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https://www.readbyqxmd.com/read/29793197/association-of-low-moderate-urine-arsenic-and-qt-interval-cross-sectional-and-longitudinal-evidence-from-the-strong-heart-study
#1
Katherine A Moon, Yiyi Zhang, Eliseo Guallar, Kevin A Francesconi, Walter Goessler, Jason G Umans, Lyle G Best, Barbara V Howard, Richard B Devereux, Peter M Okin, Ana Navas-Acien
Epidemiologic studies suggest that chronic exposure to arsenic is related to cardiovascular disease (CVD), but the pathophysiological link remains uncertain. We evaluated the association of chronic low-moderate arsenic exposure and arsenic metabolism with baseline difference and annual change in ECG measures (QT interval, JT interval, PR interval, QRS duration, and QT dispersion) using linear mixed models in the Strong Heart Study main cohort (N = 1174, median age 55 years) and family study (N = 1695 diabetes-free, median age 36 years)...
May 21, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29793053/aggressive-fluid-and-sodium-restriction-in-decompensated-heart-failure-with-preserved-ejection-fraction-results-from-a-randomized-clinical-trial
#2
Karina Sanches Machado d'Almeida, Eneida Rejane Rabelo-Silva, Gabriela Corrêa Souza, Melina Maria Trojahn, Sofia Louise Santin Barilli, Graziella Aliti, Luís Eduardo Rohde, Andreia Biolo, Luís Beck-da-Silva
OBJECTIVES: Sodium and fluid restriction is commonly prescribed for heart failure patients. However, its role in the treatment of heart failure with preserved ejection fraction (HFpEF) remains unclear. The aim of this study was to compare the effect of a diet with sodium and fluid restriction with an unrestricted diet in patients admitted for decompensated HFpEF. METHODS: Patients were randomized to a diet with sodium (0.8 g/d) and fluid (800 mL/d) restriction (intervention group [IG]) or an unrestricted diet (control group [CG]) and followed for 7 d or hospital discharge...
March 21, 2018: Nutrition
https://www.readbyqxmd.com/read/29792509/modulation-of-excitability-in-the-temporoparietal-junction-relieves-virtual-reality-sickness
#3
Naoyuki Takeuchi, Takayuki Mori, Yoshimi Suzukamo, Shin-Ichi Izumi
Virtual reality (VR) immersion often provokes subjective discomfort and postural instability, so called VR sickness. The neural mechanism of VR sickness is speculated to be related to visual-vestibular information mismatch and/or postural instability. However, the approaches proposed to relieve VR sickness through modulation of brain activity are poorly understood. Using transcranial direct current stimulation (tDCS), we aimed to investigate whether VR sickness could be relieved by the modulation of cortical excitability in the temporoparietal junction (TPJ), which is known to be involved in processing of both vestibular and visual information...
May 24, 2018: Cyberpsychology, Behavior and Social Networking
https://www.readbyqxmd.com/read/29792062/analysis-of-the-blood-viscosity-behavior-in-the-sicilian-study-on-juvenile-myocardial-infarction
#4
Gregorio Caimi, Eugenia Hopps, Maria Montana, Giuseppe Andolina, Caterina Urso, Baldassare Canino, Rosalia Lo Presti
Considering the role of hemorheology in coronary circulation, we studied blood viscosity in patients with juvenile myocardial infarction. We examined whole blood viscosity at high shear rate using the cone-on-plate viscosimeter Wells-Brookfield ½ LVT and at low shear rate employing a viscometer Contraves LS30 in 120 patients (aged <46 years) with myocardial infarction, at the initial stage and subsequently 3 and 12 months after. At the initial stage, patients had an increased whole blood viscosity in comparison to normal controls...
January 1, 2018: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/29791869/ghrelin-and-the-heart
#5
Takeshi Tokudome, Kentaro Otani, Mikiya Miyazato, Kenji Kangawa
Ghrelin, a growth hormone-releasing peptide that was first discovered in the stomach of rats in 1999, is an endogenous ligand of growth hormone secretagogue receptor. Ghrelin exerts its potent growth hormone-releasing and orexigenic activities by binding to specific receptors in the brain. Subsequent studies showed that ghrelin participates in the regulation of diverse processes, including energy balance, body weight maintenance, and glucose and fat metabolism, and demonstrated that ghrelin is beneficial for treatment of cardiac diseases...
