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T1 colon cancer metastasis

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https://www.readbyqxmd.com/read/29134398/micrornas-and-their-role-for-t-stage-determination-and-lymph-node-metastasis-in-early-colon-carcinoma
#1
Melanie Rammer, Gerald Webersinke, Sophie Haitchi-Petnehazy, Eva Maier, Hubert Hackl, Pornpimol Charoentong, Theodora Malli, Maria Steinmair, Andreas L Petzer, Holger Rumpold
Worldwide, colon cancer is among the most common cancer entities. Understanding the molecular background is the key to enable accurate stage determination, which is crucial to assess optimal therapy options. The search for preoperative biomarkers is ongoing. In recent years, several studies have proposed a diagnostic and prognostic role for miRNAs in cancer. Aim of this study was to evaluate miRNA expression patterns correlating with tumor stage, especially lymph node metastasis, in primary colon carcinoma tissue...
November 13, 2017: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/28836166/laparoscopic-complete-mesocolic-excision-via-mesofascial-separation-for-left-sided-colon-cancer
#2
Shinichiro Mori, Yoshiaki Kita, Kenji Baba, Masayuki Yanagi, Kan Tanabe, Yasuto Uchikado, Hiroshi Kurahara, Takaaki Arigami, Yoshikazu Uenosono, Yuko Mataki, Akihiro Nakajo, Kosei Maemura, Shoji Natsugoe
PURPOSE: To evaluate the safety and feasibility of laparoscopic complete mesocolic excision (CME) via mesofascial separation for left-sided colon cancer. METHODS: We evaluated prospectively collected data on 65 consecutive patients with stage I-III left-sided colon cancer, who underwent laparoscopic CME between October 2011 and September 2016. After the exclusion of 5 patients who had T4b or other active tumors, 60 patients were the subjects of this analysis. The completeness of CME, preservation of the hypogastric nerve, operative data, pathological findings, complications, and length of hospital stay were assessed...
August 23, 2017: Surgery Today
https://www.readbyqxmd.com/read/28643309/-comparison-of-clinicopathological-features-and-prognosis-between-left-sided-colon-cancer-and-right-sided-colon-cancer
#3
Xianhua Gao, Guanyu Yu, Peng Liu, Liqiang Hao, Lianjie Liu, Wei Zhang
OBJECTIVE: To compare the clinicopathological features and prognosis between left-sided colon cancer (LC) and right-sided colon cancer (RC). METHODS: Clinicopathological and follow-up data of 2 174 colon carcinoma cases undergoing resection at Shanghai Changhai Hospital of The Second Military Medical University from January 2000 to December 2010 were retrospectively analyzed. Patients with transverse colon cancer, overlapping position, unknown location, recurrent cancer, multiple primary cancer, concomitant malignant tumors, preoperative chemotherapy, local resection, incomplete clinical data and missed follow up were excluded...
June 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28194526/long-term-outcomes-after-treatment-for-t1-colorectal-carcinoma-a-multicenter-retrospective-cohort-study-of-hiroshima-gi-endoscopy-research-group
#4
Yuzuru Tamaru, Shiro Oka, Shinji Tanaka, Shinji Nagata, Yuko Hiraga, Toshio Kuwai, Akira Furudoi, Tadamasa Tamura, Masaki Kunihiro, Hideharu Okanobu, Koichi Nakadoi, Hiroyuki Kanao, Makoto Higashiyama, Koji Arihiro, Kazuya Kuraoka, Fumio Shimamoto, Kazuaki Chayama
BACKGROUND: We aimed to clarify the long-term outcomes of patients with T1 colorectal carcinoma (CRC) after endoscopic resection (ER) and surgical resection. METHODS: We examined T1 CRC patients treated during 1992-2008 and who had ≥5 years of follow-up. Patients who did not meet the curative criteria after ER according to the Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines were defined as "non-endoscopically curable" and classified into three groups: ER alone (Group A: 121 patients), additional surgery after ER (Group B: 238 patients), and surgical resection alone (Group C: 342 patients)...
