keyword
MENU ▼
Read by QxMD icon Read
search

Impaired glucose tolerance. Hba1c

keyword
https://www.readbyqxmd.com/read/28203358/the-renal-effects-of-sglt2-inhibitors-and-a-mini-review-of-the-literature
#1
REVIEW
Vasileios Andrianesis, Spyridoula Glykofridi, John Doupis
Sodium-glucose linked transporter 2 (SGLT2) inhibitors are a new and promising class of antidiabetic agents which target renal tubular glucose reabsorption. Their action is based on the blockage of SGLT2 sodium-glucose cotransporters that are located at the luminal membrane of tubular cells of the proximal convoluted tubule, inducing glucosuria. It has been proven that they significantly reduce glycated hemoglobin (HbA1c), along with fasting and postprandial plasma glucose in patients with type 2 diabetes mellitus (T2DM)...
December 2016: Therapeutic Advances in Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28178143/healthy-lifestyle-and-normal-waist-circumference-are-associated-with-a-lower-5-year-risk-of-type-2-diabetes-in-middle-aged-and-elderly-individuals-results-from-the-healthy-aging-longitudinal-study-in-taiwan-halst
#2
Chu-Chih Chen, Kiang Liu, Chih-Chen Hsu, Hsing-Yi Chang, Hsiao-Chun Chung, Jih-Shin Liu, Yo-Hann Liu, Tsung-Lung Tsai, Wen-Jin Liaw, I-Ching Lin, Hsi-Wen Wu, Chung-Chou Juan, Hou-Chang Chiu, Marion M Lee, Chao A Hsiung
Type 2 diabetes mellitus (DM) is known to be closely associated with lifestyle and obesity and has a prevalence that increases with age. This study aimed to assess the short-term composite effect of diet, physical activity, psychosocial health, and waist circumference (WC) on the incidence of DM in the elderly and to provide a lifestyle-based predictive index.We used baseline measurements (2009-2013) of 5349 community-dwelling participants (aged 55 years and older, 52% female) of the Healthy Aging Longitudinal Study in Taiwan (HALST) for fasting plasma glucose, HbA1C, serum cholesterol, triglycerides, blood pressures, WC, and outcomes of home-visit questionnaire...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28123936/metabolomic-profiling-identifies-potential-pathways-involved-in-the-interaction-of-iron-homeostasis-with-glucose-metabolism
#3
Lars Stechemesser, Sebastian K Eder, Andrej Wagner, Wolfgang Patsch, Alexandra Feldman, Michael Strasser, Simon Auer, David Niederseer, Ursula Huber-Schönauer, Bernhard Paulweber, Stephan Zandanell, Sandra Ruhaltinger, Daniel Weghuber, Elisabeth Haschke-Becher, Christoph Grabmer, Eva Rohde, Christian Datz, Thomas K Felder, Elmar Aigner
OBJECTIVE: Elevated serum ferritin has been linked to type 2 diabetes (T2D) and adverse health outcomes in subjects with the Metabolic Syndrome (MetS). As the mechanisms underlying the negative impact of excess iron have so far remained elusive, we aimed to identify potential links between iron homeostasis and metabolic pathways. METHODS: In a cross-sectional study, data were obtained from 163 patients, allocated to one of three groups: (1) lean, healthy controls (n = 53), (2) MetS without hyperferritinemia (n = 54) and (3) MetS with hyperferritinemia (n = 56)...
January 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/28120261/atorvastatin-decreased-circulating-rantes-levels-in-impaired-glucose-tolerance-patients-with-hypercholesterolemia-an-interventional-study
#4
Xiaomeng Feng, Xia Gao, Yumei Jia, Heng Zhang, Yuan Xu
INTRODUCTION: Impaired glucose tolerance (IGT) is the major cause of the development of both type 2 diabetes and atherosclerosis. Regulated upon activation, normal T cells expressed and secreted (RANTES), a proinflammatory chemokine, is associated with atherosclerosis. We investigated the effect of atorvastatin on circulating RANTES in IGT patients with hypercholesterolemia. METHODS: This study evaluated cross-sectional and interventional studies of 32 IGT patients with hypercholesterolemia (group A) and 32 controls (group B)...
