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https://www.readbyqxmd.com/read/28088960/-role-and-mechanism-of-hydrogen-sulfide-in-cigarette-smoke-induced-chronic-obstructive-pulmonary-disease-related-pulmonary-vascular-remodeling-in-rats
#1
M X Li, Y H Chen, C C Liao, F Lin, Y Bai, W J Mi, Y Sun, Y F Qi
Objective: To investigate the role and mechanism of hydrogen sulfide (H2S) in rats with chronic obstructive pulmonary disease (COPD) related pulmonary vascular remodeling. Methods: Twenty four healthy male Sprague-Dawley rats were randomly divided into 4 groups: control group, cigarette smoke (CS) group, CS+ Sodium hydrosulfide (NaHS) group and CS+ DL-propargylglycine (PPG) group. Rats in control group were fed normally and breathed clear air, and for the rest groups, passive cigarette smoke inhalation method were adopted to establish COPD model...
January 10, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28087908/-berberine-regulates-glycemia-via-local-inhibition-of-intestinal-dipeptidyl-peptidase-%C3%A2
#2
Jiesheng Wang, Guanhai Dai, Weijia Li
Objective: To investigate the effect of berberine on glycemia regulation in rats with diabetes and the related mechanisms. Methods: Diabetic-like rat model was successfully induced by intraperitoneal injection of streptozotocin in 50 out of 60 male SD rats, which were then randomly divided into 5 groups with 10 rats in each:control group (received vehicle only), positive drug control group (sitagliptin 10 mg·kg(-1)·d(-1)), low-dose berberine group (30 mg·kg(-1)·d(-1)), moderate-dose berberine group (60 mg·kg(-1)·d(-1)), and high-dose berberine group (120 mg·kg(-1)·d(-1))...
May 25, 2016: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
https://www.readbyqxmd.com/read/28086939/feasibility-study-for-the-non-invasive-blood-pressure-estimation-based-on-ppg-morphology-normotensive-subject-study
#3
Hangsik Shin, Se Dong Min
BACKGROUND: Blood pressure is a critical bio-signal and its importance has been increased with the aged society and the growth of cardiovascular disease population. However, most of hypertensive patients have been suffered the inconvenience in monitoring blood pressure in daily life because the measurement of the blood pressure depends on the cuff-based technique. Nowadays there are many trials to measure blood pressure without cuff, especially, photoplethysmography (PPG) based research is carried out in various ways...
January 10, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28074474/optimal-defense-theory-explains-deviations-from-latitudinal-herbivory-defense-hypothesis
#4
Nicholas J Kooyers, Benjamin K Blackman, Liza M Holeski
The latitudinal herbivory defense hypothesis (LHDH) postulates that the prevalence of species interactions, including herbivory, is greater at lower latitudes, leading to selection for increased levels of plant defense. While latitudinal defense clines may be caused by spatial variation in herbivore pressure, optimal defense theory predicts that clines could also be caused by ecogeographic variation in the cost of defense. For instance, allocation of resources to defense may not increase plant fitness when growing seasons are short and plants must reproduce quickly...
January 10, 2017: Ecology
https://www.readbyqxmd.com/read/28066708/right-inferior-frontal-cortex-activity-correlates-with-tolcapone-responsivity-in-problem-and-pathological-gamblers
#5
Andrew S Kayser, Taylor Vega, Dawn Weinstein, Jan Peters, Jennifer M Mitchell
Failures of self-regulation in problem and pathological gambling (PPG) are thought to emerge from failures of top-down control, reflected neurophysiologically in a reduced capacity of prefrontal cortex to influence activity within subcortical structures. In patients with addictions, these impairments have been argued to alter evaluation of reward within dopaminergic neuromodulatory systems. Previously we demonstrated that augmenting dopamine tone in frontal cortex via use of tolcapone, an inhibitor of the dopamine-degrading enzyme catechol-O-methyltransferase (COMT), reduced delay discounting, a measure of impulsivity, in healthy subjects...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28061368/modeling-of-the-photoplethysmogram-during-atrial-fibrillation
#6
Andrius Sološenko, Andrius Petrėnas, Vaidotas Marozas, Leif Sörnmo
A phenomenological model for simulating the photoplethysmogram (PPG) during atrial fibrillation (AF) is proposed. The simulated PPG is solely based on RR interval information, and, therefore, any annotated ECG database can be used to model sinus rhythm, AF, or rhythms with premature beats. A PPG pulse is modeled by a linear combination of a log-normal and two Gaussian waveforms. The model PPG is obtained by placing individual pulses according to the RR intervals so that a connected signal is created. The model is evaluated on synchronously recorded ECG and PPG signals from the MIMIC and the University of Queensland Vital Signs Dataset databases...