November 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/27601171/small-colorectal-cancers-resembling-submucosal-tumor-with-massive-submucosal-invasion-and-lymph-node-metastasis-a-report-of-two-cases-and-review-of-the-literature
#5
Takahide Shinagawa, Soichiro Ishihara, Hiroaki Nozawa, Koji Murono, Takeshi Nishikawa, Kensuke Otani, Kazuhito Sasaki, Koji Yasuda, Toshiaki Tanaka, Tomomichi Kiyomatsu, Keisuke Hata, Kazushige Kawai, Hironori Yamaguchi, Akimasa Hayashi, Mariko Tanaka, Tetsuo Ushiku, Masashi Fukayama, Toshiaki Watanabe
Colorectal cancer resembling submucosal tumor (SMT) is very rare. We herein report two cases of small colon carcinoma resembling SMT (80-year-old female and 67-year-old male), which massively invaded into the submucosal layer and accompanied marked lymphatic invasion and lymph node metastasis. We also reviewed the reported cases of colorectal carcinoma resembling SMT (SMT-like group, n=70) and analyzed the clinicopathological characteristics of this group compared with typical colorectal carcinoma cases operated at our institution (control group, n=1723)...
September 2, 2016: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/27353100/-clinical-analysis-on-lymph-node-metastasis-pattern-in-left-sided-colon-cancers
#6
Donghan Cai, Guoxian Guan, Xing Liu, Weizhong Jiang, Zhifen Chen
OBJECTIVE: To investigate the pattern of lymph node metastasis in patients with left-sided colon cancer in order to provide evidences for the choice of operation mode and the range of lymph node clearance. METHODS: Clinical data of 556 cases with left-sided colon carcinoma undergoing surgical treatment in Department of Colorectal Surgery, Fujian Medical University Union Hospital from January 2000 to October 2014 were retrospectively analyzed. Among these patients, cancer of splenic flexure and transverse colon close to splenic flexure (splenic flexure group) was found in 41 cases, descending colon cancer in 73 cases(descending colon goup) and sigmoid colon cancer in 442 cases (sigmoid colon group), respectively; T1 was found in 29 cases, T2 in 63 cases, T3 in 273 cases, T4 in 191 cases...
June 2016: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/27270724/impact-of-tumor-location-on-lymph-node-metastasis-in-t1-colorectal-cancer
#7
Erman Aytac, Emre Gorgun, Meagan M Costedio, Luca Stocchi, Feza H Remzi, Hermann Kessler
PURPOSE: Data evaluating the risk of lymph node metastasis depending upon the location of the primary tumor are limited in patients with T1 colorectal cancer. We aimed to evaluate the impact of tumor location on lymph node metastasis in T1 colorectal cancer. METHODS: Patients who underwent an oncologic resection with curative intent for T1 adenocarcinoma of the colon and rectum between January 1997 and October 2014 were assessed. Exclusion criteria were distant organ metastases, previous or concurrent cancer, past history of surgical or medical cancer treatment, preoperative chemoradiation, and patients with inflammatory bowel disease or polyposis syndromes...
August 2016: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/26689400/long-term-outcomes-after-treatment-for-t1-colorectal-carcinoma
#8
Naoki Asayama, Shiro Oka, Shinji Tanaka, Yuki Ninomiya, Yuzuru Tamaru, Kenjiro Shigita, Nana Hayashi, Hiroyuki Egi, Takao Hinoi, Hideki Ohdan, Koji Arihiro, Kazuaki Chayama
PURPOSE: Long-term outcomes of patients with T1 colorectal carcinoma (CRC) treated by endoscopic resection (ER) or surgical resection are unclear in relation to the curative criteria in the Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines. The aim of this study was to retrospectively compare the long-term outcomes among patients with T1 CRC in relation to the treatment methods. METHODS: We examined 322 T1 CRC cases treated between January 1992 and August 2008 at Hiroshima University Hospital...
