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https://www.readbyqxmd.com/read/29349946/validation-study-of-a-korean-version-of-the-abbreviated-university-of-california-los-angeles-ptsd-reaction-index-abb-ucla-ptsd-ri-for-adolescents
#1
Tae Ho Kim, Doug Hyun Han, Seo Koo Yoo, Jung Jae Lee, Ji Eun Kim, Un Sun Chung
BACKGROUND: We aimed to verify a Korean version of the Abbreviated University of California, Los Angeles, Post-Traumatic Stress Disorder Reaction Index (Abb-UCLA-PTSD RI-Korean version) among Korean adolescents to assess post-traumatic stress in this population. METHODS: We recruited 1,254 adolescents who completed the Abb-UCLA-PTSD RI-Korean version scale, the Child Report of Post-Traumatic Symptoms (CROPS), the Lifetime Incidence of Traumatic Events (LITE), and the Children's Depression Inventory (CDI)...
January 29, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29349869/clostridium-difficile-infection-is-associated-with-graft-loss-in-solid-organ-transplant-recipients
#2
A Cusini, C Béguelin, S Stampf, K Boggian, C Garzoni, M Koller, O Manuel, P Meylan, N J Mueller, H Hirsch, M Weisser, C Berger, C van Delden
Clostridium difficile infection (CDI) is a leading cause of infectious diarrhea in solid organ transplant recipients (SOT). We aimed to assess incidence, risk factors and outcome of CDI within the Swiss Transplant Cohort Study (STCS). We performed a case-control study of SOT recipients in the STCS diagnosed with CDI between May 2008 and August 2013. We matched two control subjects per case by age at transplantation, sex and transplanted organ. A multivariable analysis was performed using conditional logistic regression to identify risk factors and evaluate outcome of CDI...
January 19, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29343033/-clinical-features-and-prognosis-of-18-cases-of-primary-lymphocytic-hypophysitis
#3
Q Wei, G Q Yang, Y J Li, L Zang, Y Pei, J Du, W J Gu, J M Ba, Z H Lü, J T Dou, Y M Mu, J M Lu
Objective: To analyze clinical features, prognosis and treatment of lymphocytic hypophysitis (LYH). Methods: The clinical data, treatments and outcomes of 18 cases diagnosed as LYH at Chinese PLA General Hospital between January 2001 and July 2017 was respectively reviewed. Results: Eighteen patients with histology-proven LYH (13 females and 5 males ) were identified. All lymphocytic adenohypophysitis (LAH) were females(n=6), two of whom were associated with pregnancy. Eleven patients (6 females and 5 males) had lymphocytic panhypophysitis (LPH) and one(female) had hypothalamitis...
January 9, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29342270/whole-genome-analysis-reveals-the-evolution-and-transmission-of-an-mdr-dh-nap11-106-clostridium-difficile-clone-in-a-paediatric-hospital
#4
Larry K Kociolek, Egon A Ozer, Dale N Gerding, David W Hecht, Sameer J Patel, Alan R Hauser
Background: Clostridium difficile strain DH/NAP11/106, a relatively antibiotic-susceptible strain, is now the most common cause of C. difficile infection (CDI) among adults in the USA. Objectives: To identify mechanisms underlying the evolution and transmission of an MDR DH/NAP11/106 clone. Methods: WGS (Illumina MiSeq), restriction endonuclease analysis (REA) and antibiotic susceptibility testing were performed on 134 C. difficile isolates collected from paediatric patients with CDI over a 2 year period...
January 12, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29336930/exploring-ways-to-improve-cdi-outcomes
#5
REVIEW
T Galpérine, B Guery
Clostridium difficile is an anaerobic spore-forming Gram-positive bacillus recognized as an evolving international health problem. Metronidazole and vancomycin were - until recently - the only drugs available to treat C. difficile infection (CDI). Better knowledge of the pathophysiology and the development of new drugs completely modified the management of initial episodes and recurrences of CDI. Fidaxomicin significantly reduced recurrences compared with vancomycin. New drugs are also currently evaluated (cadazolid, surotomycin, ridinilazole, rifaximin)...
