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https://www.readbyqxmd.com/read/28429679/mycobacterium-avium-complex-disease
#1
Charles L Daley
Despite the ubiqitous nature of Mycobacterium avium complex (MAC) organisms in the environment, relatively few of those who are infected develop disease. Thus, some degree of susceptibility due to either underlying lung disease or immunosuppression is required. The frequency of pulmonary MAC disease is increasing in many areas, and the exact reasons are unknown. Isolation of MAC from a respiratory specimen does not necessarily mean that treatment is required, as the decision to treatment requires the synthesis of clinical, radiographic, and microbiologic information as well as a weighing of the risks and benefits for the individual patient...
April 2017: Microbiology Spectrum
https://www.readbyqxmd.com/read/28428297/complete-genome-sequence-of-mycobacterium-avium-subsp-hominissuis-strain-h87-isolated-from-an-indoor-water-sample
#2
Xueyan Zhao, L Elaine Epperson, Nabeeh A Hasan, Jennifer R Honda, Edward D Chan, Michael Strong, Nicholas D Walter, Rebecca M Davidson
Mycobacterium avium subsp. hominissuis is an environmentally acquired bacterium known to cause pulmonary and soft tissue infections, lymphadenitis, and disseminated disease in humans. We report here the complete genome sequence of strain H87, isolated from an indoor water sample, as a single circular chromosome of 5,626,623 bp with a G+C content of 68.8%.
April 20, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28427555/impact-of-cavity-and-infiltration-on-pulmonary-function-and-health-related-quality-of-life-in-pulmonary-mycobacterium-avium-complex-disease-a-3-dimensional-computed-tomographic-analysis
#3
Takanori Asakura, Yoshitake Yamada, Ho Namkoong, Shoji Suzuki, Yuki Niijima, Hirofumi Kamata, Yohei Funatsu, Kazuma Yagi, Satoshi Okamori, Hiroaki Sugiura, Makoto Ishii, Masahiro Jinzaki, Tomoko Betsuyaku, Naoki Hasegawa
BACKGROUND AND OBJECTIVES: Pulmonary Mycobacterium avium complex (pMAC) disease manifests as various types of lesions, such as infiltrates, nodules, cavities, and bronchiectasis. However, the important determinants for clinical parameters in lung involvement are poorly understood. The objective of this study was to obtain quantitative parameters by 3-dimensional CT, and investigate the relationship between these parameters and the pulmonary function tests (PFTs) and health-related quality of life...
May 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28424429/the-volatile-molecule-signature-of-four-mycobacteria-species
#4
Theodore Mellors, Christiaan Rees, Wendy Wieland-Alter, C Fordham von Reyn, Jane E Hill
Mycobacteria are the leading cause of death from infectious disease worldwide and limitations in current diagnostics are hampering control efforts. In recent years, the use of small volatile molecules as diagnostic biomarkers for mycobacteria has shown promise for use in the rapid analysis of in vitro cultures as well as ex vivo diagnosis using breath or sputum. In this study, 18 strains from four mycobacteria species (Mycobacterium avium, M. bovis BCG, M. intracellulare and M. xenopi) were analyzed for the first time using two-dimensional gas chromatography time-of-flight mass spectrometry (GC×GC-TOFMS)...
April 20, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28423094/complications-of-chronic-necrotizing-pulmonary-aspergillosis-review-of-published-case-reports
#5
Aleksandra Barac, Tatjana Adzic Vukicevic, Aleksandra Dudvarski Ilic, Salvatore Rubino, Vladimir Zugic, Goran Stevanovic
Chronic necrotizing pulmonary aspergillosis (CNPA), a form of chronic pulmonary aspergillosis (CPA), affects immunocompetent or mildly immunocompromised persons with underlying pulmonary disease. These conditions are associated with high morbidity and mortality and often require long-term antifungal treatment. The long-term prognosis for patients with CNPA and the potential complications of CNPA have not been well documented. The aim of this study was to review published papers that report cases of CNPA complications and to highlight risk factors for development of CNPA...
