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https://www.readbyqxmd.com/read/29452440/operative-time-and-flap-failure-in-unilateral-and-bilateral-free-flap-breast-reconstruction
#1
Alvin C Kwok, Kyle Edwards, Daniel P Donato, Eric Tatro, Yizhe Xu, Angela P Presson, Jayant P Agarwal
BACKGROUND: There is an increasing trend toward bilateral breast reconstruction. Using the National Surgical Quality Improvement Program (NSQIP) database, we sought to understand the association between unilateral and bilateral free flap breast reconstruction and operative time and flap failure. METHODS: We selected a cohort of patients undergoing free flap breast reconstruction using the 2005 to 2010 NSQIP database. Cases were divided into unilateral and bilateral reconstruction...
February 16, 2018: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/29452400/sleep-quality-in-well-defined-lyme-disease-a-clinical-cohort-study-in-maryland
#2
Eric R Weinstein, Alison W Rebman, John N Aucott, Doug Johnson-Greene, Kathleen T Bechtold
Study Objectives: Lyme disease (LD) is the most common vector-borne disease in the United States. Approximately 5-15% of patients develop post-antibiotic treatment symptoms termed post-treatment LD syndrome (PTLDS). The primary objective of this study was to examine and quantify sleep quality among patients with early Lyme disease during the acute and convalescent periods, including among the subset who met criteria for PTLDS. Methods: This paper draws from a clinical cohort study of early LD participants (n=122) and a sub-cohort of individuals who later met criteria for PTLDS (n=6)...
February 14, 2018: Sleep
https://www.readbyqxmd.com/read/29452389/parity-associated-with-telomere-length-among-us-reproductive-age-women
#3
A Z Pollack, K Rivers, K A Ahrens
STUDY QUESTION: Is telomere length related to parity among a nationally representative sample of US reproductive age women? SUMMARY ANSWER: History of live birth was associated with shorter telomere length. WHAT IS KNOWN ALREADY: Shorter telomeres have been linked with a range of chronic health conditions and mortality and parity has been associated with health indicators. However, there is a lack of research on how parity relates to telomere length...
February 14, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29452380/relative-vaccine-effectiveness-of-high-dose-versus-standard-dose-influenza-vaccines-among-veterans-health-administration-patients
#4
Yinong Young-Xu, Robertus Van Aalst, Salaheddin M Mahmud, Kenneth J Rothman, Julia Thornton Snider, Daniel Westreich, Vincent Mor, Stefan Gravenstein, Jason K H Lee, Edward W Thommes, Michael D Decker, Ayman Chit
Background: To examine whether a high-dose inactivated influenza vaccine was more efficacious in preventing hospitalizations than a standard-dose vaccine in the Veterans Health Administration (VHA) senior population. Methods: This study estimated the relative vaccine effectiveness (rVE) of high-dose versus standard-dose using a retrospective cohort of VHA patients 65 years of age or older in the 2015-16 influenza season. To adjust for measured confounders, we matched each high-dose recipient with up to four standard-dose recipients vaccinated at the same location within a two-week period and having two or more pre-existing medical co-morbidities...
February 14, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29452371/a-bidirectional-association-between-cognitive-ability-in-young-adulthood-and-epilepsy-a-population-based-cohort-study
#5
Merete Osler, Erik L Mortensen, Kaare Christensen, Gunhild T Christensen
Aim: To investigate the bidirectional association between cognitive ability in young adulthood and epilepsy. Methods: This cohort study included 1 159 076 men enrolled in the mandatory conscription board examination from the Danish Conscription Database (DCD; 658 465 men examined 1957-84), the Danish Defence Personnel Organization Database (DPOD; 216 509 men examined 1987-2005) and the Danish Conscription Registry (DCR; 284 102 men examined 2006-15). A supplementary analysis included 14 814 female volunteers...
