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https://www.readbyqxmd.com/read/29031193/the-retention-of-lacosamide-in-patients-with-epilepsy-and-intellectual-disability-in-three-specialised-institutions
#1
J Brenner, H J M Majoie, S van Beek, J A Carpay
PURPOSE: We describe the effectiveness of lacosamide as adjunctive therapy in patients with epilepsy and an intellectual disability. This information is relevant, as few data exist pertaining to this population with a high prevalence of (intractable) epilepsy. METHODS: We performed a retrospective study in three specialised institutions. Inclusion criteria were (1) focal onset or symptomatic generalized (2) therapy-resistant epilepsy, (3) intellectual disability and (4) residence in a care-facility for people with intellectual disabilities (PWID)...
October 3, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29031187/modelling-transitions-in-urban-water-systems
#2
W Rauch, C Urich, P M Bach, B C Rogers, F J de Haan, R R Brown, M Mair, D T McCarthy, M Kleidorfer, R Sitzenfrei, A Deletic
Long term planning of urban water infrastructure requires acknowledgement that transitions in the water system are driven by changes in the urban environment, as well as societal dynamics. Inherent to the complexity of these underlying processes is that the dynamics of a system's evolution cannot be explained by linear cause-effect relationships and cannot be predicted under narrow sets of assumptions. Planning therefore needs to consider the functional behaviour and performance of integrated flexible infrastructure systems under a wide range of future conditions...
September 22, 2017: Water Research
https://www.readbyqxmd.com/read/29031166/can-the-perceived-barriers-to-psychological-treatment-scale-be-used-to-investigate-treatment-barriers-among-females-with-disordered-and-non-disordered-eating-behaviours
#3
Natasha T Innes, Bonnie A Clough, Jamin J Day, Leanne M Casey
There is a lack of psychometrically sound instruments to assess treatment barriers among individuals with disordered eating behaviours. This study examined the factor structure and psychometric properties of the Perceived Barriers to Psychological Treatment scale (PBPT; Mohr et al., 2010) among a sample of individuals with disordered eating behaviours. Participants were 708 females aged 14 years and older who completed an online survey. The sample was randomly divided in two for the conduct of exploratory (EFA) and confirmatory (CFA) factor analyses...
September 28, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29031154/thermally-stable-microemulsions-comprising-imidazolium-based-surface-active-ionic-liquids-non-polar-ionic-liquid-and-ethylene-glycol-as-polar-phase
#4
Manvir Kaur, Gurbir Singh, Sandeep Kumar, Navnidhi, Tejwant Singh Kang
Ionic liquid (IL), 1-ethyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide, [C2mim] [Tf2N], as a non-polar phase in conjunction with polar ethylene glycol (EG) forms microemulsions stabilized by surface active ionic liquids (SAILs), N-methyl-N-alkylimidazolium chlorides, [Cnmim] [Cl], where n = 8, 12 and 16 in conjunction with decanol as co-surfactant. The phase behaviour of the ternary systems has been investigated and three regions of microemulsions - polar-in-ionic liquid, bicontinuous and ionic liquid-in-polar, have been identified using electrical conductivity measurements...
October 7, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29031048/trends-in-perinatal-health-in-metropolitan-france-from-1995-to-2016-results-from-the-french-national-perinatal-surveys
#5
B Blondel, B Coulm, C Bonnet, F Goffinet, C Le Ray
OBJECTIVE: To study trends in the main indicators of perinatal health, medical practices and risk factors in France since 1995. POPULATION AND METHOD: All live births during one week in 1995 (n=13,318), 2003 (n=14,737), 2010 (n=14,903) and 2016 (n=13,384). Data were from interviews of women in postpartum wards and from medical records and were compared between years. RESULTS: Between 1995 and 2016, maternal age and body mass index increased steadily...
