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https://www.readbyqxmd.com/read/29780322/efficacy-and-safety-of-teneligliptin-in-patients-with-type-2-diabetes-mellitus-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#1
REVIEW
Xiaoxuan Li, Xuefei Huang, Chongfei Bai, Dalian Qin, Shousong Cao, Qibing Mei, Yun Ye, Jianming Wu
Background: Teneligliptin is a 3rd-generation dipeptidyl peptidase-4 (DPP-4) inhibitor. There is a limited evidence regarding the effect of teneligliptin. Therefore, this study is to assess the efficacy and safety of teneligliptin in type 2 diabetes mellitus (T2DM) patients with inadequately glycemic controlled. Methods: A search of PubMed, Medline, Embase, and The Cochrane Library during 2000.01-2018.03 was performed for randomized controlled trials of teneligliptin compared to placebo in patients with T2DM with monotherapy or add-on treatment...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29777849/non-invasive-diagnostic-methods-for-better-screening-of-peripheral-arterial-disease
#2
REVIEW
Neelamshobha Nirala, R Periyasamy, Awanish Kumar
BACKGROUND: Peripheral arterial disease (PAD) is a common circulatory problem in which narrowed arteries reduce blood flow to extremities usually legs. It does not receive enough blood flow to keep up with demand. This causes symptoms, most notably leg pain while walking which is known as claudication. It is a common manifestation of type II Diabetes, but the relationship between other vascular diseases and lower limb (LL)-PAD has been poorly understood and investigated. METHODS: When assessing a patient with clinically LLPAD, two questions are in order to establish a diagnosis: one is non-invasive testing and other is invasive...
May 16, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29775119/effects-of-exercise-in-combination-with-autologous-bone-marrow-stem-cell-transplantation-for-patients-with-type-1-diabetes
#3
Marwa Taher Mohamed, Eman Ahmed Embaby, Awatif Labib, Mohammed El-Husseiny, Hazem Khamis, Ahmed El-Demery, Mohamed Mounir Shoukry
Stem cell therapy is a promising approach for the treatment of type 1 diabetes mellitus (T1D). Previous studies recommended regular exercise for the control of T1D. Experimental studies showed that a combination of stem cells and exercise yielded a better outcome. Yet, the effect of exercise programs following stem cell transplantation in patients with T1D has not been investigated. Thus, the current study aimed to examine the effect of a combined exercise program on measures of glycemic control in patients with T1D who received autologous bone marrow stem cell transplantation (ABMSCT)...
May 18, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29772654/consistency-of-continuous-ambulatory-interstitial-glucose-monitoring-sensors
#4
Pei T Wu, David E Segovia, Cathy C Lee, Kim-Lien Nguyen
AIMS: The abdominal region is the most common location for continuous glucose monitor (CGM) sensor insertion. However, a paucity of post-marketing data is available to demonstrate intra-individual consistency of CGM readings at different abdominal insertion sites. METHODS: Healthy adults (fasting glucose (FG) < 5.5 mmol/L; BMI < 30 kg/m²) were recruited and a CGM sensor was placed on each side of the abdomen. Postprandial and continuous 48-h interstitial glucose levels were analyzed...
May 16, 2018: Biosensors
https://www.readbyqxmd.com/read/29771513/using-3-diethylaminobenzyl-group-deabn-as-a-photocage-in-aqueous-solution
#5
Xiong Ding, Pengfei Wang
We have demonstrated that the 3-diethylaminobenzyl (DEABn) photolabile protecting group (PPG) is an effective and structurally simple PPG for releasing molecules in aqueous environment. In general, the photoreaction is clean, and the released substrate and the PPG product, i.e., 3-diethylaminobenzyl alcohol, are obtained in high yield. The clean photoreaction can also be achieved under mild ambient conditions with sunlight while the reactant is stable under indoor lighting. Release of two substrates from one PPG chromophore in aqueous solution has been demonstrated to be feasible...
