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Ned Kinnear, Bridget Heijkoop, Lina Hua, Derek B Hennessey, Daniel Spernat
Background: To examine the effect of intra-operative cell salvage (ICS) in open radical prostatectomy. Methods: In this retrospective cohort study, all patients undergoing open radical prostatectomy for malignancy at our institution between 10/04/2013 and 10/04/2017 were enrolled. Patients were grouped and compared based on whether they received ICS. Primary outcomes were allogeneic transfusion rates, and disease recurrence. Secondary outcomes were complications and transfusion-related cost...
May 2018: Translational Andrology and Urology
Ruqayyah J Almizraq, Jelena L Holovati, Jason P Acker
Background: Extracellular vesicles (EVs) in blood products are potential effectors of inflammation and coagulation after transfusion. The aim of this study was to assess the impact of different blood manufacturing methods and duration of hypothermic storage on the EV subpopulations in relation to other in vitro quality parameters of red blood cell concentrate (RCC) products. Methods: RCCs were produced using whole blood filtration (WBF) or red cell filtration (RCF) (n = 12/method), refrigerated for 43 days, and evaluated for EV size profile and concentration, red cell deformability, ATP and 2,3-DPG, hemolysis, and hematological indices...
May 2018: Transfusion Medicine and Hemotherapy
Nicoletta Orlando, Maria Bianchi, Caterina Giovanna Valentini, Maddalena Maresca, Giuseppina Massini, Rossana Putzulu, Gina Zini, Luciana Teofili
Background: The detection of irregular antibody is a critical issue in the management of red blood cell transfusion according to the Type & Screen (T&S) practice. In order to implement the T&S procedure at our blood bank, we compared three different automated analyzers based on column agglutination technique (CAT) or solid phase red cell adherence assay (SPACA) methods. Methods: Pre-transfusion antibody screening was performed in 986 patients candidate to elective surgery at low risk for red blood cell transfusion...
May 2018: Transfusion Medicine and Hemotherapy
Johanna Reckhaus, Markus Jutzi, Stefano Fontana, Vera Ulrike Bacher, Marco Vogt, Michael Daslakis, Behrouz Mansouri Taleghani
Background: Platelet concentrates (PC) contain residual contaminating red blood cells (RBC), being higher in pooled buffy coat PC (BC-PC) than in apheresis units (AP-PC). Data about PC-induced alloimmunization against non-D Rhesus (Rh) antigens are limited. Methods: For all newly detected RhD and non-D alloantibodies between August 2015 and September /2017 we prospectively evaluated if they were triggered through PC by analyzing for incompatible RBC and/or PC transfusions...
May 2018: Transfusion Medicine and Hemotherapy
Ana Villalba, Marta Santiago, Carmen Freiria, Pau Montesinos, Ines Gomez, Carolina Fuentes, Rebeca Rodriguez-Veiga, José María Fernandez, Guillermo Sanz, Miguel Angel Sanz, Nelly Carpio, Pilar Solves
Background: Anti-D alloimmunization can occur when platelets from RhD-positive donors are transfused to RhD-negative patients, due to red blood cell residues in the platelet concentrates. Methods: Our objective was to analyze the anti-D alloimmunization rate in a selected group of women under 55 years of age diagnosed with acute leukemia over an 18-year period. We focused the analysis on RhD-negative patients who received RhD-positive platelet transfusions. Results: From January 1998 to October 2016, 382 women under 55 years were diagnosed with acute leukemia...
May 2018: Transfusion Medicine and Hemotherapy
Sabine Flommersfeld, Carsten Mand, Christian A Kühne, Gregor Bein, Steffen Ruchholtz, Ulrich J Sachs
Background: Immediate supply of red blood cell (RBC) concentrates is crucial in the initial treatment of exsanguinating patients in the emergency room. General shortage of RhD- RBCs has led to protocols in which patients with unknown blood groups are initially transfused with group O, RhD+ RBCs. Limited data are available regarding the safety of such an approach. Methods: Transfusion protocols for all multiple injured patients from the regional polytrauma database were retrospectively analyzed over a period of 5 years...
May 2018: Transfusion Medicine and Hemotherapy
Markus Jutzi, Behrouz Mansouri Taleghani, Morven Rueesch, Lorenz Amsler, Andreas Buser
Introduction: Bacterial contamination of platelet concentrates (PCs) has been identified as the most prevalent transfusion-associated infectious risk. To prevent PC-related septic transfusion reactions, the Intercept® pathogen inactivation procedure was introduced for all PCs in Switzerland in 2011. Methods: Based on numbers of transfused units and mandatorily reported adverse events with high imputability, we compare the risks associated with transfusion of conventional PCs (cPCs) and pathogen-inactivated PCs (PI-PCs)...
