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https://www.readbyqxmd.com/read/29351901/xiap-regulation-by-mnk-links-mapk-and-nf%C3%AE%C2%BAb-signaling-to-determine-an-aggressive-breast-cancer-phenotype
#1
Myron K Evans, Michael C Brown, Joseph Geradts, Xuhui Bao, Timothy J Robinson, Mohit Kumar Jolly, Peter Vermeulen, Gregory M Palmer, Matthias Gromeier, Herbert Levine, Michael A Morse, Steven Van Laere, Gayathri R Devi
Hyperactivation of the NFκB pathway is a distinct feature of inflammatory breast cancer (IBC), a highly proliferative and lethal disease. Gene expression studies in IBC patient tissue have linked epidermal growth factor receptor (EGFR/HER2)-mediated MAPK signaling to NFκB hyperactivity, but the mechanism(s) by which this occurs remain unclear. Here, we report that the X-linked inhibitor of apoptosis protein (XIAP) plays a central role in linking these two pathways. XIAP overexpression correlated with poor prognoses in breast cancer patients and was frequently observed in untreated IBC patient primary tumors...
January 19, 2018: Cancer Research
https://www.readbyqxmd.com/read/29351853/cardiac-biomarkers-as-sensitive-tools-to-evaluate-the-impact-of-xenobiotics-on-amphibians-the-effects-of-anionic-surfactant-linear-alkylbenzene-sulfonate-las
#2
Monica Jones-Costa, Lilian Franco-Belussi, Felipe Augusto Pinto Vidal, Nathália Penteado Gongora, Luciano Mendes Castanho, Cleoni Dos Santos Carvalho, Elaine Cristina Mathias Silva-Zacarin, Fabio Camargo Abdalla, Iolanda Cristina Silveira Duarte, Classius De Oliveira, Cristiane Ronchi de Oliveira, Raquel Fernanda Salla
Amphibian populations have been experiencing a drastic decline worldwide. Aquatic contaminants are among the main factors responsible for this decline, especially in the aquatic environment. The linear alkylbenzene sulfonate (LAS) is of particular concern, since it represents 84% of the anionic surfactants' trade. In Brazil, the maximal LAS concentration allowed in fresh waters is 0.5mgL-1, but its potential harmful effects in amphibians remain unknown. Therefore, this study aimed to analyze the effects of a sublethal concentration of LAS (0...
January 16, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29345929/antihypertensive-effects-molecular-docking-study-and-isothermal-titration-calorimetry-assay-of-the-angiotensin-i-converting-enzyme-inhibitory-peptides-from-chlorella-vulgaris
#3
Jingli Xie, Xujun Chen, Junjie Wu, Yanyan Zhang, Yan Zhou, Lujia Zhang, Yajie Tang, Dong-Zhi Wei
The aim of this work is to explore angiotensin I-converting enzyme (ACE) inhibitory peptides from Chlorella vulgaris (C. vulgaris) and discover the inhibitory mechanism of the peptides. After C. vulgaris proteins were gastrointestinal digested in silico, several ACE inhibitory peptides with C-terminal tryptophan were screened. Among them, two novel non-competitive ACE inhibitors, Thr-Thr-Trp (TTW) and Val-His-Trp (VHW), exhibited the highest inhibitory activity indicated by IC50 values, 0.61 ± 0.12 and 0.91 ± 0...
January 18, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29345170/cemented-total-hip-replacement-in-patients-under-55-years
#4
Manish Kiran, Linda R Johnston, Sankar Sripada, Gordon G Mcleod, Arpit C Jariwala
Background and purpose - About 86,000 total hip replacements (THR) have been registered in patients under 55 years in the National Joint Registry of England and Wales (NJR). The use of uncemented implants has increased, despite their outcomes not having been proven to be significantly better than cemented implants in this registry. We determined the implant survivorship and functional outcomes of cemented THR in patients under 55 years at a minimum follow-up of 22 years. Patients and methods - 104 hips in 100 patients were included in this prospective study...
January 18, 2018: Acta Orthopaedica
https://www.readbyqxmd.com/read/29338713/lncrna-dancr-involved-osteolysis-after-total-hip-arthroplasty-by-regulating-foxo1-expression-to-inhibit-osteoblast-differentiation
#5
Zhenyu Tang, Zongming Gong, Xiaoliang Sun
BACKGROUND: Aseptic loosening of artificial hip joint is a major complication affecting the long-term use of the artificial hip joint, and is the main cause of joint replacement failure. However, the mechanism of aseptic loosening of THR has not yet cleared. The aim of this study was to investigate the underlying mechanism of DANCR in osteoblast differentiation (OD). METHODS: We detected the expressions of DANCR and FOXO1 in clinical samples and mesenchymal stem cells (MSCs) by qRT-PCR and western blotting...