May 17, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29764222/comparative-efficacy-of-once-weekly-semaglutide-and-sglt-2-inhibitors-in-type-2-diabetic-patients-inadequately-controlled-with-metformin-monotherapy-a-systematic-literature-review-and-network-meta-analysis
#6
Rohini Sharma, Lars Wilkinson, Hrvoje Vrazic, Evan Popoff, Sandra Lopes, Steve Kanters, Eric Druyts
OBJECTIVE: Treatment intensification with additional antidiabetic agents is recommended in type 2 diabetes (T2D) for patients inadequately controlled on metformin monotherapy. The present network meta-analysis (NMA) evaluated comparative efficacy and safety of once-weekly semaglutide and sodium-glucose co-transporter 2 inhibitors (SGLT-2is) in T2D patients inadequately controlled with metformin. METHODS: Randomized controlled trials with ≥20 weeks duration were searched in EMBASE, MEDLINE, and CENTRAL...
May 15, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29755714/identification-of-cerebral-artery-stenosis-using-bilateral-photoplethysmography
#7
Hyun Goo Kang, Seogki Lee, Han Uk Ryu, Youngsuk Shin
Cerebral artery stenosis is currently diagnosed by transcranial Doppler (TCD), computed tomographic angiography (CTA), or magnetic resonance angiography (MRA). CTA exposes a patient to radiation, while CTA and MRA are invasive and side effects were related to contrast medium use. This study aims to provide a technique that can simply discriminate between people with normal blood vessels and those with cerebral artery stenosis using photoplethysmography (PPG), which is noninvasive and inexpensive. Moreover, the measurement takes only 120 seconds and is conducted on the fingers...
2018: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29751681/biometric-authentication-using-the-ppg-a-long-term-feasibility-study
#8
Jorge Sancho, Álvaro Alesanco, José García
The photoplethysmogram (PPG) is a biomedical signal that can be used to estimate volumetric blood flow changes in the peripheral circulation. During the past few years, several works have been published in order to assess the potential for PPGs to be used in biometric authentication systems, but results are inconclusive. In this paper we perform an analysis of the feasibility of using the PPG as a realistic biometric alternative in the long term. Several feature extractors (based on the time domain and the Karhunen⁻Loève transform) and matching metrics (Manhattan and Euclidean distances) have been tested using four different PPG databases (PRRB, MIMIC-II, Berry, and Nonin)...
May 11, 2018: Sensors
https://www.readbyqxmd.com/read/29750114/profiling-the-propagation-of-error-from-ppg-to-hrv-features-in-a-wearable-physiological-monitoring-device
#9
Davide Morelli, Leonardo Bartoloni, Michele Colombo, David Plans, David A Clifton
Wearable physiological monitors are becoming increasingly commonplace in the consumer domain, but in literature there exists no substantive studies of their performance when measuring the physiology of ambulatory patients. In this Letter, the authors investigate the reliability of the heart-rate (HR) sensor in an exemplar 'wearable' wrist-worn monitoring system (the Microsoft Band 2 ); their experiments quantify the propagation of error from (i) the photoplethysmogram (PPG) acquired by pulse oximetry, to (ii) estimation of HR, and (iii) subsequent calculation of HR variability (HRV) features...
April 2018: Healthcare Technology Letters
https://www.readbyqxmd.com/read/29749570/validation-of-a-photoplethysmography-device-for-detection-of-obstructive-sleep-apnea-in-the-perioperative-setting
#10
Philipp Faßbender, Ali Haddad, Silja Bürgener, Jürgen Peters
Obstructive sleep apnea (OSA) is a risk factor for perioperative complications, but many OSA patients present undiagnosed. While polysomnography (PSG) is the "gold standard" for diagnosis, its application is technology-intense, time-consuming, expensive, and requires specialists, often delaying surgery. Thus, miniaturized devices were developed for OSA screening aimed at ruling out major OSA while measuring a lesser number of biological signals. We evaluated the accuracy of a photoplethysmography (PPG)-based device for OSA detection...