May 2018: Transfusion Medicine and Hemotherapy
Anneliese Synnot, Peter Bragge, Carole Lunny, David Menon, Ornella Clavisi, Loyal Pattuwage, Victor Volovici, Stefania Mondello, Maryse C Cnossen, Emma Donoghue, Russell L Gruen, Andrew Maas
OBJECTIVE: To appraise the currency, completeness and quality of evidence from systematic reviews (SRs) of acute management of moderate to severe traumatic brain injury (TBI). METHODS: We conducted comprehensive searches to March 2016 for published, English-language SRs and RCTs of acute management of moderate to severe TBI. Systematic reviews and RCTs were grouped under 12 broad intervention categories. For each review, we mapped the included and non-included RCTs, noting the reasons why RCTs were omitted...
2018: PloS One
Arun Saini, Alina N West, Camden Harrell, Tamekia L Jones, Marianne E Nellis, Ashwini D Joshi, Krista M Cowan, Connor W Gatewood, Alex B Ryder, Ulrike M Reiss
OBJECTIVES: Pediatric intensivists frequently prescribe platelet transfusions to critically ill children, but there are limited data on platelet transfusion practice and platelet transfusion-related outcomes in the PICU. In this study, we evaluated the current platelet transfusion practice and platelet transfusion-related outcomes in the PICU. DESIGN: Institutional review board-approved, retrospective cohort study from January 2010 to March 2016. SETTING: Tertiary-level PICU...
June 20, 2018: Pediatric Critical Care Medicine
Martin Wepler, Tamara Merz, Ulrich Wachter, Josef Vogt, Enrico Calzia, Angelika Scheuerle, Peter Möller, Michael Gröger, Sandra Kress, Marina Fink, Britta Lukaschewski, Grégoire Rumm, Bettina Stahl, Michael Georgieff, Markus Huber-Lang, Roberta Torregrossa, Matthew Whiteman, Oscar McCook, Peter Radermacher, Clair Hartmann
Hemorrhagic shock (HS) accounts for 30-40% of trauma-induced mortality, which is due to multi-organ-failure subsequent to systemic hyper-inflammation, triggered by hypoxemia and tissue ischemia. The slow-releasing, mitochondria-targeted H2S donor AP39 exerted beneficial effects in several models of I/R-injury and acute inflammation. Therefore, we tested the effects of AP39-treatment in a murine model of combined blunt chest trauma (TxT) and HS with subsequent resuscitation. METHODS: After blast wave-induced TxT or sham procedure, anesthetized and instrumented mice underwent 1 hour of hemorrhage followed by 4 hours of resuscitation comprising an i...
June 20, 2018: Shock
V Houyhongthong, W Nunphuak, C Sripatumtong, C Parnsamut, C Ketloy
INTRODUCTION: In current laboratory practice, obtaining a nucleated red blood cell (NRBC) count by manual microscopy (MM) is a laborious and time-consuming process. Modern hematology analyzers based on different technologies and methods have variable accuracies when determining NRBC counts. The aim of this study was to compare NRBC counts acquired by an automated Mindray BC-6800 analyzer (BC-6800), a flow cytometry (FC) reference method, and traditional MM. METHODS: A hundred EDTA samples with initial NRBC flags from the BC-6800 were included...
June 21, 2018: International Journal of Laboratory Hematology
Sezaneh Haghpanah, Tahereh Zarei, Peyman Eshghi, Omidreza Zekavat, Mohammadreza Bordbar, Mahmood Hoormand, Mehran Karimi
Recently, resveratrol showed induction of γ-globin mRNA synthesis in human erythroid precursors and reducing oxidative stress in red cells of thalassemia patients in many in vitro studies. We aimed to investigate the efficacy and safety of resveratrol, for the first time, in non-transfusion-dependent beta-thalassemia intermedia (B-TI) in Southern Iran. In this double-blind randomized clinical trial, 54 patients with B-TI were investigated during 6 months between October 2016 and March 2017. Patients were randomly allocated into three groups by simple randomization method...
June 21, 2018: Annals of Hematology
Paolo Ricchi, Antonella Meloni, Laura Pistoia, Anna Spasiano, Alessandra Spiga, Massimo Allò, Maria Rita Gamberini, Roberto Lisi, Saveria Campisi, Angelo Peluso, Massimiliano Missere, Stefania Renne, Maurizio Mangione, Vincenzo Positano, Alessia Pepe
We prospectively assessed by magnetic resonance imaging (MRI) the advantages of desferrioxamine (DFO) with respect to the absence of chelation therapy in non transfusion-dependent thalassaemia (NTDT) patients. We considered 18 patients non-chelated and 33 patients who received DFO alone between the two MRI scans. Iron overload was assessed by the T2* technique. Biventricular function parameters were quantified by cine sequences. No patient treated with DFO had cardiac iron. At baseline, only one non-chelated patient showed a pathological heart T2* value (< 20 ms) and he recovered at the follow-up...
