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https://www.readbyqxmd.com/read/29352240/transcriptome-analysis-in-spleen-reveals-differential-regulation-of-response-to-newcastle-disease-virus-in-two-chicken-lines
#1
Jibin Zhang, Michael G Kaiser, Melissa S Deist, Rodrigo A Gallardo, David A Bunn, Terra R Kelly, Jack C M Dekkers, Huaijun Zhou, Susan J Lamont
Enhancing genetic resistance of chickens to Newcastle Disease Virus (NDV) provides a promising way to improve poultry health, and to alleviate poverty and food insecurity in developing countries. In this study, two inbred chicken lines with different responses to NDV, Fayoumi and Leghorn, were challenged with LaSota NDV strain at 21 days of age. Through transcriptome analysis, gene expression in spleen at 2 and 6 days post-inoculation was compared between NDV-infected and control groups, as well as between chicken lines...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29352030/the-daunting-polygenicity-of-mental-illness-making-a-new-map
#2
REVIEW
Steven E Hyman
An epochal opportunity to elucidate the pathogenic mechanisms of psychiatric disorders has emerged from advances in genomic technology, new computational tools and the growth of international consortia committed to data sharing. The resulting large-scale, unbiased genetic studies have begun to yield new biological insights and with them the hope that a half century of stasis in psychiatric therapeutics will come to an end. Yet a sobering picture is coming into view; it reveals daunting genetic and phenotypic complexity portending enormous challenges for neurobiology...
March 19, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/29351158/physical-performance-measures-of-flexibility-hip-strength-lower-limb-power-and-trunk-endurance-in-healthy-navy-cadets-normative-data-and-differences-between-sex-and-limb-dominance
#3
Thiago Jambo Alves Lopes, Milena Simic, Daniel de Souza Alves, Priscila Dos Santos Bunn, Allan Inoue Rodrigues, Bruno de Souza Terra, Maicom da Silva Lima, Fabrício Miranda Ribeiro, Patrick Vilão, Evangelos Pappas
The objectives were to provide normative data on commonly used physical performance tests that may be associated with musculoskeletal injuries in Navy cadets, and assess for sex and limb dominance differences. A large cohort of Navy cadets were assessed for physical performance tests of flexibility (ankle dorsiflexion range of motion and sit and reach), isometric hip strength, lower limb power (single leg hop), and trunk endurance (plank and side plank tests). Besides providing normative data tables, sex and limb dominance differences were assessed by a two-way mixed ANOVA...
January 17, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29346837/a-phase-1-randomized-placebo-and-active-controlled-crossover-study-to-determine-the-effect-of-single-dose-ertugliflozin-on-qtc-interval-in-healthy-volunteers
#4
Vaishali Sahasrabudhe, Didier Saur, Kyle Matschke, Steven G Terra, Anne Hickman, Isabelle Huyghe, Haihong Shi, David L Cutler
Ertugliflozin, a selective sodium-glucose cotransporter-2 inhibitor, is being developed for the treatment of type 2 diabetes mellitus. This randomized, 6-sequence, 3-period crossover study assessed the effect of ertugliflozin (100 mg; supratherapeutic dose) vs placebo and moxifloxacin (400 mg; positive control) on the QT interval corrected for heart rate (QTc) in 42 male or female healthy subjects. Triplicate electrocardiograms were performed predose and serially over 48 hours postdose in each treatment period...
January 18, 2018: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/29342094/telomeric-repeat-containing-rnas-terra-decrease-in-squamous-cell-carcinoma-of-the-head-and-neck-is-associated-with-worsened-clinical-outcome
#5
Valerio Vitelli, Paolo Falvo, Solomon G Nergadze, Marco Santagostino, Lela Khoriauli, Paola Pellanda, Giulia Bertino, Antonio Occhini, Marco Benazzo, Patrizia Morbini, Marco Paulli, Camillo Porta, Elena Giulotto
Telomeres are transcribed into noncoding telomeric repeat-containing RNAs (TERRA), which are essential for telomere maintenance. Deregulation of TERRA transcription impairs telomere metabolism and a role in tumorigenesis has been proposed. Head and neck cancer (HNC) is one of the most frequent cancers worldwide, with head and neck squamous cell carcinoma (HNSCC) being the predominant type. Since HNSCC patients are characterized by altered telomere maintenance, a dysfunction in telomere transcription can be hypothesized...
