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https://www.readbyqxmd.com/read/28530850/fresh-osteochondral-allograft-transplantation-is-graft-storage-time-associated-with-clinical-outcomes-and-graft-survivorship
#1
Kenneth J Schmidt, Luís E Tírico, Julie C McCauley, William D Bugbee
BACKGROUND: Regulatory concerns and the popularity of fresh osteochondral allograft (OCA) transplantation have led to a need for prolonged viable storage of osteochondral grafts. Tissue culture media allow a longer storage time but lead to chondrocyte death within the tissue. The long-term clinical consequence of prolonged storage is unknown. HYPOTHESIS: Patients transplanted with OCAs with a shorter storage time would have lower failure rates and better clinical outcomes than those transplanted with OCAs with prolonged storage...
May 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28530120/osteochondral-allograft-transplantation-and-opening-wedge-tibial-osteotomy-clinical-results-of-a-combined-single-procedure
#2
Albert C Hsu, Luis E P Tirico, Abraham G Lin, Pamela A Pulido, William D Bugbee
Objective To evaluate the outcome of patients who have undergone simultaneous osteotomy and osteochondral allograft (OCA) transplantation. Our hypothesis is that use of high tibial osteotomy and fresh OCA in a combined procedure is safe and effective without increasing morbidity in comparison to OCA alone. Design A case series of 17 patients underwent tibial osteotomy and simultaneous OCA during a single surgery. Osteotomy was indicated when axial alignment was within the affected compartment. Patients had a minimum of 2 years of follow-up after surgery...
May 1, 2017: Cartilage
https://www.readbyqxmd.com/read/28509328/anatomy-based-dmek-wetlab-in-homburg-saar-novel-aspects-of-donor-preparation-and-host-maneuvers-to-teach-descemet-membrane-endothelial-keratoplasty
#3
B Seitz, L Daas, M Bischoff-Jung, N Szentmáry, S Suffo, M El-Husseiny, A Viestenz, G Milioti
INTRODUCTION: Use of Descemet Membrane Endothelial Keratoplasty (DMEK) has been limited because of problems with donor preparation, i.e. tearing of the Descemet membrane and difficulties in unfolding the Endothelium-Descemet-Membrane-Layer (EDML) in the anterior chamber (AC). The purpose of this work was to describe a novel approach to teaching anatomy-based donor and recipient preparation in a DMEK-Wetlab. MATERIAL AND METHODS: We teach successful mono-manual donor preparation of human corneas in organ culture not suitable for transplantation, including peripheral markers for orientation...
May 16, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/28508515/extra-oral-digital-scanning-and-imaging-superimposition-for-volume-analysis-of-bone-remodeling-after-tooth-extraction-with-and-without-2-types-of-particulate-porcine-mineral-insertion-a-randomized-controlled-trial
#4
Antonio Barone, Paolo Toti, Giovan-Battista Menchini-Fabris, Giacomo Derchi, Simone Marconcini, Ugo Covani
BACKGROUND: Incorporation of bone substitute material into the extraction socket could minimize the edentulous ridge volume loss or maximize the bone formation within the healing area. PURPOSE: The aim of the study was to test the effectiveness in maintaining the volumetric contour of fresh extraction sockets grafted with or without 2 types of porcine biomaterials and covered with a resorbable barrier. MATERIALS AND METHODS: In the present multi-center single-blind randomized control trial, 55 patients underwent 1-tooth extraction, were surveyed, and randomly allocated to control- (25 sites, nat-group) or test groups (15 sites grafted with pre-hydrated collagenated cortico-cancellous porcine bone, coll-group, and 15 with cortical porcine bone, cort-group)...
May 16, 2017: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/28507875/digital-joint-reconstruction-with-osteotendinous-joint-allograft-experimental-study-in-rats
#5
Martin Iglesias, Ángel Uriel Cruz-Reyes, Patricia Butrón, Ricardo Hernández-Agallo, Víctor Antonio Torres de la Barrera, Claudio Reyes-Montero, Marta Durand-Carbajal, Gonzalo Torres-Villalobos
BACKGROUND: Fresh or frozen nonvascularized osteotendinous joint allografts (OTJA) have not been used previously, clinically or experimentally, for metacarpophalangeal joint reconstruction. Therefore, we evaluated the viability of OTJA for metatarsophalangeal joint (MTJ) reconstruction in rats. METHODS: In the experimental group of 12 Lewis rats, we reconstructed the MTJ of the third digit of the hindlimb with a fresh, nonvascularized OTJA obtained from the same digit from 12 donor rats...
