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https://www.readbyqxmd.com/read/28107765/lower-adenoma-miss-rate-with-fuse-vs-conventional-colonoscopy-with-proximal-retroflexion-a-randomized-back-to-back-trial
#1
Ioannis S Papanikolaou, Periklis Apostolopoulos, Georgios Tziatzios, Erasmia Vlachou, Athanasios D Sioulas, Dimitrios Polymeros, Andreas Karameris, Ioannis Panayiotides, Georgios Alexandrakis, George D Dimitriadis, Konstantinos Triantafyllou
Background and study aims Full-spectrum colonoscopy (FSC) promises to increase adenoma detection by providing a wider field of view. The aim of this study was to compare adenoma miss rates of FSC with those of conventional colonoscopy complemented by right-colon re-examination using scope retroflexion (CC/R). Patients and methods At two tertiary endoscopy facilities, patients who were scheduled for colonoscopy for the assessment of symptoms or for colorectal cancer screening/surveillance were randomized (1:1) to undergo same-day, back-to-back colonoscopies (FSC or CC/R first), performed by one of five endoscopists who had documented adenoma detection rates > 35 %...
January 20, 2017: Endoscopy
https://www.readbyqxmd.com/read/28107763/virtual-chromoendoscopy-i-scan-detects-more-polyps-in-patients-with-lynch-syndrome-a-randomized-controlled-crossover-trial
#2
Raf Bisschops, Sabine Tejpar, Hilde Willekens, Gert De Hertogh, Eric Van Cutsem
: Background and study aims (Virtual) chromoendoscopy detects more polyps than standard white-light endoscopy in patients with Lynch syndrome. Previous back-to-back trials did not randomize for the examination order, creating a possible bias in favor of chromoendoscopy. We aimed to assess the difference in polyp detection between high definition white-light endoscopy (HD-WLE) and virtual chromoendoscopy with I-SCAN in patients with Lynch syndrome. Patients and methods In this prospective, controlled trial, patients were randomized to either HD-WLE followed by I-SCAN (Group 1; n = 31) or I-SCAN followed by HD-WLE (Group 2; n = 30)...
January 20, 2017: Endoscopy
https://www.readbyqxmd.com/read/28107760/intraneural-ganglion-cyst-of-the-ulnar-nerve-in-an-unusual-location-a-case-report
#3
Ufuk Öztürk, Ahmet Salduz, Mehmet Demirel, Tuna Pehlivanoğlu, Sevan Sivacioğlu
INTRODUCTION: Intraneural ganglion cysts are benign, mucinous, non-neoplastic lesions of the peripheral nerves. While the most common location of intraneural ganglion cysts is the ulnar nerve and its branches, intraneural ganglion cyst involving the superficial branch of the ulnar nerve has not yet been reported. PRESENTATION OF CASE: A-25-year-old woman presented with pain and a palpable mass in the hypothenar region of the volar side of her right hand. Her neuromuscular examination was normal...
January 5, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28107757/piezosurgery-a-safe-technique-for-inferior-alveolar-nerve-mobilization-in-surgical-correction-of-hemimandibular-hyperplasia-review-of-the-literature-and-case-report
#4
Amel S Eltayeb, Abdelnasir G Ahmad
INTRODUCTION: Piezoelectric bone surgery is a relatively new alternative for bone-related procedures in oral and maxillofacial surgery. It represents an innovative technique as it offers the maxillofacial surgeon the opportunity to make precise bone cuts without damaging any soft tissue and providing a blood less surgical field. Correction of facial asymmetries is still a major problem in need of an adequate solution. Neurosensory damage to the inferior alveolar nerve can be an adverse effect of surgical correction of hemimandibular hyperplasia...
