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https://www.readbyqxmd.com/read/28543953/improved-technical-success-postnatal-outcomes-and-refined-predictors-of-outcome-for-fetal-aortic-valvuloplasty
#1
Kevin G Friedman, Lynn A Sleeper, Lindsay R Freud, Audrey C Marshall, Max E Godfrey, Monika Drogosz, Terra Lafranchi, Carol B Benson, Louise E Wilkins-Haug, Wayne Tworetzky
BACKGROUND: Fetal aortic valvuloplasty (FAV) may prevent progression of mid-gestation aortic stenosis (AS) to hypoplastic left heart syndrome (HLHS). METHODS: We evaluate outcomes in 123 fetuses that underwent FAV between 2000 and 2015. We analyze whether technical success and biventricular (Biv) outcome changed from the early era (2000-08) to a more recent era (2009-15) and identify pre-FAV predictors of Biv outcome. We developed CART models to predict the likelihood of Biv outcome...
May 22, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28539310/terra-firma-forme-dermatosis
#2
Caroline P Allen, Genevieve A Casey, Charlotte Forrest, Halin Leung, Tess McPherson
No abstract text is available yet for this article.
May 24, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28516032/a-case-of-respiratory-infection-possibly-caused-by-mycobacterium-triviale-current-problems-on-diagnostic-and-therapeutic-strategies
#3
Asako Okabayashi, Mizue Hasegawa, Akitoshi Sato, Hideki Katsura, Toshiko Kamata, Eitetsu Koh, Yasuo Sekine
Mycobacterium triviale is a subspecies of the Mycobacterium terrae complex, which rarely causes disease in humans. We encountered a case of respiratory infection, possibly caused by M. triviale, which was successfully treated by levofloxacin and clarithromycin. Although DNA-DNA hybridization identified M. triviale in one of three samples, clinical validations convinced us that it was the pathogen. 16s ribosomal RNA sequencing would have been reliable and ideal to perform in this case, although it is not covered by the insurance system in Japan...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28513782/soil-vegetation-relationships-and-community-structure-in-a-terra-firme-white-sand-vegetation-gradient-in-viru%C3%A3-national-park-northern-amazon-brazil
#4
Bruno A F DE Mendonça, Elpídio I Fernandes, Carlos E G R Schaefer, Júlia G F DE Mendonça, Bruno N F Vasconcelos
Viruá National Park encompasses a vast and complex system of hydromorphic sandy soils covered largely by the white sand vegetation ("Campinarana") ecosystem. The purpose of this study was to investigate a vegetation gradient of "terra-firme"-white sand vegetation at the Viruá National Park. Nine plots representing three physiognomic units were installed for floristic and phytosociological surveys as well as to collect composite soil samples. The data were subjected to assessments of floristic diversity and similarity, phytosociological parameters and to statistical analyses, focused on principal components (PC) and canonical correspondence analysis (CCA)...
May 15, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28513547/epigenetic-regulation-of-telomere-maintenance-for-therapeutic-interventions-in-gliomas
#5
REVIEW
Elisabeth Naderlinger, Klaus Holzmann
High-grade astrocytoma of WHO grade 4 termed glioblastoma multiforme (GBM) is a common human brain tumor with poor patient outcome. Astrocytoma demonstrates two known telomere maintenance mechanisms (TMMs) based on telomerase activity (TA) and on alternative lengthening of telomeres (ALT). ALT is associated with lower tumor grades and better outcome. In contrast to ALT, regulation of TA in tumors by direct mutation and epigenetic activation of the hTERT promoter is well established. Here, we summarize the genetic background of TMMs in non-malignant cells and in cancer, in addition to clinical and pathological features of gliomas...
