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https://www.readbyqxmd.com/read/29788943/profiling-non-tuberculous-mycobacteria-in-an-asian-setting-characteristics-and-clinical-outcomes-of-hospitalized-patients-in-singapore
#1
Albert Y H Lim, Sanjay H Chotirmall, Eric T K Fok, Akash Verma, Partha P De, Soon Keng Goh, Ser Hon Puah, Daryl E L Goh, John A Abisheganaden
BACKGROUND: Non-tuberculous mycobacteria (NTM) infection is an increasing problem worldwide. The epidemiology of NTM in most Asian countries is unknown. This study investigated the epidemiology, and clinical profile of inpatients in whom NTM was isolated from various anatomical sites in a Singaporean population attending a major tertiary referral centre. METHODS: Demographic profile, clinical data, and characteristics of patients hospitalized with NTM isolates at a major tertiary hospital over two-year period were prospectively assessed (2011-2012)...
May 22, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29773092/preliminary-study-on-drug-susceptibility-profile-and-resistance-mechanisms-to-macrolides-of-clinical-isolates-of-non-tuberculous-mycobacteria-from-china
#2
Fu Li, Gui Lian Li, Hui Pang, Hai Can Liu, Tong Yang Xiao, Shuang Jun Li, Qiao Luo, Yi Jiang, Rui Bai Wang, Kang Lin Wan
OBJECTIVE: Macrolide susceptibility and drug resistance mechanisms of clinical non-tuberculous mycobacteria (NTM) isolates were preliminarily investigated for more accurate diagnosis and treatment of the infection in China. METHODS: Four macrolides, including clarithromycin (CLAR), azithromycin (AZM), roxithromycin (ROX), and erythromycin (ERY), were used to test the drug susceptibility of 310 clinical NTM isolates from six provinces of China with the broth microdilution method...
April 2018: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29772918/cutaneous-nontuberculous-mycobacterial-infections-in-alberta-canada-an-epidemiologic-study-and-review
#3
Megan A Sander, Judith L Isaac-Renton, Gregory J Tyrrell
BACKGROUND: Cutaneous infections caused by nontuberculous mycobacteria (NTM) occur infrequently. Nonetheless, the incidence of NTM infections is reported to be increasing. In Canada, cutaneous NTM infections have not been well described. OBJECTIVES: A database review from 2006 to 2016 was done to assess species frequency, incidence, and trends of the most common cutaneous NTMs in the province of Alberta, Canada. We also reviewed major diagnostic and epidemiologic aspects of NTM cutaneous infections with a focus on Mycobacterium marinum...
May 1, 2018: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29760127/-in-vitro-activity-of-clofazimine-against-non-tuberculous-mycobacteriaisolated-in-beijing-china
#4
Jingjing Luo, Xia Yu, Guanglu Jiang, Yuhong Fu, Fengmin Huo, Yifeng Ma, Fen Wang, Yuanyuan Shang, Qian Liang, Yi Xue, Hairong Huang
Due to the natural resistance of non-tuberculous mycobacteria(NTM) to lots of antibiotics,treatment of diseases caused by NTM is often long-termed but less successful.The main goal of this study was to evaluate the in vitro susceptibility to clofazimine of 209 isolates consisting of different NTM species isolated in Beijing,China. Furthermore,47 reference strains were also tested, including 30 rapidly growing mycobacterium (RGM) species and 17 slowly growing mycobacterium(SGM) species.The potential molecular mechanism contributing to clofazimine resistance of NTM was investigated as well...
May 14, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29674548/draft-genome-sequence-of-mycobacterium-porcinum-csurp1564
#5
A Bouam, A Levasseur, M Drancourt
Mycobacterium porcinum is a rapidly growing environmental mycobacterium responsible for opportunistic infections. The 7,025,616-bp draft genome of M. porcinum strain CSURP1564 exhibits a 66.71% G+C content, 6,687 protein-coding genes, and 65 predicted RNA genes. In silico DNA-DNA hybridization confirms its assignment to the Mycobacterium fortuitum complex.
