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https://www.readbyqxmd.com/read/29234594/successful-use-of-linezolid-for-refractory-mycobacterium-abcessus-infection-a-case-report
#1
Teppei Inoue, Akihito Tsunoda, Eriko Nishimoto, Kohei Nishida, Yuka Komatsubara, Rintaro Onoe, Junko Saji, Masamichi Mineshita
A 51-year-old male patient was receiving treatment for Mycobacterium abscessus infection for approximately 10 years. However, as his condition gradually progressed to type II respiratory insufficiency, he was referred to our hospital, which was near his home. Computed tomography on his first visit revealed an abscess in the right lower lobe. Because respiratory insufficiency was evident, he was admitted the same day. We began treatment with meropenem, amikacin, and clarithromycin, but his symptoms did not improve...
2018: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/29227218/association-between-sequevar-and-antibiotic-treatment-outcome-in-patients-with-mycobacterium-abscessus-complex-infections-in-japan
#2
Shiomi Yoshida, Kazunari Tsuyuguchi, Takehiko Kobayashi, Motohisa Tomita, Yoshikazu Inoue, Seiji Hayashi, Katsuhiro Suzuki
PURPOSE: Macrolide susceptibility differs between subspecies in the Mycobacterium abscessus complex, likely due to differences in erm(41) sequevars. Patients with M. abscessus complex infection generally show poor clinical outcomes in response to antibiotic treatment. Here, the association between genotype and treatment outcome was investigated. METHODOLOGY: We collected 69 isolates from 35 patients with non-cystic fibrosis bronchiectasis: 24 had M. abscessus complex lung disease and non-cystic fibrosis bronchiectasis, and 11 were colonized...
December 11, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29217419/in-vitro-activity-of-tedizolid-against-the-mycobacterium-abscessus-complex
#3
Fabrice Compain, Daria Soroka, Beate Heym, Jean-Louis Gaillard, Jean-Louis Herrmann, Delphine Dorchène, Michel Arthur, Vincent Dubée
Infections due to Mycobacterium abscessus carry a poor prognosis since this rapidly growing mycobacterium is intrinsically resistant to most antibiotics. Here, we evaluate the in vitro activity of the new oxazolidinone tedizolid against a collection of 44M. abscessus clinical isolates. The MIC50s and MIC90s of tedizolid (2 and 8μg/mL, respectively) were 2- to 16-fold lower than those of linezolid. There was no difference between the 3M. abscessus subspecies. Time-kill assays did not show any bactericidal activity at 4- and 8-fold the MIC...
November 10, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29207758/mycobacterium-fortuitum-infection-at-umbilical-hernioplasty-site
#4
Bharti Chogtu, Daliparty Vasudev Malik, Rahul Magazine, Vishnu Prasad Shenoy
Non Tuberculous Mycobacteria (NTM) are a group of rapidly growing mycobacteria and are generally considered to be of low virulence. Of late, there has been an increase in incidence of infections due to these organisms. Among them, Mycobacterium fortuitum, M. chelonae and M. abscessus are the common species which have been identified. Though they are occasionally implicated in pulmonary infections, NTM are very commonly associated with cutaneous infections, especially surgical site infections. Identification of NTM infection at such sites should be suspected when there is delayed healing of the wound...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29205119/activity-of-rifabutin-and-hemi-synthetic-derivatives-against-mycobacterium-abscessus
#5
Ivy B Ramis, Ricardo Figueiredo, Daniela F Ramos, Priscila C B Halicki, Andrea von Groll, Miguel Viveiros, Maria do Ceu Costa, Pedro E A da Silva
BACKGROUND: Mycobacterium abscessus causes a wide range of clinical diseases that are difficult to treat. This microorganism is resistant not only to the classical antituberculosis agents but also to most of the antimicrobials that are currently available, resulting in limited therapeutic options and treatment failure. This scenario stresses the need to search for new drugs with activity against M. abscessus. OBJECTIVE: To evaluate in vitro the antimycobacterial activity and cytotoxicity of rifabutin (RFB 1) and ten derivatives (2-11) against M...