May 17, 2017: Genes
https://www.readbyqxmd.com/read/28511658/global-kalman-filter-approaches-to-estimate-absolute-angles-of-lower-limb-segments
#6
Samuel L Nogueira, Stefan Lambrecht, Roberto S Inoue, Magdo Bortole, Arlindo N Montagnoli, Juan C Moreno, Eduardo Rocon, Marco H Terra, Adriano A G Siqueira, Jose L Pons
BACKGROUND: In this paper we propose the use of global Kalman filters (KFs) to estimate absolute angles of lower limb segments. Standard approaches adopt KFs to improve the performance of inertial sensors based on individual link configurations. In consequence, for a multi-body system like a lower limb exoskeleton, the inertial measurements of one link (e.g., the shank) are not taken into account in other link angle estimations (e.g., foot). Global KF approaches, on the other hand, correlate the collective contribution of all signals from lower limb segments observed in the state-space model through the filtering process...
May 16, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28508241/resource-use-and-real-world-outcomes-for-ranibizumab-treat-and-extend-for-neovascular-age-related-macular-degeneration-in-the-uk-interim-results-from-terra
#7
Yit Yang, Louise Downey, Hemal Mehta, Bushra Mushtaq, Niro Narendran, Nishal Patel, Praveen J Patel, Filis Ayan, Kara Gibson, Franklin Igwe, Pete Jeffery
INTRODUCTION: Ranibizumab is an inhibitor of vascular endothelial growth factor-A (anti-VEGF) approved for the treatment of neovascular age-related macular degeneration (nAMD). The treat and extend (T&E) regimen can potentially reduce the burden of clinic visits compared with a pro re nata (PRN) regimen. Retrospective, interim analyses of clinical effectiveness, treatment and resource use patterns were conducted using real-world data in England and Wales from the TERRA study. METHODS: Two cohorts, those switching from a PRN to a T&E regimen ('prior PRN') and those initiating ranibizumab on the T&E regimen as their first anti-VEGF therapy ('anti-VEGF-naïve') were enrolled in TERRA...
May 15, 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/28505168/development-and-validation-of-reversed-phase-hplc-gradient-method-for-the-estimation-of-efavirenz-in-plasma
#8
Shweta Gupta, Rajesh Kesarla, Narendra Chotai, Abdelwahab Omri
Efavirenz is an anti-viral agent of non-nucleoside reverse transcriptase inhibitor category used as a part of highly active retroviral therapy for the treatment of infections of human immune deficiency virus type-1. A simple, sensitive and rapid reversed-phase high performance liquid chromatographic gradient method was developed and validated for the determination of efavirenz in plasma. The method was developed with high performance liquid chromatography using Waters X-Terra Shield, RP18 50 x 4.6 mm, 3.5 μm column and a mobile phase consisting of phosphate buffer pH 3...
2017: PloS One
https://www.readbyqxmd.com/read/28490256/how-plastic-are-pericytes
#9
Alexander Birbrair, Isabella da Terra Borges, Isadora Fernandes Gilson Sena, Gregório Guilherme Almeida, Lindolfo da Silva Meirelles, Ricardo Gonçalves, Akiva Mintz, Osvaldo Delbono
Pericytes are defined by both their anatomical location and molecular markers. Numerous publications have reported their role as stem cells, contributing to the formation of tissues other than blood vessels. However, using cell-lineage tracing in a new transgenic mouse model, Guimarães-Camboa et al. (2017) show that in the context of aging and some pathologies, Tbx18+ pericytes do not function as stem cells in vivo. Their study challenges the current view that pericytes can differentiate into other cells and reopens questions about their plasticity...
May 10, 2017: Stem Cells and Development
https://www.readbyqxmd.com/read/28483657/immediate-effects-of-mirror-therapy-in-patients-with-shoulder-pain-and-decreased-range-of-motion
#10
Adriaan Louw, Emilio J Puentedura, Dave Reese, Paula Parker, Terra Miller, Paul Mintken
OBJECTIVE: To determine the effects of a brief single component of the graded motor imagery (GMI) sequence (mirror therapy) on active range of motion (AROM), pain, fear-avoidance and pain catastrophization in patients with shoulder pain. DESIGN: Single-blind case series SETTING: Three outpatient physical therapy clinics PARTICIPANTS: Patients with shoulder pain and limited AROM. INTERVENTIONS: Patients moved their unaffected shoulder through comfortable AROM in front of a mirror so that it appeared that they were moving their affected shoulder...
