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https://www.readbyqxmd.com/read/28719081/drought-induced-mortality-patterns-and-rapid-biomass-recovery-in-a-terra-firme-forest-in-the-colombian-amazon
#1
Daniel Zuleta, Alvaro Duque, Dairon Cardenas, Helene C Muller-Landau, Stuart Davies
Extreme climatic events affecting the Amazon region are expected to become more frequent under ongoing climate change. In this study, we assessed the responses to the 2010 drought of over 14,000 trees ≥ 10 cm dbh in a 25 ha lowland forest plot in the Colombian Amazon and how these responses varied among topographically defined habitats, with tree size, and with species wood density. Tree mortality was significantly higher during the 2010-2013 period immediately after the drought than in 2007-2010. The post-drought increase in mortality was stronger for trees located in valleys (+243%) than for those located on slopes (+67%) and ridges (+57%)...
July 18, 2017: Ecology
https://www.readbyqxmd.com/read/28713153/non-coding-rna-a-protective-role-for-terra-at-telomeres
#2
Linda Koch
No abstract text is available yet for this article.
July 17, 2017: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/28712464/ocrelizumab-edaravone-and-valbenazine
#3
Daniel A Hussar, Terra L Hussar
No abstract text is available yet for this article.
July 2017: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/28710102/the-telomeric-noncoding-rna-terra-regulates-telomere-stability
#4
(no author information available yet)
TERRA activates the DNA damage response at short telomeres to prevent premature senescence.
July 14, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28703316/the-effect-of-renal-impairment-on-the-pharmacokinetics-and-pharmacodynamics-of-ertugliflozin-in-subjects-with-type-2-diabetes-mellitus
#5
V Sahasrabudhe, S G Terra, A Hickman, D Saur, H Shi, M O'Gorman, Z Zhou, D L Cutler
Ertugliflozin is a highly selective and potent inhibitor of the sodium-glucose cotransporter 2 in development for the treatment of type 2 diabetes mellitus. The glycemic efficacy of sodium-glucose cotransporter 2 inhibitors such as ertugliflozin depends on glucose filtration through the kidney. This phase 1, open-label study evaluated the effect of renal impairment on the pharmacokinetics, pharmacodynamics, and tolerability of ertugliflozin (15 mg) in type 2 diabetes mellitus and healthy subjects with normal renal function (estimated glomerular filtration rate not normalized for body surface area ≥90 mL/min) and type 2 diabetes mellitus subjects with mild (60-89 mL/min), moderate (30-59 mL/min), or severe (<30 mL/min) renal impairment (n = 36)...
July 13, 2017: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28702963/duncan%C3%A2-s-dermatosis-from-the-%C3%A2-terra-firma-forme%C3%A2-to-a-possible-syndromic-condition-the-story-of-a-dirty-disease
#6
E Unal, J Lotti, M Fioranelli, M G Roccia, T Lotti, C Guarneri, N Parlak
Since its first description by Duncan, Tschen and Knox in 1987 in the former Archives of Dermatology (1), “Terra firma-forme dermatosis” has been variously described in medical literature, representing a strange, probably underestimated, cutaneous disease. During the last 40 years, the condition has been recorded as an undesirable as well as unexplained event, occurring mainly in childhood, characterized by a brownish-black appearance of the whole skin, resembling dirt. Recently, authors described several cases of atypical patterns of the disease, sometimes with impressing topographic clinical pictures, evocative for syndromic phenotypes...
July 13, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28700693/risk-factors-for-delayed-antiretroviral-therapy-initiation-among-hiv-seropositive-patients
#7
Terra V Fatukasi, Stephen R Cole, Richard D Moore, William C Mathews, Jessie K Edwards, Joseph J Eron
Prompt initiation of combination antiretroviral therapy (ART) is important to reduce comorbidity and mortality among people living with HIV, especially for those with a low CD4 cell count. However there is evidence that not everyone receives prompt initiation of ART after enrolling into HIV care. The current study investigated factors associated with failure to initiate ART within two years of entering into care among those with a CD4 count at or below 350 cells/mm3. The sample included 4,907 ART-naive patients with a CD4 count at or below 350 cells/mm3 enrolled between January 1, 2003 and December 31, 2012 at any of eight clinical sites in the Center for AIDS Research Network of Integrated Clinical Systems (CNICS)...