December 3, 2017: Medicinal Chemistry
https://www.readbyqxmd.com/read/29203051/thiamazole-induced-agranulocytosis-leading-to-abscessus-pneumonia-rare-but-challenging
#6
Biljana Lazovic, Vuk Andrejevic, Aleksandar Ivanovic, Vladimir Zugic
No abstract text is available yet for this article.
December 1, 2017: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/29197331/genotyping-and-drug-susceptibility-testing-of-mycobacterial-isolates-from-population-based-tuberculosis-prevalence-survey-in-ghana
#7
Kennedy Kwasi Addo, Samuel Ofori Addo, Gloria Ivy Mensah, Lydia Mosi, Frank Adae Bonsu
BACKGROUND: Mycobacterium tuberculosis complex (MTBC) and Non-tuberculosis Mycobacterium (NTM) infections differ clinically, making rapid identification and drug susceptibility testing (DST) very critical for infection control and drug therapy. This study aims to use World Health Organization (WHO) approved line probe assay (LPA) to differentiate mycobacterial isolates obtained from tuberculosis (TB) prevalence survey in Ghana and to determine their drug resistance patterns. METHODS: A retrospective study was conducted whereby a total of 361 mycobacterial isolates were differentiated and their drug resistance patterns determined using GenoType Mycobacterium Assays: MTBC and CM/AS for differentiating MTBC and NTM as well MTBDRplus and NTM-DR for DST of MTBC and NTM respectively...
December 2, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29193368/curcumin-an-antibiotic-resistance-breaker-against-a-multiresistant-clinical-isolate-of-mycobacterium-abscessus
#8
Emanuela Marini, Mara Di Giulio, Gloria Magi, Silvia Di Lodovico, Maria Enrica Cimarelli, Andrea Brenciani, Antonia Nostro, Luigina Cellini, Bruna Facinelli
Curcumin, a phenolic compound extracted from Curcuma longa, exerts multiple pharmacological effects, including an antimicrobial action. Mycobacterium abscessus, an environmental, nontuberculous, rapidly growing mycobacterium, is an emerging human pathogen causing serious lung infections and one of the most difficult to treat, due to its multidrug resistance and biofilm-forming ability. We wanted to evaluate the antimicrobial and antivirulence activity of curcumin and its ability to synergize with antibiotics against a clinical M...
November 29, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29190796/risk-factors-for-the-development-of-chronic-pulmonary-aspergillosis-in-patients-with-nontuberculous-mycobacterial-lung-disease
#9
Byung Woo Jhun, Woo Jin Jung, Na Young Hwang, Hye Yun Park, Kyeongman Jeon, Eun-Suk Kang, Won-Jung Koh
Nontuberculous mycobacterial lung disease (NTM-LD) is increasingly recognized as an important predisposing condition for the development of chronic pulmonary aspergillosis (CPA), but there are limited data on the risk factors for CPA development in NTM-LD patients. We reviewed the medical records of 566 patients who, at the time of diagnosis of NTM-LD, did not have CPA and who received ≥12 months of treatment for NTM-LD between January 2010 and June 2015. Of these patients, 41 (7.2%) developed CPA (NTM-CPA group), whereas the remaining 525 patients did not develop CPA (NTM group)...