February 14, 2018: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29452366/prevalence-and-incidence-of-anal-and-cervical-high-risk-human-papillomavirus-hpv-types-covered-by-current-hpv-vaccines-among-hiv-infected-women-in-the-study-to-understand-the-natural-history-of-hiv-aids-in-the-era-of-effective-therapy-the-sun-study
#6
Erna Milunka Kojic, Lois Conley, Tim Bush, Susan Cu-Uvin, Elizabeth R Unger, Keith Henry, John Hammer, Gerome Escota, Teresa M Darragh, Joel M Palefsky, John T Brooks, Pragna Patel
Background: Nonavalent (9v) human papilloma virus vaccine targets high-risk (HR)-HPV types 16, 18, 31, 33, 45, 52, 58, and low-risk 6, 11. We examined prevalence, incidence, and clearance of anal and cervical HR-HPV in HIV-infected women. Methods: From 2004-2006, the SUN Study enrolled 167 women from four US cities. Anal and cervical specimens were collected annually for cytology and identification of 37 HPV types; 14 HR include: 9v 16, 18, 31, 33, 45, 52, 58; non-9v 35, 39, 51, 56, 59, 66, 68...
February 14, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29452362/reported-theory-use-in-walking-interventions-a-literature-review-and-research-agenda
#7
Mohammad Abdul Kadir, Sharyn Rundle-Thiele
There is mixed evidence with some suggesting walking can be increased up to the recommended level through interventions based on behaviour change models and others showing partial or no effects [Arbour and Ginis (A randomised controlled trial of the effects of implementation intentions on women's walking behaviour. Psychol Health, 2009;24:49-65); Merom et al. (Can a motivational intervention overcome an unsupportive environment for walking-findings from the Step-by-Step Study. Ann Behav Med 2009;38:137-46); Ornes and Ransdell (A pilot study examining exercise self-efficacy as a mediator for walking behavior in college-age women...
February 14, 2018: Health Promotion International
https://www.readbyqxmd.com/read/29452356/baseline-anticholinergic-burden-from-medications-predicts-incident-fatal-and-non-fatal-stroke-in-the-epic-norfolk-general-population
#8
David T Gamble, Allan B Clark, Robert N Luben, Nicholas J Wareham, Kay-Tee Khaw, Phyo K Myint
Background: Stroke is primarily a disease of older age, with a substantial impact on global mortality and morbidity. Medications with anticholinergic effects are widely used, but no studies have been conducted to examine the relationship between anticholinergic burden (ACB) and stroke in a general population. Method: The sample was drawn from the EPIC-Norfolk cohort. Baseline assessments were carried out during 1993-97 and participants were followed up until March 2016...
February 14, 2018: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29452335/change-in-cardiometabolic-risk-among-blacks-whites-and-hispanics-findings-from-the-health-and-retirement-study
#9
Uchechi A Mitchell, Jennifer A Ailshire, Eileen M Crimmins
Background: Blacks experience greater multi-system physiological dysregulation, or cumulative biological risk, which is associated with poor cardiometabolic health and mortality. In this study, we assess race differences in change in risk over four years among older whites, blacks and Hispanics. Method: We examined race differences in 4-year change in individual biomarkers and a cumulative measure of risk-cardiometabolic risk (CMR)-using data for each respondent from two waves of the Health and Retirement Study's biomarker assessment (n=5,512)...
February 14, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29452330/atypical-teratoid-rhabdoid-tumor-after-in-vitro-fertilization-illustrative-case-report-and-systematic-literature-review
#10
REVIEW
Adomas Bunevicius, Algimantas Matukevicius, Vytenis Deltuva, Inga Gudinaviciene, Darius Pranys, Arimantas Tamsauskas
OBJECTIVE: In vitro fertilization (IVF) is increasingly used for treatment of infertile couples worldwide. The association between IVF and cancer risk in offsprings is conflicting. We present a case of atypical teratoid/rhabdoid tumor (AT/RT) in a girl conceived by IVF and present results of systematic review of literature of primary intracranial neoplasms diagnosed in children conceived by IVF. METHODS: A systematic review of literature was conducted on April 12, 2017 to identify previously published reports of intracranial brain tumors in patients conceived after IVF...