December 30, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28107750/effect-of-clinically-approved-hdac-inhibitors-on-plasmodium-leishmania-and-schistosoma-parasite-growth
#5
Ming Jang Chua, Megan S J Arnold, Weijun Xu, Julien Lancelot, Suzanne Lamotte, Gerald F Späth, Eric Prina, Raymond J Pierce, David P Fairlie, Tina S Skinner-Adams, Katherine T Andrews
Malaria, schistosomiasis and leishmaniases are among the most prevalent tropical parasitic diseases and each requires new innovative treatments. Targeting essential parasite pathways, such as those that regulate gene expression and cell cycle progression, is a key strategy for discovering new drug leads. In this study, four clinically approved anti-cancer drugs (Vorinostat, Belinostat, Panobinostat and Romidepsin) that target histone/lysine deacetylase enzymes were examined for in vitro activity against Plasmodium knowlesi, Schistosoma mansoni, Leishmania amazonensis and L...
December 23, 2016: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/28107746/induced-differentiation-of-human-gingival-fibroblasts-into-vsmc-like-cells
#6
Xuqian Liu, Jie Wang, Fusheng Dong, Hexiang Li, Yali Hou
Vascular smooth muscle cells (VSMCs) are major component of the vascular wall, and they play an essential role in maintaining the basic physiological function and stable structure of the vascular wall. In the present study, human gingival fibroblasts (HGFs) were cultured and induced into VSMC-like cells in vitro to confirm that HGFs with properties of stem cells have the potential for differentiation. The epithelium isolated from patients was extracted from normal human gingiva consisting of epithelium and connective tissue...
January 17, 2017: Differentiation; Research in Biological Diversity
https://www.readbyqxmd.com/read/28107743/high-sensitivity-four-layer-polymer-fiber-optic-evanescent-wave-sensor
#7
Xin Xin, Nianbing Zhong, Qiang Liao, Yanyan Cen, Ruohua Wu, Zhengkun Wang
We present a novel four-layer structure consisting of bottom, second, third, and surface layers in the sensing region, for a D-shaped step-index fiber-optic evanescent wave (FOEW) sensor. To reduce the background noise, the surface of the longitudinal section in the D-shaped region is coated with a light-absorbing film. We check the morphologies of the second and surface layers, examine the refractive indices (RIs) of the third and surface layers, and analyze the composition of the surface layer. We also investigate the effects of the thicknesses and RIs of the third and surface layers and the LA film on the light transmission and sensitivity of the FOEW sensors...
January 11, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28107741/building-related-symptoms-are-linked-to-the-in-vitro-toxicity-of-indoor-dust-and-airborne-microbial-propagules-in-schools-a-cross-sectional-study
#8
J T Salin, M Salkinoja-Salonen, P J Salin, K Nelo, T Holma, P Ohtonen, H Syrjälä
INTRODUCTION: Indoor microbial toxicity is suspected to cause some building-related symptoms, but supporting epidemiological data are lacking. OBJECTIVE: We examined whether the in vitro toxicity of indoor samples from school buildings was associated with work-related health symptoms (building-related symptoms, BRS). METHODS: Administrators of the Helsinki City Real Estate Department selected 15 schools for the study, and a questionnaire on symptoms connected to work was sent to the teachers in the selected schools for voluntary completion...
January 17, 2017: Environmental Research
https://www.readbyqxmd.com/read/28107730/systemic-atherosclerosis-and-voiding-symptom
#9
A Ozgur Yeniel, A Mete Ergenoglu, Reci Meseri, Anıl Ari, Ceren Sancar, Ismail Mete Itil
OBJECTIVE: To evaluate the effect of atherosclerosis on the storage and voiding symptoms of the bladder in women with overactive bladder (OAB). STUDY DESIGN: We retrospectively reviewed the charts of women with OAB who were evaluated between 2013 and 2015 in our urogynecology unit. Charts were assessed for history, examination findings, urinary diary, quality of life (QOL) questionnaires, urodynamic studies (UDSs), and four main risk factors for atherosclerosis: hypertension, diabetes mellitus, smoking, and hyperlipidemia...
January 9, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28107727/neural-correlates-of-subliminally-presented-visual-sexual-stimuli
#10
Martina Wernicke, Corinna Hofter, Kirsten Jordan, Peter Fromberger, Peter Dechent, Jürgen L Müller
In the context of forensic psychiatry, it is crucial that diagnoses of deviant sexual interests are resistant to manipulation. In a first attempt to promote the development of such tools, the current fMRI study focusses on the examination of hemodynamic responses to preferred, in contrast to non-preferred, sexual stimuli with and without explicit sexual features in 24 healthy heterosexual subjects. The subliminal stimulus presentation of sexual stimuli could be a new approach to reduce vulnerability to manipulation...