December 28, 2016: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28055986/robust-heart-rate-estimation-using-wrist-type-photoplethysmographic-signals-during-physical-exercise-an-approach-based-on-adaptive-filtering
#7
Sibylle Fallet, Jean-Marc Vesin
Photoplethysmographic (PPG) signals are easily corrupted by motion artifacts when the subjects perform physical exercise. This paper introduces a two-step processing scheme to estimate heart rate (HR) from wrist-type PPG signals strongly corrupted by motion artifacts. Adaptive noise cancellation, using normalized least-mean-square algorithm, is first performed to attenuate motion artifacts and reconstruct multiple PPG waveforms from different combinations of corrupted PPG waveforms and accelerometer data. An adaptive band-pass filter is then used to track the common instantaneous frequency component (i...
January 5, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28055981/combining-finger-and-toe-photoplethysmograms-for-the-detection-of-atherosclerosis
#8
Mikko Peltokangas, Antti Vehkaoja, Matti Huotari, Jarmo Verho, Ville M Mattila, Juha Röning, Pekka Romsi, Jukka Lekkala, Niku Oksala
: In this study, we propose and analyze a noninvasive method for detecting the atherosclerotic changes of vasculature based on the analysis of photoplethysmographic (PPG) signals. METHODS: the proposed method is called finger-toe (FT)-plot analysis that utilizes both finger and toe PPG signals. For the features extracted from the FT-plots, we implemented different linear discriminant analysis based classifiers and analyzed seven promising ones in detail. We used the signals recorded from altogether 75 test subjects (categorized as 27 atherosclerotic patients and 48 control subjects based on ankle brachial pressure index, symptoms and disease history) in the training, and testing of the method...
January 5, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28055230/improved-postprandial-glycemic-control-with-faster-acting-insulin-aspart-in-patients-with-type-1-diabetes-using-continuous-subcutaneous-insulin-infusion
#9
Bruce W Bode, Joseph A Johnson, Liselotte Hyveled, Søren C Tamer, Marek Demissie
BACKGROUND: Faster aspart is insulin aspart (IAsp) in a new formulation, which in continuous subcutaneous insulin infusion (CSII) in subjects with type 1 diabetes has shown a faster onset and offset of glucose-lowering effect than IAsp. METHODS: This double-blind, randomized, crossover active-controlled trial compared 2-h postprandial plasma glucose (PPG) response, following 2 weeks of CSII with faster aspart or IAsp. Primary endpoint: mean change in PPG 2 h after a standardized meal test (ΔPGav,0-2h)...
January 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28050765/association-of-periodontal-disease-with-glycemic-control-in-patients-with-type-2-diabetes-in-indian-population
#10
Palka Kaur Khanuja, Satish Chander Narula, Rajesh Rajput, Rajinder Kumar Sharma, Shikha Tewari
This study aims to investigate the link between glycated hemoglobin and diabetic complications with chronic periodontitis. A total of 207 patients with type 2 diabetes and chronic periodontitis (CP) were divided according to tertiles of mean PISA (periodontal inflamed surface area) scores as low, middle and high PISA groups. Simultaneously a group of 67 periodontally healthy individuals (PH) was recruited. Periodontal examinations, including full-mouth assessment of probing depths (PPD), bleeding on probing, clinical attachment level and plaque scores were determined...
