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https://www.readbyqxmd.com/read/29441757/changing-epidemiology-of-nontuberculous-mycobacterial-lung-diseases-in-a-tertiary-referral-hospital-in-korea-between-2001-and-2015
#1
Ryoung Eun Ko, Seong Mi Moon, Soohyun Ahn, Byung Woo Jhun, Kyeongman Jeon, O Jung Kwon, Hee Jae Huh, Chang Seok Ki, Nam Yong Lee, Won Jung Koh
This study investigated the changes in the major etiologic organisms and clinical phenotypes of nontuberculous mycobacterial lung disease (NTM-LD) over a recent 15-year period in Korea. The increase of number of patients with NTM-LD was primarily due to an increase of Mycobacterium avium complex (MAC) lung disease (LD). Among MAC cases, the proportion of M. avium increased compared with M. intracellulare, whereas the incidence of M. abscessus complex and M. kansasii LD remained relatively stable. The proportion of cases of the nodular bronchiectatic form increased compared with the fibrocavitary form of NTM-LD...
February 19, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29384899/coinfection-of-disseminated-talaromyces-marneffei-and-mycobacteria-kansasii-in-a-patient-with-papillary-thyroid-cancer-a-case-report
#2
Jing Zhang, Xinyan Huang, Xin Zhang, Ying Zhu, Kang Liao, Jing Ma, Guangfa Wang, Yubiao Guo, Canmao Xie
RATIONALE: Recently, Talaromyces marneffei (T. marneffei) has been reported in human immunodeficiency virus (HIV)-negative patient with underlying diseases, such as oral cancer, colon cancer, haematological malignancies, connective tissue disease, diabetes mellitus, and corticosteroids or immunosuppressive agents. Similar to HIV-positive ones, such patients were observed with CD4 lymphocytopenia. PATIENT CONCERNS: We reported a case of a 45-year-old woman who was diagnosed with disseminated T...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29343612/structural-and-functional-characterisation-of-the-cytochrome-p450-enzyme-cyp268a2-from-mycobacterium-marinum
#3
Stella A Child, Elise F Naumann, John B Bruning, Stephen G Bell
Members of the cytochrome P450 monooxygenase family CYP268 are found across a broad range of Mycobacterium species including the pathogens Mycobacterium avium, M. colombiense,M. kansasii and Mmarinum CYP268A2, from M. marinum , which is the first member of this family to be studied, was purified and characterised. CYP268A2 was found to bind a variety of substrates with high affinity, including branched and straight-chain fatty acids (C10-C12), acetate esters, and aromatic compounds. The enzyme was also found to bind phenylimidazole inhibitors but not larger azoles, such as ketoconazole...
January 17, 2018: Biochemical Journal
https://www.readbyqxmd.com/read/29274237/lipase-catalyzed-kinetic-resolution-of-novel-antitubercular-benzoxazole-derivatives
#4
Edyta Łukowska-Chojnacka, Anna Kowalkowska, Agnieszka Napiórkowska
Novel benzoxazole derivatives were synthesized, and their antitubercular activity against sensitive and drug-resistant Mycobacterium tuberculosis strains (M. tuberculosis H37 Rv, M. tuberculosis sp. 210, M. tuberculosis sp. 192, Mycobacterium scrofulaceum, Mycobacterium intracellulare, Mycobacterium fortuitum, Mycobacterium avium, and Mycobacterium kansasii) was evaluated. The chemical step included preparation of ketones, alcohols, and esters bearing benzoxazole moiety. All racemic mixtures of alcohols and esters were separated in Novozyme SP 435-catalyzed transesterification and hydrolysis, respectively...
December 23, 2017: Chirality
https://www.readbyqxmd.com/read/29250924/non-tuberculous-mycobacteria-isolated-from-lymph-nodes-and-faecal-samples-of-healthy-slaughtered-cattle-and-the-abattoir-environment
#5
G Ghielmetti, U Friedel, S Scherrer, E Sarno, P Landolt, O Dietz, M Hilbe, C Zweifel, R Stephan
Infections caused by non-tuberculous mycobacteria (NTM) are reported as emerging disease in many countries worldwide. The occurrence of NTM in different hosts and their implication as obligate or opportunistic pathogen remain largely unclear. Lymph nodes and faecal samples of clinically healthy Swiss cattle at slaughter were analysed for the presence of NTM. Based on the examined lymph nodes, NTM were detected in 20% of 108 cattle originating from different premises. The 22 isolates belonged to five different species of Mycobacteria (M...
