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https://www.readbyqxmd.com/read/29737091/-expression-of-axin-and-macc1-in-gastric-carcinoma-and-its-clinical-significance
#1
Bo Zhu, Dan-Na Wang, Xiao-Meng Gong, Lan Yu, Shi-Wu Wu, Yi-Sheng Tao
OBJECTIVE: To investigate the expression of axis inhibition protein (AXIN) and metastasis-associated in colon cancer-1 (MACC1) in gastric carcinoma and their relationship to the clinicopathologic characteristics. METHODS: Expressions of AXIN and MACC1 proteins were examined by immunohistochemistry containing 100 specimens of gastric tissues (gastric carcinoma group) and 60 specimens of normal gastric mucosa tissues (control group,the nearby tissues of the excised specimen of gastric cancer patients,from the tumor of the gastric cancer >5...
January 2018: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/29715580/expression-of-p27-and-c-myc-by-immunohistochemistry-in-breast-ductal-cancers-in-african-american-women
#2
Farhan Khan, Luisel J Ricks-Santi, Rabia Zafar, Yasmine Kanaan, Tammey Naab
OBJECTIVES: Proteins p27 and c-Myc are both key players in the cell cycle. While p27, a tumor suppressor, inhibits progression from G1 to S phase, c-Myc, a proto-oncogene, plays a key role in cell cycle regulation and apoptosis. The objective of our study was to determine the association between expression of c-Myc and the loss of p27 by immunohistochemistry (IHC) in the four major subtypes of breast cancer (BC) (Luminal A, Luminal B, HER2, and Triple Negative) and with other clinicopathological factors in a population of 202 African-American (AA) women...
April 5, 2018: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29706964/crosstalk-between-peroxisome-proliferator-activated-receptor-gamma-and-the-canonical-wnt-%C3%AE-catenin-pathway-in-chronic-inflammation-and-oxidative-stress-during-carcinogenesis
#3
REVIEW
Alexandre Vallée, Yves Lecarpentier
Inflammation and oxidative stress are common and co-substantial pathological processes accompanying, promoting, and even initiating numerous cancers. The canonical WNT/β-catenin pathway and peroxisome proliferator-activated receptor gamma (PPARγ) generally work in opposition. If one of them is upregulated, the other one is downregulated and vice versa . WNT/β-catenin signaling is upregulated in inflammatory processes and oxidative stress and in many cancers, although there are some exceptions for cancers...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29615567/the-roles-of-the-wnt-antagonists-axin-and-lrp4-during-embryogenesis-of-the-red-flour-beetle-tribolium-castaneum
#4
Romy Prühs, Anke Beermann, Reinhard Schröder
In both vertebrates and invertebrates, the Wnt-signaling pathway is essential for numerous processes in embryogenesis and during adult life. Wnt activity is fine-tuned at various levels by the interplay of a number of Wnt-agonists (Wnt ligands, Frizzled-receptors, Lrp5/6 coreceptors) and Wnt-antagonists (among them Axin, Secreted frizzled and Lrp4) to define anterior-posterior polarity of the early embryo and specify cell fate in organogenesis. So far, the functional analysis of Wnt-pathway components in insects has concentrated on the roles of Wnt-agonists and on the Wnt-antagonist Axin...
October 15, 2017: Journal of Developmental Biology
https://www.readbyqxmd.com/read/29604130/structural-basis-for-tankyrase-rnf146-interaction-reveals-noncanonical-tankyrase-binding-motifs
#5
Paul A DaRosa, Rachel E Klevit, Wenqing Xu
Poly(ADP-ribosyl)ation (PARylation) catalyzed by the tankyrase enzymes (Tankyrase-1 and -2; a.k.a. PARP-5a and -5b) is involved in mitosis, telomere length regulation, GLUT-4 vesicle transport, and cell growth and differentiation. Together with the E3 ubiquitin ligase RNF146 (a.k.a. Iduna), tankyrases regulate the cellular concentrations of several important proteins including Axin, 3BP2, and angiomotins, which are key regulators of Wnt, Src and hippo signaling, respectively. These substrates of tankyrases are first PARylated and then ubiquitylated by RNF146, which is allosterically activated by binding to PAR polymer...