January 3, 2017: Frontiers of Medicine
https://www.readbyqxmd.com/read/28045611/establishment-of-personalized-pain-goals-in-oncology-patients-to-improve-care-and-decrease-costs
#11
Dylan Zylla, Amber Larson, Gladys Chuy, Lisa Illig, Adina Peck, Sarah Van Peursem, James W Fulbright, Pamala A Pawloski, Sara Richter, Jeanne Mettner
PURPOSE: Cancer-related pain is common, negatively affects quality of life and survival, and often requires treatment with opioid analgesics. Patient-reported data that describe the incidence and severity of pain, medication use, and patient satisfaction with care are lacking. METHODS: We analyzed 18 months of outpatient oncology clinic encounters from the electronic medical record to obtain data on pain levels and opioid and nonopioid treatments. In June 2014, we instituted a pain intervention by creating a pain management information handout for patients, educating clinicians on opioid cost-effectiveness, and implementing a nursing protocol to document personalized pain goals (PPGs)...
January 3, 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/28033109/photoplethysmography-for-an-independent-measure-of-pulsatile-pressure-under-controlled-flow-conditions
#12
Haneen Njoum, Panayiotis A Kyriacou
Noninvasive continuous blood pressure measurements are desirable for patients and clinicians. This work proposes and validates a method for transmural pressure measurement using photoplethysmography (PPG) in an in vitro setup that allows control of pressure and flow conditions. The optimum pulsatile volume measure is obtained by comparing parameters extracted from the photoplethysmographic signal (AC amplitude, normalized pulse volume (NPV) and adjusted pulse volume (APV)). Pulsatile volume can then provide pressure measurements using the exponential pressure-volume (P-V) relationship and validated using the gold standard catheter pressure measurement...
December 29, 2016: Physiological Measurement
https://www.readbyqxmd.com/read/28032550/three-year-results-of-a-randomized-study-comparing-self-gripping-mesh-with-sutured-mesh-in-open-inguinal-hernia-repair
#13
Ceith Nikkolo, Tiit Vaasna, Marko Murruste, Jaanus Suumann, Ülle Kirsimägi, Helmut Seepter, Andres Tein, Urmas Lepner
BACKGROUND: The primary aim of the present study was to evaluate whether usage of self-gripping mesh in open inguinal hernia repair, compared with standard Lichtenstein repair with sutured mesh, could result in a decreased rate of chronic pain. The secondary aim was to evaluate the rate of foreign body feeling, hernia recurrence, and risk factors for chronic pain development. METHODS: The patients were randomized into two study groups: the OLP group received Optilene LP mesh and the PPG group received self-gripping Parietex ProGrip mesh...
October 15, 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/28012294/derivation-of-respiration-rate-from-ambulatory-ecg-and-ppg-using-ensemble-empirical-mode-decomposition-comparison-and-fusion
#14
Christina Orphanidou
A new method for extracting the respiratory rate from ECG and PPG obtained via wearable sensors is presented. The proposed technique employs Ensemble Empirical Mode Decomposition in order to identify the respiration "mode" from the noise-corrupted Heart Rate Variability/Pulse Rate Variability and Amplitude Modulation signals extracted from ECG and PPG signals. The technique was validated with respect to a Respiratory Impedance Pneumography (RIP) signal using the mean absolute and the average relative errors for a group ambulatory hospital patients...
December 7, 2016: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/27995405/comparison-of-colonoscopy-quality-measures-across-various-practice-settings-and-the-impact-of-performance-scorecards
#15
Jennifer A Inra, Jennifer Nayor, Margery Rosenblatt, Muthoka Mutinga, Sarathchandra I Reddy, Sapna Syngal, Fay Kastrinos
BACKGROUND: Quality performance measures for screening colonoscopy vary among endoscopists. The impact of practice setting is unknown. AIMS: We aimed to (1) compare screening colonoscopy performance measures among three different US practice settings; (2) evaluate factors associated with adenoma detection; and (3) assess a scorecard intervention on performance metrics. METHODS: This multi-center prospective study compared patient, endoscopist, and colonoscopy characteristics performed at a tertiary care hospital (TCH), community-based hospital (CBH), and private practice group (PPG)...