2017: PloS One
https://www.readbyqxmd.com/read/29176967/reporter-based-assays-for-high-throughput-drug-screening-against-mycobacterium-abscessus
#10
Rashmi Gupta, Mandy Netherton, Thomas F Byrd, Kyle H Rohde
Mycobacterium abscessus is a non-tuberculous mycobacterium that causes pulmonary and non-pulmonary infections. M. abscessus is resistant to many chemotherapeutic agents and the current treatment options show poor clinical outcomes. Thus, there is a dire need to find new antimicrobials effective at killing M. abscessus. Screening drug libraries to identify potential antimicrobials has been impeded by the lack of validated HTS assays for M. abscessus. In this study, we developed two 384-well high-throughput screening assays using fluorescent and bioluminescent reporter strains of M...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29176633/epidemiology-and-predictors-of-ntm-pulmonary-infection-in-taiwan-a-retrospective-five-year-multicenter-study
#11
Hung-Ling Huang, Meng-Hsuan Cheng, Po-Liang Lu, Chin-Chung Shu, Jann-Yuan Wang, Jann-Tay Wang, Inn-Wen Chong, Li-Na Lee
Multicenter, longitudinal studies on nontuberculous mycobacteria (NTM) pulmonary infection (PI) are lacking. This study provides a 5-year epidemiological overview of NTM-PI in Taiwan and investigated its predictors. The clinical relevance of each respiratory NTM isolate in six hospitals between 2008 and 2014 was determined according to current guidelines. Recurrent episodes were judged by serial bacteriological results. New episodes of NTM-PI and pulmonary colonization (PC) occurring since 2010 were analyzed...
November 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29173447/clinical-characteristics-and-treatment-outcomes-of-pleural-effusions-in-patients-with-nontuberculous-mycobacterial-disease
#12
Sojung Park, Kyung-Wook Jo, Sang-Do Lee, Woo Sung Kim, Tae Sun Shim
BACKGROUND: The incidence of nontuberculous mycobacterial (NTM) infection has increased over the last 10 years. However, the clinical characteristics and treatment outcomes of patients with NTM pleuritis have not been well defined. METHODS: Patients with pleural effusion and NTM lung disease diagnosed between 1997 and 2013 were enrolled and their medical records were reviewed retrospectively. The subjects were divided into definite (n = 9, NTM isolated from the pleura or pleural effusion) and possible (n = 5, NTM lung disease with pleural effusion and improvement of effusion after anti-NTM treatment) groups...
December 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/29171453/antibiotic-resistance-in-mycobacterium-abscessus-and-mycobacterium-fortuitum-isolates-from-malaysian-patients
#13
Sharmilla Devi Jayasingam, Thaw Zin, Yun Fong Ngeow
BACKGROUND: Rapidly growing mycobacterial species (RGM) are increasingly being recognized as the cause of various superficial and deep infections in humans. Two of the species most frequently isolated from clinical specimens are Mycobacterium abscessus and Mycobacterium fortuitum. Both species are associated with antibiotic resistances that may complicate therapy. This paper describes the pattern of resistance to five antibiotics commonly prescribed for RGM infections, in M. abscessus and M...
October 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/29163541/nucleotide-binding-oligomerization-domain-2-contributes-to-limiting-growth-of-mycobacterium-abscessus-in-the-lung-of-mice-by-regulating-cytokines-and-nitric-oxide-production
#14
Jun-Young Lee, Moo-Seung Lee, Dong-Jae Kim, Soo-Jin Yang, Sang-Jin Lee, Eui-Jeong Noh, Sung Jae Shin, Jong-Hwan Park
Mycobacterium abscessus is a prominent cause of pulmonary infection in immunosuppressed patients and those with cystic fibrosis. Nucleotide-binding oligomerization domain (NOD) 2 is a cytosolic receptor which senses a bacterial peptidoglycan component, muramyl dipeptide (MDP). Although nucleotide-binding oligomerization domain 2 (NOD2) contributes to protect host against various microbial infections, it is still unclear whether NOD2 is essential to regulate host immune responses against M. abscessus infection...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29163413/lipoprotein-glycosylation-by-protein-o-mannosyltransferase-mab_1122c-contributes-to-low-cell-envelope-permeability-and-antibiotic-resistance-of-mycobacterium-abscessus
#15
Katja Becker, Klara Haldimann, Petra Selchow, Lukas M Reinau, Michael Dal Molin, Peter Sander
Lipoproteins are important components of the mycobacterial cell envelope due to their function in cell wall homeostasis and bacterial virulence. They are post-translationally modified with lipid- and glycosyl-residues in various species and interference with acylation or glycosylation leads to reduced growth and attenuated virulence in Mycobacterium tuberculosis. Lipoproteins are also expressed in the emerging and highly drug resistant pathogen Mycobacterium abscessus which frequently affects the lungs of patients with chronic pulmonary disease or cystic fibrosis...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29139343/mycobacterium-abscessus-a-taxonomic-puzzle
#16
Enrico Tortoli, Tomas A Kohl, Barbara A Brown-Elliott, Alberto Trovato, Sylvia Cardoso-Leão, Maria Jesus Garcia, Sruthi Vasireddy, Christine Y Turenne, David E Griffith, Julie V Philley, Stefan Niemann, Richard J Wallace, Daniela M Cirillo
No abstract text is available yet for this article.
