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https://www.readbyqxmd.com/read/29148115/the-actionability-of-exome-sequencing-testing-results
#1
Tanya Stivers, Stefan Timmermans
Genomic tests such as exome sequencing have recently become an option for diagnosing patients. The tests allow clinical geneticists to sequence the majority of patients' disease causing genetic variants. As a new technology, exome sequencing confronts the question of what the benefit is of this increased genetic information. Against a narrow perspective of clinical utility that emphasises tangible improvements in a patient's disease management, professional organisations have argued that genomic sequencing should be considered beneficial if it helps families and society...
November 2017: Sociology of Health & Illness
https://www.readbyqxmd.com/read/29144147/pursued-for-their-prescription-exposure-to-compliance-gaining-strategies-predicts-stimulant-diversion-in-emerging-adults
#2
Laura J Holt, Paige N Marut, Ty S Schepis
Researchers have begun to identify predictors of who will divert their stimulant prescriptions, as most emerging adults (EAs) who use prescription stimulants nonmedically procure these drugs from a friend or acquaintance with a prescription. Far less research has examined how EAs with attention-deficit/hyperactivity disorder (ADHD) are approached for these medications, and their affective and behavioral responses to these requests. We hypothesized that EAs with a stimulant prescription who reported greater exposure to compliance-gaining attempts from peers, particularly rational appeals for academic work, would be more likely to divert, as would EAs who reported lower resistance to peer influence...
November 16, 2017: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
https://www.readbyqxmd.com/read/29140225/key-patterns-and-predictors-of-response-to-treatment-for-military-veterans-with-post-traumatic-stress-disorder-a-growth-mixture-modelling-approach
#3
A J Phelps, Z Steel, O Metcalf, N Alkemade, K Kerr, M O'Donnell, J Nursey, J Cooper, A Howard, R Armstrong, D Forbes
BACKGROUND: To determine the patterns and predictors of treatment response trajectories for veterans with post-traumatic stress disorder (PTSD). METHODS: Conditional latent growth mixture modelling was used to identify classes and predictors of class membership. In total, 2686 veterans treated for PTSD between 2002 and 2015 across 14 hospitals in Australia completed the PTSD Checklist at intake, discharge, and 3 and 9 months follow-up. Predictor variables included co-morbid mental health problems, relationship functioning, employment and compensation status...
November 15, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/29139333/the-endurance-of-interpersonal-confrontations-as-a-prejudice-reduction-strategy
#4
Kimberly E Chaney, Diana T Sanchez
Previous work has found that individuals who have been confronted for discrimination demonstrate a reduction in explicit prejudice and use fewer stereotypes immediately after the confrontation. Although confronting prejudice has been touted as a tool for prejudice reduction, it is not known how these effects translate over time and what processes might account for their endurance. Across two studies, the present research finds that individuals used significantly fewer negative stereotypes 7 days after confrontation (Study 1) and engaged in behavioral inhibition to stereotypical cues on a probe task 1 week after confrontation...
November 1, 2017: Personality & Social Psychology Bulletin
https://www.readbyqxmd.com/read/29132364/-i-m-not-strong-enough-i-m-not-good-enough-i-can-t-do-this-i-m-failing-a-qualitative-study-of-low-socioeconomic-status-smokers-experiences-with-accesssing-cessation-support-and-the-role-for-alternative-technology-based-support
#5
Veronica C Boland, Richard P Mattick, Hayden McRobbie, Mohammad Siahpush, Ryan J Courtney
BACKGROUND: The social gradient in smoking rates persist with an overrepresentation of smoking and its associated harms concentrated within lower socioeconomic status (SES) populations. Low-SES smokers are motivated to quit but face multiple barriers when engaging a quit attempt. An understanding of the current treatment service model from the perspectives of treatment-seeking low-SES smokers is needed to inform the design of alternative smoking cessation support services tailored to the needs of low-SES populations...
