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https://www.readbyqxmd.com/read/29594145/exit-site-infection-due-to-mycobacterium-chelonae-in-an-elderly-patient-on-peritoneal-dialysis
#1
Arata Hibi, Takahisa Kasugai, Keisuke Kamiya, Chiharu Ito, Satoru Kominato, Toshiyuki Miura, Katsushi Koyama
Nontuberculous mycobacteria (NTM) are rarely isolated from peritoneal dialysis (PD)-associated catheter infections. However, NTM infection is usually difficult to treat and leads to catheter loss. Prompt diagnosis is essential for appropriate treatment. A 70-year-old Japanese man who had been on PD for 2 years and with a medical history of 2 episodes of exit site infections (ESIs) due to methicillin-resistant Staphylococcus aureus was admitted to the hospital due to suspected ESI recurrence. However, Gram staining of the pus revealed no gram-positive cocci...
January 2018: Case Reports in Nephrology and Dialysis
https://www.readbyqxmd.com/read/29563276/non-tuberculous-mycobacterial-infections-related-to-peritoneal-dialysis
#2
Hiroyuki Inoue, Naoki Washida, Kohkichi Morimoto, Keisuke Shinozuka, Takahiro Kasai, Kiyotaka Uchiyama, Hirobumi Tokuyama, Shu Wakino, Hiroshi Itoh
Most infections related to peritoneal dialysis (PD) are caused by common bacteria, and non-tuberculous mycobacteria are rare. The clinical characteristics and prognosis of PD patients with non-tuberculous mycobacterial infections were investigated at our hospital. Non-tuberculous mycobacteria were detected in 11 patients (exit-site infection, tunnel infection, and peritonitis in 3, 5, and 3 patients, respectively). Mycobacterium fortuitum , Mycobacterium chelonae , and Mycobacterium abscessus were identified in 4, 2, and 2 patients, respectively...
March 2018: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/29516897/-mycobacterium-chelonae-osteomyelitis-presenting-as-a-mycobacterial-spindle-cell-pseudotumor
#3
Victoria Thwaites, Julia Colston, Jose Lomas-Cabeza, Zsolt Orosz
We report a case of an 88-year-old man with osteomyelitis of the right ankle, with histopathology demonstrating a Mycobacterium spindle cell pseudotumor. The Mycobacterium contained in this spindle cell pseudotumor was Mycobacterium chelonae. M. chelonae spindle cell pseudotumors are rare and have only been reported twice previously in the literature. Similarly, M. chelonae presenting as the pathogen in bone infection is rare. Due to this unusual presentation of M. chelonae, the antibiotic rationale was based largely on case reports and consisted of imipenem, clarithromycin, and linezolid...
January 2018: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/29497402/phylogenomics-and-comparative-genomic-studies-robustly-support-division-of-the-genus-mycobacterium-into-an-emended-genus-mycobacterium-and-four-novel-genera
#4
Radhey S Gupta, Brian Lo, Jeen Son
The genus Mycobacterium contains 188 species including several major human pathogens as well as numerous other environmental species. We report here comprehensive phylogenomics and comparative genomic analyses on 150 genomes of Mycobacterium species to understand their interrelationships. Phylogenetic trees were constructed for the 150 species based on 1941 core proteins for the genus Mycobacterium , 136 core proteins for the phylum Actinobacteria and 8 other conserved proteins. Additionally, the overall genome similarity amongst the Mycobacterium species was determined based on average amino acid identity of the conserved protein families...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29476412/clinical-features-of-infection-caused-by-non-tuberculous-mycobacteria-7-years-experience
#5
Tatjana Adzic-Vukicevic, Aleksandra Barac, Ana Blanka-Protic, Marija Laban-Lazovic, Bojana Lukovic, Vesna Skodric-Trifunovic, Salvatore Rubino
INTRODUCTION: Non-tuberculous mycobacteria (NTM) are ubiquitous organisms associated with various infections. The aim of the study was to determine the most relevant clinical characteristics of NTM during the 7-year period. METHODOLOGY: A retrospective study of NTM infections was conducted between January 2009 and December 2016. The American Thoracic Society/Infectious Disease Society of America criteria were used to define cases of pulmonary or an extrapulmonary site...