January 11, 2018: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/29336929/economic-burden-and-cost-effective-management-of-clostridium-difficile-infections
#6
REVIEW
S M Heimann, M R Cruz Aguilar, S Mellinghof, M J G T Vehreschild
Clostridium difficile infection (CDI) is the most important cause of healthcare-associated infectious diarrhea in industrialized countries. We performed a literature review of the overall economic burden of initial and recurrent CDI as well as of the cost-effectiveness of the various treatment strategies applied in these settings. Even though analysis of health economic data is complicated by the limited comparability of results, our review identified several internationally consistent results. Authors from different countries have shown that recurrent CDI disproportionally contributes to the overall economic burden of CDI and therefore offers considerable saving potential...
January 11, 2018: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/29336928/tackling-the-recurrence-of-clostridium-difficile-infection
#7
REVIEW
N Petrosillo
The pathogenesis of recurrent Clostridium difficile infection (CDI) is still poorly understood. The risk of recurrence is approximately 20% after an initial CDI episode and dramatically increases with subsequent CDI recurrences. Several factors may play a role in recurrent CDI (rCDI), including conditions influencing germination, metabolic pathways that influence toxin production of C. difficile, and the microbiota composition offering protection against colonization and disease caused by C. difficile. Paradoxically, the currently recommended treatment for acute symptomatic CDI, i...
January 11, 2018: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/29336752/external-validation-of-velazquez-gomez-severity-score-index-and-atlas-scores-and-the-identification-of-risk-factors-associated-with-mortality-in-clostridium-difficile-infections
#8
Matthew L Figh, Evon S L Zoog, Richard A Moore, Benjamin W Dart, Gregory Heath, Reed M Butler, Cuilan Gao, Joseph C Kong, J Daniel Stanley
Treatment guidelines for Clostridium difficile infection (CDI) are limited by a lack of widely accepted clinical prediction tools (CPTs). Two published CPTs, the Velazquez-Gomez Severity Score Index (VGSSI) and ATLAS scores, were evaluated, and variables showing the greatest correlation with mortality in patients with CDI were identified to further develop an objective, mortality-based CPT. A retrospective review of the charts of 271 hospitalized patients with CDI was performed. VGSSI and ATLAS scores were assigned...
December 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/29331915/theory-of-water-treatment-by-capacitive-deionization-with-redox-active-porous-electrodes
#9
Fan He, P M Biesheuvel, Martin Z Bazant, T Alan Hatton
Capacitive deionization (CDI) for water treatment, which relies on the capture of charged species to sustain the electrical double layers (EDLs) established within porous electrodes under an applied electrical potential, can be enhanced by the chemical attachment of fixed charged groups to the porous electrode electrodes (ECDI). It has recently been demonstrated that further improvements in capacity and energy storage can be gained by functionalization of the electrode surfaces with redox polymers in which the charge on the electrodes can be modulated through Faradaic reactions under different cell voltages in a capacitive process that can be called "Faradaic CDI" (FaCDI)...
January 3, 2018: Water Research
https://www.readbyqxmd.com/read/29330131/response-of-human-induced-pluripotent-stem-cell-derived-cardiomyocytes-to-several-pharmacological-agents-when-intrinsic-syncytial-pacing-is-overcome-by-acute-external-stimulation
#10
Haoyu Zeng, Bharathi Balasubramanian, Armando Lagrutta, Frederick Sannajust
We challenged human induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) syncytia, mainly, CDI iCells with several classes of well-characterized pharmacological agents (including hERG blocker, Nav1.5 blocker, Cav1.2 blocker and opener, β-adrenergic agonist, and If blocker) under pacing conditions, utilizing the Cardio-ECR instrument, a non-invasive platform featuring simultaneous and continuous measurement of synchronized beating rate and contractility (both signals were acquired simultaneously and well aligned) ...
