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https://www.readbyqxmd.com/read/29168170/platelets-derived-from-fresh-and-cold-stored-whole-blood-participate-in-clot-formation-in-rats-with-acute-traumatic-coagulopathy
#1
Xiaowu Wu, Daniel N Darlington, Robbie K Montgomery, Bin Liu, Jeffrey D Keesee, Michael R Scherer, Avi Benov, Jacob Chen, Andrew P Cap
The in vitro haemostatic functions of fresh whole blood (FWB) are well preserved after cold storage. This study aimed to determine whether platelets derived from FWB and stored whole blood (SWB) contribute to clot formation in tissue injury after transfusion into coagulopathic rats with polytrauma/haemorrhage (T/H). The rats were resuscitated 1 h after trauma with FWB or SWB collected from green fluorescence protein (GFP) transgenic rats. After transfusion, a liver incision was made and the tissue was collected 10 min after injury to identify GFP(+) platelets by immunohistochemistry...
November 22, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/29168168/the-value-of-cold-storage-whole-blood-platelets-in-trauma-resuscitation-is-like-real-estate-a-function-of-location-location-location
#2
EDITORIAL
Mark Walsh, Jacob Shreve, Scott Thomas
No abstract text is available yet for this article.
November 22, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/29167910/easy-to-learn-cardiopulmonary-resuscitation-training-programme-a-randomised-controlled-trial-on-laypeople-s-resuscitation-performance
#3
Rachel Jia Min Ko, Swee Han Lim, Vivien Xi Wu, Tak Yam Leong, Sok Ying Liaw
INTRODUCTION: Simplifying the learning of cardiopulmonary resuscitation (CPR) is advocated to improve skill acquisition and retention. A simplified CPR training programme focusing on continuous chest compression, with a simple landmark tracing technique, was introduced to laypeople. The study aimed to examine the effectiveness of the simplified CPR training in improving lay rescuers' CPR performance as compared to standard CPR. METHODS: 85 laypeople (aged 21-60 years) were recruited and randomly assigned to undertake either a two-hour simplified CPR training or standard CPR training...
November 13, 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/29167861/ultrasonographic-guided-resuscitation-of-the-surgical-patient
#4
Asanthi Ratnasekera, Paula Ferrada
No abstract text is available yet for this article.
November 22, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/29167495/changes-in-cardiac-arrest-patients-temperature-management-after-the-publication-of-2015-aha-guidelines-for-resuscitation-in-china
#5
Lanfang Du, Baolan Ge, Qingbian Ma, Jianzhong Yang, Fengying Chen, Yuhong Mi, Huadong Zhu, Cong Wang, Yan Li, Hongbo Zhang, Rongjia Yang, Jian Guan, Yixiong Zhang, Guiyun Jin, Haiyan Zhu, Yan Xiong, Guoxing Wang, Zhengzhong Zhu, Haiyan Zhang, Yun Zhang, Jihong Zhu, Jie Li, Chao Lan, Hui Xiong
A survey was performed to assess the current management of targeted temperature management (TTM) in patients following cardiac arrest (CA) and whether healthcare providers will change target temperature after publication of 2015 American Heart Association guidelines for resuscitation in China. 52 hospitals were selected from whole of China between August to November 2016. All healthcare providers in EMs and/or ICUs of selected hospitals participated in the study. 1952 respondents fulfilled the survey (86.8%)...
November 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29166922/herpes-simplex-type-1-pneumonitis-and-acute-respiratory-distress-syndrome-in-a-patient-with-chronic-lymphatic-leukemia-a-case-report
#6
Miriam Luginbuehl, Alexander Imhof, Alexander Klarer
BACKGROUND: Pulmonary pathogenicity of herpes simplex virus type 1 in patients in intensive care without classic immunosuppression as well as the necessity of antiviral treatment in the case of herpes simplex virus detection in respiratory specimens in these patients is controversial. We present a case of acute respiratory distress syndrome in a patient with stable chronic lymphatic leukemia not requiring treatment, in whom we diagnosed herpes simplex virus type 1 bronchopneumonitis based on herpes simplex virus type 1 detection in bronchoalveolar lavage fluid and clinical response to antiviral treatment...