January 17, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29341824/intestinal-lymph-as-a-readout-of-meal-induced-glp-1-release-in-an-unrestrained-rat-model
#6
Nino Jejelava, Sharon Kaufman, Jean-Philippe Krieger, Marcella Martins Terra, Wolfgang Langhans, Myrtha Arnold
Intestinal lymph supposedly provides a readout for the secretion of intestinal peptides. We here assessed how mesenteric lymph duct (MLD) lymph levels of glucagon-like peptide (GLP-1), insulin, and metabolites (Glucose, triglycerides [TG]) evolve after isocaloric high and low fat diet (HFD, LFD) meals, and how they compare to hepatic portal vein (HPV) plasma levels. Moreover, we examined the effects of intraperitoneally (IP) administered GLP-1 (1 or 10 nmol/kg) on these parameters. At 20 min after the HFD meal onset, GLP-1 levels were higher in MLD lymph than in HPV plasma...
January 17, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29340548/the-relation-among-the-physical-activity-level-during-leisure-time-anthropometry-body-composition-and-physical-fitness-of-women-underwent-of-bariatric-surgery-and-an-equivalent-group-with-no-surgery
#7
Caio Machado de Oliveira Terra, Caroline Ferraz Simões, Anselmo Alexandre Mendes, Ronano Pereira Oliveira, Rafaela Pilegi Dada, Victor Hugo de Souza Mendes, João Carlos Locateli, Nelson Nardo-Junior
BACKGROUND: Bariatric surgery is an alternative to the obesity treatment. AIM: To compare anthropometric variables such as body composition and physical fitness of those who performed Roux-en-Y gastric bypass. METHODS: Were evaluated 108 women. They were subdivided in three groups: those who performed the bariatric surgery by private health insurance (SAS, n=36); by the public health care (SUS, n=36), and an equivalent group which did not perform the surgery (NO, n=36)...
October 2017: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/29337547/a-calix-n-arene-catalysed-three-component-povarov-reaction-microwave-assisted-synthesis-of-julolidines-and-mechanistic-insights
#8
Paula Aline da Silva Abranches, Walysson Ferreira de Paiva, Angelo DE Fatima, Felipe Terra Martins, Sergio Antonio Fernandes
A new one-pot cascade reaction-based application of Povarov reactions (MCPRs) with a p-sulfonic acid calix[4]arene (CX4SO3H) catalyst for the synthesis of a series of 34 julolidines derivatives with substituents at C8 or C9 in good to excel-lent yields is reported. These microwave-assisted reactions proceed efficiently, had short reaction times, were metal-free, were low cost, and used an inexpensive, easily available and nontoxic catalyst. These advantages, along with a simple work-up procedure, make this protocol a very efficient and green alternative to the traditional methods for constructing these types of N-heterocyclic skeletons...
January 16, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29333349/annual-and-spatial-variation-in-composition-and-activity-of-terrestrial-mammals-on-two-replicate-plots-in-lowland-forest-of-eastern-ecuador
#9
John G Blake, Bette A Loiselle
Terrestrial mammals are important components of lowland forests in Amazonia (as seed dispersal agents, herbivores, predators) but there are relatively few detailed studies from areas that have not been affected by human activities (e.g., hunting, logging). Yet, such information is needed to evaluate effects of humans elsewhere. We used camera traps to sample medium to large-sized terrestrial mammals at a site in lowland forests of eastern Ecuador, one of the most biologically rich areas in the world. We deployed cameras on two study plots in terra firme forest at Tiputini Biodiversity Station...
2018: PeerJ
https://www.readbyqxmd.com/read/29331329/terra-firma-forme-dermatosis
#10
Alexander K C Leung, Benjamin Barankin, Joseph M Lam
No abstract text is available yet for this article.