May 20, 2018: Peptides
https://www.readbyqxmd.com/read/29791649/bouts-of-exercise-elicit-discordant-testosterone-cortisol-ratios-in-runners-and-non-runners
#6
Thiago Paes de Barros De Luccia, José Eduardo Soubhia Natali, Alexandre Moreira, José Guilherme Chaui-Berlinck, José Eduardo Pereira Wilken Bicudo
OBJECTIVE: The testosterone:cortisol ratio (T:C) is suggested to be used in order to examine whether physical exercise generates either a "catabolic environment" or an "anabolic environment". The present study aims to evaluate the acute time-course profile of cortisol and testosterone due to an episode of physical exercise. A biphasic profile in the T:C ratio response was hypothesized. MATERIALS AND METHODS: Morning sessions of treadmill running at two different intensities (Heart Rate at 65% and 80% of the maximum cardiac reserve) were performed by 6 male non-runners (NR) and 12 trained male runners (subdivided into trained runners T1 and T2)...
May 17, 2018: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29791601/resting-spontaneous-baroreflex-sensitivity-and-cardiac-autonomic-control-in-anabolic-androgenic-steroid-users
#7
Marcelo R Dos Santos, Ana L C Sayegh, Rafael Armani, Valéria Costa-Hong, Francis R de Souza, Edgar Toschi-Dias, Luiz A Bortolotto, Mauricio Yonamine, Carlos E Negrão, Maria-Janieire N N Alves
OBJECTIVES: Misuse of anabolic androgenic steroids in athletes is a strategy used to enhance strength and skeletal muscle hypertrophy. However, its abuse leads to an imbalance in muscle sympathetic nerve activity, increased vascular resistance, and increased blood pressure. However, the mechanisms underlying these alterations are still unknown. Therefore, we tested whether anabolic androgenic steroids could impair resting baroreflex sensitivity and cardiac sympathovagal control. In addition, we evaluate pulse wave velocity to ascertain the arterial stiffness of large vessels...
May 21, 2018: Clinics
https://www.readbyqxmd.com/read/29791599/ultra-short-term-heart-rate-variability-during-resistance-exercise-in-the-elderly
#8
G P T Arêas, F C R Caruso, R P Simões, V Castello-Simões, R B Jaenisch, T O Sato, R Cabiddu, R Mendes, R Arena, A Borghi-Silva
Despite the appeal of ultra-short-term heart rate variability (HRV) methods of analysis applied in the clinical and research settings, the number of studies that have investigated HRV by analyzing R-R interval (RRi) recordings shorter than 5 min is still limited. Moreover, ultra-short-term HRV analysis has not been extensively validated during exercise and, currently, no indications exist for its applicability during resistance exercise. The aim of the present study was to compare ultra-short-term HRV analysis with standard short-term HRV analysis during low-intensity, dynamic, lower limb resistance exercise in healthy elderly subjects...
2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29791321/innovative-multi-site-photoplethysmography-measurement-and-analysis-demonstrating-increased-arterial-stiffness-in-paediatric-heart-transplant-recipients
#9
Emma J Sharkey, Costanzo Di Maria, Annette Klinge, Alan Murray, Dingchang Zheng, John O'Sullivan, John Allen
OBJECTIVE: It has been documented that heart transplantation in children is often complicated by arterial hypertension and increased arterial stiffness. AIM: to use innovative multi-site photoplethysmography (MPPG) pulse measurement and analysis technology to assess arterial stiffness change in paediatric heart transplant recipients (HTR) in comparison with healthy control (HC) children. &#13; &#13; Approach: 20 heart transplant (median age 13.5 years old) (8 male) recipients were compared to an overall age- and gender-matched group of 161 healthy controls (11...
May 23, 2018: Physiological Measurement
https://www.readbyqxmd.com/read/29791320/modelling-the-cerebral-haemodynamic-response-in-the-physiological-range-of-paco-sub-2-sub
#10
Jatinder Singh Minhas, Ronney B Panerai, Thompson G Robinson
Objective&#13; Arterial CO&lt;sub&gt;2&lt;/sub&gt; (PaCO&lt;sub&gt;2&lt;/sub&gt;) has a strong effect on cerebral blood flow (CBF), but its influence on CBF regulatory mechanisms and circulatory systemic variables has not been fully described over the entire physiological range of PaCO&lt;sub&gt;2&lt;/sub&gt;. &#13; &#13; Approach&#13; CBF velocity (CBV, transcranial Doppler), blood pressure (BP, Finometer) and end-tidal CO&lt;sub&gt;2&lt;/sub&gt; (EtCO&lt;sub&gt;2&lt;/sub&gt;, capnography) were measured in 45 healthy volunteers (19 male, mean age 37...