January 24, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/28097367/impaired-glucose-homeostasis-in-first-episode-schizophrenia-a-systematic-review-and-meta-analysis
#5
Toby Pillinger, Katherine Beck, Cristian Gobjila, Jacek G Donocik, Sameer Jauhar, Oliver D Howes
Importance: Schizophrenia is associated with an increased risk of type 2 diabetes. However, it is not clear whether schizophrenia confers an inherent risk for glucose dysregulation in the absence of the effects of chronic illness and long-term treatment. Objective: To conduct a meta-analysis examining whether individuals with first-episode schizophrenia already exhibit alterations in glucose homeostasis compared with controls. Data Sources: The EMBASE, MEDLINE, and PsycINFO databases were systematically searched for studies examining measures of glucose homeostasis in antipsychotic-naive individuals with first-episode schizophrenia compared with individuals serving as controls...
January 11, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28073124/the-effects-of-blood-glucose-regulation-in-omentin-1-levels-among-diabetic-patients
#6
Yucel Arman, Kerem Kirna, Bilal Ugurlukisi, Orkide Kutlu, Okan Dikker, Eylem Ozgun Cil, Murat Akarsu, Mustafa Ozcan, Gulden Yuruyen, Pinar Demir, Ozgur Altun, Ekmel Burak Ozsenel, Mustafa Genco Erdem, Riza Sandikci, Tufan Tukek
Objectives: Omentin-1, an adipocytokine that increases the insulin sensitivity, has been determined to be reduced in patients with insulin resistance, impaired glucose tolerance, and Type-2 diabetes mellitus. In this study, we have investigated the alterations in Omentin-1 levels with the blood glucose regulation in diabetic patients having poor glycemic control. By this way, we aimed to determine the role of Omentin-1 as a marker in follow-up and monitoring progression of diabetes. Methods: Totally 58 patients with type 2 diabetes mellitus, older than 18 years of age who were having poor glycemic control (HbA1c≥9) were included in this study...
January 10, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28024276/effect-of-lifestyle-interventions-on-glucose-regulation-among-adults-without-impaired-glucose-tolerance-or-diabetes-a-systematic-review-and-meta-analysis
#7
REVIEW
Xuanping Zhang, Giuseppina Imperatore, William Thomas, Yiling J Cheng, Felipe Lobelo, Keri Norris, Heather M Devlin, Mohammed K Ali, Stephanie Gruss, Barbara Bardenheier, Pyone Cho, Isabel Garcia de Quevedo, Uma Mudaliar, Jinan Saaddine, Linda S Geiss, Edward W Gregg
This study systematically assessed the effectiveness of lifestyle interventions on glycemic indicators among adults (⩾18years) without IGT or diabetes. Randomized controlled trials using physical activity (PA), diet (D), or their combined strategies (PA+D) with follow-up ⩾12months were systematically searched from multiple electronic-databases between inception and May 4, 2016. Outcome measures included fasting plasma glucose (FPG), glycated hemoglobin (HbA1c), fasting insulin (FI), homeostasis model assessment-estimated insulin resistance (HOMA-IR), and bodyweight...
