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JOURNAL ARTICLE
Maíra Terra Garcia, Paulo Henrique Fonseca do Carmo, Lívia Mara Alves Figueiredo-Godoi, Natália Inês Gonçalves, Patrícia Michelle Nagai de Lima, Lucas de Paula Ramos, Luciane Dias de Oliveira, Alexandre Luiz Souto Borges, Anita Shukla, Juliana Campos Junqueira
Candida albicans can cause various types of oral infections, mainly associated with denture stomatitis. Conventional therapy has been linked to high recurrence, toxicity, and fungal resistance, necessitating the search for new drugs and delivery systems. In this study, caffeic acid phenethyl ester (CAPE) and gellan gum (GG) were studied as an antifungal agent and carrier system, respectively. First, we observed that different GG formulations (0.6 to 1.0% wt/vol) were able to incorporate and release CAPE, reaching a controlled and prolonged release over 180 min at 1...
February 20, 2024: Pharmaceutics
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JOURNAL ARTICLE
Daniela Terra de-Apoena Reche, Nicolle Rakanidis Machado, Beatriz Oliveira Fagundes, Isabella Siuffi Bergamasco, Thamires Rodrigues de Sousa, Lais Alves do Nascimento, Fernando Roberto Machado Cunha, Marilia Garcia de-Oliveira, Fábio da-Ressureição Sgnotto, Carolina Nunes França, Jefferson Russo Victor
Studies about thymic B cells are scarce in the literature, but it was suggested that they can exert modulatory and regulatory functions on the immune system. Thymic B cells can play some role in regulating the most frequent allergic background worldwide, the atopy induced by the mite Dermatophagoides pteronyssinus (Der p). Here, we aimed to evaluate if the polyclonal IgG repertoire produced by Der p-atopic individuals can influence the homing and cytokine profile of human thymic B derived from non-atopic children aged less than seven days...
March 27, 2024: Scientific Reports
#23
JOURNAL ARTICLE
Yuhuan Xie, Krishna M Ella, Terra C Gibbs, Marianne E Yohannan, Stewart M Knoepp, Pravita Balijepalli, G Patrick Meier, Kathryn E Meier
Lysophosphatidic acid (LPA) is a lipid mediator that binds to G-protein-coupled receptors, eliciting a wide variety of responses in mammalian cells. Lyso-phospholipids generated via phospholipase A2 (PLA2 ) can be converted to LPA by a lysophospholipase D (lyso-PLD). Secreted lyso-PLDs have been studied in more detail than membrane-localized lyso-PLDs. This study utilized in vitro enzyme assays with fluorescent substrates to examine LPA generation in membranes from multiple mammalian cell lines (PC12, rat pheochromocytoma; A7r5, rat vascular smooth muscle; Rat-1, rat fibroblast; PC-3, human prostate carcinoma; and SKOV-3 and OVCAR-3, human ovarian carcinoma)...
March 16, 2024: Cells
#24
JOURNAL ARTICLE
Marcelle Brandão Terra, Josiane Lopes, Maria Eduarda Brandão Bueno, Luzia Aparecida Trinca, Suhaila Mahmoud Smaili
BACKGROUND: Fatigue is significant in the context of Parkinson's disease (PD), considering that one-third of patients classify it as the most restricting symptom in their daily life activities (DLAs). The objective was to verify the relationship (association) between fatigue and non-motor and motor symptoms of PD. METHODS: A cross-sectional study which included 100 individuals with PD. Initially, demographic and clinical data (modified Hoehn and Yahr scale-HY, anxiety, and depression) were collected...
