Andrew I Efimov, Timothy J Hibberd, Yue Wang, Mingzheng Wu, Kaiqing Zhang, Kaila Ting, Surabhi Madhvapathy, Min-Kyu Lee, Joohee Kim, Jiheon Kang, Mohammad Riahi, Haohui Zhang, Lee Travis, Emily J Govier, Lianye Yang, Nigel Kelly, Yonggang Huang, Abraham Vázquez-Guardado, Nick J Spencer, John A Rogers
Wireless activation of the enteric nervous system (ENS) in freely moving animals with implantable optogenetic devices offers a unique and exciting opportunity to selectively control gastrointestinal (GI) transit in vivo, including the gut-brain axis. Programmed delivery of light to targeted locations in the GI-tract, however, poses many challenges not encountered within the central nervous system (CNS). We report here the development of a fully implantable, battery-free wireless device specifically designed for optogenetic control of the GI-tract, capable of generating sufficient light over large areas to robustly activate the ENS, potently inducing colonic motility ex vivo and increased propulsion in vivo...
April 16, 2024: Biosensors & Bioelectronics