October 9, 2017: Journal of gynecology obstetrics and human reproduction
https://www.readbyqxmd.com/read/29029067/pharmacodynamics-of-fosfomycin-against-esbl-and-or-carbapenemase-producing-enterobacteriaceae
#6
Fiona Fransen, Kelly Hermans, Maria J B Melchers, Claudia C M Lagarde, Joseph Meletiadis, Johan W Mouton
Background: The increase in antibiotic resistance in Gram-negative bacteria and the limited therapeutic options due to the shortage of new antibiotics have increased the interest of the 'old' antibiotic fosfomycin in the treatment of infections. However, there are contradictory reports on the pharmacodynamics of and emergence of resistance to fosfomycin. Methods: Time-kill assays were performed with 11 ESBL-positive and 3 ESBL-negative strains, exposing the bacteria to 2-fold static concentrations from 0...
October 4, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29029021/aetiological-heterogeneity-of-head-and-neck-squamous-cell-carcinomas-the-role-of-human-papillomavirus-infections-smoking-and-alcohol
#7
Nada J Farsi, Marie-Claude Rousseau, Nicolas Schlecht, Geneviève Castonguay, Paul Allison, Phuc Félix Nguyen-Tan, Denis Soulieres, Francois Coutlée, Michael Hier, Sreenath Madathil, Eduardo L Franco, Belinda Nicolau
Tobacco and alcohol consumption are the main risk factors for head and neck squamous cell carcinoma (HNSCC). In addition, human papillomavirus (HPV) infection plays a causal role in oropharyngeal cancer (OPC), a subset of HNSCC. We assessed the independent effects of tobacco, alcohol, and HPV infection on OPC risk in the Head and Neck Cancer(HeNCe) Life study, a hospital-based case-control study of HNSCC with frequency-matched controls by age and sex from four Montreal hospitals. Interviewers collected information on socio-demographic and behavioural factors...
September 28, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/29028612/where-do-spontaneous-first-impressions-of-faces-come-from
#8
Harriet Over, Richard Cook
Humans spontaneously attribute a wide range of traits to strangers based solely on their facial features. These first impressions are known to exert striking effects on our choices and behaviours. In this paper, we provide a theoretical account of the origins of these spontaneous trait inferences. We describe a novel framework ('Trait Inference Mapping') in which trait inferences are products of mappings between locations in 'face space' and 'trait space'. These mappings are acquired during ontogeny and allow excitation of face representations to propagate automatically to associated trait representations...
October 10, 2017: Cognition
https://www.readbyqxmd.com/read/29028579/the-views-of-first-time-mothers-completing-an-intervention-to-reduce-postpartum-weight-retention-a-qualitative-evaluation-of-the-mums-online-study
#9
Paige van der Pligt, Kylie Ball, Kylie D Hesketh, David Crawford, Megan Teychenne, Karen Campbell
BACKGROUND: maternal postpartum weight retention (PPWR) has implications for short and long term weight-related health of both the mother and child. Little is known about how mothers perceive they may be best supported to achieve a healthy postpartum weight and healthy lifestyle behaviours. Evaluating existing postpartum weight focussed intervention strategies is an important step in the planning of future programs aimed at supporting new mothers. AIM: to describe the perspectives of women who completed the mums OnLiNE pilot intervention, regarding the acceptability and effectiveness of a program which aimed to limit PPWR and promote healthy diet and physical activity behaviours in new mothers...
September 21, 2017: Midwifery
https://www.readbyqxmd.com/read/29028562/common-and-differential-factors-associated-with-abstinence-and-poly-drug-use-among-australian-adolescents
#10
Simone Pettigrew, Michelle Jongenelis, David Lawrence, Wavne Rikkers
BACKGROUND: Social norms relating to youth substance use are changing. In Australia, alcohol use among adolescents has fallen dramatically and tobacco and cannabis use have also reduced, albeit more moderately. The aim of the present study was to identify (i) factors associated with compliance with recommendations for zero intake of alcohol, tobacco, and cannabis and (ii) factors associated with poly drug use (intake of all three substances). METHODS: As part of the Young Minds Matter Study, a self-report survey was administered to 1661 Australian adolescents aged 15-17 years...