2017: PloS One
https://www.readbyqxmd.com/read/28700491/long-term-follow-up-of-patients-with-intestinal-neuronal-dysplasia-type-b-protocol-for-an-observational-ambispective-and-comparative-study
#8
Pedro Luiz Toledo de Arruda Lourenção, Erika Veruska Paiva Ortolan, Laura Luiza Minelli Rosa, Marcos Curcio Angelini, Simone Antunes Terra, Maria Aparecida Marchesan Rodrigues
Intestinal neuronal dysplasia type B (IND-B) is a pathological entity of the group of gastrointestinal neuromuscular diseases characterized by complex alterations in the enteric nervous system. Patients typically present with intestinal constipation, sometimes complicated by episodes of intestinal obstruction. The 2 therapeutic modalities include conservative clinical treatment and surgical treatment. Nevertheless, the results of the different therapeutic modalities are conflicting, and follow-up studies are scarce and include only a limited number of patients...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28700009/comparative-study-of-pain-in-women-submitted-to-conventional-laparoscopic-cholecystectomy-versus-single-port-laparoscopic-cholecystectomy
#9
Júverson Alves Terra, Guilherme Azevedo Terra, Marisa de Carvalho Borges, Tharsus Dias Takeuti, Luciana Garcia Pereira Castro, Simone Souza Lima, Luciane Fernanda Rodrigues Martinho Fernandes, Alex Augusto da Silva, Eduardo Crema
Purpose: To evaluate postoperative pain in patients submitted to conventional laparoscopic cholecystectomy with four ports versus single-port laparoscopic cholecystectomy with only one port. Methods: Twenty-one patients were included in the conventional laparoscopic cholecystectomy group and 19 other patients in the single-port laparoscopic cholecystectomy group. A VAS was used for the assessment of postoperative pain at three time points. Differences were considered statistically significant when p<0...
June 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28699867/sporolactobacillus-shoreicorticis-sp-nov-a-lactic-acid-producing-bacterium-isolated-from-tree-bark
#10
Vasana Tolieng, Budsabathip Prasirtsak, Mika Miyashita, Chiyo Shibata, Naoto Tanaka, Nuttha Thongchul, Somboon Tanasupawat
A Gram-stain-positive, lactic acid-producing bacterium designed strain MK21-7T, was isolated from tree bark collected from the north east of Thailand. This strain was a facultatively anaerobic spore-forming rod that was catalase-negative. It contained meso-diaminopimelic acid in the cell wall peptidoglycan and had seven isoprene units (MK-7) as the predominant menaquinone. Major fatty acids of MK21-7T were anteiso-C17 : 0, iso-C16 : 0, anteiso-C15 : 0 and C18 : 1ω9c. Polar lipids were phosphatidglycerol, diphosphatidylglycerol, an unknown phospholipid, three unknown glycolipids and an unknown lipid...
July 12, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28693664/parafilimonas-rhizosphaerae-sp-nov-isolated-from-the-rhizosphere-of-tomato-plant-solanum-lycopersicum-l
#11
Hayoung Cho, Jae-Hyung Ahn, Hang-Yeon Weon, Jae-Ho Joa, Seung-Beom Hong, Soon-Ja Seok, Jeong-Seon Kim, Soon-Wo Kwon, Soo-Jin Kim
A bacterial strain, designated T16E-198T, was isolated from the rhizosphere of tomato plant collected from a farm on Buyeo-gun, Chungcheongnam-do, South Korea. The strain was aerobic, Gram-stain-negative, rod-shaped, non-flagellated and yellow-pigmented. Strain T16E-198T was mesophilic, catalase- and oxidase-positive and with flexirubin-type pigments. A phylogenetic tree based on 16S rRNA gene sequences showed that strain T16E-198T formed a lineage with Parafilimonas terrae 5GHs7-2T, sharing highest sequence similarity of 98...
