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https://www.readbyqxmd.com/read/29661870/amikacin-inhalation-as-salvage-therapy-for-refractory-nontuberculous-mycobacterial-lung-disease
#1
Byung Woo Jhun, Bumhee Yang, Seong Mi Moon, Hyun Lee, Hye Yun Park, Kyeongman Jeon, O Jung Kwon, Jungmin Ahn, Il Joon Moon, Sung Jae Shin, Charles L Daley, Won-Jung Koh
Although guidelines recommend amikacin (AMK) inhalation therapy for difficult-to-treat nontuberculous mycobacterial lung disease (NTM-LD), data are limited regarding the safety and clinical efficacy of this salvage therapy. We retrospectively evaluated treatment outcomes of 77 patients with refractory NTM-LD caused by Mycobacterium abscessus complex (MABC) or M. avium complex (MAC) who initiated AMK inhalation therapy between February 2015 and June 2016. MABC was the most common etiology (n = 48, 62%), followed by MAC (n = 20, 26%) and mixed infections (n = 9, 12%)...
April 16, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29649431/diagnosis-and-management-of-children-with-mycobacterium-abscessus-infections-in-the-head-and-neck
#2
Justine Moe, Roy Rajan, Shelley Caltharp, Shelly Abramowicz
PURPOSE: Controversy exists regarding the most appropriate treatment strategy for children with nontuberculous mycobacterial (NTM) cervical lymphadenitis. Mycobacterium abscessus (MAB) is an uncommon cause of NTM cervical lymphadenitis. The purpose of the present study was to evaluate diagnosis, management, and treatment outcomes in children with MAB-associated cervical lymphadenitis resulting from a pulpotomy. MATERIALS AND METHODS: This was a retrospective chart review of children with NTM lymphadenitis of the head and neck caused by MAB treated at Children's Healthcare of Atlanta hospitals (Atlanta, GA)...
March 22, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29648588/influence-of-three-dimensional-lung-epithelial-cells-and-interspecies-interactions-on-antibiotic-efficacy-against-mycobacterium-abscessus-and-pseudomonas-aeruginosa
#3
Graciela Rodríguez-Sevilla, Charlotte Rigauts, Eva Vandeplassche, Lisa Ostyn, Ignacio Mahíllo-Fernández, Jaime Esteban, Concepción Pérez-Jorge Peremarch, Tom Coenye, Aurélie Crabbé
Mycobacterium abscessus lung infection is a major health problem for cystic fibrosis (CF) patients. Understanding the in vivo factors that influence the outcome of therapy may help addressing the poor correlation between in vitro and in vivo antibiotic efficacy. We evaluated the influence of interspecies interactions and lung epithelial cells on antibiotic efficacy. Therefore, single and dual species biofilms of M. abscessus and a major CF pathogen (Pseudomonas aeruginosa) were cultured on a plastic surface or on in vivo-like three-dimensional (3-D) lung epithelial cells, and the activity of antibiotics (colistin, amikacin, clarithromycin, ceftazidime) in inhibiting biofilm formation was evaluated...
April 10, 2018: Pathogens and Disease
https://www.readbyqxmd.com/read/29643203/evaluation-of-the-vitek-ms-v3-0-matrix-assisted-laser-desorption-ionization-time-of-flight-mass-spectrometry-system-for-identification-of-mycobacterium-and-nocardia-species
#4
Barbara A Body, Melodie A Beard, E Susan Slechta, Kimberly E Hanson, Adam P Barker, N Esther Babady, Tracy McMillen, Yi-Wei Tang, Barbara A Brown-Elliott, Elena Iakhiaeva, Ravikiran Vasireddy, Sruthi Vasireddy, Terry Smith, Richard J Wallace, S Turner, L Curtis, Susan Butler-Wu, Jenna Rychert
This multi-center study was designed to assess the accuracy and reproducibility of the VITEK MS v3.0 matrix-assisted laser desorption ionization--time of flight (MALDI-TOF) mass spectrometry system for identification of Mycobacterium and Nocardia species compared to DNA sequencing. A total of 963 clinical isolates representing 51 taxa were evaluated. In all, 663 isolates were correctly identified to the species level (69%) with another 231 (24%) correctly identified to the complex or group level. Fifty-five isolates (6%) could not be identified despite repeat testing...
April 11, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29626567/evaluation-of-the-intracellular-activity-of-drugs-against-mycobacterium-abscessus-using-a-thp-1-macrophage-model
#5
Carmen Amelia Molina-Torres, Lorena Taméz-Peña, Jorge Castro-Garza, Jorge Ocampo-Candiani, Lucio Vera-Cabrera
We evaluated the antimicrobial effectiveness against M. abscessus in a THP-1 cell line model. No intracellular activity was observed when using amikacin or imipenem. A bacteriostatic effect was observed for cefoxitin, clarithromycin and azithromycin. Tigecycline showed the best antibacterial effect by decreasing the intracellular growth up to bactericidal level.