February 23, 2018: Infection
https://www.readbyqxmd.com/read/29472421/-mycobacterium-chelonae-developing-multidrug-resistance
#6
Vinod Kumar Mannelli, Manoj P Rai, Divyesh Reddy Nemakayala, Naga Preethi Kadiri
Mycobacterium chelonae is a rapidly growing mycobacterium which is known to respond well to standard antibiotic treatment regimen. There are no specific guidelines for treatment. Antibiotics are chosen based on the bacterial sensitivity. Here we present a 47-year-old man with hip replacement who developed bright red papular generalised skin lesions and bilateral hip abscess. On workup, it was confirmed that M. chelonae was the causative organism. He was given 8 weeks of antibiotics; however, there was worsening of the hip abscess on interval imaging...
February 22, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29469779/cutaneous-infection-due-to-mycobacterium-immunogenum-an-european-case-report-and-review-of-the-literature
#7
Elena Garcia-Zamora, Henar Sanz-Robles, Marta Elosua-Gonzalez, Ximena Rodriguez-Vasquez, Jose Luis Lopez-Estebaranz
(no more than 200 words): In the last few years, the incidence of cutaneous infections caused by nontuberculous mycobacteria is increasing. Since Mycobacterium immunogenum was first described in 2001, few case reports have been described, all of them in the American continent. We report a case with cutaneous infection caused by this newly discovered NTB in Europe.A 65-year-old woman presented with a 3-months history of pruritic lesions on abdomen. Examination revealed erythematous inflammatory papules, pustules, and crusts...
October 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29400108/nontuberculous-mycobacterium-infection-in-renal-transplant-recipients-a-systematic-review
#8
Yan Song, Li Zhang, Hao Yang, Guangjun Liu, Hongfeng Huang, Jianyong Wu, Jianghua Chen
BACKGROUND: Nontuberculous mycobacterium (NTM) infections are important complications in renal transplant recipients. METHODS: Cases of NTM diseases post-renal transplantation published in English were identified in the PubMed database. The clinical and laboratory characteristics of these cases were reviewed. RESULTS: One-hundred and fifteen cases of NTM infection in renal transplant recipients in 100 articles were identified. The median time of NTM infection from renal transplantation was 37 months (range, 3 d to 252 months)...
February 5, 2018: Infectious Diseases
https://www.readbyqxmd.com/read/29369747/survival-of-bacterial-and-parasitic-pathogens-from-zebrafish-danio-rerio-after-cryopreservation-and-thawing
#9
Lauren J Norris, Virginia Watral, Michael L Kent
Cryopreservation is a common method used to preserve the sperm of various animal species, and it is widely used with zebrafish (Danio rerio). As with other animals, there is a possibility of paternal pathogen transmission through sperm. We evaluated the ability of five common and important pathogens of zebrafish to survive cryopreservation as used with zebrafish sperm and freezing without cryopreservant. We evaluated Mycobacterium chelonae, Mycobacterium marinum, and Edwardsiella ictaluri, each originally isolated from zebrafish, eggs of Pseuodocapillaria tomentosa, and spores of Pseudoloma neurophilia...
April 2018: Zebrafish
https://www.readbyqxmd.com/read/29368988/activities-of-dual-combinations-of-antibiotics-against-multidrug-resistant-nontuberculous-mycobacteria-recovered-from-patients-with-cystic-fibrosis
#10
Matthew Schwartz, Stefanie Fisher, Elizabeth Story-Roller, Gyanu Lamichhane, Nicole Parrish
Patients with cystic fibrosis (CF) are at risk for recurrent pulmonary infections due to increased viscosity of airway secretions, leading to persistent colonization with pathogenic bacteria, including nontuberculous mycobacteria (NTM). Extensive antibiotic use for treatment of infections has led to increasing antimicrobial resistance, which is a significant barrier to the treatment of NTMs. We examined the in vitro activity of several antibiotics against a selection of the most drug-resistant clinical isolates of Mycobacterium abscessus, Mycobacterium chelonae, and Mycobacterium avium complex recovered from CF patients at our institution, as well as paired combinations of antibiotics against a subset of M...
