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Dog and dialysis

S Y Byun, J W Jeong, J H Choi, K P Lee, H Y Youn, H J Maeng, K H Song, T S Koo, K W Seo
Meropenem, a second carbapenem antimicrobial agent with a broad spectrum of activity, is used to treat sepsis and resistant-bacterial infections in veterinary medicine. The objective of this study was to identify the pharmacokinetics of meropenem in dogs receiving intermittent hemodialysis (IHD) and to determine the proper dosing in renal failure patients receiving IHD. Five healthy beagle dogs were given a single i.v. dose of 24 mg/kg of meropenem and received IHD. The blood flow rate, dialysate flow, and ultrafiltration rate were maintained at 40 mL/min, 300 mL/min, and 40 mL/h, respectively...
June 15, 2016: Journal of Veterinary Pharmacology and Therapeutics
Ying-Yuan Lu, Xiao-Wei Wang, Xin Wang, Wen-Bing Dai, Qiang Zhang, Pu Li, Ya-Qing Lou, Chuang Lu, Jun-Yi Liu, Guo-Liang Zhang
The purpose of this study was to characterize the disposition, distribution, excretion and plasma protein binding of 6-benzyl-1-benzyloxymethyl-5-iodouracil (W-1) in rats. Concentrations of W-1 within biological samples were determined using a validated high performance liquid chromatography method. The plasma protein binding of W-1 was examined by equilibrium dialysis method. After oral administration of W-1 (50, 100 and 200 mg/kg, respectively) in self-microemulsifying drug delivery system formulation, the pharmacokinetic parameters of W-1 were as follows: the peak plasma concentrations (C max) were 0...
July 2016: Archives of Pharmacal Research
L E Falk, K A Fader, D S Cui, S C Totton, A M Fazil, A M Lammerding, B A Smith
Although infection by the pathogenic bacterium Listeria monocytogenes is relatively rare, consequences can be severe, with a high case-fatality rate in vulnerable populations. A quantitative, probabilistic risk assessment tool was developed to compare estimates of the number of invasive listeriosis cases in vulnerable Canadian subpopulations given consumption of contaminated ready-to-eat delicatessen meats and hot dogs, under various user-defined scenarios. The model incorporates variability and uncertainty through Monte Carlo simulation...
October 2016: Epidemiology and Infection
Magdalena Kuban, Jerzy Królikowski, Michał Nowicki
Introduction The Statement from the American Heart Association has emphasized a need for novel strategies that can reduce the risk of cardiovascular disease (CVD). Taking a dog for a walk forces its owner to take physical activity. Several studies have explored the relationship between pet ownership and CVD and most reported benefits. This issue has not been investigated in dialysis patients. The aim of the study was to analyze the influence of pet ownership on health and physical activity in hemodialysis patients...
July 2016: Hemodialysis International
R Strzeżek, M Koziorowska-Gilun, K Kiełczewski, W Kordan
The aim of this study was to investigate the effect of dog semen dialysis on sperm characteristics and some biochemical components of seminal plasma. Whole ejaculates were dialyzed against Tris-citrate-fructose extender for a 5 h period at room temperature (using semi-permeable cellulose tubing of 12-14 kDa molecular weight cut-off). It has been demonstrated that the long-term dialysis of dog semen causes a significant decrease in sperm quality parameters and disrupts the biochemical properties of seminal plasma...
2015: Polish Journal of Veterinary Sciences
Linghui Dian, Enjiang Yu, Xiaona Chen, Xinguo Wen, Zhengzan Zhang, Lingzhen Qin, Qingqing Wang, Ge Li, Chuanbin Wu
To improve its poor aqueous solubility and stability, the potential chemotherapeutic drug quercetin was encapsulated in soluplus polymeric micelles by a modified film dispersion method. With the encapsulation efficiency over 90%, the quercetin-loaded polymeric micelles (Qu-PMs) with drug loading of 6.7% had a narrow size distribution around mean size of 79.00 ± 2.24 nm, suggesting the complete dispersibility of quercetin in water. X-ray diffraction (XRD) patterns illustrated that quercetin was in amorphous or molecular form within PMs...
December 2014: Nanoscale Research Letters
M Ruhe, S Grautoff, J Kähler, T Pohle
A 68-year-old woman tried to commit suicide using phenobarbital, which was initially prescribed for her dog that suffered from seizures. At admission she was unconscious and ventilated. Five days of intensive care therapy did not improve her state of consciousness. Subsequent continuous veno-venous hemodialysis accelerated the elimination of phenobarbital compared to endogenous elimination by a factor of five. The patient survived without sequelae. Detailed history taking and well-timed indication for dialysis were crucial...
