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Jodi Walters, Shawn Cazzell, Hau Pham, Dean Vayser, Alexander Reyzelman
OBJECTIVE: The purpose of this 16-week, multicenter, randomized, controlled trial was to assess the healed ulcer rate of a human acellular dermal matrix, DermACELL, compared with conventional care and a second acellular dermal matrix, Graftjacket, in the treatment of full-thickness diabetic foot ulcers. METHODS: One hundred sixty-eight patients were randomized into DermACELL, conventional care, and Graftjacket treatment arms in a 2:2:1 ratio. Patients in the acellular dermal matrix groups received either 1 or 2 applications of the graft at the discretion of the investigator...
2016: Eplasty
R D Smith, A Carr, S G Dakin, S J Snelling, C Yapp, O Hakimi
Surgical repairs of rotator cuff tears have high re-tear rates and many scaffolds have been developed to augment the repair. Understanding the interaction between patients' cells and scaffolds is important for improving scaffold performance and tendon healing. In this in vitro study, we investigated the response of patient-derived tenocytes to eight different scaffolds. Tested scaffolds included X-Repair, Poly-Tape, LARS Ligament, BioFiber (synthetic scaffolds), BioFiber-CM (biosynthetic scaffold), GraftJacket, Permacol, and Conexa (biological scaffolds)...
2016: European Cells & Materials
R D Smith, A Carr, S G Dakin, S J Snelling, C Yapp, O Hakimi
Surgical repairs of rotator cuff tears have high re-tear rates and many scaffolds have been developed to augment the repair. Understanding the interaction between patients' cells and scaffolds is important for improving scaffold performance and tendon healing. In this in vitro study, we investigated the response of patient-derived tenocytes to eight different scaffolds. Tested scaffolds included X-Repair, Poly-Tape, LARS Ligament, BioFiber (synthetic scaffolds), BioFiber-CM (biosynthetic scaffold), GraftJacket, Permacol, and Conexa (biological scaffolds)...
2016: European Cells & Materials
Gabor J Puskas, Dominik C Meyer, Julia A Lebschi, Christian Gerber
BACKGROUND: Treatment of glenohumeral osteoarthritis in young patients is challenging. Total shoulder arthroplasty reliably addresses pain and dysfunction but compromises glenoid bone stock. Various efforts have been made to avoid a prosthetic glenoid component or to prevent glenoid erosion after hemiarthroplasty. Capsular interposition, meniscal allograft, and more recently, GraftJacket (Wright Medical Technology Inc, Arlington, TN, USA), a human dermal collagen allograft, have been proposed for interposition arthroplasty in young patients with glenohumeral osteoarthritis...
December 2015: Journal of Shoulder and Elbow Surgery
Robert M Parks, Stephanie M Parks
BACKGROUND: We describe a retrospective study that uses the Broström-type surgical procedure with modifications that augment deficient and torn ligaments with acellular human dermal grafts. At the onset of this study, the most prevalent dermal graft available to us was GraftJacket (Wright Medical Technology, Arlington, Tennessee). Greater than 50% of the study participants were grafted with this product, but more recently other equally effective human dermal grafts have been used with no apparent difference...
May 2015: Journal of the American Podiatric Medical Association
Tyson K Cobb, Anna L Walden, Ying Cao
PURPOSE: To report results on 144 cases following arthroscopic resection arthroplasty (ARA) with or without interposition for basal joint arthritis. METHODS: Cases undergoing ARA for thumb carpometacarpal osteoarthritis between 2004 and 2011 were prospectively enrolled (n = 178). Data were collected before surgery and after surgery at 1, 3, 6, and 12 months and annually thereafter. Patients were excluded for less than 1-year follow-up or concomitant procedures that interfered with evaluation of the variable of interest (interposition)...
September 2015: Journal of Hand Surgery
M L Williams, J E Holewinski
OBJECTIVE: Rising prevalence of obesity and uncontrolled diabetes mellitus has resulted in an increasing number of patients with multiple comorbidities who require treatment for chronic complex wounds. Because patients with diabetes and foot ulcers may have a higher risk for amputations, techniques that facilitate complex wound healing and prevent limb amputation are desirable. Here, we investigate a limb preservation strategy that includes application of a human acellular dermal wound matrix (HADWM)...
