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Rosangela Am Wailemann, Letícia F Terra, Talita C de Oliveira, Ancély F Dos Santos, Vinícius M Gomes, Leticia Labriola
The success of islet transplantation has improved lately. Unfortunately, it is still compromised by cell loss. We have shown that prolactin (PRL) inhibits beta-cell apoptosis and up-regulates the antiapoptotic Heat Shock Protein B1 (HSPB1) in human islets. Since its function in pancreatic islets has not been studied, we explored the role of HSPB1 in PRL-induced beta-cell survival. The significant PRL-induced cytoprotection in control cells was abrogated in HSPB1 silenced cells, overexpression of HSPB1 recovered survival...
May 21, 2018: Molecular and Cellular Endocrinology
Francisca Alexandra Gavilanes-Oleas, Jose Leonidas Alves, Caio Julio Cesar Fernandes, Luis Felipe Lopes Prada, William Salibe Filho, Mario Terra Filho, Luciana Morinaga, Susana Hoette, Carlos Jardim, Rogerio Souza
OBJECTIVES: Chronic thromboembolic pulmonary hypertension is one of the most prevalent forms of pulmonary hypertension and is a major complication of acute pulmonary embolism. One mainstay of chronic thromboembolic pulmonary hypertension treatment is lifelong anticoagulation. The recent advent of direct oral anticoagulants for acute pulmonary embolism treatment has provided a viable and effective alternative for treating this condition. However, little is known about the efficacy of this new class of drugs for treating chronic thromboembolic pulmonary hypertension...
May 17, 2018: Clinics
Vikas Kumar Dawra, David L Cutler, Susan Zhou, Rajesh Krishna, Haihong Shi, Yali Liang, Christine Alvey, Anne Hickman, Didier Saur, Steven G Terra, Vaishali Sahasrabudhe
Ertugliflozin, a sodium-glucose cotransporter 2 inhibitor for the treatment of adults with type 2 diabetes mellitus, is expected to be coadministered with sitagliptin, metformin, glimepiride, and/or simvastatin. Four separate open-label, randomized, single-dose, crossover studies were conducted in healthy adults to assess the potential pharmacokinetic interactions between ertugliflozin 15 mg and sitagliptin 100 mg (n = 12), metformin 1000 mg (n = 18), glimepiride 1 mg (n = 18), or simvastatin 40 mg (n = 18)...
May 22, 2018: Clinical Pharmacology in Drug Development
Bin Xu, Bor-Yann Chen, Kuan-Chieh Huang, Qing-Jiang Sun, John Chi-Wei Lan
This first-attempt study tended to decipher synergistic interactions of model redox mediators (RMs) to echinenone production for electrochemically-steered fermentation (ESF). The findings indicated that supplement of RMs could significantly stimulate the production performance of fermentation (e.g., 36% for 4-aminophenol) which was parallel with stimulation of bioelectricity generation in microbial fuel cells (MFCs) as prior studies mentioned. Although redox mediators could usually enhance electron transport extracellular compartment, the mechanisms of bioelectricity generation in MFCs and echinenone production in ESF were very likely functioned in the extracellular and the intracellular compartment, respectively...
May 18, 2018: Journal of Bioscience and Bioengineering
David Ortiz, Oscar F Francke, Jason E Bond
Tarantula spider systematics has long been considered problematic. Species diagnosis and phylogenetic hypotheses have historically relied on morphological features, which are known to be relatively conserved and/or highly homoplastic across the family. Morphology-based attempts to clarify the phylogeny of the highly diverse New World Theraphosinae, have only been moderately successful, and the time-frame of tarantulas' evolution is nearly terra incognita. Here we present a molecular phylogenetic analysis of the Theraphosinae genus Bonnetina and related lineages, employing one mitochondrial (COI) and five nuclear (ITS1, EF1G, MID1IP1, MRPL44, and I3568) loci...