May 5, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28479340/pericytes-are-heterogeneous-in-their-origin-within-the-same-tissue
#11
Pedro Henrique Dias Moura Prazeres, Isadora Fernandes Gilson Sena, Isabella da Terra Borges, Patrick Orestes de Azevedo, Julia Peres Andreotti, Ana Emília de Paiva, Viviani Mendes de Almeida, Daniel Arthur de Paula Guerra, Gabryella Soares Pinheiro Dos Santos, Akiva Mintz, Osvaldo Delbono, Alexander Birbrair
Pericytes heterogeneity is based on their morphology, distribution, and markers. It is well known that pericytes from different organs may have distinct embryonic sources. Yamazaki et al. (2017) using several transgenic mouse model reveal by cell-lineage tracing that pericytes are even more heterogeneous than previously appreciated. This study shows that pericytes from within the same tissue may be heterogeneous in their origin. Remarkably, a subpopulation of embryonic dermal pericytes derives from the hematopoietic lineage, an unexpected source...
May 4, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28476193/molecular-characterization-of-pediatric-acute-myeloid-leukemia-results-of%C3%A2-a-multicentric-study-in-brazil
#12
Francianne Gomes Andrade, Elda Pereira Noronha, Gisele Dallapicola Brisson, Filipe Dos Santos Vicente Bueno, Ingrid Sardou Cezar, Eugênia Terra-Granado, Luiz Claudio Santos Thuler, Maria S Pombo-de-Oliveira
BACKGROUND AND AIMS: The biological characterization of childhood acute myeloid leukemia (c-AML) is an important outcome predictor. In Brazil, very little is known about the frequency of AML subgroups, although c-AML accounts for about 18% of leukemias. We carried out this study to investigate the contribution of type I and II gene mutations in the probability of overall survival (pOS) of c-AML in Brazil. METHODS: Seven hundred and three de novo pediatric AML cases (2000-2015) were assessed throughout a multicentric network study...
November 2016: Archives of Medical Research
https://www.readbyqxmd.com/read/28465792/effects-of-intermittent-fasting-on-health-markers-in-those-with-type-2-diabetes-a-pilot-study
#13
Terra G Arnason, Matthew W Bowen, Kerry D Mansell
AIM: To determine the short-term biochemical effects and clinical tolerability of intermittent fasting (IF) in adults with type 2 diabetes mellitus (T2DM). METHODS: We describe a three-phase observational study (baseline 2 wk, intervention 2 wk, follow-up 2 wk) designed to determine the clinical, biochemical, and tolerability of IF in community-dwelling volunteer adults with T2DM. Biochemical, anthropometric, and physical activity measurements (using the Yale Physical Activity Survey) were taken at the end of each phase...
April 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28460442/egfr-mediates-activation-of-ret-in-lung-adenocarcinoma-with-neuroendocrine-differentiation-characterized-by-ascl1-expression
#14
Kaustubh Bhinge, Lin Yang, Simone Terra, Aqsa Nasir, Prasuna Muppa, Marie Christine Aubry, Joanne Yi, Nafiseh Janaki, Irina V Kovtun, Stephen J Murphy, Geoffrey Halling, Hamed Rahi, Aaron Mansfield, Mariza de Andrade, Ping Yang, George Vasmatzis, Tobias Peikert, Farhad Kosari
Achaete-scute homolog 1 (ASCL1) is a neuroendocrine transcription factor specifically expressed in 10-20% of lung adenocarcinomas (AD) with neuroendocrine (NE) differentiation (NED). ASCL1 functions as an upstream regulator of the RET oncogene in AD with high ASCL1 expression (A+AD). RET is a receptor tyrosine kinase with two main human isoforms; RET9 (short) and RET51 (long). We found that elevated expression of RET51 associated mRNA was highly predictive of poor survival in stage-1 A+AD (p=0.0057). Functional studies highlighted the role of RET in promoting invasive properties of A+AD cells...
