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https://www.readbyqxmd.com/read/28731960/perceived-pain-extent-is-not-associated-with-widespread-pressure-pain-sensitivity-clinical-features-related-disability-anxiety-or-depression-in-women-with-episodic-migraine
#1
Cesar Fernández-de-Las-Peñas, Deborah Falla, María Palacios-Ceña, Stella Fuensalidad-Novo, Jose L Arias-Buría, Alessandro Schneebeli, Lars Arend-Nielsen, Marco Barbero
OBJECTIVE: People with migraine present with varying pain extent and an expanded distribution of perceived pain may reflect central sensitization. The relationship between pain extent and clinical features, psychological outcomes, related-disability and pressure pain sensitivity in migraine has been poorly investigated. Our aim was to investigate whether the perceived pain extent, assessed from pain drawings, relates to measures of pressure pain sensitivity, clinical, psychological outcomes, and related-disability in women with episodic migraine...
July 20, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28726265/how-to-havest-the-greatest-length-of-tibialis-posterior-tendon-in-tibialis-posterior-tendon-transfer-a-cadaveric-study
#2
Korakot Thamphongsri, Thos Harnroongroj, Atthakorn Jarusriwanna, Bavornrit Chuckpaiwong
INTRODUCTION: In anterior transfer of the tibialis posterior tendon, the tendon was harvested using two incisions, the first at its attachment point on the navicular bone and second on the medial side of the leg above the medial malleolus. To provide the maximum tendon length, the second incision needs to be as proximal as possible but injury to the muscle origin must be avoided. The purpose of this study is to establish the location of the second incision that yields the greatest tendon length...
July 20, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/28725215/prolyl-hydroxylase-domain-2-inhibition-improves-skeletal-muscle-regeneration-in-a-male-murine-model-of-obesity
#3
Indranil Sinha, Dharaniya Sakthivel, Benjamin A Olenchock, Carla R Kruse, Jeremy Williams, David E Varon, Jessica D Smith, Arin L Madenci, Kristo Nuutila, Amy J Wagers
Obesity leads to a loss of muscle mass and impaired muscle regeneration. In obese individuals, pathologically elevated levels of prolyl hydroxylase domain enzyme 2 (PHD2) limit skeletal muscle hypoxia-inducible factor-1 alpha and vascular endothelial growth factor (VEGF) expression. Loss of local VEGF may further impair skeletal muscle regeneration. We hypothesized that PHD2 inhibition would restore vigorous muscle regeneration in a murine model of obesity. Adult (22-week-old) male mice were fed either a high-fat diet (HFD), with 60% of calories derived from fat, or a regular diet (RD), with 10% of calories derived from fat, for 16 weeks...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28720584/protein-kinase-n2-regulates-amp-kinase-signaling-and-insulin-responsiveness-of-glucose-metabolism-in-skeletal-muscle
#4
Maxwell A Ruby, Isabelle Riedl, Julie Massart, Marcus Åhlin, Juleen R Zierath
Insulin resistance is central to the development of type 2 diabetes and related metabolic disorders. As skeletal muscle is responsible for the majority of whole body insulin-stimulated glucose uptake, regulation of glucose metabolism in this tissue is of particular importance. While Rho GTPases and many of their affecters influence skeletal muscle metabolism, there is a paucity of information on the protein kinase N (PKN) family of serine/threonine protein kinases. We investigated the impact of PKN2 on insulin signaling and glucose metabolism in primary human skeletal muscle cells in vitro and mouse tibialis anterior muscle in vivo...
July 18, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28717665/identification-of-an-alu-element-mediated-deletion-in-the-promoter-region-of-gne-in-siblings-with-gne-myopathy
#5
Jennifer Garland, Joshi Stephen, Bradley Class, Angela Gruber, Carla Ciccone, Aaron Poliak, Christina P Hayes, Vandana Singhal, Christina Slota, John Perreault, Ralitza Gavrilova, Joseph A Shrader, Prashant Chittiboina, Galen Joe, John Heiss, William A Gahl, Marjan Huizing, Nuria Carrillo, May Christine V Malicdan
BACKGROUND: GNE myopathy is a rare genetic disease characterized by progressive muscle atrophy and weakness. It is caused by biallelic mutations in the GNE gene that encodes for the bifunctional enzyme, uridine diphosphate (UDP)-N-acetylglucosamine (GlcNAc) 2-epimerase/N-acetylmannosamine (ManNAc) kinase. Typical characteristics of GNE myopathy include progressive myopathy, first involving anterior tibialis muscle and sparing the quadriceps, and rimmed vacuoles on muscle biopsy. Identifying biallelic mutations by sequencing of the GNE gene confirms the diagnosis of GNE myopathy...
