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Impaired glucose tolerance. Hba1c

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https://www.readbyqxmd.com/read/27894750/risk-factors-for-autonomic-and-somatic-nerve-dysfunction-in-different-stages-of-glucose-tolerance
#1
Rumyana Dimova, Tsvetalina Tankova, Velina Guergueltcheva, Ivailo Tournev, Nevena Chakarova, Greta Grozeva, Lilia Dakovska
AIM: The present study evaluates autonomic and somatic nerve function in different stages of glucose tolerance and its correlation with different cardio-metabolic parameters. MATERIAL AND METHODS: Four hundred seventy-eight subjects, mean age 49.3±13.7years and mean BMI 31.0±6.2kg/m2, divided according to glucose tolerance: 130 with normal glucose tolerance (NGT), 227 with prediabetes (125 with impaired fasting glucose (IFG) and 102 with isolated impaired glucose tolerance (iIGT)), and 121 with newly-diagnosed T2D (NDT2D), were enrolled...
November 6, 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27884155/long-chain-polyunsaturated-fatty-acids-lcpufas-and-nordihydroguaiaretic-acid-ndga-modulate-metabolic-and-inflammatory-markers-in-a-spontaneous-type-2-diabetes-mellitus-model-stillman-salgado-rats
#2
Alejandro Dain, Gaston Repossi, Gustavo T Diaz-Gerevini, Jairam Vanamala, Undurti N Das, Aldo R Eynard
BACKGROUND: Diabetes mellitus (DM) is a complex disease with alterations in metabolic and inflammatory markers. Stillman Salgado rats (eSS) spontaneously develop type 2 DM by middle age showing progressive impairment of glucose tolerance with hyperglycemia, hypertriglyceridemia and hyperinsulinemia. We analyzed the effects of supplementation of ω-3 and ω-6 polyunsaturated fatty acids (PUFAs) with or without nordihydroguaiaretic acid (NDGA) added, an antioxidant and lipoxygenase inhibitor, on metabolic and inflammatory parameters in eSS rats to evaluate whether they can delay development and/or prevent progression of DM...
November 25, 2016: Lipids in Health and Disease
https://www.readbyqxmd.com/read/27881363/association-between-prediabetes-and-risk-of-cardiovascular-disease-and-all-cause-mortality-systematic-review-and-meta-analysis
#3
Yuli Huang, Xiaoyan Cai, Weiyi Mai, Meijun Li, Yunzhao Hu
OBJECTIVES:  To evaluate associations between different definitions of prediabetes and the risk of cardiovascular disease and all cause mortality. DESIGN:  Meta-analysis of prospective cohort studies. DATA SOURCES:  Electronic databases (PubMed, Embase, and Google Scholar). SELECTION CRITERIA:  Prospective cohort studies from general populations were included for meta-analysis if they reported adjusted relative risks with 95% confidence intervals for associations between the risk of composite cardiovascular disease, coronary heart disease, stroke, all cause mortality, and prediabetes...
November 23, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27873429/low-association-between-fasting-and-ogtt-stimulated-glucose-levels-with-hba1c-in-overweight-children-and-adolescents
#4
Stefan Ehehalt, Susanna Wiegand, Antje Körner, Roland Schweizer, Klaus-Peter Liesenkötter, Carl-Joachim Partsch, Gunnar Blumenstock, Ulrike Spielau, Christian Denzer, Michael B Ranke, Andreas Neu, Gerhard Binder, Martin Wabitsch, Wieland Kiess, Thomas Reinehr
BACKGROUND: Diabetes and prediabetes are defined based on different methods such as fasting glucose, glucose at 2-hour in oral glucose tolerance test (OGTT), and glycated hemoglobin A1c (HbA1c). These parameters probably describe different deteriorations in glucose metabolism limiting the exchange between each other in definitions of diabetes. OBJECTIVE: To investigate the relationship between OGTT and HbA1c in overweight and obese children and adolescents living in Germany...
November 22, 2016: Pediatric Diabetes
https://www.readbyqxmd.com/read/27812581/a-comparative-study-of-the-antidiabetic-effects-exerted-by-live-and-dead-multi-strain-probiotics-in-the-type-2-diabetes-model-of-mice
#5
Xiangfei Li, Qi Xu, Tian Jiang, Shuguang Fang, Gang Wang, Jianxin Zhao, Hao Zhang, Wei Chen
Type 2 diabetes is a metabolic syndrome characterized by insulin resistance and relative insulin deficiency. In this study, the anti-diabetic effects of live and dead multi-strain probiotics were explored and compared in a high-fat and streptozotocin-induced model of type 2 diabetes in mice. Either live or dead probiotics were daily administered orally to the mice over 10 weeks. Both live and dead multi-strain probiotics reduced HbA1C and leptin levels, improved glucose tolerance, and protected against the impairment of the pancreas, while the live probiotic showed a greater ability to reduce fasting and postprandial blood glucose levels...