March 31, 2018: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/29602811/identification-of-proteins-required-for-precise-positioning-of-apc2-in-dendrites
#6
Alexis T Weiner, Dylan Y Seebold, Nick L Michael, Michelle Guignet, Chengye Feng, Brandon Follick, Brandon A Yusko, Nathan P Wasilko, Pedro Torres-Gutierrez, Melissa M Rolls
In Drosophila neurons, uniform minus-end-out polarity in dendrites is maintained in part by kinesin-2-mediated steering of growing microtubules at branch points. Apc links the kinesin motor to growing microtubule plus ends and Apc2 recruits Apc to branch points where it functions. Because Apc2 acts to concentrate other steering proteins to branch points, we wished to understand how Apc2 is targeted. From an initial broad candidate RNAi screen, we found Miro (a mitochondrial transport protein), Ank2, Axin, spastin and Rac1 were required to position Apc2-GFP at dendrite branch points...
March 30, 2018: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29596884/stip1-is-over-expressed-in-hepatocellular-carcinoma-and-promotes-the-growth-and-migration-of-cancer-cells
#7
Xiaoling Luo, Yuting Liu, Shijie Ma, Lei Liu, Rui Xie, Miaomiao Li, Peng Shen, Shaochuang Wang
Wnt/beta-catenin signaling is frequently activated in hepatocellular carcinoma (HCC). Better understanding the mechanism for its over-activation would help the therapy. In this study, we have shown that the stress-induced phosphoprotein 1 (STIP1) is up-regulated in the HCC tissues. Functional studies showed that STIP1 promoted the growth, colony formation and migration of cancer cells. However, knocking down the expression of STIP1 inhibited the growth, colony formation and migration of cancer cells. Molecular mechanism study showed that STIP1 interacted with Axin, enhanced the interaction between Axin and DVL2, thus activated beta-catenin/TCF signaling...
March 26, 2018: Gene
https://www.readbyqxmd.com/read/29564122/potential-signaling-pathways-as-therapeutic-targets-for-overcoming-chemoresistance-in-mucinous-ovarian-cancer
#8
Emiko Niiro, Sachiko Morioka, Kana Iwai, Yuki Yamada, Kenji Ogawa, Naoki Kawahara, Hiroshi Kobayashi
Cases of mucinous ovarian cancer are predominantly resistant to chemotherapies. The present review summarizes current knowledge of the therapeutic potential of targeting the Wingless (WNT) pathway, with particular emphasis on preclinical and clinical studies, for improving the chemoresistance and treatment of mucinous ovarian cancer. A review was conducted of English language literature published between January 2000 and October 2017 that concerned potential signaling pathways associated with the chemoresistance of mucinous ovarian cancer...
March 2018: Biomedical Reports
https://www.readbyqxmd.com/read/29561051/investigations-of-dynamic-amyloid-like-structures-of-the-wnt-signalling-pathway-by-solid-state-nmr
#9
M E Ward, M A Daniëls, E C van Kappel, M M Maurice, M Baldus
We report solid-state Nuclear Magnetic Resonance (ssNMR) studies on amyloid-like protein complexes formed by DIX domains that mediate key protein interactions in the Wnt signalling pathway. Our results provide insight into the 3D fold of the self-associated Axin-DIX domain and identify a potential lipid cofactor.
March 21, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29549930/pyrvinium-sensitizes-clear-cell-renal-cell-carcinoma-response-to-chemotherapy-via-casein-kinase-1%C3%AE-dependent-inhibition-of-wnt-%C3%AE-catenin
#10
Long Cui, Juan Zhao, Jingjing Liu
BACKGROUND: Aberrant Wnt/β-catenin activation has been shown to play essential roles in cancer, including renal cell carcinoma (RCC). In this work, we demonstrate that Wnt/β-catenin inhibition by a Food and Drug Administration-approved drug, pyrvinium, effectively targets clear cell RCC and enhances chemotherapy agent's efficacy. MATERIALS AND METHODS: We performed in vitro cell culture assays and in vivo xenograft tumor model to evaluate the effects of pyrvinium alone and its combination with paclitaxel, and analyzed the underlying mechanism(s) of pyrvinium's action in RCC...