January 25, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29359872/mycobacterium-abscessus-infections-in-lung-transplant-recipients-15-year-experience-from-a-single-institution
#11
Morsal Osmani, David Sotello, Salvador Alvarez, John A Odell, Mathew Thomas
PURPOSE: To evaluate our institutional experience with Mycobacterium abscessus infections occurring in lung transplant recipients (LTR). METHODS: We retrospectively reviewed our prospectively collected institutional adult lung transplant database from 2001 to 2015 to identify patients with M. abscessus or Mycobacterium chelonae/abscessus infection before or after transplantation. Untreated, colonized patients were excluded from the study. Electronic health records of nine out of 516 lung recipients (1...
April 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29332650/amplification-of-hsp-65-gene-and-usage-of-restriction-endonuclease-for-identification-of-non-tuberculous-rapid-grower-mycobacterium
#12
Ajoy Kumar Verma, Rohit Sarin, Vijay Kumar Arora, Gavish Kumar, Jyoti Arora, Paras Singh, Vithal Prasad Myneedu
BACKGROUND: The rapid grower mycobacteria have emerged as significant group of human pathogen amongst the Runyon group IV organisms that are capable of causing infection in both the healthy and immunocompromised hosts. Study aimed to identification of species amongst rapid grower non tuberculous mycobacterial isolates by polymerase chain reaction - restriction enzyme analysis (PRA). Analysis and comparison of results with standard biochemical tests. METHODS: Rapid grower non tuberculous mycobacteria had been collected from liquid culture section during the study period...
January 2018: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/29318359/response-to-comment-on-mycobacterium-chelonae-infection-of-the-buttocks-secondary-to-lipofilling-a-case-report-and-review-of-the-literature
#13
S E Hammond, J A Jaller, N Joumblat, R S Kirsner, C J Salgado
No abstract text is available yet for this article.
April 2018: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29314762/opportunistic-infections-in-patients-with-idiopathic-inflammatory-myopathies
#14
Ada Redondo-Benito, Adrian Curran, Ana Villar-Gomez, Ernesto Trallero-Araguas, Andreu Fernández-Codina, Iago Pinal-Fernandez, Jose Ángel Rodrigo-Pendás, Albert Selva-O'Callaghan
AIM: To describe the prevalence, clinical characteristics and risk factors of opportunistic infection (OI) in a cohort of patients with inflammatory myopathies, and compare mortality rates between those with and without OIs. METHODS: In total, 204 patients from our myositis cohort were reviewed to identify patients who had experienced an OI during the period 1986-2014. The patients' clinical characteristics, treatments received, and outcomes were systematically recorded...
February 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29286459/environmental-screening-of-aeromonas-hydrophila-mycobacterium-spp-and-pseudocapillaria-tomentosa-in-zebrafish-systems
#15
Jean-Philippe Mocho, Darren J Martin, Mollie E Millington, Yolanda Saavedra Torres
Health monitoring systems are developed and used in zebrafish research facilities because pathogens of Danio rerio such as Aeromonas hydrophila, Mycobacterium spp., and Pseudocapillaria tomentosa have the potential to impair animal welfare and research. The fish are typically analyzed post mortem to detect microbes. The use of sentinels is a suggested way to improve the sensitivity of the surveillance and to reduce the number of animals to sample. The setting of a pre-filtration sentinel tank out of a recirculating system is described...
