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Yue Feng, Moyang Lv, YuQin Lu, Ke Liu, Lizhong Liu, Zhendan He, Kaimin Wu, Xinrong Wang, Baoshuang Zhang, Xuli Wu
Phenylpropanoid glycosides (PPGs) are important bioactive polyphenolic compounds that are widely distributed in plants. In this paper, the inhibitory effects of four selected PPGs against trypsin were investigated. The interactions between these PPGs and trypsin were further investigated by multiple spectroscopic methods and molecular docking studies. The results showed that the binding of each of these PPGs to trypsin induced changes in the natural conformation of trypsin, which inhibited the enzyme in the following order: acteoside>syringalide A 3'-α-l-rhamnopyranoside>lipedoside A-I>osmanthuside B...
March 15, 2018: Food Chemistry
Tao Wang, Wei Sun, Xingyuan Zhang, Haiyan Xu, Fei Xu
Colored waterborne polyurethanes have been widely used in paintings, leathers, textiles, and coatings. Here, a series of black waterborne polyurethanes (WPUs) with different ratios of black dye, Sudan Black B (SDB), were prepared by step-growth polymerization. WPU emulsions as obtained exhibit low particle sizes and remarkable storage stability at the same time. At different dye loadings, essential structural, statistical and thermal properties are characterized. FTIR (fourier transform infrared) spectra indicate that SDB is covalently linked into waterborne polyurethane chains...
October 28, 2017: Materials
Tuğba Aydogan, BetÜl İlkay Sezgin Akçay, Esra Kardeş, Ahmet Ergin
PURPOSE: The objective of this study is to evaluate the diagnostic ability of retinal nerve fiber layer (RNFL), macular, optic nerve head (ONH) parameters in healthy subjects, ocular hypertension (OHT), preperimetric glaucoma (PPG), and early glaucoma (EG) patients, to reveal factors affecting the diagnostic ability of spectral domain-optical coherence tomography (SD-OCT) parameters and risk factors for glaucoma. METHODS: Three hundred and twenty-six eyes (89 healthy, 77 OHT, 94 PPG, and 66 EG eyes) were analyzed...
November 2017: Indian Journal of Ophthalmology
James S Rosenblum, E Michael Thurman, Imma Ferrer, George R Aiken, Karl G Linden
A long-term field study (405 days) of a hydraulically fractured well from the Niobrara Formation in the Denver-Julesburg Basin was completed. Characterization of organic chemicals used in hydraulic fracturing and their changes through time, from the pre-injected fracturing fluid to the produced water, was conducted. The characterization consisted of a mass balance by dissolved organic carbon (DOC), volatile organic analysis by gas chromatography/mass spectrometry, and nonvolatile organic analysis by liquid chromatography/mass spectrometry...
November 14, 2017: Environmental Science & Technology
Prashant Koshal, Sumit Jamwal, Puneet Kumar
Epilepsy is one of the most prevalent neurological disorder affecting more than 50 million people worldwide. Numerous studies have suggested that an imbalance in glutamatergic (excitatory) and GABAergic (inhibitory) neurotransmitter system is one of the dominating pathophysiological mechanisms underlying the occurrence and progression of seizures. Further, this alteration in GABAergic and glutamatergic system disrupts the delicate balance of other neurotransmitters system in the brain. Emerging strides have documented the protective role of GLP-1 signaling on altered neurotransmitters signaling in Epilepsy and associated co-morbidities...
November 9, 2017: Neuropharmacology
Paul S Addison, Dominique Jacquel, David M H Foo, Ulf R Borg
The robust monitoring of heart rate from the video-photoplethysmogram (video-PPG) during challenging conditions requires new analysis techniques. The work reported here extends current research in this area by applying a motion tolerant algorithm to extract high quality video-PPGs from a cohort of subjects undergoing marked heart rate changes during a hypoxic challenge, and exhibiting a full range of skin pigmentation types. High uptimes in reported video-based heart rate (HRvid) were targeted, while retaining high accuracy in the results...
November 9, 2017: Journal of Clinical Monitoring and Computing
Shawn Marschall-Lévesque, Joanne-Lucine Rouleau, Patrice Renaud
Penile plethysmography (PPG) is a measure of sexual interests that relies heavily on the stimuli it uses to generate valid results. Ethical considerations surrounding the use of real images in PPG have further limited the content admissible for these stimuli. To palliate this limitation, the current study aimed to combine audio and visual stimuli by incorporating computer-generated characters to create new stimuli capable of accurately classifying sex offenders with child victims, while also increasing the number of valid profiles...
