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https://www.readbyqxmd.com/read/28629501/mycobacterium-persicum-sp-nov-a-novel-species-closely-related-to-mycobacterium-kansasii-and-mycobacterium-gastri
#1
Abdolrazagh Hashemi Shahraki, Alberto Trovato, Mehdi Mirsaeidi, Emanuele Borroni, Parvin Heidarieh, Mohamad Hashemzadeh, Narges Shahbazi, Daniela M Cirillo, Enrico Tortoli
Four strains isolated in Iran from pulmonary specimens of unrelated patients are proposed as representative of a novel Mycobacterium species. Similarity, at the phenotypic level, with Mycobacterium kansasii is remarkable with the photochromogenic yellow pigmentation of the colonies being the salient feature. They differ, however, genotypically from this species and present unique sequences in 16S rRNA, hsp65 and rpoB genes. The average nucleotide identity and the genome-to-genome distance fully support the status of an independent species...
June 20, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28619015/nontuberculosis-mycobacterial-infections-at-a-specialized-tuberculosis-treatment-centre-in-the-republic-of-korea
#2
Hee Jung Yoon, Hwa Young Choi, Moran Ki
BACKGROUND: The incidence of nontuberculous mycobacteria (NTM) infections is increasing worldwide, however formal evaluations of the epidemiology of NTM infections are limited. Understanding the trends and true prevalence of NTM is a major priority for optimizing infection control programmes and resources. The purpose of this study was to investigate the epidemiology, clinical manifestations, and radiologic findings in NTM-infected patients at specialized Tuberculosis (Tb) treatment centre in South Korea, which is endemic to Tb, and find solutions to control NTM infections...
June 15, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28588774/solitary-pulmonary-caseating-granulomas-a-5-year-retrospective-single-center-analysis
#3
Hidehiro Watanabe, Tomonori Uruma, Ikuo Seita, Tsuyoshi Oishi, Yusuke Watanabe, Ayaka Tsukimori, Yoshiteru Haga, Shinji Fukushima, Akihiro Sato, Itaru Nakamura, Tetsuya Matsumoto
Solitary pulmonary caseating granulomas (SPCGs) are a characteristic type of tuberculomas associated with infection with non-tuberculous mycobacteria (NTM) and other microbes; however, their significance remains unclear. The aim of the present study was to describe the clinical characteristics of patients with SPCGs in terms of diagnosis, presence of lung cancer and treatment status. A retrospective analysis of 17 immunocompetent patients with histopathologically confirmed caseating granulomas after undergoing video-assisted thoracoscopic surgery (VATS) was conducted at our center between 2011 and 2015...
June 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28572311/draft-genome-sequences-of-mycobacterium-kansasii-clinical-strains
#4
Paulina Borówka, Jakub Lach, Zofia Bakuła, Jakko van Ingen, Aleksandra Safianowska, Anna Brzostek, Jarosław Dziadek, Dominik Strapagiel, Tomasz Jagielski
Mycobacterium kansasii is a nontuberculous mycobacterial (NTM) pathogen, frequently isolated from clinical samples and responsible for a large part of NTM infections in the human population. Here, we report the draft genome sequences of 12 M. kansasii strains isolated from clinical and host-associated sources from the Netherlands, Germany, and Poland.
June 1, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28550962/hiv-and-mycobacteria
#5
REVIEW
Gary W Procop
The importance of mycobacteria as opportunistic pathogens, particularly members of the M. avium complex (MAC), in patients with progressive HIV infection was recognized early in the AIDS epidemic. It took longer to appreciate the global impact and devastation that would result from the deadly synergy that exists between HIV and M. tuberculosis. This HIV/M. tuberculosis co-pandemic is ongoing and claiming millions of lives every year. In addition to MAC, a number of other non-tuberculous mycobacteria have been recognized as opportunistic pathogens in HIV-infected individuals; some of these are more commonly encountered (e...
July 2017: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/28529884/osteomyelitis-due-to-mycobacterium-kansasii-in-a-patient-with-sarcoidosis
#6
N van Herwaarden, H Bavelaar, R Janssen, A Werre, A Dofferhoff
No abstract text is available yet for this article.
2017: IDCases
https://www.readbyqxmd.com/read/28508743/mycobacterium-kansasii-isolated-from-tuberculinpositive-rhesus-macaques-macaca-mulatta-in-the-absence-of-disease
#7
Steven T Shipley, David K Johnson, Morteza Roodgar, David Glenn Smith, Charles A Montgomery, Steven M Lloyd, James A Higgins, Edwin H Kriel, Hilton J Klein, William P Porter, Jerome B Nazareno, Paul W Houghton, Aruna Panda, Louis J DeTolla
Mycobacterial infections are of primary health concern in NHP colonies in biomedical research. NHP are constantly monitoredand screened for Mycobacterium spp. We report 6 Chinese-origin rhesus macaques infected with Mycobacterium kansasii thatexhibited positive tuberculin skin tests in the absence of disease. Two of these macaques were being used for research purposes;the remaining 4 macaques were residing at the contract quarantine company. Histopathology and acid-fast staining of fixed tissues from all macaques showed that all were free of disease...
