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https://www.readbyqxmd.com/read/28738254/stereoselective-protein-binding-studies-of-2-2-hydroxypropanamido-benzoic-acid-enantiomers-in-rat-beagle-dog-and-human-plasma
#1
Qili Zhang, Shasha Li, Danlin Wang, Yunli Zhao, Zhiguo Yu
As the stereoselective plasma protein binding is an important factor for the differences in pharmacokinetic or pharmacodynamic properties of chiral drugs, we elucidated the binding of (R)-/(S)-HPABA to plasma protein. A UHPLC-MS/MS method was developed and validated to the quantitation and equilibrium dialysis method was applied to the separation of bound and unbound drugs. Protein binding reached equilibrium within 12h of incubation at 37°C. Liquid-liquid extraction with ethyl acetate was used for sample preparation...
June 23, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28432797/effects-of-levothyroxine-administration-and-withdrawal-on-the-hypothalamic-pituitary-thyroid-axis-in-euthyroid-dogs
#2
V Ziglioli, D L Panciera, G C Troy, W E Monroe, K M Boes, K R Refsal
BACKGROUND: Chronic supplementation can suppress the hypothalamic-pituitary-thyroid axis (HPTA) and make it difficult to assess thyroid function after withdrawal of levothyroxine. OBJECTIVES: To determine whether the HPTA is suppressed after levothyroxine administration in euthyroid dogs and the time required for resolution of any suppression. ANIMALS: Twenty-eight healthy euthyroid dogs. METHODS: A prospective, randomized study administering levothyroxine to euthyroid dogs for 8 weeks (group 1) or 16 weeks (group 2)...
May 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28198040/blood-transfusions-in-dogs-and-cats-receiving-hemodialysis-230-cases-june-1997-september-2012
#3
C Langston, A Cook, A Eatroff, E Mitelberg, S Chalhoub
BACKGROUND: Multiple factors exist that contribute to anemia in dogs and cats receiving hemodialysis, can necessitate transfusion. OBJECTIVES: To describe blood product usage in dogs and cats with acute and chronic kidney disease that were treated with intermittent hemodialysis to determine risk factors associated with the requirement for blood product transfusion. ANIMALS: 83 cats and 147 dogs undergoing renal replacement therapy at the Animal Medical Center for acute or chronic kidney disease...
March 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28186645/occult-gastrointestinal-bleeding-is-a-common-finding-in-dogs-with-chronic-kidney-disease
#4
Leandro Z Crivellenti, Sofia Borin-Crivellenti, Kristi L Fertal, Catarina M Contin, Caroline M J Miranda, Aureo E Santana
BACKGROUND: The risk of occult gastrointestinal bleeding (OGIB) is known to be increased among human dialysis patients suffering from end-stage renal disease. However, there are no studies to date that investigate the incidence of OGIB in either dogs or people with chronic kidney disease (CKD), irrespective of dialysis. OBJECTIVES: The purpose of the study was to determine whether the incidence of OGIB is greater in dogs with CKD as compared to a control population, and if this pathology is associated with changes in serum variables related to iron metabolism...
February 10, 2017: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/28117946/clearance-of-plasma-ivermectin-with-single-pass-lipid-dialysis-in-2-dogs
#5
Leonel A Londoño, Gareth J Buckley, Luiz Bolfer, Carsten Bandt
OBJECTIVE: To describe the use of single pass lipid dialysis (SPLD) for treatment of ivermectin toxicosis in 2 Australian Shepherd dogs with the ABCB1-1Δ gene mutation. CASE SERIES SUMMARY: Two Australian Shepherd dogs were presented for treatment of ivermectin toxicosis. Dogs were initially treated with intravenous lipid emulsion and supportive care, without improvement of clinical signs. They both developed respiratory paralysis and required mechanical ventilation...