December 17, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29189762/synthesis-and-in-vitro-antimycobacterial-activity-of-novel-n-arylpiperazines-containing-an-ethane-1-2-diyl-connecting-chain
#6
Tomáš Goněc, Ivan Malík, Jozef Csöllei, Josef Jampílek, Jiřina Stolaříková, Ivan Solovič, Peter Mikuš, Stanislava Keltošová, Peter Kollár, Jim O'Mahony, Aidan Coffey
Novel 1-(2-{3-/4-[(alkoxycarbonyl)amino]phenyl}-2-hydroxyethyl)-4-(2-fluorophenyl)-piperazin-1-ium chlorides (alkoxy = methoxy to butoxy; 8a-h) have been designed and synthesized through multistep reactions as a part of on-going research programme focused on finding new antimycobacterials. Lipophilic properties of these compounds were estimated by RP-HPLC using methanol/water mobile phases with a various volume fraction of the organic modifier. The log kw values, which were extrapolated from intercepts of a linear relationship between the logarithm of a retention factor k (log k) and volume fraction of a mobile phase modifier (ϕM), varied from 2...
November 30, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29188063/high-rates-of-nontuberculous-mycobacteria-isolation-from-patients-with-presumptive-tuberculosis-in-iran
#7
M J Nasiri, H Dabiri, A A I Fooladi, S Amini, G Hamzehloo, M M Feizabadi
Nontuberculous mycobacteria (NTM) can cause disease which can be indistinguishable from tuberculosis (TB), posing a diagnostic and therapeutic challenge, particularly in low- and middle-income settings. We aimed to investigate the mycobacterial agents associated with presumptive clinical pulmonary TB in Iran. A total of 410 mycobacterial isolates, obtained between March 2014 and January 2016, from 7600 clinical samples taken from consecutive cases of presumptive diagnosis of TB were identified. Phenotypic and molecular tests were used to identify the isolated organisms to the species level...
January 2018: New Microbes and New Infections
https://www.readbyqxmd.com/read/29176894/horizontal-acquisition-of-a-hypoxia-responsive-molybdenum-cofactor-biosynthesis-pathway-contributed-to-mycobacterium-tuberculosis-pathoadaptation
#8
Florence Levillain, Yannick Poquet, Ludovic Mallet, Serge Mazères, Michael Marceau, Roland Brosch, Franz-Christoph Bange, Philip Supply, Axel Magalon, Olivier Neyrolles
The unique ability of the tuberculosis (TB) bacillus, Mycobacterium tuberculosis, to persist for long periods of time in lung hypoxic lesions chiefly contributes to the global burden of latent TB. We and others previously reported that the M. tuberculosis ancestor underwent massive episodes of horizontal gene transfer (HGT), mostly from environmental species. Here, we sought to explore whether such ancient HGT played a part in M. tuberculosis evolution towards pathogenicity. We were interested by a HGT-acquired M...
November 27, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/29176633/epidemiology-and-predictors-of-ntm-pulmonary-infection-in-taiwan-a-retrospective-five-year-multicenter-study
#9
Hung-Ling Huang, Meng-Hsuan Cheng, Po-Liang Lu, Chin-Chung Shu, Jann-Yuan Wang, Jann-Tay Wang, Inn-Wen Chong, Li-Na Lee
Multicenter, longitudinal studies on nontuberculous mycobacteria (NTM) pulmonary infection (PI) are lacking. This study provides a 5-year epidemiological overview of NTM-PI in Taiwan and investigated its predictors. The clinical relevance of each respiratory NTM isolate in six hospitals between 2008 and 2014 was determined according to current guidelines. Recurrent episodes were judged by serial bacteriological results. New episodes of NTM-PI and pulmonary colonization (PC) occurring since 2010 were analyzed...