December 19, 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/27992351/bio-witel-a-low-power-integrated-wireless-telemetry-system-for-healthcare-applications-in-401-406-mhz-band-of-medradio-spectrum
#16
Abhishek Srivastava, Nithin Sankar, Baibhab Chatterjee, Devarshi Das, Meraj Ahmad, Rakesh Kukkundoor, Vivek Saraf, Ananthpadmanabhan Jayachandran, Dinesh Sharma, Maryam Baghini
This paper presents a low power integrated wireless telemetry system (Bio-WiTel) for healthcare applications in 401- 406 MHz frequency band of Medical Device RadioCommunication (MedRadio) spectrum. In this work, necessary design considerations for telemetry system for short range (upto 3 m) communication of bio-signals are presented. These considerations greatly help in taking important design decisions, which eventually lead to a simple, low power, robust and reliable wireless system implementation. Transmitter (TX) and receiver (RX) of Bio-WiTel system have been fabricated in 180 nm mixed mode CMOS technology...
December 14, 2016: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/27986406/addition-of-once-daily-prandial-lixisenatide-to-basal-insulin-therapy-in-patients-with-type-2-diabetes-results-in-a-reduction-of-hba1c-as-an-effect-of-postprandial-glucose-lowering
#17
Holger Fleischmann, Rüdiger Göke, Peter Bramlage
AIMS: Basal insulin has been shown to effectively reduce fasting blood glucose (FBG), but postprandial plasma glucose (PPG) excursions may remain higher than normal. Glucagon-like peptide (GLP)-1 receptor agonists such as the short-acting lixisenatide are able to control such excursions by slowing gastric emptying. However, data regarding its use in a real world clinical setting are scarce. METHODS: 24 week, prospective, multicentre, non-interventional study in 1437 patients with type-2 diabetes receiving 20μg lixisenatide once daily in combination with basal insulin...
December 12, 2016: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/27976741/weighing-scale-based-pulse-transit-time-is-a-superior-marker-of-blood-pressure-than-conventional-pulse-arrival-time
#18
Stephanie L-O Martin, Andrew M Carek, Chang-Sei Kim, Hazar Ashouri, Omer T Inan, Jin-Oh Hahn, Ramakrishna Mukkamala
Pulse transit time (PTT) is being widely pursued for cuff-less blood pressure (BP) monitoring. Most efforts have employed the time delay between ECG and finger photoplethysmography (PPG) waveforms as a convenient surrogate of PTT. However, these conventional pulse arrival time (PAT) measurements include the pre-ejection period (PEP) and the time delay through small, muscular arteries and may thus be an unreliable marker of BP. We assessed a bathroom weighing scale-like system for convenient measurement of ballistocardiography and foot PPG waveforms - and thus PTT through larger, more elastic arteries - in terms of its ability to improve tracking of BP in individual subjects...
December 15, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27975066/association-of-postbreakfast-triglyceride-and-visit-to-visit-annual-variation-of-fasting-plasma-glucose-with-progression-of-diabetic-nephropathy-in-patients-with-type-2-diabetes
#19
Kaori Kitaoka, Akiko Takenouchi, Ayaka Tsuboi, Keisuke Fukuo, Tsutomu Kazumi
Urinary albumin/creatinine ratio (ACR) was measured at baseline and after a median follow-up of 6.0 years in 161 patients with type 2 diabetes. Intrapersonal means and SD of HbA1c, systolic BP, fasting, and postmeal plasma glucose (FPG and PMPG, resp.) and serum triglycerides (FTG and PMTG, resp.) were calculated in each patient during the first 12 months after enrollment. Associations of these variables with nephropathy progression (15 patients with progression of albuminuric stages and 5 with ACR doubling within the microalbuminuric range) were determined by multivariate logistic regression analysis providing odds ratio with 95% confidential interval...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27973556/application-of-mixed-effects-limits-of-agreement-in-the-presence-of-multiple-sources-of-variability-exemplar-from-the-comparison-of-several-devices-to-measure-respiratory-rate-in-copd-patients
#20
Richard A Parker, Christopher J Weir, Noah Rubio, Roberto Rabinovich, Hilary Pinnock, Janet Hanley, Lucy McCloughan, Ellen M Drost, Leandro C Mantoani, William MacNee, Brian McKinstry
INTRODUCTION: The Bland-Altman limits of agreement method is widely used to assess how well the measurements produced by two raters, devices or systems agree with each other. However, mixed effects versions of the method which take into account multiple sources of variability are less well described in the literature. We address the practical challenges of applying mixed effects limits of agreement to the comparison of several devices to measure respiratory rate in patients with chronic obstructive pulmonary disease (COPD)...
2016: PloS One
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