April 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28503733/long-term-safety-from-transmission-of-porcine-endogenous-retrovirus-after-pig-to-non-human-primate-corneal-transplantation
#6
Hyuk Jin Choi, Jiyeon Kim, Jae Young Kim, Hyun Ju Lee, Won Ryang Wee, Mee Kum Kim, Eung Soo Hwang
BACKGROUND: The risk of xenozoonosis mainly by porcine endogenous retrovirus (PERV) has been considered as one of the main hurdles in xenotransplantation and therefore should be elucidated prior to the clinical use of porcine corneal grafts. Accordingly, an investigation was performed to analyze the infectivity of PERVs from porcine keratocytes to human cells, and the long-term risk of transmission of PERVs was determined using pig-to-non-human primate (NHP) corneal transplantation models...
May 14, 2017: Xenotransplantation
https://www.readbyqxmd.com/read/28503127/the-role-of-platelet-function-analyzer-testing-in-cardiac-surgery-transfusion-management
#7
Dejana Bogdanic, Nenad Karanovic, Jela Mratinovic-Mikulandra, Branka Paukovic-Sekulic, Dijana Brnic, Ivanka Marinovic, Diana Nonkovic, Nikolina Bogdanic
BACKGROUND: Identifying high-risk patients for transfusion after cardiac operations would alter postoperative management. The aim of this study was to investigate closure time (CT) measured by platelet function analyzer (PFA) for prediction of bleeding and transfusions. METHODS: 66 patients were scheduled for coronary artery bypass graft (CABG) surgery and 30 patients for valve repair and replacement (non-CABG). Measurements of PFA-100® CT for collagen and adenosine diphosphate (cADP) and collagen and epinephrine (cEPI) were performed 15 min after protamine administration...
April 2017: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/28500505/rehydration-improves-the-ductility-of-dry-bone-allografts
#8
Roger Erivan, Guillaume Villatte, Régis Cueff, Stéphane Boisgard, Stéphane Descamps
Processing of bone allografts improves infectious safety and allows storing bone substitutes at room temperature. The aim of this study was to compare mechanical properties of the processed Osteopure™ bone with fresh frozen bone. All the samples were pieces from femoral heads retrieved during hip arthroplasty operations. The processing includes chemical decellularization, drying and irradiation with 25 kGy. Three types of samples were tested: 1. fresh frozen thawed wet, 2. dry non-rehydrated graft 3. dry rehydrated graft...
May 12, 2017: Cell and Tissue Banking
https://www.readbyqxmd.com/read/28499921/anterior-cruciate-ligament-soft-tissue-graft-fixation-in-the-elderly-is-there-a-reason-to-use-interference-screws-a-human-cadaver-study
#9
Christoph Domnick, Mirco Herbort, Michael J Raschke, Sarah Habermann, Benedikt Schliemann, Wolf Petersen, André Weimann
PURPOSE: To analyze the ultimate failure load, yield load, stiffness, and cyclic resistance of different anterior cruciate ligament (ACL) soft tissue graft fixation techniques in osteopenic bone. METHODS: In this study, 24 fresh-frozen human cadaveric tibiae (mean age 82.6 years; range 56-96; 6 male and 6 female donors) were used. Quantitative computed tomography was performed to match bone density. Looped porcine flexor tendon grafts were chosen as ACL graft substitutes for tibial graft fixation techniques (n = 8 each): (1) hybrid fixation with an interference screw and extracortical button fixation; (2) extracortical button fixation; and (3) interference screw fixation...
May 9, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28494781/preparation-and-characterization-of-small-diameter-decellularized-scaffolds-for-vascular-tissue-engineering-in-an-animal-model
#10
Shuangyue Xu, Fangna Lu, Lianna Cheng, Chenglin Li, Xu Zhou, Yuan Wu, Hongxing Chen, Kaichuang Zhang, Lumin Wang, Junjie Xia, Guoliang Yan, Zhongquan Qi
BACKGROUND: The development of a suitable extracellular matrix (ECM) scaffold is the first step in vascular tissue engineering (VTE). Synthetic vascular grafts are available as an alternative to autologous vessels in large-diameter arteries (>8 mm) and medium-diameter arteries (6-8 mm). In small-diameter vessels (<6 mm), synthetic vascular grafts are of limited use due to poor patency rates. Compared with a vascular prosthesis, natural tissue ECM has valuable advantages. Despite considerable progress in recent years, identifying an optimal protocol to create a scaffold for use in small-diameter (<6 mm) fully natural tissue-engineered vascular grafts (TEVG), remains elusive...