May 10, 2018: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/29745549/-study-on-aided-diagnosis-for-cardiovascular-diseases-based-on-relief-algorithm
#11
Tanqi Zhou, Yongbo Liang, Guiyong Liu, Shaozhen Tan, Zhencheng Chen
The study was intended to introduce a novel method for aided diagnosis of cardiovascular diseases based on photoplethysmography (PPG). For this purpose, 40 volunteers were recruited in this study, of whom the physiological and pathological information was collected, including blood pressure and simultaneous PPG data on fingertips, by using a sphygmomanometer and a smart fingertip sensor. According to the PPG signal and its first and second derivatives, 52 features were defined and acquired. The Relief feature selection algorithm was performed to calculate the contribution of each feature to cardiovascular diseases...
August 1, 2017: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://www.readbyqxmd.com/read/29745496/-pulse-transit-time-detection-based-on-waveform-time-domain-feature-and-dynamic-difference-threshold
#12
Zengding Liu, Ji Chen, Minfang Tang
Aiming at the defects that the traditional pulse transit time (PTT) detection methods are sensitive to changes in photoplethysmography (PPG) signal and require heavy computation, we proposed a new algorithm to detect PTT based on waveform time domain feature and dynamic difference threshold. We calculated the PTT by using dynamic difference threshold method to detect the R-waves of electrocardiogram (ECG), shortening the main peak detection range in PPG signal according to the characteristics of the waveform time domain, and using R wave to detect the main peak of PPG signal...
June 1, 2017: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://www.readbyqxmd.com/read/29723809/global-sensitivity-analysis-of-hepatic-venous-pressure-gradient-hvpg-measurement-with-a-stochastic-computational-model-of-the-hepatic-circulation
#13
Tianqi Wang, Fuyou Liang, Zunqiang Zhou, Xiaolong Qi
Hepatic venous pressure gradient (HVPG) is a widely employed surrogate of portal pressure gradient (PPG) in the diagnosis of portal hypertension (PHT). However, little is known about how HVPG measurement is affected by the complex vascular changes associated with PHT. In this study, we employed a computational method to quantitatively evaluate the sensitivity of HVPG measurement to various vascular factors involved in the development of sinusoidal PHT, aiming to provide a theoretical reference to guide the clinical application of HVPG measurement...
April 25, 2018: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29722189/utility-of-photoplethysmography-for-heart-rate-estimation-among-inpatients
#14
Anoop N Koshy, Jithin K Sajeev, Nitesh Nerlekar, Adam J Brown, Kevin Rajakariar, Mark Zureik, Michael C Wong, Louise Roberts, Maryann Street, Jennifer Cooke, Andrew W Teh
The accuracy of photoplethysmography (PPG) for heart rate (HR) estimation in cardiac arrhythmia is unknown. PPG-HR was evaluated in 112 hospitalised inpatients (cardiac arrhythmias (n = 60), sinus rhythm (n = 52)) using a continuous electrocardiogram monitoring as a reference standard. Strong agreement was observed in sinus rhythm HR < 100 and atrial flutter (bias 1 beat), modest agreement in sinus tachycardia (bias 24 beats) and complete heart block (bias -6 beats) and weak agreement with significant HR underestimation was seen in atrial fibrillation (bias 23 beats)...
May 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29721074/polyamine-targeting-gefitinib-prodrug-and-its-near-infrared-fluorescent-theranostic-derivative-for-monitoring-drug-delivery-and-lung-cancer-therapy
#15
Xinyu Song, Xiaoyue Han, Fabiao Yu, Xiaoyu Zhang, Lingxin Chen, Changjun Lv
The therapy of non-small-cell lung cancer (NSCLC) is challenging because of poor prognosis. There are urgent demands for targeting anti-tumor drugs with reliable efficacy and clear pharmacokinetics. Methods : We designed and synthesized an active tumor-targeting prodrug for the precision therapy of NSCLC. The prodrug polyamine analog Gefitinib (PPG) was derived from the conjugation between a tumor-targeting ligand polyamine analog (PA) and an epidermal growth factor receptor tyrosine kinase inhibitor Gefitinib via a cleavable disulfide linker...