April 19, 2018: Genome Announcements
https://www.readbyqxmd.com/read/29643203/evaluation-of-the-vitek-ms-v3-0-matrix-assisted-laser-desorption-ionization-time-of-flight-mass-spectrometry-system-for-identification-of-mycobacterium-and-nocardia-species
#6
Barbara A Body, Melodie A Beard, E Susan Slechta, Kimberly E Hanson, Adam P Barker, N Esther Babady, Tracy McMillen, Yi-Wei Tang, Barbara A Brown-Elliott, Elena Iakhiaeva, Ravikiran Vasireddy, Sruthi Vasireddy, Terry Smith, Richard J Wallace, S Turner, L Curtis, Susan Butler-Wu, Jenna Rychert
This multi-center study was designed to assess the accuracy and reproducibility of the VITEK MS v3.0 matrix-assisted laser desorption ionization--time of flight (MALDI-TOF) mass spectrometry system for identification of Mycobacterium and Nocardia species compared to DNA sequencing. A total of 963 clinical isolates representing 51 taxa were evaluated. In all, 663 isolates were correctly identified to the species level (69%) with another 231 (24%) correctly identified to the complex or group level. Fifty-five isolates (6%) could not be identified despite repeat testing...
April 11, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29570764/atypical-mycobacterial-infections-of-the-upper-extremity
#7
Kevin P Smidt, Peter J Stern, Thomas R Kiefhaber
Atypical mycobacterial infections of upper extremity synovial-lined structures are often misdiagnosed and unrecognized. Despite an increasing incidence, lack of physician awareness of these pathogens may result in considerable delay in diagnosis and management, potentially leading to permanent disability. The authors conducted a literature review and analyzed 31 cases of penetrating atypical mycobacterial infection to better understand the clinical characteristics and to evaluate their posttreatment complication rate compared with available literature...
March 23, 2018: Orthopedics
https://www.readbyqxmd.com/read/29563276/non-tuberculous-mycobacterial-infections-related-to-peritoneal-dialysis
#8
Hiroyuki Inoue, Naoki Washida, Kohkichi Morimoto, Keisuke Shinozuka, Takahiro Kasai, Kiyotaka Uchiyama, Hirobumi Tokuyama, Shu Wakino, Hiroshi Itoh
Most infections related to peritoneal dialysis (PD) are caused by common bacteria, and non-tuberculous mycobacteria are rare. The clinical characteristics and prognosis of PD patients with non-tuberculous mycobacterial infections were investigated at our hospital. Non-tuberculous mycobacteria were detected in 11 patients (exit-site infection, tunnel infection, and peritonitis in 3, 5, and 3 patients, respectively). Mycobacterium fortuitum , Mycobacterium chelonae , and Mycobacterium abscessus were identified in 4, 2, and 2 patients, respectively...
March 2018: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/29531827/-mycobacterium-fortuitum-induced-er-mitochondrial-calcium-dynamics-promotes-calpain-caspase-12-caspase-9-mediated-apoptosis-in-fish-macrophages
#9
Debika Datta, Preeti Khatri, Ambika Singh, Dhira Rani Saha, Gaurav Verma, Rajagopal Raman, Shibnath Mazumder
Mycobacterium fortuitum is a natural fish pathogen. It induces apoptosis in headkidney macrophages (HKM) of catfish, Clarias sp though the mechanism remains largely unknown. We observed M. fortuitum triggers calcium (Ca2+ ) insult in the sub-cellular compartments which elicits pro-apototic ER-stress factor CHOP. Alleviating ER-stress inhibited CHOP and attenuated HKM apoptosis implicating ER-stress in the pathogenesis of M. fortuitum . ER-stress promoted calpain activation and silencing the protease inhibited caspase-12 activation...
December 2018: Cell Death Discovery
https://www.readbyqxmd.com/read/29516862/cutaneous-mycobacteriosis-in-a-captive-amazonian-manatee-trichechus-inunguis
#10
Laura Reisfeld, Cássia Yumi Ikuta, Laura Ippolito, Bruna Silvatti, José Soares Ferreira Neto, José Luiz Catão-Dias, Fernando C W Rosas, José Anselmo Neto, Vera M F da Silva
An adult male Amazonian manatee Trichechus inunguis under human care presented with 3 circular cutaneous lesions on the dorsal aspect of the rostrum and between the nostrils (plenum). Initially these lesions were superficial, hypopigmented, without warmth and non-painful. Microbiological cultures of skin swabs isolated Candida sp. and Pseudomonas aeruginosa, and topical treatment with antiseptic, antifungal, anti-inflammatory and antibiotic medication was instituted. This treatment strategy did not lead to any clinical improvement, and after 6 mo, the lesions progressed to a confluent abscess (5...