March 2017: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/27849101/-emergency-management-of-intoxications-in-the-dog-and-cat
#6
Esther Hassdenteufel, Hendrik Lehmann, Matthias Schneider, Andreas Moritz
Intoxications may lead to life-threatening emergencies. While stabilising the patient, therapy should focus on a rapid and effective elimination of the toxin. General measures for decontamination (gastrointestinal, dermal, ocular) aim to effectively decrease the absorption of the poisonous substance. Further classification of the substance and its properties can assist with the choice of specific treatment options, including dialysis and specific antidotal therapy. In recent years, treatment with lipid emulsions for enhanced elimination of lipophilic substances has become an important therapeutic option...
December 5, 2016: Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
https://www.readbyqxmd.com/read/27302674/pharmacokinetic-study-of-meropenem-in-healthy-beagle-dogs-receiving-intermittent-hemodialysis
#7
S Y Byun, J W Jeong, J H Choi, K P Lee, H Y Youn, H J Maeng, K H Song, T S Koo, K W Seo
Meropenem, a second carbapenem antimicrobial agent with a broad spectrum of activity, is used to treat sepsis and resistant-bacterial infections in veterinary medicine. The objective of this study was to identify the pharmacokinetics of meropenem in dogs receiving intermittent hemodialysis (IHD) and to determine the proper dosing in renal failure patients receiving IHD. Five healthy beagle dogs were given a single i.v. dose of 24 mg/kg of meropenem and received IHD. The blood flow rate, dialysate flow, and ultrafiltration rate were maintained at 40 mL/min, 300 mL/min, and 40 mL/h, respectively...
December 2016: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27283844/profile-of-disposition-tissue-distribution-and-excretion-of-the-novel-anti-human-immunodeficiency-virus-hiv-agent-w-1-in-rats
#8
Ying-Yuan Lu, Xiao-Wei Wang, Xin Wang, Wen-Bing Dai, Qiang Zhang, Pu Li, Ya-Qing Lou, Chuang Lu, Jun-Yi Liu, Guo-Liang Zhang
The purpose of this study was to characterize the disposition, distribution, excretion and plasma protein binding of 6-benzyl-1-benzyloxymethyl-5-iodouracil (W-1) in rats. Concentrations of W-1 within biological samples were determined using a validated high performance liquid chromatography method. The plasma protein binding of W-1 was examined by equilibrium dialysis method. After oral administration of W-1 (50, 100 and 200 mg/kg, respectively) in self-microemulsifying drug delivery system formulation, the pharmacokinetic parameters of W-1 were as follows: the peak plasma concentrations (C max) were 0...
July 2016: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/27019157/comparing-listeriosis-risks-in-at-risk-populations-using-a-user-friendly-quantitative-microbial-risk-assessment-tool-and-epidemiological-data
#9
COMPARATIVE STUDY
L E Falk, K A Fader, D S Cui, S C Totton, A M Fazil, A M Lammerding, B A Smith
Although infection by the pathogenic bacterium Listeria monocytogenes is relatively rare, consequences can be severe, with a high case-fatality rate in vulnerable populations. A quantitative, probabilistic risk assessment tool was developed to compare estimates of the number of invasive listeriosis cases in vulnerable Canadian subpopulations given consumption of contaminated ready-to-eat delicatessen meats and hot dogs, under various user-defined scenarios. The model incorporates variability and uncertainty through Monte Carlo simulation...
October 2016: Epidemiology and Infection
https://www.readbyqxmd.com/read/26840641/dog-ownership-status-and-self-assessed-health-life-style-and-habitual-physical-activity-in-chronic-hemodialysis-patients
#10
Magdalena Kuban, Jerzy Królikowski, Michał Nowicki
Introduction The Statement from the American Heart Association has emphasized a need for novel strategies that can reduce the risk of cardiovascular disease (CVD). Taking a dog for a walk forces its owner to take physical activity. Several studies have explored the relationship between pet ownership and CVD and most reported benefits. This issue has not been investigated in dialysis patients. The aim of the study was to analyze the influence of pet ownership on health and physical activity in hemodialysis patients...
