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Chun-Chao Zhu, Tae-Han Kim, Felix Berlth, Shin-Hoo Park, Yun-Suhk Suh, Seong-Ho Kong, Hyuk-Joon Lee, Hui Cao, Han-Kwang Yang
BACKGROUND: Delayed gastric emptying is one of the most disturbing complications of pylorus-preserving gastrectomy (PPG) and it increases hospital stay. We investigated the clinical outcome of intraoperative manual dilatation of the pylorus as a preventive method of pyloric spasm after PPG. MATERIALS AND METHODS: We reviewed gastric cancer patients who underwent PPG between January 2014 and December 2016 at Seoul National University Hospital by a single surgeon...
March 13, 2018: Gastric Cancer
Shivanjali Kumar, Kamal Kumar, Sarita Bajaj, Ranjana Kumar, Atul Gogia, Atul Kakar, Shrishti Paul Byotra
Introduction: Diabetes is a major world-wide healthcare problem. Cost effective markers for screening and diagnosis of T2DM are the need of the day especially in developing and under-developed countries. Simple anthropometric measurements may help us in identifying individuals likely to have diabetes. Material and Methods: Data from 1055 North-Indian subjects was analysed. Results: Out of several anthropometric measurements studied, Waist-Thigh ratio (WTR) correlated significantly and positively with all three measures of diabetes i...
January 2018: Indian Journal of Endocrinology and Metabolism
Piyush Agarwal, Chhavi Jindal, Vinayak Sapakal
Aims: This study evaluated the efficacy and safety of teneligliptin in patients with inadequately controlled type 2 diabetes mellitus (T2DM). Settings and Design: This was a randomized, doubleblind, placebocontrolled, parallelgroup, multicenter, Phase III study. Subjects and Methods: Patients with T2DM and inadequate glycemic control (glycosylated hemoglobin [HbA1c]: >7.0-≤8.5%) were enrolled. Patients were randomly assigned (ratio: 2:1) to receive teneligliptin 20 mg (Glenmark) or placebo...
January 2018: Indian Journal of Endocrinology and Metabolism
Mohamed Elgendi, Yongbo Liang, Rabab Ward
Photoplethysmogram (PPG) signals collected using a pulse oximeter are increasingly being used for screening and diagnosis purposes. Because of the non-invasive, cost-effective, and easy-to-use nature of the pulse oximeter, clinicians and biomedical engineers are investigating how PPG signals can help in the management of many medical conditions, especially for global health application. The study of PPG signal analysis is relatively new compared to research in electrocardiogram signals, for instance; however, we anticipate that in the near future blood pressure, cardiac output, and other clinical parameters will be measured from wearable devices that collect PPG signals, based on the signal's vast potential...
March 11, 2018: Diseases (Basel)
Joseph Arthur, Kimberson Tanco, Minjeong Park, Ali Haider, Courtney Maligi, Shalini Dalal, Syed M A Naqvi, Diane Liu, Eduardo Bruera
BACKGROUND: There is currently no universally accepted outcome measure in cancer pain management. The personalized pain goal (PPG) has been shown to be a relevant outcome measure. We examined its use in routine outpatient practice and compared it with the clinical important difference (CID, ≥2 points or 30%), a pain outcome measure frequently used in several clinical studies. METHODS: Initial and follow up clinical information of outpatients with advanced cancer pain were retrospectively reviewed...
March 8, 2018: Journal of Pain and Symptom Management
Gloria Pelizzo, Anna Guddo, Aurora Puglisi, Annalisa De Silvestri, Calogero Comparato, Mario Valenza, Emanuele Bordonaro, Valeria Calcaterra
The reliability of wearable photoplethysmography (PPG) sensors to measure heart rate (HR) in hospitalized patients has only been demonstrated in adults. We evaluated the accuracy of HR monitoring with a personal fitness tracker (PFT) in children undergoing surgery. HR monitoring was performed using a wrist-worn PFT (Fitbit Charge HR) in 30 children (8.21 ± 3.09 years) undergoing laparoscopy ( n = 8) or open surgery ( n = 22). HR values were analyzed preoperatively and during surgery. The accuracy of HR recordings was compared with measurements recorded during continuous electrocardiographic (cECG) monitoring; HRs derived from continuous monitoring with pulse oximetry (SpO2R) were used as a positive control...
March 8, 2018: Children
Mohammad Tariqul Islam, Sk Tanvir Ahmed, Ishmam Zabir, Celia Shahnaz, Shaikh Anowarul Fattah
Photoplethysmographic (PPG) signal is getting popularity for monitoring heart rate in wearable devices because of simplicity of construction and low cost of the sensor. The task becomes very difficult due to the presence of various motion artefacts. In this study, an algorithm based on cascade and parallel combination (CPC) of adaptive filters is proposed in order to reduce the effect of motion artefacts. First, preliminary noise reduction is performed by averaging two channel PPG signals. Next in order to reduce the effect of motion artefacts, a cascaded filter structure consisting of three cascaded adaptive filter blocks is developed where three-channel accelerometer signals are used as references to motion artefacts...