April 13, 2017: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/28422754/mpeg1-perforin-2-mutations-in-human-pulmonary-nontuberculous-mycobacterial-infections
#6
Ryan M McCormack, Eva P Szymanski, Amy P Hsu, Elena Perez, Kenneth N Olivier, Eva Fisher, E Brook Goodhew, Eckhard R Podack, Steven M Holland
Perforin-2 is a highly conserved pore-forming protein encoded by macrophage expressed gene 1 (MPEG1). A number of studies have shown that Perforin-2-deficient mice are unable to survive following a bacterial challenge that is nonlethal in WT mice. There is also recent evidence that Mpeg1+/- heterozygous mice display an intermediate killing ability compared with Mpeg1 WT and Mpeg1-/- mice. Despite these in vivo findings, to date, no perforin-2 deficiencies have been associated with human disease. Here, we report four patients with persistent nontuberculous mycobacterial infection who had heterozygous MPEG1 mutations...
April 20, 2017: JCI Insight
https://www.readbyqxmd.com/read/28422568/cgas-sting-tbk1-irf3-7-induced-interferon-%C3%AE-contributes-to-the-clearing-of-non-tuberculous-mycobacterial-infection-in-mice
#7
Nanthapon Ruangkiattikul, Andreas Nerlich, Ketema Abdissa, Stefan Lienenklaus, Abdulhadi Suwandi, Nina Janze, Kristin Laarmann, Julia Spanier, Ulrich Kalinke, Siegfried Weiss, Ralph Goethe
Type I interferons (IFN-I), such as IFN-α and IFN-β are important messengers in the host response against bacterial infections. Knowledge about the role of IFN-I in infections by nontuberculous mycobacteria (NTM) is limited. Here we show that macrophages infected with pathogens of the Mycobacterium avium complex produced significantly lower amounts of IFN-β than macrophages infected with the opportunistic pathogen M. smegmatis. To dissect the molecular mechanisms of this phenomenon, we focussed on the obligate pathogen Mycobacterium avium ssp...
April 19, 2017: Virulence
https://www.readbyqxmd.com/read/28422564/evaluation-of-two-in-house-immunoenzymatic-tests-to-serodiagnose-subclinical-paratuberculisis-in-a-sheep-flock-in-mexicali-valley-mexico
#8
Elizama Ponce Barraza, Tomás Cárdenas Reyna, Carlos Angulo, José Carlomán Herrera Ramírez, Gilberto V López, Gerardo Enrique Medina-Basulto, Shigetoshi Eda, Sawako Hori-Oshima
Paratuberculosis (PTB) or Johne's disease is a common ruminant infectious disease caused by Mycobacterium avium subsp. paratuberculosis (MAP). In this study, two MAP antigens were compared for their diagnostic utility to detect subclinical PTB in a sheep flock in Mexicali, Mexico. Sheep (n = 31) without clinical signs but positive on a direct fecal-polymerase chain reaction were tested with two preabsorbed in-house enzyme linked immunosorbent assays (ELISAs) using: (1) an ethanol-extracted surface lipid antigen (EVELISA) and (2) a protoplasmic antigen (ELISA-PPA)...
April 19, 2017: Journal of Immunoassay & Immunochemistry
https://www.readbyqxmd.com/read/28418290/invasive-nontuberculous-mycobacterial-infections-among-cardiothoracic-surgical-patients-exposed-to-heater-cooler-devices-1
#9
Meghan M Lyman, Cheri Grigg, Cara Bicking Kinsey, M Shannon Keckler, Heather Moulton-Meissner, Emily Cooper, Minn M Soe, Judith Noble-Wang, Allison Longenberger, Shane R Walker, Jeffrey R Miller, Joseph F Perz, Kiran M Perkins
Invasive nontuberculous mycobacteria (NTM) infections may result from a previously unrecognized source of transmission, heater-cooler devices (HCDs) used during cardiac surgery. In July 2015, the Pennsylvania Department of Health notified the Centers for Disease Control and Prevention (CDC) about a cluster of NTM infections among cardiothoracic surgical patients at 1 hospital. We conducted a case-control study to identify exposures causing infection, examining 11 case-patients and 48 control-patients. Eight (73%) case-patients had a clinical specimen identified as Mycobacterium avium complex (MAC)...
May 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28416214/corrigendum-to-nothing-to-s-cough-at-pulmonary-mycobacterium-avium-complex-infection-am-j-med-2017-130-2-153-156
#10
Michael A Santos, Hardikkumar Patel, Adam Albert
No abstract text is available yet for this article.