May 17, 2018: Molecular Phylogenetics and Evolution
C Truzzi, S Illuminati, M Antonucci, G Scarponi, A Annibaldi
In the Ross Sea region (average temperature of -1.87 °C), shelf water warming up to +0.8-+1.4 °C is predicted by 2200, so there is an urgent need to understand how organisms can respond to rising temperatures. In this study, we analyzed the effect of a heat shock on the fatty acid (FAs) composition of muscle of the Antarctic teleost Trematomus bernacchii, caught in Terra Nova Bay (Ross Sea), and held in fish tanks at 0, +1 or +2 °C, for 1, 5 and 10 days. In general, heat shock produced, beyond a reduction in total lipid content correlated to the temperature, an increase in the percentage of saturated FAs, and a decrease in mono-unsaturated FAs; however, the level of poly-unsaturated FAs did not seem to directly correlate with temperature...
April 3, 2018: Marine Environmental Research
Christopher J Jarchow, Kamel Didan, Armando Barreto-Muñoz, Pamela L Nagler, Edward P Glenn
The Enhanced Vegetation Index (EVI) is a key Earth science parameter used to assess vegetation, originally developed and calibrated for the Moderate Resolution Imaging Spectroradiometer (MODIS) aboard the Terra and Aqua satellites. With the impending decommissioning of the MODIS sensors by the year 2020/2022, alternative platforms will need to be used to estimate EVI. We compared Landsat 5 (2000⁻2011), 8 (2013⁻2016) and the Visible Infrared Imaging Radiometer Suite (VIIRS; 2013⁻2016) to MODIS EVI (2000⁻2016) over a 420,083-ha area of the arid lower Colorado River Delta in Mexico...
May 13, 2018: Sensors
Mrinal M Patnaik, Ana A Pierola, Rangit Vallapureddy, Fevzi F Yalniz, Tapan M Kadia, Elias J Jabbour, Terra Lasho, Curtis A Hanson, Rhett P Ketterling, Hagop M Kantarjian, Ayalew Tefferi, Guillermo Garcia-Manero
No abstract text is available yet for this article.
April 25, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
Victor Alexandre Hardt Ferreira Dos Santos, Marciel José Ferreira, João Victor Figueiredo Cardoso Rodrigues, Maquelle Neves Garcia, João Vitor Barbosa Ceron, Bruce Walker Nelson, Scott Reid Saleska
Sustained drought and concomitant high temperature may reduce photosynthesis and cause tree mortality. Possible causes of reduced photosynthesis include stomatal closure and biochemical inhibition, but their relative roles are unknown in Amazon trees during strong drought events. We assessed the effects of the recent (2015) strong El Niño drought on leaf-level photosynthesis of Central Amazon trees via these two mechanisms. Through four seasons of 2015, we measured leaf gas exchange, chlorophyll a fluorescence parameters, chlorophyll concentration and nutrient content in leaves of 57 upper canopy and understory trees of a lowland terra firme forest on well-drained infertile oxisol...
May 3, 2018: Global Change Biology
Mei-Fang Jin, Xiao-Tian Quan, Muhammad Zubair Siddiqi, Qing-Zhen Liu, Hong-Shan Yu, Wan-Taek Im
A Gram-positive, strictly aerobic, nonmotile, yellowish, coccus-rod-shaped bacterium (designated Gsoil 653T ) isolated from ginseng cultivating soil was characterized using a polyphasic approach to clarify its taxonomic position. The strain Gsoil 653T exhibited optimal growth at pH 7.0 on R2A agar medium at 30°C. Phylogenetic analysis based on 16S rRNA gene sequence similarities, indicated that Gsoil 653T belongs to the genus Terrabacter of the family Humibacillus, and was closely related to Terrabacter tumescens DSM 20308T (98...
May 2018: Journal of Microbiology / the Microbiological Society of Korea
Benjamin D Freemyer, Michael R Migden, Sirunya Silapunt
Terra firma-forme dermatosis (TFFD) is a benign and likely underdiagnosed disorder with relatively few reports in the literature. A 46-year-old woman presented to our clinic with a 3-year history of linear TFFD extending from the upper sacrum to the midline upper back. It initially was thought to be acanthosis nigricans or lichen simplex chronicus, and a topical steroid cream was applied without success. The lesion ultimately was removed by rubbing with isopropyl alcohol, which confirmed a diagnosis of TFFD...
March 2018: Cutis; Cutaneous Medicine for the Practitioner
Sebastian Losada, Pierre Terras
No abstract text is available yet for this article.