July 2017: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/28712265/jaeumganghwa-tang-a-traditional-herbal-formula-improves-muscle-function-and-attenuates-muscle-loss-in-aged-mice
#6
Yun Mi Lee, Ohn Soon Kim
PURPOSE: Jaeumganghwa-Tang (JGT), a traditional herbal formula composed of 12 medicinal herbs, is used for the treatment of age-related diseases. In the present study, we investigated the effects of JGT on muscle mass and function in aged mice. METHODS: Young (5-month-old) and old (19-month-old) male C57BL/6 mice were divided into two groups each; one group received JGT (75 mg/d) and the other group received the vehicle for 6 weeks. At the end of the experimental period, muscle strength was examined using the wire hang test, and the tibialis anterior and gastrocnemius muscles were weighed...
March 31, 2017: Journal of Exercise Nutrition & Biochemistry
https://www.readbyqxmd.com/read/28710329/open-label-trial-of-ranolazine-for-the-treatment-of-myotonia-congenita
#7
W David Arnold, David Kline, Alan Sanderson, Ahmed A Hawash, Amy Bartlett, Kevin R Novak, Mark M Rich, John T Kissel
OBJECTIVE: To determine open-label, pilot study whether ranolazine could improve signs and symptoms of myotonia and muscle stiffness in patients with myotonia congenita (MC). METHODS: Thirteen participants were assessed at baseline and 2, 4, and 5 weeks. Ranolazine was started after baseline assessment (500 mg twice daily), increased as tolerated after week 2 (1,000 mg twice daily), and maintained until week 4. Outcomes included change from baseline to week 4 in self-reported severity of symptoms (stiffness, weakness, and pain), Timed Up and Go (TUG), hand grip and eyelid myotonia, and myotonia on EMG...
July 14, 2017: Neurology
https://www.readbyqxmd.com/read/28702442/kinematics-and-neuromuscular-recruitment-during-vertical-treadmill-exercise
#8
Alastair R Jordan, Andrew Barnes, David Claxton, Alison Purvis, Mary Fysh
The vertical treadmill (VertiRun) is an unresearched, partial weight-bearing exercise mode for lower limb rehabilitation. The user undertakes a "running-like" action whilst body weight is supported by a bench and the limb is drawn downwards against overhanging resistance cables on a vertically hung nonmotorised treadmill. This study sought to describe the kinematics and neuromuscular recruitment during VertiRun exercise in the supine, 40°, and 70° postures. Twenty-one healthy male participants (age, 25±7 years; stature, 1...
June 2017: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/28701544/modulation-of-corticospinal-input-to-the-legs-by-arm-and-leg-cycling-in-people-with-incomplete-spinal-cord-injury
#9
Rui Zhou, Laura Alvarado, Seoyoung Kim, Su Ling Chong, Vivian K Mushahwar
The spinal cervico-lumbar interaction during rhythmic movements in humans has recently been studied; however, the role of arm movements in modulating the corticospinal drive to the legs is not well understood. The goals of this study were to investigate the effect of active rhythmic arm movements on the corticospinal drive to the legs (study 1); and assess the effect of simultaneous arm and leg training on the corticospinal pathway after incomplete spinal cord injury (iSCI) (study 2). In study 1, neurologically intact (NI) participants or participants with iSCI performed combinations of stationary and rhythmic cycling of the arms and legs, while motor evoked potentials (MEPs) were recorded from the vastus lateralis (VL) muscle...
July 12, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28696371/biocompatibility-of-four-common-orthopedic-biomaterials-following-a-high-salt-diet-an-in-vivo-study
#10
Mathieu Lecocq, Cécile Bernard, Marie Solenne Felix, Jean-Marc Linares, Julien Chaves-Jacob, Patrick Decherchi, Erick Dousset
Nowadays, salt consumption appears to be drastically above the recommended level in industrialized countries. The health consequences of this overconsumption are heavy since high-salt intake induces cardiovascular disease, kidney dysfunction, and stroke. Moreover, harmful interaction may also occur with orthopaedic devices because overconsumption of salt reinforces the corrosive aspect of biological tissues and favors bone resorption process. In the present study, we aimed to assess the in vivo effect of three weeks of a high-salt diet, associated (or not) with two weeks of the neuro-myoelectrostimulation (NMES) rehabilitation program on the biocompatibility of four biomaterials used in the manufacture of arthroplasty implants...