April 14, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28413773/a-m-%C3%A2-avium-complex-spondylodiscitis-in-a-middle-aged-woman-with-diabetes
#11
Irini Gerogianni, Stylianos Boutlas, Theophilos Karachalios, Eythymia Petinaki, Marianna Vlychou, K I Gourgoulianis
Spondylodiscitis, the inflammation of the vertebral bodies and the intervertebral disk space, is the reason for low back pain in a minority of cases. This is caused by various pathogens. Mycobacterium tuberculosis is responsible for 17-39% of all the cases of spondylodiscitis. On the contrast, spondylodiscitis from non tuberculous mycobacteria is extremely rare in literature. We describe a 68 -year old diabetic woman which is the first case of bone marrow involvement by M. intracellulare (member of M avium complex)with spondylodiscitis...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28410676/the-immunoregulatory-effects-of-co-infection-with-fasciola-hepatica-from-bovine-tuberculosis-to-johne-s-disease
#12
REVIEW
Amalia Naranjo Lucena, Laura Garza Cuartero, Grace Mulcahy, Annetta Zintl
Fasciola hepatica (liver fluke) is a parasite prevalent in much of the world that causes the economically-important disease of fasciolosis in livestock. The threat that this disease poses extends beyond its direct effects due to the parasite's immunomodulatory effects. Research at this laboratory is focusing on whether this immunoregulation can, in animals infected with liver fluke, exert a bystander effect on concurrent infections in the host. It has already been established that F. hepatica infection reduces cell mediated immune responses to Mycobacterium bovis in cattle, and that the interaction between the two pathogens can be detected on an epidemiological scale...
April 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28408784/prevalence-of-small-ruminant-lentivirus-and-mycobacterium-avium-subsp-paratuberculosis-co-infection-in-ontario-dairy-sheep-and-dairy-goats
#13
Nancy Stonos, Cathy Bauman, Paula Menzies, Sarah K Wootton, Niel A Karrow
Infection with small ruminant lentiviruses (SRLV) causes a variety of chronic inflammatory conditions that limit production. Mycobacterium avium subsp. paratuberculosis (MAP) is also a major production-limiting disease of sheep and goats, which causes severe inflammation of the small intestine. Previous studies have indicated that both SRLV and MAP are widespread in small ruminants in Ontario. This study estimated the prevalence of SRLV and MAP co-infection. Serum samples that were previously tested for MAP infection were re-tested for SRLV...
April 2017: Canadian Journal of Veterinary Research, Revue Canadienne de Recherche Vétérinaire
https://www.readbyqxmd.com/read/28407490/co2-effects-on-the-waterlogging-response-of-gisela-5-and-gisela-6-prunus-cerasusxprunus-canescens-sweet-cherry-prunus-avium-rootstocks
#14
Margarita Pérez-Jiménez, María Hernández-Munuera, M Carmen Piñero, Gregorio López-Ortega, Francisco M Del Amor
Climate change is submitting countries of the Mediterranean arc to periods of drought alternating with heavy rain and waterlogging. Eventual floods along with the rising CO2 in the atmosphere present an unpredictable scenario that affects crop survival. The effect of both stresses combined has been studied in sweet cherry plants. 'Gisela 5' and 'Gisela 6' were evaluated as rootstocks of the sweet cherry cultivar 'Burlat'. Plants were placed in a controlled-climate chamber for 7days, then they were submitted to waterlogging for another 7days and the response to this stress and the subsequent recovery were studied (7 more days)...
March 28, 2017: Journal of Plant Physiology
https://www.readbyqxmd.com/read/28406709/long-term-outcomes-in-a-population-based-cohort-with-respiratory-nontuberculous-mycobacteria-isolation
#15
Emily Henkle, Shannon A Novosad, Sean Shafer, Katrina Hedberg, Sarah A R Siegel, Jennifer Ku, Cara Varley, D Rebecca Prevots, Theodore K Marras, Kevin L Winthrop
RATIONALE: The natural history of nontuberculous mycobacterial (NTM) respiratory infection within the general population is poorly understood. OBJECTIVES: To describe the long-term clinical, microbiologic, and radiographic outcomes of patients with respiratory NTM isolates. METHODS: We previously identified a population-based cohort of patients with respiratory NTM isolation during 2005-6, and categorized patients as cases or non-cases using the ATS/IDSA pulmonary NTM disease criteria at that time...
