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Michael Howard Baca-Atlas, Amir Homayoun Barzin
A 66-year-old man with a history of renal transplant on chronic immunosuppression presented to his primary care physician with a swollen right index finger. On examination, mild swelling was present. Conservative management failed and initial plain films were negative. Corticosteroid injection was performed by orthopaedics, but symptoms recurred several months later and an MRI showed flexor digitorum tenosynovitis and abscesses of the superficialis and profundus tendons. A flexor tenolysis was performed with cultures positive for Mycobacterium szulgai , a rare, non-tuberculous mycobacterial infection...
December 22, 2017: BMJ Case Reports
Hui Pang, Yi Jiang, Kanglin Wan
Objectives. Slowly growing mycobacteria (SGM) are prevalent worldwide and cause an extensive spectrum of diseases. Methods. In this study, the antimicrobial susceptibility of 33 reference strains of SGM to 19 antimicrobial agents was tested using a modified microdilution method. Results. Cefmetazole (32/33) and azithromycin (32/33) exhibited the highest antimicrobial activity, and dapsone (9/33) exhibited the lowest activity against the tested strains. Cefoxitin (30/33), cefoperazone (28/33), and cefepime (28/33) were effective against a high proportion of strains, and macrolides were also highly effective as well as offering the benefit of convenient oral administration to patients...
2017: BioMed Research International
Angela Bartolf, Catherine A Cosgrove
A 53-year-old woman was identified with Mycobacterium szulgai infection in the flexor sheath of the right index finger. Tissue was debrided at operation, and the patient was successfully treated with appropriate antimicrobials. M. szulgai is a rare cause of non-tubercular mycobacterium infection worldwide, and there are currently no clear guidelines on diagnosis and management. This is the first case reporting M. szulgai infection in the flexor sheath of the right index finger of a non-immunocompromised patient in the UK...
March 13, 2017: BMJ Case Reports
Satoshi Hamada, Eiichi Hayashi, Mitsuhiro Tsukino
No abstract text is available yet for this article.
March 6, 2017: Archivos de Bronconeumología
Yamrot M Amha, M Zohaib Anwar, Rajkumari Kumaraswamy, Andreas Henschel, Farrukh Ahmad
With accumulating evidence of pulmonary infection via aerosolized nontuberculous mycobacteria (NTM), it is important to characterize their persistence in wastewater treatment, especially in arid regions where treated municipal wastewater is extensively reused. To achieve this goal, microbial diversity of the genus Mycobacterium was screened for clinically and environmentally relevant species using pyrosequencing. Analysis of the postdisinfected treated wastewater showed the presence of clinically relevant slow growers like M...
March 7, 2017: Environmental Science & Technology
Ana Milagro Beamonte, Elena Briz Muñoz, Luis Torres Sopena, Luis Borderías Clau
No abstract text is available yet for this article.
December 21, 2016: Archivos de Bronconeumología
S Khan, N Clerk, K Galloway, R Mustafa, G Antunes
No abstract text is available yet for this article.
July 2016: QJM: Monthly Journal of the Association of Physicians
Hongfei Duan, Guan Liu, Xiaobo Wang, Yuhong Fu, Qian Liang, Yuanyuan Shang, Naihui Chu, Hairong Huang
OBJECTIVES: To evaluate the resolution and reliability of the rpsA gene, encoding ribosomal protein S1, as a novel biomarker for mycobacteria species identification. METHODS: A segment of the rpsA gene (565 bp) was amplified by PCR from 42 mycobacterial reference strains, 172 nontuberculosis mycobacteria clinical isolates, and 16 M. tuberculosis complex clinical isolates. The PCR products were sequenced and aligned by using the multiple alignment algorithm in the MegAlign package (DNASTAR) and the MEGA program...
2015: BioMed Research International
Amresh Kumar Singh, Rungmei S K Marak, Anand Kumar Maurya, Manaswini Das, Vijaya Lakshmi Nag, Tapan N Dhole
Nontuberculous mycobacteria (NTMs) are ubiquitous and are being increasingly reported as human opportunistic infection. Cutaneous infection caused by mixed NTM is extremely rare. We encountered the case of a 46-year-old female, who presented with multiple discharging sinuses over the lower anterior abdominal wall (over a previous appendectomy scar) for the past 2 years. Microscopy and culture of the pus discharge were done to isolate and identify the etiological agent. Finally, GenoType Mycobacterium CM/AS assay proved it to be a mixed infection caused by Mycobacterium szulgai and M...
