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https://www.readbyqxmd.com/read/28079245/gastric-and-jejunal-histopathological-changes-in-patients-undergoing-bariatric-surgery
#1
Rosemary Simões Nomelini Rodrigues, Élia Cláudia de Souza Almeida, Júverson Alves Terra, Lucinda Calheiros Guimarães, Ana Cristina da Rocha Duque, Renata Margarida Etchebehere
BACKGROUND: - Morbid obesity is a multifactorial disease that is increasingly treated by surgery. OBJECTIVE: - To evaluate gastric histopathological changes in obese, and to compare with patients who underwent gastrojejunal bypass and the jejunal mucosa after the surgery. METHODS: - This is an observational study performed at a tertiary public hospital, evaluating endoscopic biopsies from 36 preoperative patients and 35 postoperative. RESULTS: - In the preoperative group, 80...
January 2017: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/28077594/the-n-linking-glycosylation-system-from-actinobacillus-pleuropneumoniae-is-required-for-adhesion-and-has-potential-use-in-glycoengineering
#2
Jon Cuccui, Vanessa S Terra, Janine T Bossé, Andreas Naegeli, Sherif Abouelhadid, Yanwen Li, Chia-Wei Lin, Prerna Vohra, Alexander W Tucker, Andrew N Rycroft, Duncan J Maskell, Markus Aebi, Paul R Langford, Brendan W Wren
Actinobacillus pleuropneumoniae is a mucosal respiratory pathogen causing contagious porcine pleuropneumonia. Pathogenesis studies have demonstrated a major role for the capsule, exotoxins and outer membrane proteins. Actinobacillus pleuropneumoniae can also glycosylate proteins, using a cytoplasmic N-linked glycosylating enzyme designated NGT, but its transcriptional arrangement and role in virulence remains unknown. We investigated the NGT locus and demonstrated that the putative transcriptional unit consists of rimO, ngt and a glycosyltransferase termed agt...
January 2017: Open Biology
https://www.readbyqxmd.com/read/28076350/emergence-of-rare-species-of-nontuberculous-mycobacteria-as-potential-pathogens-in-saudi-arabian-clinical-setting
#3
Bright Varghese, Mushira Enani, Mohammed Shoukri, Sahar AlThawadi, Sameera AlJohani, Sahal Al-Hajoj
BACKGROUND: Clinical relevance of nontuberculous mycobacteria (NTM) is increasing worldwide including in Saudi Arabia. A high species diversity of NTM's has been noticed in a recent study. However, the identification in diagnostic laboratories is mostly limited to common species. The impact of NTM species diversity on clinical outcome is so far neglected in most of the clinical settings. METHODOLOGY/PRINCIPAL FINDINGS: During April 2014 to September 2015, a nationwide collection of suspected NTM clinical isolates with clinical and demographical data were carried out...
January 11, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28073405/rhodanobacter-humi-sp-nov-a-novel-acidtolerant-and-alkalitolerant-gammaproteobacterium-isolated-from-kyonggi-university-forest-soil
#4
Ram Hari Dahal, Jaisoo Kim
A novel acidtolerant and alkalitolerant gammaproteobacterium designated strain RS22T was isolated from Kyonggi University forest soil. Cells were aerobic, Gram-staining-negative, catalase- and oxidase- positive, non-motile, non-spore-forming, rod-shaped, and yellow-pigmented. Flexirubin-type pigments were absent. Strain RS22T assimilates lactic acid, L-proline, and 3-hydroxybenzoic acid; tolerates 4 % of NaCl, ferments glucose, and can grow at pH 11.0. A phylogenetic analysis based on its 16S rRNA gene sequence revealed that strain RS22T formed a lineage within the class Gammaproteobacteria of the phylum Proteobacteria that was distinct from various species of the genus Rhodanobacter, including Rhodanobacter denitrificans 2APBS1T (97...
