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https://www.readbyqxmd.com/read/28648016/-mechanisms-of-cytoskeleton-and-pi3k%C3%AE-rhoa-in-fine-particulate-matter-deteriorating-phagocytosis-defect-of-alveolar-macrophage-in-mice-with-chronic-obstructive-pulmonary-disease
#1
Q Xia, S T Hu, X L Zeng, H R Bao, X J Liu
Objective: To explore the mechanism of cytoskeleton and PI3Kδ-RhoA in fine particulate matter deteriorating phagocytosis defect of alveolar macrophage (AM) in chronic obstructive pulmonary disease (COPD) mice. Methods: Forty mice were randomly divided into four groups: health control group, COPD group, health PM2.5 group, COPD PM2.5 group and with ten in each group. A mouse model of COPD was established by cigarette smoke exposure, and health PM2.5 group and COPD PM2.5 group mice were given PM2.5 (588 μg/m(3)) aerosol inhalation for 90 days...
June 27, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28647984/-screening-on-key-techniques-used-for-surveillance-and-disposal-of-public-health-emergencies
#2
Q R Zhu, L Yang, H Y Ma, W Q Xie, L M Cong, L W Xu
Objective: To explore the key techniques used for surveillance and disposal of infectious diseases, food poisoning and hospital infection to improve the ability of surveillance and disposal on public health emergency. Methods: Framework on surveillance and disposal of infectious diseases, food poisoning and hospital infection was set up, based on literature review and expert group discussion. Delphi method and technique for order preference by similarity to ideal solution comprehensive evaluation method were used for ordering preference by similarity, to screen key techniques set for surveillance and disposal of the above said events...
June 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28647972/-relationship-between-pesticide-exposure-and-adverse-pregnancy-outcomes-among-reproductive-couples-in-rural-areas-of-china
#3
Y M Qu, S Chen, J J Li, R R Jin, H Pan, Y Jiang
Objective: To analyze the association between pesticide exposure and adverse pregnancy outcomes in women from the rural areas of China. Methods: Data of "National Free Preconception Health Examination Project (NFPHEP)" from January 2010 to December 2012 was used for analysis. A total of 248 501 families that were planning to deliver a baby in the next 6 months were enrolled. Data on paternal exposure to pesticides before or during pregnancy was collected through questionnaires, with related outcomes on pregnancy recorded by doctors...
June 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28647965/-paying-attention-to-different-health-needs-of-different-ethnic-groups-in-process-health-for-all-program
#4
T G Li, M Wang
In recent years, great effort has been made in the promotion of health for all in China. Articles on column on chronic and non-communicable disease risk factors in Uighur population, analysis based on the investigation results of Uygur population health status in the Kashi area of Xinjiang of China and similar domestic and foreign studies showed that the health data in different countries are different. The differences in health related data exist in different ethnic groups even in same country or same ethnic group in different areas...
June 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28647926/importance-of-gold-guidelines-for-chronic-obstructive-pulmonary-disease
#5
J Sadlonova, D Osinova, E Rozborilova, O Osina, E Novakova, V Sadlonova
In December 2011, a major revision of GOLD 2011 guidelines was published based on the evidence-based medicine. The goal of GOLD 2011 is to determine the severity of the disease, its impact on the patient's health, and the risk of future events; all of which eventually guide therapy. A combined COPD assessment according to GOLD 2011 considers the patient's level of symptoms, spirometry abnormalities, risk of exacerbation, and the presence of comorbidities. GOLD 2011 stratifies patients into four basic groups labeled A, B, C, and D...
June 25, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28647914/shifting-the-physical-inactivity-curve-worldwide-by-closing-the-gender-gap
#6
Grégore I Mielke, Inacio Crochemore M da Silva, Tracy L Kolbe-Alexander, Wendy J Brown
PURPOSE: The aims of this study were to (i) examine gender differences in physical inactivity in countries with different levels of Human Development Index (HDI); and (ii) assess whether small changes in the prevalence of inactivity in women could achieve the World Health Organization's (WHO) global inactivity target. METHODS: Data on inactivity were extracted for 142 countries for the year 2010 from the WHO Data Repository. Data for HDI were obtained for the year 2010 from the United Nations Development Program...
June 24, 2017: Sports Medicine
https://www.readbyqxmd.com/read/28647843/alarming-increase-in-the-registration-of-degenerative-rotator-cuff-related-lesions-a-nationwide-epidemiological-study-investigating-244-519-patients
#7
Nina Monrad, Ann Ganestam, Thomas Kallemose, Kristoffer Weisskirchner Barfod
PURPOSE AND HYPOTHESIS: Shoulder lesions are common and a challenge to diagnose. They often result in significant disability for the patient and are an economic burden to society. From recent studies, an increasing incidence has been reported. The purpose of this study was to investigate and map the incidence of shoulder lesions in Denmark from 1996 to 2013 with focus on sex, age and geographical area. METHODS: The Danish National Patient Registry was searched retrospectively to find the number of shoulder lesions in Denmark during the period 1996-2013...