February 2018: Healthcare Technology Letters
Baotong Li, Hengchao Wu, Hansong Sun, Jianping Xu, Yunhu Song, Wei Wang, Shuiyun Wang
BACKGROUND: Although it has been realized that restrictive mitral valve annuloplasty (MVA) may result in clinically significant functional mitral stenosis (MS), it still cannot be predicted. The purpose of this study was to identify risk factors for clinically significant functional MS following restrictive MVA surgery for chronic ischemic mitral regurgitation (CIMR). METHODS: 114 patients who underwent restrictive MVA with coronary artery bypass grafting (CABG) for treatment of CIMR were retrospectively reviewed...
March 7, 2018: Cardiology Journal
Bahendeka Silver, Kaushik Ramaiya, Swai Babu Andrew, Otieno Fredrick, Sarita Bajaj, Sanjay Kalra, Bavuma M Charlotte, Karigire Claudine, Anthony Makhoba
A diagnosis of diabetes or hyperglycemia should be confirmed prior to ordering, dispensing, or administering insulin (A). Insulin is the primary treatment in all patients with type 1 diabetes mellitus (T1DM) (A). Typically, patients with T1DM will require initiation with multiple daily injections at the time of diagnosis. This is usually short-acting insulin or rapid-acting insulin analogue given 0 to 15 min before meals together with one or more daily separate injections of intermediate or long-acting insulin...
March 5, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
Ryan Waters, Anna B Ludi, Veronica L Fowler, Ginette Wilsden, Clare Browning, Simon Gubbins, Bob Statham, Abdelghani Bin-Tarif, Valerie Mioulet, David J King, Claire Colenutt, Emma Brown, Pascal Hudelet, Donald P King
In 2015, outbreaks of foot-and-mouth disease (FMD) in the Middle East were discovered to be caused by a viral lineage (A/ASIA/G-VII), which has recently emerged from the Indian sub-continent. In vitro vaccine matching data generated by the World Reference Laboratory (WRLFMD) indicated that A/ASIA/G-VII field viruses were poorly matched with vaccines (A-SAU-95, A22 IRQ and A-IRN-05) that are already used in the region. In order to assess the likely performance of one of these commercially available FMD vaccines, sixteen cattle were vaccinated with a polyvalent vaccine which contained two serotype A components (A-SAU-95 and A-IRN-05) with a homologous potency of at least 6PD50 , and two cattle were left unvaccinated as controls...
March 27, 2018: Vaccine
Makoto Ohara, Hiroe Nagaike, Satoshi Goto, Ayako Fukase, Yuki Tanabe, Masako Tomoyasu, Takeshi Yamamoto, Toshiyuki Hayashi, Tomoyasu Fukui, Tsutomu Hirano
AIMS: We aimed to evaluate which parameters of improvement in glucose metabolism reduce oxidative stress for patients with Type 2 diabetes mellitus (T2DM). METHODS: Sixty-seven outpatients with T2DM underwent 72 h of continuous glucose monitoring (CGM) and were measured for oxidative stress before and after a 24-week intervention with the following targets: fasting plasma glucose (FPG), <130 mg/dl; postprandial plasma glucose (PPG), <180 mg/dl; and glycated hemoglobin (HbA1c), <7% (53 mmol/mol)...
March 1, 2018: Diabetes Research and Clinical Practice
Angela Perucatti, Viviana Genualdo, Alfredo Pauciullo, Ciro Iorio, Domenico Incarnato, Cristina Rossetti, Francesco Vizzarri, Marisa Palazzo, Donato Casamassima, Leopoldo Iannuzzi, Alessandra Iannuzzi
Phenylpropanoid glycosides (PPG), like other phenolic compounds, are a powerful antioxidants and the Verbascoside (VB) is one of the most active of them. A previous study, by using in vitro exposure of blood human lymphocytes to Verbascoside, reported a significant increasings of chromosome fragility compared to control. In the present study, four homogeneous groups of rabbits were used to test in vivo the VB and/or Lycopene (LP) by feeding the animals without VB and LP (control), in presence of VB or/and LP for 80 days...
February 26, 2018: Food and Chemical Toxicology
Xingyu Hou, Xinpeng Jiang, Yanping Jiang, Lijie Tang, Yigang Xu, Xinyuan Qiao, Liu Min, Cui Wen, Guangpeng Ma, Yijing Li
Porcine epidemic diarrhea (PED) is a highly contagious disease in newborn piglets. In our previous study, a genetically engineered Lactobacillus casei oral vaccine ( pPG-COE-DCpep/L393 ) expressing a dendritic cell (DC)-targeting peptide fused with porcine epidemic diarrhea virus (PEDV) COE antigen was developed. This vaccine induced significant levels of anti-PEDV specific IgG and IgA antibody responses in mice, indicating a potential strategy against PEDV infection. In this study, pPG-COE-DCpep/L393 was used for oral vaccination of newborn piglets against PEDV...