July 11, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28690008/laminin-mimetic-peptide-nanofibers-regenerate-acute-muscle-defect
#11
Cagla Eren Cimenci, Gozde Uzunalli, Ozge Uysal, Fatih Yergoz, Ebru Karaca Umay, Mustafa O Guler, Ayse B Tekinay
Skeletal muscle cells are terminally differentiated and require the activation of muscle progenitor (satellite) cells for their regeneration. There is a clinical need for faster and more efficient treatment methods for acute muscle injuries, and the stimulation of satellite cell proliferation is promising in this context. In this study, we designed and synthesized a laminin-mimetic bioactive peptide (LM/E-PA) system that is capable of accelerating satellite cell activation by emulating the structure and function of laminin, a major protein of the basal membrane of the skeletal muscle...
July 8, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28688293/a-new-parameter-for-quantifying-the-variability-of-surface-electromyographic-signals-during-gait-the-occurrence-frequency
#12
Francesco Di Nardo, Alessandro Mengarelli, Annachiara Strazza, Valentina Agostini, Marco Knaflitz, Laura Burattini, Sandro Fioretti
Natural variability of myoelectric activity during walking was recently analyzed considering hundreds of strides. This allowed assessing a parameter seldom considered in classic surface EMG (sEMG) studies: the occurrence frequency, defined as the frequency each muscle activation occurs with, quantified by the number of strides when a muscle is recruited with that specific activation modality. Aim of present study was to propose the occurrence frequency as a new parameter for assessing sEMG-signal variability during walking...
June 30, 2017: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/28685425/multi-site-measurements-of-muscle-o2-dynamics-during-cycling-exercise-in-early-post-myocardial-infarction
#13
Shun Takagi, Ryotaro Kime, Norio Murase, Masatsugu Niwayama, Takuya Osada, Toshihito Katsumura
The aim of this study was to compare the muscle oxygen dynamics between early post-myocardial infarction (n = 12; MI) and age-matched elderly subjects without MI (n = 12; CON) in several leg muscles during ramp cycling exercise. Muscle oxygen saturation (SmO2), deoxygenated-hemoglobin concentration (∆deoxy-Hb), and total-hemoglobin concentration (∆total-Hb) were monitored continuously at the distal site of vastus lateralis (VLd), proximal site of the vastus lateralis (VLp), rectus femoris (RF), vastus medialis (VM), gastrocnemius medialis (GM), and tibialis anterior (TA) muscles by near infrared spatial resolved spectroscopy...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28685423/dorsiflexor-muscle-oxygenation-during-low-moderate-and-submaximal-sustained-isometric-contraction
#14
Adkham Paiziev, Martin Wolf, Fikrat Kerimov
Sustained isometric contractions of skeletal muscles produce intramuscular pressures that lead to blood flow restriction. Thus, we have the paradox of rising O2 demand due to muscle activity and at the same time reduced blood flow. The aim was to assess muscle oxygenation during sustained isometric low (30%), moderate (60%) and submaximal [90% of maximal voluntary contraction (MVC)] contraction of the dorsiflexor muscle. Experiments were conducted on the dominant (right) leg of 8 male students (age 19 ± 2 years, weight 75 ± 6 kg)...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28682935/muscle-activity-and-physiological-responses-during-running-in-water-and-on-dry-land-at-submaximal-and-maximal-efforts
#15
Kenji Masumoto, Kyle C Mefferd, Riley Iyo, John A Mercer
We investigated muscle activity, oxygen uptake, heart rate, and rating of perceived exertion during running in water and on dry land at submaximal and maximal efforts. Eleven recreational runners performed deep water running (DWR) and treadmill running (TMR) graded exercise tests on separate days. On the third test day, the participants exercised at their 60%, 80%, and 100% of maximal oxygen uptake (VO2max) by matching specific stride frequencies or running speeds. VO2max, maximal heart rate (HRmax), and rating of perceived exertion at maximal effort (RPEmax) were measured...