January 9, 2018: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/29329346/evaluation-of-bloodstream-infections-clostridium-difficile-infections-and-gut-microbiota-in-pediatric-oncology-patients
#11
Bryan T Nycz, Samuel R Dominguez, Deborah Friedman, Joanne M Hilden, Diana Ir, Charles E Robertson, Daniel N Frank
Bloodstream infections (BSI) and Clostridium difficile infections (CDI) in pediatric oncology/hematology/bone marrow transplant (BMT) populations are associated with significant morbidity and mortality. The objective of this study was to explore possible associations between altered microbiome composition and the occurrence of BSI and CDI in a cohort of pediatric oncology patients. Stool samples were collected from all patients admitted to the pediatric oncology floor from Oct.-Dec. 2012. Bacterial profiles from patient stools were determined by bacterial 16S rRNA gene profiling...
2018: PloS One
https://www.readbyqxmd.com/read/29323229/facile-synthesis-of-tio2-zro2-nanofibers-nitrogen-co-doped-activated-carbon-to-enhance-the-desalination-and-bacterial-inactivation-via-capacitive-deionization
#12
Ahmed S Yasin, Ibrahim M A Mohamed, Hamouda M Mousa, Chan Hee Park, Cheol Sang Kim
Capacitive deionization, as a second generation electrosorption technique to obtain water, is one of the most promising water desalination technologies. Yet; in order to achieve high CDI performance, a well-designed structure of the electrode materials is needed, and is in high demand. Here, a novel composite nitrogen-TiO2/ZrO2 nanofibers incorporated activated carbon (NACTZ) is synthesized for the first time with enhanced desalination efficiency as well as disinfection performance towards brackish water. Nitrogen and TiO2/ZrO2 nanofibers are used as the support of activated carbon to improve its low capacitance and hydrophobicity, which had dramatically limited its adequacy during the CDI process...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29322624/nasogastric-tube-and-outcomes-of-clostridium-difficile-infection-a-systematic-review-and-meta-analysis
#13
Karn Wijarnpreecha, Suthanya Sornprom, Charat Thongprayoon, Parkpoom Phatharacharukul, Wisit Cheungpasitporn
AIMS: Clostridium difficile infection (CDI) is a major concern for public health worldwide. Interestingly, the risk of poor clinical outcomes of CDI in patients with nasogastric tube (NGT) insertion is still controversial. The aim of this study was to assess the outcomes of CDI in patients with NGT insertion. METHODS: A literature search was performed using MEDLINE, EMBASE, and The Cochrane Database of Systematic Reviews from inception through November 2017. Studies that reported relative risks, odds ratios, or hazard ratios comparing the clinical outcome of CDI in patients with NGT versus those who did not were included...
January 11, 2018: Journal of Evidence-based Medicine
https://www.readbyqxmd.com/read/29318293/synthesis-of-novel-3d-rich-%C3%AE-amino-acid-derived-3-pyrazolidinones
#14
Jaka Glavač, Georg Dahmann, Franc Požgan, Sebastijan Ričko, Bogdan Štefane, Jurij Svete, Uroš Grošelj
Synthetic approaches towards novel 3-pyrazolidinone derivatives functionalized at positions N(1) and/or C(5) were studied. 5-Aminoalkyl-3-pyrazolidinones were prepared in four steps from N-protected glycines via Masamune-Claisen homologation, reduction, O-mesylation, and cyclisation with a hydrazine derivative. The free amines were prepared by acidolytic deprotection. Title compound was also prepared by 'ring switching' transformation of N-Boc-pyrrolin-2(5H)-one with hydrazine hydrate. Hydrogenolytic deprotection of 5-(N-alkyl-N-Cbz-aminomethyl)pyrazolidine-3-ones followed by cyclisation with 1,1'-carbonyldiimidazole (CDI) gave two novel representatives of perhydroimidazo[1,5-b] pyrazole, which is an almost unexplored heterocyclic system...