November 8, 2017: Archives of Sexual Behavior
Hanny M Boers, Theo H van Dijk, Harry Hiemstra, Anne-Roos Hoogenraad, David J Mela, Harry P F Peters, Roel J Vonk, Marion G Priebe
We previously found that guar gum (GG) and chickpea flour (CPF) added to flatbread wheat flour lowered postprandial blood glucose (PPG) and insulin responses dose dependently. However, rates of glucose influx cannot be determined from PPG, which integrates rates of influx, tissue disposal and hepatic glucose production. The objective was to quantify rates of glucose influx and related fluxes as contributors to changes in PPG with GG and CPF additions to wheat-based flatbreads. In a randomised cross-over design, twelve healthy males consumed each of three different 13C-enriched meals: control flatbreads (C), or C incorporating 15 % CPF with either 2 % (GG2) or 4 % (GG4) GG...
November 7, 2017: British Journal of Nutrition
Farzad Mirabbasi, Abolghasem Moghimi, Shadab Shahsavari, Niloofar Babanejad, Simin Seifirad, Farid Dorkoosh
BACKGROUND: Chitosan nanoparticles have the potential to be used as hydrophilic carrier systems since they can deliver drugs to specific sites and control the drug release rate. Moreover, control released systems are designed to minimize systemic absorption and to achieve optimum delivery of the biologically active mesalamine to the distal small intestine and the colon. OBJECTIVE: The current study investigated the development of new nanoparticulate drug delivery systems based on polyurethane-chitosan copolymers...
November 3, 2017: Pharmaceutical Nanotechnology
Kexin Zhang, Shaoming Pan, Zhiyong Liu, Guosheng Li, Yihong Xu, Yongpei Hao
Activity concentration of plutonium (Pu) and its isotopic compositions are extensively used for measuring transport processes of Pu and identifying its source. We investigated the spatial distribution characteristics of (239+240)Pu activity concentrations and (240)Pu/(239)Pu atom ratio in several sediment cores collected from the Liao River coastal zone. Additionally, we calculated the (239+240)Pu inventories and based on the (240)Pu/(239)Pu atom ratio to trace Pu source. The activity concentrations of (239+240)Pu in surface sediments of the Liao River estuary ranged between 0...
November 3, 2017: Journal of Environmental Radioactivity
Xuemei Shi, Shaji Chacko, Feng Li, Depei Li, Douglas Burrin, Lawrence Chan, Xinfu Guan
OBJECTIVE: Glucagon-like peptides are co-released from enteroendocrine L cells in the gut and preproglucagon (PPG) neurons in the brainstem. PPG-derived GLP-1/2 are probably key neuroendocrine signals for the control of energy balance and glucose homeostasis. The objective of this study was to determine whether activation of PPG neurons per se modulates glucose homeostasis and insulin sensitivity in vivo. METHODS: We generated glucagon (Gcg) promoter-driven Cre transgenic mice and injected excitatory hM3Dq-mCherry AAV into their brainstem NTS...
November 2017: Molecular Metabolism
Feiyi Fan, Yuepeng Yan, Yongzhong Tang, Hao Zhang
Monitoring pulse oxygen saturation (SpO2) and heart rate (HR) using photoplethysmography (PPG) signal contaminated by a motion artifact (MA) remains a difficult problem, especially when the oximeter is not equipped with a 3-axis accelerometer for adaptive noise cancellation. In this paper, we report a pioneering investigation on the impact of altering the frame length of Molgedey and Schuster independent component analysis (ICAMS) on performance, design a multi-classifier fusion strategy for selecting the PPG correlated signal component, and propose a novel approach to extract SpO2 and HR readings from PPG signal contaminated by strong MA interference...
November 2, 2017: Computers in Biology and Medicine
Silvia Ronzitti, Shane W Kraus, Rani A Hoff, Marc N Potenza
The purpose of this study was to examine the extent to which stress moderated the relationships between problem-gambling severity and psychopathologies. We analyzed Wave-1 data from 41,869 participants of the National Epidemiologic Survey of Alcohol and Related Conditions (NESARC). Logistic regression showed that as compared to a non-gambling (NG) group, individuals at-risk gambling (ARG) and problem gambling (PPG) demonstrated higher odds of multiple Axis-I and Axis-II disorders in both high- and low-stress groups...
