Aristine Cheng, Anuj Kashyap, Helene Salvator, Lindsey B Rosen, Devon Colby, Fatemeh Ardeshir-Larijani, Patrick J Loehrer, Li Ding, Saul O Lugo Reyes, Sean Riminton, Madison Ballman, Joseph M Rocco, Beatriz E Marciano, Alexandra F Freeman, Sarah K Browne, Amy P Hsu, Adrian Zelazny, Arun Rajan, Irini Sereti, Christa S Zerbe, Michail S Lionakis, Steven M Holland
BACKGROUND: Autoantibodies against interleukin-12 (anti-interleukin-12) are often identified in patients with thymoma, but opportunistic infections develop in only some of these patients. Interleukin-12 (with subunits p40 and p35) shares a common subunit with interleukin-23 (subunits p40 and p19). In a patient with disseminated Burkholderia gladioli infection, the identification of both anti-interleukin-23 and anti-interleukin-12 prompted further investigation. METHODS: Among the patients (most of whom had thymoma) who were known to have anti-interleukin-12, we screened for autoantibodies against interleukin-23 (anti-interleukin-23)...
March 21, 2024: New England Journal of Medicine