June 2015: Journal of Wound Care
A M Reyzelman, I Bazarov
UNLABELLED: Diabetic foot ulcers (DFUs) affect a significant number of people and the treatment is challenging and costly. Since only a small portion of patients respond to standard care, the majority require more advanced wound healing interventions. Human acellular dermal matrices-regenerative tissue matrices derived from human tissue and processed from screened donated skin-can aid wound closure by restoring the missing physiological factors to the microenvironment. A literature review of the clinical literature was performed to estimate the comparative effectiveness of one specific human acellular dermal wound matrix (HADWM; Graftjacket regenerative tissue matrix) versus standard care in healing DFUs...
March 2015: Journal of Wound Care
Robert S Kirsner, Greg Bohn, Vickie R Driver, Joseph L Mills, Lillian B Nanney, Marie L Williams, Stephanie C Wu
A chronic wound fails to complete an orderly and timely reparative process and places patients at increased risk for wound complications that negatively impact quality of life and require greater health care expenditure. The role of extracellular matrix (ECM) is critical in normal and chronic wound repair. Not only is ECM the largest component of the dermal skin layer, but also ECM proteins provide structure and cell signalling that are necessary for successful tissue repair. Chronic wounds are characterised by their inflammatory and proteolytic environment, which degrades the ECM...
December 2015: International Wound Journal
Surena Namdari, Christopher Melnic, G Russell Huffman
BACKGROUND: Biologic glenoid resurfacing is a treatment option for young patients with glenohumeral arthritis. An optimal synthetic graft for glenoid resurfacing should allow repopulation with host cells, be durable enough to tolerate suture fixation and forces across the joint, and present no host inflammatory response. We report two cases of giant cell reaction to GraftJacket(®) after biologic glenoid resurfacing. CASE DESCRIPTION: Two patients who underwent hemiarthroplasty and biologic glenoid resurfacing using GraftJacket(®) had a foreign body giant cell reaction that required revision surgery...
August 2013: Clinical Orthopaedics and related Research
Wissam E Khoury, Ramy Fahim, Jessica M Sciulli, Duane J Ehredt
Management of failed first metatarsophalangeal joint implant arthroplasty, especially in the face of infection, is an area of debate without a clear consensus. The purpose of the present report was to explore a new option of reconstructing the joint with an acellular dermal matrix substance in a single case study during a 12-month follow-up period. A staged approach that began with removal of the failed 2-component great toe implant, Koenig(®), excisional debridement of the wound with resection of the necrotic bone (proximal phalanx and distal portion of the first metatarsal bones), and culture-specific antibiosis therapy...
September 2012: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
Hiromichi Omae, Scott P Steinmann, Chunfeng Zhao, Mark E Zobitz, Prasit Wongtriratanachai, John W Sperling, Kai-Nan An
BACKGROUND: Acellular human dermal matrix grafts (Graftjacket; Wright Medical Technology, Arlington, TN, USA) are used clinically for rotator cuff augmentation without a detailed understanding of their biomechanical effects. The purpose of this study was to evaluate the effect of augmentation with dermal grafts on the biomechanical effects of rotator cuff repairs. METHODS: Nine matched pairs of human cadaveric shoulders were used. A single-row rotator cuff repair combined with an augmentation graft was performed on one shoulder, and a single-row repair was performed on the contralateral shoulder as a control...
October 2012: Clinical Biomechanics
N Papanas, I Eleftheriadou, N Tentolouris, E Maltezos
The diabetic foot remains a major cause of morbidity worldwide. Even though considerable progress has been achieved over the past years, there is still an urgent need for improvement. While established therapeutic modalities (revascularization, casting and debridement) remain the mainstay of management, there is, therefore, continuous development of new treatment options. This review provides an outlook of advances in topical treatment, including bioengineered skin substitutes (such as Dermagraft, Apligraf, HYAFF, OASIS and Graftjacket), extracellular matrix proteins (such as Hyalofill and E-matrix), as well as miscellaneous further therapeutic adjuncts...
