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https://www.readbyqxmd.com/read/28806084/photochemical-activation-of-tertiary-amines-for-applications-in-studying-cell-physiology
#1
Naeem Asad, Davide Deodato, Xin Lan, Magnus B Widegren, David Lee Phillips, Lili Du, Timothy M Dore
Representative tertiary amines were linked to the 8-cyano-7-hydroxyquinolinyl (CyHQ) photoremovable protecting group (PPG) to create photoactivatable forms suitable for use in studying cell physiology. The photoactivation of tamoxifen and 4-hydroxytamoxifen, which can be used to activate Cre recombinase and CRISPR-Cas9 gene editing, demonstrated that highly efficient release of bioactive molecules could be achieved through 1- and 2-photon excitation (1PE and 2PE). CyHQ-protected anilines underwent a photo-aza-Claisen rearrangement instead of releasing amines...
August 14, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28805751/characterization-of-quadratic-nonlinearity-between-motion-artifact-and-acceleration-data-and-its-application-to-heartbeat-rate-estimation
#2
Sunho Kim, Sungbin Im, Taehyung Park
Accelerometers are applied to various applications to collect information about movements of other sensors deployed at diverse fields ranging from underwater area to human body. In this study, we try to characterize the nonlinear relationship between motion artifact and acceleration data. The cross bicoherence test and the Volterra filter are used as the approaches to detection and modeling. We use the cross bicoherence test to directly detect in the frequency domain and we indirectly identify the nonlinear relationship by improving the performance of eliminating motion artifact in heartbeat rate estimation using a nonlinear filter, the second-order Volterra filter...
August 14, 2017: Sensors
https://www.readbyqxmd.com/read/28803197/sources-and-accumulation-of-plutonium-in-a-large-western-pacific-marginal-sea-the-south-china-sea
#3
Junwen Wu, Minhan Dai, Yi Xu, Jian Zheng
In order to examine the sources of plutonium (Pu) and elaborate its scavenging and accumulation processes, (240)Pu/(239)Pu atom ratios and (239+240)Pu activities in the water column of the South China Sea (SCS) were determined and compared with our previously reported data for the sediments. Consistently high (240)Pu/(239)Pu atom ratios that ranged from 0.184-0.250 (average=0.228±0.015), indicative of non-global fallout Pu sources were observed both in the surface water and at depth during 2012-2014. The spatial distribution of the (240)Pu/(239)Pu atom ratio in the SCS showed a decreasing trend away from the Luzon Strait, which was very consistent with the introduction pathway of the Kuroshio Current...
August 10, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28792171/glycemic-pentad
#4
Glycemic Pentad Forum
BACKGROUND: Conventionally, diabetes management involved targeting the triad of FPG, PPG, and HbA1c. However, several studies have suggested the quintessential need for a paradigm shift to incorporate glycemic variability and quality of life in the holistic diabetes control regimen. AIM: To generate a consensus and ratify the position of Glycemic Variability (GV) and Quality of Life (QOL), along with the traditional triad, in diabetes management in India. To evaluate whether the triple fixed dose combination of metformin, glimepiride, and voglibose can accomplish the goals of glycemic pentad...
July 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28789685/remote-monitoring-of-cardiorespiratory-signals-from-a-hovering-unmanned-aerial-vehicle
#5
Ali Al-Naji, Asanka G Perera, Javaan Chahl
BACKGROUND: Remote physiological measurement might be very useful for biomedical diagnostics and monitoring. This study presents an efficient method for remotely measuring heart rate and respiratory rate from video captured by a hovering unmanned aerial vehicle (UVA). The proposed method estimates heart rate and respiratory rate based on the acquired signals obtained from video-photoplethysmography that are synchronous with cardiorespiratory activity. METHODS: Since the PPG signal is highly affected by the noise variations (illumination variations, subject's motions and camera movement), we have used advanced signal processing techniques, including complete ensemble empirical mode decomposition with adaptive noise (CEEMDAN) and canonical correlation analysis (CCA) to remove noise under these assumptions...