March 5, 2018: Diseases of Aquatic Organisms
https://www.readbyqxmd.com/read/29515167/accuracy-of-matrix-assisted-laser-desorption-ionization-time-of-flight-mass-spectrometry-for-identification-of-mycobacteria-a-systematic-review-and-meta-analysis
#11
Yan Cao, Lei Wang, Ping Ma, Wenting Fan, Bing Gu, Shaoqing Ju
Mycobacterium species are a significant cause of morbidity and mortality worldwide. The present study was carried out to systematically evaluate the accuracy of Matrix-assisted laser desorption ionization-time of flight mass spectroscopy (MALDI-TOF MS) for the identification of clinical pathogenic mycobacteria. After a rigid selection process, 19 articles involving 2,593 mycobacteria isolates were included. The pooled result agreed with the reference method identification for 85% of the isolates to genus level, with 71% (95% CI of 69% to 72%) correct to the species level...
March 7, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29497402/phylogenomics-and-comparative-genomic-studies-robustly-support-division-of-the-genus-mycobacterium-into-an-emended-genus-mycobacterium-and-four-novel-genera
#12
Radhey S Gupta, Brian Lo, Jeen Son
The genus Mycobacterium contains 188 species including several major human pathogens as well as numerous other environmental species. We report here comprehensive phylogenomics and comparative genomic analyses on 150 genomes of Mycobacterium species to understand their interrelationships. Phylogenetic trees were constructed for the 150 species based on 1941 core proteins for the genus Mycobacterium , 136 core proteins for the phylum Actinobacteria and 8 other conserved proteins. Additionally, the overall genome similarity amongst the Mycobacterium species was determined based on average amino acid identity of the conserved protein families...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29483162/phda-catalyzes-the-first-step-of-phenazine-1-carboxylic-acid-degradation-in-mycobacterium-fortuitum
#13
Kyle C Costa, Leon S Moskatel, Lucas A Meirelles, Dianne K Newman
Phenazines are a class of bacterially produced redox-active metabolites that are found in natural, industrial, and clinical environments. In Pseudomonas spp., phenazine-1-carboxylic acid (PCA)-the precursor of all phenazine metabolites-facilitates nutrient acquisition, biofilm formation, and competition with other organisms. While the removal of phenazines negatively impacts these activities, little is known about the genes or enzymes responsible for phenazine degradation by other organisms. Here, we report that the first step of PCA degradation by Mycobacterium fortuitum is catalyzed by a <u>ph</u>enazine-<u>d</u>egrading decarboxylase (PhdA)...
May 15, 2018: Journal of Bacteriology
https://www.readbyqxmd.com/read/29481309/tnf-%C3%AE-mediated-er-stress-causes-elimination-of-mycobacterium-fortuitum-reservoirs-by-macrophage-apoptosis
#14
Sung-Man Oh, Yun-Ji Lim, Ji-Ae Choi, Junghwan Lee, Soo-Na Cho, Dam Go, Seon-Hwa Kim, Chang-Hwa Song
Mycobacterium fortuitum (MF), a rapidly growing nontuberculosis mycobacterium, is recognized as an important human pathogen. We investigated whether the endoplasmic reticulum (ER) stress response is associated with the apoptosis of MF-infected macrophages. The expression of ER molecular chaperones was significantly induced by MF infection. We found that MF-induced reactive oxygen species (ROS) generation plays a critical role in the induction of ER stress-mediated apoptosis. Excess TNF-α in the ER led to ER stress-mediated apoptosis during MF infection...