February 13, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29452329/a-frontal-sinus-osteoma-accompanied-by-an-intracranial-mucocele-and-local-hyperostosis-frontalis-interna
#11
Yang Yang, Liang Wang, Zhen Wu
Frontal sinus osteoma accompanied by intracranial mucocele and local hyperostosis frontalis interna has never been reported. A 47-year-old woman presented with a 3-month history of intermittent headache. Physical examination revealed no neurological abnormality. Contrasted MRI showed a frontal heterogeneously enhanced lesion with adjacent non-enhanced cyst. Computed tomography showed a bone-density mass, which was accompanied by local hyperostosis frontalis interna, filled the left frontal sinus and extended intracranially...
February 13, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29452326/awake-microvascular-decompression-for-trigeminal-neuralgia-concept-and-initial-results
#12
Saleem I Abdulrauf, Jorge F Urquiaga, Ritesh Patel, J Andrew Albers, Varun B Sampat, Meghan Baumer, Eric Marvin, Matthew Pierson, Raquel Kragel, Jodi Walsh
OBJECTIVE: The option of performing MVD under awake anesthesia protocol ("awake" MVD) was examined in this initial series to assess whether intraoperative pain evaluation can identify and mitigate insufficient decompression of the trigeminal nerve, improving surgical outcomes. Additionally, "awake" MVD could expand procedure indications for those with comorbidities that would prohibit general endotracheal anesthesia (GEA). METHODS: An IRB-approved prospective study of 10 consecutive adults who underwent MVD for TN was conducted...
February 13, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29452321/hypoplastic-straight-sinus-with-persistent-falcine-sinus-in-an-adult-with-sinus-pericranii
#13
Lukas Andereggen, Rajeev K Verma
Open MRI of a 45-year-old man with panic disorder showed a sinus pericranii (SP). Examination of the scalp revealed a discolored scalp mass and MR venography displayed a hypoplastic straight sinus with persistent falcine sinus. SP is a venous anomaly consisting of a transosseous vascular channel connecting an intracranial sinus with subgaleal veins. High venous pressure in the late embryonic stage, as with a hypoplastic straight sinus, has been hypothesized to predispose affected individuals to develop other venous anomalies, i...
February 13, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29452312/effects-of-higher-versus-lower-threat-contexts-on-pain-related-visual-attention-biases-an-eye-tracking-study-of-chronic-pain
#14
Todd Jackson, Lin Su, Yang Wang
In this research, we examined effects of higher versus lower threat contexts on attention biases in more and less pain-fearful chronic pain subgroups via eye-tracking methodology. Within a mixed chronic pain sample (69 women, 29 men), biases in orienting and maintenance of visual attention were assessed during the standardized image pair presentation phase (2000ms) of a modified visual dot probe task featuring painful-neutral (P-N) image pairs (lower threat context) and a parallel task in which these P-N pairs cued potential pain (higher threat context)...
February 13, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29452307/impact-of-metabolic-syndrome-on-clinical-severity-and-long-term-prognosis-in-patients-with-myocardial-infarction-with-st-segment-elevation
#15
Lovic, Dragan B Djordjevic, Ivan S Tasic, Ivana P Nedeljkovic
AIMS: The aim of this study is to evaluate the impact of metabolic syndrome (MetS) on clinical severity and long term prognosis in patients with myocardial infarction with ST segment elevation (STEMI). METHODS: We examined 507 patients with STEMI who were admitted for primary percutaneous coronary intervention classified according to the presence of MetS using American Heart Association and the National Heart, Lung and Blood Institute definition. After applying these criteria, the patients were categorized in patients with MetS and without MetS...
February 13, 2018: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/29452280/sticholysin-ii-mediated-cytotoxicity-involves-the-activation-of-regulated-intracellular-responses-that-anticipates-cell-death
#16
Carmen Soto, Gretchen Bergado, Rancés Blanco, Tania Griñán, Hermis Rodríguez, Uris Ros, Fabiola Pazos, María Eliana Lanio, Ana María Hernández, Carlos Álvarez
Sticholysin II (StII) is a pore-forming toxin of biomedical interest that belongs to the actinoporin protein family. Sticholysins are currently under examination as an active immunomodulating component of a vaccinal platform against tumoral cells and as a key element of a nucleic acids delivery system to cell cytosol. These proteins form pores in the plasma membrane leading to ion imbalance and cell lysis. However, the intracellular mechanisms triggered by actinoporins upon binding to membranes and its consequences for cell death are barely understood...