October 10, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29028506/sodium-deoxycholate-mediated-enhanced-solubilization-and-stability-of-hydrophobic-drug-clozapine-in-pluronic-micelles
#11
Pankaj Singla, Onkar Singh, Shruti Chabba, V K Aswal, Rakesh Kumar Mahajan
In this report, the solubilization behaviour of a hydrophobic drug Clozapine (CLZ) in micellar suspensions of pluronics having different hydrophilic lipophilic balance (HLB) ratios viz. P84, F127 and F108 in the absence and presence of bile salt sodium deoxycholate (SDC) has been studied. UV-Vis spectroscopy has been exploited to determine the solubilization capacity of the investigated micellar systems in terms of drug loading efficiency, average number of drug molecules solubilized per micelle (ns), partition coefficient (P) and standard free energy of solubilization (∆G(°))...
October 7, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29028342/radical-pair-based-magnetoreception-amplified-by-radical-scavenging-resilience-to-spin-relaxation
#12
Daniel Rudolf Kattnig
Birds and several other species are equipped with the remarkable ability to sense the geomagnetic field for the purpose of navigation and orientation. The primary detection mechanism of this compass sense is uncertain but appears to originate from a truly quantum process involving spin-correlated radical pairs. In order to elicit sensitivity to weak magnetic fields, such as the Earth's magnetic field, the underlying spin dynamics must be protected from fast decoherence. In this work, we elucidate the effects of spin relaxation on a recently suggested reaction scheme involving three radicals, instead of a radical pair, doublet-quartet interconversion under magnetic interactions, and a spin-selective scavenging reaction...
October 13, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29028288/hypochlorous-acid-is-anti-pruritic-and-anti-inflammatory-in-a-mouse-model-of-atopic-dermatitis
#13
Tomoki Fukuyama, Britta C Martel, Keith Linder, Sarah Ehling, Joy Rachel Ganchingco, Wolfgang Bäumer
BACKGROUND: It has been reported that topical hypochlorous acid (HOCl) formulations lead to relief of itch in human patients with atopic dermatitis, however the specific anti-pruritic mechanism of action remains unclear. OBJECTIVE: To confirm itch relief and reduction of lesions in a mouse model of atopic dermatitis and to elucidate possible HOCl's mode of action. METHODS: In this study, the effects of topical administration of HOCl hydrogel (0...
October 13, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29028233/ethics-in-public-health-call-for-shared-moral-public-health-literacy
#14
Els L M Maeckelberghe, Peter Schröder-Bäck
Public Health (PH) in Europe has become much more vocal about its moral understandings since 1992. The rising awareness that PH issues were inseparable from issues of human rights and social justice almost self-evidently directed the agenda of EUPHA and the European Public Health (EPH)-conferences. Problems of cultural and behavioural change, and environmental issues on a global scale were also added. The Section Ethics in PH invited the EPH community to join in 'arm chair thinking': coming together at conferences not only to share the 'how' and 'what' of PH research, practices and policies but also the 'why'...
October 1, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/29028227/a-strong-tb-programme-embedded-in-a-developing-primary-healthcare-system-is-a-lose-lose-situation-insights-from-patient-and-community-perspectives-in-cambodia
#15
Neisha Sundaram, Richard James, Um Sreynimol, Pen Linda, Joanne Yoong, Saint Saly, Pichenda Koeut, Mao Tan Eang, Richard Coker, Mishal S Khan
As exemplified by the situation in Cambodia, disease specific (vertical) health programmes are often favoured when the health system is fragile. The potential of such an approach to impede strengthening of primary healthcare services has been studied from a health systems perspective in terms of access and quality of care. In this bottom-up, qualitative study we investigate patient and community member experiences of health services when a strong tuberculosis (TB) programme is embedded into a relatively underutilized primary healthcare system...