May 11, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28492743/presence-of-cells-in-fresh-frozen-allogeneic-bone-grafts-from-different-tissue-banks
#11
Libério França Coutinho, Juliano Batista do Amaral, Érico Brito Dos Santos, Elizabeth Ferreira Martinez, Victor Angelo M Montalli, José Luiz Cintra Junqueira, Vera Cavalcanti de Araújo, Marcelo Henrique Napimoga
Bone replacement materials have been widely used to reconstruct atrophic jawbones. Based on previous reports demonstrating the presence of viable cells in bone blocks even after processing by musculoskeletal tissue banks for orthopedic use, the aim of this study was to evaluate the presence of cells in bone blocks from three Brazilian tissue banks for maxillary reconstructions. All samples were processed by the respective tissue banks, according to the guidelines of the Brazilian National Sanitary Surveillance Agency...
March 2017: Brazilian Dental Journal
https://www.readbyqxmd.com/read/28486783/extracorporeal-shock-wave-therapy-in-situ-a-novel-approach-to-obtain-an-activated-fat-graft
#12
E Priglinger, M Sandhofer, A Peterbauer-Scherb, C Wurzer, C Steffenhagen, J Maier, W Holnthoner, S Nürnberger, H Redl, S Wolbank
One of the mainstays of facial rejuvenation strategies is volume restoration which can be achieved by autologous fat grafting. In our novel approach, we treated the adipose tissue harvest site with extracorporeal shock wave therapy (ESWT) in order to improve the quality of the regenerative cells in situ. The latter was demonstrated by characterizing the cells of the stromal vascular fraction (SVF) in the harvested liposuction material regarding cell yield, ATP content, proliferative capacity, surface marker profile, differentiation potential and secretory protein profile...
May 9, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28483612/stent-graft-deployment-increases-aortic-stiffness-in-an-ex-vivo-porcine-model
#13
Hector W L de Beaufort, Michele Conti, Arnoud V Kamman, Foeke J H Nauta, Ettore Lanzarone, Frans L Moll, Joost A van Herwaarden, Ferdinando Auricchio, Santi Trimarchi
BACKGROUND: Aortic stiffness is an independent predictor of cardiovascular mortality. In this study, the effect of thoracic endovascular aortic repair (TEVAR) on aortic stiffness is investigated by measuring aortic pulse wave velocity (PWV) in an ex-vivo porcine model. METHODS: Fifteen fresh porcine thoracic aortas were connected to a benchtop pulsatile system. Intraluminal pressures were recorded in the ascending aorta and at the celiac trunk using a needle connected to a pressure sensor...
May 5, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28480504/the-feasibility-of-gamma-radiation-sterilization-for-decellularized-tracheal-grafts
#14
Christopher M Johnson, DeHuang Guo, Stephanie Ryals, Gregory N Postma, Paul M Weinberger
OBJECTIVES/HYPOTHESIS: The most promising stem cell-derived tracheal transplantation approach is dependent upon the use of decellularized tracheal grafts. It has been assumed that a sterilization step, such as gamma radiation, would damage the delicate extracellular matrix of the graft, thus rendering it less viable for cellular repopulation, although this has not been thoroughly investigated. STUDY DESIGN: Laboratory-based comparative analysis. METHODS: Fifteen murine tracheas of strain C57/B-6 mice were obtained...
May 7, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28477147/high-interspecimen-variability-in-engagement-of-the-anterolateral-ligament-an-in-vitro-cadaveric-study
#15
REVIEW
Robert N Kent, James F Boorman-Padgett, Ran Thein, Jelle P van der List, Danyal H Nawabi, Thomas L Wickiewicz, Carl W Imhauser, Andrew D Pearle
BACKGROUND: Anterolateral ligament (ALL) reconstruction as an adjunct to anterior cruciate ligament (ACL) reconstruction remains a subject of clinical debate. This uncertainty may be driven in part by a lack of knowledge regarding where, within the range of knee motion, the ALL begins to carry force (engages). QUESTIONS/PURPOSES: (1) Does the ALL engage in the ACL-intact knee; and (2) where within the range of anterior tibial translation occurring in the ACL-sectioned knee does the ALL engage? METHODS: A robotic manipulator was used to measure anterior tibial translation, ACL forces, and ALL forces in 10 fresh-frozen cadaveric knees (10 donors; mean age, 41 ± 16 years; range, 20-64 years; eight male) in response to applied multiplanar torques...
