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https://www.readbyqxmd.com/read/29241297/selecting-a-suitable-surgical-treatment-for-hepatic-angiomyolipoma-a-retrospective-analysis-of-92-cases
#1
Xianwei Yang, Chuanfen Lei, Yiwen Qiu, Shu Shen, Changli Lu, Lunan Yan, Wentao Wang
BACKGROUND: Hepatic angiomyolipoma (HAML) is a rare and difficult-to-diagnose liver tumour. The aim of this study was to summarize experiences in the management of HAML and to recommend a practical treatment strategy. METHODS: We retrospectively studied 92 patients who were diagnosed with HAML and analysed the clinical presentation, histopathological features and treatment of the tumours encountered at our institute from May 2009 to June 2016. RESULTS: The patients included 67 females and 25 males who underwent at least one radiographic examination...
December 14, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29241277/dual-energy-computed-tomography-in-musculoskeletal-imaging-with-focus-on-fragility-fractures-of-the-pelvis
#2
Carsten Hackenbroch, Hans-Joachim Riesner, Patricia Lang, Fabian Stuby, Meinrad Beer, Benedikt Friemert, Hans-Georg Palm
Dual energy computed tomography (DECT) is a constantly evolving technology, which opens up new diagnostic possibilities. It is particularly valuable for musculoskeletal (MSK) imaging. Due to the lack of recognition and availability of dual energy scanners, routine use is only established in a few centres. The intention of this review is to show the possibilities and fields of applications of the DECT in MSK imaging, as well as to describe technical principles and typical indications. We mainly focus on the use of DECT in the context of fragility fractures of the pelvis...
December 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/29241258/-changes-of-motor-balance-in-the-course-of-an-inpatient-psychosomatic-rehabilitation
#3
ElisabethJohanna Grub, Georg Wydra, Michael Käfer, Volker Köllner
Aim of the study For many rehabilitants both the motor balance and the feeling of being emotionally stable and in balance are essential preconditions for participation in employment and society. The goal of this study was to capture changes in motor balance in the course of an inpatient psychosomatic rehabilitation and to set them in relation to changes in mental variables. Methods 118 patients of a psychosomatic clinic (49.3±8.6 years; 75.4 % women) were examined at the beginning and the end of rehabilitation...
December 2017: Die Rehabilitation
https://www.readbyqxmd.com/read/29241222/flavopiridol-enhances-abt-199-sensitivity-in-unfavourable-risk-multiple-myeloma-cells-in-vitro-and-in-vivo
#4
Liang Zhou, Yu Zhang, Deepak Sampath, Joel Leverson, Yun Dai, Maciej Kmieciak, Matthew Nguyen, Robert Z Orlowski, Steven Grant
BACKGROUND: The BCL-2-specific BH3-mimetic ABT-199 (venetoclax) has been reported to be principally active against favourable-risk multiple myeloma (MM) cells, prompting efforts to extend its activity to include more resistant, higher-risk MM subsets. METHODS: Effects of the CDK9 inhibitor flavopiridol (FP; alvocidib) on responses to ABT-199 were examined in MM cells. Cell death and protein expression were evaluated by western blot and immunofluorescence. Xenograft models were used to study combination effects in vivo...
December 14, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29241214/nasalance-variability-in-3-to-5-year-old-children-during-production-of-speech-stimulus-in-three-vowel-contexts
#5
Seunghee Ha, Ilsan Shin
OBJECTIVE: The purpose of this study was to determine whether age and vowel contexts influence test-retest nasalance score variability in typically developing Korean children. PARTICIPANTS: Forty-five 3- to 5-year-old children with normal speech and resonance participated in the study. METHODS: All subjects were asked to repeat three 4-syllable speech stimuli in high, low, or mixed vowel contexts twice after the examiner. An immediate test-retest nasalance score was assessed with no headgear change...