January 17, 2017: Consciousness and Cognition
https://www.readbyqxmd.com/read/28107690/time-domain-nmr-as-a-new-process-monitoring-method-for-characterization-of-pharmaceutical-hydrates
#11
Stefanie Ulrike Schumacher, Benno Rothenhäusler, Alf Willmann, Jürgen Thun, Regina Moog, Martin Kuentz
Hydrates are of great pharmaceutical relevance and even though they have been characterized thoroughly by various analytical techniques, there is barely literature available on molecular mobility of the hydrate water studied by NMR relaxation in the time domain. The aim of this work was to examine the possibility of differentiating hydration states of drugs by (1)H time domain NMR (TD-NMR) regarding spin-spin and spin-lattice relaxation times (T2 and T1) using benchtop equipment. Caffeine and theophylline were selected as model compounds and binary mixtures of hydrate to anhydrate were analyzed for each drug using a spin echo and inversion recovery pulse sequence...
January 9, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28107682/happy-faces-sad-faces-emotion-understanding-in-toddlers-and-preschoolers-with-language-impairments
#12
Carolien Rieffe, Carin H Wiefferink
BACKGROUND: The capacity for emotion recognition and understanding is crucial for daily social functioning. We examined to what extent this capacity is impaired in young children with a Language Impairment (LI). In typical development, children learn to recognize emotions in faces and situations through social experiences and social learning. Children with LI have less access to these experiences and are therefore expected to fall behind their peers without LI. METHOD: In this study, 89 preschool children with LI and 202 children without LI (mean age 3 years and 10 months in both groups) were tested on three indices for facial emotion recognition (discrimination, identification, and attribution in emotion evoking situations)...
January 17, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/28107681/enhancement-of-numeric-cognition-in-children-with-low-achievement-in-mathematic-after-a-non-instrumental-musical-training
#13
Fabiana Silva Ribeiro, Flávia H Santos
Studies suggest that musical training enhances spatial-temporal reasoning and leads to greater learning of mathematical concepts. The aim of this prospective study was to verify the efficacy of a Non-Instrumental Musical Training (NIMT) on the Numerical Cognition systems in children with low achievement in math. For this purpose, we examined, with a cluster analysis, whether children with low scores on Numerical Cognition would be grouped in the same cluster at pre and post-NIMT. Participants were primary school children divided into two groups according to their scores on an Arithmetic test...
January 17, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/28107680/a-randomized-clinical-trial-of-buprenorphine-for-prisoners-findings-at-12-months-post-release
#14
Michael S Gordon, Timothy W Kinlock, Robert P Schwartz, Kevin E O'Grady, Terrence T Fitzgerald, Frank J Vocci
BACKGROUND: This study examined whether starting buprenorphine treatment prior to prison and after release from prison would be associated with better drug treatment outcomes and whether males and females responded differently to the combination of in-prison treatment and post-release service setting. METHODS: Study design was a 2 (In-Prison Treatment: Condition: Buprenorphine Treatment: vs. Counseling Only)×2 [Post-Release Service Setting Condition: Opioid Treatment: Program (OTP) vs...
January 11, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28107679/meta-analysis-of-the-relationship-between-impulsivity-and-substance-related-cognitive-biases
#15
REVIEW
Daniel Leung, Petra K Staiger, Melissa Hayden, Jarrad A G Lum, Kate Hall, Victoria Manning, Antonio Verdejo-Garcia
BACKGROUND: Evidence indicates that substance-related cognitive biases (attentional, memory, and approach bias) contribute to the maintenance and development of substance misuse. Impulsivity has been suggested to influence how cognitive biases contribute to substance misuse, possibly by biasing incentive salience attribution processes. However, the strength and moderators of the relationship between impulsivity and substance-related cognitive biases has yet to be empirically examined...