January 10, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28072419/an-acid-tolerant-ammonia-oxidizing-%C3%AE-proteobacterium-from-soil
#5
Masahito Hayatsu, Kanako Tago, Ikuo Uchiyama, Atsushi Toyoda, Yong Wang, Yumi Shimomura, Takashi Okubo, Futoshi Kurisu, Yuhei Hirono, Kunihiko Nonaka, Hiroko Akiyama, Takehiko Itoh, Hideto Takami
Nitrification, the microbial oxidation of ammonia to nitrate via nitrite, occurs in a wide range of acidic soils. However, the ammonia-oxidizing bacteria (AOB) that have been isolated from soil to date are acid-sensitive. Here we report the isolation and characterization of an acid-adapted AOB from an acidic agricultural soil. The isolated AOB, strain TAO100, is classified within the Gammaproteobacteria based on phylogenetic characteristics. TAO100 can grow in the pH range of 5-7.5 and survive in highly acidic conditions until pH 2 by forming cell aggregates...
January 10, 2017: ISME Journal
https://www.readbyqxmd.com/read/28060494/copper-complexes-as-bioinspired-models-for-lytic-polysaccharide-monooxygenases
#6
Alda Lisa Concia, Maria Rosa Beccia, Maylis Orio, Francine Terra Ferre, Marciela Scarpellini, Frédéric Biaso, Bruno Guigliarelli, Marius Réglier, A Jalila Simaan
We report here two copper complexes as first functional models for lytic polysaccharide monooxygenases, mononuclear copper-containing enzymes involved in recalcitrant polysaccharide breakdown. These complexes feature structural and spectroscopic properties similar to those of the enzyme. In addition, they catalyze oxidative cleavage of the model substrate p-nitrophenyl-β-d-glucopyranoside. More importantly, a particularly stable copper(II) hydroperoxide intermediate is detected in the reaction conditions.
January 6, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28059508/non-classical-size-dependence-of-permeation-defines-bounds-for-passive-adsorption-of-large-drug-molecules
#7
Cameron R Pye, William M Hewitt, Joshua A Schwochert, Terra D Haddad, Chad E Townsend, Lyns Etienne, Yongtong Lao, Chris Limberakis, Akihiro Furukawa, Alan M Mathiowetz, David A Price, Spiros Liras, R Scott Lokey
There is a growing number of intracellular protein-protein interactions (PPI's) with potential therapeutic importance that demand larger ligands than those that neatly fit into most common criteria for "drug-likeness". Macrocyclic peptides pro-vide the large surface area required to inhibit PPIs and, in principle, avoid many of the pitfalls associated with peptides, including low stability and membrane permeability. However, the design of passively cell-permeable molecules in this space remains a great challenge due to the poorly understood roles of molecular size and lipophilicity in determining pas-sive membrane permeability above MW ~500...
January 6, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28058734/high-fat-diet-and-fish-oil-affect-adipocyte-metabolism-in-a-depot-specific-manner
#8
Letícia F Terra, Aline R M Lobba
It is well known that the white adipose tissue (WAT) plays a central role in the control of metabolism; therefore it can be related to several disorders, such as obesity, type-2 diabetes mellitus, and metabolic syndrome, mainly by inflammation and hypertrophy. This article is protected by copyright. All rights reserved.
January 6, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28057748/complete-genome-sequences-of-38-gordonia-sp-bacteriophages
#9
Welkin H Pope, Matthew T Montgomery, J Alfred Bonilla, Randall Dejong, Rebecca A Garlena, Carlos Guerrero Bustamante, Karen K Klyczek, Daniel A Russell, John T Wertz, Deborah Jacobs-Sera, Graham F Hatfull
We report here the genome sequences of 38 newly isolated bacteriophages using Gordonia terrae 3612 (ATCC 25594) and Gordonia neofelifaecis NRRL59395 as bacterial hosts. All of the phages are double-stranded DNA (dsDNA) tail phages with siphoviral morphologies, with genome sizes ranging from 17,118 bp to 93,843 bp and spanning considerable nucleotide sequence diversity.
January 5, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28054667/yersinia-pestis-halotolerance-illuminates-plague-reservoirs
#10
Maliya Alia Malek, Idir Bitam, Anthony Levasseur, Jérôme Terras, Jean Gaudart, Said Azza, Christophe Flaudrops, Catherine Robert, Didier Raoult, Michel Drancourt
The plague agent Yersinia pestis persists for years in the soil. Two millennia after swiping over Europe and North Africa, plague established permanent foci in North Africa but not in neighboring Europe. Mapping human plague foci reported in North Africa for 70 years indicated a significant location at <3 kilometers from the Mediterranean seashore or the edge of salted lakes named chotts. In Algeria, culturing 352 environmental specimens naturally containing 0.5 to 70 g/L NaCl yielded one Y. pestis Orientalis biotype isolate in a 40 g/L NaCl chott soil specimen...