November 13, 2017: International Journal for Equity in Health
https://www.readbyqxmd.com/read/29132340/what-do-japanese-residents-learn-from-treating-dying-patients-the-implications-for-training-in-end-of-life-care
#6
Kazuko Arai, Takuya Saiki, Rintaro Imafuku, Chihiro Kawakami, Kazuhiko Fujisaki, Yasuyuki Suzuki
BACKGROUND: How medical residents' experiences with care for dying patients affect their emotional well-being, their learning outcomes, and the formation of their professional identities is not fully understood. We examine residents' emotional states and learning occurring during the provision of care to dying patients and specifically discuss the impact of providing end-of-life (EOL) care on professional identity formation. METHODS: Semi-structured interviews were conducted with 13 residents who had graduated in the last 3 to 5 years...
November 13, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/29132287/a-qualitative-analysis-of-the-barriers-to-antiretroviral-therapy-initiation-among-children-2-to-18-months-of-age-in-swaziland
#7
Charisse V Ahmed, Pauline Jolly, Luz Padilla, Musa Malinga, Chantal Harris, Nobuhle Mthethwa, Inessa Ba, Amy Styles, Sarah Perry, Raina Brooks, Florence Naluyinda-Kitabire, Makhosini Mamba, Peter Preko
HIV/AIDS remains one of the leading causes of death among children under 5 years old in Swaziland. Although studies have shown that early initiation of infants and children diagnosed with HIV on antiretroviral therapy (ART) significantly reduces mortality, many children do not initiate ART until the later stages of disease. This study was designed to collect qualitative data from mothers and caregivers of HIV-positive children to identify the barriers to ART initiation. Focus group discussion (FGD) sessions were conducted in siSwati between July and September 2014 among caregivers of aged children 2-18 months in Swaziland who did or did not initiate ART between January 2011 and December 2012 after HIV DNA PCR-positive diagnosis of the infants...
December 2017: African Journal of AIDS Research: AJAR
https://www.readbyqxmd.com/read/29125957/a-network-perspective-on-comorbid-depression-in-adolescents-with-obsessive-compulsive-disorder
#8
Payton J Jones, Patrick Mair, Bradley C Riemann, Beth L Mugno, Richard J McNally
People with obsessive-compulsive disorder [OCD] frequently suffer from depression, a comorbidity associated with greater symptom severity and suicide risk. We examined the associations between OCD and depression symptoms in 87 adolescents with primary OCD. We computed an association network, a graphical LASSO, and a directed acyclic graph (DAG) to model symptom interactions. Models showed OCD and depression as separate syndromes linked by bridge symptoms. Bridges between the two disorders emerged between obsessional problems in the OCD syndrome, and guilt, concentration problems, and sadness in the depression syndrome...
November 2, 2017: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/29119657/reduced-neural-responses-to-vocal-fear-a-potential-biomarker-for-callous-uncaring-traits-in-early-childhood
#9
Caroline P Hoyniak, John E Bates, Isaac T Petersen, Chung-Lin Yang, Isabelle Darcy, Nathalie M G Fontaine
OBJECTIVE: Callous-unemotional (CU) traits are characterized by a lack of guilt and empathy, and low responsiveness to distress and fear in others. Children with CU traits are at-risk for engaging in early and persistent conduct problems. Individuals showing CU traits have been shown to have reduced neural responses to others' distress (e.g., fear). However, the neural components of distress responses in children with CU traits have not been investigated in early childhood. In the current study, we examined neural responses that underlie the processing of emotionally valenced vocal stimuli using the event-related potential technique in a group of preschoolers...
November 8, 2017: Developmental Science
https://www.readbyqxmd.com/read/29117847/the-impact-of-school-visits-on-siblings-of-children-with-cancer
#10
Isabelle Sjoberg, Jason D Pole, Marilyn Cassidy, Claudette Boilard, Sharon Costantini, Donna L Johnston
BACKGROUND: Childhood cancer affects the entire family. Siblings experience similar stress to that of the ill child, including anger, depression, jealousy, guilt, and social isolation. School reentry programs are shown to be positive interventions for patients, it is hypothesized that similar outcomes exist for siblings. OBJECTIVE: To examine the feasibility of studying the impact of the Ontario Oncology Nurse School Visitation Program on the well-being and school adjustment of siblings of pediatric cancer patients...
