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https://www.readbyqxmd.com/read/28333279/inhibition-of-pim1-kinase-attenuates-inflammation-induced-pro-labour-mediators-in-human-fetal-membranes-in-vitro
#1
Ratana Lim, Gillian Barker, Martha Lappas
STUDY QUESTION: Does proviral integration site for Moloney murine leukemic virus (PIM)1 kinase play a role in regulating the inflammatory processes of human labour and delivery? SUMMARY ANSWER: PIM1 kinase plays a critical role in fetal membranes in regulating pro-inflammatory and pro-labour mediators. WHAT IS KNOWN ALREADY: Infection and inflammation have strong causal links to preterm delivery by stimulating pro-inflammatory cytokines and collagen degrading enzymes, which can lead to rupture of membranes...
March 9, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28326517/labour-in-women-with-gestational-diabetes-mellitus
#2
Klaudia Grabowska, Angelika Stapińska-Syniec, Aleksandra Saletra, Patrycja Jarmużek, Dorota Bomba-Opoń
OBJECTIVES: Gestational diabetes mellitus (GDM) constitutes one of the most common pregnancy complications and affects 3-5% of all pregnancies, with its incidence still growing. Due to possible maternal and fetal complications, the peripartum management of GDM patients continues to be a debatable issue. The aim of the study was to analyse the course and final way of delivery in women with gestational diabetes mellitus. The effectiveness of induction of labour (IOL) was also assessed and factors predisposing to cesarean section were identified...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/28325126/trial-of-labour-after-caesarean-section-two-year-analysis-at-a-portuguese-centre
#3
Joao Abreu-Silva, Jorge Castro, Catarina Maia, Manuela Pinho, Claudina Carvalho
We conducted a retrospective study aimed at determining variables associated with a higher success rate for vaginal delivery after caesarean section, and assessing the impact of induction of labour. Secondarily, we aimed to describe our vaginal delivery and uterine rupture rates with the use of a controlled-release dinoprostone vaginal insert for cervical ripening. Of 292 women who met the inclusion criteria, induction of labour occurred in 48% (94% with dinoprostone). There was a non-significant difference between the vaginal delivery rate of spontaneous labour (57%) and induction of labour (33%), after adjusting for confounding variables...
March 21, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28321847/antenatal-corticosteroids-for-accelerating-fetal-lung-maturation-for-women-at-risk-of-preterm-birth
#4
REVIEW
Devender Roberts, Julie Brown, Nancy Medley, Stuart R Dalziel
BACKGROUND: Respiratory morbidity including respiratory distress syndrome (RDS) is a serious complication of preterm birth and the primary cause of early neonatal mortality and disability. While researching the effects of the steroid dexamethasone on premature parturition in fetal sheep in 1969, Liggins found that there was some inflation of the lungs of lambs born at gestations at which the lungs would be expected to be airless. Liggins and Howie published the first randomised controlled trial in humans in 1972 and many others followed...
March 21, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28315935/double-balloon-catheter-for-induction-of-labour-in-women-with-a-previous-cesarean-section-could-it-be-the-best-choice
#5
Carlos De Bonrostro Torralba, Eva Lucía Tejero Cabrejas, Sabina Marti Gamboa, María Lapresta Moros, Jose Manuel Campillos Maza, Sergio Castán Mateo
INTRODUCTION: We analysed the efficacy and safety of double-balloon catheter for cervical ripening in women with a previous cesarean section and which were the most important variables associated with an increased risk of repeated cesarean delivery. MATERIALS AND METHODS: We designed an observational retrospective study of 418 women with unfavourable cervices (Bishop Score <5), a prior cesarean delivery, and induction of labour with a double-balloon catheter...
March 18, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28304080/maternal-age-is-a-risk-factor-for-caesarean-section-following-induction-of-labour
#6
Liam Dunn, Sailesh Kumar, Michael Beckmann
BACKGROUND: In Australia, more than 20% of women giving birth are 35 years or older. Advanced maternal age (AMA) is a risk factor for stillbirth, and many clinicians now recommend induction of labour (IOL) at around term gestation. The aim of this study is to determine if AMA is associated with emergency caesarean section (CS) following IOL. METHODS: A retrospective cohort study was undertaken using routinely collected de-identified data. Live-born, singleton, cephalic, non-anomalous pregnancies undergoing IOL between 37 + 0 and 42 + 0 weeks were included...
March 17, 2017: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28302182/qualitative-assessment-of-women-s-satisfaction-with-maternal-health-care-in-referral-hospitals-in-nigeria
#7
Friday Okonofua, Rosemary Ogu, Kingsley Agholor, Ola Okike, Rukiyat Abdus-Salam, Mohammed Gana, Abdullahi Randawa, Eghe Abe, Adetoye Durodola, Hadiza Galadanci
BACKGROUND: Available evidence suggests that the low use of antenatal, delivery, and post-natal services by Nigerian women may be due to their perceptions of low quality of care in health facilities. This study investigated the perceptions of women regarding their satisfaction with the maternity services offered in secondary and tertiary hospitals in Nigeria. METHODS: Five focus group discussions (FGDs) were held with women in eight secondary and tertiary hospitals in four of the six geo-political zones of the country...