October 1, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/29028070/gene-expression-in-human-adipose-derived-stem-cells-comparison-of-2d-films-3d-electrospun-meshes-or-co-cultured-scaffolds-with-two-way-paracrine-effects
#16
S C Hess, W J Stark, D Mohn, N Cohrs, S Märsmann, M Calcagni, P Cinelli, J Buschmann
Finding the appropriate cues to trigger the desired differentiation is a challenge in tissue engineering when stem cells are involved. In this regard, three-dimensional environments are often compared to cells' two-dimensional culture behaviour (plastic culture dish). Here, we compared the gene expression pattern of human adipose-derived stem cells (ASC) seeded in a three-dimensional (3D) electrospun mesh and on a two-dimensional (2D) film - both of exactly the same material. Additionally, we conducted experiments with a scaffold floating above a film to investigate two-way paracrine effects (co-system)...
October 13, 2017: European Cells & Materials
https://www.readbyqxmd.com/read/29028060/molecular-emulsions-from-charge-order-to-domain-order
#17
Aurélien Perera
Aqueous mixtures of small molecules, such as lower n-alkanols for example, are known to be micro-segregated, with domains in the nano-meter range. One consequence of this micro-segregation would be the existence of long range domain-domain oscillatory correlations in the various atom-atom pair correlation functions, and subsequent pre-peaks in the corresponding atom-atom structure factors, in the q-vector range corresponding to nano-sized domains. However, no such pre-peak have ever been observed in the large corpus of radiation scattering data published so far on aqueous mixtures of small n-alkanols...
October 13, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29028057/exploring-the-coherent-interaction-in-a-hybrid-system-of-hollow-gold-nanoprisms-and-cyanine-dye-j-aggregates-role-of-plasmon-hybridization-mediated-local-electric-field-enhancement
#18
Kamalika Das, Bidhan Hazra, Manabendra Chandra
In this work, we probed the possibility of observing strong plasmon-exciton interactions in hollow gold nanoprism-J-aggregate nanocomposites. Several different hollow gold nanoprisms (HGNs) with different aspect ratios were synthesized. This allowed us to systematically tune the LSPR energies through the exciton energy of the PIC-J-aggregate, which in turn allowed us to have direct determination of the coupling strength of HGN-J-aggregate composites. Hybrid nanosystems were prepared by adsorbing and assembling 1,1'-diethyl-2,2'-cyanine (pseudoisocyanine or PIC) iodide onto the surface of hollow gold nanoprisms...
October 13, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29027903/functional-dichotomy-in-spinal-vs-prefrontal-projecting-locus-coeruleus-modules-splits-descending-noradrenergic-analgesia-from-ascending-aversion-and-anxiety-in-rats
#19
Stefan Hirschberg, Yong Li, Andrew Randall, Eric J Kremer, Anthony E Pickering
The locus coeruleus (LC) projects throughout the brain and spinal cord and is the major source of central noradrenaline. It remains unclear whether the LC acts functionally as a single global effector or as discrete modules. Specifically, while spinal-projections from LC neurons can exert analgesic actions, it is not known whether they can act independently of ascending LC projections. Using viral vectors taken up at axon terminals, we expressed chemogenetic actuators selectively in LC neurons with spinal (LC:(SC)) or prefrontal cortex (LC:(PFC)) projections...
October 13, 2017: ELife
https://www.readbyqxmd.com/read/29027865/the-bidirectional-relation-of-emotion-perception-and-social-judgments-the-effect-of-witness-emotion-expression-on-perceptions-of-moral-behaviour-and-vice-versa
#20
Ursula Hess, Helen Landmann, Shlomo David, Shlomo Hareli
The present research tested the notion that emotion expression and context perception are bidirectionally related. Specifically, in two studies focusing on moral violations (N = 288) and positive moral deviations (N = 245) respectively, we presented participants with short vignettes describing behaviours that were either (im)moral, (in)polite or unusual together with a picture of the emotional reaction of a person who supposedly had been a witness to the event. Participants rated both the emotional reactions observed and their own moral appraisal of the situation described...
October 13, 2017: Cognition & Emotion
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