March 2016: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/26573300/long-term-outcomes-after-treatment-for-pedunculated-type-t1-colorectal-carcinoma-a-multicenter-retrospective-cohort-study
#9
MULTICENTER STUDY
Naoki Asayama, Shiro Oka, Shinji Tanaka, Shinji Nagata, Akira Furudoi, Toshio Kuwai, Seiji Onogawa, Tadamasa Tamura, Hiroyuki Kanao, Yuko Hiraga, Hideharu Okanobu, Takayasu Kuwabara, Masaki Kunihiro, Shinichi Mukai, Eizo Goto, Fumio Shimamoto, Kazuaki Chayama
BACKGROUND: The risk for lymph node metastasis and the prognostic significance of pedunculated-type T1 colorectal carcinomas (CRCs) require further study. We aimed to assess the validity of the 2014 Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines based on long-term outcomes of pedunculated-type T1 CRCs. METHODS: In this multicenter retrospective cohort study, we examined 176 patients who underwent resection endoscopically or surgically at 14 institutions between January 1990 and December 2010...
July 2016: Journal of Gastroenterology
https://www.readbyqxmd.com/read/26448934/circulating-galectin-1-and-90k-mac-2bp-correlated-with-the-tumor-stages-of-patients-with-colorectal-cancer
#10
Keng-Liang Wu, Hong-Hwa Chen, Chen-Tzi Pen, Wen-Ling Yeh, Eng-Yen Huang, Chang-Chun Hsiao, Kuender D Yang
BACKGROUND: The simultaneous correlation of serum galectin-1, galectin-3, and 90K/Mac-2BP levels with clinical stages of patients with colorectal cancer has not yet been clarified. We plan to measure the serum levels of galectin-1, galectin-3, and 90K/Mac-2BP of patients at different stages of colorectal cancer and analyze the correlation of these galectins with stages of colorectal cancers. METHODS: 198 colorectal cancer patients (62 ± 13 (range 31-85) years old, 43...
2015: BioMed Research International
https://www.readbyqxmd.com/read/26403233/practice-parameters-for-early-colon-cancer-management-italian-society-of-colorectal-surgery-societ%C3%A3-italiana-di-chirurgia-colo-rettale-siccr-guidelines
#11
F Bianco, A Arezzo, F Agresta, C Coco, R Faletti, Z Krivocapic, G Rotondano, G A Santoro, N Vettoretto, S De Franciscis, A Belli, G M Romano
Early colon cancer (ECC) has been defined as a carcinoma with invasion limited to the submucosa regardless of lymph node status and according to the Royal College of Pathologists as TNM stage T1 NX M0. As the potential risk of lymph node metastasis ranges from 6 to 17% and the preoperative assessment of lymph node metastasis is not reliable, the management of ECC is still controversial, varying from endoscopic to radical resection. A meeting on recent advances on the management of colorectal polyps endorsed by the Italian Society of Colorectal Surgery (SICCR) took place in April 2014, in Genoa (Italy)...
October 2015: Techniques in Coloproctology
https://www.readbyqxmd.com/read/26345965/influence-of-the-dcc-gene-on-proliferation-and-carcinoembryonic-antigen-expression-in-the-human-colorectal-cancer-cell-line-sw1116
#12
H W Jiang, J Wang, H J Li, J K Peng, X P Gao, F Chen
This study investigated the effects of stable transfection of the exogenous wild-type DCC gene on growth of the human colorectal carcinoma cell line SW1116 in vitro. The DCC gene was amplified from normal human colon tissue by reverse transcription-polymerase chain reaction and used to construct a recombinant expression plasmid, pcDNA3.1(+)-DCC. DCC-negative SW1116 cells were transfected with pcDNA3.1(+)-DCC. Cell viability was tested by the methyl thiazolyl tetrazolium (MTT) assay. Immunofluorescence staining was used to determine the effects of pcDNA3...
