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https://www.readbyqxmd.com/read/28330041/retinal-tractography-influence-of-diffusion-acquisition-ocular-laterality-and-ocular-dominance-in-healthy-subjects
#1
Clément Jean, Arnaud Attyé, Sylvie Grand, Augustin Lecler, Christophe Chiquet, Florent Aptel, Laurent Lamalle, Alexandre Krainik
PURPOSE: Exploration of the human retina has never been described with MRI tractography, supposedly because of ocular movement-related artifacts and imaging distortions with EPI diffusion acquisition. In this work, we used track-weighting imaging to assess retinal fascicles. Diffusion acquisition parameters influence was studied and the relationship between variability and ocular laterality and ocular dominance was explored. MATERIALS AND METHODS: Twenty healthy subjects underwent MRI, with retinal tractography calculated with the constrained spherical deconvolution model...
March 2017: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/28329857/-play-and-people-living-with-dementia-a-humanities-based-inquiry-of-timeslips-and-the-alzheimer-s-poetry-project
#2
Aagje Swinnen, Kate de Medeiros
This paper is a humanities-based inquiry, applying Huizinga's framework of homo ludens ("man the player") to consider "play" in the context of two participatory arts programs (TimeSlips and the Alzheimer's Poetry Project) for people living with dementia. "Play," according to this Dutch historian, is at the heart of human activity and what gives meaning to life. Despite empirical research on play across the life course, play in dementia care is a relatively new idea. In addition, there is a dearth of reports based on humanistic inquiry which has slightly different goals than the growing body of qualitative and quantitative studies of participatory arts interventions...
January 18, 2017: Gerontologist
https://www.readbyqxmd.com/read/28329771/capacity-shortfalls-hinder-the-performance-of-marine-protected-areas-globally
#3
David A Gill, Michael B Mascia, Gabby N Ahmadia, Louise Glew, Sarah E Lester, Megan Barnes, Ian Craigie, Emily S Darling, Christopher M Free, Jonas Geldmann, Susie Holst, Olaf P Jensen, Alan T White, Xavier Basurto, Lauren Coad, Ruth D Gates, Greg Guannel, Peter J Mumby, Hannah Thomas, Sarah Whitmee, Stephen Woodley, Helen E Fox
Marine protected areas (MPAs) are increasingly being used globally to conserve marine resources. However, whether many MPAs are being effectively and equitably managed, and how MPA management influences substantive outcomes remain unknown. We developed a global database of management and fish population data (433 and 218 MPAs, respectively) to assess: MPA management processes; the effects of MPAs on fish populations; and relationships between management processes and ecological effects. Here we report that many MPAs failed to meet thresholds for effective and equitable management processes, with widespread shortfalls in staff and financial resources...
March 22, 2017: Nature
https://www.readbyqxmd.com/read/28329069/giardiasis-and-subsequent-irritable-bowel-syndrome-a-longitudinal-cohort-study-using-health-insurance-data
#4
Jolene H Nakao, Sarah A Collier, Julia W Gargano
Background.: Giardia intestinalis is the most commonly reported human intestinal parasite in the United States. Increased incidence of chronic gastrointestinal complaints has been reported after some giardiasis outbreaks. We examined the relationship between giardiasis diagnosis and irritable bowel syndrome (IBS) diagnosis. Methods.: We used the 2006-2010 MarketScan commercial insurance database. Persons with at least 1 giardiasis diagnosis were individually matched on age group, sex, and enrollment length in months to 5 persons without a giardiasis diagnosis...
February 23, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28329042/longitudinal-cardiovascular-outcomes-of-sleep-disordered-breathing-in-children-a-meta-analysis-and-systematic-review
#5
Zarmina Ehsan, Stacey L Ishman, Thomas R Kimball, Nanhua Zhang, Yuanshu Zou, Raouf S Amin
Objectives: The presence of sleep disordered breathing (SDB) is known to impact long-term cardiovascular morbidity in adults; however, the long-term effects in children are poorly understood. We aimed to systematically review and synthesize studies published to date on the long-term effects of SDB in children. Study Design: Meta-analysis and systematic review using PubMed, CINAHL,Embase and Scopus (all indexed years). Methods: We searched for English-language articles containing original human data from prospective studies, with ≥7 participants, in children ≤18 years of age...