January 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28019072/efficacy-safety-and-albuminuria-reducing-effect-of-gemigliptin-in-korean-type-2-diabetes-patients-with-moderate-to-severe-renal-impairment-a-12-week-double-blind-randomized-study-the-guard-study
#8
Sun A Yoon, Byoung G Han, Sung G Kim, Sang Y Han, Young I Jo, Kyung H Jeong, Kook H Oh, Hyoung C Park, Sun H Park, Shin W Kang, Ki R Na, Sun W Kang, Nam H Kim, Young H Jang, Seong H Shin, Dae R Cha
AIMS: This multicentre, randomized, double-blind study investigated the efficacy and safety of gemigliptin in Korean type 2 diabetes mellitus (T2DM) patients with moderate to severe renal impairment (RI). METHODS: The study comprised a 12-week main part and a 40-week extension. We report the results from the main part. In total, 132 patients were randomized to receive gemigliptin (n = 66) or placebo (n = 66). Changes in glycated haemoglobin (HbA1c; primary endpoint), other glycaemic control parameters (fasting plasma glucose, glycated albumin, and fructosamine), lipid profiles, renal function parameters, and safety profiles were evaluated...
December 25, 2016: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/27986405/an-elevated-1-h-post-load-glucose-level-during-the-oral-glucose-tolerance-test-detects-prediabetes
#9
Martin Buysschaert, Michael Bergman, Donald Yanogo, Ram Jagannathan, Benoit Buysschaert, Vanessa Preumont
AIM: The objective of the study was to compare the diagnosis of dysglycemic states by conventional oral glucose tolerance test (OGTT) criteria (fasting and 2-h plasma glucose) with the 1-h post-load plasma glucose level. MATERIAL AND METHODS: 34 individuals (mean age: 55±13years; BMI: 27.7±6.3kg/m(2)) at risk for prediabetes were administered a 75g OGTT. Individuals with normal glucose tolerance (NGT) or prediabetes were identified according to fasting and/or 2-h plasma glucose (PG) concentrations...
December 9, 2016: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/27917464/relation-of-dysglycemia-to-structural-brain-changes-in-a-multiethnic-elderly-cohort
#10
Christiane Reitz, Vanessa A Guzman, Atul Narkhede, Charles DeCarli, Adam M Brickman, José A Luchsinger
OBJECTIVES: Abnormally high glucose levels (dysglycemia) increase with age. Epidemiological studies suggest that dysglycemia is a risk factor for cognitive impairment but the underlying pathophysiological mechanisms remain unclear. The objective of this study was to examine the relation of dysglycemia clinical categories (normal glucose tolerance (NGT), pre-diabetes, undiagnosed diabetes, known diabetes) with brain structure in older adults. We also assessed the relation between dysglycemia and cognitive performance...
February 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27894750/risk-factors-for-autonomic-and-somatic-nerve-dysfunction-in-different-stages-of-glucose-tolerance
#11
Rumyana Dimova, Tsvetalina Tankova, Velina Guergueltcheva, Ivailo Tournev, Nevena Chakarova, Greta Grozeva, Lilia Dakovska
AIM: The present study evaluates autonomic and somatic nerve function in different stages of glucose tolerance and its correlation with different cardio-metabolic parameters. MATERIAL AND METHODS: Four hundred seventy-eight subjects, mean age 49.3±13.7years and mean BMI 31.0±6.2kg/m2, divided according to glucose tolerance: 130 with normal glucose tolerance (NGT), 227 with prediabetes (125 with impaired fasting glucose (IFG) and 102 with isolated impaired glucose tolerance (iIGT)), and 121 with newly-diagnosed T2D (NDT2D), were enrolled...
November 6, 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27884155/long-chain-polyunsaturated-fatty-acids-lcpufas-and-nordihydroguaiaretic-acid-ndga-modulate-metabolic-and-inflammatory-markers-in-a-spontaneous-type-2-diabetes-mellitus-model-stillman-salgado-rats
#12
Alejandro Dain, Gaston Repossi, Gustavo T Diaz-Gerevini, Jairam Vanamala, Undurti N Das, Aldo R Eynard
BACKGROUND: Diabetes mellitus (DM) is a complex disease with alterations in metabolic and inflammatory markers. Stillman Salgado rats (eSS) spontaneously develop type 2 DM by middle age showing progressive impairment of glucose tolerance with hyperglycemia, hypertriglyceridemia and hyperinsulinemia. We analyzed the effects of supplementation of ω-3 and ω-6 polyunsaturated fatty acids (PUFAs) with or without nordihydroguaiaretic acid (NDGA) added, an antioxidant and lipoxygenase inhibitor, on metabolic and inflammatory parameters in eSS rats to evaluate whether they can delay development and/or prevent progression of DM...
