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T1 colon cancer meta

Marie Louise Malmstrøm, Adrian Săftoiu, Peter Vilmann, Tobias Wirenfeldt Klausen, Ismail Gögenur
BACKGROUND AND OBJECTIVES: Treatment of colonic cancer patients is highly dependent on the depth of tumor invasion (T-stage) as well as the extension of lymph node involvement (N-stage). We aimed to systematically review the accuracy of endoscopic ultrasound (EUS) for staging of colonic cancer proximal to the rectum. PATIENTS AND METHODS: Men and women with colonic adenocarcinomas were included in the study. EUS staging was compared to histopathology as the gold standard...
September 2016: Endoscopic Ultrasound
Elias Nerad, Max J Lahaye, Monique Maas, Patty Nelemans, Frans C H Bakers, Geerard L Beets, Regina G H Beets-Tan
OBJECTIVE: The purpose of this article is to determine the accuracy of CT in the detection of tumor invasion beyond the bowel wall and nodal involvement of colon carcinomas. A literature search was performed to identify studies describing the accuracy of CT in the staging of colon carcinomas. Studies including rectal carcinomas that were inseparable from colon carcinomas were excluded. Publication bias was explored by using a Deeks funnel plot asymmetry test. A hierarchic summary ROC model was used to construct a summary ROC curve and to calculate summary estimates of sensitivity, specificity, and diagnostic odds ratios (ORs)...
November 2016: AJR. American Journal of Roentgenology
T M H Gall, S R Markar, D Jackson, A Haji, O Faiz
AIM: With an increasing array of treatment modalities available for colon cancer, it is increasingly important to stage tumours accurately to allocate the appropriate management. This study evaluated the accuracy of mini-probe endoscopic ultrasound (EUS) in assigning clinical stage to colon cancer. METHOD: An electronic search was performed in January 2013 using the Embase, MEDLINE and Cochrane databases. This was supplemented by a hand search of published abstracts from scientific meetings...
January 2014: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
Xian-peng Qin, Yong Zhou, Yi Chen, Ning-ning Li, Bo Chen, Ping Yang, Xiao-ting Wu
BACKGROUND AND OBJECTIVE: The association between glutathione S-transferase T1 (GSTT1) gene polymorphisms and colorectal cancer (CRC) susceptibility is still controversial. In order to clarify the effect of GSTT1 genotype on the CRC risk, we carried out an updated meta-analysis of published case-control studies to provide more precise evidence. METHODS: Two investigators independently searched the databases of Pubmed, EMBASE and China National Knowledge Infrastructure (CNKI) up to October 15, 2012...
December 2013: Clinics and Research in Hepatology and Gastroenterology
Martijn Hgm van der Pas, Sybren Meijer, Otto S Hoekstra, Ingid I Riphagen, Henrica C W de Vet, Dirk L Knol, Nicole C T van Grieken, Wilhelmus J H J Meijerink
BACKGROUND: No consensus exists on the validity of the sentinel-lymph-node procedure for assessment of nodal status in patients with colorectal cancer. We aimed to assess the diagnostic performance of this procedure. METHODS: We searched Embase and PubMed databases for studies published before March 20, 2010. Eligible studies had a prospective design, a sample size of at least 20 patients, and reported the rate of sentinel-lymph-node positivity. Individual patient data were requested for localisation and T-stage stratification...
June 2011: Lancet Oncology
Hongwei Wan, Yong Zhou, Ping Yang, Bo Chen, Guiqing Jia, Xiaoting Wu
BACKGROUND: Studies investigating the association between genetic polymorphism of glutathione S-transferase T1 (GSTT1) and risk of colorectal cancer have reported conflicting results. In order to clarify the effect of GSTT1 polymorphism on the risk of developing colorectal cancer, we carried out a meta-analysis using published data to obtain more precise estimates of risk. METHODS: Electronic searches of PubMed and EMBASE were conducted to select studies for this meta-analysis...
February 2010: Cancer Epidemiology
Ronan A Cahill, Joel Leroy, Jacques Marescaux
BACKGROUND: Endoscopic resectional techniques for colon cancer are undermined by their inability to determine lymph node status. This limits their application to only those lesions at the most minimal risk of lymphatic dissemination whereas their technical capacity could allow intraluminal or even transluminal address of larger lesions. Sentinel node biopsy may theoretically address this breach although the variability of its reported results for this disease is worrisome. METHODS: Medline, EMBASE and Cochrane databases were interrogated back to 1999 to identify all publications concerning lymphatic mapping for colon cancer with reference cross-checking for completeness...
2008: BMC Surgery
A Amato, M Pescatori
BACKGROUND: The improvement of renal allograft survival by pre-transplantation transfusions alerted the medical community to the potential detrimental effect of transfusions in patients being treated for cancer. OBJECTIVES: The present meta-analysis aims to evaluate the role of perioperative blood transfusions (PBT) on colorectal cancer recurrence. This is accomplished by validating the results of a previously published meta-analysis (Amato 1998); and by updating it to December 2004...
2006: Cochrane Database of Systematic Reviews
J G Hengstler, M Arand, M E Herrero, F Oesch
It has become clear that several polymorphisms of human drug-metabolizing enzymes influence an individual's susceptibility for chemical carcinogenesis. This review gives an overview on relevant polymorphisms of four families of drug-metabolizing enzymes. Rapid acetylators (with respect to N-acetyltransferase NAT2) were shown to have an increased risk of colon cancer, but a decreased risk of bladder cancer. In addition an association between a NAT1 variant allele (NAT*10, due to mutations in the polyadenylation site causing approximately two fold higher activity) and colorectal cancer among NAT2 rapid acetylators was observed, suggesting a possible interaction between NAT1 and NAT2...
1998: Recent Results in Cancer Research
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