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https://www.readbyqxmd.com/read/29167222/capsule-endoscopy-in-the-diagnosis-of-disseminated-mycobacterium-avium-complex-infection
#1
Ana Margarida Vaz, Francisco Velasco, Antonio Jesus Cadilla, Horácio Guerreiro
No abstract text is available yet for this article.
November 21, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29164915/establishment-of-a-bordetella-avium-challenge-model-in-turkeys
#2
Rebecca Knab, Henning Petersen, Silke Rautenschlein, Arne Jung
Despite the importance of Bordetella avium (BA) as a respiratory pathogen of young turkeys, no infection model for the evaluation of BA-vaccine efficacy is available. The objective of this study was to evaluate the influence of route and dose of infection on the establishment of a BA-challenge model. In our first experiment, 28-day-old turkeys were either inoculated oculonasally with 10(5), 10(7) or 10(9) colony forming units (CFU) of BA per animal or exposed to BA by aerosol with 10(5)-10(8) CFU/m(3). The respiratory tract of all inoculated animals was BA-colonised, which was confirmed by choanal swabs and samples of trachea and lung, showing the highest prevalence in the aerosol inoculated group...
November 22, 2017: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/29164156/disseminated-mycobacterium-avium-intracellulare-complex-infection-presenting-with-disseminated-intravascular-coagulation-in-an-aids-patient
#3
Folusakin Ayoade, James Cotelingam, Andrew Stevenson Joel Chandranesan
Disseminated Mycobacterium avium-intracellulare complex (MAC) infection is one of the relatively common opportunistic infections seen in severely immunocompromised AIDS patients. A constellation of clinical, laboratory, and pathological features involving multiple organ systems are often present in disseminated MAC infection but disseminated intravascular coagulation (DIC) has not been previously described in association with this condition. To our knowledge, this is the first reported case of DIC complicating disseminated MAC infection in an AIDS patient...
October 2017: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/29164142/pathogenesis-molecular-genetics-and-genomics-of-mycobacterium-avium-subsp-paratuberculosis-the-etiologic-agent-of-johne-s-disease
#4
REVIEW
Govardhan Rathnaiah, Denise K Zinniel, John P Bannantine, Judith R Stabel, Yrjö T Gröhn, Michael T Collins, Raúl G Barletta
Mycobacterium avium subsp. paratuberculosis (MAP) is the etiologic agent of Johne's disease in ruminants causing chronic diarrhea, malnutrition, and muscular wasting. Neonates and young animals are infected primarily by the fecal-oral route. MAP attaches to, translocates via the intestinal mucosa, and is phagocytosed by macrophages. The ensuing host cellular immune response leads to granulomatous enteritis characterized by a thick and corrugated intestinal wall. We review various tissue culture systems, ileal loops, and mice, goats, and cattle used to study MAP pathogenesis...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29162355/-hot-tub-lung-a-case-report
#5
M Vergez, S Honjoya, S Guérin, C Delacourt, G Benoist
Hot tub lung is a type of hypersensitivity pneumonitis caused by inhalational exposure to the Mycobacterium avium complex. We report the case of a 14-year-old boy presenting dyspnea with hypoxemia, whose medical history and clinical course helped make the diagnosis. Infectious causes were considered first, and antibiotics were initiated without success. Further questioning and explorations led to discussing a hypersensitivity pneumonitis diagnosis. Relapse after exposure to a hot tub enabled us to confirm hot tub lung...
November 18, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/29161575/sulfadiazine-ciprofloxacin-promote-opportunistic-pathogens-occurrence-in-bulk-water-of-drinking-water-distribution-systems
#6
Haibo Wang, Yi Shen, Chun Hu, Xueci Xing, Dan Zhao
Effects of sulfadiazine and ciprofloxacin on the occurrence of free-living and particle-associated opportunistic pathogens in bulk water of simulated drinking water distribution systems (DWDSs) were investigated. It was found that sulfadiazine and ciprofloxacin greatly promoted the occurrence of opportunistic pathogens including Pseudomonas aeruginosa, Legionella pneumophila, Mycobacterium avium and its broader genus Mycobacterium spp., as well as the amoebae Acanthamoeba spp. and Hartmanella vermiformis, in bulk water of DWDSs...
November 18, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29157379/incidence-of-fecal-excretion-of-mycobacterium-avium-subsp-paratuberculosis-in-dairy-cows-before-and-after-the-enrolment-in-the-qu%C3%A3-bec-voluntary-program
#7
J C Arango-Sabogal, J Paré, O Labrecque, G Côté, J P Roy, S Buczinski, V Wellemans, G Fecteau
Paratuberculosis is a chronic and contagious enteric disease of ruminants caused by Mycobacterium avium subsp. paratuberculosis (MAP). This disease of worldwide distribution is responsible for significant economic losses and the bacteria itself has been linked to human Crohn's disease. Paratuberculosis control programs focus on reducing MAP transmission by implementing better management practices that target infection routes. In Québec, a Voluntary Paratuberculosis Prevention and Control Program (QVPPCP) was launched in 2007...