August 8, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28769817/suicidal-ideation-is-associated-with-altered-variability-of-fingertip-photo-plethysmogram-signal-in-depressed-patients
#6
Ahsan H Khandoker, Veena Luthra, Yousef Abouallaban, Simanto Saha, Khawza I U Ahmed, Raqibul Mostafa, Nayeefa Chowdhury, Herbert F Jelinek
Physiological and psychological underpinnings of suicidal behavior remain ill-defined and lessen timely diagnostic identification of this subgroup of patients. Arterial stiffness is associated with autonomic dysregulation and may be linked to major depressive disorder (MDD). The aim of this study was to investigate the association between arterial stiffness by photo-plethysmogram (PPG) in MDD with and without suicidal ideation (SI) by applying multiscale tone entropy (T-E) variability analysis. Sixty-one 10-min PPG recordings were analyzed from 29 control, 16 MDD patients with (MDDSI+) and 16 patients without SI (MDDSI-)...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28767091/heart-rate-detection-using-microsoft-kinect-validation-and-comparison-to-wearable-devices
#7
Ennio Gambi, Angela Agostinelli, Alberto Belli, Laura Burattini, Enea Cippitelli, Sandro Fioretti, Paola Pierleoni, Manola Ricciuti, Agnese Sbrollini, Susanna Spinsante
Contactless detection is one of the new frontiers of technological innovation in the field of healthcare, enabling unobtrusive measurements of biomedical parameters. Compared to conventional methods for Heart Rate (HR) detection that employ expensive and/or uncomfortable devices, such as the Electrocardiograph (ECG) or pulse oximeter, contactless HR detection offers fast and continuous monitoring of heart activities and provides support for clinical analysis without the need for the user to wear a device. This paper presents a validation study for a contactless HR estimation method exploiting RGB (Red, Green, Blue) data from a Microsoft Kinect v2 device...
August 2, 2017: Sensors
https://www.readbyqxmd.com/read/28764219/teneligliptin-in-early-diabetic-kidney-disease-an-observation-in-asian-indian-patients-with-type-2-diabetes-mellitus-in-real-life-scenario
#8
Kiran Shah
INTRODUCTION: Teneligliptin is a recently developed Dipeptidyl Peptidase 4 (DPP4) inhibitor. Teneligliptin is suitable for glycaemic control with renal impairment including end stage renal disease. AIM: To assess the efficacy and safety of teneligliptin in Asian Indian patients of Type 2 Diabetes Mellitus (T2DM) with early Diabetic Kidney Disease (DKD). MATERIALS AND METHODS: This was a single centre, retrospective analysis of patients with early DKD, who received teneligliptin 20 mg once daily for 24 weeks...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28759735/the-effect-of-dairy-products-consumed-with-high-glycemic-carbohydrate-on-subjective-appetite-food-intake-and-post-prandial-glycemia-in-older-adults
#9
Marron Law, Ying Ti Lee, Shirley Vien, Bohdan L Luhovyy, G Harvey Anderson
OBJECTIVE: To compare the effect of liquid, semi-solid and solid dairy products and a non-dairy beverage when consumed with glycemic carbohydrate on subjective appetite, food intake (FI) and post-prandial glycemia (PPG) in healthy older adults. DESIGN: Thirty healthy men and women (14 males and 16 females; age: 64.6 + 2.4 y; BMI: 25.6 + 2.5 kg/m2) participated in a randomized crossover study. Treatments were one of 250 mL of 2% fat milk and soy beverage, 175 g of 2% Greek yogurt and 30 g of Cheddar cheese consumed as part of an isocaloric (380 kcal) meal with bread and jam...
July 31, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28759734/the-effect-of-dairy-and-non-dairy-beverages-consumed-with-high-glycemic-cereal-on-subjective-appetite-food-intake-and-post-prandial-glycemia-in-young-adults
#10
Marron Law, Pedro S P Huot, Ying Ti Lee, Shirley Vien, Bohdan L Luhovyy, G Harvey Anderson
OBJECTIVE: To compare the effect of dairy and non-dairy beverages when consumed with carbohydrate at breakfast on subjective appetite, food intake (FI) and post-prandial glycemia (PPG) in healthy young adults. DESIGN: Twenty-six healthy males and females (13 males and 13 females; 23.0 + 2.6 years; BMI: 22.3 + 1.5 kg/m2) participated in a randomized crossover study. They consumed non-isocaloric amounts (250 mL) of almond beverage, soy beverage, 1% fat milk, yogurt beverage and water (control) with cereal and 120 min later, an ad libitum meal...
