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https://www.readbyqxmd.com/read/29675506/large-osteochondral-allografts-of-the-knee-surgical-technique-and-indications
#1
REVIEW
Gabriele Pisanu, Umberto Cottino, Federica Rosso, Davide Blonna, Antonio Giulio Marmotti, Corrado Bertolo, Roberto Rossi, Davide E Bonasia
Large osteochondral allograft (OCA) transplant has become a valid alternative to restore articular surface in challenging articular lesions in young and active patients, either in primary or in revision procedures. Several studies support the effectiveness and safety of OCA, but costs and graft availability limit their use. The indications are the treatment of symptomatic full-thickness cartilage lesions greater than 3 cm 2 , deep lesions with subchondral damage, or revision procedures when a previous treatment has failed...
March 2018: Joints
https://www.readbyqxmd.com/read/29667926/proximal-tibia-stress-fracture-with-osteoarthritis-of-knee-radiological-and-functional-analysis-of-one-stage-tka-with-long-stem
#2
Dhanasekaran Soundarrajan, Natesan Rajkumar, Palanisamy Dhanasekararaja, Shanmuganathan Rajasekaran
INTRODUCTION: Proximal tibia stress fractures with knee osteoarthritis pose a challenging situation. We evaluated the radiological and functional outcome of one-stage total knee arthroplasty (TKA) and long stem for patients with varied grades of knee arthritis and proximal tibia stress fractures.  Methods: We analysed 20 patients from April 2012 to March 2017 with proximal tibia stress fractures associated with knee osteoarthritis of varied grades. Out of 20 patients, five were acute fresh fractures...
2018: SICOT-J
https://www.readbyqxmd.com/read/29650375/vascularized-distal-radius-bone-graft-for-treatment-of-ulnar-nonunion
#3
REVIEW
Ezequiel Ernesto Zaidenberg, Ezequiel Martinez, Carlos Rodolfo Zaidenberg
Various methods have been reported to treat forearm nonunions with good results. However, in the presence of infection, inadequate vascularity of surrounding tissues, or failed prior grafts, vascularized bone grafts are a valid alternative. We describe the surgical technique to obtain distal radius vascularized bone graft pedicled on the radial artery (RA) and its clinical application in 1 case of an ulnar nonunion. We studied the surgical technique in 12 freshly injected cadavers. In the distal forearm, the RA provides several periosteal branches to supply the distal radius metaphysis...
April 9, 2018: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29628315/a-bigger-suture-diameter-for-anterior-cruciate-ligament-all-inside-graft-link-preparation-leads-to-better-graft-stability-an-anatomical-specimen-study
#4
Thomas M Tiefenboeck, Lena Hirtler, Markus Winnisch, Julian Joestl, Thomas Koch, Micha Komjati, Marcus Hofbauer, Roman C Ostermann
BACKGROUND: In anterior cruciate ligament reconstruction, different suture types are used for graft link preparation. Thus the aim of this study was to determine whether differences in the diameter of the suture used influence biomechanical stability of the prepared graft. We hypothesized that the use of a greater suture diameter leads to a higher load to failure rate in tested graft links. METHODS: In an anatomic specimen study, ligament preparation was enrolled in 15 cadaveric knees...
April 5, 2018: Knee
https://www.readbyqxmd.com/read/29601985/mechanical-characterization-and-numerical-simulation-of-a-subcutaneous-implantable-3d-printed-cell-encapsulation-system
#5
Federica Adamo, Marco Farina, Usha R Thekkedath, Alessandro Grattoni, Raffaella Sesana
Cell transplantation in bioengineered scaffolds and encapsulation systems has shown great promise in regenerative medicine. Depending on the site of implantation, type of cells and their expected function, these systems are designed to provide cells with a physiological-like environment while providing mechanical support and promoting long-term viability and function of the graft. A minimally invasive 3D printed system termed neovascularized implantable cell homing and encapsulation (NICHE) was developed in polylactic acid for subcutaneous transplantation of endocrine cells, including pancreatic islets...
March 21, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29577520/the-impact-of-thromboelastography-on-resuscitation-in-pediatric-liver-transplantation
#6
Joseph Sujka, Katherine W Gonzalez, Kayla L Curiel, James Daniel, Ryan T Fischer, Walter S Andrews, Brian M Wicklund, Richard J Hendrickson
Although TEG directs effective resuscitation in adult surgical patients, pediatric data are lacking. We performed a retrospective comparative review of the effect of TEG on blood product utilization and outcomes following pediatric liver transplantation in 38 patients between 2008 and 2014. Diagnoses, laboratory values, fluid and blood product use, and outcomes were examined. Nineteen patients underwent liver transplantation prior to the implementation of TEG, and 19 had perioperative TEG. The most common indications for transplant were BA (n = 14), HB (n = 7), and metabolic disorders (n = 7)...