May 5, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28475498/dimensional-changes-of-fresh-sockets-with-reactive-soft-tissue-preservation-a-cone-beam-ct-study
#16
Roberto Crespi, Paolo Capparé, Giovanni Crespi, Giorgio Gastaldi, Enrico Felice Gherlone
PURPOSE: The aim of this study was to assess dimensional changes of the fresh sockets grafted with collagen sheets and maintenance of reactive soft tissue, using cone beam computed tomography (CBCT). MATERIALS AND METHODS: Tooth extractions were performed with maximum preservation of the alveolar housing, reactive soft tissue was left into the sockets and collagen sheets filled bone defects. Cone beam computed tomography were performed before and 3 months after extractions...
May 3, 2017: Implant Dentistry
https://www.readbyqxmd.com/read/28464040/pulsed-lavage-cleansing-of-osteochondral-grafts-depends-on-lavage-duration-flow-intensity-and-graft-storage-condition
#17
Yang Sun, Weibo Jiang, Esther Cory, Jason P Caffrey, Felix H Hsu, Albert C Chen, Jincheng Wang, Robert L Sah, William D Bugbee
INTRODUCTION: Osteochondral allograft (OCA) transplantation is generally effective for treating large cartilage lesions. Cleansing OCA subchondral bone to remove donor marrow elements is typically performed with pulsed lavage. However, the effects of clinical and experimental parameters on OCA marrow removal by pulsed lavage are unknown. The aim of the current study was to determine the effects on marrow cleansing in human osteochondral cores (OCs) of (1) lavage duration, (2) lavage flow intensity, and (3) OC sample type and storage condition...
2017: PloS One
https://www.readbyqxmd.com/read/28461922/bone-grafts-bone-graft-extenders-substitutes-and-enhancers-for-acetabular-reconstruction-in-revision-total-hip-arthroplasty
#18
REVIEW
Luca Pierannunzii, Luigi Zagra
Acetabular bone loss is a relevant concern for surgeons dealing with a failed total hip arthroplasty.Since the femoral head is no longer available, allografts represent the first choice for most reconstructive solutions, either as a structural buttress or impacted bone chips.Even though fresh-frozen bone is firmly recommended for structural grafts, freeze-dried and/or irradiated bone may be used alternatively for impaction grafting. Indeed, there are some papers on freeze-dried or irradiated bone impaction grafting, but their number is limited, as is the number of cases...
December 2016: EFORT Open Rev
https://www.readbyqxmd.com/read/28460573/biomechanical-analysis-of-suture-anchor-vs-tenodesis-screw-for-fhl-transfer
#19
Mark C Drakos, Michael Gott, Sydney C Karnovsky, Conor I Murphy, Bridget A DeSandis, Noah Chinitz, Daniel Grande, Nadeen Chahine
BACKGROUND: Chronic Achilles injury is often treated with flexor hallucis longus (FHL) tendon transfer to the calcaneus using 1 or 2 incisions. A single incision avoids the risks of extended dissections yet yields smaller grafts, which may limit fixation options. We investigated the required length of FHL autograft and biomechanical profiles for suture anchor and biotenodesis screw fixation. METHODS: Single-incision FHL transfer with suture anchor or biotenodesis screw fixation to the calcaneus was performed on 20 fresh cadaveric specimens...
April 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28457420/atrophic-maxilla-reconstruction-with-fresh-frozen-allograft-bone-titanium-mesh-and-platelet-rich-fibrin-case-report
#20
R C F Baldan, F L Coracin, L Lins, W R Mello, P S Santos
The purpose of this article was to report the clinical and radiographic findings about a case of a man affected by severely atrophic maxilla to demonstrate the clinical proceedings associated with alveolar reconstruction destined for dental implant rehabilitation. The 3-dimensional augmentation of the alveolar ridge with the use of fresh-frozen bone graft, platelet-rich fibrin membrane, and titanium mesh suggests potential benefits to the development of the bone formation physiology. The treatment combination may result in an optimal prognosis and represents an option for reconstruction of bone defects...
May 2017: Transplantation Proceedings
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