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https://www.readbyqxmd.com/read/27900974/disseminated-mycobacteria-chelonae-infection-in-a-kidney-pancreas-transplant-recipient-a-case-report-and-review-of-the-literature
#1
Shafi Malik, Ananda Ghosh, Shahid Husain
A 40-year-old male with a long-standing history of type 1 diabetes with end-stage renal failure underwent combined kidney-pancreas (KP) transplant from a standard criteria donor. Post-operative course was uncomplicated with good primary function of both transplant grafts. Induction was with thymoglobulin and maintenance immunosuppression was with tacrolimus, mycophenolate mofetil and prednisolone. Nine weeks post-transplant, the patient developed dysfunction of both grafts. Panel reactive antibody testing revealed that the patient had developed a de novo donor-specific antibody and considering an antibody-mediated rejection the patient was treated with intravenous pulse methyl prednisone 500 mg ×3 doses, IV immunoglobulin 2 mg/kg in two divided doses, and ATG 7 mg/kg (total dose of 700 mg)...
November 2016: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/27887611/the-performance-of-interferon-gamma-release-assay-in-nontuberculous-mycobacterial-diseases-a-retrospective-study-in-china
#2
Mao-Shui Wang, Jun-Li Wang, Xin-Feng Wang
BACKGROUND: The interferon-gamma release assay (IGRA) is more specific than the tuberculin skin test to discriminate between tuberculosis (TB) and nontuberculous mycobacterial (NTM) diseases. Here we performed a retrospective study to evaluate the performance of the T-SPOT.TB in patients with NTM diseases. METHODS: Between March, 2013 and Nov, 2015, a total of 58 patients with NTM diseases had a T-SPOT.TB performed were enrolled, 30 patients had definite NTM diseases, 28 had probable diseases...
November 25, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27847012/prevalence-and-species-spectrum-of-both-pulmonary-and-extrapulmonary-nontuberculous-mycobacteria-isolates-at-a-tertiary-care-center
#3
Jyoti Umrao, Dharamveer Singh, Amreen Zia, Swati Saxena, Surendra Sarsaiya, Shushma Singh, Jahanarah Khatoon, Tapan N Dhole
OBJECTIVE/BACKGROUND: Nontuberculous mycobacteria (NTM) infection associated with pulmonary and extrapulmonary disease has been increasing globally. Despite an increase in incidence rate of NTM infection, its prevalence, species diversity, and circulation pattern in India is largely unknown. This study sought to investigate the overall burden and diversity of NTM among both pulmonary and extrapulmonary clinical isolates from a Northern Indian population. METHODS: The study was conducted in the Department of Microbiology, from January 2013 to December 2015...
September 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/27843236/mycobacterium-chelonae-in-a-tectonic-corneal-graft
#4
Haziq Raees Chowdhury, Oliver Comyn, Gill Jones, Mayank A Nanavaty
Atypical mycobacterial infections of the cornea can present with nonspecific inflammatory changes and graft rejection, with no obvious focus to culture and a subsequent delay to diagnosis. These pathogens are well documented in the literature following laser-assisted in situ keratomileusis but have rarely been described following corneal transplant surgery. We report a single case of Mycobacterium chelonae keratitis 1 year after tectonic keratoplasty.
September 2016: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/27789202/use-of-green-fluorescent-protein-labeled-non-tuberculous-mycobacteria-to-evaluate-the-activity-quaternary-ammonium-compound-disinfectants-and-antibiotics
#5
Claudia Cortesia, Teresita Bello, Gustavo Lopez, Scott Franzblau, Jacobus de Waard, Howard Takiff
Although infections with NonTuberculous Mycobacteria have become less common in AIDS patients, they are important opportunistic infections after surgical procedures, likely because they are ubiquitous and not efficiently killed by many commonly used disinfectants. In Venezuela there have recently been many non-tuberculous mycobacteria soft tissue infections after minor surgical procedures, some apparently related to the use of a commercial disinfectant based on a Quaternary Ammonium Compound. We studied the activity of this and other quaternary ammonium compounds on different non-tuberculous mycobacteria by transforming the mycobacteria with a dnaA-gfp fusion and then monitoring fluorescence to gauge the capacity of different quaternary ammonium compounds to inhibit bacterial growth...
October 11, 2016: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/27782812/real-time-pcr-for-the-rapid-identification-and-drug-susceptibility-of-mycobacteria-present-in-bronchial-washings
#6
Thilini Piushani Keerthirathne, Dhammika Nayoma Magana-Arachchi, Dushantha Madegedara, Suneth Sithumini Sooriyapathirana
BACKGROUND: Mycobacteria have a spectrum of virulence and different susceptibilities to antibiotics. Distinguishing mycobacterial species is vital as patients with non-tuberculous mycobacterial (NTM) infections present clinical features that are similar to those of patients with tuberculosis. Thus, rapid differentiation of Mycobacterium tuberculosis complex from NTM is critical to administer appropriate treatment. Hence the aim of the study was to rapid identification of mycobacterial species present in bronchial washings using multiplex real time Polymerase Chain Reaction (PCR) and to determine the drug susceptibility in identified mycobacterial species...