2015: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/25331008/radical-surgery-with-total-mesorectal-excision-in-patients-with-t1-rectal-cancer
#13
Yakup Kulu, Beat P Müller-Stich, Thomas Bruckner, Tobias Gehrig, Markus W Büchler, Frank Bergmann, Alexis Ulrich
BACKGROUND: Radical resection with total mesorectal excision (TME) is the accepted standard of care for most rectal cancers. However, T1 rectal cancers may be at low risk for metastases and are therefore treatable with local resection. The aim of our study was to investigate whether the identification of these patients is possible through existing selection criteria. METHODS: Between 2001 and 2012, radical resection with TME was performed in 68 patients with a histologically confirmed T1 adenocarcinoma of the rectum...
2015: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/25145501/survival-paradox-between-stage-iib-c-t4n0-and-stage-iiia-t1-2n1-colon-cancer
#14
MULTICENTER STUDY
Min Jung Kim, Seung-Yong Jeong, Sang-Ji Choi, Seung-Bum Ryoo, Ji Won Park, Kyu Joo Park, Jae Hwan Oh, Sung-Bum Kang, Hyoung-Chul Park, Seung Chul Heo, Jae-Gahb Park
BACKGROUND: The survival paradox between stage IIB/C (T4N0) and stage IIIA (T1-2N1) colon cancer remains in the 7th edition of the American Joint Committee on Cancer staging system. This multicenter study aimed to compare the oncologic outcomes of T4N0 and T1-2N1 colon cancers and to investigate the presumptive prognostic factors that might influence the survival paradox. METHODS: Patients who underwent curative surgery for pT4N0 (n = 224) and pT1-2N1 (n = 135) primary colon cancer between January 1999 and December 2010 at five tertiary referral cancer centers were included for analysis...
February 2015: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/25040998/recurrence-risk-and-prognostic-parameters-in-stage-i-rectal-cancers
#15
MULTICENTER STUDY
Sener Cihan, Mehmet Kucukoner, Nuriye Ozdemir, Faysal Dane, Mehmet Ali Nahit Sendur, Dogan Yazilitas, Zuhat Urakci, Ayse Durnali, Sinemis Yuksel, Sercan Aksoy, Dilsen Colak, Mehmet Metin Seker, Burcu Yapar Taskoylu, Arzu Oguz, Abdurrahman Isikdogan, Nurullah Zengin
BACKGROUND: The standard therapy for stage I rectum cancer is surgical resection. Currently, there is no strong evidence to suggest that any type of adjuvant therapy is beneficial. The risks of local relapse and distant metastasis are higher in rectal tumors. Therefore, while there is no clearly defined absolute indication for adjuvant therapy in lymph node negative colon cancers, rectum tumors that are T3N0 and higher require adjuvant treatment. Due to the more aggressive nature of rectal cancers, we explored the clinical and pathologic factors that could predict the risk of relapse in Stage I (T1-T2) disease and whether there was any progression-free survival benefit to adjuvant therapy...
2014: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/25040773/towards-safer-and-appropriate-application-of-endoscopic-submucosal-dissection-for-t1-colorectal-carcinoma-as-total-excisional-biopsy-future-perspectives
#16
REVIEW
Shinji Tanaka, Naoki Asayama, Kenjiro Shigita, Nana Hayashi, Shiro Oka, Kazuaki Chayama
According to the Japanese Society for Cancer of the Colon and Rectum Guidelines 2014 for the Treatment of Colorectal Cancer, cases with T1 colorectal carcinoma should be considered for additional colectomy with lymph node dissection when histologically complete en bloc resection is endoscopically carried out and when one of the four risk factors listed below is present. These four risk factors are: (i) submucosal (SM) invasion depth ≥1000 μm; (ii) positive vascular invasion; (iii) poorly differentiated adenocarcinoma, signet ring cell carcinoma, or mucinous carcinoma; and (iv) grade 2/3 budding at the deepest part of SM invasion...