November 4, 2016: Food & Function
https://www.readbyqxmd.com/read/27795816/update-on-pre-diabetes-focus-on-diagnostic-criteria-and-cardiovascular-risk
#6
REVIEW
Antonino Di Pino, Francesca Urbano, Salvatore Piro, Francesco Purrello, Agata Maria Rabuazzo
Pre-diabetes, which is typically defined as blood glucose concentrations higher than normal but lower than the diabetes threshold, is a high-risk state for diabetes and cardiovascular disease development. As such, it represents three groups of individuals: Those with impaired fasting glucose (IFG), those with impaired glucose tolerance (IGT) and those with a glycated haemoglobin (HbA1c) between 39-46 mmol/mol. Several clinical trials have shown the important role of IFG, IGT and HbA1c-pre-diabetes as predictive tools for the risk of developing type 2 diabetes...
October 15, 2016: World Journal of Diabetes
https://www.readbyqxmd.com/read/27792861/pre-diabetes-and-serum-sex-steroid-hormones-among-us-men
#7
R Arthur, S Rohrmann, H Møller, E Selvin, A S Dobs, N Kanarek, W Nelson, E A Platz, M Van Hemelrijck
Several studies demonstrate a link between diabetes and sex steroid hormones, but the link with pre-diabetes remains elusive. In this study, we hypothesize that pre-diabetes, which is characterised by having impaired fasting glucose and/or impaired glucose tolerance and/or impaired HbA1C, may influence circulating sex steroid hormone concentrations in men. Thus, we investigated whether serum sex steroid hormone concentrations differ between men with and without pre-diabetes. We analyzed data for 1139 men who were aged 20+ years when they participated in the Third National Health and Nutrition Examination Survey...
October 28, 2016: Andrology
https://www.readbyqxmd.com/read/27754018/js-ksh-jsh-chl-01-1-cardio-metabolic-risks-in-hypertension-are-we-different-from-western-societies
#8
Hiroshi Itoh
Many hypertension guidelines have been published mainly from Western countries to standardize the management of hypertension all over the world, however, the significance of hypertension, along with other cardio-metabolic risks, such as obesity, diabetes or dyslipidemia should differ among different races. This paper compares the relevance of hypertension, one of the most important cardio-metabolic risk factors, in Asian and Western societies.1) Low target level of blood pressure control for diabetic hypertensives in JapanIn the Japanese Society of Hypertension Guidelines for the management of Hypertension (JSH2014), the target of blood pressure (BP) control in hypertensive patients with diabetes was set as < 130/80 mmHg...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27749986/insulin-secretagogues-for-prevention-or-delay-of-type-2-diabetes-mellitus-and-its-associated-complications-in-persons-at-increased-risk-for-the-development-of-type-2-diabetes-mellitus
#9
REVIEW
Bianca Hemmingsen, David Peick Sonne, Maria-Inti Metzendorf, Bernd Richter
BACKGROUND: The projected rise in the incidence of type 2 diabetes mellitus (T2DM) could develop into a substantial health problem worldwide. Whether insulin secretagogues (sulphonylureas and meglitinide analogues) are able to prevent or delay T2DM and its associated complications in people at risk for the development of T2DM is unknown. OBJECTIVES: To assess the effects of insulin secretagogues on the prevention or delay of T2DM and its associated complications in people with impaired glucose tolerance, impaired fasting blood glucose, moderately elevated glycosylated haemoglobin A1c (HbA1c) or any combination of these...
October 17, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27736009/the-effect-of-growth-hormone-gh-replacement-on-blood-glucose-homeostasis-in-adult-nondiabetic-patients-with-gh-deficiency-real-life-data-from-the-nordinet-%C3%A2-international-outcome-study
#10
Matthias M Weber, Beverly M K Biller, Birgitte Tønnes Pedersen, Effie Pournara, Jens Sandahl Christiansen, Charlotte Höybye
OBJECTIVE: To assess the effect of 4 years' growth hormone (GH) replacement on glucose homeostasis and evaluate factors affecting glycosylated haemoglobin (HbA1c ) in adults with growth hormone deficiency (GHD). DESIGN: NordiNet(®) International Outcome Study, a noninterventional study, monitors long-term effectiveness and safety of GH replacement [Norditropin(®) (somatropin), Novo Nordisk A/S] in real-life clinical practice. PATIENTS: Nondiabetic patients (n = 245) with adult-onset GHD (age ≥20 years at GH start), ≥4 years' GH replacement and HbA1c values at baseline and 4 years were included in the analysis...