May 15, 2017: Comparative Medicine
https://www.readbyqxmd.com/read/28468858/misidentification-of-mycobacterium-paraense-as-mycobacterium-avium-complex-by-accuprobe
#8
LETTER
Husain Poonawala, Vincent E Piscitelli, Lynn Ladutko, Sheldon Campbell
No abstract text is available yet for this article.
July 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28465507/the-role-of-hydrophobicity-in-tuberculosis-evolution-and-pathogenicity
#9
Monika Jankute, Vijayashankar Nataraj, Oona Y-C Lee, Houdini H T Wu, Malin Ridell, Natalie J Garton, Michael R Barer, David E Minnikin, Apoorva Bhatt, Gurdyal S Besra
The evolution of tubercle bacilli parallels a route from environmental Mycobacterium kansasii, through intermediate "Mycobacterium canettii", to the modern Mycobacterium tuberculosis complex. Cell envelope outer membrane lipids change systematically from hydrophilic lipooligosaccharides and phenolic glycolipids to hydrophobic phthiocerol dimycocerosates, di- and pentaacyl trehaloses and sulfoglycolipids. Such lipid changes point to a hydrophobic phenotype for M. tuberculosis sensu stricto. Using Congo Red staining and hexadecane-aqueous buffer partitioning, the hydrophobicity of rough morphology M...
May 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28461147/microbiological-and-clinical-outcomes-of-treating-non-mac-ntm-pulmonary-disease-a-systematic-review-and-meta-analysis
#10
R Diel, F C Ringshausen, E Richter, L Welker, J Schmitz, A Nienhaus
BACKGROUND: Pulmonary disease caused by non-tuberculous mycobacteria (NTM) is steadily increasing worldwide. METHODS: A systematic review of Non-Mycobacterium avium complex studies published prior to October 2016 was conducted with respect to microbiological and clinical outcomes of current treatment regimens. RESULTS: We retrieved 352 citations; these yielded 24 studies eligible for evaluation. Sixteen studies were retrospective chart reviews, 3 were prospective and only 5 randomized...
April 28, 2017: Chest
https://www.readbyqxmd.com/read/28433210/non-tuberculous-mycobacteria-an-emerging-threat
#11
Susana Martínez González, Arantxa Cano Cortés, Luis Alfonso Sota Yoldi, José María García García, Luz María Alba Álvarez, Juan José Palacios Gutiérrez
INTRODUCTION AND OBJECTIVE: Non-tuberculous mycobacteria (NTM) isolates are becoming more common. The main objective of our study was to establish the number and diversity of NTM species in our region and their distribution according to the source sample, age and gender of the patients, and to analyse clinically significant isolates. METHODOLOGY: Prospective study of all NTM isolated in Asturias from 2005 to 2012. Samples were processed following internationally accepted guidelines...
April 19, 2017: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/28428296/complete-genome-sequences-of-mycobacterium-kansasii-strains-isolated-from-rhesus-macaques
#12
Aruna Panda, Sushma Nagaraj, Xuechu Zhao, Hervé Tettelin, Louis J DeTolla
Mycobacterium kansasii is a nontuberculous mycobacterium. It causes opportunistic infections with pulmonary and extrapulmonary manifestations. We report here the complete genome sequences of two M. kansasii strains isolated from rhesus macaques. We performed genome comparisons with human and environmental isolates of M. kansasii to assess the genomic diversity of this species.
April 20, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28387523/species-specific-risk-factors-treatment-decisions-and-clinical-outcomes-for-laboratory-isolates-of-less-common-nontuberculous-mycobacteria-in-washington-state
#13
Emily S Ford, David J Horne, Javeed A Shah, Carolyn K Wallis, Ferric C Fang, Thomas R Hawn
RATIONALE: Nontuberculous mycobacteria are a diverse group of environmental organisms that infrequently cause human disease. Understanding the epidemiologic and clinical characteristics associated with nontuberculous mycobacterial disease is needed to refine diagnostic and treatment strategies, particularly among the less commonly isolated species. OBJECTIVES: To improve knowledge of geographic variance of nontuberculous mycobacteria (NTM) species, to correlate detailed clinical information with isolation of specific NTM, and to examine the decision to treat and outcomes for specific NTM...