May 2018: Nature
Mrinal M Patnaik, Rangit Vallapureddy, Terra L Lasho, Katherine P Hoversten, Christy M Finke, Rhett P Ketterling, Curtis A Hanson, Naseema Gangat, Ayalew Tefferi, Animesh Pardanani
No abstract text is available yet for this article.
April 2, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
Xiaolei Wang, Zhong-Hua Chen, Chongyi Yang, Xuelei Zhang, Gulei Jin, Guang Chen, Yuanyuan Wang, Paul Holford, Eviatar Nevo, Guoping Zhang, Fei Dai
Ecological divergence at a microsite suggests adaptive evolution, and this study examined two abutting wild barley populations, each 100 m across, differentially adapted to drought tolerance on two contrasting soil types, Terra Rossa and basalt at the Tabigha Evolution Slope, Israel. We resequenced the genomes of seven and six wild barley genotypes inhabiting the Terra Rossa and basalt soils, respectively, and identified a total of 69,192,653 single-nucleotide variants (SNVs) and insertions/deletions in comparison with a reference barley genome...
April 30, 2018: Proceedings of the National Academy of Sciences of the United States of America
Ayalew Tefferi, Paola Guglielmelli, Terra L Lasho, Naseema Gangat, Rhett P Ketterling, Animesh Pardanani, Alessandro M Vannucchi
No abstract text is available yet for this article.
April 30, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
I Neri, F Savoia, V Tengattini, A Sechi, P Rucci, A Patrizi
Terra firma-forme dermatosis (TFFD) is an acquired benign disorder that is characterized by brown-gray patches or plaques, presenting as dirt-like pigmented areas (1, 2). The diagnosis is usually confirmed by the clearing with isopropyl or 70% ethyl alcohol swab, that is also the gold standard of treatment. Dermoscopy of TFFD may show large polygonal plate-like brown scales arranged together giving a mosaic or cobblestone pattern (3) This article is protected by copyright. All rights reserved.
April 28, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
Melissa S Deist, Rodrigo A Gallardo, David A Bunn, Terra R Kelly, Jack C M Dekkers, Huaijun Zhou, Susan J Lamont
Behind each eye of the chicken resides a unique lymph tissue, the Harderian gland, for which RNA sequencing (RNA-seq) analysis is novel. We characterized the response of this tissue to Newcastle disease virus (NDV) in two inbred lines with different susceptibility to NDV across three time points. Three-week-old relatively resistant (Fayoumi) and relatively susceptible (Leghorn) birds were inoculated with a high-titered (107 EID50 ) La Sota strain of NDV via an oculonasal route. At 2, 6, and 10 days post infection (dpi) Harderian glands were collected and analyzed via RNA-seq...
April 26, 2018: Scientific Reports
Toshihiro Ito, Fumito Maruyama, Kotaro Sawai, Keiko Nozaki, Keiko Otsu, Kenji Ohya
Mycobacterium virginiense , a newly described species of the Mycobacterium terrae complex, is a cause of tenosynovitis and osteomyelitis in the United States. Here, we report the 4,849,424-bp draft genome sequence of M. virginiense strain GF75, isolated from a mud sample taken from a Japanese swine farm.
April 26, 2018: Genome Announcements
Stefan Schwab, Leonardo Araujo Terra, José Ivo Baldani
Nitrospirillum amazonense is a nitrogen-fixing bacterium that shows potential to promote plant growth when inoculated into sugarcane and rice plants. This microorganism has been the subject of biochemical and genetic characterization to elucidate important functions related to host plant interaction and growth promotion, including the determination of draft genome sequences of two strains, Y2 and CBAmC, the second of which is the aim of the present study. CBAmC has been isolated from sugarcane (Saccharum spp...
April 25, 2018: Molecular Genetics and Genomics: MGG
Barbara Amaral, Adán Cabello, Marcelo Terra Cunha, Leandro Aolita
Contextuality is a fundamental feature of quantum theory necessary for certain models of quantum computation and communication. Serious steps have therefore been taken towards a formal framework for contextuality as an operational resource. However, the main ingredient of a resource theory-a concrete, explicit form of free operations of contextuality-was still missing. Here we provide such a component by introducing noncontextual wirings: a class of contextuality-free operations with a clear operational interpretation and a friendly parametrization...
March 30, 2018: Physical Review Letters
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