January 5, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28107674/mitochondrial-serine-hydroxymethyltransferase-2-is-a-potential-diagnostic-and-prognostic-biomarker-for-human-glioma
#16
Bo Wang, Wei Wang, ZhiZhong Zhu, XueBin Zhang, Fan Tang, Dong Wang, Xi Liu, XiaoLing Yan, Hao Zhuang
OBJECTIVE: Scholars have gradually come to appreciate the relevance of serine and glycine metabolism. Recently, researchers have discovered that mitochondrial serine hydroxymethyltransferase 2 (SHMT2) is overexpressed in various types of cancer. However, the function of SHMT2 in glioma is not clear. In this study, we sought to examine the expression of SHMT2 in glioma, the association between SHMT2 expression and clinicopathological characteristics, and the association of SHMT2 expression with prognosis in glioma patients...
January 16, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28107658/validation-of-a-personalized-curved-muscle-model-of-the-lumbar-spine-during-complex-dynamic-exertions
#17
Jaejin Hwang, Gregory G Knapik, Jonathan S Dufour, Thomas M Best, Safdar N Khan, Ehud Mendel, William S Marras
Previous curved muscle models have typically examined their robustness only under simple, single-plane static exertions. In addition, the empirical validation of curved muscle models through an entire lumbar spine has not been fully realized. The objective of this study was to empirically validate a personalized biologically-assisted curved muscle model during complex dynamic exertions. Twelve subjects performed a variety of complex lifting tasks as a function of load weight, load origin, and load height. Both a personalized curved muscle model as well as a straight-line muscle model were used to evaluate the model's fidelity and prediction of three-dimensional spine tissue loads under different lifting conditions...
January 9, 2017: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/28107654/examining-the-link-between-nonmedical-use-of-sedatives-tranquilizers-and-pain-relievers-with-dispositions-toward-impulsivity-among-college-students
#18
Brittany E Blanchard, Angela K Stevens, Andrew K Littlefield, Amelia E Talley, Jennifer L Brown
BACKGROUND: The association between impulsive dispositions and the use of the central nervous system (CNS) depressant alcohol has been examined extensively; however, the links between other depressant use (sedatives, tranquilizers, and pain relievers) and impulsivity have been less studied, and findings have been equivocal. This may be due, in part, to varying operationalizations of "impulsivity," as well as issues related to the lumping versus splitting of various depressant substances when assessing use...
January 6, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28107632/structural-changes-in-acetophenone-fluid-films-as-a-function-of-nano-scale-thickness
#19
Samantha L Nania, Scott K Shaw
We report experimental observations of a developing fluid-solid interface by examining acetophenone films of varying thicknesses, supported on solid silver substrates. A dynamic wetting technique provides experimental control of fluid film thickness as a function of rotational velocity. Ellipsometry and infrared reflection absorption spectroscopy data are analyzed to provide absolute film thickness and details of the changing chemical environment for varying film thickness. This data is compared to theoretical models that predict fluid film thicknesses based on physical-chemical properties of the acetophenone/silver pair...
January 20, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28107623/dna-advanced-glycation-end-products-dna-ages-are-elevated-in-urine-and-tissue-in-an-animal-model-of-type-2-diabetes
#20
Richard Jaramillo, Sarah C Shuck, Yin S Chan, Xueli Liu, Steven E Bates, Punnajit P Lim, Daniel Tamae, Sandrine Lacoste, Timothy R O'Connor, John Stephen Termini
More precise identification and treatment monitoring of prediabetic/diabetic individuals will require additional biomarkers to complement existing diagnostic tests. Candidates include hyperglycemia-induced adducts such as advanced glycation end products (AGEs) of proteins, lipids, and DNA. The potential for DNA-AGEs as diabetic biomarkers was examined in a longitudinal study using the Leprdb/db animal model of metabolic syndrome. The DNA-AGE, N2-(1-carboxyethyl)-2´-deoxyguanosine (CEdG) was quantified by mass spectrometry using isotope dilution from urine and tissue of hyperglycemic and normoglycemic mice...
January 20, 2017: Chemical Research in Toxicology
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