January 16, 2018: Journal of Biomedical Science
https://www.readbyqxmd.com/read/29336679/arcobacter-butzleri-ciprofloxacin-resistance-point-mutations-in-dna-gyrase-a-and-role-on-fitness-cost
#6
Susana Ferreira, Daniela R Correia, Mónica Oleastro, Fernanda C Domingues
Arcobacter butzleri is a widely distributed emerging pathogen resistant to various classes of antimicrobial agents, namely fluoroquinolones. A. butzleri resistance to fluoroquinolones is conferred by point mutations at the antibiotic target. The aim of this study was to evaluate mutations at gyrA associated with ciprofloxacin resistance and evaluate whether acquisition of resistance impacts on fitness and stress tolerance of A. butzleri. A. butzleri ciprofloxacin mutants were generated by laboratory induction...
January 16, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29324716/the-effects-of-a-macromolecular-charring-agent-with-gas-phase-and-condense-phase-synergistic-flame-retardant-capability-on-the-properties-of-pp-ifr-composites
#7
Hongda Chen, Jihui Wang, Aiqing Ni, Anxin Ding, Xia Han, Ziheng Sun
In order to improve the efficiency of intumescent flame retardants (IFRs), a novel macromolecular charring agent named poly(ethanediamine-1,3,5-triazine-p-4-amino-2,2,6,6-tetramethylpiperidine) (PETAT) with gas phase and condense phase synergistic flame-retardant capability was synthesized and subsequently dispersed into polypropylene (PP) in combination with ammonium polyphosphate (APP) via a melt blending method. The chemical structure of PETAT was investigated by Fourier transform infrared spectroscopy (FTIR), and ¹H nuclear magnetic resonance (NMR) spectroscopy...
January 11, 2018: Materials
https://www.readbyqxmd.com/read/29324354/an-in-depth-prognostic-analysis-of-baseline-blood-lipids-in-predicting-postoperative-colorectal-cancer-mortality-the-fiesta-study
#8
Feng Peng, Dan Hu, Xiandong Lin, Gang Chen, Binying Liang, Ying Chen, Chao Li, Hejun Zhang, Yan Xia, Jinxiu Lin, Xiongwei Zheng, Wenquan Niu
BACKGROUND: Dyslipidaemia is key to colorectal carcinogenesis, and the prediction of baseline triglycerides (TG), total cholesterol (TC), high- and low-density lipoprotein cholesterol (HDLC and LDLC) for postsurgical colorectal cancer mortality has not been researched. OBJECTIVES: We attempted to re-analyse the FIESTA database to assess the prognostic value of three informative lipid derivatives - AI (atherogenic index: (TC - HDLC)/HDLC), THR (TG/HDLC) and LHR (LDLC/HDLC) in predicting colorectal cancer mortality...
January 8, 2018: Cancer Epidemiology
https://www.readbyqxmd.com/read/29321571/thrombin-fe3o4-nanoparticles-for-use-as-a-hemostatic-agent-in-internal-bleeding
#9
Emiliya M Shabanova, Andrey S Drozdov, Anna F Fakhardo, Ivan P Dudanov, Marina S Kovalchuk, Vladimir V Vinogradov
Bleeding remains one of the main causes of premature mortality at present, with internal bleeding being the most dangerous case. In this paper, magnetic hemostatic nanoparticles are shown for the first time to assist in minimally invasive treatment of internal bleeding, implying the introduction directly into the circulatory system followed by localization in the bleeding zone due to the application of an external magnetic field. Nanoparticles were produced by entrapping human thrombin (THR) into a sol-gel derived magnetite matrix followed by grinding to sizes below 200 nm and subsequent colloidization...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29321381/association-between-genetic-polymorphism-and-levothyroxine-bioavailability-in-hypothyroid-patients
#10
Merve Arici, Ezgi Oztas, Fatih Yanar, Nihat Aksakal, Beyza Ozcinar, Gul Ozhan
Thyroid hormones play a vital role in the human body for growth and differentiation, regulation of energy metabolism, and physiological function. Hypothyroidism is a common endocrine disorder, which generally results from diminished normal circulating concentrations of serum thyroxine (fT4) and triiodothyronine (fT3). The primary choice in hypothyroidism treatment is oral administration of levothyroxine (L-T4), a synthetic T4 hormone, as approximately 100-125 μg/day. Generally, dose adjustment is made by trial and error approach...