November 23, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29166709/-effects-of-dexmedetomidine-on-myocardium-of-rats-with-severe-burn-at-early-stage
#7
D Wang, P L Yang, X Zhang, Y Liu
Objective: To investigate the effects of dexmedetomidine on myocardium of rats at early stage after severe burn. Methods: Twenty specific pathogen free male SD rats were immersed in 90 ℃ hot water for 20 s, causing 30% total body surface area (TBSA) full-thickness scald (hereafter referred to as burn) on the back. And then they were divided into burn resuscitation group (BR) and burn resuscitation+ dexmedetomidine group (BRD) according to the random number table, with 10 rats in each group. Sodium lactate Ringer's solution (2 mL·kg(-1)·%TBSA(-1)) were intraperitoneally injected into rats of both groups after burn...
November 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/29166296/emergency-intubations-in-a-high-volume-pediatric-emergency-department
#8
Jen Heng Pek, Gene Yong-Kwang Ong
INTRODUCTION: Resuscitation of critically ill children can be chaotic, and emergency airway management is often fraught with difficulties. This study aimed to characterize the Singaporean landscape of tracheal intubation in a pediatric emergency unit, placing emphasis on safety outcomes, procedural process of care, and provider training. METHODS: A retrospective review of all cases presented to the KK Women's and Children's Hospital from January 2009 to December 2013 with intubation carried out within the pediatric emergency unit was done...
November 21, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29165155/association-between-high-and-low-ambient-temperature-and-out-of-hospital-cardiac-arrest-with-cardiac-etiology-in-japan-a-case-crossover-study
#9
Shin Yamazaki, Takehiro Michikawa
OBJECTIVE: The objective of the study was to examine the association between high and low temperature and out-of-hospital cardiac arrest (OHCA) with cardiac etiology. METHODS: The study was conducted under a case-crossover design. Subjects were 97,500 patients aged 40 years or older with OHCA having a cardiac etiology in Tokyo, Osaka, and Fukuoka Prefecture from 2005 to 2012. We used national data with an Utstein-style resuscitation registration. Temperature was categorized into five categories with cut points of 5, 10, 24, and 30 °C...
July 13, 2017: Environmental Health and Preventive Medicine
https://www.readbyqxmd.com/read/29163940/sub-minimum-inhibitory-concentration-of-rifampin-a-potential-risk-factor-for-resuscitation-of-mycobacterium-tuberculosis
#10
Shahin Pourazar Dizaji, Alireza Taala, Morteza Masoumi, Nayereh Ebrahimzadeh, Abolfazl Fateh, Seyed Davar Siadat, Farzam Vaziri
Background: Mycobacterium tuberculosis possesses five resuscitation-promoting factors, Rpf A to E, which are required for the resuscitation of dormancy in mycobacteria. This study explores the transcriptional profile of all five rpfs of M. tuberculosis, in response to sub-MIC concentration of rifampin, in multidrug and mono-rifampin resistant clinical isolates. Methods: Thirteen multidrug and two rifampin mono resistant clinical isolates were analyzed. Drug susceptibility testing and determination of MIC were performed...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29162766/production-and-rearing-of-germ-free-x-scid-pigs
#11
Hiromasa Hara, Hiroaki Shibata, Kazuaki Nakano, Tomoyuki Abe, Hideki Uosaki, Takahiro Ohnuki, Shuji Hishikawa, Satoshi Kunita, Masahito Watanabe, Osamu Nureki, Hiroshi Nagashima, Yutaka Hanazono
Pigs with X-linked severe combined immunodeficiency (X-SCID) caused by a mutation of the interleukin-2 receptor gamma chain gene (IL2RG) are of value for a wide range of studies. However, they do not survive longer than 8 weeks because of their susceptibility to infections. To allow longer survival of X-SCID pigs, the animals must be born and reared under germ-free conditions. Here, we established an efficient system for piglet derivation by hysterectomy and used it to obtain and maintain a germ-free X-SCID pig...