November 15, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/29123166/a-temperature-sensitive-mycobacterium-paragordonae-induces-enhanced-protective-immune-responses-against-mycobacterial-infections-in-the-mouse-model
#17
Byoung-Jun Kim, Bo-Ram Kim, Yoon-Hoh Kook, Bum-Joon Kim
Recently, we introduced a temperature sensitive Mycobacterium spp., Mycobacterium paragordonae (Mpg). Here, we checked its potential as a candidate for live vaccination against Mycobacterium tuberculosis and Mycobacterium abscessus. Intravenous infections of mice with Mpg led to lower colony forming units (CFUs) compared to infection with BCG, suggesting its usefulness as a live vaccine. The analyses of immune responses indicated that the highly protective immunity elicited by Mpg was dependent on effective dendritic maturation, shift of cytokine patterns and antibody production toward a Th1 phenotype, and enhanced cytotoxic T cell response...
November 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29122674/antibiofilm-activity-of-nanoemulsions-of-cymbopogon-flexuosus-against-rapidly-growing-mycobacteria
#18
Grazielle Guidolin Rossi, Kevim Bordignon Guterres, Pauline Cordenonsi Bonez, Samanta da Silva Gundel, Vanessa Albertina Aggertt, Fallon Santos Siqueira, Aline Ferreira Ourique, Roger Wagnerd, Bruna Klein, Roberto Christ Vianna Santos, Marli Matiko Anraku de Campos
Rapidly growing mycobacteria (RGM) are opportunistic microorganisms that can cause both local and disseminated infections. When in biofilm, these pathogens become highly resistant to antimicrobials used in clinical practice. Composed abundantly of polymeric substances, biofilms delay the diffusion of antimicrobials, preventing the drug from penetrating the deeper layers and having an effective action. Therefore, the search for new and alternative therapeutic options has become of fundamental importance. Natural products fall into these options, especially essential oils...
November 6, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29121135/sporotrichoid-pattern-of-mycobacterium-chelonae-abscessus-infection
#19
Jessica L Boulavsky, Holly M Wright, Paul M Rodriguez-Waitkus, Andrew R DiNardo, Laila E Woc-Colburn, Harry Dao
No abstract text is available yet for this article.
September 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29109708/differential-identification-of-mycobacterial-species-using-high-resolution-melting-analysis
#20
Azar D Khosravi, Mohammad Hashemzadeh, Abdolrazagh Hashemi Shahraki, Ali Teimoori
Infections caused by non-tuberculous mycobacteria (NTM) is increasing wordwide. Due to the difference in treatment of NTM infections and tuberculosis, rapid species identification of mycobacterial clinical isolates is necessary for the effective management of mycobacterial diseases treatment and their control strategy. In this study, a cost-effective technique, real-time PCR coupled with high-resolution melting (HRM) analysis, was developed for the differentiation of Mycobacterial species using a novel rpoBC sequence...
2017: Frontiers in Microbiology
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