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https://www.readbyqxmd.com/read/28432924/bringing-a-novel-to-practice-an-interpretive-study-of-reading-a-novel-in-an-undergraduate-nursing-practicum-course
#1
Graham McCaffrey, Lorraine Venturato, J David Patterson, Jennifer Langille, Roberta Jackson, Tom Rosenal
Novels are one humanities resource available to educators in health disciplines to support student reflection on their own professional practice and therapeutic relationships with patients. An interdisciplinary team, including nurses, a physician, and an English instructor, carried out an interpretive study of the use of a novel by clinical nursing instructors in an undergraduate practicum course. Students placed in assisted living or long term care facilities for the elderly were expected to read a contemporary work, Exit Lines, by Joan Barfoot, which is set in a comparable facility...
April 4, 2017: Nurse Education in Practice
https://www.readbyqxmd.com/read/28432829/trabecular-mapping-leveraging-geometric-morphometrics-for-analyses-of-trabecular-structure
#2
Adam D Sylvester, Claire E Terhune
OBJECTIVES: Trabecular microstructure of limb bone epiphyses has been used to elucidate the relationship between skeletal form and behavior among mammals. Such studies have often relied on the analysis of a single volume of interest (VOI). Here we present a method for evaluating variation in bone microstructure across articular surfaces by leveraging sliding semilandmarks. METHODS: Two samples were used to demonstrate the proposed methodology and test the hypothesis that microstructural variables are homogeneously distributed: tali from two ape genera (Pan and Pongo, n = 9) and modern human distal femora (n = 10)...
April 22, 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/28432704/human-galectin-9-on-the-porcine-cells-affects-the-cytotoxic-activity-of-m1-differentiated-thp-1-cells-through-inducing-a-shift-in-m2-differentiated-thp-1-cells
#3
Sung Han Jung, Jeong Ho Hwang, Sang Eun Kim, Young Kyu Kim, Hyo Chang Park, Hoon Taek Lee
BACKGROUND: In xenotransplantation, immune rejection by macrophages occurs rapidly and remains a major obstacle. Studies to control immune rejection in macrophages have been continuing to date. Recent studies have reported that human galectin-9 (hGal-9) can regulate the function of regulatory T cells (Treg), as well as cytotoxicity T cells (CTL) and natural killer cells (NK). Although the effect of hGal-9 on lymphocytes has been well studied, the relationship between hGal-9 and myeloid cells has been scarcely studied...
April 21, 2017: Xenotransplantation
https://www.readbyqxmd.com/read/28432591/prior-beliefs-influence-symmetrical-or-asymmetrical-generalizations-in-human-causal-learning
#4
Ryoji Nishiyama, Takatoshi Nagaishi, Takahisa Masaki
The generalization decrement between element A and compound AX has shown both symmetrical (Thorwart & Lachnit, 2009) and asymmetrical (Glautier, 2004) patterns in human contingency learning. In a series of experiments we examined the hypothesis that prior beliefs about the relationship between a distinctive element X and an outcome are important for determining the different generalization patterns. Participants learned which given enterobacteria caused a negative or a positive effect on gastrointestinal conditions...
April 21, 2017: Learning & Behavior
https://www.readbyqxmd.com/read/28432487/sodium-hydrogen-exchanger%C3%A2-expression-in-human-sperm-and-its-relationship-with-semen-parameters
#5
Zhe Zhang, Yuzhuo Yang, Han Wu, Hongliang Zhang, Haitao Zhang, Jiaming Mao, Defeng Liu, Lianming Zhao, Haocheng Lin, Wenhao Tang, Kai Hong, Hui Jiang
PURPOSE: Sperm-specific sodium-hydrogen exchanger (sNHE) is essential to maintain sperm normal function in mice; however, its role in human sperm has not been clarified to date. The aim of this study is to investigate the expression pattern of sNHE in human spermatozoa and its relationship with sperm functional parameters. METHOD: Semen samples from 68 asthenozoospermic and 61 normozoospermic men were analyzed for sperm concentration, motility, and acrosome reaction, and high motile spermatozoa were collected by swim-up method...
