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Adhesive capsulitis

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https://www.readbyqxmd.com/read/29330921/four-and-a-half-domain-2-fhl2-scaffolding-protein-is-a-marker-of-connective-tissues-of-developing-digits-and-regulates-fibrogenic-differentiation-of-limb-mesodermal-progenitors
#1
C I Lorda-Diez, J A Montero, C Sanchez-Fernandez, J A Garcia-Porrero, J Chimal-Monroy, J M Hurle
FHL2 is a multifunctional scaffolding protein of well-known function regulating cell signaling cascades and gene transcription in cancer tissues. However, its function in embryonic systems is poorly characterized. Here, we show that Fhl2 is involved in the differentiation of connective tissues of developing limb autopod. We show that Fhl2 exhibits spatially restricted and temporally dynamic expression around the tendons of developing digits, interphalangeal joint capsules, and fibrous peridigital tissue. Immunolabeling analysis of the skeletal progenitors identified a predominant, but not exclusive, cytoplasmic distribution of FHL2 being associated with focal adhesions and actin cytoskeleton...
January 12, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29324877/impact-of-extra-articular-pathologies-on-groin-pain-an-arthroscopic-evaluation
#2
Mitsunori Kaya
PURPOSE: For patients who have anterior hip pain evaluated by Patrick's test and tenderness at Scarpa's triangle, we perform periarticular debridement based on the hypothesis that extra-articular pathologies are responsible for the hip pain. The purpose of this study was to categorize the endoscopic extra-articular findings and to evaluate the clinical significance of periarticular pathologies in anterior hip pain. METHODS: Arthroscopic findings of 77 patients who underwent periarthritic debridement were evaluated...
2018: PloS One
https://www.readbyqxmd.com/read/29273079/united-kingdom-frozen-shoulder-trial-uk-frost-multi-centre-randomised-12-month-parallel-group-superiority-study-to-compare-the-clinical-and-cost-effectiveness-of-early-structured-physiotherapy-versus-manipulation-under-anaesthesia-versus-arthroscopic-capsular
#3
Stephen Brealey, Alison L Armstrong, Andrew Brooksbank, Andrew Jonathan Carr, Charalambos P Charalambous, Cushla Cooper, Belen Corbacho, Joseph Dias, Iona Donnelly, Lorna Goodchild, Catherine Hewitt, Ada Keding, Lucksy Kottam, Sarah E Lamb, Catriona McDaid, Matthew Northgraves, Gerry Richardson, Sara Rodgers, Sarwat Shah, Emma Sharp, Sally Spencer, David Torgerson, Francine Toye, Amar Rangan
BACKGROUND: Frozen shoulder (also known as adhesive capsulitis) occurs when the capsule, or the soft tissue envelope around the ball and socket shoulder joint, becomes scarred and contracted, making the shoulder tight, painful and stiff. It affects around 1 in 12 men and 1 in 10 women of working age. Although this condition can settle with time (typically taking 1 to 3 years), for some people it causes severe symptoms and needs referral to hospital. Our aim is to evaluate the clinical and cost-effectiveness of two invasive and costly surgical interventions that are commonly used in secondary care in the National Health Service (NHS) compared with a non-surgical comparator of Early Structured Physiotherapy...
December 22, 2017: Trials
https://www.readbyqxmd.com/read/29247478/chinese-medicine-tongxinluo-capsule-alleviates-cerebral-microcirculatory-disturbances-in-ischemic-stroke-by-modulating-vascular-endothelial-function-and-inhibiting-leukocyte-endothelial-cell-interactions-in-mice-a-two-photon-laser-scanning-microscopy-study
#4
Shen Liu, Cong Wei, Ning Kang, Qilong He, Junqing Liang, Hongtao Wang, Liping Chang, Daohong Chen, Qiuyan Zhang, Chengcheng Chang, Junfang Zhang, Hong Ren, Yiling Wu
OBJECTIVE: The aim of this study was to examine the effect of Tongxinluo capsule (TXL), a Chinese medicine prescription, on cerebral microcirculatory disturbances after permanent middle cerebral artery occlusion (pMCAO) in mice using two-photon laser scanning microscopy (TPLSM) and further explore the underlying mechanisms. METHODS: C57BL/6J mice were subjected to pMCAO and orally administered with TXL (3.0, 1.5 and 0.75 g/kg/day) at 1h, 3h and 21h after pMCAO. The following parameters were examined at 6h and 24h after pMCAO: neurological deficit, infarct volume, blood-brain barrier (BBB) permeability, cerebral microvessel structure, brain microcirculation (TPLSM imaging), vasoactive factors and adhesion molecules...