November 21, 2017: Experimental Animals
https://www.readbyqxmd.com/read/29162573/data-quality-and-30-day-survival-for-out-of-hospital-cardiac-arrest-in-the-uk-out-of-hospital-cardiac-arrest-registry-a-data-linkage-study
#12
Sangeerthana Rajagopal, Scott J Booth, Terry P Brown, Chen Ji, Claire Hawkes, A Niroshan Siriwardena, Kim Kirby, Sarah Black, Robert Spaight, Imogen Gunson, Samantha J Brace-McDonnell, Gavin D Perkins
OBJECTIVES: The Out-of-Hospital Cardiac Arrest Outcomes (OHCAO) project aims to understand the epidemiology and outcomes of out-of-hospital cardiac arrest (OHCA) across the UK. This data linkage study is a subproject of OHCAO. The aim was to establish the feasibility of linking OHCAO data to National Health Service (NHS) patient demographic data and Office for National Statistics (ONS) date of death data held on the NHS Personal Demographics Service (PDS) database to improve OHCAO demographic data quality and enable analysis of 30-day survival from OHCA...
November 20, 2017: BMJ Open
https://www.readbyqxmd.com/read/29162440/automated-external-defibrillators-in-the-hospital-a-case-of-medical-reversal
#13
John A Stewart
Automated external defibrillators (AEDs) emerged in the 1980s as an important innovation in pre-hospital emergency cardiac care (ECC). In the years since, the American Heart Association (AHA) and the International Liaison Committee for Resuscitation (ILCOR) have promoted AED technology for use in hospitals as well, resulting in the widespread purchase and use of AED-capable defibrillators. In-hospital use of AEDs now appears to have decreased survival from cardiac arrests. This article will look at the use of AEDs in hospitals as a case of "medical reversal...
November 18, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29162438/peri-intubation-factors-affecting-emergency-physician-choice-of-paralytic-agent-for-rapid-sequence-intubation-of-trauma-patients
#14
Jason R West, Catherine Lott, Lee Donner, Marc Kanter, Nicholas D Caputo
INTRODUCTION: No study has assessed predictors of physician choice between the succinylcholine (Succ) and rocuronium (Roc) for rapid sequence intubation (RSI) during the initial resuscitation of trauma patients in the emergency department (ED). METHODS: We retrospectively evaluated of the use of Succ and Roc for adult trauma patients undergoing RSI at a Level 1 trauma center. The primary outcome was to identify factors affecting physician choice of paralytic agent for RSI analyzed by cluster analysis using pre-intubation vital signs and early mortality...
November 18, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29162266/plasma-free-carnitine-in-severe-trauma-influence-of-the-association-with-traumatic-brain-injury
#15
Fanny Vardon Bounes, Géraldine Faure, Antoine Rouget, Jean-Marie Conil, Bernard Georges, Thomas Geeraerts, Olivier Fourcade, Vincent Minville, Clément Delmas
BACKGROUND: Metabolic response to severe trauma requires early nutritional resuscitation. Carnitine is essential for lipolysis, the energy source during this hypercatabolic phase. However l-carnitine is not present in nutritional replacement solutions. Furthermore, free carnitine depletion, defined as carnitine plasma level under 36μmol/L, was not adequately reported in adult patients with severe trauma. The aim of this study was to assess plasma free carnitine levels and factors of variation in severe trauma...