April 21, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28432057/imaging-and-modeling-of-acute-pressure-induced-changes-of-collagen-and-elastin-microarchitectures-in-pig-and-human-resistance-arteries
#6
Maria Bloksgaard, Thomas M Leurgans, Bart Spronck, Maarten Hg Heusinkveld, Bjarne Thorsted, Kristoffer Rosenstand, Inger Nissen, Ulla Melchior Hansen, Jonathan R Brewer, Luis A Bagatolli, Lars M Rasmussen, Akhmadjon Irmukhamedov, Koen D Reesink, Jo G R De Mey
The impact of disease related changes in the extracellular matrix (ECM) on the mechanical properties of human resistance arteries largely remains to be established. Resistance arteries from both pig and human parietal pericardium (PRA) display a different ECM microarchitecture compared to frequently used rodent mesenteric arteries. We hypothesized that the biaxial mechanics of PRA mirror pressure induced changes in the ECM microarchitecture. This was tested using isolated pig PRA as model system, integrating vital imaging, pressure myography and mathematical modeling...
April 21, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28431905/dynamic-interhemispheric-competition-and-vestibulo-cortical-control-in-humans-a-theoretical-proposition
#7
REVIEW
Qadeer Arshad
Neuroscientific research has made a concerted effort to determine cortical localisation using various functional imaging techniques. This approach has undoubtedly yielded important novel anatomical knowledge, albeit at times contradictory, regarding the structural organisation of the vestibular cortex. Unfortunately however, this knowledge has not translated to our understanding regarding how neural mechanisms control vestibular function. Based upon recent functional imaging, lesion and neuro-physiological data that has demonstrated (i) the close behavioural and neuro-anatomical relationship between cortical processing of vestibular and spatial attention signals, and (ii) that inducing interhemispheric competition can in-turn strongly modulate vestibular function akin to that observed in cortical lesion patients, I herewith propose the hypothesis that vestibular cortical processing is controlled, as per for spatial attention, via dynamic interhemispheric competition...
April 18, 2017: Neuroscience
https://www.readbyqxmd.com/read/28431455/uhplc-q-tof-ms-ms-based-screening-and-characterization-of-metabolites-of-cnidilin-in-human-liver-microsomes
#8
Lin Yuan, Yuqian Zhang, Man Liao, Yanyan Liu, Changchen Wan, Lantong Zhang
Cnidilin is an active natural furocoumarin ingredient originating from well-known traditional Chinese medicine Radix Angelicae dahuricae. In the present study, an efficient approach was developed for the screening and identification of cnidilin metabolites using ultra-high performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry. In this approach, an on-line data acquisition method multiple mass defect filter (MMDF) combined with dynamic background subtraction was developed to trace all probable metabolites...
April 21, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28431264/intercomparison-of-methods-to-estimate-black-carbon-emissions-from-cookstoves
#9
Candela de la Sota, Moustapha Kane, Javier Mazorra, Julio Lumbreras, Issakha Youm, Mar Viana
Black carbon is the second largest contributor to climate change and also poses risks to human health. Despite the need for black carbon (BC) emissions estimates from residential biomass burning for cooking, quantitative data are still scarce. This scarcity is mainly due to the scattered location of the stoves, as well as relatively costly and complex analytical methods available. Two low cost and easy-to-use optical methods, a cell-phone based system and smoke stain reflectometry, where compared to elemental carbon (EC) concentrations by the Sunset OCEC Analyzer (TOT)...
April 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28431252/engineered-regulatory-systems-modulate-gene-expression-of-human-commensals-in-the-gut
#10
Bentley Lim, Michael Zimmermann, Natasha A Barry, Andrew L Goodman
The gut microbiota is implicated in numerous aspects of health and disease, but dissecting these connections is challenging because genetic tools for gut anaerobes are limited. Inducible promoters are particularly valuable tools because these platforms allow real-time analysis of the contribution of microbiome gene products to community assembly, host physiology, and disease. We developed a panel of tunable expression platforms for the prominent genus Bacteroides in which gene expression is controlled by a synthetic inducer...