July 2016: Hemodialysis International
https://www.readbyqxmd.com/read/26172197/effect-of-dialysis-of-dog-semen-on-sperm-characteristics-and-some-biochemical-components-of-seminal-plasma
#11
R Strzeżek, M Koziorowska-Gilun, K Kiełczewski, W Kordan
The aim of this study was to investigate the effect of dog semen dialysis on sperm characteristics and some biochemical components of seminal plasma. Whole ejaculates were dialyzed against Tris-citrate-fructose extender for a 5 h period at room temperature (using semi-permeable cellulose tubing of 12-14 kDa molecular weight cut-off). It has been demonstrated that the long-term dialysis of dog semen causes a significant decrease in sperm quality parameters and disrupts the biochemical properties of seminal plasma...
2015: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/26088982/enhancing-oral-bioavailability-of-quercetin-using-novel-soluplus-polymeric-micelles
#12
Linghui Dian, Enjiang Yu, Xiaona Chen, Xinguo Wen, Zhengzan Zhang, Lingzhen Qin, Qingqing Wang, Ge Li, Chuanbin Wu
To improve its poor aqueous solubility and stability, the potential chemotherapeutic drug quercetin was encapsulated in soluplus polymeric micelles by a modified film dispersion method. With the encapsulation efficiency over 90%, the quercetin-loaded polymeric micelles (Qu-PMs) with drug loading of 6.7% had a narrow size distribution around mean size of 79.00 ± 2.24 nm, suggesting the complete dispersibility of quercetin in water. X-ray diffraction (XRD) patterns illustrated that quercetin was in amorphous or molecular form within PMs...
December 2014: Nanoscale Research Letters
https://www.readbyqxmd.com/read/26070921/-suicide-attempt-by-means-of-phenobarbital-overdose-effective-treatment-with-continuous-veno-venous-hemodialysis
#13
M Ruhe, S Grautoff, J Kähler, T Pohle
A 68-year-old woman tried to commit suicide using phenobarbital, which was initially prescribed for her dog that suffered from seizures. At admission she was unconscious and ventilated. Five days of intensive care therapy did not improve her state of consciousness. Subsequent continuous veno-venous hemodialysis accelerated the elimination of phenobarbital compared to endogenous elimination by a factor of five. The patient survived without sequelae. Detailed history taking and well-timed indication for dialysis were crucial...
March 2016: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://www.readbyqxmd.com/read/25858585/free-thyroxine-concentrations-by-equilibrium-dialysis-and-chemiluminescent-immunoassays-in-13-hypothyroid-dogs-positive-for-thyroglobulin-antibody
#14
J F Randolph, S V Lamb, J L Cheraskin, B J Schanbacher, V J Salerno, K M Mack, J M Scarlett, N J Place
OBJECTIVE: To determine if concentrations of free thyroxine (FT4) measured by semi-automated chemiluminescent immunoassay (CLIA) correspond to FT4 determined by equilibrium dialysis (ED) in hypothyroid dogs positive for thyroglobulin antibody (TGA). ANIMALS: Thirteen TGA-positive dogs classified as hypothyroid based on subnormal FT4 concentrations by ED. METHODS: Qualitative assessment of canine TGA was performed using an enzyme-linked immunosorbent assay...
May 2015: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/25759730/evaluation-of-immunogenicity-of-novel-isoform-of-eg95-eg95-5g1-from-echinococcus-granulosus-in-balb-c-mice
#15
Majid Pirestani, Abdolhossein Dalimi, Shahabodin Sarvi, Nima Khoramabadi
BACKGROUND: Echinococcosis is a zoonotic parasitic disease of humans and various herbivorous domestic animals transmitted by the contact with domestic and wild carnivores, mainly dogs and foxes. The aim of this study is the production, purification and evaluation immunogenicity of new construction of EG95 protein. METHODS: The recombinant plasmid pET32-a+ used for Eg95 expression was constructed with the EG95 gene of Echinococcus granulosus fused with the thioredoxin tag...