2015: Case Reports in Dermatological Medicine
Julie V Philley, David E Griffith
The most common nontuberculous mycobacterial (NTM) lung pathogen, Mycobacterium avium complex (MAC), requires antibiotic treatment regimens that are long and often arduous. M kansasii is the slowly growing NTM pathogen with the most predictably successful treatment outcomes, whereas other slowly growing NTM pathogens such as M xeonpi, M szulgai, and M malmoense are less predictably responsive to antibiotic regimens. M simiae is the most difficult of the common slowly growing NTM pathogens to eradicate. Surgical intervention for slowly growing mycobacterial lung infection has proved beneficial for some patients, but the optimal candidates and timing for surgical intervention remain unknown...
March 2015: Clinics in Chest Medicine
Jeong Jae Kim, Jaechun Lee, Sun Young Jeong
Mycobacterium szulgai (M. szulgai) is an unusual pathogen in a human non-tuberculous mycobacterial infection. Pulmonary infection due to M. szulgai may be clinically and radiologically confused with active pulmonary tuberculosis. In contrast to other non-tuberculous mycobacteria, M. szulgai infection is well controlled by combination antimycobacterial therapy. Most of the previously reported cases of M. szulgai pulmonary infection showed cavitary upper lobe infiltrates. We herein describe a case of pulmonary M...
September 2014: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
S G Chong, B D Kent, S Fitzgerald, T J McDonnell
The prevalence of non-tuberculous mycobacterium (NTM) appears to be increasing. Much of the experience in the literature about this emerging organism comes from specialised units or populations such as cystic fibrosis patients. We, therefore, aim to evaluate the experience in a general respiratory population of dealing with patients with positive culture of NTM. We did a retrospective review of medical notes of general respiratory patients from whom NTM were isolated from January 2007 to July 2012. Cystic fibrosis patients were excluded...
July 2014: Irish Medical Journal
Mohammed A Alqumber
OBJECTIVE: To investigate for the presence of mycobacteria at water dams of Albaha, Saudi Arabia. METHODS: An epidemiological study was conducted between 20 - 30 June 2013 in the Albaha region, Kingdom of Saudi Arabia. Five hundred and twenty samples (sand, wet stones, clay, and decayed vegetation) were collected from 13 dams in the region. These locations were: 3 dams from Alaqiq city (Thrad, Alaqiq, and Almshereq); 4 dams from Almandaq city (Almudlamat, Alkhrar, Alsader, and Medhas); one dam from Albaha city (Shehba'a); and 5 dams from Baljerashi city (Alzarawah, Alareshaen, Almatwah, Alheajh, and Almarbah)...
May 2014: Saudi Medical Journal
Oded Shamriz, Dan Engelhard, Andrea Psorn Rajs, Hasia Kaidar-Shwartz, Jean-Laurent Casanova, Diana Averbuch
We report a 17-year-old patient with inherited STAT1 deficiency, who was diagnosed with Mycobacterium szulgai chronic multifocal osteomyelitis and responded well to the therapy with ethambutol, rifampicin and azithromycin. Seven other reported cases of M. szulgai osteomyelitis are reviewed. This is the first description of M. szulgai osteomyelitis in an adolescent with a primary immunodeficiency.
December 2013: Pediatric Infectious Disease Journal
Hongseok Yoo, Kyeongman Jeon, Su-Young Kim, Byeong-Ho Jeong, Hye Yun Park, Chang-Seok Ki, Nam Yong Lee, Sung Jae Shin, Won-Jung Koh
BACKGROUND: The clinical relevance of Mycobacterium szulgai respiratory isolates has been controversial. The aim of this study was to determine the clinical significance of M. szulgai isolates from respiratory specimens and to identify the clinical features and outcomes of M. szulgai lung disease. METHODS: We reviewed the medical records of 30 patients from whom M. szulgai was isolated between 2001 and 2010 at the Samsung Medical Center (Seoul, Korea). RESULTS: Of the 30 patients, 13 (43%) met the American Thoracic Society diagnostic criteria and were thus likely to have true M...