October 26, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27777254/mycobacterium-chelonae-bacteremia-in-a-patient-taking-infliximab-and-prednisone
#7
Caitlin McCallum, Bijai Johnson
No abstract text is available yet for this article.
October 24, 2016: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/27747884/mycobacteria-in-aquarium-fish-results-of-a-3-year-survey-indicate-caution-required-in-handling-pet-shop-fish
#8
D Kušar, U Zajc, V Jenčič, M Ocepek, J Higgins, M Žolnir-Dovč, M Pate
Fish are commonly infected with non-tuberculous mycobacteria (NTM), which should be regarded as potential pathogens when handling aquarium fish and equipment. This study examined 107 aquarium fish from pet shops. Cultivation of the fish samples using different selective media was conducted for identification of NTM. Isolates were identified using the GenoType Mycobacterium common mycobacteria and additional species assays, sequencing of the 16S rRNA and rpoB genes, and real-time PCR assay for identification of Mycobacterium (M...
October 17, 2016: Journal of Fish Diseases
https://www.readbyqxmd.com/read/27679721/cutaneous-mycobacterium-chelonae-infection-distal-to-the-arteriovenous-fistula
#9
Charlotte Van Ende, Dunja Wilmes, Frédéric E Lecouvet, Laura Labriola, René Cuvelier, Grégory Van Ingelgem, Michel Jadoul
A few single cases of Mycobacterium chelonae skin infection have been reported in haemodialysis patients. We report three additional cases that share peculiar clinical characteristics, pointing to diagnostic clues. All three cases presented as erythematous nodules developing distally to a proximal arteriovenous fistula (AVF). This presentation was identical to that of two published cases. A survey of all Belgian haemodialysis units during the period 2007-11 yields an estimated incidence of ∼0.9/10 000 patient-years...
October 2016: Clinical Kidney Journal
https://www.readbyqxmd.com/read/27668545/verification-of-frequency-in-species-of-nontuberculous-mycobacteria-in-kermanshah-drinking-water-supplies-using-the-pcr-sequencing-method
#10
Parviz Mohajeri, Laya Yazdani, Abdolrazagh Hashemi Shahraki, Amirhoshang Alvandi, Sara Atashi, Abbas Farahani, Ali Almasi, Mansour Rezaei
BACKGROUND: Nontuberculous mycobacteria are habitants of environment, especially in aquatic systems. Some of them cause problems in immunodeficient patients. Over the last decade, 16S rRNA gene sequencing was established in 45 novel species of nontuberculous mycobacteria. Experiences revealed that this method underestimates the diversity, but does not distinguish between some of mycobacterium subsp. To recognize emerging rapidly growing mycobacteria and identify their subsp, rpoB gene sequencing has been developed...
September 26, 2016: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/27575460/a-rapid-standardized-protein-extraction-method-using-adaptive-focused-acoustics-for-identification-of-mycobacteria-by-maldi-tof-ms
#11
La'Tonzia L Adams, Kim Dionne, Stephanie Fisher, Nicole Parrish
Mycobacterial identification using MALDI-ToF MS (MALDI) has been hindered by inadequate extraction methods. Adaptive Focused Acoustics™ uses concentrated ultrasonic energy to achieve cellular disruption. Using this technology, we developed a rapid mycobacterial inactivation/protein extraction method for MALDI-based identification. Agreement for identification to the species level versus conventional identification was stratified by log confidence cut-offs of ≥2.0, ≥ 1.8, or ≥1.7. A total of 182 mycobacterial isolates were tested...
November 2016: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/27533773/management-of-mycobacterium-chelonae-endophthalmitis-with-complete-surgical-debridement
#12
Andrew J Barkmeier, Diva M Salomao, Keith H Baratz
PURPOSE: To report the clinical course and histopathologic findings of two consecutive patients with resolution of Mycobacterium chelonae endophthalmitis and favorable visual outcomes after complete removal of intraocular implants and lens capsular complexes and prolonged sensitivity-guided combination antibiotic therapy. METHODS: Medical records and histopathologic findings were reviewed for two consecutive patients with M. chelonae endophthalmitis. RESULTS: Two consecutive patients with M...
December 2016: Retina
https://www.readbyqxmd.com/read/27467288/mycobacterium-chelonae-sinusitis-in-an-immunocompetent-adult
#13
Melanie D Hicks, Peter S Karempelis, Seth C Janus
No abstract text is available yet for this article.