June 21, 2018: Annals of Hematology
Adriano Petrangelo, Eman Alshehri, Nicholas Czuzoj-Shulman, Haim A Abenhaim
OBJECTIVE: Pregnancies in women affected by a muscular dystrophy are at an increased risk of adverse maternal and neonatal outcomes due to the effect of the disease on the muscular, cardiac and respiratory systems. We sought to evaluate the risk of adverse outcomes within a large population-based cohort study. METHODS: We used the data extracted from the Nationwide Inpatient Sample (NIS) to conduct a retrospective population-based cohort study consisting of over 12 million births that occurred in the United States between 1999 and 2013...
June 20, 2018: Journal of Perinatal Medicine
Nina S Cohen, Michael J Goretsky, Robert J Obermeyer
BACKGROUND: Hemorrhage during Nuss bar removal is an uncommon but feared complication that can be life threatening if not controlled rapidly. This study aims to identify the incidence and sources of large volume hemorrhage, discuss successful management strategies, and provide patient care recommendations. METHODS: An IRB approved (#15-11-WC-0214), single institution retrospective chart review was performed on patients who underwent Nuss bar removal over a 15-year interval...
June 20, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
Chuanyin Sun, Yingwan Luo, Hongyan Tong, Guanhua Xu, Jin Lin
RATIONALE: Dysregulated immune function in rheumatoid arthritis (RA) might lead to the development of myelodysplastic syndrome (MDS). Serum interleukin-6 (IL-6) concentrations are increased in both RA and MDS patients. PATIENT CONCERNS: A 58-year-old woman presented with severe RA. During a recent 8-month period, the patient experienced swelling in multiple joints, dizziness, and severe anemia. The symptoms responded poorly to oral corticosteroids and methotrexate (MTX)...
June 2018: Medicine (Baltimore)
Betty Leclerc, Lucie Salomon Du Mont, Anne-Laure Parmentier, Guillaume Besch, Simon Rinckenbach
BACKGROUND: The abdominal compartment syndrome (ACS) has been clearly identified as being one of the main causes of mortality after ruptured abdominal aortic aneurysm (rAAA). The ACS is defined as a sustained intra-abdominal pressure > 20 mm Hg associated with a new organ dysfunction or failure. A pilot study was conducted and found that the threshold of 3 among 8 selected criteria, we would predict an ACS occurrence with a 54% positive predictive value and a 92% negative predictive value...
June 2018: Medicine (Baltimore)
Sarah M Weinstein, Jacques T YaDeau, Stavros G Memtsoudis
BACKGROUND AND OBJECTIVES: Previous research suggests that increased duration and lower levels of intraoperative hypotension (IOH) are associated with postoperative acute kidney injury (AKI). However, this association has not been evaluated in the context of intraoperative controlled hypotension (IOCH), a practice that has been linked in the past to improved outcomes with respect to blood loss and transfusion needs. This study aimed to investigate whether IOCH is associated with postoperative AKI among total hip arthroplasty patients at an institution where this technique is commonly practiced...
June 19, 2018: Regional Anesthesia and Pain Medicine
P Ursi, A Santoro, A Gemini, A Arezzo, D Pironi, C Renzi, R Cirocchi, F M Di Matteo, A Maturo, V D'Andrea, J Sagar
BACKGROUND: Low Rectal Anterior Resection (LAR) is challenging when anal canal mucosa and/or internal sphincter are involved by very low tumors. In these cases, Intersphincteric resection (ISR) with the removal of the internal sphincter is designed to increase the distal margin of resection, thus preserving the external sphincter and pubo-rectalis muscle complex. Aim is to compare results after ISR with those of LAR, including subgroup analysis of open, laparoscopic and robotic ISR. METHODS: Studies published from January 1991 to January 2017 describing ISR and comparing results with LAR in adults were included irrespective of the technique...
May 2018: Il Giornale di Chirurgia
Y Sawamura, H Ohto, K Ikeda, T Kanno, Y Suzuki, K Gonda, T Tasaki, K E Nollet, H Takahashi, S Aota
BACKGROUND: Although prestorage leucoreduction (LR) of blood components for transfusion has gained favour around the world, evidence of its beneficial clinical effects is ambiguous. STUDY DESIGN AND METHODS: To reveal whether leucocytes and/or platelets in transfused blood are related to transfusion-related adverse effects, a prospective randomized crossover study was performed on patients who donated autologous blood prior to elective surgery. Among 1487 primary enrolees, a total of 192 patients undergoing two-stage, bilateral total hip arthroplasty were randomized to receive autologous blood that was either prestorage leucoreduced, or not, for the first procedure...
June 20, 2018: Vox Sanguinis
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