December 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/29142508/proteomic-characterisation-of-bovine-and-avian-purified-protein-derivatives-and-identification-of-specific-antigens-for-serodiagnosis-of-bovine-tuberculosis
#8
José Antonio Infantes-Lorenzo, Inmaculada Moreno, María de Los Ángeles Risalde, Álvaro Roy, Margarita Villar, Beatriz Romero, Nieves Ibarrola, José de la Fuente, Eugenia Puentes, Lucía de Juan, Christian Gortázar, Javier Bezos, Lucas Domínguez, Mercedes Domínguez
Background: Bovine purified protein derivative (bPPD) and avian purified protein derivative (aPPD) are widely used for bovine tuberculosis diagnosis. However, little is known about their qualitative and quantitative characteristics, which makes their standardisation difficult. In addition, bPPD can give false-positive tuberculosis results because of sequence homology between Mycobacterium bovis (M. bovis) and M. avium proteins. Thus, the objective of this study was to carry out a proteomic characterisation of bPPD, aPPD and an immunopurified subcomplex from bPPD called P22 in order to identify proteins contributing to cross-reactivity among these three products in tuberculosis diagnosis...
2017: Clinical Proteomics
https://www.readbyqxmd.com/read/29140686/the-regulatory-mechanism-of-mycobacterium-tuberculosis-phosphoserine-phosphatase-serb2
#9
Gregory A Grant
Almost all organisms contain the same biosynthetic pathway for the synthesis of l-serine from the glycolytic intermediate, D-3-phosphoglycerate. However, regulation of this pathway varies from organism to organism. Many organisms control the activity of the first enzyme in the pathway, D-3-phosphoglyerate dehydrogenase (PGDH), by feedback inhibition through the interaction of l-serine with the ACT domains within the enzyme. The last enzyme in the pathway, phosphoserine phosphatase (PSP) has also been reported to be inhibited by l-serine...
November 15, 2017: Biochemistry
https://www.readbyqxmd.com/read/29129227/t-and-b-cell-activation-profiles-from-cows-with-and-without-johne-s-disease-in-response-to-in-vitro-stimulation-with-mycobacterium-avium-subspecies-paratuberculosis
#10
Meredith C Frie, Kelly R B Sporer, Brian W Kirkpatrick, Paul M Coussens
Johne's disease (JD) is a chronic wasting disease of ruminants caused by infection with Mycobacterium avium subspecies paratuberculosis (MAP). JD is particularly problematic on US dairy farms: estimates show that over 50% of farms are MAP-contaminated and as many as 91% of dairy herds could be infected. Although estimates vary widely, JD may cost the dairy industry between $200 million and $1.5 billion every year. One major obstacle to JD management is that JD is difficult to detect in many animals, in part due to the variable immunity against MAP demonstrated by JD+ cattle...
December 2017: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/29121939/case-definition-terminology-for-paratuberculosis-johne-s-disease
#11
R J Whittington, D J Begg, K de Silva, A C Purdie, N K Dhand, K M Plain
Paratuberculosis (Johne's disease) is an economically significant condition caused by Mycobacterium avium subsp. paratuberculosis. However, difficulties in diagnosis and classification of individual animals with the condition have hampered research and impeded efforts to halt its progressive spread in the global livestock industry. Descriptive terms applied to individual animals and herds such as exposed, infected, diseased, clinical, sub-clinical, infectious and resistant need to be defined so that they can be incorporated consistently into well-understood and reproducible case definitions...
November 9, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/29121801/usefulness-of-chinese-herbal-medicines-as-host-directed-therapeutics-against-mycobacterial-infections-a-review
#12
Haruaki Tomioka
The high incidence of tuberculosis (TB) in developing countries, the resurgence of TB in industrialized countries, and the world-wide increase in the prevalence of Mycobacterium avium complex infections have prompted the quest for new antimycobacterial drugs. However, the development of such chemotherapeutics is currently making very slow progress. It therefore appears that devising improved administration protocols for clinical treatment against intractable mycobacteriosis using existing chemotherapeutics is more practical than awaiting the development of novel antimycobacterial drugs...
November 9, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29120902/neutralizing-antiinterferon-%C3%AE-autoantibodies-causing-disseminated-mycobacterium-avium-complex-infection-in-an-hiv-infected-patient-on-successful-combination-antiretroviral-therapy
#13
Un-In Wu, Chien-Ching Hung, Sui-Yuan Chang, Yi-Ting Jhong, Hsin-Yun Sun, Jann-Tay Wang, Szu-Min Hsieh, Wang-Huei Sheng, Wen-Chun Liu, Shan-Chwen Chang, Yee-Chun Chen
No abstract text is available yet for this article.