January 10, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29322230/migration-of-paraburkholderia-terrae-bs001-along-old-fungal-hyphae-in-soil-at-various-ph-levels
#11
Pu Yang, Renata Oliveira da Rocha Calixto, Jan Dirk van Elsas
The movement of bacterial cells along with fungal hyphae in soil (the mycosphere) has been reported in several previous studies. However, how local soil conditions affect bacterial migration direction in the mycosphere has not been extensively studied. Here, we investigated the influence of two soil parameters, pH and soil moisture content, on the migration, and survival, of Paraburkholderia terrae BS001 in the mycosphere of Lyophyllum sp. strain Karsten in microcosms containing a loamy sand soil. The data showed that bacterial movement along the hyphal networks took place in both the "forward" and the "backward" directions...
January 10, 2018: Microbial Ecology
https://www.readbyqxmd.com/read/29316649/%C3%A2-cat-3-mots-nanosatellite-mission-for-optical-multispectral-and-gnss-r-earth-observation-concept-and-analysis
#12
Jordi Castellví, Adriano Camps, Jordi Corbera, Ramon Alamús
The ³Cat-3/MOTS (3: Cube, Cat: Catalunya, 3: 3rd CubeSat mission/Missió Observació Terra Satèl·lit) mission is a joint initiative between the Institut Cartogràfic i Geològic de Catalunya (ICGC) and the Universitat Politècnica de Catalunya-BarcelonaTech (UPC) to foster innovative Earth Observation (EO) techniques based on data fusion of Global Navigation Satellite Systems Reflectometry (GNSS-R) and optical payloads. It is based on a 6U CubeSat platform, roughly a 10 cm × 20 cm × 30 cm parallelepiped...
January 6, 2018: Sensors
https://www.readbyqxmd.com/read/29316466/metal-complexation-capacity-of-antarctic-lacustrine-sediments
#13
Giancarla Alberti, Matteo Mussi, Federico Quattrini, Maria Pesavento, Raffaela Biesuz
The purpose of this study is to implement a work that is a part of a project funded by the Italian National Antarctic Research Program (PNRA, Piano Nazionale di Ricerche in Antartide) within the main thematic focus "Chemical Contamination-Global Change". This research was devoted to detect and characterize micro and nano components with strong complexing capability towards metal ions at trace level in sea water, lakes and lacustrine sediments, sampled during the XXII expedition of PNRA. In particular, in the present work, the sorption complexation capacity of an Antarctic lacustrine sediments toward Cu(II) and Pb(II) is described...
December 30, 2017: Chemosphere
https://www.readbyqxmd.com/read/29313282/ertugliflozin-and-sitagliptin-co-initiation-in-patients-with-type-2-diabetes-the-vertis-sita-randomized-study
#14
Sam Miller, Tania Krumins, Haojin Zhou, Susan Huyck, Jeremy Johnson, Gregory Golm, Steven G Terra, James P Mancuso, Samuel S Engel, Brett Lauring
INTRODUCTION: Ertugliflozin is an oral sodium-glucose cotransporter 2 inhibitor that is being developed to treat type 2 diabetes mellitus (T2DM). This study assessed the efficacy and safety of co-initiation of ertugliflozin and sitagliptin compared with placebo in patients with T2DM inadequately controlled on diet and exercise. METHODS: In this phase III, randomized, double-blind, multicenter, placebo-controlled 26-week study (NCT02226003), patients with T2DM and glycated hemoglobin (HbA1c) 8...
January 8, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29311175/features-of-terra-firma-forme-dermatosis
#15
Nurşad Çifci Aslan, Şükran Güler, Kamile Demirci, Emel Isiyel
Terra-firma-forme dermatosis (TFFD) is a little known hyperpigmented skin disease that is more common than expected. We examined retrospectively the medical records of 79 patients: 88.6% were children, the mean age was 10.4 years (SD = 7.5 years), and 64.6% were female. The dermatoses were found on the trunk in 27.8%, extremities in 26.6%, fold zones in 8.9%, and head in 2.5% of the patients. The lesions appeared in more than 1 location in 34.2% of the patients and were symmetrically located 77.2% of the time...