November 15, 2017: Injury
https://www.readbyqxmd.com/read/29159800/effects-of-combined-helium-pre-post-conditioning-on-the-brain-and-heart-in-a-rat-resuscitation-model
#16
C Aehling, N C Weber, C J Zuurbier, B Preckel, R Galmbacher, K Stefan, M W Hollmann, E Popp, J Knapp
BACKGROUND: The noble gas helium induces cardio- and neuroprotection by pre- and post-conditioning. We investigated the effects of helium pre- and post-conditioning on the brain and heart in a rat resuscitation model. METHODS: After approval by the Animal Care Committee, 96 Wistar rats underwent cardiac arrest for 6 min induced by ventricular fibrillation. Animals received 70% helium and 30% oxygen for 5 min before cardiac arrest and for 30 min after restoration of spontaneous circulation (ROSC)...
November 20, 2017: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/29159371/care-planning-for-inpatients-referred-for-palliative-care-consultation
#17
Kara Bischoff, David L O'Riordan, Angela K Marks, Rebecca Sudore, Steven Z Pantilat
Importance: Care planning is a critical function of palliative care teams, but the impact of advance care planning and goals of care discussions by palliative care teams has not been well characterized. Objective: To describe the population of patients referred to inpatient palliative care consultation teams for care planning, the needs identified by palliative care clinicians, the care planning activities that occur, and the results of these activities. Design, Setting, and Participants: This was a prospective cohort study conducted between January 1, 2013, and December 31, 2016...
November 20, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/29159010/multiple-myeloma-presenting-as-acute-renal-failure-in-the-absence-of-other-characteristic-features
#18
Zachary N Gastelum, Diana M Biggs, Aaron Scott
This case report describes a 54-year-old, asymptomatic man who presented with hyperkalemia on routine lab testing who was later found to have acute renal failure, unresponsive to fluid resuscitation, with minimal improvement after hemodialysis. After a comprehensive evaluation ruled out common causes of acute renal failure, the patient underwent testing with a bone survey, urine protein electrophoresis (UPEP), serum protein electrophoresis (SPEP), and immunoelectrophoresis for suspected plasma cell dyscrasia and received plasmapheresis for hyperviscosity syndrome and nephrotoxicity, which resulted in improved renal function...
September 20, 2017: Curēus
https://www.readbyqxmd.com/read/29158921/a-nearly-lethal-screw-an-unusual-cause-of-recurrent-bradycardia-and-asystole-episodes-after-fixation-of-the-cervical-spine
#19
Amit Frenkel, Yair Binyamin, Evgeni Brotfain, Leonid Koyfman, Aviel Roy-Shapira, Ilan Shelef, Moti Klein
We present a case of a 51-year-old man who was injured in a bicycle accident. His main injury was an unstable fracture of the cervical and thoracic vertebral column. Several hours after his arrival to the hospital the patient underwent open reduction and internal fixation (ORIF) of the cervical and thoracic spine. The patient was hospitalized in our critical care unit for 99 days. During this time patient had several episodes of severe bradycardia and asystole; some were short with spontaneous return to sinus and some required pharmacological treatment and even Cardiopulmonary Resuscitation (CPR)...
2017: Case Reports in Critical Care
https://www.readbyqxmd.com/read/29158865/-anesthesiological-aspects-and-complications-of-intracranial-meningiomas-operated-at-the-sylvanus-olympio-university-hospital-center-lom%C3%A3-about-21-cases
#20
Pilakimwé Egbohou, Tabana Mouzou, Kadanga Beketi, Essossinam Kpelao, Abdel Kader Moumouni, Hamza Doles Sama, Sarakawabalo Assénouwé, Gnimdou Akala-Yoba, Kadjika Tomta
This study aimed to point to both the anesthesiological aspects and the perioperative complications of intracranial meningiomas operated at the Sylvanus Olympio University Hospital Center, Lomé. We conducted a retrospective study by reviewing the medical records of patients with intracranial meningiomas undergoing surgery over the period December 2010-December 2015 (5 years) at the Sylvanus Olympio University Hospital Center, Lomé. Out of 46 patients operated fo brain tumors, 21 (45.6%) had meningioma. The average age was 49 ±20 years, with a male predominance (52...
2017: Pan African Medical Journal
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