December 14, 2017: Folia Phoniatrica et Logopaedica
https://www.readbyqxmd.com/read/29241208/exosomes-from-mir-126-overexpressing-adscs-are-therapeutic-in-relieving-acute-myocardial-ischaemic-injury
#6
Qiancheng Luo, Dongfeng Guo, Guorong Liu, Guo Chen, Min Hang, Mingming Jin
BACKGROUND/AIMS: Recent studies have indicated that exosomes play an important role in adipose-derived stem cell (ADSC) transplant-mediated ischaemic heart disease therapy. However, the treatment effect is not obvious. The aim of this study is to investigate whether ADSC-derived exosomes enriched with microRNA (miR)-126 have a more protective effect on acute myocardial infarction (AMI). METHODS: Exosomes were characterized by transmission electron microscopy, and the exosome particles were further examined using nanoparticle tracking analyses...
December 12, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29241192/microrna-92a-3p-regulates-aggrecanase-1-and-aggrecanase-2-expression-in-chondrogenesis-and-il-1%C3%AE-induced-catabolism-in-human-articular-chondrocytes
#7
Guping Mao, Peihui Wu, Ziji Zhang, Zhiqi Zhang, Weiming Liao, Yukang Li, Yan Kang
BACKGROUND/AIMS: Aggrecanase-1 (ADAMTS-4) and aggrecanase-2 (ADAMTS-5) are secreted enzymes belonging to the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family that play significant roles in the progression of osteoarthritis (OA). Here, we aimed to determine whether the expression of ADAMTS-4/5 in chondrogenesis and inflammation is regulated by microRNA-92a-3p (miR-92a-3p). METHODS: MiR-92a-3p and ADAMTS-4/5 expressions were determined by quantitative polymerase chain reaction (qPCR)...
November 3, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29241186/strengthening-gastric-cancer-therapy-by-trastuzumab-conjugated-nanoparticles-with-simultaneous-encapsulation-of-anti-mir-21-and-5-fluorouridine
#8
Nan Hu, Jun Feng Yin, Ze Ji, Yidong Hong, Puyuan Wu, Baoxiang Bian, Ziyan Song, Rutian Li, Qin Liu, Fenglei Wu
BACKGROUND/AIMS: MicroRNA-21 is an oncogenic miR (oncomiR) frequently elevated in gastric cancer (GC). Overexpression of miR-21 decreases the sensitivity of GC cells to 5-fluorouridine (5-Fu) and trastuzumab, a humanized monoclonal antibody targeting human epidermal growth factor receptor 2 (HER2). Receptor-mediated endocytosis plays a crucial role in the delivery of biotherapeutics including anti-miRNA oligonucleotides (AMOs). This study is a continuation of earlier findings involving poly(ε-caprolactone) (PCL)-poly (ethylene glycol) (PEG) nanoparticles (PEG-PCL NPs), which were coated with trastuzumab to target GC with HER2 receptor over-expression using anti-miRNA-21 (AMO-21) and 5-Fu...
December 12, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29241163/diagnosis-and-management-of-necrotizing-enterocolitis-an-international-survey-of-neonatologists-and-pediatric-surgeons
#9
Mélanie Valpacos, Delphine Arni, Amy Keir, Ann Aspirot, James C H Wilde, Spencer Beasley, Daniele De Luca, Riccardo E Pfister, Oliver Karam
BACKGROUND: Necrotizing enterocolitis (NEC) is a serious complication of prematurity. Currently, there is limited evidence to guide investigation and treatment strategies. OBJECTIVES: To evaluate the parameters used to diagnose or exclude NEC, and to identify differences between neonatologists and pediatric surgeons. METHODS: A scenario-based survey was sent to neonatologists and pediatric surgeons. RESULTS: 173 physicians from 26 countries completed the survey (55% neonatologists and 45% pediatric surgeons)...
December 15, 2017: Neonatology
https://www.readbyqxmd.com/read/29241137/improving-post-detonation-energetics-residues-estimations-for-the-life-cycle-environmental-assessment-process-for-munitions
#10
Michael Walsh, Brian Gullett, Marianne Walsh, Matthew Bigl, Johanna Aurell
The Life Cycle Environmental Assessment (LCEA) process for military munitions tracks possible environmental impacts incurred during all phases of the life of a munition. The greatest energetics-based emphasis in the current LCEA process is on manufacturing. A review of recent LCEAs indicates that energetics deposition on ranges from detonations and disposal during training is only peripherally examined through assessment of combustion products derived from closed-chamber testing or models. These assessments rarely report any measurable energetic residues...