July 3, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28678060/association-between-clinical-and-neurophysiological-outcomes-in-patients-with-mechanical-neck-pain-and-whiplash-associated-disorders
#16
Matteo Castaldo, Antonella Catena, Alessandro Chiarotto, Jorge Hugo Villafañe, César Fernández-de-Las-Peñas, Lars Arendt-Nielsen
OBJECTIVES: To investigate the association between pain, disability, trigger points (TrPs) and pressure pain thresholds (PPTs) in patients with mechanical (MNP) or whiplash-associated disorders (WAD). METHODS: Forty-six MNP and fifty-one WAD patients underwent a physical examination consisting of cervical range of motion, PPTs in the upper trapezius and tibialis anterior muscles, TrPs examination in the upper trapezius, and collection of clinical data including disability, pain intensity and spontaneous symptomatic pain area...
July 3, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28678054/exercise-training-prevents-dexamethasone-induced-rarefaction
#17
Naiara A Herrera, Isley Jesus, Evandro J Dionísio, Thiago J Dionísio, Carlos F Santos, Sandra L Amaral
Dexamethasone (DEX) causes rarefaction. In contrast, training (T) prevents rarefaction and stimulates angiogenesis. This study investigated the mechanisms responsible for the preventive role of T in DEX-induced rarefaction. Rats underwent T or were kept sedentary (8 weeks) and were treated with DEX or saline during the following 14 days. Tibialis anterior (TA) muscle was used for measurements of capillary density (CD), capillary-to-fiber ratio (C:F ratio), superoxide dismutase CuZn (SOD-1), superoxide dismutase MnSOD (SOD-2), catalase (CAT) mRNA as well as SOD-1, SOD-2, CAT, vascular endothelial growth factor (VEGF), vascular endothelial growth factor receptor-2 (VEGF-R2), cyclooxygenase-2 (COX-2), B-cell lymphoma 2 (Bcl-2), bcl-2-like protein 4 (Bax), p-Bax and caspase-3 cleaved protein levels...
May 17, 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/28673716/contribution-of-the-supplementary-motor-area-and-the-cerebellum-to-the-anticipatory-postural-adjustments-and-execution-phases-of-human-gait-initiation
#18
Aliénor Richard, Angèle Van Hamme, Xavier Drevelle, Jean-Louis Golmard, Sabine Meunier, Marie-Laure Welter
Several brain structures including the brainstem, the cerebellum and the frontal cortico-basal ganglia network, with the primary and premotor areas have been shown to participate in the functional organization of gait initiation and postural control in humans, but their respective roles remain poorly understood. The aim of this study was to better understand the role of the supplementary motor area (SMA) and posterior cerebellum in the gait initiation process. Gait initiation parameters were recorded in 22 controls both before and after continuous theta burst transcranial stimulation (cTBS) of the SMA and cerebellum, and were compared to sham stimulation, using a randomized double-blind design study...
July 1, 2017: Neuroscience
https://www.readbyqxmd.com/read/28667314/evaluation-of-muscular-changes-by-ultrasound-nakagami-imaging-in-duchenne-muscular-dystrophy
#19
Wen-Chin Weng, Po-Hsiang Tsui, Chia-Wei Lin, Chun-Hao Lu, Chun-Yen Lin, Jeng-Yi Shieh, Frank Leigh Lu, Ting-Wei Ee, Kuan-Wen Wu, Wang-Tso Lee
Duchenne muscular dystrophy (DMD) is the most common debilitating muscular disorder. Developing a noninvasive measure for monitoring the progression of this disease is critical. The present study tested the effectiveness of using ultrasound Nakagami imaging to evaluate the severity of the dystrophic process. A total of 47 participants (40 with DMD and 7 healthy controls) were recruited. Patients were classified into stage 1 (presymptomatic and ambulatory), stage 2 (early nonambulatory), and stage 3 (late nonambulatory)...
June 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28660212/anatomical-footprint-of-the-tibialis-anterior-tendon-surgical-implications-for-foot-and-ankle-reconstructions
#20
Madeleine Willegger, Nargiz Seyidova, Reinhard Schuh, Reinhard Windhager, Lena Hirtler
This study aimed to analyze precisely the dimensions, shapes, and variations of the insertional footprints of the tibialis anterior tendon (TAT) at the medial cuneiform (MC) and first metatarsal (MT1) base. Forty-one formalin-fixed human cadaveric specimens were dissected. After preparation of the TAT footprint, standardized photographs were made and the following parameters were evaluated: the footprint length, width, area of insertion, dorsoplantar location, shape, and additional tendon slips. Twenty feet (48...
2017: BioMed Research International
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