February 26, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29476412/clinical-features-of-infection-caused-by-non-tuberculous-mycobacteria-7-years-experience
#15
Tatjana Adzic-Vukicevic, Aleksandra Barac, Ana Blanka-Protic, Marija Laban-Lazovic, Bojana Lukovic, Vesna Skodric-Trifunovic, Salvatore Rubino
INTRODUCTION: Non-tuberculous mycobacteria (NTM) are ubiquitous organisms associated with various infections. The aim of the study was to determine the most relevant clinical characteristics of NTM during the 7-year period. METHODOLOGY: A retrospective study of NTM infections was conducted between January 2009 and December 2016. The American Thoracic Society/Infectious Disease Society of America criteria were used to define cases of pulmonary or an extrapulmonary site...
February 23, 2018: Infection
https://www.readbyqxmd.com/read/29469752/cutaneous-infection-with-mycobacterium-fortuitum-after-subcutaneous-injection-of-human-chorionic-gonadotropin
#16
Brett C Neill, Nathan C Bahr, Zachary Bryan, Daniel J Aires
Weight loss clinics are common in the United States.  Unfortunately, some offer dubious weight loss methods such as self-administered human chorionic gonadotropic (HCG) injections. HCG products are unregulated, yet, widely available. Infection is among the risks potentially associated with this treatment.  We report a case of skin infection caused by Mycobacterium fortuitum after HCG injection.
August 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29469732/mycobacterium-fortuitum-infection-after-acupuncture-treatment
#17
T Gracia-Cazaña, A Milagro, F Queipo, Y Gilaberte
Actinic keratoses are cutaneous lesions that appear as the result of the proliferation of atypical keratinocytes. These lesions are considered pre-malignant and they can progress to squamous cell carcinoma. Ingenol mebutate has been approved as an effective treatment for AK on the face and trunk. We studied the local skin reactions to this therapy. Data about local skin reactions were collected in a series of 5 patients with photographic documentation, a visual analog scale, and a ranking of satisfaction of the patient...
September 19, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29460734/increasing-prevalence-of-nontuberculous-mycobacteria-in-respiratory-specimens-from-us-affiliated-pacific-island-jurisdictions-1
#18
Chunrong Lin, Chad Russell, Bruce Soll, Dominic Chow, Sapna Bamrah, Richard Brostrom, Wesley Kim, Jerry Scott, Matthew J Bankowski
Nontuberculous mycobacteria (NTM) respiratory infections represent a growing public health problem in many countries. However, there are limited published epidemiologic studies for the Western Pacific region. We reviewed respiratory specimens submitted to Diagnostic Laboratory Services in Hawaii, USA, for culture of Mycobacterium tuberculosis during August 2007-December 2011 to determine the NTM isolation rate. We observed a statistically significant increase in the rate of specimens with NTM isolated in respiratory culture (adjusted rate ratio per year 1...
March 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29458557/evaluation-of-greater-wax-moth-larvae-galleria-mellonella-as-a-novel-in-vivo-model-for-non-tuberculosis-mycobacteria-infections-and-antibiotic-treatments
#19
Frances M Entwistle, Peter J Coote
PURPOSE: To evaluate the suitability of Galleria mellonella larvae as an in vivo model and drug-screening tool for mycobacteria infections. METHODOLOGY: Larvae were infected using a range of inoculum sizes from a variety of rapid-growing mycobacteria, including strains of M. fortuitum, M. marinum and M. aurum. Larval survival, internal bacterial burden and the effects of amikacin, ciprofloxacin, ethambutol, isoniazid and rifampicin treatment on larval survival were measured over 144 h...
April 2018: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29364903/novel-naja-atra-cardiotoxin-1-ctx-1-derived-antimicrobial-peptides-with-broad-spectrum-activity
#20
Andrea Sala, Clotilde Silvia Cabassi, Davide Santospirito, Eugenia Polverini, Sara Flisi, Sandro Cavirani, Simone Taddei
Naja atra subsp. atra cardiotoxin 1 (CTX-1), produced by Chinese cobra snakes, belonging to Elapidae family, is included in the three-finger toxin family and exerts high cytotoxicity and antimicrobial activity too. Using as template mainly the tip and the subsequent β-strand of the first "finger" of this toxin, different sequences of 20 amino acids linear peptides have been designed in order to avoid toxic effects but to maintain or even strengthen the partial antimicrobial activity already seen for the complete toxin...
2018: PloS One
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