November 15, 2017: Chemosphere
https://www.readbyqxmd.com/read/29241133/oxidation-of-%C3%AE-blockers-by-birnessite-kinetics-mechanism-and-effect-of-metal-ions
#11
Yong Chen, Xiye Lu, Lu Liu, Dong Wan, Huabin Chen, Danna Zhou, Virender K Sharma
Manganese dioxides are ubiquitous in natural waters, soils, and sediments and play an important role in oxidative transformation of organic pollutants. This work presents the kinetics of the oxidation of selected β-blockers, betaxolol, metoprolol, and atenolol by birnessite (δ-MnO2) as a function of concentration of the β-blocker, dosage of δ-MnO2, and solution pH. The values of pseudo-first-order rate constants (kobs) of β-blockers decreased in the order betaxolol > atenolol > metoprolol, which was positively correlated with their acid dissociation constants (Ka)...
December 6, 2017: Chemosphere
https://www.readbyqxmd.com/read/29241129/improving-biocathode-community-multifunctionality-by-polarity-inversion-for-simultaneous-bioelectroreduction-processes-in-domestic-wastewater
#12
Hui Yun, Bin Liang, Deyong Kong, Aijie Wang
Bioelectrochemical systems (BESs) have been tentatively applied for wastewater treatment processes, but the complex composition of wastewater could lead to difficulties in establishing functional biofilm or result in performance instability. Few studies have investigated the enrichment of biocathode with domestic wastewater (DW) and the function. A biocathode with multi-pollutant removal capabilities was enriched based on polarity inverted bioanode, which was established with DW. The biocathode function was examined using model pollutants (nitrate, nitrobenzene and Acid Orange 7) supplemented as sole or mixed electron acceptors...
December 7, 2017: Chemosphere
https://www.readbyqxmd.com/read/29241116/-body-self-in-the-shadow-of-childhood-sexual-abuse-the-long-term-implications-of-sexual-abuse-for-male-and-female-adult-survivors
#13
Anat Talmon, Karni Ginzburg
Childhood sexual abuse (CSA) may have long-term negative outcomes for victims' body representations. In this study we examined a model in which the relation between CSA and an individual's discomfort when in close proximity to others is mediated by disrupted body boundaries, and the relation between CSA and body shame is mediated by body self-objectification. Since most of these variables were conceptualized and assessed primarily among women, gender differences regarding the proposed model were examined. Study participants were 843 college/university students (536 women and 307 men)...
December 11, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/29241115/predictors-of-justice-system-involvement-maltreatment-and-education
#14
Angela A Robertson, Courtney S Walker
Decades of research have established that experience of abuse and/or neglect in childhood is related to negative outcomes, such as juvenile delinquency. Existing research has shown that involvement in child welfare services is also related to juvenile delinquency, particularly for children who are victims of neglect. Research has also identified educational factors such as chronic absenteeism as significant predictors of involvement in the juvenile justice system. However, little research has investigated the combined influence of educational factors, child abuse, and involvement in child protective services on justice system involvement...
December 11, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/29241113/concentrating-molasses-distillery-wastewater-using-biomimetic-forward-osmosis-fo-membranes
#15
N Singh, I Petrinic, C Hélix-Nielsen, S Basu, M Balakrishnan
Treatment of sugarcane molasses distillery wastewater is challenging due to the presence of complex phenolic compounds (melanoidins and polyphenols) having antioxidant properties. Due to zero liquid discharge regulations, Indian distilleries continue to explore effective treatment options. This work examines the concentration of distillery wastewater by forward osmosis (FO) using aquaporin biomimetic membranes and magnesium chloride hexahydrate (MgCl2.6H2O) as draw solution. The operational parameters viz. feed solution and draw solution flow rate and draw solution concentration were optimized using 10% v/v melanoidins model feed solution...