January 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28050547/radial-head-fracture-associated-with-posterior-interosseous-nerve-injury
#11
Bernardo Barcellos Terra, Tannus Jorge Sassine, Guilherme de Freitas Lima, Leandro Marano Rodrigues, David Victoria Hoffmann Padua, Anderson de Nadai
: Fractures of the radial head and radial neck correspond to 1.7-5.4% of all fractures and approximately 30% may present associated injuries. In the literature, there are few reports of radial head fracture with posterior interosseous nerve injury. This study aimed to report a case of radial head fracture associated with posterior interosseous nerve injury. CASE REPORT: A male patient, aged 42 years, sought medical care after falling from a skateboard. The patient related pain and limitation of movement in the right elbow and difficulty to extend the fingers of the right hand...
November 2016: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/28042162/attracting-new-clients-with-the-first-phone-call
#12
Terra Shastri
No abstract text is available yet for this article.
January 2017: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://www.readbyqxmd.com/read/28034593/one-health-proof-of-concept-bringing-a-transdisciplinary-approach-to-surveillance-for-zoonotic-viruses-at-the-human-wild-animal-interface
#13
Terra R Kelly, William B Karesh, Christine Kreuder Johnson, Kirsten V K Gilardi, Simon J Anthony, Tracey Goldstein, Sarah H Olson, Catherine Machalaba, Jonna A K Mazet
As the world continues to react and respond inefficiently to emerging infectious diseases, such as Middle Eastern Respiratory Syndrome and the Ebola and Zika viruses, a growing transdisciplinary community has called for a more proactive and holistic approach to prevention and preparedness - One Health. Such an approach presents important opportunities to reduce the impact of disease emergence events and also to mitigate future emergence through improved cross-sectoral coordination. In an attempt to provide proof of concept of the utility of the One Health approach, the US Agency for International Development's PREDICT project consortium designed and implemented a targeted, risk-based surveillance strategy based not on humans as sentinels of disease but on detecting viruses early, at their source, where intervention strategies can be implemented before there is opportunity for spillover and spread in people or food animals...
December 14, 2016: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28032199/does-dental-trauma-in-the-primary-dentition-increases-the-likelihood-of-trauma-in-the-permanent-dentition-a-longitudinal-study
#14
Marília Leão Goettems, Letícia Coutinho Brancher, Catiara Terra da Costa, Maria Laura Menezes Bonow, Ana Regina Romano
OBJECTIVES: The aim of this longitudinal study was to assess the likelihood of children suffering traumatic dental injuries in the permanent dentition subsequent to traumatic dental injuries in their primary dentition. MATERIALS AND METHODS: A longitudinal study was conducted in Pelotas, Brazil. Children were assessed in 2007, when they were aged 2-5 years, and in 2013, at which time, they were aged 8-11 years. Data collection included interviews with parents and clinical oral examination for dental trauma and occlusion...
December 28, 2016: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28025082/identification-of-g-quadruplex-dna-rna-binders-structure-based-virtual-screening-and-biophysical-characterization
#15
Roberta Rocca, Federica Moraca, Giosuè Costa, Matteo Nadai, Matteo Scalabrin, Carmine Talarico, Simona Distinto, Elias Maccioni, Francesco Ortuso, Anna Artese, Stefano Alcaro, Sara N Richter
BACKGROUND: Recent findings demonstrated that, in mammalian cells, telomere DNA (Tel) is transcribed into telomeric repeat-containing RNA (TERRA), which is involved in fundamental biological processes, thus representing a promising anticancer target. For this reason, the discovery of dual (as well as selective) Tel/TERRA G-quadruplex (G4) binders could represent an innovative strategy to enhance telomerase inhibition. METHODS: Initially, docking simulations of known Tel and TERRA active ligands were performed on the 3D coordinates of bimolecular G4 Tel DNA (Tel2) and TERRA (TERRA2)...