March 2016: Medizinische Klinik, Intensivmedizin und Notfallmedizin
J F Randolph, S V Lamb, J L Cheraskin, B J Schanbacher, V J Salerno, K M Mack, J M Scarlett, N J Place
OBJECTIVE: To determine if concentrations of free thyroxine (FT4) measured by semi-automated chemiluminescent immunoassay (CLIA) correspond to FT4 determined by equilibrium dialysis (ED) in hypothyroid dogs positive for thyroglobulin antibody (TGA). ANIMALS: Thirteen TGA-positive dogs classified as hypothyroid based on subnormal FT4 concentrations by ED. METHODS: Qualitative assessment of canine TGA was performed using an enzyme-linked immunosorbent assay...
May 2015: Journal of Veterinary Internal Medicine
Majid Pirestani, Abdolhossein Dalimi, Shahabodin Sarvi, Nima Khoramabadi
BACKGROUND: Echinococcosis is a zoonotic parasitic disease of humans and various herbivorous domestic animals transmitted by the contact with domestic and wild carnivores, mainly dogs and foxes. The aim of this study is the production, purification and evaluation immunogenicity of new construction of EG95 protein. METHODS: The recombinant plasmid pET32-a+ used for Eg95 expression was constructed with the EG95 gene of Echinococcus granulosus fused with the thioredoxin tag...
October 2014: Iranian Journal of Parasitology
Gultekin Genctoy, Serap Arikan, Olcay Gedik
PURPOSE: Hyperparathyroidism is associated with pulmonary vascular calcification and pulmonary hypertension (PH) in a chronic kidney failure dog model, and increased prevalence of PH and a PH-hyperparathyroidism relationship in pre-dialysis chronic kidney disease (CKD) and hemodialysis patients are reported. This study investigated the prevalence of PH and relationships between PH and metabolic abnormalities in patients with stage 1-4 proteinuria CKD. METHODS: One-hundred and ninety patients (mean age 61 ± 17...
February 2015: International Urology and Nephrology
Kai Wang, Jianping Qi, Tengfei Weng, Zhiqiang Tian, Yi Lu, Kaili Hu, Zongning Yin, Wei Wu
A variety of nanoscale delivery systems have been shown to enhance the oral absorption of poorly water-soluble and poorly permeable drugs. However, the performance of these systems has seldom been evaluated simultaneously. The aim of this study was to compare the bioavailability enhancement effect of lipid-based nanocarriers with poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) to highlight the importance of the lipid composition, with cyclosporine A (CyA) as a model drug. CyA-loaded PLGA NPs, nanostructured lipid carriers (NLCs), and self-microemulsifying drug-delivery systems (SMEDDS) were prepared...
2014: International Journal of Nanomedicine
C Langston, A Eatroff, K Poeppel
BACKGROUND: Intraluminal thrombosis of central venous catheters used for renal replacement therapy (RRT) decreases the ability to provide adequate treatment. Alteplase is a recombinant tissue plasminogen activator that has been used to improve the function of catheters used for RRT in humans. OBJECTIVES: To retrospectively review alteplase instillation in dysfunctional catheters used for RRT in dogs and cats. ANIMALS: Seventeen dogs and 8 cats receiving RRT for kidney failure...
March 2014: Journal of Veterinary Internal Medicine
Jia-an Sun, De-zhi Kong, Ya-qin Zhen, Qing Li, Wei Zhang, Jiang-hua Zhang, Zhi-wei Yin, Lei-ming Ren
AIM: (±)Doxazosin is a long-lasting inhibitor of α1-adrenoceptors that is widely used to treat benign prostatic hyperplasia and lower urinary tract symptoms. In this study we investigated the stereoselective binding of doxazosin enantiomers to the plasma proteins of rats, dogs and humans in vitro. METHODS: Human, dog and rat plasma were prepared. Equilibrium dialysis was used to determine the plasma protein binding of each enantiomer in vitro. Chiral HPLC with fluorescence detection was used to measure the drug concentrations on each side of the dialysis membrane bag...