December 8, 2017: Water Research
https://www.readbyqxmd.com/read/29241106/differentials-and-trends-in-emergency-department-visits-due-to-alcohol-intoxication-and-co-occurring-conditions-among-students-in-a-u-s-public-university
#16
Duc Anh Ngo, Nassima Ait-Daoud, Saumitra V Rege, Christopher Ding, Lauren Gallion, Susan Davis, Christopher P Holstege
BACKGROUND: Few studies have explored the epidemiology of students presenting to the emergency department (ED) as a consequence of hazardous drinking. This study examined differentials and trends in ED visits following alcohol intoxication and co-occurring conditions among students presenting to a major U.S. university health system. METHODS: The ED electronic medical records from academic years 2010-2015 were queried for student visits and their records were linked to the university's student admission datasets...
December 9, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29241103/prevalence-and-correlates-of-benzodiazepine-use-and-misuse-among-young-adults-who-use-prescription-opioids-non-medically
#17
Benjamin A Bouvier, Katherine M Waye, Beth Elston, Scott E Hadland, Traci C Green, Brandon D L Marshall
BACKGROUND: Benzodiazepine use dramatically increases the risk of unintentional overdose among people who use opioids non-medically. However, little is known about the patterns of co-occurring benzodiazepine and opioid use among young adults in the United States. METHODS: The Rhode Island Young Adult Prescription Drug Study (RAPiDS) was a cross-sectional study from January 2015-February 2016. RAPiDS recruited 200 young adults aged 18-29 who reported past 30-day non-medical prescription opioid (NMPO) use...
December 7, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29241091/the-effectiveness-of-group-otago-exercise-program-on-physical-function-in-nursing-home-residents-older-than-65years-a-randomized-controlled-trial
#18
Mirjana Kocic, Zorica Stojanovic, Dejan Nikolic, Milica Lazovic, Rade Grbic, Lidija Dimitrijevic, Marina Milenkovic
AIM: To examine whether the 6-months group-based Otago exercise program is more effective than usual care on physical function and functional independence in nursing home residents older than 65 years. METHODS: An observer-blind randomized controlled study included 77 independently walking, cognitively unimpaired residents aged 78.4±7.6years, of which 66.2% were female. Physical function was assessed at baseline, after 3 and 6months of the Otago exercise program by three performance tests: Berg Balance Scale (BBS), Timed Up and Go (TUG) and Chair Rising Test (CRT), and functional independence by the motor Functional Independence Measure (mFIM)...
December 10, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/29241082/the-effect-of-n-acetylcysteine-and-working-memory-training-on-cocaine-use-craving-and-inhibition-in-regular-cocaine-users-correspondence-of-lab-assessments-and-ecological-momentary-assessment
#19
Mieke H J Schulte, Reinout W Wiers, Wouter J Boendermaker, Anna E Goudriaan, Wim van den Brink, Denise S van Deursen, Malte Friese, Emily Brede, Andrew J Waters
INTRODUCTION: Effective treatment for cocaine use disorder should dampen hypersensitive cue-induced motivational processes and/or strengthen executive control. Using a randomized, double-blind, placebo-controlled intervention, the primary aim of this study was to investigate the effect of N-Acetylcysteine (NAC) and working memory (WM)-training to reduce cocaine use and craving and to improve inhibition assessed in the laboratory and during Ecological Momentary Assessment (EMA). The second aim was to examine correspondence between laboratory and EMA data...
December 11, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/29241081/does-misuse-lead-to-a-disorder-the-misuse-of-prescription-tranquilizer-and-sedative-medications-and-subsequent-substance-use-disorders-in-a-u-s-longitudinal-sample
#20
C J Boyd, B West, S E McCabe
OBJECTIVES: We used two waves of National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) data and examined whether the misuse of prescription tranquilizers or sedatives at Wave 1 was associated with either continued misuse, tranquilizer/sedative use disorder, or other substance use disorder (SUD) at Wave 2. METHODS: Prospective data were analyzed from structured diagnostic interviews using the Alcohol Use disorders and Associated Disabilities Interview Schedule: DSM-IV Version (AUDADIS-DSM-IV)...
November 28, 2017: Addictive Behaviors
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