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Francey T

T Francey, A Schweighauser
BACKGROUND: The traditional systemic heparinization used for anticoagulation in extracorporeal therapies may cause fatal complications in animals at risk of bleeding. HYPOTHESIS/OBJECTIVES: To develop and validate a protocol of regional citrate anticoagulation (RCA) for intermittent hemodialysis in dogs. ANIMALS: A total of 172 dogs treated with hemodialysis for acute kidney injury. METHODS: In vitro titration was performed, adding trisodium citrate and calcium chloride to heparinized canine blood...
January 2018: Journal of Veterinary Internal Medicine
R Peter, D Demuth, C Müntener, M Lampart, D Heim, M Mevissen, G Schüpbach-Regula, S Schuller, F Stucki, B Willi, W Burkhardt, T Francey, C Nett, F Tschuor, H Naegeli
Bacterial resistances to antimicrobial drugs pose serious public health challenges. The observed increase of resistances is attributed to the uncontrolled, massive and often unnecessary administration of antibiotics both in human and veterinary medicine. To support the responsible use of antimicrobials in animals and help veterinarians selecting the most suitable antimicrobial drugs, we developed the as a comprehensive decision supporting tool providing online access to the current knowledge of rational antibiotic prescription practices...
October 2017: Schweizer Archiv Für Tierheilkunde
D P Dahlem, R Neiger, A Schweighauser, T Francey, M Yerramilli, E Obare, S M L Steinbach
BACKGROUND: Symmetric dimethylarginine (SDMA) is considered a biomarker for early detection of renal dysfunction in human patients with acute kidney injury (AKI). At present, no studies exist analyzing the relevance of SDMA in dogs with AKI. HYPOTHESIS/OBJECTIVES: SDMA would correctly identify dogs with renal disease but would not be able to differentiate between AKI and CKD. ANIMALS: Eighteen healthy control dogs, 48 dogs with AKI, and 29 dogs with CKD...
May 2017: Journal of Veterinary Internal Medicine
C I Gloor, A Schweighauser, T Francey, S Rodriguez-Campos, B Vidondo, B Bigler, S Schuller
OBJECTIVES: To determine the diagnostic performance of two patient-side tests (RDT-1: Test-it™ and RDT-2 Witness®Lepto) in the early diagnosis of canine leptospirosis. METHODS: Retrospective study of 108 dogs with leptospirosis and 53 controls. Leptospirosis was diagnosed based on compatible clinical and clinicopathologic signs and either a single microscopic agglutination test titre_ >800 (n=49), seroconversion (n=53), positive urine real time PCR (RT-PCR) (n=1), evidence of spirochaetes in silver-stained tissues (n=1) or a combination of these (n=4)...
March 2017: Journal of Small Animal Practice
S P Keller, A Kovacevic, J Howard, A Schweighauser, T Francey
OBJECTIVES: Cardiac involvement in the course of acute kidney injury is described in humans as cardiorenal syndrome type 3 but has received only limited attention in dogs. This study was designed to evaluate cardiac injury and dysfunction in acute kidney injury in dogs and its association with outcome. METHODS: This prospective cohort study enrolled 24 client-owned dogs with acute kidney injury. Cardiac disorders were evaluated with thoracic radiographs, echocardiography, 24-hour Holter monitoring and cardiac troponin I concentrations within 2 days of admission and 7 to 10 days later...
August 2016: Journal of Small Animal Practice
A Schweighauser, T Francey
Poisoning with ethylene glycol as contained in antifreeze can rapidly lead to irreversible acute renal failure and other organ damage. It carries a grave prognosis unless diagnosed early and adequate treatment is initiated within 8 hours of ingestion. Toxicity of ethylene glycol is related to the production of toxic metabolites by the enzyme alcohol dehydrogenase (ADH), leading to early signs of severe polyuria (PU) and polydipsia (PD), gastritis, ataxia and central nervous depression, followed by progressive dehydration, and ultimately oligoanuric renal failure...