November 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29173447/clinical-characteristics-and-treatment-outcomes-of-pleural-effusions-in-patients-with-nontuberculous-mycobacterial-disease
#10
Sojung Park, Kyung-Wook Jo, Sang-Do Lee, Woo Sung Kim, Tae Sun Shim
BACKGROUND: The incidence of nontuberculous mycobacterial (NTM) infection has increased over the last 10 years. However, the clinical characteristics and treatment outcomes of patients with NTM pleuritis have not been well defined. METHODS: Patients with pleural effusion and NTM lung disease diagnosed between 1997 and 2013 were enrolled and their medical records were reviewed retrospectively. The subjects were divided into definite (n = 9, NTM isolated from the pleura or pleural effusion) and possible (n = 5, NTM lung disease with pleural effusion and improvement of effusion after anti-NTM treatment) groups...
December 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/29109708/differential-identification-of-mycobacterial-species-using-high-resolution-melting-analysis
#11
Azar D Khosravi, Mohammad Hashemzadeh, Abdolrazagh Hashemi Shahraki, Ali Teimoori
Infections caused by non-tuberculous mycobacteria (NTM) is increasing wordwide. Due to the difference in treatment of NTM infections and tuberculosis, rapid species identification of mycobacterial clinical isolates is necessary for the effective management of mycobacterial diseases treatment and their control strategy. In this study, a cost-effective technique, real-time PCR coupled with high-resolution melting (HRM) analysis, was developed for the differentiation of Mycobacterial species using a novel rpoBC sequence...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29097168/synthesis-and-biological-evolution-of-hydrazones-derived-from-4-trifluoromethyl-benzohydrazide
#12
Martin Krátký, Szilvia Bősze, Zsuzsa Baranyai, Jiřina Stolaříková, Jarmila Vinšová
Reflecting the known biological activity of isoniazid-based hydrazones, seventeen hydrazones of 4-(trifluoromethyl)benzohydrazide as their bioisosters were synthesized from various benzaldehydes and aliphatic ketones. The compounds were screened for their in vitro activity against Mycobacterium tuberculosis, nontuberculous mycobacteria (M. avium, M. kansasii), bacterial and fungal strains. The most antimicrobial potent derivatives were also investigated for their cytostatic and cytotoxic properties against three cell lines...
October 21, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29050776/blood-antimicrobial-activity-varies-against-different-mycobacterium-spp
#13
Octavio Miguel Rivero-Lezcano, Sara Blanco-Conde, Ramiro López-Medrano, Eduardo López-Fidalgo, Manuela Caño-Herrero, Teresa Nebreda-Mayoral
In vitro analysis of mycobacterial pathogenicity or host susceptibility has traditionally relied on the infection of macrophages, the target cell of mycobacteria, despite difficulties reproducing their antimycobacterial activity. We have employed alternative models, namely whole blood and leukocytes in plasma, from QuantiFERON negative individuals, and performed infections with the pathogenic M. tuberculosis, the less pathogenic M. avium, M. kansasii and M. chelonae and the occasionally pathogenic M. gordonae and M...
December 2017: Tuberculosis
https://www.readbyqxmd.com/read/28990320/non-tuberculosis-mycobacterium-speciation-using-hplc-under-revised-national-tb-control-programme-rntcp-in-india
#14
George Sebastian, Sharath Burugina Nagaraja, Telagi Vishwanatha, Mamatha Voderhobli, Narayana Vijayalakshmi, Prahlad Kumar
AIMS: Non-Tuberculous Mycobacteria (NTM) are ubiquitous in nature. The data on prevalence of NTM under the RNTCP is scarce. Many NTM species have clinical significance, and hence their identification and speciation are important. METHODS AND RESULT: It is a cross-sectional study conducted at the five RNTCP accredited culture and drug susceptibility testing (CDST) laboratory. The culture isolates from AFB positive but Immunochromatographic test negative samples were taken for identification and speciation using HPLC...
October 9, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28947034/treatment-and-outcome-of-non-tuberculous-mycobacterial-pulmonary-disease-in-a-predominantly-fibro-cavitary-disease-cohort
#15
Sanne Zweijpfenning, Stephan Kops, Cecile Magis-Escurra, Martin J Boeree, Jakko van Ingen, Wouter Hoefsloot
BACKGROUND: The incidence of non-tuberculous mycobacterial pulmonary disease (NTM-PD) has increased in the Netherlands. The fibro-cavitary disease manifestation predominates, as elsewhere in Europe. We studied treatment and outcome of this disease manifestation, as such data are scarce. METHODS: We conducted a retrospective study of all patients diagnosed with NTM-PD according to the American Thoracic Society statement between 2008 and 2013 in a reference clinic...