June 24, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28647804/estimating-the-long-term-functional-burden-of-osteoporosis-related-fractures
#8
S Fischer, K A Kapinos, A Mulcahy, L Pinto, O Hayden, R Barron
Although fractures are associated with short-term reductions in functional status, there is limited information on longer-term burden of fracture. This study documents evidence of an association between fractures and significant declines and functional health and activities that persist but attenuate beyond two years. INTRODUCTION: Although fractures are associated with short-term reductions in functional status and may have other short-term effects on healthcare utilization (hospitalization and follow-up care), there is limited information on long-term burden of fracture beyond 12 to 24 months post-fracture...
June 24, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28647728/impact-of-five-tobacco-endgame-strategies-on-future-smoking-prevalence-population-health-and-health-system-costs-two-modelling-studies-to-inform-the-tobacco-endgame
#9
Frederieke S van der Deen, Nick Wilson, Christine L Cleghorn, Giorgi Kvizhinadze, Linda J Cobiac, Nhung Nghiem, Tony Blakely
OBJECTIVE: There is growing international interest in advancing 'the tobacco endgame'. We use New Zealand (Smokefree goal for 2025) as a case study to model the impacts on smoking prevalence (SP), health gains (quality-adjusted life-years (QALYs)) and cost savings of (1) 10% annual tobacco tax increases, (2) a tobacco-free generation (TFG), (3) a substantial outlet reduction strategy, (4) a sinking lid on tobacco supply and (5) a combination of 1, 2 and 3. METHODS: Two models were used: (1) a dynamic population forecasting model for SP and (2) a closed cohort (population alive in 2011) multistate life table model (including 16 tobacco-related diseases) for health gains and costs...
June 24, 2017: Tobacco Control
https://www.readbyqxmd.com/read/28647693/recognition-investigation-and-management-of-mitochondrial-disease
#10
REVIEW
James E Davison, Shamima Rahman
Mitochondria are dynamic organelles present in virtually all human cells that are needed for a multitude of cellular functions, including energy production, control of cell apoptosis and numerous biochemical catabolic and synthetic pathways that are critical for cellular health. Primary mitochondrial disorders are a group of greater than 200 single gene defects arising from two genomes (nuclear and mitochondrial) leading to mitochondrial dysfunction, and are associated with extremely heterogeneous phenotypes...
June 24, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28647664/patient-perceived-responsiveness-of-primary-care-systems-across-europe-and-the-relationship-with-the-health-expenditure-and-remuneration-systems-of-primary-care-doctors
#11
Anna Maria Murante, Chiara Seghieri, Milena Vainieri, Willemijn L A Schäfer
BACKGROUND: Health systems are expected to be responsive, that is to provide services that are user-oriented and respectful of people. Several surveys have tried to measure all or some of the dimensions of the responsiveness (e.g. autonomy, choice, clarity of communication, confidentiality, dignity, prompt attention, quality of basic amenities, and access to family and community support), however there is little evidence regarding the level of responsiveness of primary care (PC) systems...
June 6, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28647634/more-successful-results-with-less-energy-in-endovenous-laser-ablation-treatment-long-term-comparison-of-bare-tip-fiber980nm-laser-and-radial-tip-fiber1470nm-laser-application
#12
Ümit Arslan, Eyüpserhat Çalık, Mehmet Tort, Ziya Yıldız, Ali İhsan Tekin, Hüsnü Kamil Limandal, Mehmet Ali Kaygın, Özgür Dağ, Bilgehan Erkut
BACKGROUND: Varices and venous insufficiency are common and serious health problems in the general population which affect quality of life. Endothermal treatment of the great saphenous vein has become the first line of treatment for superficial venous reflux, and the endovenous laser ablation (EVLA) method has been widely accepted all over the world. In this method, ablation is provided by a laser fiber inserted into the lumen of the vein. Initially, the fibers were 810 nm, but today the fibers are usually 940, 980, or 1470 nm...
June 21, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28647607/bioaccessibility-and-risk-assessment-of-essential-and-non-essential-elements-in-vegetables-commonly-consumed-in-swaziland
#13
Robert Londi Mnisi, Peter P Ndibewu, Lihle D Mafu, Gabriel C Bwembya
The green leafy vegetables (Mormodica involucrate, Bidens pilosa and Amaranthus spinosus) are economic; seasonal; locally grown and easily available; easy to propagate and store; highly nutritious food substances that form an important component of diets. This study applies a physiology based extraction technique (PBET) to mimic digestion of these vegetables to determine the fraction of essential (Fe and Zn) and non-essential elements (Cd, Cr and Pb) that are made available for absorption after ingestion. Prior to the application of the PBET, the vegetables were cooked adopting indigenous Swazi cooking methods...
June 22, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28647578/regular-source-of-care-for-the-elderly-a-cross-national-comparative-study-of-hong-kong-with-11-developed-countries
#14
Samuel Yeung-Shan Wong, Dan Zou, Roger Y Chung, Regina W Sit, Dexing Zhang, Dicken Chan, Eng Kiong Yeoh, Jean W Woo
OBJECTIVE: This study aimed to give an international perspective of health service gaps for caring for elderly individuals and explore the role of primary care for caring for elderly individuals with chronic conditions in Hong Kong. DESIGN: Cross-sectional, telephone survey. SETTING: Hong Kong. PARTICIPANT: A sample of 1000 Chinese participants in Hong Kong aged 60 or older. MEASUREMENTS: Questionnaire extracted from the Commonwealth Fund 2014 International Health Policy Survey of Older Adults...