February 2016: Schweizer Archiv Für Tierheilkunde
N Donnelly, R Harper, D Branagh, J Francey, H Easlea, V Faro-Maza, T Hunniford, A Mooney, J McLaughlin
This paper presents recent improvement of a Wi-Fi based vital signs monitor used for in-hospital monitoring in medium-risk settings. Valuable insight into design strengths and weaknesses has been gained and device improvements have been confirmed with real-world use. Integration with intuitive central station software is considered with respect to balancing functionality and performance. Practical use of the early warning system in challenging clinical environments has enabled further understanding of the potential impact of the system...
August 2015: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
J L Pouchelon, C E Atkins, C Bussadori, M A Oyama, S L Vaden, J D Bonagura, V Chetboul, L D Cowgill, J Elliot, T Francey, G F Grauer, V Luis Fuentes, N Sydney Moise, D J Polzin, A M Van Dongen, N Van Israël
OBJECTIVES: There is a growing understanding of the complexity of interplay between renal and cardiovascular systems in both health and disease. The medical profession has adopted the term "cardiorenal syndrome" (CRS) to describe the pathophysiological relationship between the kidney and heart in disease. CRS has yet to be formally defined and described by the veterinary profession and its existence and importance in dogs and cats warrant investigation. The CRS Consensus Group, comprising nine veterinary cardiologists and seven nephrologists from Europe and North America, sought to achieve consensus around the definition, pathophysiology, diagnosis and management of dogs and cats with "cardiovascular-renal disorders" (CvRD)...
September 2015: Journal of Small Animal Practice
S Schuller, T Francey, K Hartmann, M Hugonnard, B Kohn, J E Nally, J Sykes
Leptospirosis is a zoonotic disease with a worldwide distribution affecting most mammalian species. Clinical leptospirosis is common in dogs but appears to be rare in cats. Both dogs and cats, however, can shed leptospires in the urine. This is problematic as it can lead to exposure of humans. The control of leptospirosis, therefore, is important not only from an animal but also from a public health perspective. The aim of this consensus statement is to raise awareness of leptospirosis and to outline the current knowledge on the epidemiology, clinical features, diagnostic tools, prevention and treatment measures relevant to canine and feline leptospirosis in Europe...
March 2015: Journal of Small Animal Practice
N Brown, G Segev, T Francey, P Kass, L D Cowgill
BACKGROUND: Acute kidney injury (AKI) is common in dogs. Few studies have assessed sequential changes in indices of kidney function in dogs with naturally occurring AKI. OBJECTIVE: To document sequential changes of conventional indices of renal function, to better define the course of AKI, and to identify a candidate marker for recovery. ANIMALS: Ten dogs with AKI. METHODS: Dogs were prospectively enrolled and divided into surviving and nonsurviving dogs...
January 2015: Journal of Veterinary Internal Medicine
S Brown, J Elliott, T Francey, D Polzin, S Vaden
Standard therapy forms the basic foundation for care of dogs with glomerular disease, as it is herein recommended for use in all affected animals regardless of causation of the disease. Consensus recommendations target the evaluation and management of proteinuria, inhibition of the renin-angiotensin-aldosterone system, modification in dietary intake with special consideration for those nutrients with renal effects, diagnosis and treatment of systemic hypertension, and evaluation and management of body fluid volume status in dogs with glomerular disease...
November 2013: Journal of Veterinary Internal Medicine
K Gendron, A Christe, S Walter, A Schweighauser, T Francey, M G Doherr, J Lang
Leptospirosis pulmonary haemorrhage syndrome (LPHS) is a frequent manifestation of Leptospira infection in dogs and is associated with a high morbidity and mortality. Three helical 16-slice thoracic CT scans were performed in 10 dogs naturally infected with Leptospira, within 24 hours of admission, and three and seven days later. Patients were sedated and scanned without breathhold, with a protocol adapted for rapid scanning. One dog died of respiratory failure on the morning following the first scan. On the initial scan, imaging features of LPHS included ground-glass nodules (10/10), peribronchovascular interstitial thickening (10/10), diffuse or patchy ground-glass opacity (9/10), solid nodules (8/10) and consolidation (7/10)...