April 4, 2018: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/29601108/synthesis-of-avibactam-derivatives-and-activity-on-%C3%AE-lactamases-and-peptidoglycan-biosynthesis-enzymes-of-mycobacteria
#6
Zainab Edoo, Laura Iannazzo, Fabrice Compain, Inès Li de la Sierra Gallay, Herman van Tilbeurgh, Matthieu Fonvielle, Flavie Bouchet, Eva Le Run, Jean-Luc Mainardi, Michel Arthur, Mélanie Ethève-Quelquejeu, Jean-Emmanuel Hugonnet
There is a renewed interest for β-lactams for treating infections due to Mycobacterium tuberculosis and M. abscessus since their β-lactamases are inhibited by classical (clavulanate) or new generation (avibactam) inhibitors, respectively. Here, we report access to an azido derivative of the diazabicyclooctane (DBO) scaffold of avibactam for functionalization by the Huisgen-Sharpless cycloaddition reaction. The amoxicillin-DBO combinations were active indicating that the triazole ring is compatible with drug penetration (minimal inhibitory concentration of 16 µg/ml for both species)...
March 30, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29594066/a-simple-and-rapid-gene-disruption-strategy-in-mycobacterium-abscessus-on-the-design-and-application-of-glycopeptidolipid-mutants
#7
Albertus Viljoen, Ana Victoria Gutiérrez, Christian Dupont, Eric Ghigo, Laurent Kremer
Little is known about the disease-causing genetic determinants that are used by Mycobacterium abscessus , increasingly acknowledged as an important emerging pathogen, notably in cystic fibrosis. The presence or absence of surface exposed glycopeptidolipids (GPL) conditions the smooth (S) or rough (R) M. abscessus subsp. abscessus ( M. abscessus ) variants, respectively, which are characterized by distinct infective programs. However, only a handful of successful gene knock-out and conditional mutants have been reported in M...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29564361/positive-effect-of-liposomal-amikacin-for-inhalation-on-mycobacterium-abcessus-in-cystic-fibrosis-patients
#8
Davide Caimmi, Nicolas Martocq, Delphine Trioleyre, Catherine Guinet, Sylvain Godreuil, Thomas Daniel, Raphael Chiron
Mycobacterium abscessus is difficult to eradicate. At the Montpellier CF Center, we prescribed liposomal amikacin for inhalation to 5 patients with M abscessus infection. The 3 patients who completed the treatment did not have any respiratory exacerbation, showed negative cultures for M abscessus in their sputum, and stabilized their spirometric functions.
March 2018: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29563276/non-tuberculous-mycobacterial-infections-related-to-peritoneal-dialysis
#9
Hiroyuki Inoue, Naoki Washida, Kohkichi Morimoto, Keisuke Shinozuka, Takahiro Kasai, Kiyotaka Uchiyama, Hirobumi Tokuyama, Shu Wakino, Hiroshi Itoh
Most infections related to peritoneal dialysis (PD) are caused by common bacteria, and non-tuberculous mycobacteria are rare. The clinical characteristics and prognosis of PD patients with non-tuberculous mycobacterial infections were investigated at our hospital. Non-tuberculous mycobacteria were detected in 11 patients (exit-site infection, tunnel infection, and peritonitis in 3, 5, and 3 patients, respectively). Mycobacterium fortuitum , Mycobacterium chelonae , and Mycobacterium abscessus were identified in 4, 2, and 2 patients, respectively...
March 2018: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/29562989/discrepancies-between-the-genotypes-and-phenotypes-of-clarithromycin-resistant-mycobacterium-abscessus-complex
#10
S Yoshida, K Tsuyuguchi, T Kobayashi, M Tomita, Y Inoue, S Hayashi, K Suzuki
SETTING: Macrolides are a key drug class used for the treatment of Mycobacterium abscessus complex disease. OBJECTIVE: To verify the relationship between phenotypic susceptibility and genotypic resistance to clarithromycin (CLM). DESIGN: Subspecies of M. abscessus complex from 145 consecutive patients were identified using hsp65 and rpoB gene sequencing, and tested for CLM susceptibility, classification into the erm(41) sequevars responsible for inducible resistance and the presence of rrl mutations associated with acquired resistance...