January 2015: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/24986011/laparoscopic-complete-mesocolic-excision-with-radical-lymph-node-dissection-along-the-surgical-trunk-for-right-colon-cancer
#17
Shinichiro Mori, Kenji Baba, Masayuki Yanagi, Yoshiaki Kita, Shigehiro Yanagita, Yasuto Uchikado, Takaaki Arigami, Yoshikazu Uenosono, Hiroshi Okumura, Akihiro Nakajo, Kosei Maemuras, Sumiya Ishigami, Shoji Natsugoe
BACKGROUND: We have evaluated the safety and feasibility of combining median-to-lateral and anterior-to-median (MLAM) approaches to perform laparoscopic complete mesocolic excision (CME) with radical lymph node dissection along the gastrocolic trunk of Henle (GTH) for right hemicolon cancer. PATIENTS AND METHODS: We retrospectively analyzed data obtained from a prospectively maintained database on 31 consecutive patients who had undergone laparoscopic CME with radical lymph node dissection for right hemicolon cancer between January 2010 and December 2013...
January 2015: Surgical Endoscopy
https://www.readbyqxmd.com/read/24281433/condition-of-muscularis-mucosae-is-a-risk-factor-for-lymph-node-metastasis-in-t1-colorectal-carcinoma
#18
Koichi Nakadoi, Shiro Oka, Shinji Tanaka, Nana Hayashi, Motomi Terasaki, Koji Arihiro, Fumio Shimamoto, Kazuaki Chayama
BACKGROUND: The Japanese Society for Cancer of the Colon and Rectum Guidelines for the Treatment of Colorectal Cancer 2010 state that curable T1 colorectal carcinoma (CRC) after endoscopic resection shows favorable histologic grade, absence of vessel involvement, submucosal invasion depth of <1,000 μm, and low-grade tumor budding. METHODS: We evaluated 322 consecutive T1 CRCs with LN dissection between January 1993 and March 2012. According to the muscularis mucosae condition, CRCs were classified into three groups: type A, clearly identified; type B, incompletely disrupted with deformity; or type C, completely disrupted...
April 2014: Surgical Endoscopy
https://www.readbyqxmd.com/read/24124150/macc1-is-related-to-colorectal-cancer-initiation-and-early-stage-invasive-growth
#19
Bing Ren, Vladislav Zakharov, Qi Yang, Loralee McMahon, JiangZhou Yu, Wenqing Cao
OBJECTIVES: To investigate metastasis associated in colon cancer 1 (MACC1) and MET expression in colorectal adenoma, Tis, early-stage invasive (T1 and T2), and advanced adenocarcinoma with liver metastasis using immunohistochemistry. METHODS: Ninety-three paraffin-embedded colorectal tumor specimens were immunohistochemically analyzed for MACC1 and MET protein expression. RESULTS: MACC1 expression was upregulated in the transition from adenoma to Tis; its expression was further elevated during tumor progression from Tis to early invasive carcinoma...
November 2013: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/23898232/t1-colorectal-cancer-with-synchronous-liver-metastasis
#20
Kiichi Sugimoto, Masaya Kawai, Kazuhiro Takehara, Yoshihiko Tashiro, Shinya Munakata, Shun Ishiyama, Hiromitsu Komiyama, Makoto Takahashi, Yutaka Kojima, Michitoshi Goto, Yuichi Tomiki, Kazuhiro Sakamoto, Seiji Kawasaki
The patient was a 68-year-old man who was admitted to our hospital with a liver tumor. Abdominal ultrasonography and computed tomography revealed a liver tumor 30 mm in diameter. On colonoscopy, a pedunculated tumor with a central depression (20 mm in diameter) was observed in the ascending colon, and this tumor was considered to be invading deeply into the submucosal layer. Right hemicolectomy with D3 lymphadenectomy and partial hepatectomy were performed simultaneously. On histopathological examination of the resected specimen, the tumor was a well-differentiated tubular adenocarcinoma with 3,000 μm invasion of the submucosal layer...
May 2013: Case Reports in Gastroenterology
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