February 15, 2014: Veterinary Record
S Steinbach, J Weis, A Schweighauser, T Francey, R Neiger
BACKGROUND: Neutrophil gelatinase-associated lipocalin (NGAL) is a protein that is used in human medicine as a real-time indicator of acute kidney injury (AKI). HYPOTHESIS: Dogs with AKI have significantly higher plasma NGAL concentration and urine NGAL-to-creatinine ratio (UNCR) compared with healthy dogs and dogs with chronic kidney disease (CKD). ANIMALS: 18 healthy control dogs, 17 dogs with CKD, and 48 dogs with AKI. METHODS: Over a period of 1 year, all dogs with renal azotemia were prospectively included...
March 2014: Journal of Veterinary Internal Medicine
Frank J Kaiser, Morad Ansari, Diana Braunholz, María Concepción Gil-Rodríguez, Christophe Decroos, Jonathan J Wilde, Christopher T Fincher, Maninder Kaur, Masashige Bando, David J Amor, Paldeep S Atwal, Melanie Bahlo, Christine M Bowman, Jacquelyn J Bradley, Han G Brunner, Dinah Clark, Miguel Del Campo, Nataliya Di Donato, Peter Diakumis, Holly Dubbs, David A Dyment, Juliane Eckhold, Sarah Ernst, Jose C Ferreira, Lauren J Francey, Ulrike Gehlken, Encarna Guillén-Navarro, Yolanda Gyftodimou, Bryan D Hall, Raoul Hennekam, Louanne Hudgins, Melanie Hullings, Jennifer M Hunter, Helger Yntema, A Micheil Innes, Antonie D Kline, Zita Krumina, Hane Lee, Kathleen Leppig, Sally Ann Lynch, Mark B Mallozzi, Linda Mannini, Shane McKee, Sarju G Mehta, Ieva Micule, Shehla Mohammed, Ellen Moran, Geert R Mortier, Joe-Ann S Moser, Sarah E Noon, Naohito Nozaki, Luis Nunes, John G Pappas, Lynette S Penney, Antonio Pérez-Aytés, Michael B Petersen, Beatriz Puisac, Nicole Revencu, Elizabeth Roeder, Sulagna Saitta, Angela E Scheuerle, Karen L Schindeler, Victoria M Siu, Zornitza Stark, Samuel P Strom, Heidi Thiese, Inga Vater, Patrick Willems, Kathleen Williamson, Louise C Wilson, Hakon Hakonarson, Fabiola Quintero-Rivera, Jolanta Wierzba, Antonio Musio, Gabriele Gillessen-Kaesbach, Feliciano J Ramos, Laird G Jackson, Katsuhiko Shirahige, Juan Pié, David W Christianson, Ian D Krantz, David R Fitzpatrick, Matthew A Deardorff
Cornelia de Lange syndrome (CdLS) is a multisystem genetic disorder with distinct facies, growth failure, intellectual disability, distal limb anomalies, gastrointestinal and neurological disease. Mutations in NIPBL, encoding a cohesin regulatory protein, account for >80% of cases with typical facies. Mutations in the core cohesin complex proteins, encoded by the SMC1A, SMC3 and RAD21 genes, together account for ∼5% of subjects, often with atypical CdLS features. Recently, we identified mutations in the X-linked gene HDAC8 as the cause of a small number of CdLS cases...
June 1, 2014: Human Molecular Genetics
Ellen A Tsai, Micah A Berman, Laura K Conlin, Heidi L Rehm, Lauren J Francey, Matthew A Deardorff, Jenelle Holst, Maninder Kaur, Emily Gallant, Dinah M Clark, Joseph T Glessner, Shane T Jensen, Struan F A Grant, Peter J Gruber, Hakon Hakonarson, Nancy B Spinner, Ian D Krantz
This report describes an algorithm developed to predict the pathogenicity of copy number variants (CNVs) in large sample cohorts. CNVs (genomic deletions and duplications) are found in healthy individuals and in individuals with genetic diagnoses, and differentiation of these two classes of CNVs can be challenging and usually requires extensive manual curation. We have developed PECONPI, an algorithm to assess the pathogenicity of CNVs based on gene content and CNV frequency. This software was applied to a large cohort of patients with genetically heterogeneous non-syndromic hearing loss to score and rank each CNV based on its relative pathogenicity...