October 13, 2016: Clinical Endocrinology
https://www.readbyqxmd.com/read/27730082/relationship-of-glycemic-control-markers-1-5-anhydroglucitol-fructosamine-and-glycated-hemoglobin-among-asian-indians-with-different-degrees-of-glucose-intolerance
#11
Thyparambil Aravindakshan Pramodkumar, Ramamoorthy Jayashri, Kuppan Gokulakrishnan, Kaliyaperumal Velmurugan, Rajendra Pradeepa, Ranjit Mohan Anjana, Viswanathan Mohan
OBJECTIVE: 1,5 anhydroglucitol (1,5 AG) is emerging as a marker of short-term glycemic control. We measured levels of 1,5 AG, fructosamine (FA), and glycated hemoglobin (HbA1c) in Asian Indians with different degrees of glucose intolerance. MATERIALS AND METHODS: We recruited 210 individuals with normal glucose tolerance (NGT; n = 60), impaired glucose tolerance (IGT; n = 50), and Type 2 diabetes mellitus (T2DM; n = 100) from a large tertiary diabetes center in Chennai in Southern India...
September 2016: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27729556/carotid-artery-intima-media-thickness-predicts-major-cardiovascular-events-during-7-year-follow-up-in-64-year-old-women-irrespective-of-other-glucometabolic-factors
#12
Caroline Schmidt, Göran Bergström
Cardiovascular (CV) disease (CVD) is a leading cause of morbidity and mortality worldwide. Most CV events are caused by atherosclerosis. Diabetes and impaired glucose tolerance are associated with greater carotid intima-media thickness (IMT) and increased risk for CVD. The present study examined if common carotid artery IMT (CCAIMT) is predictive of CVD irrespective of glucose tolerance category and glycated hemoglobin (HbA1c) in a sample of 639 women with different glucose tolerance categories. During 7-year follow-up, 30 events in the cardiac and 32 events in the cerebral territory were documented...
October 11, 2016: Angiology
https://www.readbyqxmd.com/read/27647185/effect-of-chinese-herbal-medicine-jinlida-granule-in-treatment-of-patients-with-impaired-glucose-tolerance
#13
Ya-Lin Shi, Wen-Juan Liu, Xiao-Fang Zhang, Wei-Juan Su, Ning-Ning Chen, Shu-Hua Lu, Li-Ying Wang, Xiu-Lin Shi, Zhi-Bin Li, Shu-Yu Yang
BACKGROUND: Diabetes mellitus (DM) remains a major health problem worldwide. Several clinical trials have shown the superiority of the Traditional Chinese Medicine in delaying or reversing the development and progression of DM. This study aimed to evaluate the efficacy of Jinlida (JLD) granule, a Chinese herbal recipe, in the treatment of impaired glucose tolerance (IGT) and its effect on the prevention of DM. METHODS: Sixty-five IGT patients were randomized to receive one bag of JLD granules three times daily (JLD group, n = 34) or no drug intervention (control group, n = 31) for 12 weeks...
2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27642936/js-ksh-jsh-chl-01-1-cardio-metabolic-risks-in-hypertension-are-we-different-from-western-societies
#14
Hiroshi Itoh
Many hypertension guidelines have been published mainly from Western countries to standardize the management of hypertension all over the world, however, the significance of hypertension, along with other cardio-metabolic risks, such as obesity, diabetes or dyslipidemia should differ among different races. This paper compares the relevance of hypertension, one of the most important cardio-metabolic risk factors, in Asian and Western societies.1) Low target level of blood pressure control for diabetic hypertensives in JapanIn the Japanese Society of Hypertension Guidelines for the management of Hypertension (JSH2014), the target of blood pressure (BP) control in hypertensive patients with diabetes was set as < 130/80 mmHg...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27642745/-posttransplantation-diabetes-mellitus-in-patients-after-kidney-transplantation-incidence-and-risk-factors
#15
Isabell Jahn, Martin Busch, Undine Ott, Gunter Wolf, Wilgard Battefeld
BACKGROUND: Transplantation (NTX) associated ischemia-reperfusion-mechanisms and the predisposition for insulin resistance are discussed as causes of a posttransplantation diabetes mellitus (PTDM). Furthermore, immunosuppressants can have a damaging effect on insulin secretion. METHODS: 55 metabolically healthy patients with an endstage renal disease (age 52 ± 14 years, body mass index 27 ± 5 kg / m(2), blood pressure 137 ± 15/82 ± 11 mmHg) were included in a prospectively cohort study...