August 1, 2016: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/27453998/investigation-and-management-of-an-outbreak-of-multispecies-mycobacteriosis-in-australian-lungfish-neoceratodus-fosteri-including-the-use-of-triple-antibiotic-treatment
#14
T B Strike, Y Feltrer, E Flach, S K Macgregor, S Guillaume
Disease due to non-tuberculous mycobacteria (NTM) is common in fish. Current recommendations focus on outbreak management by depopulating entire fish stocks and disinfecting tanks. Treatment is not advocated. Treatment may be appropriate, however, where individual, valuable fish are concerned. ZSL London Zoo managed an outbreak of mycobacteriosis in a valuable group of imported F1 captive-bred Australian lungfish (Neoceratodus fosteri) by depopulation, isolation, extensive testing and daily oral antibiotic treatment...
July 25, 2016: Journal of Fish Diseases
https://www.readbyqxmd.com/read/27451824/multiple-lumps-in-the-breast-due-to-mycobacterium-fortuitum
#15
Shirish S Chandanwale, Ishita Gulati, Dadaso S Baravkar, Sumedha P Shinde, Neha Mishra
Although breast tissue is the most resistant to tuberculosis, its incidence is increasing worldwide. High incidence of breast tuberculosis is presumed in India. The rapidly growing nontubercular mycobacteria, such as Mycobacterium fortuitum and Mycobacterium chelonae, are of increasing clinical importance because infections due to these organisms are often hospital acquired. The true incidence of M. fortuitum is unknown but it has been estimated to be between 4 and 6 cases per one million people. It causes skin or soft tissue infections following trauma or surgery...
April 2016: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/27451822/drug-susceptibility-testing-of-rapidly-growing-mycobacteria-in-extrapulmonary-tuberculosis
#16
Geeta V Gole, Reena Set, Nishat Khan, Jayanthi Shastri
There has been an increasing awareness of the rapidly growing mycobacteria (RGM), of which numerous species and phylogenetic groups are clearly established human pathogens. It is important to appropriately distinguish RGM from other mycobacteria, as first-line antituberculous drugs are ineffective for their treatment. Variability in susceptibility of RGM is seen in relation to species, different geographical areas, and time. Therefore, we conducted a study to speciate the isolates of RGM and perform antimicrobial susceptibility testing...
April 2016: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/27439781/clinical-and-microbiological-profile-of-non-tuberculous-mycobacterial-endophthalmitis-experience-in-a-tertiary-eye-care-centre-in-southern-india
#17
Remya Mareen Paulose, Joveeta Joseph, Raja Narayanan, Savitri Sharma
BACKGROUND: Endophthalmitis caused by non-tuberculous mycobacteria (NTM) is a rare condition seen after surgery and trauma. This study reports a retrospective, consecutive, non-comparative case series of 5 patients referred to L. V. Prasad Eye Institute, Hyderabad, and diagnosed with culture-proven NTM endophthalmitis between January 2004 and April 2015. Data collected included demographic information, presenting features, microbiology investigation, treatment course, and final visual outcome...
December 2016: Journal of Ophthalmic Inflammation and Infection
https://www.readbyqxmd.com/read/27415637/necrotizing-thrombophlebitis-secondary-to-mycobacterium-chelonae-in-a-hemodialyzed-patient
#18
Lidia Maroñas-Jiménez, Sara Burillo-Martínez, Enrique Morales, Maria Concepción Garrido-Ruiz, Jose Luis Rodríguez-Peralto
No abstract text is available yet for this article.
July 12, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27374696/olecranon-osteomyelitis-caused-by-mycobacterium-chelonae
#19
Hideharu Hagiya, Misa Hayashi, Ichiro Katayama, Kazunori Tomono
No abstract text is available yet for this article.
2016: Internal Medicine
https://www.readbyqxmd.com/read/27368989/analysis-of-pulmonary-non-tuberculous-mycobacterial-infections-after-lung-transplantation
#20
S K Shah, K J McAnally, L Seoane, G A Lombard, S G LaPlace, S Lick, G S Dhillon, V G Valentine
PURPOSE: Non-tuberculous mycobacteria (NTM) are important pathogens in lung transplant recipients. This study describes the spectrum of NTM respiratory tract infections and examines the association of NTM infections with lung transplant complications. METHODS: Data from 208 recipients transplanted from November 1990 to November 2005 were analyzed. Follow-up data were available to November 2010. Lung infection was defined by bronchoalveolar lavage, sputum, or blood cultures in the appropriate clinical setting...
August 2016: Transplant Infectious Disease: An Official Journal of the Transplantation Society
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