March 26, 2024: Neurological Sciences
#25
JOURNAL ARTICLE
Stephanie D Jurburg, María J Álvarez Blanco, Antonis Chatzinotas, Anahita Kazem, Birgitta König-Ries, Doreen Babin, Kornelia Smalla, Victoria Cerecetto, Gabriela Fernandez-Gnecco, Fernanda Covacevich, Emilce Viruel, Yesica Bernaschina, Carolina Leoni, Silvia Garaycochea, Jose A Terra, Pablo Fresia, Eva Lucía Margarita Figuerola, Luis Gabriel Wall, Julieta Mariana Covelli, Ana Carolina Agnello, Esteban Emanuel Nieto, Sabrina Festa, Lina Edith Dominici, Marco Allegrini, María Celina Zabaloy, Marianela Estefanía Morales, Leonardo Erijman, Anahi Coniglio, Fabricio Dario Cassán, Sofia Nievas, Diego M Roldán, Rodolfo Menes, Patricia Vaz Jauri, Carla Silva Marrero, Adriana Montañez Massa, María Adelina Morel Revetria, Ana Fernández-Scavino, Luciana Pereira-Mora, Soledad Martínez, Juan Pablo Frene
Approaches to rapidly collecting global biodiversity data are increasingly important, but biodiversity blind spots persist. We organized a three-day Datathon event to improve the openness of local biodiversity data and facilitate data reuse by local researchers. The first Datathon, organized among microbial ecologists in Uruguay and Argentina assembled the largest microbiome dataset in the region to date and formed collaborative consortia for microbiome data synthesis.
March 21, 2024: Trends in Microbiology
#26
EDITORIAL
Rainer Sabatowski, Johannes Lutz
No abstract text is available yet for this article.
April 2024: Der Schmerz
#27
JOURNAL ARTICLE
Léa Fléchon, Inès Arib, Ankit K Dutta, Lama Hasan Bou Issa, Romanos Sklavenitis-Pistofidis, Remi Tilmont, Chip Stewart, Romain Dubois, Stéphanie Poulain, Marie-Christine Copin, Sahir Javed, Morgane Nudel, Doriane Cavalieri, Guillaume Escure, Nicolas Gower, Paul Chauvet, Nicolas Gazeau, Cynthia Saade, Marietou Binta Thiam, Aïcha Ouelkite-Oumouchal, Silvia Gaggero, Émeline Cailliau, Sarah Faiz, Olivier Carpentier, Nicolas Duployez, Thierry B Idziorek, Laurent Mortier, Martin Figeac, Claude Preudhomme, Bruno Quesnel, Suman Mitra, Franck Morschhauser, Gad Getz, Irene M Ghobrial, Salomon Manier
Mycosis fungoides (MF) is the most prevalent primary cutaneous T-cell lymphoma, with an indolent or aggressive course and poor survival. The pathogenesis of MF remains unclear, and prognostic factors in the early stages are not well-established. Here, we characterized the most recurrent genomic alterations using whole-exome sequencing of 67 samples from 48 patients from Lille University Hospital (France), including 18 sequential samples drawn across stages of the malignancy. Genomic data were analyzed on the Broad Institute's Terra bioinformatics platform...
March 21, 2024: Blood Advances
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JOURNAL ARTICLE
Stephanie Knatz Peck, Terra Towne, Christina Wierenga, Taylor Perry, McKenzie Miller, Jessie Kim, Walter Kaye
BACKGROUND: Eating disorders (ED) are serious mental illnesses affecting young adults (YA). Parent-supported treatment for this age cohort is an important consideration given the unique developmental needs and norms of familial social support, but more research is needed to understand parental perceptions of treatment involvement. METHODS: 33 parent-supports of YA with ED completed self-report assessments at admission and discharge of participation in brief, intensive, young-adult focused eating disorder treatment...
March 21, 2024: European Eating Disorders Review: the Journal of the Eating Disorders Association
#29
JOURNAL ARTICLE
Roy Eerlings, Purvi Gupta, Xiao Yin Lee, Tien Nguyen, Sarah El Kharraz, Florian Handle, Elien Smeets, Lisa Moris, Wout Devlies, Bram Vandewinkel, Irina Thiry, Duy Tien Ta, Anton Gorkovskiy, Karin Voordeckers, Els Henckaerts, Vitor B Pinheiro, Frank Claessens, Kevin J Verstrepen, Arnout Voet, Christine Helsen
Estrogen receptor α is commonly used in synthetic biology to control the activity of genome editing tools. The activating ligands, estrogens, however, interfere with various cellular processes, thereby limiting the applicability of this receptor. Altering its ligand preference to chemicals of choice solves this hurdle but requires adaptation of unspecified ligand-interacting residues. Here, we provide a solution by combining rational protein design with multi-site-directed mutagenesis and directed evolution of stably integrated variants in Saccharomyces cerevisiae...