January 11, 2018: Endocrine Journal
https://www.readbyqxmd.com/read/29318080/race-and-rehabilitation-destination-after-elective-total-hip-arthroplasty-analysis-of-a-large-regional-data-set
#11
Ernest R Vina, Michael J Kallan, Aliya Collier, Charles L Nelson, Said A Ibrahim
Background: Three-quarters of patients who undergo total hip replacement (THR) receive postsurgical rehabilitation care in an inpatient rehabilitation facility (IRF), a skilled nursing facility (SNF), or through a home health agency. The objectives of this study are to examine racial differences where THR recipients receive postsurgical rehabilitation care and determine whether discharge destination is associated with hospital readmission. Methods: Using the Pennsylvania Health Care Cost Containment Council database, we selected African American (AA) or white adults who underwent THR surgery (n = 68,016)...
December 2017: Geriatric Orthopaedic Surgery & Rehabilitation
https://www.readbyqxmd.com/read/29317643/multiple-mutations-and-overexpression-of-the-mdae7-carboxylesterase-gene-associated-with-male-linked-malathion-resistance-in-housefly-musca-domestica-diptera-muscidae
#12
Yi Zhang, Jing Li, Zhuo Ma, Chao Shan, Xiwu Gao
Two unique housefly strains, MSS and N-MRS, were selected and used to clarify mechanisms of sex-associated malathion resistance in the housefly, Musca domestica. Compared with the lab-susceptible CSS strain, susceptible females and resistant males were observed in the malathion-susceptible MSS strain, while the malathion-resistant near-isogenic line, N-MRS, achieved similar resistance level between genders. Significant synergistic effect of the esterase-inhibitor DEF on resistant houseflies pointed to the important involvement of esterase in this specific malathion resistance...
January 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29317228/functions-and-dysfunctions-of-ca2-calmodulin-dependent-protein-kinase-phosphatase-camkp-ppm1f-and-camkp-n-ppm1e
#13
REVIEW
Atsuhiko Ishida, Noriyuki Sueyoshi, Isamu Kameshita
Intracellular signal transduction is built on the basis of the subtle balance between phosphorylation and dephosphorylation. Ca2+/calmodulin-dependent protein kinase phosphatase (CaMKP/PPM1F/POPX2) and CaMKP-N (PPM1E/POPX1) are Ser/Thr phosphatases that belong to the PPM (protein phosphatase, Mg2+/Mn2+-dependent) family. The former was discovered in rat brain as a novel protein phosphatase regulating Ca2+/calmodulin-dependent protein kinases (CaMKs), whereas the latter was first identified in human cDNA databases using the rat CaMKP sequence...
January 6, 2018: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29311244/coxiella-burnetii-inhibits-neutrophil-apoptosis-by-exploiting-survival-pathways-and-anti-apoptotic-protein-mcl-1
#14
Rama Cherla, Yan Zhang, Lindsey Ledbetter, Guoquan Zhang
Our previous study demonstrated that neutrophils play an important role in host defense against Coxiella burnetii infection in mice. In this study, C. burnetii avirulent Nine Mile phase II (NMII) was used to examine if C. burnetii can modulate mouse bone marrow-derived neutrophil apoptosis. The results indicated that NMII can inhibit neutrophil apoptosis. Western blotting demonstrated that caspase-3 cleavage was decreased, while phosphorylated mitogen-activated protein kinase (MAPK) p38 and extracellular signal-regulated kinase 1 (Erk1) were increased in NMII-infected neutrophils...
January 8, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29310144/kolaviron-and-garcinia-kola-seed-extract-protect-against-ischaemia-reperfusion-injury-on-isolated-rat-heart
#15
Ademola Adetokunbo Oyagbemi, Dirk Bester, Johan Esterhuyse, Ebenezer Olatunde Farombi
BACKGROUND: The incidence of cardiovascular diseases and its associated complications have increased greatly in the past three decades. The purpose of this study was to evaluate the acute cardioprotective effects of Garcinia kola (GK) seed extract and Kolaviron (KV) and determine mechanisms of action involving RISK signalling pathways. METHODS: Male Wistar rats were used in this study. Hearts were excised and mounted on the Langendorff perfusion system. The control, group 1 was perfused with dimethyl sulfoxide (DMSO), group II with KV and group III with GK respectively...