March 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29525529/axin-deficiency-in-human-and-mouse-hepatocytes-induces-hepatocellular-carcinoma-in-the-absence-of-%C3%AE-catenin-activation
#11
Shirley Abitbol, Rajae Dahmani, Cédric Coulouarn, Bruno Ragazzon, Bernhard Mlecnik, Nadia Senni, Mathilde Savall, Pascale Bossard, Pierre Sohier, Valerie Drouet, Emilie Tournier, Florent Dumont, Romain Sanson, Julien Calderaro, Jessica Zucman-Rossi, Mireille Vasseur-Cognet, Pierre-Alexandre Just, Benoît Terris, Christine Perret, Hélène Gilgenkrantz
BACKGROUND & AIMS: The Wnt/β-catenin pathway is the most frequently deregulated pathway in hepatocellular carcinoma (HCC). Inactivating mutations of the gene encoding AXIN1, a known negative regulator of the Wnt/β-catenin signaling pathway, are observed in about 10% of HCCs. Whole-genome studies usually place HCC with AXIN1 mutations and CTNNB1 mutations in the group of tumors with Wnt/β-catenin activated program. However, it has been shown that HCCs with activating CTNNB1 mutations form a group of HCCs, with a different histology, prognosis and genomic signature to those with inactivating biallelic AXIN1 mutations...
June 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29516635/hmq-t-f2-exert-antitumour-effects-by-upregulation-of-axin-in-human-cervical-hela-cells
#12
Bingling Dai, Tianfeng Yang, Yujiao Ma, Nan Ma, Xianpeng Shi, Dongdong Zhang, Jie Zhang, Yanmin Zhang
Looking for novel, effective and less toxic therapies for cervical cancer is of significant importance. In this study, we reported that HMQ-T-F2(F2) significantly inhibited cell proliferation and transplantable tumour growth. Mechanistically, HMQ-T-F2 inhibited HeLa cell growth through repressing the expression and nuclear translocation of β-catenin, enhancing Axin expression, as well as downregulating the Wnt downstream targeted proteins. Knock-down of a checkpoint β-catenin by siRNA significantly attenuated HeLa cell proliferation...
May 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29480489/determining-ampk-activation-via-the-lysosomal-v-atpase-ragulator-axin-lkb1-axis
#13
Chen-Song Zhang, Mengqi Li, Yue Zong, Sheng-Cai Lin
Recent studies have revealed how AMPK is activated inside the cell and animal tissues: in response to low glucose, AXIN tethers LKB1, by virtue of their constitutive association, to AMPK located on the surface of late endosome/lysosome. Importantly, the lysosomal v-ATPase (vacuolar ATPase)-Ragulator complex, when primed by glucose starvation or concanamycin A, facilitates AXIN/LKB1 to interact with AMPK. Here, we describe the experimental procedures of the assays for detecting the translocation of AXIN/LKB1 or the assembly of the AXIN-based AMPK-activating complexes on the late endosome/lysosome...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29438981/pgam5-released-from-damaged-mitochondria-induces-mitochondrial-biogenesis-via-wnt-signaling
#14
Dominic B Bernkopf, Kowcee Jalal, Martina Brückner, Karl X Knaup, Marc Gentzel, Alexandra Schambony, Jürgen Behrens
Mitochondrial abundance is dynamically regulated and was previously shown to be increased by Wnt/β-catenin signaling. Pgam5 is a mitochondrial phosphatase which is cleaved by the rhomboid protease presenilin-associated rhomboid-like protein (PARL) and released from membranes after mitochondrial stress. In this study, we show that Pgam5 interacts with the Wnt pathway component axin in the cytosol, blocks axin-mediated β-catenin degradation, and increases β-catenin levels and β-catenin-dependent transcription...
April 2, 2018: Journal of Cell Biology
https://www.readbyqxmd.com/read/29432152/double-abdomen-in-a-short-germ-insect-zygotic-control-of-axis-formation-revealed-in-the-beetle-tribolium-castaneum
#15
Salim Ansari, Nicole Troelenberg, Van Anh Dao, Tobias Richter, Gregor Bucher, Martin Klingler
The distinction of anterior versus posterior is a crucial first step in animal embryogenesis. In the fly Drosophila , this axis is established by morphogenetic gradients contributed by the mother that regulate zygotic target genes. This principle has been considered to hold true for insects in general but is fundamentally different from vertebrates, where zygotic genes and Wnt signaling are required. We investigated symmetry breaking in the beetle Tribolium castaneum , which among insects represents the more ancestral short-germ embryogenesis...