February 13, 2018: Biochimie
https://www.readbyqxmd.com/read/29452265/characterizing-the-modulation-of-resting-state-fmri-metrics-by-baseline-physiology
#17
Powell P W Chu, Ali M Golestani, Jonathan B Kwinta, Yasha B Khatamian, J Jean Chen
The blood-oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) signal is commonly used to assess functional connectivity across brain regions, particularly in the resting state (rs-fMRI). However, the BOLD fMRI signal is not merely a representation of neural activity, but a combination of neural activity and vascular response. These aspects of the BOLD signal are easily influenced by systemic physiology, potentially biasing BOLD-based functional connectivity measurements. In this work, we focus on the following physiological modulators of the BOLD signal: cerebral blood flow (CBF), venous blood oxygenation, and cerebrovascular reactivity (CVR)...
February 13, 2018: NeuroImage
https://www.readbyqxmd.com/read/29452264/antagonists-to-trpv1-asics-and-p2x-have-a-potential-role-to-prevent-the-triggering-of-regional-bone-metabolic-disorder-and-pain-like-behavior-in-tail-suspended-mice
#18
Megumi Hanaka, Kousuke Iba, Takayuki Dohke, Kumiko Kanaya, Shunichiro Okazaki, Toshihiko Yamashita
Our recent studies demonstrated that regional bone loss in the unloaded hind limbs of tail-suspended mice triggered pain-like behaviors due to the acidic environment in the bone induced by osteoclast activation. The aims of the present study were to examine whether TRPV1, ASIC and P2X (known as nociceptors) are expressed in bone, and whether the antagonists to those receptors affect the expression of osteoblast and osteoclast regulators, and prevent the triggering of not only pain-like behaviors but also high bone turnover conditions in tail-suspension model mice...
February 14, 2018: Bone
https://www.readbyqxmd.com/read/29452233/role-of-adipose-tissue-derived-stem-cells-differentiated-into-insulin-producing-cells-in-the-treatment-of-type-i-diabetes-mellitus
#19
Mona G Amer, Azza S Embaby, Rehab A Karam, Marwa G Amer
Generation of new β cells is an important approach in the treatment of type 1 diabetes mellitus (type 1 DM). Adipose tissue-derived stem cells (ADSCs) might be one of the best sources for cell replacement therapy for diabetes. Therefore, this work aimed to test the possible role of transplanted insulin-producing cells (IPCs) differentiated from ADSCs in treatment of streptozotocin (STZ) induced type I DM in rats. Type 1 DM was induced by single intra peritoneal injection with STZ (50 mg/kg BW). Half of the diabetic rats were left without treatment and the other half were injected with differentiated IPCs directly into the pancreas...
February 13, 2018: Gene
https://www.readbyqxmd.com/read/29452227/age-and-experience-dependent-changes-in-egr-1-expression-during-the-ontogeny-of-the-context-preexposure-facilitation-effect-cpfe
#20
P A Robinson-Drummer, T Chakraborty, N A Heroux, J B Rosen, M E Stanton
The context preexposure facilitation effect (CPFE) is a variant of contextual fear conditioning in which acquisition of the contextual representation and association of the retrieved contextual memory with an immediate foots-hock are separated by 24hrs. During the CPFE, learning- related expression patterns of the early growth response -1 gene (Egr-1) vary based on training phase and brain sub-region in adult and adolescent rats (Asok, Schreiber, Jablonski, Rosen, & Stanton, 2013; Shreiber et al., 2014; Chakraborty, Asok, Stanton, & Rosen, 2016)...
February 13, 2018: Neurobiology of Learning and Memory
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