December 2017: Acta Chimica Slovenica
https://www.readbyqxmd.com/read/29317259/adherence-to-contact-precautions-among-different-types-of-healthcare-workers-through-video-monitoring-in-a-tertiary-hospital
#15
Yuichi Katanami, Kayoko Hayakawa, Takeshi Shimazaki, Yuko Sugiki, Saho Takaya, Kei Yamamoto, Satoshi Kutsuna, Yasuyuki Kato, Norio Ohmagari
BACKGROUND: Contact precautions are required to prevent transmission of multidrug-resistant organisms; however, reports on adherence rates vary. Through video monitoring, we evaluated adherence to the use of personal protective equipment (PPE) among different types of healthcare workers. METHODS: This study was an observational study conducted in a 781-bed tertiary hospital from July 2016 to March 2017. We installed cameras in areas where staff don PPE. Infection control teams observed the videos and assessed adherence rates...
January 6, 2018: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29309934/update-of-treatment-algorithms-for-clostridium-difficile-infection
#16
REVIEW
R E Ooijevaar, Y H van Beurden, E M Terveer, A Goorhuis, M P Bauer, J J Keller, C J J Mulder, E J Kuijper
BACKGROUND: Clostridium difficile is the leading cause of antibiotic-associated diarrhea, both in healthcare facilities and the community. The recurrence rate of C. difficile infection (CDI) remains high, up to 20%. Since the publication of the ESCMID guidance document on CDI treatment in 2014, new therapeutic approaches have been developed and tested to achieve higher sustained clinical cure in CDI. AIM: To review novel treatments and approaches for CDI, except probiotics and vaccines...
January 5, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29309845/non-conventional-antimicrobial-and-alternative-therapies-for-the-treatment-of-clostridium-difficile-infection
#17
REVIEW
Niloufar Roshan, Katherine A Hammer, Thomas V Riley
Clostridium difficile is an anaerobic, Gram-positive, spore-forming bacillus that causes disease ranging from self-limiting diarrhoea to severe pseudomembranous colitis. C. difficile infection (CDI) commonly affects hospitalised patients and is increasingly identified in patients in the community with no hospital contact. For the last 15 years the incidence of CDI worldwide has been rising, especially in the northern hemisphere. The yearly average number of hospitalizations as a result of this disease is estimated to be over a quarter of a million per year in the United States alone...
January 5, 2018: Anaerobe
https://www.readbyqxmd.com/read/29309446/patella-alta-a-comprehensive-review-of-current-knowledge
#18
Roland M Biedert, Philippe M Tscholl
We systematically reviewed patella alta with respect to type of measurements, reported cutoff values, cutoff values for surgical correction, and proposed surgical techniques. Using the term patella alta, we performed a systematic literature search on PubMed. Inclusion criteria were original study or review articles, publication in peer-reviewed English-language journals between 2000 and 2017, and narrative description or measurement of human patellar height on plain radiographs or magnetic resonance imaging (MRI)...
November 2017: American Journal of Orthopedics
https://www.readbyqxmd.com/read/29305541/assessing-the-burden-of-c-difficile-infection-in-low-and-middle-income-countries
#19
G A Roldan, A X Cui, N R Pollock
In contrast to the significant resources invested in diagnosis and prevention of C. difficile infection (CDI) in resource-rich settings, in resource-limited settings patients with community- and hospital-acquired diarrhea may not routinely be tested for CDI. Is CDI actually less frequent or severe in resource-limited settings, or might we be missing an important opportunity to prevent CDI-related morbidity and mortality (and to promote antibiotic stewardship) in these settings? Here, we review the literature to assess the overall burden of CDI in low- and middle-income countries...
January 5, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29305285/national-healthcare-safety-network-laboratory-identified-clostridium-difficile-event-reporting-a-need-for-diagnostic-stewardship
#20
Clare Rock, Zoi Pana, Surbhi Leekha, Polly Trexler, Jennifer Andonian, Avinash Gadala, Karen C Carroll, Lisa L Maragakis
We describe the proportion of health care facility-onset Clostridium difficile infection (HO-CDI) National Healthcare Safety Network laboratory-identified events at our facility that were deemed nontrue HO-CDIs. Reasons included testing in a patient without significant diarrhea or with recent laxative use, or delayed testing. Standardized infection ratios using only true HO-CDI in the numerator were improved compared with publically reported standardized infection ratios. A prioritization matrix identifies which clinical services could benefit most from directed diagnostic stewardship interventions...
January 2, 2018: American Journal of Infection Control
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