April 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28459507/molecular-recognition-of-a-carboxy-pyridostatin-towards-g-quadruplex-structures-why-does-it-prefer-rna
#15
Roberta Rocca, Carmine Talarico, Federica Moraca, Giosuè Costa, Isabella Romeo, Francesco Ortuso, Stefano Alcaro, Anna Artese
The pyridostatin (PDS) represents the lead compound of a family of G-quadruplex (G4) stabilizing synthetic small molecules based on a N,N'-bis(quinolinyl)pyridine-2,6-dicarboxamide scaffold. Its mechanism of action involves the induction of telomere dysfunction by competing for binding with telomere associated proteins, such as human POT1. Recently, through a template-directed 'in situ' click chemistry approach, a PDS derivative, the carboxypyridostatin (cPDS), was discovered. It has the peculiarity to exhibit high molecular specificity for RNA over DNA G4, while PDS is a good generic RNA and DNA G4-interacting small molecule...
April 29, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28458190/characterization-of-four-paenibacillus-species-isolated-from-pasteurized-chilled-ready-to-eat-meals
#16
Mariette Helmond, Masja N Nierop Groot, Hermien van Bokhorst-van de Veen
Food spoilage is often caused by microorganisms. The predominant spoilage microorganisms of pasteurized, chilled ready-to-eat (RTE) mixed rice-vegetable meals stored at 7°C were isolated and determined as Paenibacillus species. These sporeforming psychrotrophic bacteria are well adapted to grow in the starch-rich environment of pasteurized and chilled meals. Growth of the Paenibacillus isolates appeared to be delayed by decreased (<7°C) temperature or chilled temperature (7°C) combined with decreased pH (<5), increased sodium chloride (>5...
April 20, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/28454068/biochar-based-water-treatment-systems-as-a-potential-low-cost-and-sustainable-technology-for-clean-water-provision
#17
REVIEW
Willis Gwenzi, Nhamo Chaukura, Chicgoua Noubactep, Fungai N D Mukome
Approximately 600 million people lack access to safe drinking water, hence achieving Sustainable Development Goal 6 (Ensure availability and sustainable management of water and sanitation for all by 2030) calls for rapid translation of recent research into practical and frugal solutions within the remaining 13 years. Biochars, with excellent capacity to remove several contaminants from aqueous solutions, constitute an untapped technology for drinking water treatment. Biochar water treatment has several potential merits compared to existing low-cost methods (i...
April 25, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28452534/first-demonstration-of-electrostatic-damping-of-parametric-instability-at-advanced-ligo
#18
Carl Blair, Slawek Gras, Richard Abbott, Stuart Aston, Joseph Betzwieser, David Blair, Ryan DeRosa, Matthew Evans, Valera Frolov, Peter Fritschel, Hartmut Grote, Terra Hardwick, Jian Liu, Marc Lormand, John Miller, Adam Mullavey, Brian O'Reilly, Chunnong Zhao, B P Abbott, T D Abbott, C Adams, R X Adhikari, S B Anderson, A Ananyeva, S Appert, K Arai, S W Ballmer, D Barker, B Barr, L Barsotti, J Bartlett, I Bartos, J C Batch, A S Bell, G Billingsley, J Birch, S Biscans, C Biwer, R Bork, A F Brooks, G Ciani, F Clara, S T Countryman, M J Cowart, D C Coyne, A Cumming, L Cunningham, K Danzmann, C F Da Silva Costa, E J Daw, D DeBra, R DeSalvo, K L Dooley, S Doravari, J C Driggers, S E Dwyer, A Effler, T Etzel, T M Evans, M Factourovich, H Fair, A Fernández Galiana, R P Fisher, P Fulda, M Fyffe, J A Giaime, K D Giardina, E Goetz, R Goetz, C Gray, K E Gushwa, E K Gustafson, R Gustafson, E D Hall, G Hammond, J Hanks, J Hanson, G M Harry, M C Heintze, A W Heptonstall, J Hough, K Izumi, R Jones, S Kandhasamy, S Karki, M