December 15, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29242941/physical-therapy-in-the-management-of-frozen-shoulder
#5
Hui Bin Yvonne Chan, Pek Ying Pua, Choon How How
Frozen shoulder, also known as adhesive capsulitis, is a common presentation in the primary care setting and can be significantly painful and disabling. The condition progresses in three stages: freezing (painful), frozen (adhesive) and thawing, and is often self-limiting. Common conservative treatments include nonsteroidal anti-inflammatory drugs, oral glucocorticoids, intra-articular glucocorticoid injections and/or physical therapy. However, many physicians may find themselves limited to prescribing medications for treatment...
December 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/29212435/adhesive-capsulitis-of-the-hip
#6
Hee Joong Kim, Jeong Joon Yoo, Hong Suk Kwak, Hyung Jun Jeong, Min Nyeon Kim, Wonyeong Seo
PURPOSE: Adhesive capsulitis of the hip (ACH) is not a well-defined disease entity. We evaluated the change in the clinical features of patients whose chief complaint was inability to sit cross-legged on the floor. All patients had painful limitation in hip joint motion. Based on the diagnosis of ACH, active stretching exercise (ASE) was recommended. METHODS: In February 2013 and June 2014, a total of 44 patients (50 hips), who visited outpatient clinic in 2011, were evaluated by telephone interviews...
September 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/29202560/the-use-of-hyaluronic-acid-in-the-treatment-of-shoulder-capsulitis-a-systematic-review
#7
R Papalia, A Tecame, G Vadalà, F Russo, M Perna, G Papalia, F Bressi, S Sterzi, V Denaro
Adhesive capsulitis (AC) is a common pathological condition of the shoulder characterized by painful restriction of range of motion (ROM) of the glenohumeral joint. Currently, no consensus has been reached regarding the best treatment. Hyaluronic acid (HA) injection is a safe procedure that can result in significant improvement in active and passive ROM, alleviating pain and improving shoulder function. We systematically reviewed current literature in order to evaluate the best evidence about the effectiveness of intra-articular HA injection for the treatment of primary AC...
December 4, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29200621/the-effects-of-extracorporeal-shock-wave-therapy-on-pain-and-range-of-motion-in-patients-with-adhesive-capsulitis
#8
Sangho Lee, Sangyong Lee, Mugeun Jeong, Hyunju Oh, Kwansub Lee
[Purpose] This study examined the effects of extracorporeal shock wave therapy on pain and range of motion in patients with adhesive capsulitis. [Subjects and Methods] Thirty patients with adhesive capsulitis were divided into an experimental group (n=15) that would be treated with extracorporeal shock wave therapy and a control group (n=15) that would be treated only with conservative physical therapy. Both groups were treated three times a week over a four-week period. [Results] An intra-group comparison before and after the treatment showed that both groups experienced a decline in pain and an increase in their range of motion that were statistically significant...
November 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/29190634/focal-segmental-glomerulosclerosis-associated-with-chronic-progressive-external-ophthalmoplegia-and-mitochondrial-dna-a3243g-mutation
#9
Kaori Narumi, Eikan Mishima, Yukako Akiyama, Tetsuro Matsuhashi, Takashi Nakamichi, Kiyomi Kisu, Shuhei Nishiyama, Hajime Ikenouchi, Akio Kikuchi, Rumiko Izumi, Mariko Miyazaki, Takaaki Abe, Hiroshi Sato, Sadayoshi Ito
Focal segmental glomerulosclerosis (FSGS) is caused by various etiologies, with mitochondrial dysfunction being one of the causes. FSGS is known to be associated with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS), which is a subclass of mitochondrial disease. However, it has rarely been reported in other mitochondrial disease subclasses. Here, we reported a 20-year-old man diagnosed with FSGS associated with chronic progressive external ophthalmoplegia (CPEO) due to mitochondrial DNA (mtDNA) 3243A>G mutation...
