keyword
MENU ▼
Read by QxMD icon Read
search

Procalcitonin

keyword
https://www.readbyqxmd.com/read/29333810/the-value-of-acute-phase-reactants-and-lightcycler%C3%A2-septifast-test-in-the-diagnosis-of-bacterial-and-viral-infections-in-pediatric-patients
#1
Gulcin Bozlu, Huseyin Tanriverdi, Gonul Aslan, Necdet Kuyucu
INTRODUCTION: This study was performed to investigate the value of acute phase reactants and LightCycler® SeptiFast test to differentiate bacterial and viral infections. POPULATION AND METHODS: Children with fever were enrolled to this prospective study. Peripheral white blood cell (WBC), C-reactive protein (CRP) and procalcitonin (PCT) were studied from all patients on day 1, 3 and 7. Blood culture and chest X-ray were also obtained on day 1. Blood samples for LightCycler® SeptiFast test were obtained in all patients to use them if there was uncertain diagnosis between bacterial or viral infection...
February 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29332972/clinical-utility-and-measurement-of-procalcitonin
#2
REVIEW
Intan Samsudin, Samuel D Vasikaran
Procalcitonin (PCT), regarded as a biomarker specific for bacterial infections, is used in a variety of clinical settings including primary care, emergency department and intensive care. PCT measurement aids in the diagnosis of sepsis and to guide and monitor antibiotic therapy. This article gives a brief overview of PCT and its use in guiding antibiotic therapy in various clinical settings, as well as its limitations. PCT performance in comparison with other biomarkers of infection in particular CRP is also reviewed...
April 2017: Clinical Biochemist. Reviews
https://www.readbyqxmd.com/read/29332624/-not-all-exacerbations-of-chronic-obstructive-pulmonary-disease-should-be-treated-with-antibiotics
#3
Stefan Kern Nielsen, Peter Lange
This review gives an update on antibiotic treatment of exacerbation of chronic obstructive pulmonary disease (COPD). Patients who do not need hospital admission and do not present with purulent sputum nor increased levels of C reactive protein/procalcitonin have no beneficial effect of antibiotic treatment. Those with severe COPD and increased sputum purulence should be treated with antibiotics, and first-line treatment should be amoxicillin, which is effective against the most common types of bacteria in COPD exacerbation...
April 10, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29331425/low-picomolar-label-free-procalcitonin-analytical-detection-with-an-electrolyte-gated-organic-field-effect-transistor-based-electronic-immunosensor
#4
Preethi Seshadri, Kyriaki Manoli, Nicole Schneiderhan-Marra, Uwe Anthes, Piotr Wierzchowiec, Klaus Bonrad, Cinzia Di Franco, Luisa Torsi
Herein a label-free immunosensor based on electrolyte-gated organic field-effect transistor (EGOFET) was developed for the detection of procalcitonin (PCT), a sepsis marker. Antibodies specific to PCT were immobilized on the poly-3-hexylthiophene (P3HT) organic semiconductor surface through direct physical adsorption followed by a post-treatment with bovine serum albumin (BSA) which served as the blocking agent to prevent non-specific adsorption. Antibodies together with BSA (forming the whole biorecognition layer) served to selectively capture the procalcitonin target analyte...
December 26, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29327977/status-and-challenges-of-predicting-and-diagnosing-sepsis-in-burn-patients
#5
Mile Stanojcic, Roohi Vinaik, Marc G Jeschke
Burns are a common form of trauma that account for more than 300,000 deaths each year worldwide. Survival rates have improved over the past decades because of improvements in nutritional and fluid support, burn wound care, and infection control practices. Death, however, remains unacceptably high. The primary cause of death has changed over the last decades from anoxic causes to now predominantly infections and sepsis. Sepsis and septic complications are not only major contributors to poor outcomes, but they further result in longer hospital stay and higher healthcare costs...
