range 25-43), two of them also received chemotherapy (CHT) and 16 patients were treated with surgery alone or by surgery followed by CHT (control group)...
August 10, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28803020/a-missense-mutation-in-pfas-phosphoribosylformylglycinamidine-synthase-is-likely-causal-for-embryonic-lethality-associated-with-the-mh1-haplotype-in-montb%C3%A3-liarde-dairy-cattle
#15
Pauline Michot, Sébastien Fritz, Anne Barbat, Mekki Boussaha, Marie-Christine Deloche, Cécile Grohs, Chris Hoze, Laurène Le Berre, Daniel Le Bourhis, Olivier Desnoes, Pascal Salvetti, Laurent Schibler, Didier Boichard, Aurélien Capitan
A candidate mutation in the sex hormone binding globulin gene was proposed in 2013 to be responsible for the MH1 recessive embryonic lethal locus segregating in the Montbéliarde breed. In this follow-up study, we excluded this candidate variant because healthy homozygous carriers were observed in large-scale genotyping data generated in the framework of the genomic selection program. We fine mapped the MH1 locus in a 702-kb interval and analyzed genome sequence data from the 1,000 bull genomes project and 54 Montbéliarde bulls (including 14 carriers and 40 noncarriers)...
August 9, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28802637/blood-pressure-responses-to-dietary-sodium-association-with-autonomic-cardiovascular-function-in-normotensive-adults
#16
Evan L Matthews, Michael S Brian, David G Edwards, Sean D Stocker, Megan M Wenner, William B Farquhar
Blood pressure responses to dietary sodium vary widely person-to-person. Salt sensitive rodent models display altered autonomic function, a trait thought to contribute to poor cardiovascular health. Thus, we hypothesized that increased salt sensitivity (SS) in normotensive humans would be associated with increased muscle sympathetic nerve activity (MSNA), decreased high frequency heart rate variability (HF-HRV), and decreased baroreflex sensitivity. Healthy normotensive men and women completed 1week of high (300mmol·day(-1)) and 1week of low (20mmol·day(-1)) dietary sodium (random order) with 24h mean arterial pressure (MAP) assessed on the last day of each diet to assess SS...
August 6, 2017: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/28802455/from-control-to-causation-validating-a-complex-systems-model-of-running-related-injury-development-and-prevention
#17
A Hulme, P M Salmon, R O Nielsen, G J M Read, C F Finch
INTRODUCTION: There is a need for an ecological and complex systems approach for better understanding the development and prevention of running-related injury (RRI). In a previous article, we proposed a prototype model of the Australian recreational distance running system which was based on the Systems Theoretic Accident Mapping and Processes (STAMP) method. That model included the influence of political, organisational, managerial, and sociocultural determinants alongside individual-level factors in relation to RRI development...
November 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/28802249/high-resolution-mapping-of-chromatin-conformation-in-cardiac-myocytes-reveals-structural-remodeling-of-the-epigenome-in-heart-failure
#18
Manuel Rosa-Garrido, Douglas J Chapski, Anthony D Schmitt, Todd H Kimball, Elaheh Karbassi, Emma Monte, Enrique Balderas, Matteo Pellegrini, Tsai-Ting Shih, Elizabeth Soehalim, David A Liem, Peipei Ping, Niels J Galjart, Shuxun Ren, Yibin Wang, Bing Ren, Thomas M Vondriska
Background -Cardiovascular disease is associated with epigenomic changes in the heart, however the endogenous structure of cardiac myocyte chromatin has never been determined. Methods -To investigate the mechanisms of epigenomic function in the heart, genome-wide chromatin conformation capture (Hi-C) and DNA sequencing were performed in adult cardiac myocytes following development of pressure overload-induced hypertrophy. Mice with cardiac-specific deletion of CTCF (a ubiquitous chromatin structural protein) were generated to explore the role of this protein in chromatin structure and cardiac phenotype...
August 11, 2017: Circulation
https://www.readbyqxmd.com/read/28801731/molecular-mapping-and-genomics-of-soybean-seed-protein-a-review-and-perspective-for-the-future
#19
REVIEW
Gunvant Patil, Rouf Mian, Tri Vuong, Vince Pantalone, Qijian Song, Pengyin Chen, Grover J Shannon, Tommy C Carter, Henry T Nguyen
Genetic improvement of soybean protein meal is a complex process because of negative correlation with oil, yield, and temperature. This review describes the progress in mapping and genomics, identifies knowledge gaps, and highlights the need of integrated approaches. Meal protein derived from soybean [Glycine max (L) Merr.] seed is the primary source of protein in poultry and livestock feed. Protein is a key factor that determines the nutritional and economical value of soybean. Genetic improvement of soybean seed protein content is highly desirable, and major quantitative trait loci (QTL) for soybean protein have been detected and repeatedly mapped on chromosomes (Chr...
August 11, 2017: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/28801672/sample-entropy-reveals-an-age-related-reduction-in-the-complexity-of-dynamic-brain
#20
Yanbing Jia, Huaguang Gu, Qiang Luo
Dynamic reconfiguration of the human brain is characterized by the nature of complexity. The purpose of this study was to measure such complexity and also analyze its association with age. We modeled the dynamic reconfiguration process by dynamic functional connectivity, which was established by resting-state functional magnetic resonance imaging (fMRI) data, and we measured complexity within the dynamic functional connectivity by sample entropy (SampEn). A brainwide map of SampEn in healthy subjects shows larger values in the caudate, the olfactory gyrus, the amygdala, and the hippocampus, and lower values in primary sensorimotor and visual areas...
August 11, 2017: Scientific Reports
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