2018: Theranostics
https://www.readbyqxmd.com/read/29714722/an-optimal-filter-for-short-photoplethysmogram-signals
#16
Yongbo Liang, Mohamed Elgendi, Zhencheng Chen, Rabab Ward
A photoplethysmogram (PPG) contains a wealth of cardiovascular system information, and with the development of wearable technology, it has become the basic technique for evaluating cardiovascular health and detecting diseases. However, due to the varying environments in which wearable devices are used and, consequently, their varying susceptibility to noise interference, effective processing of PPG signals is challenging. Thus, the aim of this study was to determine the optimal filter and filter order to be used for PPG signal processing to make the systolic and diastolic waves more salient in the filtered PPG signal using the skewness quality index...
May 1, 2018: Scientific Data
https://www.readbyqxmd.com/read/29710853/comparison-of-the-hepatoprotective-effects-of-four-endemic-cirsium-species-extracts-from-taiwan-on-ccl%C3%A2-induced-acute-liver-damage-in-c57bl-6-mice
#17
Zi-Wei Zhao, Jen-Chih Chang, Li-Wei Lin, Fan-Hsuan Tsai, Hung-Chi Chang, Chi-Rei Wu
Species of Cirsium (Asteraceae family) have been used in folk hepatoprotective medicine in Taiwan. We collected four Cirsium species&mdash;including the aerial part of Cirsium arisanense (CAH), the aerial part of Cirsium kawakamii (CKH), the flower part of Cirsium japonicum DC. var. australe (CJF), and Cirsii Herba (CH)&mdash;and then made extractions from them with 70% methanol. We compared the antioxidant contents and activities of these four Cirsium species extracts by a spectrophotometric method and high-performance liquid chromatography⁻photodiode array detector (HPLC-DAD)...
April 30, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29707186/a-novel-neural-network-model-for-blood-pressure-estimation-using-photoplethesmography-without-electrocardiogram
#18
Ludi Wang, Wei Zhou, Ying Xing, Xiaoguang Zhou
The prevention, evaluation, and treatment of hypertension have attracted increasing attention in recent years. As photoplethysmography (PPG) technology has been widely applied to wearable sensors, the noninvasive estimation of blood pressure (BP) using the PPG method has received considerable interest. In this paper, a method for estimating systolic and diastolic BP based only on a PPG signal is developed. The multitaper method (MTM) is used for feature extraction, and an artificial neural network (ANN) is used for estimation...
2018: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29704614/contribution-of-systemic-vascular-effects-to-fmri-activity-in-white-matter
#19
Pinar S Özbay, Catie Chang, Dante Picchioni, Hendrik Mandelkow, Thomas M Moehlman, Miranda G Chappel-Farley, Peter van Gelderen, Jacco A de Zwart, Jeff H Duyn
To investigate a potential contribution of systemic physiology to recently reported BOLD fMRI signals in white matter, we compared photo-plethysmography (PPG) and whole-brain fMRI signals recorded simultaneously during long resting-state scans from an overnight sleep study. We found that intermittent drops in the amplitude of the PPG signal exhibited strong and widespread correlations with the fMRI signal, both in white matter (WM) and in gray matter (GM). The WM signal pattern resembled that seen in previous resting-state fMRI studies and closely tracked the location of medullary veins...
April 25, 2018: NeuroImage
https://www.readbyqxmd.com/read/29696567/factors-influencing-the-prescribing-preferences-of-physicians-for-drug-naive-patients-with-type-2-diabetes-mellitus-in-the-real-world-setting-in-japan-insight-from-a-web-survey
#20
Hiroki Murayama, Kota Imai, Masato Odawara
INTRODUCTION: The Japanese guidelines for type 2 diabetes mellitus (T2DM) emphasize individualization of treatment based on patient need and encourage physicians to select an appropriate oral antidiabetes drug (OAD). However, limited evidence is available on the factors influencing the selection by physicians (diabetes specialists and nonspecialists) of the first-line OAD to treat drug-naive patients with T2DM. A survey was designed to explore the treatment factors and patient characteristics that influence physicians when they choose an initial OAD to prescribe to a drug-naive patient with T2DM in a real-world setting in Japan...
April 25, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
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