April 2024: Protein Science
#30
JOURNAL ARTICLE
Priyanka Gupta, Dericks Praise Shukla
The world is currently witnessing the military operations of Russia invading Ukraine, leading to missile bombing and shelling on various parts. Although the economic ill effects are more conspicuous and much talked about, the environmental impacts are grimmer and more devastating but ironically are less in the news. Hence, in this work, we focused on the environmental impact of the Russia-Ukraine war by quantifying the long-term (2001 to 2023) and short-term temperature changes using land surface temperature (LST) and air temperature (AT) as proxies and monitoring changes in air quality, mainly methane (CH4 ), carbon monoxide (CO) and carbon dioxide (CO2 ), between 2021 and 2022...
March 19, 2024: Environmental Science and Pollution Research International
#31
Philippe Maury, Maxime Beneyto
No abstract text is available yet for this article.
March 16, 2024: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
#32
JOURNAL ARTICLE
Glauciene Justino Ferreira da Silva, Richarde Marques da Silva, Reginaldo Moura Brasil Neto, Jorge Flávio Casé B C Silva, Ana Paula Xavier Dantas, Celso Augusto Guimarães Santos
This study analyzed the meteorological and hydrological droughts in a typical basin of the Brazilian semiarid region from 1994 to 2016. In recent decades, this region has faced prolonged and severe droughts, leading to marked reductions in agricultural productivity and significant challenges to food security and water availability. The datasets employed included a digital elevation model, land use and cover data, soil characteristics, climatic data (temperature, wind speed, solar radiation, humidity, and precipitation), runoff data, images from the MODIS/TERRA and AQUA sensors (MOD09A1 and MODY09A1 products), and soil water content...
March 15, 2024: Environmental Monitoring and Assessment
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JOURNAL ARTICLE
Fabio Minamoto, Pedro Araújo, Paula D'Ambrosio, Alberto Dela Vega, Leticia Lauricella, Paulo Pêgo-Fernandes, Ricardo Terra
BACKGROUND: Lung lymphatic drainage occurs mainly through a peribronchial path, but it is hypothesized that visceral pleural invasion could alter this path. This study aims to investigate the association between visceral pleural invasion, node upstaging, and N2 skip metastasis and the impact on survival in a population of patients with non-small cell lung cancer of 3 cm or smaller. METHODS: We retrospectively queried our institutional database of lung cancer resection for all patients with clinical stage IA NSCLC between June 2009 and June 2022...
March 13, 2024: Clinics
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JOURNAL ARTICLE
Andre Zimerman, Stephen D Wiviott, Jeong-Gun Park, Sabina A Murphy, Xinhui Ran, Candace R Bramson, Madelyn Curto, Vesper Ramos, Alexandra Jevne, Julia F Kuder, Subodh Verma, Wojtek Wojakowski, Steven G Terra, Marc S Sabatine, Brian A Bergmark, Nicholas A Marston
AIMS: Remnant cholesterol and very low-density lipoprotein cholesterol (VLDL-C) are increasingly recognized risk factors for atherosclerotic disease with few therapeutic options. Angiopoietin-like 3 (ANGPTL3), a key protein in the metabolism of triglyceride-rich lipoproteins, is a promising target. METHODS AND RESULTS: TRANSLATE-TIMI 70 was a double-blind, placebo-controlled randomized trial testing seven dose regimens of vupanorsen, an antisense oligonucleotide against ANGPTL3, in adults with non-HDL-C ≥ 100 mg/dL and triglycerides 150-500 mg/dL...
March 14, 2024: European Journal of Preventive Cardiology
#35
JOURNAL ARTICLE
Thomas Schwaha, Valentina Cometti, Ahmed J Saadi, Matteo Cecchetto, Stefano Schiaparelli
UNLABELLED: Recent surveys of Antarctic waters in the Terra Nova Bay (Ross Sea) revealed numerous bryozoan species including ctenostome bryozoans. Whereas cheilostome bryozoans are well-studied in these latitudes, ctenostomes remain highly neglected. Large ctenostomes are easily recognized by their lack of calcified skeletons, but this lack also renders them difficult and tedious to identify. As a result, histology and reconstructions of internal soft tissues are required to classify this group of bryozoans...