April 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29556857/skin-and-soft-tissue-infections-due-to-nontuberculous-mycobacteria
#11
REVIEW
Elizabeth Ann Misch, Christopher Saddler, James Muse Davis
PURPOSE OF REVIEW: This review describes recent trends in the epidemiology of nontuberculous mycobacteria (NTM), emerging pathogens, new insights into NTM pathogenesis, and advances in diagnosis and treatment. RECENT FINDINGS: Emerging pathogens include Mycobacterium chimaera and drug-resistant subspecies of Mycobacterium abscessus. Important virulence mechanisms of pathogenic NTM include the ability to alter the macrophage's permissiveness to intracellular bacterial growth...
March 19, 2018: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/29555180/non-tuberculous-mycobacteria-multispecies-biofilms-in-cystic-fibrosis-development-of-an-in-vitro-mycobacterium-abscessus-and-pseudomonas-aeruginosa-dual-species-biofilm-model
#12
Graciela Rodríguez-Sevilla, Marta García-Coca, David Romera-García, John Jairo Aguilera-Correa, Ignacio Mahíllo-Fernández, Jaime Esteban, Concepción Pérez-Jorge
Lung disease in cystic fibrosis (CF) is characterized by the progressive colonization of the respiratory tract by different bacteria, which develop polymicrobial biofilms. In the past decades, there has been an increase in the number of CF patients infected with Non-Tuberculous Mycobacteria (NTM). Although Mycobacterium abscessus is the main NTM isolated globally, little is known about M. abscessus multispecies biofilm formation. In the present study we developed an in vitro model to study the phenotypic characteristics of biofilms formed by M...
March 6, 2018: International Journal of Medical Microbiology: IJMM
https://www.readbyqxmd.com/read/29550059/determination-of-the-antimicrobial-susceptibility-and-molecular-profile-of-clarithromycin-resistance-in-the-mycobacterium-abscessus-complex-in-japan-by-variable-number-tandem-repeat-analysis
#13
Mari Kusuki, Kayo Osawa, Kentaro Arikawa, Miho Tamura, Katsumi Shigemura, Toshiro Shirakawa, Tatsuya Nakamura, Yuji Nakamachi, Masato Fujisawa, Jun Saegusa, Issei Tokimatsu
Mycobacterium abscessus complex, including three subspecies-M. abscessus, M. massiliense, and M. bolletii-is resistant to a variety of antibiotics so limited treatment options are available. The susceptibility of these subspecies to antimicrobial agents depends in particular on the erm(41) sequevar and rrl mutations in the 23S rRNA, which are potentially related to clarithromycin (CLR) resistance. The purpose of this study was to carry out identification and molecular characterization of these subspecies based on variable number of tandem repeats (VNTR) analysis...
February 18, 2018: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29516889/-mycobacterium-abscessus-subsp-abscessus-lung-disease-drug-susceptibility-testing-in-sputum-culture-negative-conversion
#14
Takehiko Kobayashi, Kazunari Tsuyuguchi, Shiomi Yoshida, Yu Kurahara, Naoya Ikegami, Maiko Naito, Shoko Sonobe, Toshiya Maekura, Taisuke Tsuji, Shojiro Minomo, Yoshikazu Inoue, Katsuhiro Suzuki
Background: Among Mycobacterium abscessus complex infections, patients with M. abscessus subsp. abscessus (MAA) lung disease are difficult to treat and no standard therapy has been established. Few reports have investigated the drug susceptibility of these strains. We retrospectively investigated how in vitro drug susceptibility testing (DST) of MAA affects the induction of sputum conversion using pharmacotherapy. Methods: Patients with MAA lung disease diagnosed and treated between 2010 and 2014 at our hospital were enrolled and divided into Group A (sputum conversion without relapse within 1 year) and Group B (persistent positive cultured or negative conversion with relapse)...
January 2018: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/29516885/-in-vitro-activity-of-seven-hospital-biocides-against-mycobacterium-abscessus-implications-for-patients-with-cystic-fibrosis
#15
Steven Caskey, John E Moore, Jacqueline C Rendall
Background: Mycobacterium abscessus pulmonary infection has recently emerged as a significant pathogen in patients with cystic fibrosis (CF) and is associated with significant morbidity and accelerated pulmonary decline. There is a paucity of data describing the activity of hospital biocides against this organism. Methods: M. abscessus isolates (n = 13) were recovered from CF and non-CF respiratory specimens. Seven commonly employed hospital biocides with generic ingredients as follows: acetone, propan-2-ol, diethylene glycol, 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one, chlorine dioxide, 4% chlorhexidine, alcohol, and disodium carbonate, compound with hydrogen peroxide, 10% sodium hypochlorite were assayed for their biocidal activity against M...