November 30, 2017: Nephron
https://www.readbyqxmd.com/read/29190292/tnf-%C3%AE-blockade-suppresses-pericystic-inflammation-following-anthelmintic-treatment-in-porcine-neurocysticercosis
#10
Siddhartha Mahanty, Miguel A Orrego, Carla Cangalaya, M Paz Adrianzen, Gianfranco Arroyo, Juan Calcina, Armando E Gonzalez, Héctor H García, Cristina Guerra-Giraldez, Theodore E Nash
BACKGROUND: Neurocysticercosis (NCC) is an infection of the brain with the larval cyst of the tapeworm, Taenia solium. Cysticidal treatment induces parasite killing resulting in a post inflammatory response and seizures, which generally requires corticosteroid treatment to control inflammation. The nature of this response and how to best control it is unclear. We investigated the anti-inflammatory effects of pretreatment with etanercept (ETN), an anti-tumor necrosis factor agent, or dexamethasone (DEX), a high potency corticosteroid, on the post treatment inflammatory response in naturally infected pigs with neurocysticercosis after a single dose of the cysticidal drug praziquantel (PZQ)...
November 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29171901/current-advances-in-aptamer-assisted-technologies-for-detecting-bacterial-and-fungal-toxins
#11
REVIEW
Naser Alizadeh, Mohammad Yousef Memar, Bahareh Mehramuz, Saeed Shirgir Abibiglou, Fateme Hemmati, Hossein Samadi Kafil
Infectious diseases are among the common leading causes of morbidity and mortality worldwide. Associated with the emergence of new infectious diseases, the increasing number of antimicrobial resistant isolates presents a seriousthreat to public health and hospitalized patients. A microbial pathogen may elicit several host responses and use a variety of mechanisms to evade host defenses. These methods and mechanisms include capsule, LPS or cell wall components, adhesions and toxins. Toxins inhibit phagocytosis, cause septic shock and host cell damages by binding to host surface receptors and invasion...
November 24, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29154803/new-scale-down-methodology-from-commercial-to-lab-scale-to-optimize-plant-derived-soft-gel-capsule-formulations-on-a-commercial-scale
#12
Sana Oishi, Shin-Ichiro Kimura, Shuji Noguchi, Mio Kondo, Yosuke Kondo, Yoshiyuki Shimokawa, Yasunori Iwao, Shigeru Itai
A new scale-down methodology from commercial rotary die scale to laboratory scale was developed to optimize a plant-derived soft gel capsule formulation and eventually manufacture superior soft gel capsules on a commercial scale, in order to reduce the time and cost for formulation development. Animal-derived and plant-derived soft gel film sheets were prepared using an applicator on a laboratory scale and their physicochemical properties, such as tensile strength, Young's modulus, and adhesive strength, were evaluated...
November 14, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29129609/hydrodilatation-with-corticosteroid-for-the-treatment-of-adhesive-capsulitis-a-systematic-review
#13
REVIEW
Michael Catapano, Nimish Mittal, John Adamich, Dinesh Kumbhare, Harpreet Sangha
BACKGROUND: Current evidence suggests that corticosteroid injection alone expedites the recovery of pain-free ROM in patients with adhesive capsulitis compared to physiotherapy or placebo. However, it remains unclear whether the addition of hydrodilatation with corticosteroid provides improvement in pain-free ROM as well as pain relief. OBJECTIVE: Review the literature to determine whether the combined intervention of hydrodilatation and corticosteroid injection expedites restoration of pain-free range of motion (ROM) compared to a control of corticosteroid injection in patients with adhesive capsulitis...
November 9, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29123001/effective-remedy-for-encapsulating-peritoneal-sclerosis-with-ureteroileal-fistula
#14
Masataka Banshodani, Hideki Kawanishi, Sadanori Shintaku, Masahiro Yamashita, Misaki Moriishi, Shinichiro Tsuchiya
Encapsulating peritoneal sclerosis (EPS), treated with surgical enterolysis as a final option, may become refractory to surgical intervention due to intraperitoneal complications. We report the case of a 59-year-old man presenting with EPS who underwent enterolysis at the age of 50, following 15 years of peritoneal dialysis (PD) and peritonitis. During the patient's first surgery, complete surgical enterolysis could not be performed due to severe intestinal adhesions with a deteriorated/calcified small bowel...
November 2017: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/29117299/high-vs-low-dose-corticosteroid-injection-in-the-treatment-of-adhesive-capsulitis-with-severe-pain-a-randomized-controlled-double-blind-study
#15
Kyou Hyun Kim, Jong Wook Park, Sang Jun Kim
Objective: To compare the degree of pain relief between high-dose (40 mg of triamcinolone acetonide) and low-dose (20 mg of triamcinolone acetonide) corticosteroid injections in patients with severe pain due to adhesive capsulitis. Design: A prospective, randomized, double-blind, dose-comparative study. Subjects: A total of 32 patients who were diagnosed with adhesive capsulitis and who expressed severe pain intensity, 8 or more points on a numeric rating scale (NRS)...