May 23, 2018: Physiological Measurement
https://www.readbyqxmd.com/read/29791284/risk-imaging-mismatch-in-cardiac-imaging-practices-for-women-receiving-systemic-therapy-for-early-stage-breast-cancer-a-population-based-cohort-study
#11
Paaladinesh Thavendiranathan, Husam Abdel-Qadir, Hadas D Fischer, Ying Liu, Ximena Camacho, Eitan Amir, Peter C Austin, Douglas S Lee
Purpose To assess prechemotherapy cardiac imaging practices in relation to patients' heart failure (HF) risk. Methods We performed a population-based retrospective cohort study of women receiving chemotherapy for early-stage breast cancer in Ontario between 2007 and 2012. We surveyed for baseline cardiac imaging 6 months before chemotherapy or within 30 days thereafter. The proportion of patients who underwent imaging and cumulative incidence of major adverse cardiac event (MACE) rates was determined based on chemotherapy regimen and HF risk factors...
May 23, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29791084/the-hospital-readmissions-reduction-program-learning-from-failure-of-a-healthcare-policy
#12
REVIEW
Ankur Gupta, Gregg C Fonarow
Heart failure is the leading cause of readmissions in patients aged ≥65 years with high associated societal and economic costs. The utilization metric of 30-day risk standardized readmission rates (RSRRs) has therefore become a target to reduce healthcare costs. In this review, we discuss in detail the implementation, effectiveness, and unintended consequences of the Hospital Readmissions Reduction Program (HRRP)-the major healthcare policy approach in the U.S. to reduce readmissions by financially penalizing hospitals with higher than average 30-day RSRRs...
May 23, 2018: European Journal of Heart Failure
https://www.readbyqxmd.com/read/29791058/gene-flow-does-not-prevent-personality-and-morphological-differentiation-between-two-blue-tit-populations
#13
Gabrielle Dubuc-Messier, Samuel P Caro, Charles Perrier, Kees van Oers, Denis Réale, Anne Charmantier
Understanding the causes and consequences of population phenotypic divergence is a central goal in ecology and evolution. Phenotypic divergence among populations can result from genetic divergence, phenotypic plasticity or a combination of the two. However, few studies have deciphered these mechanisms for populations geographically close and connected by gene flow, especially in the case of personality traits. In this study, we used a common garden experiment to explore the genetic basis of the phenotypic divergence observed between two blue tit (Cyanistes caeruleus) populations inhabiting contrasting habitats separated by 25 km, for two personality traits (exploration speed and handling aggression), one physiological trait (heart rate during restraint) and two morphological traits (tarsus length and body mass)...
May 23, 2018: Journal of Evolutionary Biology
https://www.readbyqxmd.com/read/29790794/association-of-morning-blood-pressure-surge-with-carotid-intima-media-thickness-and-cardiac-dysfunction-in-patients-with-cardiac-syndrome-x
#14
Ragab A Mahfouz, Mohammad Goda, Islam Galal, Mohamed S Ghareb
Background & hypothesis: We hypothesized that exaggerated morning blood pressure surge, may contribute in cardiac dysfunction and arterial stiffness in patients with cardiac syndrome X. Thus we investigated the impact of morning blood pressure surge on cardiac function and carotid intima-media thickness in subjects with cardiac syndrome X. METHODS: We studied patients with cardiac syndrome X using ambulatory blood pressure monitoring and investigated the association of morning blood pressure surge with carotid intima thickness, left atrial volume index and left ventricular filling (E/e')...
May 23, 2018: Blood Pressure
https://www.readbyqxmd.com/read/29790603/hyperkalaemia-in-people-with-diabetes-occurrence-risk-factors-and-outcomes-in-a-danish-population-based-cohort-study
#15
R W Thomsen, S K Nicolaisen, K Adelborg, E Svensson, P Hasvold, E Palaka, L Pedersen, H T Sørensen
AIMS: To examine the incidence, risk factors and clinical outcomes of hyperkalaemia in people with diabetes in a real-world setting. METHODS: Using Danish health registries, we identified a population-based cohort of people with first-time drug-treated diabetes, in the period 2000-2012. First, the cumulative incidence of hyperkalaemia, defined as first blood test with potassium level >5.0 mmol/l after diabetes treatment initiation, was ascertained. Second, in a case-control analysis, risk factors were compared in people with vs without hyperkalaemia...