January 28, 2017: Sleep
https://www.readbyqxmd.com/read/28329018/a-unique-microrna-profile-in-end-stage-heart-failure-indicates-alterations-in-specific-cardiovascular-signaling-networks
#6
Sathyamangla V Naga Prasad, Manveen K Gupta, Zhong-Hui Duan, Venkata Suresh K Surampudi, Chang-Gong Liu, Ashwin Kotwal, Christine S Moravec, Randall C Starling, Dianne M Perez, Subha Sen, Qingyu Wu, Edward F Plow, Sadashiva Karnik
It is well established that the gene expression patterns are substantially altered in cardiac hypertrophy and heart failure, however, less is known about the reasons behind such global differences. MicroRNAs (miRNAs) are short non-coding RNAs that can target multiple molecules to regulate wide array of proteins in diverse pathways. The goal of the study was to profile alterations in miRNA expression using end-stage human heart failure samples with an aim to build signaling network pathways using predicted targets for the altered miRNA and to determine nodal molecules regulating individual networks...
2017: PloS One
https://www.readbyqxmd.com/read/28328948/vascular-endothelial-overexpression-of-human-cyp2j2-tie2-cyp2j2-tr-modulates-cardiac-oxylipin-profiles-and-enhances-coronary-reactive-hyperemia-in-mice
#7
Ahmad Hanif, Matthew L Edin, Darryl C Zeldin, Christophe Morisseau, John R Falck, Mohammed A Nayeem
Arachidonic acid is metabolized to epoxyeicosatrienoic acids (EETs) by cytochrome (CYP) P450 epoxygenases, and to ω-terminal hydroxyeicosatetraenoic acids (HETEs) by ω-hydroxylases. EETs and HETEs often have opposite biologic effects; EETs are vasodilatory and protect against ischemia/reperfusion injury, while ω-terminal HETEs are vasoconstrictive and cause vascular dysfunction. Other oxylipins, such as epoxyoctadecaenoic acids (EpOMEs), hydroxyoctadecadienoic acids (HODEs), and prostanoids also have varied vascular effects...
2017: PloS One
https://www.readbyqxmd.com/read/28328655/vascularized-composite-allotransplantation-an-emerging-concept-for-burn-reconstruction
#8
Zhi Yang Ng, Alexandre G Lellouch, Tessa Drijkoningen, Irene A Chang, David H Sachs, Curtis L Cetrulo
Vascularized composite allotransplantation (VCA) has demonstrated utility in the reconstruction of extensive soft-tissue defects following severe burns. However, pre-VCA events such as multiple transfusions, previous transplantation and pregnancies, the use of skin allografts, and mechanical support devices may result in sensitization and ultimately exclude a burn patient, who may benefit most through VCA, from a hand or face transplant. The authors sought to identify the immunologic challenges involved. All reported VCA cases up to July 2016 were reviewed...
March 15, 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/28328552/il-1%C3%AE-levels-are-associated-with-chronic-multisite-pain-in-people-living-with-hiv
#9
Jessica S Merlin, Andrew O Westfall, Sonya L Heath, Burel R Goodin, Jesse C Stewart, Robert E Sorge, Jarred Younger
BACKGROUND: The pathophysiology of chronic pain experienced by people living with HIV (PLWH) in the current antiretroviral treatment era is poorly understood. We sought to investigate the relationship between inflammation and chronic pain in PLWH. We hypothesized that, among PLWH who have undetectable HIV viral loads, those with Chronic Multisite Pain (CMP) would have higher levels of circulating pain-related inflammatory markers than those without chronic pain. SETTING: This study was conducted at the University of Alabama at Birmingham's Center for AIDS Research Network of Integrated Clinical System (CNICS) site...