January 2018: Annals of Family Medicine
https://www.readbyqxmd.com/read/29303695/sphingobacterium-terrae-sp-nov-isolated-from-oil-contaminated-soil
#16
Dhiraj Kumar Chaudhary, Jaisoo Kim
A cream-coloured, Gram-stain-negative, non-motile and rod-shaped bacterium, designated strain Brt-FT, was isolated from oil-contaminated soil. Strain Brt-FT was able to grow from 15 to 45 °C, pH 6.5-10.5 and 0-4.5 % (w/v) NaCl concentration. This strain was taxonomically characterized by a polyphasic approach. Based on 16S rRNA gene sequence analysis, strain Brt-FT represented a member of the genus Sphingobacterium and shared highest sequence similarity with Sphingobacterium chuzhouense DH-5T (99.4 %); Sphingobacterium gobiense H7T (95...
January 5, 2018: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/29297845/proteus-columbae-sp-nov-isolated-from-a-pigeon-in-ma-anshan-china
#17
Hang Dai, Yonglu Wang, Yujie Fang, Tao Xiao, Zhenzhou Huang, Biao Kan, Duochun Wang
A Gram-negative, facultatively anaerobic bacillus, strain 08MAS2615T, was isolated from the flesh of a pigeon specimen collected in Ma'anshan, Anhui province, China. Phylogenetic analysis of 16S rRNA gene sequences confirmed that strain 08MAS2615T belonged to the genus Proteus, and formed an independent branch which was clearly separated from the other six known species of Proteus. Strain 08MAS2615T was more closely related to Proteus vulgaris ATCC 29905T and Proteus penneri NCTC 12737T than other Proteus species...
January 3, 2018: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/29295750/ereboglobus-luteus-gen-nov-sp-nov-from-cockroach-guts-and-new-insights-into-the-oxygen-relationship-of-the-genera-opitutus-and-didymococcus-verrucomicrobia-opitutaceae
#18
Dorothee Tegtmeier, Alexandra Belitz, Renate Radek, Thomas Heimerl, Andreas Brune
We isolated a novel member of the phylum Verrucomicrobia from the hindgut of the cockroach Shelfordella lateralis. Strain Ho45 is a yellow-pigmented, motile coccus that represents a new genus-level lineage with less than 93% sequence similarity to the 16S rRNA genes of other species in the family Opitutaceae. Ultrastructural analysis revealed a Gram-negative cell envelope with an outer membrane and a periplasmic space. In its ability to ferment sugars to propionate and acetate as major products, strain Ho45 resembles its closest relative, Opitutus terrae...
December 21, 2017: Systematic and Applied Microbiology
https://www.readbyqxmd.com/read/29290547/the-influence-of-noise-on-the-vocal-dose-in-women
#19
Alessandra Terra Vasconcelos Rabelo, Juliana Nunes Santos, Bárbara Oliveira Souza, Ana Cristina Côrtes Gama, Max de Castro Magalhães
OBJECTIVE: The objective of this study was to evaluate if noise interferes with the vocal dose in women without vocal complaints. STUDY DESIGN: This is an experimental and comparative study. METHODS: Data were collected on 27 women between 22 and 50 years of age without vocal complaints in a university classroom. Speech-language pathology evaluation was performed employing auditory-perceptual analysis and a vocal symptom questionnaire. The acoustics of the classroom were evaluated via both observation of the characteristics of the room and the quantification of background noise and reverberation time...
December 28, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/29286636/topology-of-intermetallic-structures-from-statistics-to-rational-design
#20
Tatiana G Akhmetshina, Vladislav A Blatov, Davide M Proserpio, Alexander P Shevchenko
More than 38 000 substances made only of metal atoms are collected in modern structural databases; we may call them intermetallic compounds. They have important industrial applications, and yet they are terra incognita for most of our undergraduate students. Their structural complexity and synthesis are not easily adaptable to first years laboratories, keeping them away from the standard curricula. They have been described over the years following alternative and complementary views such as coordination polyhedra, atomic layers, and polyatomic clusters...
December 29, 2017: Accounts of Chemical Research
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