July 31, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28752054/serotonergic-modulation-of-the-activity-of-glp-1-producing-neurons-in-the-nucleus-of-the-solitary-tract-in-mouse
#11
Marie K Holt, Ida J Llewellyn-Smith, Frank Reimann, Fiona M Gribble, Stefan Trapp
OBJECTIVE: Glucagon-like peptide-1 (GLP-1) and 5-HT are potent regulators of food intake within the brain. GLP-1 is expressed by preproglucagon (PPG) neurons in the nucleus tractus solitarius (NTS). We have previously shown that PPG neurons innervate 5-HT neurons in the ventral brainstem. Here, we investigate whether PPG neurons receive serotonergic input and respond to 5-HT. METHODS: We employed immunohistochemistry to reveal serotonergic innervation of PPG neurons...
August 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/28742225/the-efficacy-and-safety-of-lixisenatide-in-a-predominantly-asian-population-with-type-2-diabetes-insufficiently-controlled-with-basal-insulin-the-getgoal-l-c-randomized-trial
#12
W Yang, K Min, Z Zhou, L Li, X Xu, D Zhu, A Venkateshwar Rao, L S Murthy, N Zhang, I Li, E Niemoeller, S Shang
AIMS: To assess the effects on glycaemic control of lixisenatide versus placebo as add-on treatment to basal insulin (BI) ± metformin on glycated haemoglobin (HbA1c) reduction in patients with insufficiently controlled type 2 diabetes (T2D). METHODS: Patients (n = 448) with inadequately controlled T2D were randomized (1:1) to lixisenatide or placebo as add-on to BI ± metformin for 24 weeks after an 8-week run-in phase, during which BI was titrated to a target self-monitored plasma glucose (SMPG; 4...
July 25, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28738763/an-evaluation-of-the-clinical-therapeutic-effect-of-lixisenatide-in-type-2-diabetes-patients-a-systematic-literature-review
#13
Arinze Nkemdirim Okere, Janele Montesdeoca, April Glasper, Vakaramoko Diaby
BACKGROUND: With cardiovascular disease accounting for approximately 50% of deaths in patients diagnosed with type 2 diabetes, it is pertinent to initiate anti-diabetic medications with cardiovascular benefits. This systematic clinical review critically examines the clinical therapeutic effect of lixisenatide. METHODS: Data were gathered from articles indexed in PubMed, Google Scholar and Medline from 2010 - 2017, with the following search terms, "lixisenatide" and "GLP-1 receptor agonist...
July 24, 2017: Current Diabetes Reviews
https://www.readbyqxmd.com/read/28708112/a-pulse-rate-detection-method-for-mouse-application-based-on-multi-ppg-sensors
#14
Shu-Tyng Lin, Wei-Hao Chen, Yuan-Hsiang Lin
Heart rate is an important physiological parameter for healthcare. Among measurement methods, photoplethysmography (PPG) is an easy and convenient method for pulse rate detection. However, as the PPG signal faces the challenge of motion artifacts and is constrained by the position chosen, the purpose of this paper is to implement a comfortable and easy-to-use multi-PPG sensor module combined with a stable and accurate real-time pulse rate detection method on a computer mouse. A weighted average method for multi-PPG sensors is used to adjust the weight of each signal channel in order to raise the accuracy and stability of the detected signal, therefore reducing the disturbance of noise under the environment of moving effectively and efficiently...
July 14, 2017: Sensors
https://www.readbyqxmd.com/read/28705807/augmentation-of-cgmp-pkg-pathway-and-colonic-motility-by-hydrogen-sulfide
#15
Ancy D Nalli, Sayak Bhattacharya, Hongxia Wang, Derek M Kendig, John R Grider, Karnam S Murthy
Hydrogen sulfide (H2S), like nitric oxide (NO), causes smooth muscle relaxation, but unlike NO, does not stimulate soluble guanylyl cyclase (sGC) activity and generate cGMP. The aim of this study was to investigate the interplay between NO and H2S in colonic smooth muscle. In colonic smooth muscle from rabbit, mouse and human, L-cysteine, substrate of cystathionine-γ-lyase (CSE), or NaHS, an H2S donor, inhibited phosphodiesterase 5 (PDE5) activity and augmented the increase in cGMP levels, IP3 receptor phosphorylation at Ser(1756) (measured as a proxy for PKG activation), and muscle relaxation in response to NO donor, s-nitrosoglutathione (GSNO), suggesting augmentation of cGMP/PKG pathway by H2S...