March 20, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28328303/the-role-of-pain-in-quitting-among-human-immunodeficiency-virus-hiv-positive-smokers-enrolled-in-a-smoking-cessation-trial
#10
Carrie J Aigner, Ellen R Gritz, Irene Tamí-Maury, George P Baum, Roberto C Arduino, Damon J Vidrine
BACKGROUND: Smoking rates among people living with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS; PLWHA) are at least twice as high as rates in the general population. Consistent with the reciprocal model of pain and smoking, PLWHA with pain who smoke may use smoking as a means of coping with pain, thus presenting a potential barrier to quitting. The aim of this study is to better understand how pain relates to smoking cessation among 474 HIV-positive adults enrolled in a cell phone-delivered smoking cessation trial...
February 8, 2017: Substance Abuse
https://www.readbyqxmd.com/read/28327985/the-need-to-approximate-the-use-case-in-clinical-machine-learning
#11
Sohrab Saeb, Luca Lonini, Arun Jayaraman, David C Mohr, Konrad P Kording
Background: The availability of smartphone and wearable sensor technology is leading to a rapid accumulation of human subject data, and machine learning is emerging as a technique to map that data into clinical predictions. As machine learning algorithms are increasingly used to support clinical decision making, it is vital to reliably quantify their prediction accuracy. Cross-validation is the standard approach where the accuracy of such algorithms is evaluated on data the algorithm has not seen during training...
March 15, 2017: GigaScience
https://www.readbyqxmd.com/read/28327540/endocrine-disrupting-chemicals-and-endometrial-cancer-an-overview-of-recent-laboratory-evidence-and-epidemiological-studies
#12
REVIEW
Maddalena Mallozzi, Chiara Leone, Francesca Manurita, Filippo Bellati, Donatella Caserta
Background: Although exposure to endocrine disruptor compounds (EDCs) has been suggested as a contributing factor to a range of women's health disorders including infertility, polycystic ovaries and the early onset of puberty, considerable challenges remain in attributing cause and effect on gynaecological cancer. Until recently, there were relatively few epidemiological studies examining the relationship between EDCs and endometrial cancer, however, in the last years the number of these studies has increased...
March 22, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28327441/structure-based-design-synthesis-and-biological-evaluation-of-amino-phosphonate-derivatives-as-human-glucokinase-activators
#13
Nanda Kumar Yellapu, Ravendra Babu Kilaru, Nagaraju Chamarthi, Sarma Pvgk, Bhaskar Matcha
Glucokinase (GK) is a potential therapeutic target of type 2 diabetes and GK activators (GKAs) represent a promising class of small organic molecules which enhance GK activity. Based on the configuration and conformation of the allosteric site of GK, we have designed a novel class of amino phosphonate derivatives in order to develop potent GKAs. The QSAR model developed using numerous descriptors revealed its potential with the best effective statistical values of RMSE=1.52 and r(2)=0.30. Moreover, application of this model on the present test set GKAs proved to be worthy to predict their activities as a better linear relationship was observed with RMSE=0...
March 2, 2017: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/28327437/evaluating-the-effect-of-antioxidant-agents-on-shear-bond-strength-of-tooth-colored-restorative-materials-after-bleaching-a-systematic-review
#14
REVIEW
Atiyeh Feiz, Hamid Mosleh, Rahman Nazeri
PURPOSE: The main objective of the present study was to make a systematic review of how antioxidant agents affect shear bond strength of tooth-colored restorative materials after bleaching. DATA SOURCES: Electronic search was used to extract the related articles on the targeted key words such as "antioxidant", "dental bleaching" and "shear bond strength" (SBS) from MeSH, PubMed, Medline, and Cochrane electronic data bases. These articles were all published before 2016...
March 10, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28327364/telomere-length-analysis-in-down-syndrome-birth
#15
Pranami Bhaumik, Mandar Bhattacharya, Priyanka Ghosh, Sujoy Ghosh, Subrata Kumar Dey
Human reproductive fitness depends upon telomere chemistry. Maternal age, meiotic nondisjunction error and telomere length of mother of trisomic child are someway associated. Reports exhibiting maternal inheritance of telomere length in Down syndrome child are very scanty. To investigate this, we collected peripheral blood from 170 mothers of Down syndrome child and 186 age matched mothers of euploid child with their newly born babies. Telomere length was measured by restriction digestion - southern blotting technique...
