Kavita De, Juan M Belardinelli, Arun Prasad Pandurangan, Teddy Ehianeta, Elena Lian, Zuzana Palčeková, Ha Lam, Mercedes Gonzalez-Juarrero, Josephine M Bryant, Tom L Blundell, Julian Parkhill, R Andres Floto, Todd L Lowary, William H Wheat, Mary Jackson
Mycobacterium abscessus is increasingly recognized as the causative agent of chronic pulmonary infections in humans. One of the genes found to be under strong evolutionary pressure during adaptation of M. abscessus to the human lung is embC which encodes an arabinosyltransferase required for the biosynthesis of the cell envelope lipoglycan, lipoarabinomannan (LAM). To assess the impact of patient-derived embC mutations on the physiology and virulence of M. abscessus , mutations were introduced in the isogenic background of M...
April 23, 2024: Proceedings of the National Academy of Sciences of the United States of America