March 2014: Scandinavian Journal of Infectious Diseases
Oded Shamriz, Dan Engelhard, Andrea Psorn Rajs, Hasia Kaidar-Shwartz, Jean-Laurent Casanova, Diana Averbuch
We report a 17-year-old patient with inherited STAT1 deficiency, who was diagnosed with Mycobacterium szulgai chronic multifocal osteomyelitis and responded well to therapy with ethambutol, rifampicin and azithromycin. Seven other reported cases of M. szulgai osteomyelitis are reviewed. This is the first description of M. szulgai osteomyelitis in an adolescent with a primary immunodeficiency.
September 20, 2013: Pediatric Infectious Disease Journal
Jae Sun Park, Jung-In Choi, Ji-Hun Lim, Jong-Joon Ahn, Yangjin Jegal, Kwang Won Seo, Seung Won Ra, Jae Bum Jeon, Seon Ho Lee, Sung-Ryul Kim, Joseph Jeong
We used HPLC and AdvanSure real-time PCR (LG Life Sciences, Korea) to retrospectively analyze non-tuberculous mycobacteria (NTM) in 133 clinical specimens. The specimens were culture-positive for NTM and the HPLC method identified 130 strains of mycobacteria from the cultures (97.7%) at the species level. Among the isolates, 48 Mycobacterium. kansasii (36.1%), 39 M. intracellulare (29.3%), 17 M. avium (12.8%), 16 M. abscessus (12.0%), 6 M. fortuitum (4.5%), 2 M. szulgai (1.5%), 2 M. gordonae (1.5%), and 3 unclassified NTM strains (2...
September 2013: Annals of Laboratory Medicine
Cleoni Alves Mendes de Lima, Harrison Magdinier Gomes, Maraníbia Aparecida Cardoso Oelemann, Jesus Pais Ramos, Paulo Cezar Caldas, Carlos Eduardo Dias Campos, Márcia Aparecida da Silva Pereira, Fátima Fandinho Onofre Montes, Maria do Socorro Calixto de Oliveira, Philip Noel Suffys, Maria Manuela da Fonseca Moura
The main cause of pulmonary tuberculosis (TB) is infection with Mycobacterium tuberculosis (MTB). We aimed to evaluate the contribution of nontuberculous mycobacteria (NTM) to pulmonary disease in patients from the state of Rondônia using respiratory samples and epidemiological data from TB cases. Mycobacterium isolates were identified using a combination of conventional tests, polymerase chain reaction-based restriction enzyme analysis of hsp65 gene and hsp65 gene sequencing. Among the 1,812 cases suspected of having pulmonary TB, 444 yielded bacterial cultures, including 369 cases positive for MTB and 75 cases positive for NTM...
June 2013: Memórias do Instituto Oswaldo Cruz
Tushar Chopra, William Gibbons, Anil Patel, James Yossef
SESSION TYPE: Infectious Disease Student/Resident Case Report Posters IIIPRESENTED ON: Tuesday, October 23, 2012 at 01:30 PM - 02:30 PMINTRODUCTION: Mycobacterium szulgai, a non-tuberculous mycobacterium (NTM) is a rarely isolated scotochromogen. It is acquired through the lungs from an unknown environmental source. There are under 100 reported cases, most of whom had tuberculosis-like pulmonary disease. Infection occurs in patients with pre-existing lung disease (e.g. tuberculosis, COPD) and in immunocompromised hosts...
October 1, 2012: Chest
Rachel M Thomson, Robyn Carter, Carla Tolson, Chris Coulter, Flavia Huygens, Megan Hargreaves
BACKGROUND: Nontuberculous mycobacteria (NTM) are normal inhabitants of a variety of environmental reservoirs including natural and municipal water. The aim of this study was to document the variety of species of NTM in potable water in Brisbane, QLD, with a specific interest in the main pathogens responsible for disease in this region and to explore factors associated with the isolation of NTM. One-litre water samples were collected from 189 routine collection sites in summer and 195 sites in winter...
2013: BMC Microbiology
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