November 25, 2016: Lipids in Health and Disease
https://www.readbyqxmd.com/read/27881363/association-between-prediabetes-and-risk-of-cardiovascular-disease-and-all-cause-mortality-systematic-review-and-meta-analysis
#13
Yuli Huang, Xiaoyan Cai, Weiyi Mai, Meijun Li, Yunzhao Hu
OBJECTIVES:  To evaluate associations between different definitions of prediabetes and the risk of cardiovascular disease and all cause mortality. DESIGN:  Meta-analysis of prospective cohort studies. DATA SOURCES:  Electronic databases (PubMed, Embase, and Google Scholar). SELECTION CRITERIA:  Prospective cohort studies from general populations were included for meta-analysis if they reported adjusted relative risks with 95% confidence intervals for associations between the risk of composite cardiovascular disease, coronary heart disease, stroke, all cause mortality, and prediabetes...
November 23, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27873429/low-association-between-fasting-and-ogtt-stimulated-glucose-levels-with-hba1c-in-overweight-children-and-adolescents
#14
Stefan Ehehalt, Susanna Wiegand, Antje Körner, Roland Schweizer, Klaus-Peter Liesenkötter, Carl-Joachim Partsch, Gunnar Blumenstock, Ulrike Spielau, Christian Denzer, Michael B Ranke, Andreas Neu, Gerhard Binder, Martin Wabitsch, Wieland Kiess, Thomas Reinehr
BACKGROUND: Diabetes and prediabetes are defined based on different methods such as fasting glucose, glucose at 2-hour in oral glucose tolerance test (OGTT), and glycated hemoglobin A1c (HbA1c). These parameters probably describe different deteriorations in glucose metabolism limiting the exchange between each other in definitions of diabetes. OBJECTIVE: To investigate the relationship between OGTT and HbA1c in overweight and obese children and adolescents living in Germany...
November 22, 2016: Pediatric Diabetes
https://www.readbyqxmd.com/read/27812581/a-comparative-study-of-the-antidiabetic-effects-exerted-by-live-and-dead-multi-strain-probiotics-in-the-type-2-diabetes-model-of-mice
#15
Xiangfei Li, Qi Xu, Tian Jiang, Shuguang Fang, Gang Wang, Jianxin Zhao, Hao Zhang, Wei Chen
Type 2 diabetes is a metabolic syndrome characterized by insulin resistance and relative insulin deficiency. In this study, the anti-diabetic effects of live and dead multi-strain probiotics were explored and compared in a high-fat and streptozotocin-induced model of type 2 diabetes in mice. Either live or dead probiotics were daily administered orally to the mice over 10 weeks. Both live and dead multi-strain probiotics reduced HbA1C and leptin levels, improved glucose tolerance, and protected against the impairment of the pancreas, while the live probiotic showed a greater ability to reduce fasting and postprandial blood glucose levels...
December 7, 2016: Food & Function
https://www.readbyqxmd.com/read/27795816/update-on-pre-diabetes-focus-on-diagnostic-criteria-and-cardiovascular-risk
#16
REVIEW
Antonino Di Pino, Francesca Urbano, Salvatore Piro, Francesco Purrello, Agata Maria Rabuazzo
Pre-diabetes, which is typically defined as blood glucose concentrations higher than normal but lower than the diabetes threshold, is a high-risk state for diabetes and cardiovascular disease development. As such, it represents three groups of individuals: Those with impaired fasting glucose (IFG), those with impaired glucose tolerance (IGT) and those with a glycated haemoglobin (HbA1c) between 39-46 mmol/mol. Several clinical trials have shown the important role of IFG, IGT and HbA1c-pre-diabetes as predictive tools for the risk of developing type 2 diabetes...