March 1, 2018: Viruses
Yuichiro Yamada, Yasuo Terauchi, Hirotaka Watada, Yasuhiko Nakatsuka, Kazuhito Shiosakai, Takuo Washio, Takashi Taguchi
INTRODUCTION: G protein-coupled receptor 119 (GPR119) is a promising target for the treatment of type 2 diabetes mellitus (T2DM), as both insulin and glucagon-like peptide-1 secretion can be promoted with a single drug. We compared the efficacy and safety of the GPR119 agonist DS-8500a with placebo and sitagliptin 50 mg in Japanese patients with T2DM. METHODS: This randomized, double-blind, parallel-group comparison study was conducted in Japan (trial registration NCT02628392, JapicCTI-153068)...
February 27, 2018: Advances in Therapy
Yongbo Liang, Zhencheng Chen, Guiyong Liu, Mohamed Elgendi
Open clinical trial data provide a valuable opportunity for researchers worldwide to assess new hypotheses, validate published results, and collaborate for scientific advances in medical research. Here, we present a health dataset for the non-invasive detection of cardiovascular disease (CVD), containing 657 data segments from 219 subjects. The dataset covers an age range of 20-89 years and records of diseases including hypertension and diabetes. Data acquisition was carried out under the control of standard experimental conditions and specifications...
February 27, 2018: Scientific Data
Vahid Reza Nafisi, Mina Shahabi
BACKGROUND AND OBJECTIVE: One of the most adverse conditions facing the hemodialysis patient is repetitive hypotension during their dialysis session. Different factors can be used to monitor patient conditions and prevent Intradialytic Hypotension (IDH) during hemodialysis. These factors include blood pressure, blood volume, and electrical Impedance factors. In this paper, pre-IDH and IDH episodes were recognized and classified by using the features of the finger photoplethysmography (PPG) signal...
April 2018: Computer Methods and Programs in Biomedicine
Behabitu Ergette Tebikachew, Karl Börjesson, Nina Kann, Kasper Moth-Poulsen
Photocleavable protecting groups (PPGs) offer a complementary protection paradigm compared to traditional protection groups. Herein, o-nitrobenzyl (NB) PPG was employed to protect a variety of arylpropiolic acids. Upon a cascade of light-triggered photodeprotection in a microchannel reactor (residence time 100-500 s), followed by Cu-catalyzed decarboxylation at 60 °C, the NB-protected arylpropiolic acid afforded a terminal alkyne. This terminal alkyne was further reacted in situ with an azide via click chemistry to yield a 1,2,3-triazole in a one-pot reaction...
February 21, 2018: Bioconjugate Chemistry
Sun-Ting Ma, Guo-Jie Ding, Xue-Wei Huang, Zi-Wei Wang, Li Wang, Mei-Ling Yu, Wen Shi, Yan-Ping Jiang, Li-Jie Tang, Yi-Gang Xu, Yi-Jing Li
PURPOSE: Avian colibacillosis is responsible for economic losses to poultry producers worldwide. To combat this, we aimed to develop an effective oral vaccine for chicken against O78 avian pathogenic Escherichia coli (APEC) infection through a Lactobacillus delivery system. METHODOLOGY: Eight Lactobacillus strains isolated from the intestines of broiler chickens were evaluated based on their in vitro adherence ability to assess their potential as a delivery vector...
January 19, 2018: Journal of Medical Microbiology
Rebecca G Fortgang, Rani A Hoff, Marc N Potenza
High rates of both problem and pathological gambling (PPG) and substance-use disorders (SUDs) have been reported in schizophrenia, and yet PPG frequently goes undetected in clinical practice and unexamined in research. Here, we aimed to examine the relationship between PPG and SUDs in a large sample of patients across several factors related to both gambling and substance use, including poly-substance use. Additionally, delay discounting is a form of impulsivity known to positively associate with both PPG and SUDs and thought to underlie mechanisms of addiction in both contexts...
February 16, 2018: Journal of Gambling Studies
Qianli D Y Ma, Changjuan Ji, Huanhuan Xie, Kai Yin, Zhen Ma, Chunhua Bian
The aim of this study is to investigate the coupling behavior between heartbeat and pulse of blood flow at different sleep stages, and to explore the feasibility of using this coupling strength for automatic sleep staging.&#13; Approach: The electrocardiogram (ECG) and photoplethysmography (PPG) signals are recorded during sleep, and R-wave-to-R-wave intervals (RRI) and Pulse-to-Pulse intervals (PPI) are extracted respectively. The detrended cross-correlation analysis (DCCA) is applied to quantify long-range cross correlations between the RRIs and PPIs across sleep stages...
February 16, 2018: Physiological Measurement
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