May 23, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29790209/subclinical-leaflet-thrombosis-following-transcatheter-aortic-valve-replacement
#16
Somsupha Kanjanauthai, Luigi Pirelli, Nikhil Nalluri, Chad A Kliger
Since the inception of transcatheter aortic valve replacement (TAVR), there have been significant reductions in complications due to improvements of transcatheter heart valve (THV) designs and technologies. Given expanding TAVR applications, reducing complications further and better understanding THV durability has become a focus within the structural heart space. Recently, dedicated cardiac computed tomographic angiography (CTA) performed at 1 month post-TAVR has identified subclinical leaflet thrombosis (SLT), with rates as high as 40%...
May 23, 2018: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/29790182/effect-of-chronic-toluene-exposure-on-heart-rhythm-parameters
#17
Sukru Arslan, Isil Uzunhasan, Betul Balaban Kocas, Gokhan Cetinkal, Seyma Arslan, Cuneyt Kocas, Okay Abaci, Mustafa Yildiz, Cengiz Celiker, Cengizhan Turkoglu
BACKGROUND: Toluene is used extensively in various industrial processes, and an increasing number of workers are getting exposed to its vapor. Cardiac abnormalities that have been reported in association with toluene exposure (in toxic doses) are atrioventricular conduction abnormalities, sinus bradycardia, ventricular tachycardia, recurrent myocardial infarction, dilated cardiomyopathy, and coronary vasospasm. HYPOTHESIS: We aimed to investigate the effects of chronic toluene exposure on cardiac rhythm...
May 22, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29790159/development-of-a-new-analgesic-index-using-nasal-photoplethysmography
#18
B M Choi, C Park, Y H Lee, H Shin, S H Lee, S Jeong, G J Noh, B Lee
Although surrogate measures to quantify pain intensity have been commercialised, there is a need to develop a new index with improved accuracy. The aim of this study was to develop a new analgesic index using nasal photoplethysmography data. The specially designed sensor was placed between the columella and the nasal septum to acquire nasal photoplethysmography in surgical patients. Nasal photoplethysmography and Surgical Pleth Index® (GE Healthcare) data were obtained for 14 min both in the absence (pre-operatively) or presence (postoperatively) of pain in a group of surgical patients, each patient acting as their own control...
May 23, 2018: Anaesthesia
https://www.readbyqxmd.com/read/29790114/ivabradine-improved-left-ventricular-function-and-pressure-overload-induced-cardiomyocyte-apoptosis-in-a-transverse-aortic-constriction-mouse-model
#19
Yihui Yu, Zuoying Hu, Bing Li, Zhimei Wang, Shaoliang Chen
This study aimed to investigate the effects and molecular mechanisms of ivabradine in preventing cardiac hypertrophy in an established transverse aortic constriction (TAC) mouse model. A total of 56 male C57BL/6 mice were randomly assigned into the following seven groups (8 mice per group): sham, TAC model, Iva-10 (10 mg/kg/day ivabradine), Iva-20 (20 mg/kg/day ivabradine), Iva-40 (40 mg/kg/day ivabradine), Iva-80 (80 mg/kg/day ivabradine), and Rap (rapamycin, a positive control). Echocardiography and left ventricular hemodynamics were performed...
May 22, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29790109/value-of-three-dimensional-speckle-tracking-echocardiography-to-assess-left-ventricular-function-in-hyperuricemia-patients
#20
Xiaojie Zhang, Qing Lu, Zhuojun Zhang, Yongle Chen, Yanan Wang, Youngshi Wang, Zheng Li, Lindi Jiang
To assess the value of three-dimensional speckle tracking echocardiography (3D STE) in evaluating the left ventricular (LV) function in hyperuricemia patients. We enrolled 15 healthy controls and 40 hyperuricemia patients and collected and analyzed full-volume 3D STE images of the left ventricle in the apical four-chamber heart view. Laboratory tests and 3D STE parameters, including left ventricular ejection fraction, left ventricular end-diastolic volume, left ventricular end-systolic volume, stroke volume (SV), global longitudinal strain (GLS), and global circumferential strain (GCS), were compared between hyperuricemia patients and healthy controls...
May 22, 2018: Clinical Rheumatology
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