October 15, 2016: World Journal of Diabetes
https://www.readbyqxmd.com/read/27792861/pre-diabetes-and-serum-sex-steroid-hormones-among-us-men
#17
R Arthur, S Rohrmann, H Møller, E Selvin, A S Dobs, N Kanarek, W Nelson, E A Platz, M Van Hemelrijck
Several studies demonstrate a link between diabetes and sex steroid hormones, but the link with pre-diabetes remains elusive. In this study, we hypothesize that pre-diabetes, which is characterised by having impaired fasting glucose and/or impaired glucose tolerance and/or impaired HbA1C, may influence circulating sex steroid hormone concentrations in men. Thus, we investigated whether serum sex steroid hormone concentrations differ between men with and without pre-diabetes. We analyzed data for 1139 men who were aged 20+ years when they participated in the Third National Health and Nutrition Examination Survey...
January 2017: Andrology
https://www.readbyqxmd.com/read/27754018/js-ksh-jsh-chl-01-1-cardio-metabolic-risks-in-hypertension-are-we-different-from-western-societies
#18
Hiroshi Itoh
Many hypertension guidelines have been published mainly from Western countries to standardize the management of hypertension all over the world, however, the significance of hypertension, along with other cardio-metabolic risks, such as obesity, diabetes or dyslipidemia should differ among different races. This paper compares the relevance of hypertension, one of the most important cardio-metabolic risk factors, in Asian and Western societies.1) Low target level of blood pressure control for diabetic hypertensives in JapanIn the Japanese Society of Hypertension Guidelines for the management of Hypertension (JSH2014), the target of blood pressure (BP) control in hypertensive patients with diabetes was set as < 130/80 mmHg...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27749986/insulin-secretagogues-for-prevention-or-delay-of-type-2-diabetes-mellitus-and-its-associated-complications-in-persons-at-increased-risk-for-the-development-of-type-2-diabetes-mellitus
#19
REVIEW
Bianca Hemmingsen, David Peick Sonne, Maria-Inti Metzendorf, Bernd Richter
BACKGROUND: The projected rise in the incidence of type 2 diabetes mellitus (T2DM) could develop into a substantial health problem worldwide. Whether insulin secretagogues (sulphonylureas and meglitinide analogues) are able to prevent or delay T2DM and its associated complications in people at risk for the development of T2DM is unknown. OBJECTIVES: To assess the effects of insulin secretagogues on the prevention or delay of T2DM and its associated complications in people with impaired glucose tolerance, impaired fasting blood glucose, moderately elevated glycosylated haemoglobin A1c (HbA1c) or any combination of these...
October 17, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27736009/the-effect-of-growth-hormone-gh-replacement-on-blood-glucose-homeostasis-in-adult-nondiabetic-patients-with-gh-deficiency-real-life-data-from-the-nordinet-%C3%A2-international-outcome-study
#20
Matthias M Weber, Beverly M K Biller, Birgitte Tønnes Pedersen, Effie Pournara, Jens Sandahl Christiansen, Charlotte Höybye
OBJECTIVE: To assess the effect of 4 years' growth hormone (GH) replacement on glucose homeostasis and evaluate factors affecting glycosylated haemoglobin (HbA1c ) in adults with growth hormone deficiency (GHD). DESIGN: NordiNet(®) International Outcome Study, a noninterventional study, monitors long-term effectiveness and safety of GH replacement [Norditropin(®) (somatropin), Novo Nordisk A/S] in real-life clinical practice. PATIENTS: Nondiabetic patients (n = 245) with adult-onset GHD (age ≥20 years at GH start), ≥4 years' GH replacement and HbA1c values at baseline and 4 years were included in the analysis...
October 13, 2016: Clinical Endocrinology
keyword
keyword
21530
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"