January 8, 2018: Drug Research
https://www.readbyqxmd.com/read/29309873/mechanistic-insights-into-the-urea-induced-denaturation-of-kinase-domain-of-human-integrin-linked-kinase
#16
Sunayana Begum Syed, Faez Iqbal Khan, Sabab Hasan Khan, Saurabha Srivastava, Gulam Mustafa Hasan, Kevin A Lobb, Asimul Islam, Faizan Ahmad, Md Imtaiyaz Hassan
Integrin-linked kinase (ILK), a ubiquitously expressed intracellular Ser/Thr protein kinase, plays a major role in the oncogenesis and tumour progression. The conformational stability and unfolding of kinase domain of ILK (ILK193-446) was examined in the presence of increasing concentrations of urea. The stability parameters of the urea-induced denaturation were measured by monitoring changes in [θ]222 (mean residue ellipticity at 222nm), difference absorption coefficient at 292nm (Δε292) and intrinsic fluorescence emission intensity at pH7...
January 5, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29305429/back-to-the-future-new-target-validated-rab-antibodies-for-evaluating-lrrk2-signalling-in-cell-biology-and-parkinson-s-disease
#17
Patrick A Eyers
The addition of phosphate groups to substrates allows protein kinases to regulate a myriad of biological processes, and contextual analysis of protein-bound phosphate is important for understanding how kinases contribute to physiology and disease. Leucine-rich repeat kinase 2 (LRRK2) is a Ser/Thr kinase linked to familial and sporadic cases of Parkinson's disease (PD). Recent work established that multiple Rab GTPases are physiological substrates of LRRK2, with Rab10 in particular emerging as a human substrate whose site-specific phosphorylation mirrors hyperactive LRRK2 lesions associated with PD...
January 5, 2018: Biochemical Journal
https://www.readbyqxmd.com/read/29301510/exogenous-short-term-silicon-application-regulates-macro-nutrients-endogenous-phytohormones-and-protein-expression-in-oryza-sativa-l
#18
Soo-Won Jang, Yoonha Kim, Abdul Latif Khan, Chae-In Na, In-Jung Lee
BACKGROUND: Silicon (Si) has been known to regulate plant growth; however, the underlying mechanisms of short-term exogenous Si application on the regulation of calcium (Ca) and nitrogen (N), endogenous phytohormones, and expression of essential proteins have been little understood. RESULTS: Exogenous Si application significantly increased Si content as compared to the control. Among Si treatments, 1.0 mM Si application showed increased phosphorus content as compared to other Si treatments (0...
January 4, 2018: BMC Plant Biology
https://www.readbyqxmd.com/read/29299988/an-overview-of-discovery-of-thiazole-containing-heterocycles-as-potent-gsk-3%C3%AE-inhibitors
#19
Deepika Sharma, Anjleena Malhotra, Ranju Bansal
Glycogen synthase kinase-3 (GSK-3) is a multifunctional serine/threonine (ser/thr) kinase that was originally identified as a regulator of glycogen metabolism and coupled with insulin signaling. Due to multifunctionality of this enzyme, it is found to play an important role in the onset and progression of various human diseases. Thiazole nucleus has received special attention by medicinal chemists because of its wide therapeutic potential. The objective of this review is to cover all the aspects of GSK-3β enzyme including its clinical implications, types of inhibitors with special reference to thiazole as GSK-3β inhibitor...
January 4, 2018: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/29299650/can-patient-reported-outcomes-predict-re-operations-after-total-hip-replacement
#20
Ted Eneqvist, Szilárd Nemes, Erik Bülow, Maziar Mohaddes, Ola Rolfson
PURPOSE: We investigated if patient-reported outcomes (PROMs) one year after total hip replacement (THR) can predict the risk of re-operation using data from the Swedish Hip Arthroplasty Register. METHODS: A total of 75,899 patients with THR due to osteoarthritis operated in 2002-2014 were included. We used Kaplan-Meier and Cox regression to investigate the relationship between one-year post-operative PROMs and risk of re-operation (all types of further hip surgery)...
January 3, 2018: International Orthopaedics
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