October 22, 2017: Psychiatry Research
Youngjun Cho, Simon J Julier, Nicolai Marquardt, Nadia Bianchi-Berthouze
The ability to monitor the respiratory rate, one of the vital signs, is extremely important for the medical treatment, healthcare and fitness sectors. In many situations, mobile methods, which allow users to undertake everyday activities, are required. However, current monitoring systems can be obtrusive, requiring users to wear respiration belts or nasal probes. Alternatively, contactless digital image sensor based remote-photoplethysmography (PPG) can be used. However, remote PPG requires an ambient source of light, and does not work properly in dark places or under varying lighting conditions...
October 1, 2017: Biomedical Optics Express
Chan-Sol Hwang, Sung-Pyo Yang, Kyung-Won Jang, Jung-Woo Park, Ki-Hun Jeong
We report an angle-selective optical filter (ASOF) for highly sensitive reflection photoplethysmography (PPG) sensors. The ASOF features slanted aluminum (Al) micromirror arrays embedded in transparent polymer resin, which effectively block scattered light under human tissue. The device microfabrication was done by using geometry-guided resist reflow of polymer micropatterns, polydimethylsiloxane replica molding, and oblique angle deposition of thin Al film. The angular transmittance through the ASOF is precisely controlled by the angle of micromirrors...
October 1, 2017: Biomedical Optics Express
Jiajia Song, Dan Li, Xiaoyuan Ma, Guowei Teng, Jianming Wei
Dynamic accurate heart-rate (HR) estimation using a photoplethysmogram (PPG) during intense physical activities is always challenging due to corruption by motion artifacts (MAs). It is difficult to reconstruct a clean signal and extract HR from contaminated PPG. This paper proposes a robust HR-estimation algorithm framework that uses one-channel PPG and tri-axis acceleration data to reconstruct the PPG and calculate the HR based on features of the PPG and spectral analysis. Firstly, the signal is judged by the presence of MAs...
October 25, 2017: Sensors
Dongrae Cho, Jinsil Ham, Jooyoung Oh, Jeanho Park, Sayup Kim, Nak-Kyu Lee, Boreom Lee
Virtual reality (VR) is a computer technique that creates an artificial environment composed of realistic images, sounds, and other sensations. Many researchers have used VR devices to generate various stimuli, and have utilized them to perform experiments or to provide treatment. In this study, the participants performed mental tasks using a VR device while physiological signals were measured: a photoplethysmogram (PPG), electrodermal activity (EDA), and skin temperature (SKT). In general, stress is an important factor that can influence the autonomic nervous system (ANS)...
October 24, 2017: Sensors
Hyungseup Kim, Yunjong Park, Youngwoon Ko, Yeongjin Mun, Sangmin Lee, Hyoungho Ko
BACKGROUND: Wearable healthcare systems require measurements from electrocardiograms (ECGs) and photoplethysmograms (PPGs), and the blood pressure of the user. The pulse transit time (PTT) can be calculated by measuring the ECG and PPG simultaneously. Continuous-time blood pressure without using an air cuff can be estimated by using the PTT. OBJECTIVE: This paper presents a biosignal acquisition integrated circuit (IC) that can simultaneously measure the ECG and PPG for wearable healthcare applications...
October 13, 2017: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
Changmok Choi, Byung-Hoon Ko, Jongwook Lee, Seung Keun Yoon, Uikun Kwon, Sang Joon Kim, Younho Kim
This paper describes photoplethysmography (PPG)-based pulse direction determination algorithm on a site of the radial artery using a wrist band. It has been well known that PPG is susceptible to noise and motion artifacts in the mobile environment and many research efforts have been made to focus on rejection of the noise and motion artifacts. However, no research has been performed to find PPG pulses when PPG is inverted by wrist movement. We present an algorithm, which accurately yields which direction PPG pulses face regardless of wrist movement...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Timo Tigges, Alexandru Pielmus, Michael Klum, Aarne Feldheiser, Oliver Hunsicker, Reinhold Orglmeister
In the analysis of fingertip photoplethysmograms (PPG), the Pulse Decomposition Analysis (PDA) has emerged as a powerful tool for the extraction of physiologically relevant information from the morphology of single digital volume pulse (DVP) cycles. In previously published works on the PDA, many different models are suggested. In this work, we conducted a data driven approach to address the question of which model to choose for the PDA. For this purpose, we compiled an extensive dataset of 7805 single DVP pulses that comprises most expectable pulse morphologies and conducted PDA simulations with four different basis functions types and a meaningful range of model orders...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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