July 10, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28693524/national-consensus-on-communication-in-prehospital-trauma-care-the-denim-study
#12
Annelieke Maria Karien Harmsen, Leo Maria George Geeraedts, Georgios Fredericus Giannakopoulos, Maartje Terra, Herman M T Christiaans, Lidwine Brigitta Mokkink, Frank Willem Bloemers
BACKGROUND: In the Netherlands prehospital trauma care is provided by emergency medical services (EMS) nurses. This care is extended by Physician staffed Helicopter Emergency Medical Services (P-HEMS) for the more severely injured patient. Prehospital communication is a factor of influence on the identification of these patients and the dispatch of P-HEMS. Though prehospital communication it is often perceived to be incomplete and unstructured. To elucidated factors of influence on prehospital triage and the identification of the severely injured patient a Delphi study was performed...
July 11, 2017: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/28692038/par-terra-directs-homologous-sex-chromosome-pairing
#13
Hsueh-Ping Chu, John E Froberg, Barry Kesner, Hyun Jung Oh, Fei Ji, Ruslan Sadreyev, Stefan F Pinter, Jeannie T Lee
In mammals, homologous chromosomes rarely pair outside meiosis. One exception is the X chromosome, which transiently pairs during X-chromosome inactivation (XCI). How two chromosomes find each other in 3D space is not known. Here, we reveal a required interaction between the X-inactivation center (Xic) and the telomere in mouse embryonic stem (ES) cells. The subtelomeric, pseudoautosomal regions (PARs) of the two sex chromosomes (X and Y) also undergo pairing in both female and male cells. PARs transcribe a class of telomeric RNA, dubbed PAR-TERRA, which accounts for a vast majority of all TERRA transcripts...
July 10, 2017: Nature Structural & Molecular Biology
https://www.readbyqxmd.com/read/28689550/historical-perspective-of-the-wic-program-and-its-breastfeeding-promotion-and-support-efforts
#14
EDITORIAL
Anne Bartholomew, Pascasie Adedze, Valery Soto, Cheryl Funanich, Terra Newman, Patricia MacNeil
No abstract text is available yet for this article.
July 2017: Journal of Nutrition Education and Behavior
https://www.readbyqxmd.com/read/28677478/detection-and-characterization-of-xanthomonas-vasicola-pv-vasculorum-cobb-1894-comb-nov-causing-bacterial-leaf-streak-of-corn-in-the-united-states
#15
Jillian Lang, Elysa DuCharme, Jorge Ibarra Caballero, Emily Luna, Terra Hartman, Mary Ortiz-Castro, Kevin Korus, John Rascoe, Tamra A Jackson, Kirk Broders, Jan Leach
Bacterial leaf streak of corn (Zea mays) recently reached epidemic levels in three corn-growing states, and has been detected in another six states in the central United States. Xanthomonas vasicola was identified as the causal agent of this disease. A multi-locus sequence alignment (MLSA) of six housekeeping genes and comparison of average nucleotide identity (ANI) from draft genome sequence were used to confirm phylogenetic relationships and classification of this bacterium relative to other Xanthomonas vasicola strains...