March 26, 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29576501/intrastriatal-transplantation-of-stem-cells-from-human-exfoliated-deciduous-teeth-reduces-motor-defects-in-parkinsonian-rats
#7
Nan Zhang, Xianjie Lu, Shichao Wu, Xueli Li, Jing Duan, Chao Chen, Wei Wang, Hao Song, Jiabei Tong, Sen Li, Yanming Liu, Xinjiang Kang, Xuexiang Wang, Fabin Han
BACKGROUND: This study explored the neural differentiation and therapeutic effects of stem cells from human exfoliated deciduous teeth (SHED) in a rat model of Parkinson's disease (PD). METHODS: The SHED were isolated from fresh dental pulp and were induced to differentiate to neurons and dopamine neurons by inhibiting similar mothers against dpp (SMAD) signaling with Noggin and increase conversion of dopamine neurons from SHED with CHIR99021, Sonic Hedgehog (SHH) and FGF8 in vitro...
March 22, 2018: Cytotherapy
https://www.readbyqxmd.com/read/29573913/fresh-osteochondral-allograft-transplantation-for-treatment-of-large-cartilage-defects-of-the-femoral-head-a-minimum-two-year-follow-up-study-of-twenty-two-patients
#8
Xin Y Mei, Ibrahim S Alshaygy, Oleg A Safir, Allan E Gross, Paul R Kuzyk
BACKGROUND: Controversy remains over the surgical management of large osteochondral lesions of the femoral head in young, active patients. The purpose of this study is to assess midterm clinical and radiographic outcomes after fresh osteochondral allograft transplantation (OAT) for large femoral head lesions at minimum 2-year follow-up. METHODS: A retrospective review of prospectively collected data was performed for 22 patients under the age of 50 years with defined femoral head osteochondral lesions who underwent fresh OAT between 2008 and 2015...
February 9, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29572391/infusion-of-donor-derived-cd8-memory-t-cells-for-relapse-following-allogeneic-hematopoietic-cell-transplantation
#9
Lori Muffly, Kevin Sheehan, Randall Armstrong, Kent Jensen, Keri Tate, Andrew R Rezvani, David Miklos, Sally Arai, Judith Shizuru, Laura Johnston, Everett Meyer, Wen-Kai Weng, Ginna G Laport, Robert S Negrin, Sam Strober, Robert Lowsky
Murine models showed that CD8+ CD44hi memory T (TM ) cells could eradicate malignant cells without inducing graft-versus-host disease (GVHD). We evaluated the feasibility and safety of infusing freshly isolated and purified donor-derived phenotypic CD8+ TM cells into adults with disease relapse after allogeneic hematopoietic cell transplantation (HCT). Phenotypic CD8 TM cells were isolated after unmobilized donor apheresis using a tandem immunomagnetic selection strategy of CD45RA depletion followed by CD8+ enrichment...
March 27, 2018: Blood Advances
https://www.readbyqxmd.com/read/29570765/effect-of-bisphosphonate-pretreatment-on-fresh-osteochondral-allografts-analysis-of-in-vitro-graft-structure-and-in-vivo-osseous-incorporation
#10
Drew D Moore, Kevin C Baker, Erin A Baker, Mackenzie M Fleischer, Michael D Newton, Nicholas Barreras, Zachary M Vaupel, Paul T Fortin
Fresh allograft transplantation of osteochondral defects restores functional articular cartilage and subchondral bone; however, rapid loss of chondrocyte viability during storage and osteoclast-mediated bone resorption at the graft-host interface after transplantation negatively impact outcomes. The authors present a pilot study evaluating the in vitro and in vivo impact of augmenting storage media with bisphosphonates. Forty cylindrical osteochondral cores were harvested from femoral condyles of human cadaveric specimens and immersed in either standard storage media or storage media supplemented with nitrogenated or non-nitrogenated bisphosphonates...