December 2013: Acta Pharmacologica Sinica
Shwetal P Lalan, Bradley A Warady, Douglas Blowey, Ken B Waites, Rangaraj Selvarangan
Mycoplasma edwardii (M. edwardii) is an anthropozoonotic microorganism found in the upper respiratory and urogenital tracts of dogs. M. edwardii was one of the microbes isolated from peritoneal fluid of a 10-year-old child diagnosed with polymicrobial peritonitis following a puncture of dialysis tubing by a pet dog. Other unique pathogens representative of canine oral microflora isolated from this patient on peritoneal dialysis were Kingella denitrificans, Actinomycetes species and Capnocytophaga cynodegmi.
January 2015: Clinical Nephrology
Katy Bradford, Jim Meinkoth, Kelci McKeirnen, Brenda Love
Candida peritonitis is reported in people and is associated with significant morbidity and mortality compared with sterile or bacterial peritonitis. Recognized predisposing risk factors include peritoneal dialysis, hollow viscous organ perforation, abdominal surgery, inflamed intestinal mucosa, antimicrobial administration, and immunosuppression. In this report, we describe 5 cases of dogs with peritonitis complicated by Candida spp; 3 dogs with C albicans, one dog with C albicans and C glabrata, and one dog with C glabrata only...
June 2013: Veterinary Clinical Pathology
Linda A Ross, Mary Anna Labato
OBJECTIVE: To provide a current overview of the technique of peritoneal dialysis in dogs and cats. CLINICAL IMPLICATION: Peritoneal dialysis is the process by which water and solutes move between blood in the peritoneal capillaries and fluid (dialysate) instilled into the peritoneal cavity, across the semipermeable membrane of the peritoneum. The primary indication for peritoneal dialysis (PD) in animals is for treatment of renal failure to correct water, solute, and acid-base abnormalities and to remove uremic toxins...
March 2013: Journal of Veterinary Emergency and Critical Care
Jennifer R Stafford, Joseph W Bartges
OBJECTIVE: To review current literature regarding uroabdomen in dogs and cats with respect to etiology, diagnostic approach, medical and surgical treatment, and prognosis. ETIOLOGY: Uroabdomen in dogs and cats is most often associated with vehicular or blunt trauma. This condition may also result from urinary tract obstruction, traumatic bladder expression or catheterization, neoplasia, and postoperative leakage following abdominal or urogenital surgery. DIAGNOSIS: Disruption to the urinary tract should be considered when a patient is diagnosed with azotemia, hyperkalemia, and abdominal effusion...
March 2013: Journal of Veterinary Emergency and Critical Care
Gilles Dupré, Karel Čoudek
OBJECTIVE: To describe a technique of laparoscopic-assisted placement of a peritoneal dialysis (PD) catheter with simultaneously performed partial omentectomy and omentopexy. STUDY DESIGN: Pilot experimental study. ANIMALS: Beagle dogs (n = 6). METHODS: After placement of 1 sub-umbilical laparoscope portal and 1 instrument portal in the left cranial abdominal quadrant, laparoscopic-assisted partial omentectomy, and omentopexy were performed, and a modified Tenckhoff PD catheter was placed under laparoscopic guidance...
June 2013: Veterinary Surgery: VS
A Samoylov, N Cox, A Cochran, K Wolfe, C Donovan, M Kutzler, V Petrenko, H Baker, T Samoylova
Overpopulation of cats and dogs is a serious worldwide problem that demands novel, safe and cost-effective solutions. The objective of this study was to generate and characterize phage-peptide conjugates with gonadotropin-releasing hormone (GnRH) for potential use as an immunocontraceptive. A filamentous phage vector f5-8 with wild-type phage coat proteins was used as a carrier for construction of chemical conjugates with GnRH, a peptide that acts as a master reproductive hormone. In such conjugates, the phage body plays the role of a carrier protein, while multiple copies of GnRH peptide stimulate production of neutralizing anti-GnRH antibodies potentially leading to contraceptive effects...
December 2012: Reproduction in Domestic Animals, Zuchthygiene
Wei Cao, Yan Chen, Ling Yuan, Jun-Jie He
The aim of this paper is to report the development of a method for the determination of the binding rates of cinobufagin (CBG) and resibufogenin (RBG) with different plasma proteins. Equilibrium dialysis method was used to imitate the binding process between cinobufagin, resibufogenin and plasma proteins. HPLC was employed to determine the concentration of cinobufagin and resibufogenin inside and outside of the dialysis membrane, and then on the basis of which protein binding rates were calculated. The calibration curves of both cinobufagin and resibufogenin with human, rats' and Beagle dogs' plasma were linear in the range of 0...
September 2012: Yao Xue Xue Bao, Acta Pharmaceutica Sinica
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