June 21, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28647550/longitudinal-prediction-of-quality-of-life-scores-and-locomotion-in-individuals-with-traumatic-spinal-cord-injury
#15
Shivayogi V Hiremath, Nathan S Hogaboom, Melissa R Roscher, Lynn A Worobey, Michelle L Oyster, Michael L Boninger
OBJECTIVES: The study examined differences in quality of life scores for groups based on transitions in locomotion status at 1, 5, and 10 years post-discharge in a sample of people with spinal cord injury (SCI). We also investigated whether demographic factors and transitions in locomotion status can predict quality of life measures at these time points. DESIGN: Retrospective case study of the National SCI Database. SETTING: Model SCI Systems Centers...
June 21, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28647541/response-tailored-protocol-versus-the-fixed-12weeks-of-dual-sofosbuvir-daclatasvir-treatment-in-egyptian-patients-with-chronic-hepatitis-c-genotype-4-infection-a-randomized-open-label-non-inferiority-trial
#16
Mostafa Yakoot, Alaa M Abdo, Siham Abdel-Rehim, Sherine Helmy
BACKGROUND: The most recent European Association for the Study of the Liver (EASL) 2016 Guidelines on treatment of hepatitis C (HCV), allowed for shortening the course of treatment for some subsets of patients with sofosbuvir/ledipasvir and with grazoprevir/elbasvir based on cutoff baseline HCV RNA values. We hypothesized that it would be prudent to also consider an objectively assuring very rapid, on-treatment, virologic response to therapy at week 2 (vRVR) before taking the decision of shortening the treatment duration...
May 17, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28647413/omega-6-fatty-acids-opposing-associations-with-risk-the-ludwigshafen-risk-and-cardiovascular-health-study
#17
Graciela E Delgado, Winfried März, Stefan Lorkowski, Clemens von Schacky, Marcus E Kleber
BACKGROUND: Omega-6 polyunsaturated fatty acids (omega-6 PUFA) are recommended in European cardiovascular prevention guidelines. However, individual fatty acids have distinct biological functions, and there have been conflicting reports about the association of omega-6 PUFA with cardiovascular risk. OBJECTIVE: The aim of our study was to investigate the association of individual omega-6 fatty acids with mortality in a cohort of patients referred for coronary angiography...
June 1, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28647335/incidence-and-duration-of-increased-somatic-cell-count-in-swedish-dairy-cows-and-associations-with-milking-system-type
#18
J Frössling, A Ohlson, C Hallén-Sandgren
Mastitis is one of the most costly diseases in dairy cows worldwide. Increased somatic cell count (SCC) is an indication of mastitis, often subclinical, which implies bacterial infection without clinical signs of inflammation. The aim was to investigate the occurrence of elevated udder SCC (defined as ≥200,000 cells/mL) over the lactation period, and before and after the dry period, for cows of different parity. The aim was also to analyze the association between prevalence and incidence of increased udder SCC and information on cow and herd level, such as breed and milking system type...
June 21, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28647254/quantifying-public-health-benefits-of-environmental-strategy-of-pm2-5-air-quality-management-in-beijing-tianjin-hebei-region-china
#19
Li Chen, Mengshuang Shi, Suhuan Li, Shuang Gao, Hui Zhang, Yanling Sun, Jian Mao, Zhipeng Bai, Zhongliang Wang, Jiang Zhou
In 2013, China issued "Air Pollution Prevention and Control Action Plan (Action Plan)" to improve air quality. To assess the benefits of this program in Beijing-Tianjin-Hebei (BTH) region, where the density of population and emissions vary greatly, we simulated the air quality benefit based on BenMAP to satisfy the Action Plan. In this study, we estimate PM2.5 concentration using Voronoi spatial interpolation method on a grid with a spatial resolution of 1×1km(2). Combined with the exposure-response function between PM2...
July 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/28647246/environmentally-relevant-concentrations-of-aminopolycarboxylate-chelating-agents-mobilize-cd-from-humic-acid
#20
Ashley E North, Sophia Sarpong-Kumankomah, Andrew R Bellavie, Wade M White, Jürgen Gailer
Although Cd is a pollutant of public health relevance, many dietary sources from which it can be absorbed into human tissues remain unknown. While it is well established that the biogeochemical cycle of Cd involves its complexation with environment-derived ligands (e.g., humic acids, HAs) and anthropogenic ones (e.g., chelating agents, CAs), the interaction of Cd with both of these ligands is less well understood. To gain insight, a HA-Cd complex was injected on a size-exclusion chromatography (SEC) column coupled on-line with a flame atomic absorption spectrometer (FAAS) using 10mmol/L Tris buffer (pH8...
July 2017: Journal of Environmental Sciences (China)
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