November 1, 2017: Journal of Pediatric Oncology Nursing: Official Journal of the Association of Pediatric Oncology Nurses
https://www.readbyqxmd.com/read/29116983/-rising-to-the-level-of-your-incompetence-exploring-what-physicians-self-assessment-of-their-performance-reveals-about-the-impact-of-the-imposter-syndrome-in-medicine
#11
Kori A LaDonna, Shiphra Ginsburg, Christopher Watling
PURPOSE: Mistakes are ubiquitous in medicine; when confronted by error, physicians may experience anxiety, guilt, and self-doubt. Feedback may be useful for navigating these feelings, but only if it matches a physician's self-assessment; self-doubt and the imposter syndrome are examples of inaccurate self-assessments that may affect receptivity to feedback. The impact of real or imagined underperformance on seemingly competent physicians is poorly understood. This study aimed to develop a deeper understanding in order to identify strategies to support all physicians who struggle...
November 7, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29112288/a-preliminary-study-of-momentary-naturalistic-indicators-of-binge-eating-episodes-in-adults-with-obesity
#12
Andrea B Goldschmidt, Ross D Crosby, Li Cao, Stephen A Wonderlich, James E Mitchell, Scott G Engel, Carol B Peterson
OBJECTIVES: Binge eating is common in adults with obesity. The Diagnostic and Statistical Manual for Psychiatric Disorders describes five indicators of binge eating (eating more rapidly than usual; eating until uncomfortably full; eating large amounts of food when not physically hungry; eating alone because of embarrassment over how much one is eating; and feeling disgusted with oneself, depressed, or very guilty after overeating), but their validity is unclear. METHOD: We examined preliminary associations between the five indicators and binge versus nonbinge episodes among 50 adults with obesity via ecological momentary assessment...
November 7, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/29111866/moral-identity-predicts-doping-likelihood-via-moral-disengagement-and-anticipated-guilt
#13
Maria Kavussanu, Christopher Ring
In this study, we integrated elements of social cognitive theory of moral thought and action and the social cognitive model of moral identity to better understand doping likelihood in athletes. Participants (N = 398) recruited from a variety of team sports completed measures of moral identity, moral disengagement, anticipated guilt, and doping likelihood. Moral identity predicted doping likelihood indirectly via moral disengagement and anticipated guilt. Anticipated guilt about potential doping mediated the relationship between moral disengagement and doping likelihood...
August 1, 2017: Journal of Sport & Exercise Psychology
https://www.readbyqxmd.com/read/29111774/an-introduction-to-network-psychometrics-relating-ising-network-models-to-item-response-theory-models
#14
M Marsman, D Borsboom, J Kruis, S Epskamp, R van Bork, L J Waldorp, H L J van der Maas, G Maris
In recent years, network models have been proposed as an alternative representation of psychometric constructs such as depression. In such models, the covariance between observables (e.g., symptoms like depressed mood, feelings of worthlessness, and guilt) is explained in terms of a pattern of causal interactions between these observables, which contrasts with classical interpretations in which the observables are conceptualized as the effects of a reflective latent variable. However, few investigations have been directed at the question how these different models relate to each other...
November 7, 2017: Multivariate Behavioral Research
https://www.readbyqxmd.com/read/29111153/guilty-pleasures-the-effect-of-perceived-overeating-on-food-addiction-attributions-and-snack-choice
#15
Helen K Ruddock, Charlotte A Hardman
Despite being widely debated throughout the scientific community, the concept of food addiction remains a popular explanation for overeating and obesity amongst the lay public. Overeating is often accompanied by feelings of guilt and dietary concern, and this may lead people to attribute their eating to an addiction in order to minimise personal responsibility. Research also indicates that food addiction attributions and dietary concern may lead people to limit their exposure to tempting foods. To test these ideas, we examined the effect of perceived overeating on food addiction attributions and snack choice...