January 2018: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/29516862/cutaneous-mycobacteriosis-in-a-captive-amazonian-manatee-trichechus-inunguis
#16
Laura Reisfeld, Cássia Yumi Ikuta, Laura Ippolito, Bruna Silvatti, José Soares Ferreira Neto, José Luiz Catão-Dias, Fernando C W Rosas, José Anselmo Neto, Vera M F da Silva
An adult male Amazonian manatee Trichechus inunguis under human care presented with 3 circular cutaneous lesions on the dorsal aspect of the rostrum and between the nostrils (plenum). Initially these lesions were superficial, hypopigmented, without warmth and non-painful. Microbiological cultures of skin swabs isolated Candida sp. and Pseudomonas aeruginosa, and topical treatment with antiseptic, antifungal, anti-inflammatory and antibiotic medication was instituted. This treatment strategy did not lead to any clinical improvement, and after 6 mo, the lesions progressed to a confluent abscess (5...
March 5, 2018: Diseases of Aquatic Organisms
https://www.readbyqxmd.com/read/29497402/phylogenomics-and-comparative-genomic-studies-robustly-support-division-of-the-genus-mycobacterium-into-an-emended-genus-mycobacterium-and-four-novel-genera
#17
Radhey S Gupta, Brian Lo, Jeen Son
The genus Mycobacterium contains 188 species including several major human pathogens as well as numerous other environmental species. We report here comprehensive phylogenomics and comparative genomic analyses on 150 genomes of Mycobacterium species to understand their interrelationships. Phylogenetic trees were constructed for the 150 species based on 1941 core proteins for the genus Mycobacterium , 136 core proteins for the phylum Actinobacteria and 8 other conserved proteins. Additionally, the overall genome similarity amongst the Mycobacterium species was determined based on average amino acid identity of the conserved protein families...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29483164/the-many-lives-of-nontuberculous-mycobacteria
#18
Tiffany A Claeys, Richard T Robinson
Nontuberculous mycobacteria (NTM) include species that colonize human epithelia, as well as species that are ubiquitous in soil and aquatic environments. NTM that primarily inhabit soil and aquatic environments include the Mycobacterium avium complex (MAC, M. avium and Mycobacterium intracellulare ) and the Mycobacterium abscessus complex (MABSC, M. abscessus subspecies abscessus , massiliense , and bolletii ), and can be free-living, biofilm-associated, or amoeba-associated. Although NTM are rarely pathogenic in immunocompetent individuals, those who are immunocompromised - due to either an inherited or acquired immunodeficiency - are highly susceptible to NTM infection (NTMI)...
February 26, 2018: Journal of Bacteriology
https://www.readbyqxmd.com/read/29483126/clarithromycin-susceptibility-genotype-affects-the-treatment-outcome-of-patients-with-mycobacterium-abscessus-lung-disease
#19
Qi Guo, Haiqing Chu, Meiping Ye, Zhemin Zhang, Bing Li, Shiyi Yang, Wei Ma, Fangyou Yu
Mycobacterium abscessus accounts for a large proportion of lung disease cases caused by rapidly growing mycobacteria. The association between clarithromycin sensitivity and treatment outcome is clear. However, M. abscessus culture and antibiotic susceptibility testing are time-consuming. Clarithromycin-susceptibility genotyping offers an alternate, rapid approach to predicting the efficacy of clarithromycin-based antibiotic therapy. M. abscessus lung disease patients were divided into two groups based upon the clarithromycin-susceptibility genotype of the organism isolated...
February 26, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29483110/gold-iii-macrocycles-and-chelates-targeting-mycobacterium-tuberculosis-and-mycobacterium-abscessus-evidence-for-inhibition-of-topoisomerase-1a
#20
Rashmi Gupta, Carolina R Felix, Matthew P Akerman, Kate J Akerman, Cathryn A Slabber, Wenjie Wang, Jessie Adams, Lindsey N Shaw, Yuk-Ching Tse-Dinh, Orde Q Munro, Kyle H Rohde
Mycobacterium tuberculosis ( Mtb ) and the fast-growing Mycobacterium abscessus ( Mab ) are two important human pathogens causing persistent pulmonary infections that are difficult to cure and require long treatment times. The emergence of drug resistant Mtb strains and the high level of intrinsic resistance of Mab calls for novel drug scaffolds that effectively target both pathogens. In this study, we have evaluated the activity of bis(pyrrolide-imine) gold(III) macrocycles and chelates, originally designed as DNA intercalators capable of targeting human topoisomerase I and II, against Mab and Mtb...
February 26, 2018: Antimicrobial Agents and Chemotherapy
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