March 16, 2017: Reproductive Health
https://www.readbyqxmd.com/read/28297186/the-new-obstetrical-dilemma-stunting-obesity-and-the-risk-of-obstructed-labour
#8
Jonathan C K Wells
The "obstetrical dilemma" refers to the tight fit between maternal pelvic dimensions and neonatal size at delivery. Most interest traditionally focused on its generic significance for humans, for example our neonatal altriciality and our complex and lengthy birth process. Across contemporary populations, however, the obstetrical dilemma manifests substantial variability, illustrated by differences in the incidence of cephalo-pelvic disproportion, obstructed labour and cesarean section. Beyond accounting for 12% of maternal mortality worldwide, obstructed labour also imposes a huge burden of maternal morbidity, in particular through debilitating birth injuries...
April 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/28295174/predictors-of-mode-of-birth-and-duration-of-labour-following-induction-using-prostaglandin-vaginal-gel
#9
Michael Beckmann, Kristen Gibbons, Vicki Flenady, Sailesh Kumar
BACKGROUND AND AIMS: Using data from a randomised controlled trial (RCT) comparing two policies of prostaglandin (PGE2) vaginal gel induction of labour (IOL) at term, this study aimed to determine: (i) demographic/clinical factors that predict IOL outcomes; and (ii) clinical characteristic(s) of women who would benefit from a policy of amniotomy once technically possible as opposed to giving more PGE2. MATERIAL AND METHODS: Following an initial PGE2 dose, women were randomised to amniotomy or repeat-PGE2...
March 13, 2017: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28292361/effectiveness-of-per-rectal-misoprostol-versus-intramuscular-oxytocin-for-prevention-of-primary-postpartum-haemorrhage
#10
Raheela Asmat, Tasneem Ashraf, Fazila Asmat, Shakila Asmat, Nagina Asmat
OBJECTIVE: To compare the effectiveness of per rectal misoprostol over oxytocin in primary postpartum haemorrhage (PPH). STUDY DESIGN: Randomised controlled trial study. PLACE AND DURATION OF STUDY: Gynaecology and Obstetrics Department, Unit IV, Bolan Medical Complex Hospital, Quetta, from September 2013 to February 2014. METHODOLOGY: Emergency obstetric patients receiving per rectal misoprostol (800 µgm) were named as group 'A' and those receiving 10 units oxytocin intramuscularly were labelled as group 'B'...
January 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28286995/date-fruit-consumption-at-term-effect-on-length-of-gestation-labour-and-delivery
#11
Nuguelis Razali, Siti Hayati Mohd Nahwari, Sofiah Sulaiman, Jamiyah Hassan
Labour induction and augmentation with Prostaglandin and Oxytocin are well established as standard practice worldwide. They are safe when used judiciously, but may be associated with maternal and neonatal morbidities. Other safer alternatives have been studied including dates consumption during late pregnancy with various outcomes. The aim of this randomised controlled trial was to investigate the effect of date fruit consumption during late pregnancy on the onset of labour and need for induction or augmentation of labour...
March 13, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28281576/incidence-and-outcomes-of-uterine-rupture-among-women-with-prior-caesarean-section-who-multicountry-survey-on-maternal-and-newborn-health
#12
Kenichiro Motomura, Togoobaatar Ganchimeg, Chie Nagata, Erika Ota, Joshua P Vogel, Ana Pilar Betran, Maria Regina Torloni, Kapila Jayaratne, Seung Chik Jwa, Suneeta Mittal, Zenaida Dy Recidoro, Kenji Matsumoto, Mikiya Fujieda, Idi Nafiou, Khalid Yunis, Zahida Qureshi, Joao Paulo Souza, Rintaro Mori
Caesarean section (CS) is increasing globally, and women with prior CS are at higher risk of uterine rupture in subsequent pregnancies. However, little is known about the incidence, risk factors, and outcomes of uterine rupture in women with prior CS, especially in developing countries. To investigate this, we conducted a secondary analysis of the World Health Organization Multicountry Survey on Maternal and Newborn Health, which included data on delivery from 359 facilities in 29 countries. The incidence of uterine rupture among women with at least one prior CS was 0...
March 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28267443/balloon-removal-after-fetoscopic-endoluminal-tracheal-occlusion-for-congenital-diaphragmatic-hernia
#13
Julio A Jiménez, Elisenda Eixarch, Philip Dekoninck, João R Bennini, Roland Devlieger, Cleisson F Peralta, Eduard Gratacos, Jan Deprest
BACKGROUND: Isolated congenital diaphragmatic hernia (CDH) defect allows viscera to herniate into the chest, competing for space with the developing lungs. At birth, pulmonary hypoplasia leads to respiratory insufficiency and persistent pulmonary hypertension that is lethal in up to 30% of patients. Antenatal measurement of lung size and liver herniation can predict survival after birth. Prenatal intervention aims at stimulating lung development, clinically achieved by percutaneous fetal endoscopic tracheal occlusion (FETO) under local anesthesia...