October 7, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29100771/clinical-outcomes-of-arthroscopic-360%C3%A2-capsular-release-for-idiopathic-adhesive-capsulitis-in-the-lateral-decubitus-position
#16
Gregory L Cvetanovich, Timothy S Leroux, Eamon D Bernardoni, Jason T Hamamoto, Bryan M Saltzman, Nikhil N Verma, Anthony A Romeo
PURPOSE: To report outcomes after arthroscopic 360° capsular release in the lateral decubitus position for idiopathic glenohumeral adhesive capsulitis without manipulation under anesthesia. METHODS: A retrospective case series of patients who underwent arthroscopic capsular release in the lateral decubitus position for idiopathic adhesive capsulitis with minimum 2-year follow-up was conducted. Patient demographics, preoperative range of motion (ROM), postoperative ROM, and the postoperative outcome scores, visual analog scale for pain, Single Assessment Numeric Evaluation, Simple Shoulder Test, and American Shoulder and Elbow Surgeons scores, were recorded...
October 31, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29096980/arthroscopic-management-of-septic-arthritis-of-the-native-shoulder-a-systematic-review
#17
REVIEW
Muzammil Memon, Jeffrey Kay, Lydia Ginsberg, Darren de Sa, Nicole Simunovic, Kristian Samuelsson, George S Athwal, Olufemi R Ayeni
PURPOSE: To investigate arthroscopic management of native shoulder joint septic arthritis-specifically, indications, patient outcomes, and complications. METHODS: PubMed, MEDLINE, and Embase were used to search the literature, and data abstraction was performed independently and in duplicate. The Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) checklist guided reporting and data abstraction. The quality of all included studies was assessed with the Methodological Index for Non-randomized Studies (MINORS) criteria...
October 30, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29047366/the-use-of-cinacalcet-hinders-the-diagnosis-of-parathyroid-carcinoma-in-a-chronic-dialysis-patient-a-case-report
#18
Daisuke Takada, Tatsuo Tsukamoto, Miho Fuse, Shinpei Kada, Motoko Yanagita
BACKGROUND: Secondary hyperparathyroidism (SHPT) is a common complication in patients receiving chronic dialysis therapy. Although cinacalcet can control parathyroid function and bone turnover, preventing ectopic calcification remains challenging. Cinacalcet can also suppress PTH secretion due to parathyroid carcinoma in the same way as it does for parathyroid hyperplasia in the uremic condition. We present a case of parathyroid carcinoma partially controlled by cinacalcet, in which tumorous calcinosis was successfully resolved by total parathyroidectomy...
October 18, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/29037627/does-ultrasound-therapy-add-to-the-effects-of-exercise-and-mobilization-in-frozen-shoulder-a-pilot-randomized-double-blind-clinical-trial
#19
Safoora Ebadi, Bijan Forogh, Ehsan Fallah, Arash Babaei Ghazani
OBJECTIVE: This study intended to determine the extent to which Ultrasound could add to the effects of exercise and manual therapy in the rehabilitation treatment of primary adhesive capsulitis. DESIGN: A pilot double blind randomized clinical trial was carried out on 50 patients suffering from primary adhesive capsulitis. Intervention included continuous 3 MHz, 1.5 w/cm2 Ultrasound, applied for the first group and sham Ultrasound for the second group. In addition specific stretching and strengthening exercises as well as glenohumeral joint mobilization were delivered to both groups...
October 2017: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/29018641/prevalence-and-determinants-of-frozen-shoulder-in-patients-with-diabetes-a-single-center-experience-from-pakistan
#20
Faisal Inayat, Nouman Safdar Ali, Haroon Shahid, Fariha Younus
Introduction Frozen shoulder (FS) or adhesive capsulitis is a constellation of symptoms like pain, stiffness, and/or functional deficit at the glenohumeral joint. It is one of the musculoskeletal complications in patients with diabetes that can be particularly debilitating. The aim of this study is to estimate the prevalence of FS and to compare the determinants of this disease in a population with diabetes from Lahore, Pakistan. Materials and Methods We carried out this cross-sectional study on a systematically randomized sample of 80 patients with diabetes...
August 6, 2017: Curēus
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