January 12, 2018: Surgical Infections
https://www.readbyqxmd.com/read/29322872/a-collaborative-approach-to-improve-consistent-use-of-procalcitonin-in-lower-respiratory-tract-infections
#6
Alexander R Levine, Robyn Riggott, Kristela Vulaj, Tera R Falcetti, Syed Ali, Gagandeep Singh
BACKGROUND: Procalcitonin (PCT) is a biomarker that can help differentiate bacterial from viral infections and has been extensively studied in patients with sepsis and pneumonia to guide antibiotic therapy. However, there is poor adherence to prescribed algorithms when used to discontinue antibiotics in the real world. A quality improvement project was implemented to increase consistent use of PCT. OBJECTIVE: To evaluate use of PCT and impact on antibiotic length of therapy (LOT) preimplementation and postimplementation of a quality improvement initiative...
January 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29322854/are-platelet-volume-indices-related-to-mortality-in-hospitalized-children-on-mechanical-ventilation
#7
Sheng Ye, Yanyi Zhang, Chenmei Zhang, Dan Xu
Objectives To investigate platelet volume indices and in-hospital mortality in children on mechanical ventilation. Methods This retrospective study included children aged <16 years on mechanical ventilation, and compared parameters, measured on admission, between survivors and non-survivors. Dynamic platelet volume indices over the first 7 days were visualized. Independent risk factors of mortality were identified using multivariate logistic regression analysis. Results Out of 2 319 children aged 28 days-3 years, serum albumin (odds ratio [OR] 0...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29320362/predictive-value-of-serum-gelsolin-and-gc-globulin-in-sepsis-a-pilot-study
#8
Zoltán Horváth-Szalai, Péter Kustán, Balázs Szirmay, Ágnes Lakatos, Per Hjort Christensen, Tamás Huber, Beáta Bugyi, Diána Mühl, Andrea Ludány, Attila Miseta, Gábor L Kovács, Tamás Kőszegi
BACKGROUND: Simultaneous determination of the two main actin scavenger proteins in sepsis has not been investigated until now. In our pilot study, we elucidated the predictive values of Gc globulin and gelsolin (GSN) in sepsis by comparing them to classic laboratory and clinical parameters. METHODS: A 5-day follow-up was performed, including 46 septic patients, 28 non-septic patients and 35 outpatients as controls. Serum Gc globulin and GSN levels were determined by automated immune turbidimetric assay on a Cobas 8000/c502 analyzer...
January 10, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29315994/prediction-of-histological-chorioamnionitis-and-neonatal-and-infantile-outcomes-using-procalcitonin-in-the-umbilical-cord-blood-and-amniotic-fluid-at-birth
#9
Takashi Horinouchi, Toshiyuki Yoshizato, Yutaka Kozuma, Takaaki Shinagawa, Megumi Muto, Tsuyoshi Yamasaki, Daizo Hori, Kimio Ushijima
AIM: We aimed to clarify the usefulness of procalcitonin (PCT) in the evaluation of histological chorioamnionitis (CAM) and in the prediction of neonatal and infantile outcomes as a reference of interleukin-6 (IL-6). METHODS: Subjects were 36 singleton pregnant women delivered at 22-37 weeks' gestation due to threatened premature delivery and/or preterm premature rupture of membranes. Cases were classified into the CAM and non-CAM groups, according to Blanc's criteria...
January 5, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29314200/effects-of-s100a12-gene-silencing-on-serum-levels-of-anti-inflammatory-pro-inflammatory-cytokines-in-septic-rats-through-the-erk-signaling-pathway
#10
Xin Wen, Xin-Rui Han, Yong-Jian Wang, Shao-Hua Fan, Zi-Feng Zhang, Dong-Mei Wu, Jun Lu, Yuan-Lin Zheng
We explored the effect of S100A12 gene on serum levels of anti-inflammatory/pro-inflammatory cytokines in septic rats by activating the extracellular signal-regulated kinase (ERK) signaling pathway. A total of 180 specific pathogen-free (SPF) rats were purchased to establish cecal ligation and puncture (CLP) model. Rats were assigned into the sham, model, empty vector, S100A12 siRNA, epidermal growth factor (EGF) and S100A12 siRNA + EGF groups. The expressions of S100A12, ERK-1, ERK-2, cPLA2 and NF-κB in liver tissues of rats among six groups were detected by RT-qPCR and western blotting...
January 3, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29312687/procalcitonin-use-for-shorter-courses-of-antibiotic-therapy-in-suspected-early-onset-neonatal-sepsis-are-we-getting-there
#11
EDITORIAL
Despoina Gkentzi, Gabriel Dimitriou
No abstract text is available yet for this article.
December 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29308071/positive-correlation-of-airway-resistance-and-serum-asymmetric-dimethylarginine-adma-in-bronchial-asthma-patients-lacking-evidence-for-systemic-inflammation
#12
Gabor Tajti, Csaba Papp, Laszlo Kardos, Sandor Keki, Krisztian Pak, Magdolna Emma Szilasi, Rudolf Gesztelyi, Angela Mikaczo, Andrea Fodor, Maria Szilasi, Judit Zsuga
Background: Contribution of nitric-oxide (NO) pathway to the pathogenesis of bronchial asthma (asthma) is ambiguous as NO may confer both protective and detrimental effects depending on the NO synthase (NOS) isoforms, tissue compartments and underlying pathological conditions (e.g. systemic inflammation). Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor and uncoupler of NOS with distinct selectivity for NOS isoforms. In a cross-sectional study, we assessed whether ADMA is an independent predictor of airway resistance (Raw) in therapy-controlled asthma...
2018: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/29307988/procalcitonin-in-inflammatory-bowel-disease-drawbacks-and-opportunities
#13
REVIEW
Giuseppe Lippi, Fabian Sanchis-Gomar
The measurement of procalcitonin has recently become a mainstay for the diagnosis and therapeutic management of severe bacterial infections, especially those sustained by Gram-negative bacteria. Therefore, the aim of this article is to provide a narrative overview on the potential role of procalcitonin measurement in patients with inflammatory bowel disease (IBD). According to the available scientific literature, the clinical significance of procalcitonin for diagnosing IBD or monitoring disease activity remains elusive, and its association with disease severity is confined to a limited number of case-control studies, with low sample size...
December 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29305753/systematic-review-and-meta-analysis-of-the-use-of-serum-procalcitonin-levels-to-predict-intra-abdominal-infections-after-colorectal-surgery
#14
Winson Jianhong Tan, Wan Qi Ng, Rehena Sultana, Nurun Nisa de Souza, Min Hoe Chew, Fung Joon Foo, Choong Leong Tang, Wah Siew Tan
PURPOSE: There has been much recent interest in the use of procalcitonin (PCT) as a marker of intra-abdominal infection (IAI) following colorectal surgery. However, the literature remains divided on the value of PCT in this setting. This meta-analysis aims to evaluate the value of PCT in predicting IAI after colorectal surgery. METHODS: Systemic literature search was performed using MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials (CENTRAL) and the Cochrane Database of Systematic Reviews to identify studies evaluating the diagnostic accuracy of PCT as a predictor for detecting IAI on postoperative days (POD) 3 to 5 following colorectal surgery...
January 5, 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29303798/decrease-in-histidine-rich-glycoprotein-as-a-novel-biomarker-to-predict-sepsis-among-systemic-inflammatory-response-syndrome
#15
Kosuke Kuroda, Hidenori Wake, Shuji Mori, Shiro Hinotsu, Masahiro Nishibori, Hiroshi Morimatsu
OBJECTIVES: Many biomarkers for sepsis are used in clinical practice; however, few have become the standard. We measured plasma histidine-rich glycoprotein levels in patients with systemic inflammatory response syndrome. We compared histidine-rich glycoprotein, procalcitonin, and presepsin levels to assess their significance as biomarkers. DESIGN: Single-center, prospective, observational cohort study. SETTING: ICU at an university-affiliated hospital...
January 4, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29291203/do-you-want-to-participate-in-a-clinical-study-as-a-healthy-control-risk-or-benefit
#16
Hanna Giessen, Christian A Nebiker, Matthias Bruehlmeier, Stefan Spreitzer, Beat Mueller, Philipp Schuetz
A healthy woman volunteered to participate as "healthy control" in a study. An increased level of procalcitonin (PCT) was detected and remained elevated on follow-up measurements. As calcitonin levels were elevated as well, thyroid ultrasound was performed which revealed nodes in both thyroid lobes, one of them showing metabolic activity in positron emission tomography-computed tomography scan. To exclude a malignant thyroid cancer despite the negative findings in a fine needle aspiration the patient underwent thyroidectomy and a medullary thyroid carcinoma (MTC) was detected in the right lobe...
December 16, 2017: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/29290765/inflammatory-response-and-toxicity-after-pressurized-intraperitoneal-aerosol-chemotherapy
#17
Hugo Teixeira Farinha, Fabian Grass, Ismaïl Labgaa, Basile Pache, Nicolas Demartines, Martin Hübner
Background: Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) is a novel mode of intraperitoneal (IP) drug delivery claiming high IP tissue concentrations with low systemic uptake. The aim was to study inflammatory response and systemic toxicity after PIPAC. Methods: Retrospective monocentric analysis of a consecutive cohort of PIPAC patients between January 2015 and April 2016. Detailed hematological and biochemical analysis was performed the day before surgery and once daily until discharge. Comparative statistics were performed using Mann-Whitney U test and Wilcoxon signed ranked test...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29290660/efficacy-of-noninvasive-evaluations-in-monitoring-inflammatory-bowel-disease-activity-a-prospective-study-in-china
#18
Jin-Min Chen, Tao Liu, Shan Gao, Xu-Dong Tong, Fei-Hong Deng, Biao Nie
AIM: To optimize the efficacy of noninvasive evaluations in monitoring the endoscopic activity of inflammatory bowel disease (IBD). METHODS: Fecal calprotectin (FC), clinical activity index (CDAI or CAI), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and procalcitonin (PCT) were measured for 136 IBD patients. Also, FC was measured in 25 irritable bowel syndrome (IBS) patients that served as controls. Then, endoscopic activity was determined by other two endoscopists for colonic or ileo-colonic Crohn's disease (CICD) with the "simple endoscopic score for Crohn's disease" (SES-CD), CD-related surgery patients with the Rutgeerts score, and ulcerative colitis (UC) with the Mayo score...
December 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29289378/prognostic-power-of-biomarkers-for-short-term-mortality-in-the-elderly-patients-seen-in-emergency-departments-due-to-infections
#19
Agustín Julián-Jiménez, María Cecilia Yañez, Juan González-Del Castillo, Manuel Salido-Mota, Begoña Mora-Ordoñez, María Jesús Arranz-Nieto, Manuel R Chanovas-Borras, Ferrán Llopis-Roca, Josep María Mòdol-Deltell, Gema Muñoz
OBJECTIVES: To analyse and compare 30-day mortality prognostic power of several biomarkers (C-reactive protein, procalcitonin, lactate, suPAR and pro-adremomedullin) in elderly patients seen in Emergency Departments (ED) due to infections. Secondly, if these could improve the prognostic accuracy of sepsis criteria (systemic inflammatory response syndrome and quick Sepsis-related Organ Failure Assessment [qSOFA]). METHODS: A prospective, observational, multicentre and analytical study...
December 27, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/29287292/procalcitonin-as-predictor-of-bacterial-infection-in-meconium-aspiration-syndrome
#20
Mahendiran K, Prerna Batra, M M A Faridi, N P Singh
BACKGROUND:  There is a lack of definite consensus on indications for initiating antibiotics in neonates with meconium aspiration syndrome (MAS), instigating researchers to search for a biomarker that can help differentiate MAS from MAS with bacterial infection. OBJECTIVE:  Our primary objective was to compare serum procalcitonin (PCT) levels in full-term vigorous neonates having MAS with or without bacterial infection. MATERIALS AND METHODS:  Seventy term vigorous neonates with diagnosis of MAS were enrolled...
December 29, 2017: American Journal of Perinatology
keyword
keyword
2159
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"