May 2012: Current Diabetes Reviews
Jarema S Czarnecki, Khalid Lafdi, Robert M Joseph, Panagiotis A Tsonis
Current biomedical scaffolds utilized in surgery to repair soft tissues commonly fail to meet the optimal combination of biomechanical and tissue regenerative properties. Carbon is a scaffold alternative that potentially optimizes the balance between mechanical strength, durability, and function as a cell and biologics delivery vehicle that is necessary to restore tissue function while promoting tissue repair. The goals of this study were to investigate the feasibility of fabricating hybrid fibrous carbon scaffolds modified with biopolymer, polycaprolactone and to analyze their mechanical properties and ability to support cell growth and proliferation...
May 2012: Tissue Engineering. Part A
Salma Chaudhury, Chris Holland, Mark S Thompson, Fritz Vollrath, Andrew J Carr
BACKGROUND: Augmentation of rotator cuff tears aims to strengthen the repair and reduce rerupture, yet studies still report high failure rates. This study determines key mechanical properties of rotator cuff repair patches, including establishing values for toughness and measuring the shear properties of repair patches and human rotator cuff tendons. We hypothesized that different repair grafts would (1) have varying material parameters, and (2) not all have mechanical properties similar to human rotator cuff tendons...
September 2012: Journal of Shoulder and Elbow Surgery
F Alan Barber, Joseph P Burns, Allen Deutsch, Marc R Labbé, Robert B Litchfield
PURPOSE: To prospectively evaluate the safety and effectiveness of arthroscopic acellular human dermal matrix augmentation of large rotator cuff tear repairs. METHODS: A prospective, institutional review board-approved, multicenter series of patients undergoing arthroscopic repair of 2-tendon rotator cuff tears measuring greater than 3 cm were randomized by sealed envelopes opened at the time of surgery to arthroscopic single-row rotator cuff repair with GraftJacket acellular human dermal matrix (Wright Medical Technology, Arlington, TN) augmentation (group 1) or without augmentation (group 2)...
January 2012: Arthroscopy: the Journal of Arthroscopic & related Surgery
Lin Song, Raymond E Olsen, Jeffrey P Spalazzi, Twana Davisson
The rate of rerupture of repaired Achilles tendon in young and athletic populations remains high despite improvement in surgical techniques, suture design, and postsurgical management. Acellular biological matrices can be used to enhance the immediate strength of repaired tendons and to serve as scaffolds for cell in-growth and constructive tissue remodeling. A number of commercially available matrices have been used clinically, albeit with varying degrees of success and failure. The disparity is likely attributable to the different physical and biochemical properties of individual matrices...
September 2010: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
Ivan Wong, Joseph Burns, Stephen Snyder
HYPOTHESIS: Management of massive, degenerative, and irreparable rotator cuff tears is challenging. Excessive re-tear rates and poor clinical outcome after standard repair have led to alternative methods of treatment. Tendon transfers and shoulder arthroplasty have had mixed results; both are invasive procedures with high potential morbidity. We began performing rotator cuff augmentation and replacement using GraftJacket allograft acellular human dermal matrix as a biologic minimally invasive alternative in this difficult population almost 6 years ago...
March 2010: Journal of Shoulder and Elbow Surgery
F Alan Barber, Jorge Aziz-Jacobo
PURPOSE: To evaluate several physical properties and physical dimensions of commercially available soft-tissue augmentation devices. METHODS: After 2 x 5-cm strips of several graft materials were hydrated, load elongation, cyclic and permanent displacement, percent elastic displacement, tensile modulus, stiffness, and ultimate load-to-failure strength were determined. With a 5-N preload, 30 cyclic loads between 5 N and 50 N were applied at 12.5 mm/s followed by destructive testing...
November 2009: Arthroscopy: the Journal of Arthroscopic & related Surgery
Stephen A Brigido, Edward Schwartz, Raymond McCarroll, Janet Hardin-Young
A novel injectable human dermal matrix has been developed for the treatment of complex diabetic sinus tract wounds. Bioengineered grafts are commercially available that have been somewhat effective in treating chronic wounds such as diabetic foot ulcers; however, these bioengineered grafts are only available in sheet form. These therapies are less effective in treating complex or irregularly shaped wounds that demonstrate tunnels or extensions into deep soft tissue. One acellular graft (GRAFTJACKET, Matrix, Wright Medical Technology, Arlington, Tennessee) that has been shown to effectively treat open wounds is also available in a micronized form (GRAFTJACKET Xpress Scaffold, Wright Medical Technology)...
April 2009: Foot & Ankle Specialist
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