October 28, 2017: Appetite
https://www.readbyqxmd.com/read/29110520/parental-concerns-and-attributions-of-food-pickiness-and-its-consequences-for-the-parent-child-relationship-a-qualitative-analysis
#16
Bérengère Rubio, Natalie Rigal
A qualitative study was conducted to identify how parents describe and attribute their toddler's food pickiness, a common pediatric problem during childhood. Parental strategies to respond to picky behaviors were also explored in this study. Focus groups were used with 38 parents of children aged 18-38 months. Results highlighted several consequences of child pickiness such as parental concerns about child's growth and health, conflicts at mealtime, and feelings of guilt. Parents attributed food pickiness mainly as a manifestation of opposition and assertiveness by their child...
January 1, 2017: Journal of Child Health Care: for Professionals Working with Children in the Hospital and Community
https://www.readbyqxmd.com/read/29110168/caregiver-quality-of-life-with-tyrosinemia-type-1
#17
Hailey Campbell, Rani H Singh, Eric Hall, Nadia Ali
Tyrosinemia type I (HT1) is an inborn error of metabolism (IEM). Current management guidelines include lifelong specialized diet and use of the orphan drug, nitisinone. This study explores the quality of life (QOL) of caregivers of children with HT1. Caregivers for 26 children with HT1 completed a questionnaire (TYR-QOL) adapted to this patient population from an existing validated QOL questionnaire (PKU-QOL). Responses were analyzed via domain scores, based on predetermined scoring guidelines. Results suggest HT1 has a moderate overall impact on caregiver QOL, with emotional aspects of the disease having the greatest impact...
November 6, 2017: Journal of Genetic Counseling
https://www.readbyqxmd.com/read/29099108/una-aproximaci%C3%A3-n-a-la-fenomenolog%C3%A3-a-de-la-enfermedad
#18
Carlos Alva Espinosa
Modern medicine has undergone technological progress, undoubtedly with better results, but the doctor-patient relationship has been undermined in its most important aspect, human contact. The patient experiences and confronts in solitude his adverse experience. This experience is complex, not only are the symptoms of the disease, they also include disability, isolation, fear, dependence and sometimes guilt. Phenomenology attaches a paramount importance to the data in the consciousness of the patient, as facts given with absolute value...
2017: Gaceta Médica de México
https://www.readbyqxmd.com/read/29098071/the-use-of-the-clinical-ethnographic-narrative-interview-to-understand-and-support-help-seeking-after-gender-based-violence
#19
Denise M Saint Arnault
Gender-based violence (GBV), characterized by the abduction or rape of women and girls to humiliate, intimidate, and traumatize them and their communities, is a profoundly disturbing tactic in international conflict. Long after armed conflict has ended, survivors continue to experience physical injuries, psychological trauma, and social and cultural stigma. Guilt, shame, and continued interpersonal violence can become a normalized part of daily life, significantly challenging the road to healing and recovery...
September 2017: TPM. Testing, Psychometrics, Methodology in Applied Psychology
https://www.readbyqxmd.com/read/29096278/women-s-experiences-of-pregnancy-related-pelvic-girdle-pain-a-systematic-review
#20
REVIEW
Jo Mackenzie, Esther Murray, Joanne Lusher
OBJECTIVE: to systematically review the available studies which relay the experience of pregnancy related pelvic girdle pain and how this affects women psychologically and emotionally. METHOD: a systematic review and meta-synthesis of the experiences of pregnancy related pelvic girdle pain was conducted for qualitative studies dated between 2005 and 2016. Predefined terms were used to search nine central databases and hand searches of two reference lists of identified studies were carried out...
October 16, 2017: Midwifery
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