December 8, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29241819/cyclophostin-and-cyclipostins-analogues-new-promising-molecules-to-treat-mycobacterial-related-diseases
#16
Phuong Chi Nguyen, Abdeldjalil Madani, Pierre Santucci, Benjamin P Martin, Rishi R Paudel, Sandrine Delattre, Jean-Louis Herrmann, Christopher D Spilling, Laurent Kremer, Stéphane Canaan, Jean-François Cavalier
The progression of mycobacterial diseases requires the development of new therapeutics. This study evaluated the efficacy and selectivity of a panel of Cyclophostin and Cyclipostins analogues (CyCs) against various bacteria and mycobacteria. The activity 26 CyCs was first assayed by the agar plate method. Compounds exhibiting 50-100% growth inhibition were then selected to determine their minimum inhibitory concentrations (MICs) by the resazurin microtiter assay (REMA). The best drug candidate was further tested against clinical mycobacterial isolates and bacteria responsible for nosocomial infections, including 6 Gram-negative bacteria, 5 Gram-positive bacteria, 29 rapid-growing mycobacteria belonging to the Mycobacterium chelonae-abscessus clade and 3 slow-growing mycobacteria (Mycobacterium marinum, Mycobacterium bovis BCG and Mycobacterium tuberculosis)...
December 11, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29236773/first-insights-into-a-type-ii-toxin-antitoxin-system-from-the-clinical-isolate-mycobacterium-sp-mhsd3-similar-to-epsilon-zeta-systems
#17
Daniel Jaén-Luchoro, Francisco Aliaga-Lozano, Rosa Maria Gomila, Margarita Gomila, Francisco Salvà-Serra, Jorge Lalucat, Antoni Bennasar-Figueras
A putative type II toxin-antitoxin (TA) system was found in the clinical isolate Mycobacterium sp. MHSD3, a strain closely related to Mycobacterium chelonae. Further analyses of the protein sequences of the two genes revealed the presence of domains related to a TA system. BLAST analyses indicated the presence of closely related proteins in the genomes of other recently published M. chelonae strains. The functionality of both elements of the TA system was demonstrated when expressed in Escherichia coli cells, and the predicted structure of the toxin is very similar to those of well-known zeta-toxins, leading to the definition of a type II TA system similar to epsilon/zeta TA systems in strains that are closely related to M...
2017: PloS One
https://www.readbyqxmd.com/read/29234549/bilateral-mycobacterium-chelonae-keratitis-after-phacoemulsification-cataract-surgery
#18
Jaime D Martinez, Guillermo Amescua, Jesus Lozano-Cárdenas, Leejee H Suh
The purpose of this manuscript is to report the case of an 81-year-old patient who presented with bilateral keratitis after phacoemulsification surgery. Cultures came back positive for Mycobacterium chelonae . Despite aggressive topical and systemic antimicrobial treatment, the patient developed a corneal perforation in both eyes, treated with corneal glue in the right eye and corneoscleral patch in the left eye. After two years of follow-up, patient was free of infection in the right eye with visual acuity of 20/200 and the left eye progressed to phthisis bulbi...
2017: Case Reports in Ophthalmological Medicine
https://www.readbyqxmd.com/read/29207758/-mycobacterium-fortuitum-infection-at-umbilical-hernioplasty-site
#19
Bharti Chogtu, Daliparty Vasudev Malik, Rahul Magazine, Vishnu Prasad Shenoy
Non Tuberculous Mycobacteria (NTM) are a group of rapidly growing mycobacteria and are generally considered to be of low virulence. Of late, there has been an increase in incidence of infections due to these organisms. Among them, Mycobacterium fortuitum, M. chelonae and M. abscessus are the common species which have been identified. Though they are occasionally implicated in pulmonary infections, NTM are very commonly associated with cutaneous infections, especially surgical site infections. Identification of NTM infection at such sites should be suspected when there is delayed healing of the wound...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29121135/sporotrichoid-pattern-of-mycobacterium-chelonae-abscessus-infection
#20
Jessica L Boulavsky, Holly M Wright, Paul M Rodriguez-Waitkus, Andrew R DiNardo, Laila E Woc-Colburn, Harry Dao
No abstract text is available yet for this article.
September 2017: Cutis; Cutaneous Medicine for the Practitioner
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