March 3, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28260689/foley-catheter-for-induction-of-labour-filled-with-30ml-or-60ml-a-randomized-controlled-trial
#14
Evelien M Sandberg, Evy M Schepers, Rosalie L van Sitter, Claartje M A Huisman, Wim J van Wijngaarden
OBJECTIVES: One of the methods used to induce labour is the placement of a transcervical Foley catheter (FC). The aim of this randomized controlled study was to assess in term pregnant women with an unfavourable cervix, whether there is a difference in efficacy between the two most commonly used insufflation volumes of FC (30mL and 60mL). STUDY DESIGN: Randomized controlled trial. RESULTS: Women were randomized to induction of labour with a Foley catheter filled with 30mL or with 60mL...
February 24, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28258944/caesarean-delivery-in-a-pregnant-woman-with-epidermolysis-bullosa-anaesthetic-challenges
#15
M Araújo, R Brás, R Frada, L Guedes-Martins, P Lemos
Epidermolysis bullosa is a heterogeneous group of hereditary diseases characterised by extreme fragility of skin and mucosa, with blister and lesion formation spontaneously or in response to trauma. Anaesthetic management of these patients is challenging with respect to positioning, monitoring, use of medical devices and airway management. These challenges are increased when managing labour. We report an elective caesarean delivery in a nulliparous woman with autosomal recessive dystrophic epidermolysis bullosa, managed successfully with spinal anaesthesia...
February 3, 2017: International Journal of Obstetric Anesthesia
https://www.readbyqxmd.com/read/28253206/invasive-therapies-for-primary-post-partum-haemorrhage-as-missed-opportunities-for-medical-prevention
#16
Gilles Kayem, Catherine Deneux-Tharaux
PURPOSE OF REVIEW: Examine the available results from population-based studies to test the hypothesis that differences between countries in medical practices for the management of labour, delivery and early bleeding may lead to a differential risk of post-partum haemorrhage (PPH)-related maternal morbidity and in the need for PPH-related invasive therapies. RECENT FINDINGS: International comparison of ratios of maternal mortality due to PPH shows significant differences between developed countries...
April 2017: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28252306/-pregnancy-outcomes-in-women-with-gestational-diabetes-specific-subgroups-might-require-increased-attention
#17
V Bartáková, V Ťápalová, K Wágnerová, P Janků, J Bělobrádková, K Kaňková
OBJECTIVES: To compare peri-partal parameters between two groups of pregnant women - with and without gestational diabetes mellitus (GDM), to correlate degree of glucose abnormality with incidence of peri-partal morbidity and, finally, to analyse the potential effect of comorbidities (i.e. obesity, hypertension, thyreopathy, polycystic ovary syndrome, trombophylia, anemia, allergy, smoking) on pregnancy outcomes. DESIGN: Epidemiological observational "case-control" study...
2017: Ceská Gynekologie
https://www.readbyqxmd.com/read/28251639/induction-of-labour-using-balloon-catheter-and-prostaglandin-gel
#18
COMPARATIVE STUDY
Jacqueline Brown, Michael Beckmann
BACKGROUND: The process of induction of labour (IOL) commonly involves cervical ripening, using mechanical or pharmacological methods. However, the optimum protocol of IOL remains undetermined. AIMS: To report the maternal, neonatal and process outcomes for women being induced with a balloon catheter or prostaglandin E2 gel (PGE2). MATERIALS AND METHODS: Matched retrospective cohort study of women requiring IOL at term with a modified Bishop's score (MBS) <7...
February 2017: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28251626/intrapartum-intervention-rates-and-perinatal-outcomes-following-induction-of-labour-compared-to-expectant-management-at-term-from-an-australian-perinatal-centre
#19
COMPARATIVE STUDY
Yi Zhao, Christopher Flatley, Sailesh Kumar
BACKGROUND: Induction of labor (IOL) is a common obstetric intervention, yet its impact on intervention rates and perinatal outcomes is conflicting. AIMS: To evaluate the impact of IOL on intrapartum intervention rates and perinatal outcomes in women with singleton pregnancies at term. MATERIAL AND METHODS: This was a retrospective, cross-sectional study of term singleton deliveries at the Mater Mother's Hospital in Brisbane, Australia in 2007-2013...
February 2017: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28244641/resident-consultant-obstetrician-presence-on-the-labour-ward-versus-other-models-of-consultant-cover-a-systematic-review-of-intrapartum-outcomes
#20
REVIEW
J Henderson, J J Kurinczuk, M Knight
BACKGROUND: Several key policy documents have advocated 24-hour consultant obstetrician presence on the labour ward as a means of improving the safety of birth. However, it is unclear what published evidence exists comparing the outcomes of intrapartum care with 24-hour consultant labour ward presence and other models of consultant cover. OBJECTIVES: To collate and critically appraise evidence of the effect of continuous resident consultant obstetrician cover on the labour ward on outcomes of intrapartum care compared with other models of consultant cover...
February 28, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
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