October 2014: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/25537827/secondary-hyperparathyroidism-is-associated-with-pulmonary-hypertension-in-older-patients-with-chronic-kidney-disease-and-proteinuria
#16
Gultekin Genctoy, Serap Arikan, Olcay Gedik
PURPOSE: Hyperparathyroidism is associated with pulmonary vascular calcification and pulmonary hypertension (PH) in a chronic kidney failure dog model, and increased prevalence of PH and a PH-hyperparathyroidism relationship in pre-dialysis chronic kidney disease (CKD) and hemodialysis patients are reported. This study investigated the prevalence of PH and relationships between PH and metabolic abnormalities in patients with stage 1-4 proteinuria CKD. METHODS: One-hundred and ninety patients (mean age 61 ± 17...
February 2015: International Urology and Nephrology
https://www.readbyqxmd.com/read/25378925/enhancement-of-oral-bioavailability-of-cyclosporine-a-comparison-of-various-nanoscale-drug-delivery-systems
#17
Kai Wang, Jianping Qi, Tengfei Weng, Zhiqiang Tian, Yi Lu, Kaili Hu, Zongning Yin, Wei Wu
A variety of nanoscale delivery systems have been shown to enhance the oral absorption of poorly water-soluble and poorly permeable drugs. However, the performance of these systems has seldom been evaluated simultaneously. The aim of this study was to compare the bioavailability enhancement effect of lipid-based nanocarriers with poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) to highlight the importance of the lipid composition, with cyclosporine A (CyA) as a model drug. CyA-loaded PLGA NPs, nanostructured lipid carriers (NLCs), and self-microemulsifying drug-delivery systems (SMEDDS) were prepared...
2014: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/24438008/use-of-tissue-plasminogen-activator-in-catheters-used-for-extracorporeal-renal-replacement-therapy
#18
C Langston, A Eatroff, K Poeppel
BACKGROUND: Intraluminal thrombosis of central venous catheters used for renal replacement therapy (RRT) decreases the ability to provide adequate treatment. Alteplase is a recombinant tissue plasminogen activator that has been used to improve the function of catheters used for RRT in humans. OBJECTIVES: To retrospectively review alteplase instillation in dysfunctional catheters used for RRT in dogs and cats. ANIMALS: Seventeen dogs and 8 cats receiving RRT for kidney failure...
March 2014: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/24241343/stereoselective-binding-of-doxazosin-enantiomers-to-plasma-proteins-from-rats-dogs-and-humans-in-vitro
#19
Jia-an Sun, De-zhi Kong, Ya-qin Zhen, Qing Li, Wei Zhang, Jiang-hua Zhang, Zhi-wei Yin, Lei-ming Ren
AIM: (±)Doxazosin is a long-lasting inhibitor of α1-adrenoceptors that is widely used to treat benign prostatic hyperplasia and lower urinary tract symptoms. In this study we investigated the stereoselective binding of doxazosin enantiomers to the plasma proteins of rats, dogs and humans in vitro. METHODS: Human, dog and rat plasma were prepared. Equilibrium dialysis was used to determine the plasma protein binding of each enantiomer in vitro. Chiral HPLC with fluorescence detection was used to measure the drug concentrations on each side of the dialysis membrane bag...
December 2013: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/24040782/mycoplasma-edwardii-peritonitis-in-a-patient-on-maintenance-peritoneal-dialysis
#20
Shwetal P Lalan, Bradley A Warady, Douglas Blowey, Ken B Waites, Rangaraj Selvarangan
Mycoplasma edwardii (M. edwardii) is an anthropozoonotic microorganism found in the upper respiratory and urogenital tracts of dogs. M. edwardii was one of the microbes isolated from peritoneal fluid of a 10-year-old child diagnosed with polymicrobial peritonitis following a puncture of dialysis tubing by a pet dog. Other unique pathogens representative of canine oral microflora isolated from this patient on peritoneal dialysis were Kingella denitrificans, Actinomycetes species and Capnocytophaga cynodegmi.
January 2015: Clinical Nephrology
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