April 20, 2017: Cell
https://www.readbyqxmd.com/read/28431192/a-personal-connection-promoting-positive-attitudes-towards-teaching-and-learning
#11
Heidi L Lujan, Stephen E DiCarlo
Students' attitudes towards teaching and learning must be addressed with the same seriousness and effort as we address content. Establishing a personal connection and addressing our students' basic psychological needs will produce positive attitudes towards teaching and learning and develop life-long learners. It will also promote constructive student-teacher relationships that have a profound influence on our students' approach towards school. To begin this process, consider the major tenets of the Self-Determination Theory...
April 21, 2017: Anatomical Sciences Education
https://www.readbyqxmd.com/read/28431000/left-brain-asymmetry-of-the-planum-temporale-in-a-nonhominid-primate-redefining-the-origin-of-brain-specialization-for-language
#12
Damien Marie, Muriel Roth, Romain Lacoste, Bruno Nazarian, Alice Bertello, Jean-Luc Anton, William D Hopkins, Konstantina Margiotoudi, Scott A Love, Adrien Meguerditchian
The planum temporale (PT) is a critical region of the language functional network in the human brain showing a striking size asymmetry toward the left hemisphere. Historically considered as a structural landmark of the left-brain specialization for language, a similar anatomical bias has been described in great apes but never in monkeys-indicating that this brain landmark might be unique to Hominidae evolution. In the present in vivo magnetic resonance imaging study, we show clearly for the first time in a nonhominid primate species, an Old World monkey, a left size predominance of the PT among 96 olive baboons (Papio anubis), using manual delineation of this region in each individual hemisphere...
April 19, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28430812/nacl-cotransporter-abundance-in-urinary-vesicles-is-increased-by-calcineurin-inhibitors-and-predicts-thiazide-sensitivity
#13
Omar A Z Tutakhel, Arthur D Moes, Marco A Valdez-Flores, Marleen L A Kortenoeven, Mathijs V D Vrie, Sabina Jeleń, Robert A Fenton, Robert Zietse, Joost G J Hoenderop, Ewout J Hoorn, Luuk Hilbrands, René J M Bindels
Animal studies have shown that the calcineurin inhibitors (CNIs) cyclosporine and tacrolimus can activate the thiazide-sensitive NaCl cotransporter (NCC). A common side effect of CNIs is hypertension. Renal salt transporters such as NCC are excreted in urinary extracellular vesicles (uEVs) after internalization into multivesicular bodies. Human studies indicate that CNIs also increase NCC abundance in uEVs, but results are conflicting and no relationship with NCC function has been shown. Therefore, we investigated the effects of CsA and Tac on the abundance of both total NCC (tNCC) and phosphorylated NCC at Thr60 phosphorylation site (pNCC) in uEVs, and assessed whether NCC abundance in uEVs predicts the blood pressure response to thiazide diuretics...
2017: PloS One
https://www.readbyqxmd.com/read/28430100/discovery-of-african-bat-polyomaviruses-and-infrequent-recombination-in-the-large-t-antigen-in-the-polyomaviridae
#14
Michael Carr, Gabriel Gonzalez, Michihito Sasaki, Kimihito Ito, Akihiro Ishii, Bernard M Hang'ombe, Aaron S Mweene, Yasuko Orba, Hirofumi Sawa
Bat species represent natural reservoirs for a number of high-consequence human pathogens. The present study investigated the diversity of polyomaviruses (PyVs) in Zambian insectivorous and fruit bat species. We describe the complete genomes from four newly proposed African bat PyV species employing the recently recommended criteria provided by the Polyomaviridae Study Group of the International Committee on Taxonomy of Viruses. A comprehensive phylogenetic and recombination analysis was performed to determine genetic relationships and the distribution of recombination events in PyV from mammalian and avian species...
April 22, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28429637/analysis-of-rotation-angles-and-motions-of-the-flexible-mechanisms-in-bifurcated-blood-vessels
#15
Bin He, Shoulin Xu, An Ding, Yanmin Zhou
This article investigates the relationship of rotation angle of two ends of elastic guidewires, and motion method of guidewires and catheters in bifurcated blood vessels. The relationship of rotation angles of the two ends of the guidewire has first been studied by mathematical reasoning, indicating that the rotation angle of the front end of guidewire can be precisely described by that of the rear end. In order to satisfy the requirements of different vascular interventional surgeries, we further investigated a general model of bifurcated human blood vessels...