February 20, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29408853/axin-phosphorylation-in-both-wnt-off-and-wnt-on-states-requires-the-tumor-suppressor-apc
#16
Ofelia Tacchelly-Benites, Zhenghan Wang, Eungi Yang, Hassina Benchabane, Ai Tian, Michael P Randall, Yashi Ahmed
The aberrant activation of Wnt signal transduction initiates the development of 90% of colorectal cancers, the majority of which arise from inactivation of the tumor suppressor Adenomatous polyposis coli (APC). In the classical model for Wnt signaling, the primary role of APC is to act, together with the concentration-limiting scaffold protein Axin, in a "destruction complex" that directs the phosphorylation and consequent proteasomal degradation of the transcriptional activator β-catenin, thereby preventing signaling in the Wnt-off state...
February 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29391809/high-frequency-deregulated-expression-of-wnt-signaling-pathway-members-in-breast-carcinomas
#17
Zahid Khan, Maha Arafah, Jilani Purusottapatnam Shaik, Alka Mahale, Mohammad Saud Alanazi
Purpose: Breast carcinoma is the most common malignancy and leading cause of cancer-related deaths in women worldwide including Saudi Arabia. Breast cancer in Saudi women develops at a much early age with median age of onset of 49 years compared to 62 years observed in patients from USA. Aberrations in wingless and integration site growth factor (Wnt) signaling pathway have been pathologically implicated in development of breast cancers and hence its role was examined in Saudi patients...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29353209/mir-182-promotes-prostate-cancer-progression-through-activating-wnt-%C3%AE-catenin-signal-pathway
#18
Dawei Wang, Guoliang Lu, Yuan Shao, Da Xu
Although prostate cancer can be surgical excised and effectively treated by androgen-deprivation therapy, radiotherapy, or chemotherapy, management of patients with advanced or drug-resistance prostate cancer stills remains a big trouble. Accumulated evidence indicated that miR-182 and Wnt/β-catenin function as tumor oncogene in the progression of a variety of tumors. However, little is known about how miR-182 regulates β-catenin signal molecular and impacts on the tumorigenesis of human prostate cancer. In this study, employing the analyses of qRT-PCR, we found that prostate cancer tissues expressed much more miR-182 than non-cancer tissues did...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29353205/wisp3-prevents-fibroblast-myofibroblast-transdifferentiation-in-nrk-49f-cells
#19
Yang Yi, Jun Ma, Lu Jianrao, Hangqing Wang, Yingdan Zhao
CCN family, a group of six extracellular matrix-associated proteins, plays an important role in fibrosis. WISP3 has addressed as a pro-fibrotic molecule in the development of human lung fibrosis. However, whether WISP3 involved in the activation and proliferation of renal fibroblast, and ultimately inhibited fibroblast-myofibroblast transdifferentiation remained unknown. Herein, we found that down-regulated WISP3 was involved in the fibrogenesis of rat renal NRK-49F cells induced by transforming growth (TGF-β1), which was further confirmed in a rat renal fibrosis induced by unilateral ureteral obstruction (UUO)...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29351069/metazoan-parasite-fauna-of-migrating-common-garfish-belone-belone-l-in-the-baltic-sea
#20
Patrick Unger, Kilian Neubert, Harry W Palm
A total of 35 common garfish, Belone belone (Linnaeus, 1761), were studied for metazoan parasites on their spawning grounds in the western Baltic Sea. Nine parasite species were found, and six new locality records could be established for German coastal waters (Axine belones, Monogenea; Proteocephalus sp., Cestoda; Anisakis simplex (s.s.), Contracaecum rudolphii A and Hysterothylacium aduncum, Nematoda; Echinorhynchus gadi, Acanthocephala). For the first time, the marine ectoparasite A. belones was recorded from the gills of garfish inside the Baltic Sea, indicating its ability to survive the spawning migration as well as the brackish water conditions at its reproduction grounds...
March 26, 2018: Acta Parasitologica
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