December 23, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28017711/evaluation-of-the-hypothesis-that-choking-alte-may-mimic-abusive-head-trauma
#16
Jennifer B Hansen, Terra Frazier, Mary Moffatt, Timothy Zinkus, James D Anderst
OBJECTIVE: Apparent life-threatening events (ALTEs), often accompanied by choking, have been hypothesized to cause subdural hemorrhages (SDH), retinal hemorrhages, and brain injury. If the choking/ALTE hypothesis were true, children who present with ALTE and SDH would have fewer extracranial injuries suspicious for abuse than those with SDH and no ALTE. We aimed to compare the prevalence of suspicious extracranial injuries in children who have ALTE-associated SDH to those with non-ALTE SDH...
December 22, 2016: Academic Pediatrics
https://www.readbyqxmd.com/read/28012956/systematics-and-biogeography-of-the-automolus-infuscatus-complex-aves-furnariidae-cryptic-diversity-reveals-western-amazonia-as-the-origin-of-a-transcontinental-radiation
#17
Eduardo D Schultz, Curtis W Burney, Robb T Brumfield, Erico M Polo, Joel Cracraft, Camila C Ribas
A revision of the avian Neotropical genus Automolus and the Furnariidae family points to the paraphyly of A. infuscatus and reveals a species complex comprising A. infuscatus, A. ochrolaemus, A. paraensis, A. leucophthalmus, A. lammi and A. subulatus, the latter historically classified in the genus Hyloctistes. Detailed knowledge of the taxonomy, geographic distribution, phylogenetic relationship and divergence times of a taxon allows exploration of its evolutionary history and the testing of different scenarios of diversification...
December 22, 2016: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/28005518/nocardioides-phosphati-sp-nov-an-actinomycete-isolated-from-a-phosphate-mine
#18
Fuhong Xie, Yang Yang, Huan Ma, Shujing Quan, Dandan Yue, Yufei Sun, Fei Feng, Jing Zheng, Dehai Liu
A Gram-staining-positive, non-spore-forming and non-motile strain designated WYH11-7T was isolated from a phosphate mine in Yunnan Province, China. The taxonomic position of strain WYH11-7T was investigated by polyphasic approaches. Phylogenetic analyses based on 16S rRNA gene sequences indicated that strain WYH11-7T is a member of the genus Nocardioides. Strain WYH11-7T was closely related to Nocardioides jensenii DSM 20641T, Nocardioides dubius DSM 19084T, and Marmoricola terrae DSM 27141T, and had a pairwise 16S rRNA gene sequence similarities of 97...
December 22, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28000572/-vismodegib-for-basal-cell-carcinoma-targeted-therapy-in-case-of-locally-advanced-or-metastasised-disease
#19
M G H C Reinders, J B Terra, A K L Reyners, M J Aarts, E R M de Haas, K Mosterd
The development of the hedgehog pathway inhibitor vismodegib provides a new treatment option for metastasised and locally advanced basal cell carcinoma in which surgical excision or radiotherapy is contraindicated. Only a fraction of patients with basal cell carcinoma are eligible for this therapy, but it is effective in the majority of those who do receive vismodegib. However, development of tumour resistance is quite common and adverse events frequently lead to discontinuation of therapy. Intermittent treatment or combination therapy could reduce the occurrence of tumour resistance and diminish toxicity...
2016: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/27996362/the-effects-of-di-2-ethyl-hexyl-phthalate-dehp-on-cellular-lipid-accumulation-in-hepg2-cells-and-its-potential-mechanisms-in-the-molecular-level
#20
Wang Zhang, Xin-Yue Shen, Wen-Wen Zhang, Hao Chen, Wei-Ping Xu, Wei Wei
Diethylhexyl phthalate (DEHP) is suspected to be an inevitable factor related to metabolic disease. Our previous study demonstrated that excess DEHP could exacerbate Non Alcoholic Fatty Liver Disease(NAFLD) in SD rats. Addressing the terra incognita in DEHP-induced metabolic dysfunction, this study used HepG2 cells to investigate the potential mechanisms involved in DEHP-induced toxicity in vitro. The cells were established lipid overload model with oleic acid and BSA, then exposed to different concentrations (5, 10, 25, 50, 100 μmol/l DEHP) of DEHP for further analysis...
December 20, 2016: Toxicology Mechanisms and Methods
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