July 13, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/28701038/micellear-gold-nanoparticles-as-delivery-vehicles-for-dual-tyrosine-kinase-inhibitor-zd6474-for-metastatic-breast-cancer-treatment
#16
Siddik Sarkar, Suraj Konar, Puvvada Naga Prasad, Shashi Rajput, B N Prashanth Kumar, Raj R Rao, Amita Pathak, Paul B Fisher, Mahitosh Mandal
The therapeutic index of poorly water-soluble drugs is often hampered due to poor pharmacokinetics, reduced blood retention, and lack of effective drug concentrations in the tumor region. In order to overcome these issues, drugs are often delivered by use of delivery vehicles to provide an enhanced therapeutic index. Gold nanoparticles synthesized in micellar networks of amphiphilic block copolymer (AuNM) provide an efficient nanocarrier for tissue- and site-specific drug delivery owing to their low cytotoxicity and immunogenicity...
July 28, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28685995/meta-analysis-and-critical-review-on-the-efficacy-and-safety-of-alpha-glucosidase-inhibitors-in-asian-and-non-asian-populations
#17
Xueying Gao, Xiaoling Cai, Wenjia Yang, Yifei Chen, Xueyao Han, Linong Ji
AIMS: To evaluate the efficacy and safety of alpha glucosidase inhibitors (AGI) in Asian and non-Asian type 2 diabetic patients. MATERIALS AND METHODS: Studies were identified through a literature search of MEDLINE, EMBASE, and other databases until December 2016. All statistical analyses were conducted in Review Manager statistical software by computing the weighted mean difference (WMD) or odds ratio (OR) and 95% confidence interval (CI). RESULTS: A total of 67 studies were included...
July 7, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28680722/botulinum-toxin-injection-for-the-treatment-of-delayed-gastric-emptying-following-pylorus-preserving-gastrectomy-an-initial-experience
#18
Jung Hwan Lee, Chan Gyoo Kim, Young-Woo Kim, Il Ju Choi, Jong Yeul Lee, Soo-Jeong Cho, Young-Il Kim, Bang Wool Eom, Hong Man Yoon, Keun Won Ryu
PURPOSE: To report our experience of endoscopic botulinum toxin injection in patients who experienced severe delayed gastric emptying after pylorus-preserving gastrectomy (PPG). MATERIALS AND METHODS: We reviewed the medical records of 6 patients who received the botulinum toxin injection. They presented with severe delayed gastric emptying in the early postoperative period. Endoscopic botulinum toxin was administered as 4 injections of 25-50 IU into each of the 4 quadrants of the prepyloric area...
June 2017: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/28675070/validity-of-heart-rate-measurements-by-the-garmin-forerunner-225-at-different-walking-intensities
#19
Jomme Claes, Roselien Buys, Andrea Avila, Dewar Finlay, Alan Kennedy, Daniel Guldenring, Werner Budts, Véronique Cornelissen
The accuracy of wrist worn heart rate monitors based on photoplethysmography (PPG) is not fully clinically accepted. Therefore, we aimed to validate heart rate measurements of a commercially available PPG heart rate monitor, i.e. the Garmin Forerunner(®) 225. Twelve healthy volunteers (six women; mean age: 28 years) performed a treadmill protocol consisting of: five minutes sitting, five minutes standing, 10 minutes walking at 4 km/h, 10 minutes walking at a gradient of 5% and intensity of 4-6 metabolic equivalents (METs), 10 minutes walking at a gradient of 8% and intensity of seven METs or more...
July 4, 2017: Journal of Medical Engineering & Technology
https://www.readbyqxmd.com/read/28671576/hybrid-optical-unobtrusive-blood-pressure-measurements
#20
Guangfei Zhang, Caifeng Shan, Ihor Kirenko, Xi Long, Ronald M Aarts
Blood pressure (BP) is critical in diagnosing certain cardiovascular diseases such as hypertension. Some previous studies have proved that BP can be estimated by pulse transit time (PTT) calculated by a pair of photoplethysmography (PPG) signals at two body sites. Currently, contact PPG (cPPG) and imaging PPG (iPPG) are two feasible ways to obtain PPG signals. In this study, we proposed a hybrid system (called the ICPPG system) employing both methods that can be implemented on a wearable device, facilitating the measurement of BP in an inconspicuous way...
July 1, 2017: Sensors
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