October 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28942306/systemic-mycobacterium-kansasii-infection-in-a-domestic-shorthair-cat
#16
S-H Lee, D-M Go, S-H Woo, H-T Park, E Kim, H S Yoo, D-Y Kim
A 1-year-old, female domestic shorthair cat was presented with anorexia, depression and weight loss, accompanied by multifocal nodules affecting the face, pinnae and periarticular tissue. Routine medical treatments were ineffective. The animal's physical condition continued to deteriorate and it finally died. Post-mortem examination revealed multifocal to coalescing firm nodules with occasional ulceration affecting the ears, peri-ocular areas, nasal planum, oral cavity and laryngopharyngeal region. Tan-coloured, firm, nodular lesions were also observed in the periarticular tissue, lungs and tracheobronchial and mediastinal lymph nodes...
August 2017: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/28940325/evaluation-of-the-rt-lamp-and-lamp-methods-for-detection-of-mycobacterium-tuberculosis
#17
Dandan Wu, Jiwen Kang, Baosheng Li, Dianxing Sun
BACKGROUND: The current methods for detecting Mycobacterium tuberculosis (Mtb) are not clinically optimal. Standard culture methods (SCMs) are slow, costly, or unreliable, and loop-mediated isothermal amplification (LAMP) cannot differentiate live Mtb. METHODS: This study compared reverse transcription (RT)-LAMP, LAMP, and an SCM for detecting Mtb. A first experiment tested the sensitivity and specificity of primers for 9 species of Mycobacterium (H37Rv, M. intracellulare, M...
September 22, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28931915/non-tuberculous-mycobacteria-isolated-from-pulmonary-samples-in-sub-saharan-africa-a-systematic-review-and-meta-analyses
#18
Catherine Okoi, Suzanne T B Anderson, Martin Antonio, Sarah N Mulwa, Florian Gehre, Ifedayo M O Adetifa
Pulmonary non-tuberculous mycobacterial (NTM) disease epidemiology in sub-Saharan Africa is not as well described as for pulmonary tuberculosis. Earlier reviews of global NTM epidemiology only included subject-level data from one sub-Saharan Africa country. We systematically reviewed the literature and searched PubMed, Embase, Popline, OVID and Africa Wide Information for articles on prevalence and clinical relevance of NTM detection in pulmonary samples in sub-Saharan Africa. We applied the American Thoracic Society/Infectious Disease Society of America criteria to differentiate between colonisation and disease...
September 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28925956/sulfadiazine-salicylaldehyde-based-schiff-bases-synthesis-antimicrobial-activity-and-cytotoxicity
#19
Martin Krátký, Magdaléna Dzurková, Jiří Janoušek, Klára Konečná, František Trejtnar, Jiřina Stolaříková, Jarmila Vinšová
The resistance among microbes has brought an urgent need for new drugs. Thus, we synthesized a series of Schiff bases derived from the sulfa drug sulfadiazine and various salicylaldehydes. The resulting 4-[(2-hydroxybenzylidene)amino]-N-(pyrimidin-2-yl)benzene-sulfonamides were characterized and evaluated against Gram-positive and Gram-negative bacteria, yeasts, moulds, Mycobacterium tuberculosis, nontuberculous mycobacteria (M. kansasii, M. avium) and their cytotoxicity was determined. Among bacteria, the genus Staphylococcus, including methicillin-resistant S...
September 19, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28923675/respiratory-infections-due-to-nontuberculous-mycobacterias
#20
REVIEW
Luis Máiz Carro, Esther Barbero Herranz, Rosa Nieto Royo
The most common infections caused by nontuberculous mycobacteria (NTM) are lung infections. The microorganisms causing these infections most frequently are Mycobacterium avium complex, Mycobacterium kansasii and Mycobacterium abscessus complex. Their incidence has increased in the last three decades. After identifying an NTM in the respiratory tract, clinical and radiological aspects must be considered to determine if isolations are clinically relevant. Predisposing conditions that could contribute to infection must also be investigated...
September 15, 2017: Medicina Clínica
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