2024: Organisms, Diversity & Evolution
#36
JOURNAL ARTICLE
Mohamed Baklola, Mohamed Terra, Anhar Taha, Mohammed Elnemr, Mohammad Yaseen, Ahmed Maher, Ali Hussain Buzaid, Rahaf Alenazi, Safa Adil Osman Mohamed, Doaa Abdelhady, Abdel-Hady El-Gilany
BACKGROUND: Mental health literacy (MHL) and help-seeking behaviors are pivotal in managing mental well-being, especially among Egyptian undergraduates. Despite the importance and prevalent psychological distress in this group, limited research has addressed MHL and associated behaviors in Egypt. This study aimed to assess the levels of MHL and help-seeking behavior among Egyptian university students. METHODS: A cross-sectional study was conducted across ten Egyptian universities during the academic year 2022-2023...
March 12, 2024: BMC Psychiatry
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JOURNAL ARTICLE
Ying Wang, Perot Saelao, Ganrea Chanthavixay, Rodrigo A Gallardo, Anna Wolc, Janet E Fulton, Jack M Dekkers, Susan J Lamont, Terra R Kelly, Huaijun Zhou
Heat stress results in significant economic losses to the poultry industry. Genetics plays an important role in chickens adapting to the warm environment. Physiological parameters such as hematochemical parameters change in response to heat stress in chickens. To explore the genetics of heat stress resilience in chickens, a genome-wide association study (GWAS) was conducted using Hy-Line Brown layer chicks subjected to either high ambient temperature or combined high temperature and Newcastle disease virus infection...
February 24, 2024: International Journal of Molecular Sciences
#38
JOURNAL ARTICLE
Stefanni Marmelstein, Igor Pinheiro de Araújo Costa, Adilson Vilarinho Terra, Ricardo Franceli da Silva, Gabriel Pereira de Oliveira Capela, Miguel Ângelo Lellis Moreira, Claudio de Souza Rocha Junior, Carlos Francisco Simões Gomes, Marcos Dos Santos
The production efficiency factor is widely used to measure the zootechnical performance of a batch of broilers. The unit cost of production brings new elements to improve efficiency evaluation and financial sustainability for this activity in agriculture. This research aims to evaluate the production efficiency level of the crop to maximize the return on investment. This study uses Data Envelopment Analysis (DEA) with the computational processing of the SIAD software (Integrated Decision Support System). The variables selected were poultry housing, age at slaughter, feed consumed, mortality, and unit cost...
February 26, 2024: Animals: An Open Access Journal From MDPI
#39
JOURNAL ARTICLE
Meng Xu, Dulmi Senanayaka, Rongwei Zhao, Tafadzwa Chigumira, Astha Tripathi, Jason Tones, Rachel M Lackner, Anne R Wondisford, Laurel N Moneysmith, Alexander Hirschi, Sara Craig, Sahar Alishiri, Roderick J O'Sullivan, David M Chenoweth, Nicholas J Reiter, Huaiying Zhang
The telomere repeat-containing RNA (TERRA) forms R-loops to promote homology-directed DNA synthesis in the alternative lengthening of telomere (ALT) pathway. Here we report that TERRA contributes to ALT via interacting with the lysine-specific demethylase 1A (LSD1 or KDM1A). We show that LSD1 localizes to ALT telomeres in a TERRA dependent manner and LSD1 function in ALT is largely independent of its demethylase activity. Instead, LSD1 promotes TERRA recruitment to ALT telomeres via RNA binding. In addition, LSD1 and TERRA undergo phase separation, driven by interactions between the RNA binding properties of LSD1 and the G-quadruplex structure of TERRA...
March 9, 2024: Nature Communications
#40
JOURNAL ARTICLE
Kalani Gates, Summer Chahin, Amy Damashek, Cheryl Dickson, Grace Lubwama, Debra Lenz, Terra Bautista, Catherine Kothari
OBJECTIVES: Sleep-related infant deaths are a common and preventable cause of infant mortality in the United States. Moreover, infants of color are at a greater risk of sleep-related deaths than are White infants. The American Academy of Pediatrics (AAP) published safe sleep guidelines to minimize the number of sleep-related infant deaths; however, many families face barriers to following these guidelines. Research on the role of psychosocial risk factors (i.e., depression, stress, domestic violence, substance use) in mothers' engagement in safe sleep practices is limited...
March 9, 2024: Maternal and Child Health Journal
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