Kasprzack, S Kaufer, K Kawabe, N Kijbunchoo, E J King, P J King, J S Kissel, W Z Korth, G Kuehn, M Landry, B Lantz, N A Lockerbie, A P Lundgren, M MacInnis, D M Macleod, S Márka, Z Márka, A S Markosyan, E Maros, I W Martin, D V Martynov, K Mason, T J Massinger, F Matichard, N Mavalvala, R McCarthy, D E McClelland, S McCormick, G McIntyre, J McIver, G Mendell, E L Merilh, P M Meyers, R Mittleman, G Moreno, G Mueller, J Munch, L K Nuttall, J Oberling, P Oppermann, Richard J Oram, D J Ottaway, H Overmier, J R Palamos, H R Paris, W Parker, A Pele, S Penn, M Phelps, V Pierro, I Pinto, M Principe, L G Prokhorov, O Puncken, V Quetschke, E A Quintero, F J Raab, H Radkins, P Raffai, S Reid, D H Reitze, N A Robertson, J G Rollins, V J Roma, J H Romie, S Rowan, K Ryan, T Sadecki, E J Sanchez, V Sandberg, R L Savage, R M S Schofield, D Sellers, D A Shaddock, T J Shaffer, B Shapiro, P Shawhan, D H Shoemaker, D Sigg, B J J Slagmolen, B Smith, J R Smith, B Sorazu, A Staley, K A Strain, D B Tanner, R Taylor, M Thomas, P Thomas, K A Thorne, E Thrane, C I Torrie, G Traylor, G Vajente, G Valdes, A A van Veggel, A Vecchio, P J Veitch, K Venkateswara, T Vo, C Vorvick, M Walker, R L Ward, J Warner, B Weaver, R Weiss, P Weßels, B Willke, C C Wipf, J Worden, G Wu, H Yamamoto, C C Yancey, Hang Yu, Haocun Yu, L Zhang, M E Zucker, J Zweizig
Interferometric gravitational wave detectors operate with high optical power in their arms in order to achieve high shot-noise limited strain sensitivity. A significant limitation to increasing the optical power is the phenomenon of three-mode parametric instabilities, in which the laser field in the arm cavities is scattered into higher-order optical modes by acoustic modes of the cavity mirrors. The optical modes can further drive the acoustic modes via radiation pressure, potentially producing an exponential buildup...
April 14, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28446040/characteristics-of-socially-withdrawn-youth-in-france-a-retrospective-study
#19
Nicolas Chauliac, Audrey Couillet, Sophie Faivre, Nassima Brochard, Jean-Louis Terra
BACKGROUND: Poor social interactions have been recognized as a symptom since the beginnings of psychiatry. As far as socially withdrawn youth (SWY) are concerned, studies were mostly conducted on patients seeking care. Our psychiatric outreach team called Psymobile was able to reach SWY patients who were not seeking mental health care. AIMS: To identify the clinical and socio-demographic characteristics of SWY patients referred to our Psymobile unit. METHOD: We carried out a retrospective study on the records of patients aged 18-34 years, who were referred to Psymobile for 'withdrawal', between April 2012 and December 2015...
April 1, 2017: International Journal of Social Psychiatry
https://www.readbyqxmd.com/read/28443993/work-accidents-and-self-esteem-of-nursing-professional-in-hospital-settings
#20
Sérgio Valverde Marques Dos Santos, Flávia Ribeiro Martins Macedo, Luiz Almeida da Silva, Zelia Marilda Rodrigues Resck, Denismar Alves Nogueira, Fábio de Souza Terra
OBJECTIVE: to analyze the occurrence of work accidents and the self-esteem of nurses in hospitals of a municipality of Minas Gerais. METHOD: descriptive-analytical and cross-sectional study developed with 393 nursing professionals from three hospitals of a municipality in southern Minas Gerais. The Rosenberg Self-Esteem Scale and a questionnaire to characterize the population and work accidents were used for data collection. Data analysis was performed using Person's chi-squared test, Fisher's exact test, Cronbach's alpha, odds ratio and logistic regression...
April 20, 2017: Revista Latino-americana de Enfermagem
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