July 5, 2017: Phytopathology
https://www.readbyqxmd.com/read/28676004/evaluation-of-1-3-benzoxathiol-2-one-derivatives-as-potential-antifungal-agents
#16
Luciana Terra, Eliza de L Chazin, Paola de S Sanches, Max Saito, Marcus V N de Souza, Claudia R B Gomes, James L Wardell, Solange M S V Wardell, Plínio C Sathler, Gabriela C C Silva, Viviane O Lione, Marcos Kalil, Ana Joffily, Helena C Castro, Thatyana R A Vasconcelos
BACKGROUND: Over the last few years, fungal infections have emerged as a worrisome global public health problem. Candidiasis is a disease caused by Candida species and has been a problem worldwide mainly for immunosuppressed patients. Lately, the resistant strains and side effects have been reported as important issues for treating Candidiasis, which have to be solved by identifying new drugs. OBJECTIVE: The goal of this work was to synthesize a series of 1,3-benzoxathiol-2-one derivatives, XY-benzo[d][1,3]oxathiol-2-ones, and evaluate their antifungal activity against five Candida species...
July 3, 2017: Medicinal Chemistry
https://www.readbyqxmd.com/read/28668393/skin-changes-in-streptozotocin-induced-diabetic-rats
#17
Thiago Antônio Moretti Andrade, Daniela Santos Masson-Meyers, Guilherme Ferreira Caetano, Vânia Aparecida Terra, Paula Payão Ovidio, Alceu Afonso Jordão-Júnior, Marco Andrey Cipriani Frade
Diabetes can cause serious health complications, which can affect every organ of the body, including the skin. The molecular etiology has not yet been clarified for all diabetic skin conditions. Thus, this study aimed to investigate the changes of diabetes in skin compared to non-diabetic skin in rats. Fifteen days after establishing the diabetic status, skin samples from the dorsum-cervical region were harvested for subsequent analysis of alterations caused by diabetes. Our results demonstrate that diabetes stimulated higher inflammation and oxidative stress in skin, but antioxidant defense levels were lower compared to the non-diabetic group (p < 0...
June 28, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28666128/terra-rna-antagonizes-atrx-and-protects-telomeres
#18
Hsueh-Ping Chu, Catherine Cifuentes-Rojas, Barry Kesner, Eric Aeby, Hun-Goo Lee, Chunyao Wei, Hyun Jung Oh, Myriam Boukhali, Wilhelm Haas, Jeannie T Lee
Through an integration of genomic and proteomic approaches to advance understanding of long noncoding RNAs, we investigate the function of the telomeric transcript, TERRA. By identifying thousands of TERRA target sites in the mouse genome, we demonstrate that TERRA can bind both in cis to telomeres and in trans to genic targets. We then define a large network of interacting proteins, including epigenetic factors, telomeric proteins, and the RNA helicase, ATRX. TERRA and ATRX share hundreds of target genes and are functionally antagonistic at these loci: whereas TERRA activates, ATRX represses gene expression...
June 29, 2017: Cell
https://www.readbyqxmd.com/read/28666127/approaching-terra-firma-genomic-functions-of-telomeric-noncoding-rna
#19
Caitlin M Roake, Steven E Artandi
Functions of the telomeric repeat-containing RNA (TERRA), the long noncoding RNA (lncRNA) transcribed from telomeres, have eluded researchers. In this issue of Cell, Graf el al. and Chu et al. uncover new regulatory roles for TERRA at the telomere and at distant genomic sites.
June 29, 2017: Cell
https://www.readbyqxmd.com/read/28666126/telomere-length-determines-terra-and-r-loop-regulation-through-the-cell-cycle
#20
Marco Graf, Diego Bonetti, Arianna Lockhart, Kamar Serhal, Vanessa Kellner, André Maicher, Pascale Jolivet, Maria Teresa Teixeira, Brian Luke
Maintenance of a minimal telomere length is essential to prevent cellular senescence. When critically short telomeres arise in the absence of telomerase, they can be repaired by homology-directed repair (HDR) to prevent premature senescence onset. It is unclear why specifically the shortest telomeres are targeted for HDR. We demonstrate that the non-coding RNA TERRA accumulates as HDR-promoting RNA-DNA hybrids (R-loops) preferentially at very short telomeres. The increased level of TERRA and R-loops, exclusively at short telomeres, is due to a local defect in RNA degradation by the Rat1 and RNase H2 nucleases, respectively...
June 29, 2017: Cell
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