April 13, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28404681/non-pnca-gene-mutated-but-pyrazinamide-resistant-m-tuberculosis-why-is-that
#16
Jim Werngren, Erik Alm, Mikael Mansjö
Pyrazinamide (PZA) is a key component for the effective treatment of drug susceptible and PZA-susceptible MDR (MDR(PZA-S)) tuberculosis. pncA gene mutations are usually detected in a clear majority (>90%) of the PZA resistant strains but obviously not in all. Rapid and reliable PZA DST is critical whenever PZA will be used in the regimen, not least for the treatment of MDR(PZA-S) TB. In this study, we selected 26 PZA resistant isolates reported to carry a wildtype pncA gene. To confirm resistance, susceptibility testing was repeated to 100 mg/L and 200 mg/L PZA for all the 26 isolates and Sanger sequencing was repeated on the 18 isolates that remained PZA resistant...
April 12, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28399124/dual-color-fluorescence-in-situ-hybridization-fish-assays-for-detecting-mycobacterium-tuberculosis-and-mycobacterium-avium-complexes-and-related-pathogens-in-cultures
#17
Jyotsna Shah, Helena Weltman, Patricia Narciso, Christina Murphy, Akhila Poruri, Shrikala Baliga, Leesha Sharon, Mary York, Gail Cunningham, Steve Miller, Luz Caviedes, Robert Gilman, Edward Desmond, Ranjan Ramasamy
Two rapid dual color fluorescence in situ hybridization (FISH) assays were evaluated for detecting M. tuberculosis and related pathogens in cultures. The MN Genus-MTBC FISH assay uses an orange fluorescent probe specific for the Mycobacterium tuberculosis complex (MTBC) and a green fluorescent probe specific for the Mycobacterium and Nocardia genera (MN Genus) to detect and distinguish MTBC from other Mycobacteria and Nocardia. A complementary MTBC-MAC FISH assay uses green and orange fluorescent probes specific for the MTBC and M...
2017: PloS One
https://www.readbyqxmd.com/read/28397513/paratuberculosis-in-a-domestic-dog-in-south-africa
#18
Michele A Miller, Sewellyn C Davey, Lesley S Van Helden, Frank Kettner, Sandy M May, Rick Last, John D Grewar, Louise Botha, Paul D Van Helden
This case report shows that Mycobacterium avium subsp. paratuberculosis (MAP) infection can cause clinical disease in domestic dogs, and should be considered as a differential diagnosis for gastrointestinal inflammatory conditions. A male dachshund presented with lethargy and pain. Enlarged mesenteric lymph nodes were found on abdominal ultrasound examination. Cytological examination of lymph node aspirates was consistent with granulomatous inflammation, which was culture-confirmed as MAP. Although we were unable to confirm the source of infection, the dog's history included exposure to sheep in the Western Cape...
March 30, 2017: Journal of the South African Veterinary Association
https://www.readbyqxmd.com/read/28392892/evaluation-of-multiple-approaches-to-identify-genome-wide-polymorphisms-in-closely-related-genotypes-of-sweet-cherry-prunus-avium-l
#19
Seanna Hewitt, Benjamin Kilian, Ramyya Hari, Tyson Koepke, Richard Sharpe, Amit Dhingra
Identification of genetic polymorphisms and subsequent development of molecular markers is important for marker assisted breeding of superior cultivars of economically important species. Sweet cherry (Prunus avium L.) is an economically important non-climacteric tree fruit crop in the Rosaceae family and has undergone a genetic bottleneck due to breeding, resulting in limited genetic diversity in the germplasm that is utilized for breeding new cultivars. Therefore, it is critical to recognize the best platforms for identifying genome-wide polymorphisms that can help identify, and consequently preserve, the diversity in a genetically constrained species...
2017: Computational and Structural Biotechnology Journal
https://www.readbyqxmd.com/read/28392413/isolation-and-identification-of-multiple-drug-resistant-nontuberculous-mycobacteria-from-organs-of-cattle-produced-typical-granuloma-lesions
#20
Guangyu Cheng, Donglei Xu, Jinling Wang, Chunfa Liu, Yang Zhou, Yongyong Cui, Hancan Liu, Kanglin Wan, Xiangmei Zhou
Nontuberculosis mycobacteria are widespread in the environment and some are zoonotic. 320 tissue samples with visible lesions were obtained from dairy cows and examined by histopathology. Eleven samples showed typical granulomatous lesions and a total of 8 strains were cultured. Three genes (16S rRNA, hsp65 and rpoB) were sequenced for species identification. All mycobacterial isolates were tested for rifampicin, isoniazid, ethambutol, streptomycin, capreomycin, kanamycin, para-aminosalicylic acid susceptibility...
April 6, 2017: Microbial Pathogenesis
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