March 19, 2017: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/28327132/simultaneous-analysis-of-mirna-mrna-in-human-meningiomas-by-integrating-transcriptome-a-relationship-between-ptx3-and-mir-29c
#16
Altay Burak Dalan, Sukru Gulluoglu, Emre Can Tuysuz, Aysegul Kuskucu, Cumhur Kaan Yaltirik, Oguz Ozturk, Ugur Ture, Omer Faruk Bayrak
BACKGROUND: Although meningioma is a common disease, there is a lack of understanding of the underlying molecular mechanisms behind its initiation and progression. We used combined miRNA-mRNA transcriptome analysis to discover dysregulated genes and networks in meningiomas. METHODS: Fourteen fresh-frozen meningioma samples and one human meningeal cell line were analyzed by using miRNA and whole transcriptome microarray chips. Data was filtered and analyzed. Candidate miRNAs and mRNAs were selected for validation in fifty-eight patient samples...
March 21, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28326980/gene-sequence-analyses-of-the-healthy-oral-microbiome-in-humans-and-companion-animals
#17
Eric M Davis
It has long been accepted that certain oral bacterial species are responsible for the development of periodontal disease. However, the focus of microbial and immunological research is shifting from studying the organisms associated with disease to examining the indigenous microbial inhabitants that are present in health. Microbiome refers to the aggregate genetic material of all microorganisms living in, or on, a defined habitat. Recent developments in gene sequence analysis have enabled detection and identification of bacteria from polymicrobial samples, including subgingival plaque...
June 2016: Journal of Veterinary Dentistry
https://www.readbyqxmd.com/read/28326591/arbitrarily-applicable-spatial-relational-responding
#18
Richard J May, Ian Stewart, Luisa Baez, Gary Freegard, Simon Dymond
Spatial reasoning, where novel spatial relationships are inferred based on trained relationships, can be conceptualized as arbitrarily applicable spatial relational responding. Here, we conducted two experiments to develop and validate, for the first time, a laboratory procedure to establish arbitrarily applicable spatial relational responding in adult humans. In Experiment 1, participants were trained on nonarbitrary spatial relational tasks designed to establish contextual cues for left of, right of, above, and below...
March 2017: Journal of the Experimental Analysis of Behavior
https://www.readbyqxmd.com/read/28326452/methyleugenol-dna-adducts-in-human-liver-are-associated-with-sult1a1-copy-number-variations-and-expression-levels
#19
Roman Tremmel, Kristin Herrmann, Wolfram Engst, Walter Meinl, Kathrin Klein, Hansruedi Glatt, Ulrich M Zanger
Methyleugenol is a rodent hepatocarcinogen occurring in many herbs and spices as well as essential oils used for flavoring. Following metabolic activation by cytochromes P450 (CYPs) and sulfotransferases (SULTs), methyleugenol can form DNA adducts. Previously, we showed that DNA adduct formation by methyleugenol in mouse liver is dependent on SULT1A1 expression and that methyleugenol DNA adducts are abundant in human liver specimens. In humans, SULT1A1 activity is affected by genetic polymorphisms, including single-nucleotide polymorphisms (SNPs) and copy number variations (CNVs)...
March 22, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28326326/genetic-analysis-of-two-chicken-infectious-anemia-virus-variants-related-gyrovirus-in-stray-mice-and-dogs-the-first-report-in-china-2015
#20
Lichun Fang, Yang Li, Yixin Wang, Jiayuan Fu, Shuai Cui, Xiaohan Li, Shuang Chang, Peng Zhao
Chicken infectious anemia virus (CIAV) causes acute viral infection in chickens worldwide. It can infect chickens of all ages, but the disease is seen only in young chickens and is characterized by hemorrhagic lesions in the muscles, atrophic changes in the lymphoid organs, aplastic bone marrow, and immunosuppression causing increased mortality. Previous studies have demonstrated that CIAV can be isolated from blood specimens of humans and fecal samples of stray cats. In the present study, two variants of CIAV were isolated from fecal samples of mice (CIAV-Mouse) and stray dogs (CIAV-Dog), respectively...
2017: BioMed Research International
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