April 7, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28350331/novel-sulfamethoxazole-ureas-and-oxalamide-as-potential-antimycobacterial-agents
#14
Martin Krátký, Jiřina Stolaříková, Jarmila Vinšová
Infections caused by Mycobacterium tuberculosis (Mtb.) and nontuberculous mycobacteria (NTM) are considered to be a global health problem; current therapeutic options are limited. Sulfonamides have exhibited a wide range of biological activities including those against mycobacteria. Based on the activity of 4-(3-heptylureido)-N-(5-methylisoxazol-3-yl)benzenesulfonamide against NTM, we designed a series of homologous sulfamethoxazole-based n-alkyl ureas (C₁-C12), as well as several related ureas and an oxalamide...
March 28, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28348502/nontuberculous-mycobacteria-in-saudi-arabia-and-gulf-countries-a-review
#15
REVIEW
Hawra Al-Ghafli, Sahal Al-Hajoj
Nontuberculous Mycobacteria (NTM) are causing growing health problems worldwide. This is indicated by an increasing amount of scientific reports showing not only well-identified species reemerging but also emergence of new species. The emergence and reemergence of NTM are particularly worrying in developing countries due to scarce published data and improper identification. Here we aimed to examine the main epidemiological aspects and diagnostic challenges associated with NTM in countries of the Gulf Cooperation Council (GCC) and compare these findings to the international arena findings...
2017: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/28342513/mycotic-aortic-pseudoaneurysms-in-a-patient-with-active-mycobacterium-kansasii-infection
#16
Stefan Kénel-Pierre, Keith M Jones, Jorge Rey, Handel R Robinson
No abstract text is available yet for this article.
April 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28331837/public-health-relevance-of-non-tuberculous-mycobacteria-among-afb-positive-sputa
#17
Prabha Desikan, Karuna Tiwari, Nikita Panwalkar, Saima Khaliq, Manju Chourey, Reeta Varathe, Shaina Beg Mirza, Arun Sharma, Sridhar Anand, Manoj Pandey
BACKGROUND: Sputum smear microscopy for acid fast bacilli (AFB) is used by most public health programmes to detect tuberculosis. While most AFB in countries endemic for tuberculosis are Mycobacterium tuberculosis (MTB), some may also be non-tuberculous mycobacteria (NTM). The inability to differentiate NTM from MTB by sputum smear microscopy may lead to erroneous diagnoses of tuberculosis, leading in turn to inappropriate therapy. METHODS: This was a retrospective study of consecutive sputum samples received from November 2013 to March 2015 in the Department of Microbiology, Bhopal Memorial Hospital & Research Centre, Bhopal, India...
March 2017: Germs
https://www.readbyqxmd.com/read/28330892/in-vitro-susceptibility-testing-of-tedizolid-against-nontuberculous-mycobacteria
#18
Barbara A Brown-Elliott, Richard J Wallace
Tedizolid is a new oxazolidinone with improved in vitro and intracellular potency against Mycobacterium tuberculosis, including multidrug-resistant strains, and some species of nontuberculous mycobacteria (NTM) compared with that of linezolid. Using the current Clinical and Laboratory Standards Institute (CLSI)-recommended method of broth microdilution, susceptibility testing of 170 isolates of rapidly growing mycobacteria showed equivalent or lower (1- to 8-fold) MIC50 and/or MIC90 values for tedizolid compared with that for linezolid...
June 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28317629/mycobacterium-kansasii-infection-in-a-patient-receiving-biologic-therapy-not-all-reactive-interferon-gamma-release-assays-are-tuberculosis
#19
Nasir Saleem, Raya Saba, Srikanth Maddika, Mitchell Weinstein
Mycobacterium kansasii, a nontuberculous mycobacterium, can lead to lung disease similar to tuberculosis. Immunotherapeutic biologic agents predispose to infections with mycobacteria, including M kansasii. T-cell-mediated interferon gamma release assays like QuantiFERON-TB Gold Test (QFT) are widely used by clinicians for the diagnosis of infections with Mycobacterium tuberculosis; however, QFT may also show positive result with certain nontuberculous mycobacterial infections. We report a case of M kansasii pulmonary infection, with a positive QFT, in an immunocompromised patient receiving prednisone, leflunomide and tocilizumab, a humanized anti-interleukin-6 receptor monoclonal antibody...
April 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28297817/-distribution-and-drug-resistance-of-nontuberculous-mycobacteria-in-beijing
#20
J Zhang, J R Su, B C Ding, J W Liu, J L Yi, X Y Yang, N H Wang, S M Wang
Objective: To analyze the distribution and drug resistance of nontuberculous mycobacteria(NTM) in Beijing. Methods: Using PCR-fluorescence probe method we identified 1 552 mycobacterial isolates in 2009 and 1 553 mycobacterial isolates in 2013, which were stored by Beijing Research Institute for Tuberculosis Control.All identified NTM strains were confirmed by 16S rRNA gene sequencing, and drug sensitivity testing was performed by using 1% ratio method.SPSS 13.0 was used for statistical analysis. Results: The isolation rate for NTM in 2009 and 2013 was 3...
March 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
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