March 23, 2018: Orthopedics
https://www.readbyqxmd.com/read/29569518/do-selective-serotonin-reuptake-inhibitors-increase-the-risk-of-bleeding-or-mortality-following-coronary-artery-bypass-graft-surgery-a-meta-analysis-of-observational-studies
#11
Martyn J Eckersley, Amir H Sepehripour, Roberto Casula, Prakash Punjabi, Thanos Athanasiou
INTRODUCTION: Depressive illness has a high prevalence in patients undergoing coronary artery bypass graft surgery (CABG). The first line treatment for depression are selective serotonin reuptake inhibitors (SSRIs) which inhibit serotonin reuptake in the presynaptic neuronal membrane and uptake by platelets, inhibiting subsequent serotonin-mediated platelet activation. This presents a theoretically increased risk of bleeding and subsequent postoperative mortality. This review aims to investigate the effects of SSRIs on postoperative bleeding, defined as the need for transfusions and re-operation for bleeding, as well as 30-day mortality in patients undergoing CABG...
March 1, 2018: Perfusion
https://www.readbyqxmd.com/read/29561493/lacrimal-apparatus-procurement-in-face-transplantation
#12
Asif Hasan, Colin Maciver, Gaoussou Toure, Jean-Paul Meningaud
The aesthetic outcome of a well-planned and executed vascularized composite tissue face allotransplant is unquestionable; however, complete functional restoration is necessary. The authors studied the possibility of restoring tear duct function in face transplant recipients. They also examined the technical specifics and feasibility of incorporating a lacrimal drainage apparatus into facial allografting. The authors performed a standardized face vascularized composite allograft on 4 hemi-faces (2 fresh cadavers)...
March 20, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29554436/biomechanical-evaluation-of-the-medial-stabilizers-of-the-patella
#13
Matthew D LaPrade, Samantha L Kallenbach, Zachary S Aman, Gilbert Moatshe, Hunter W Storaci, Travis Lee Turnbull, Elizabeth A Arendt, Jorge Chahla, Robert F LaPrade
BACKGROUND: Quantification of the biomechanical properties of each individual medial patellar ligament will facilitate an understanding of injury patterns and enhance anatomic reconstruction techniques by improving the selection of grafts possessing appropriate biomechanical properties for each ligament. PURPOSE: To determine the ultimate failure load, stiffness, and mechanism of failure of the medial patellofemoral ligament (MPFL), medial patellotibial ligament (MPTL), and medial patellomeniscal ligament (MPML) to assist with selection of graft tissue for anatomic reconstructions...
March 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29550821/blocking-cd226-promotes-allogeneic-transplant-immune-tolerance-and-improves-skin-graft-survival-by-increasing-the-frequency-of-regulatory-t-cells-in-a-murine-model
#14
Tian Liu, Dongliang Zhang, Yuan Zhang, Xiangsheng Xu, Bo Zhou, Liang Fang, Yun Zhang, Yingjun Su, Boquan Jin, Ran Zhuang, Shuzhong Guo
BACKGROUND/AIMS: Regulatory T cells (Tregs) play key roles in maintaining peripheral tolerance and preventing autoimmune disease. Treg modulation could be helpful in treating malignancies, autoimmune disease, and allergies, as well as to facilitate organ transplantation. Signals transduced by co-stimulatory molecules are essential for Treg differentiation, homeostasis, and function. One well-known active receptor, CD226, also known as DNAM-1 or PTA1, is an adhesion molecule that interacts primarily with CD155 and is involved in Treg differentiation and immune tolerance to transplanted tissue...
March 13, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29542884/ovarian-tissue-vitrification-and-heterotopic-autologous-transplantation-in-prepubertal-wistar-rats
#15
Leticia Wietcovsky, David Til, Rafael Alonso Salvador, Nicole Louise Lângaro Amaral, Alfred Paul Senn, Vera Lucia Lângaro Amaral
OBJECTIVE: To evaluate the efficiency of ovarian tissue heterotopic autografting after vitrification in prepubertal rats. METHODS: Fragments of excised ovaries from prepubertal rats were used after assessing post-warming cellular viability, to determine the best vitrification protocol prior to retroauricular autografting. Pre-pubertal females (N=24) were castrated and divided into three group: Group 1 - fresh ovarian tissue transplantation; Group 2 - vitrified/warmed tissue transplantation; Group 3 - bilateral oophorectomy without transplantation...