April 1, 2017: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/28429287/protective-effect-of-selenoprotein-x-against-oxidative-stress-induced-cell-apoptosis-in-human-hepatocyte-lo2-cells-via-the-p38-pathway
#16
Jia-Yong Tang, Ai-Hua He, Gang Jia, Guang-Mang Liu, Xiao-Ling Chen, Jing-Yi Cai, Hai-Ying Shang, Jin-Qiu Liao, Hua Zhao
Oxidative stress, as mediated by ROS (reactive oxygen species), is a significant factor in initiating the cells damaged by affecting cellular macromolecules and impairing their biological functions; SelX, a selenoprotein also known as MsrB1 belonging to the methionine sulfoxide reductase (Msr) family, is the redox repairing enzyme and involved in redox-related functions. In order to more precisely analyze the relationship between oxidative stress, cell oxidative damage, and SelX, we stably overexpressed porcine Selx full-length cDNA in human normal hepatocyte (LO2) cells...
April 20, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28428845/global-pattern-of-plant-utilization-across-different-organisms-does-plant-apparency-or-plant-phylogeny-matter
#17
Xiaohua Dai, Wei Zhang, Jiasheng Xu, Kevin J Duffy, Qingyun Guo
The present study is the first to consider human and nonhuman consumers together to reveal several general patterns of plant utilization. We provide evidence that at a global scale, plant apparency and phylogenetic isolation can be important predictors of plant utilization and consumer diversity. Using the number of species or genera or the distribution area of each plant family as the island "area" and the minimum phylogenetic distance to common plant families as the island "distance", we fitted presence-area relationships and presence-distance relationships with a binomial GLM (generalized linear model) with a logit link...
April 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28428793/transcriptomics-targeted-metabolomics-and-gene-expression-of-blackberry-leaves-and-fruits-indicate-flavonoid-metabolic-flux-from-leaf-to-red-fruit
#18
Enrique Gutierrez, Ana García-Villaraco, José A Lucas, Ana Gradillas, F Javier Gutierrez-Mañero, Beatriz Ramos-Solano
Blackberries (Rubus spp.) are among the high added value food products relevant for human health due to the increasing evidence of the beneficial effects of polyphenols, which are very abundant in these fruits. Interestingly, these compounds also play a role on plant physiology, being especially relevant their role in plant defense against biotic and abiotic stress. Hence, we hypothesize that since blackberry fruits have high amounts of flavonols and anthocyanins, leaves would also have high amounts of these compounds, and can be studied as a source of active molecules; furthermore, leaf synthesis would support their high contents in fruits...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28428612/granzyme-k-deficient-mice-show-no-evidence-of-impaired-anti-viral-immunity
#19
Lars T Joeckel, Cody C Allison, Mark Pellegrini, Catherina H Bird, Phillip Ian Bird
The biological role of granzyme K, a serine protease of cytotoxic T lymphocytes (CTL), is controversial. It has been reported to induce perforin-mediated cell death in vitro, but is also reported to be non-cytotoxic and to operate in inflammatory processes. To elucidate the biological role of this protease we have deleted the granzyme K gene in mice (mutant allele: Gzmk(tm1.1Pib); MGI:5636646). Gzmk(-/-) mice are healthy, anatomically normal, fecund, and show normal hematopoietic development. Gzmk(-/-) mice readily recover from Lymphocytic choriomeningitis virus and mouse pox Ectromelia virus infection...
April 21, 2017: Immunology and Cell Biology
https://www.readbyqxmd.com/read/28428393/biodiversity-losses-and-conservation-responses-in-the-anthropocene
#20
REVIEW
Christopher N Johnson, Andrew Balmford, Barry W Brook, Jessie C Buettel, Mauro Galetti, Lei Guangchun, Janet M Wilmshurst
Biodiversity is essential to human well-being, but people have been reducing biodiversity throughout human history. Loss of species and degradation of ecosystems are likely to further accelerate in the coming years. Our understanding of this crisis is now clear, and world leaders have pledged to avert it. Nonetheless, global goals to reduce the rate of biodiversity loss have mostly not been achieved. However, many examples of conservation success show that losses can be halted and even reversed. Building on these lessons to turn the tide of biodiversity loss will require bold and innovative action to transform historical relationships between human populations and nature...
April 21, 2017: Science
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