September 2016: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/27628439/insulin-resistance-and-beta-cell-dysfunction-in-people-with-prediabetes-according-to-criteria-based-on-glycemia-and-glycosylated-hemoglobin
#16
Andrea Tura, Christian Göbl, Ermanno Moro, Giovanni Pacini
Impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) are well-known conditions of risk for diabetes. Recently, 1h-hyperglycemia (1h-HG), i.e., glycemia > 8.6 mmol/l, has been suggested as further condition of diabetes risk. Moreover, in 2010 the American Diabetes Association included the measurement of glycosylated hemoglobin (HbA1c) among the criteria of diabetes risk (5.7-6.4%). Aim of this study was investigating all these different conditions of diabetes risk, with specific focus on possible insulin sensitivity and beta-cell function changes, when 1h-HG, and further HbA1c-prediabetes, are added to the already deeply studied condition of IFG/IGT...
September 14, 2016: Endocrine Journal
https://www.readbyqxmd.com/read/27614450/long-term-clinical-effect-of-tangyiping-granules-on-patients-with-impaired-glucose-tolerance
#17
Yan-Qin Huang, Qing-Feng Yang, Hua Wang, Yun-Sheng Xu, Wei Peng, Yue-Hua Jiang
OBJECTIVE: To evaluate the long-term clinical effect of Tangyiping Granules (, TYP) on patients with impaired glucose tolerance (IGT) to achieve normal glucose tolerance (NGT) and hence preventing them from conversion to diabetes mellitus (DM). METHODS: In total, 127 participants with IGT were randomly assigned to the control (63 cases, 3 lost to follow-up) and treatment groups (64 cases, 4 lost to follow-up) according to the random number table. The control group received lifestyle intervention alone, while the patients in the treatment group took orally 10 g of TYP twice daily in addition to lifestyle intervention for 12 weeks...
September 2016: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/27612595/changes-in-hba1c-levels-and-body-mass-index-after-successful-decompression-surgery-in-patients-with-type-2-diabetes-mellitus-and-lumbar-spinal-stenosis-results-of-a-2-year-follow-up-study
#18
Kyoung-Tae Kim, Dae-Chul Cho, Joo-Kyung Sung, Chi Heon Kim, Hyun Kang, Du Hwan Kim
BACKGROUND CONTEXT: Lumbar spinal stenosis (LSS) can hinder a patient's physical activity, which in turn can impair glucose tolerance and body weight regulation in patients with type 2 diabetes mellitus (DM-2). Therefore, successful lumbar surgery could facilitate glycemic control and body weight regulation. PURPOSE: This study aimed to evaluate the effects of postoperative improvement in physical activity on body mass index (BMI) and hemoglobin A1c (HbA1c) level in patients with LSS and DM-2 over a 2-year follow-up period...
September 6, 2016: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/27606813/serum-amylase-levels-in-relation-to-islet-%C3%AE-cell-function-in-patients-with-early-type-2-diabetes
#19
Lei Zhuang, Jian-Bin Su, Xiu-Lin Zhang, Hai-Yan Huang, Li-Hua Zhao, Feng Xu, Tong Chen, Xue-Qin Wang, Gang Wu, Xiao-Hua Wang
OBJECTIVE: The insulin-pancreatic acinar axis may play a major role in pancreatic function. Amylase is an exocrine enzyme that is produced by pancreatic acinar cells, and low serum amylase levels may be associated with endocrine diseases, such as metabolic syndrome and diabetes. We hypothesized that low serum amylase levels may be associated with impaired islet β cell function in type 2 diabetes. Therefore, we investigated the relationship between the serum amylase levels and islet β cell function in patients with early type 2 diabetes...
2016: PloS One
https://www.readbyqxmd.com/read/27539099/serum-nesfatin-1-levels-in-patients-with-different-glucose-tolerance-levels
#20
S Algul, Y Ozkan, O Ozcelik
The aim of this study was to compare the levels of nesfatin-1 in healthy subjects with those in prediabetic and diabetic patients who have different glucose tolerance levels. Overall, 100 subjects were divided into 5 groups healthy control (C), impaired fasting glycaemia (IFG), impaired glucose tolerance (IGT), metabolic syndrome (MS) and type 2 diabetes mellitus, (Type 2 DM). Glycated hemoglobin (HbA1c) assessed the glycemic control. Homeostasis model assessment of insulin resistance (HOMA-IR) was determined using computer analyses...
August 19, 2016: Physiological Research
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