Daniel Keene, Alejandra A Miyazawa, Ahran D Arnold, Akriti Naraen, Nandita Kaza, Jagdeep S Mohal, David C Lefroy, Phang Boon Lim, Fu Siong Ng, Michael Koa-Wing, Norman A Qureshi, Nick W F Linton, Ian Wright, Nicholas S Peters, Prapa Kanagaratnam, Matthew J Shun-Shin, Darrel P Francis, Zachary I Whinnett
BACKGROUND: Ventricular tachycardia (VT) reduces cardiac output through high heart rates, loss of atrioventricular synchrony, and loss of ventricular synchrony. We studied the contribution of each mechanism and explored the potential therapeutic utility of His bundle pacing to improve cardiac output during VT. METHODS: Study 1 aimed to improve the understanding of mechanisms of harm during VT (using pacing simulated VT). In 23 patients with left ventricular impairment, we recorded continuous ECG and beat-by-beat blood pressure measurements...
April 22, 2024: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing