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https://www.readbyqxmd.com/read/28079629/duration-of-pneumonia-therapy-and-the-role-of-biomarkers
#1
Katerina Kaziani, Adamantia Sotiriou, George Dimopoulos
PURPOSE OF REVIEW: Increasing antimicrobial resistance is a worldwide phenomenon that is threatening public health. Lower respiratory infections are one of the leading causes of morbidity that contribute to antibiotic consumption and thus the emergence of multidrug-resistant microbial strains. The goal of shortening antibiotic regimens' duration in common bacterial infections has been prioritized by antimicrobial stewardship programs as an action against this problem. RECENT FINDINGS: Data coming from randomized controlled trials, meta-analyses, and systematic reviews support the shortening of antimicrobial regimens in community-acquired, hospital-acquired, and ventilator-associated pneumonia...
January 12, 2017: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/28079172/25-oh-d-and-1-25-oh-d-vitamin-d-fails-to-predict-sepsis-and-mortality-in-a-prospective-cohort-study
#2
Franz Ratzinger, Helmuth Haslacher, Markus Stadlberger, Ralf L J Schmidt, Markus Obermüller, Klaus G Schmetterer, Thomas Perkmann, Athanasios Makristathis, Rodrig Marculescu, Heinz Burgmann
The clinical role of vitamin D in sepsis and mortality prediction is controversially discussed. Therefore, we conducted a prospective cohort study on standard care wards, including 461 patients with suspected sepsis fulfilling two or more SIRS criteria. On the first and third day after onset of SIRS symptoms levels of 25(OH)D, 1,25(OH)D and sepsis biomarkers were analysed for their predictive capacity for identifying infection, bacteraemia and an elevated mortality risk. Additionally, several SNPs associated with vitamin D metabolism were evaluated...
January 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28076309/activation-of-the-tryptophan-serotonin-pathway-is-associated-with-severity-and-predicts-outcomes-in-pneumonia-results-of-a-long-term-cohort-study
#3
Marc A Meier, Manuel Ottiger, Alaadin Vögeli, Christian Steuer, Luca Bernasconi, Robert Thomann, Mirjam Christ-Crain, Christoph Henzen, Claus Hoess, Werner Zimmerli, Andreas Huber, Beat Mueller, Philipp Schuetz
BACKGROUND: As part of the immune defense during infection, an increase in enzyme activity of indoleamine 2,3-dioxygenase (IDO) leads to a breakdown of tryptophan to kynurenine. In previous animal studies, therapeutic antagonism of IDO resulted in reduced sepsis mortality. We investigated the prognostic ability of tryptophan, serotonin, kynurenine and IDO (represented by the ratio of kynurenine/tryptophan) to predict adverse clinical outcomes in patients with community-acquired pneumonia (CAP)...
January 11, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28065252/additional-real-world-evidence-supporting-procalcitonin-as-an-effective-tool-to-improve-antibiotic-management-and-cost-of-the-critically-ill-patient
#4
EDITORIAL
Philipp Schuetz, Peter M Wahl
No abstract text is available yet for this article.
January 2017: Chest
https://www.readbyqxmd.com/read/28064278/is-procalcitonin-really-useful-for-diagnosis-and-prognosis-of-copd-exacerbations-requiring-mechanical-ventilation
#5
Matteo Giorgi-Pierfranceschi, João Cravo, Francesco Dentali, Antonio M Esquinas
No abstract text is available yet for this article.
January 7, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/28056911/prospective-cohort-study-of-procalcitonin-levels-in-children-with-cancer-presenting-with-febrile-neutropenia
#6
Victoria Hemming, Adam D Jakes, Geoff Shenton, Bob Phillips
BACKGROUND: Febrile neutropenia (FNP) causes significant morbidity and mortality in children undergoing treatment for cancer. The development of clinical decision rules to help stratify risks in paediatric FNP patients and the use of inflammatory biomarkers to identify high risk patients is an area of recent research. This study aimed to assess if procalcitonin (PCT) levels could be used to help diagnose or exclude severe infection in children with cancer who present with febrile neutropenia, both as a single measurement and in addition to previously developed clinical decision rules...
January 5, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28054289/procalcitonin-is-a-poor-predictor-of-non-infectious-fever-in-the-neurocritical-care-unit
#7
Karin Halvorson, Sameer Shah, Corey Fehnel, Bradford Thompson, N Stevenson Potter, Mitchell Levy, Linda Wendell
BACKGROUND: Fever is a common occurrence in the Neurocritical Care Unit (NCCU). It is reported that up to 50 % of these fevers are associated with a non-infectious source. As this is a diagnosis of exclusion, a complete fever evaluation must be done to rule out infection. Procalcitonin (PCT) has been identified as a possible biomarker to distinguish infectious from non-infectious etiologies of fever. We hypothesized that PCT could be used as a predictor of infectious fever in febrile patients with intracranial hemorrhage admitted to the NCCU...
January 4, 2017: Neurocritical Care
https://www.readbyqxmd.com/read/28051279/carotid-intima-media-thickness-and-blood-biomarkers-of-atherosclerosis-in-patients-after-stroke-or-myocardial-infarction
#8
Iwona Kurkowska-Jastrzebska, Michał A Karlinski, Beata Błazejewska-Hyzorek, Iwona Sarzynska-Dlugosz, Krzysztof J Filipiak, Anna Czlonkowska
AIM: To test if circulating levels of markers of inflammation, endothelial function, and chronic infections, as well as association between these markers and carotid intima media thickness (CIMT), depend on the stage of atherosclerosis expressed as a history of a major vascular event. METHODS: The associations were analyzed separately in 75 healthy controls, 79 patients 3-6 months after the first-ever non-cardioembolic ischemic stroke (IS), and 37 patients 3-6 months after the first-ever myocardial infarction (MI)...
December 31, 2016: Croatian Medical Journal
https://www.readbyqxmd.com/read/28045978/cord-blood-acute-phase-reactants-predict-early-onset-neonatal-sepsis-in-preterm-infants
#9
Leena B Mithal, Hannah L Palac, Ram Yogev, Linda M Ernst, Karen K Mestan
BACKGROUND: Early onset sepsis (EOS) is a major cause of morbidity and mortality in preterm infants, yet diagnosis remains inadequate resulting in missed cases or prolonged empiric antibiotics with adverse consequences. Evaluation of acute phase reactant (APR) biomarkers in umbilical cord blood at birth may improve EOS detection in preterm infants with intrauterine infection. METHODS: In this nested case-control study, infants (29.7 weeks gestation, IQR: 27.7-32...
2017: PloS One
https://www.readbyqxmd.com/read/28040383/acute-care-diagnostic-collaboration-bayesian-modeling-comparative-diagnostic-assessment-of-lactate-procalcitonin-and-crp-in-risk-stratified-population-by-mortality-in-emergency-department-meds-score
#10
Laila Cochon, Anais Ovalle, José M Nicolás, Amado Alejandro Baez
OBJECTIVE: To assess and compare the diagnostic value of lactate, procalcitonin (PCT) and C-reactive protein (CRP) in low, moderate, and high-risk stratified population applying Mortality in Emergency Department (MEDS) risk score using Bayesian statistical modeling. METHODS: MEDS criteria was used to risk stratify into low, moderate and high risk. Each population was attributed a percentage risk, and used as pre-test probability in the Bayesian nomogram. Sensitivity and specificity lactate, PCT and CRP were attained from pooled meta-analysis data...
December 19, 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28039586/plasma-phospholipid-fatty-acid-profile-is-altered-in-both-septic-and-non-septic-critically-ill-a-correlation-with-inflammatory-markers-and-albumin
#11
František Novak, J Borovska, M Vecka, J Rychlikova, L Vavrova, H Petraskova, A Zak, O Novakova
This study analyzes fatty acid (FA) composition in plasma lipids and erythrocyte phospholipids while comparing septic and non-septic critically ill patients. The aim was to describe impacts of infection and the inflammatory process. Patients with severe sepsis (SP, n = 13); age-, sex- and APACHE II score-matched non-septic critically ill with systemic inflammatory response syndrome (NSP, n = 13); and age-/sex-matched healthy controls (HC, n = 13) were included in a prospective case-control study during the first 24 h after admission to the intensive care unit...
December 30, 2016: Lipids
https://www.readbyqxmd.com/read/28038785/reduced-thrombin-activatable-fibrinolysis-inhibitor-and-enhanced-proinflammatory-cytokines-in-acute-coronary-syndrome
#12
H Pang, C Zhang, F Liu, X Gong, X Jin, C Su
OBJECTIVE: A study was made of the changes in the serum levels of thrombin activatable fibrinolysis inhibitor (TAFI), proinflammatory cytokines and acute phase proteins in the acute stage of acute coronary syndrome (ACS), in order to explore the possibility of using TAFI as a biomarker for ACS risk assessment. METHODS: A total of 211 patients with ACS were enrolled, and healthy subjects were used as controls. Blood samples were taken within 24h after admission. Serum TAFI levels were determined by immunoturbidimetry...
December 27, 2016: Medicina Intensiva
https://www.readbyqxmd.com/read/28034667/adjunctive-hyperbaric-oxygen-therapy-in-severe-burns-experience-in-taiwan-formosa-water-park-dust-explosion-disaster
#13
I-Han Chiang, Shyi-Gen Chen, Kun-Lun Huang, Yu-Ching Chou, Niann-Tzyy Dai, Chung-Kan Peng
BACKGROUND: Despite major advances in therapeutic strategies for the management of patients with severe burns, significant morbidity and mortality is observed. Hyperbaric oxygen therapy (HBOT) increases the supply of oxygen to burn areas. The aim of this study was to determine whether HBOT is effective in the treatment of major thermal burns. METHODS: On June 27, 2015 in New Taipei, Taiwan, a mass casualty disaster occurred as fire erupted over a large crowd, injuring 499 people...
December 26, 2016: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28030737/procalcitonin-guided-antimicrobial-therapy-all-about-the-algorithm-reply
#14
Konrad Reinhart, Frank Bloos
No abstract text is available yet for this article.
January 1, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28030733/procalcitonin-guided-antimicrobial-therapy-all-about-the-algorithm
#15
Jos A H van Oers, Maarten W Nijsten, Armand R Girbes
No abstract text is available yet for this article.
January 1, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28028489/biomarkers-for-diagnosis-of-sepsis-in-patients-with-systemic-inflammatory-response-syndrome-a-systematic-review-and-meta-analysis
#16
Yong Liu, Jun-Huan Hou, Qing Li, Kui-Jun Chen, Shu-Nan Wang, Jian-Min Wang
BACKGROUND: Sepsis is one of the most common diseases that seriously threaten human health. Although a large number of markers related to sepsis have been reported in the last two decades, the diagnostic accuracy of these biomarkers remains unclear due to the lack of similar baselines among studies. Therefore, we conducted a large systematic review and meta-analysis to evaluate the diagnostic value of biomarkers from studies that included non-infectious systemic inflammatory response syndrome patients as a control group...
2016: SpringerPlus
https://www.readbyqxmd.com/read/28024740/impact-of-procalcitonin-guided-therapy-for-hospitalized-community-acquired-pneumonia-on-reducing-antibiotic-consumption-and-costs-in-japan
#17
Akihiro Ito, Tadashi Ishida, Hironobu Tokumasu, Yasuyoshi Washio, Akio Yamazaki, Yuhei Ito, Hiromasa Tachibana
BACKGROUND AND OBJECTIVE: This study aimed to investigate the usefulness of procalcitonin-guided therapy in hospitalized community-acquired pneumonia patients to reduce antibiotic duration and costs without worsening prognosis. METHODS: 352 hospitalized community-acquired pneumonia patients in an observational cohort study in which procalcitonin was measured three times serially, on admission (Day 1) and 2-3 days (Day 3) and 6-8 days (Day 7) after admission, between October 2010 and February 2016 were reviewed retrospectively...
December 23, 2016: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28010128/procalcitonin-for-clinical-decisions-on-influenza-like-illness-in-emergency-department-during-influenza-a-h1n1-2009-pandemic
#18
P Canavaggio, D Boutolleau, H Goulet, B Riou, P Hausfater
PURPOSE: We aimed to determine whether serum PCT values could help in identifying flu in patient admitted to the emergency department (ED) with influenza-like illness during influenza A(H1N1)2009 pandemic. METHODS: An observational retrospective cohort study was performed in a referral ED for emerging infectious diseases. All patients tested for influenza A(H1N1)2009 by RT-PCR and procalcitonin between June 2009 and January 2010 were analyzed. PCT was studied for its negative predictive value of bacterial infection...
December 23, 2016: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28005932/the-use-of-procalcitonin-pct-for-diagnosis-of-sepsis-in-burn-patients-a-meta-analysis
#19
Luís Cabral, Vera Afreixo, Luís Almeida, José Artur Paiva
The continuous development of resuscitation techniques and intensive care reduced the mortality rate induced by the initial shock in burn patients and, currently, infections (especially sepsis) are the main causes of mortality of these patients. The misuse of antimicrobial agents is strongly related to antimicrobial and adverse patient outcomes, development of microbial resistance and increased healthcare-related costs. To overcome these risks, antimicrobial stewardship is mandatory and biomarkers are useful to avoid unnecessary medical prescription, to monitor antimicrobial therapy and to support the decision of its stop...
2016: PloS One
https://www.readbyqxmd.com/read/28002647/il-7-and-procalcitonin-are-useful-biomarkers-in-the-comprehensive-evaluation-of-the-severity-of-acute-cholangitis
#20
Yusuke Suwa, Ryusei Matsuyama, Koki Goto, Toshiaki Kadokura, Mari Sato, Ryutaro Mori, Takafumi Kumamoto, Masataka Taguri, Taku Miyasho, Itaru Endo
BACKGROUND: The incidence of biliary tract infection (BTI), especially healthcare-associated cholangitis, is increasing. However, there are few reports concerning biomarkers of acute cholangitis. We therefore performed an exhaustive investigation of several biomarkers. METHODS: We retrospectively measured eleven cytokines, six chemokines and procalcitonin (PCT), and endotoxin activity assay (EAA) values (IRB: 110512019) of sixty-one samples with acute cholangitis...
December 21, 2016: Journal of Hepato-biliary-pancreatic Sciences
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