March 15, 2018: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/29536572/multiple-genetically-modified-gtko-hcd46-hla-e-h%C3%AE-2-mg-porcine-hearts-are-protected-from-complement-activation-and-natural-killer-cell-infiltration-during-ex-vivo-perfusion-with-human-blood
#16
Jan-Michael Abicht, Riccardo Sfriso, Bruno Reichart, Matthias Längin, Katja Gahle, Gisella L Puga Yung, Jörg D Seebach, Robert Rieben, David Ayares, Eckhard Wolf, Nikolai Klymiuk, Andrea Baehr, Alexander Kind, Tanja Mayr, Andreas Bauer
BACKGROUND: In pig-to-human xenotransplantation, early cellular rejection reactions are mediated by natural killer cells (NK cells). Human NK cells are inhibited by HLA-E via CD94/NKG2A receptors. To protect porcine grafts against human NK cell responses, transgenic GTKO pigs expressing hCD46 and HLA-E have been generated. The aim of this study was to test the effect of this genetic modification on xenogeneic, and in particular human NK cell response, using an ex vivo perfusion model of pig hearts with human blood...
March 14, 2018: Xenotransplantation
https://www.readbyqxmd.com/read/29532525/effect-of-socket-grafting-with-deproteinized-bone-mineral-an-rct-on-dimensional-alterations-after-6-months
#17
Cristiano Tomasi, Mauro Donati, Denis Cecchinato, Isacco Szathvary, Enrico Corrà, Jan Lindhe
OBJECTIVE: To examine if (i) characteristics of the fresh extraction socket site influenced subsequent dimensional alterations and (ii) placement of deproteinized bovine mineral in the socket affected volumetric change during healing. MATERIALS AND METHODS: Twenty seven subjects and 28 extraction sites were included. Immediately after the removal of the tooth and after 6 months of healing, stone and virtual models of the jaw were produced. A cone beam computerized tomography scan was obtained immediately after extraction and the thickness of the buccal bone wall at the extraction site was measured...
March 13, 2018: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/29518707/characterization-and-application-of-size-sorted-zonal-chondrocytes-for-articular-cartilage-regeneration
#18
Lu Yin, Yingnan Wu, Zheng Yang, Vinitha Denslin, Xiafei Ren, Ching Ann Tee, Zhangxing Lai, Chwee Teck Lim, Jongyoon Han, Eng Hin Lee
Current clinical approaches for articular cartilage repair have not been able to restore the tissue with zonal architecture, and its biomechanical and functional properties. Mimicking the zonal organization of articular cartilage in neo-tissue by implanting zonal chondrocyte subpopulations in multilayer construct could enhance the functionality of the graft, engineering of stratified tissue has not yet been realized due to lack of efficient and specific zonal chondrocyte isolation protocol. We show that by using a spiral microchannel device, the superficial, middle and deep zone chondrocytes can be separated based on cell size, and enriched from full thickness porcine cartilage in a high-throughput, label-free manner...
March 1, 2018: Biomaterials
https://www.readbyqxmd.com/read/29514363/comparison-of-techniques-for-preimplantation-treatment-of-osteochondral-allograft-bone
#19
Charles A Baumann, John R Baumann, Chantelle C Bozynski, Aaron M Stoker, James P Stannard, James L Cook
Articular defects are a major problem with few effective treatment options. Osteochondral allograft (OCA) transplantation can be an effective treatment; however, lack of OCA bone integration can cause failure. This controlled laboratory study was designed to compare clinically applicable methods for marrow element removal and enhanced delivery of bone marrow aspirate concentrate (BMC) to OCA bone. We hypothesized that compressed carbon dioxide (CO2 ) treatment of OCA bone would result in significantly better marrow element removal, significantly more retention and distribution of viable osteoprogenitor cells, and significantly higher osteoinductive protein elution from OCAs compared with other preimplantation treatments...
March 7, 2018: Journal of Knee Surgery
https://www.readbyqxmd.com/read/29512738/poly-adp-ribose-polymerase-inhibitor-olaparib-hampers-placental-growth-factor-driven-activation-of-myelomonocytic-cells
#20
Pedro Miguel Lacal, Maria Grazia Atzori, Federica Ruffini, Lucio Tentori, Grazia Graziani
The vascular endothelial growth factor receptor-1 (VEGFR-1) is a tyrosine kinase receptor activated by the angiogenic factors VEGF‑A and placental growth factor (PlGF). While VEGF‑A binds to both VEGFR‑1 and VEGFR‑2, PlGF interacts exclusively with VEGFR‑1 triggering a signaling pathway involved in: i) tumor‑associated angiogenesis; ii) chemotaxis and invasion of the extracellular matrix (ECM) by cancer cells; and iii) mobilization of bone marrow‑derived myeloid cells that generate tumor‑associated macrophages...
March 5, 2018: Oncology Reports
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