September 2013: American Journal of Medical Genetics. Part A
Sushmita Sen, Pratik Bhojnagarwala, Lauren Francey, Ding Lu, Trevor M Penning, Jeffrey Field
Benzo[a]pyrene (B[a]P), a major human carcinogen in combustion products such as cigarette smoke and diesel exhaust, is metabolically activated into DNA-reactive metabolites via three different enzymatic pathways. The pathways are the anti-(+)-benzo[a]pyrene 7,8-diol 9,10-epoxide pathway (P450/epoxide hydrolase catalyzed) (B[a]PDE), the benzo[a]pyrene o-quinone pathway (aldo ketose reductase (AKR) catalyzed) and the B[a]P radical cation pathway (P450 peroxidase catalyzed). We used a yeast p53 mutagenesis system to assess mutagenesis by B[a]P radical cations...
October 15, 2012: Chemical Research in Toxicology
C A Geigy, A Schweighauser, M Doherr, T Francey
OBJECTIVES: To describe the occurrence of systemic hypertension in dogs with acute kidney injury and the efficacy of amlodipine besylate for its treatment. METHODS: This retrospective study included 52 dogs with acute kidney injury (2007 to 2008) grouped based on the use of amlodipine in their treatment. Systemic blood pressure was measured with an oscillometric device at admission, before, during, and after amlodipine therapy. RESULTS: Occurrence of systolic systemic hypertension (≥160 mmHg) and severe systolic systemic hypertension (≥180 mmHg) was 37% and 15% at admission and increased with hospitalisation to 81% and 62%, respectively...
July 2011: Journal of Small Animal Practice
S Steinbach, B Binkert, A Schweighauser, B Reynolds, J Séguéla, H Lefebvre, T Francey
BACKGROUND: Kinetic assessment of urea, the main end product of protein metabolism, could serve to assess protein catabolism in dogs with chronic kidney disease (CKD). Protein malnutrition and catabolism are poorly documented in CKD and they often are neglected clinically because of a lack of appropriate evaluation tools. HYPOTHESIS: Generation and excretion of urea are altered in dogs with CKD. ANIMALS: Nine dogs with spontaneous CKD (IRIS stages 2-4) and 5 healthy research dogs...
November 2010: Journal of Veterinary Internal Medicine
M Wernick, M Doherr, J Howard, T Francey
OBJECTIVES: To evaluate high-definition and conventional oscillometry in comparison with direct blood pressure measurements in anaesthetised dogs. METHODS: Eight simultaneous readings for systolic, diastolic and mean pressure were obtained directly and with each of two devices in nine anaesthetised dogs. Measurement procedure and validation were based on the 2007 ACVIM guidelines. RESULTS: Sixty-three simultaneous readings were evaluated for each device and direct measurements...
June 2010: Journal of Small Animal Practice
Pedro Boscan, Bruno H Pypendop, Kristine T Siao, Thierry Francey, Kristy Dowers, Larry Cowgill, Jan E Ilkiw
OBJECTIVE: To determine fluid retention, glomerular filtration rate, and urine output in dogs anesthetized for a surgical orthopedic procedure. ANIMALS: 23 dogs treated with a tibial plateau leveling osteotomy. PROCEDURES: 12 dogs were used as a control group. Cardiac output was measured in 5 dogs, and 6 dogs received carprofen for at least 14 days. Dogs received oxymorphone, atropine, propofol, and isoflurane for anesthesia (duration, 4 hours)...
May 2010: American Journal of Veterinary Research
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