November 28, 2017: AIDS
https://www.readbyqxmd.com/read/29109952/is-tb-testing-associated-with-increased-blood-interferon-gamma-levels
#14
Aideen E Kennedy, Jim O'Mahony, Noel Byrne, John MacSharry, Riona G Sayers
The Republic of Ireland reports a relatively low prevalence of Johne's disease (JD) compared to international counterparts. Postulated reasons for this include a lower average herd size and a grass-based production system. Ireland also engages in high levels of bovine tuberculosis (bTB) testing. As interferon-gamma (IFN-γ) is believed to play a key role in protecting against JD, it is our hypothesis that administration of purified protein derivative (PPD), as part of the bTB test, is associated with a systemic increase in IFN-γ production, which may potentially limit clinical progression of the disease...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29109708/differential-identification-of-mycobacterial-species-using-high-resolution-melting-analysis
#15
Azar D Khosravi, Mohammad Hashemzadeh, Abdolrazagh Hashemi Shahraki, Ali Teimoori
Infections caused by non-tuberculous mycobacteria (NTM) is increasing wordwide. Due to the difference in treatment of NTM infections and tuberculosis, rapid species identification of mycobacterial clinical isolates is necessary for the effective management of mycobacterial diseases treatment and their control strategy. In this study, a cost-effective technique, real-time PCR coupled with high-resolution melting (HRM) analysis, was developed for the differentiation of Mycobacterial species using a novel rpoBC sequence...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29107584/first-molecular-typing-of-mycobacterium-avium-subspecies-paratuberculosis-identified-in-animal-and-human-drinking-water-from-dairy-goat-farms-in-brazil
#16
Isis F Espeschit, Marina C C Souza, Magna C Lima, Maria A S Moreira
Mycobacterium avium subspecies paratuberculosis, the etiologic agent of Johne's disease or paratuberculosis, was identified by culture and/or polymerase chain reaction (PCR) in 50% and 30% of water samples for animal and human consumption, respectively, from ten dairy goat farms in Brazil. IS1311 restriction fragment length polymorphism analysis identified the isolates as cattle type C.
October 12, 2017: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/29098128/hot-tub-lung-a-diagnostic-challenge
#17
Hassaan Yasin, William E Mangano, Paras Malhotra, Ali Farooq, Hesham Mohamed
Hot tub lung (HTL) is a granulomatous lung disease thought to occur as a result of a hypersensitivity response to non-tuberculous mycobacteria (NTM). Typical radiographic findings are diffuse micronodular and/or ground glass opacities. We report an interesting case of HTL that presented with unique radiographic features, making its diagnosis a predicament. A 56-year-old immunocompetent female with chronic dyspnea and dry cough was found to have subcentimeter cavitary nodules, predominantly in the upper lung zones...
August 27, 2017: Curēus
https://www.readbyqxmd.com/read/29097994/benefits-of-genomic-insights-and-crispr-cas-signatures-to-monitor-potential-pathogens-across-drinking-water-production-and-distribution-systems
#18
Ya Zhang, Masaaki Kitajima, Andrew J Whittle, Wen-Tso Liu
The occurrence of pathogenic bacteria in drinking water distribution systems (DWDSs) is a major health concern, and our current understanding is mostly related to pathogenic species such as Legionella pneumophila and Mycobacterium avium but not to bacterial species closely related to them. In this study, genomic-based approaches were used to characterize pathogen-related species in relation to their abundance, diversity, potential pathogenicity, genetic exchange, and distribution across an urban drinking water system...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29097168/synthesis-and-biological-evolution-of-hydrazones-derived-from-4-trifluoromethyl-benzohydrazide
#19
Martin Krátký, Szilvia Bősze, Zsuzsa Baranyai, Jiřina Stolaříková, Jarmila Vinšová
Reflecting the known biological activity of isoniazid-based hydrazones, seventeen hydrazones of 4-(trifluoromethyl)benzohydrazide as their bioisosters were synthesized from various benzaldehydes and aliphatic ketones. The compounds were screened for their in vitro activity against Mycobacterium tuberculosis, nontuberculous mycobacteria (M. avium, M. kansasii), bacterial and fungal strains. The most antimicrobial potent derivatives were also investigated for their cytostatic and cytotoxic properties against three cell lines...
October 21, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29093379/disseminated-cutaneous-infection-of-mycobacterium-colombiense-in-a-patient-with-myelodysplastic-syndrome-a-case-report
#20
Yuichiro Inagaki, Tatsuya Ito, Tomonori Kato, Yoshitaka Ono, Masashi Sawa
Mycobacterium colombiense (M. colombiense) is a member of the Mycobacterium avium complex (MAC). To our knowledge, this is the third case report of an M. colombiense infection. An 80-year-old man, immunocompromised by myelodysplastic syndrome (MDS), developed a skin rash with exfoliation and eruption on his face and scalp. Mycobacteria were detected in pus samples. Broad-range polymerase chain reaction (PCR) revealed the mycobacteria to be M. colombiense. The lesions resolved after daily administration of rifampicin, ethambutol, and clarithromycin...
November 1, 2017: Internal Medicine
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