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https://www.readbyqxmd.com/read/28222212/excellent-mid-term-results-of-a-new-polished-tapered-modular-cemented-stem-a-study-of-113-hip-replacements-with-minimum-5-year-follow-up
#1
Jens Vanbiervliet, Jan F A Somers
BACKGROUND: This prospective cohort study reports the medium-term clinical and radiographic results of 113 hips treated with a hybrid total hip replacement (THR) with a new cemented tapered cobalt-chrome (Co-Cr) stem with a titanium (Ti) modular neck (ProfemurXm®). METHOD: Between October 2008 and December 2010 we performed 115 consecutive hybrid THR with the ProfemurXm® in 105 patients. RESULTS: Survivorship of the implant (stem and modular neck) at a mean of 6...
February 18, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/28219718/a-novel-regulatory-role-of-rgs4-in-stat5b-activation-neurite-outgrowth-and-neuronal-differentiation
#2
Paschalina Pallaki, Eirini-Maria Georganta, Ioannis Serafimidis, Maria-Pagona Papakonstantinou, Vassilis Papanikolaou, Sofia Koutloglou, Elsa Papadimitriou, Adamantia Agalou, Aggeliki Tserga, Alexandra Simeonof, Dimitra Thomaidou, Maria Gaitanou, Zafiroula Georgoussi
The Regulator of G protein Signalling 4 (RGS4) is a multitask protein that interacts with and negatively modulates opioid receptor signalling. Previously, we showed that the δ-opioid receptor (δ-OR) forms a multiprotein signalling complex consisting of Gi/Go proteins and the Signal Transducer and Activator of Transcription 5B (STAT5B) that leads to neuronal differentiation and neurite outgrowth upon δ-ΟR activation. Here, we investigated whether RGS4 could participate in signalling pathways to regulate neurotropic events...
February 17, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28216439/role-of-thyroid-hormone-in-hepatic-gene-regulation-chromatin-remodeling-and-autophagy
#3
Brijesh Kumar Singh, Rohit Anthony Sinha, Kenji Ohba, Paul Michael Yen
Thyroid hormone (TH) actions on development and metabolism have been studied ever since the discovery of thyroxine almost a century ago. Initial studies focused on the physiological and biochemical actions of TH. Later, the cloning of the thyroid hormone receptor (THR) isoforms and the development of techniques enabled the study of TH regulation of complex cellular processes (such as gene transcription). Recently we found that TH activates secondary transcription factors such as FOXO1, to amplify gene transcription; and also is a potent inducer of autophagy that was critical for fatty acid β-oxidation in the liver...
February 16, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28212617/surfactant-protein-d-sp-d-gene-polymorphisms-and-serum-level-as-predictors-of-susceptibility-and-prognosis-of-acute-kidney-injury-in-the-chinese-population
#4
Jiao Liu, Guang Li, Lianghai Li, Zhiyong Liu, Qingshan Zhou, Guirong Wang, Dechang Chen
BACKGROUND: Injury to the kidney epithelial barrier is a characteristic feature of acute kidney injury (AKI). Serum surfactant protein-D (SP-D), a known biomarker of damaged alveolar epithelium, is also secreted by renal tubular epithelial cells. Therefore, the aim of this study was to examine the possible association of SP-D with AKI susceptibility and prognosis. METHODS: In this study, 159 AKI patients and 120 healthy individuals were included. SP-D polymorphisms Thr11Met and Thr160Ala, AKI patient serum SP-D levels at days 1, 3 and 7 and urine KIM-1 levels in both AKI patients and controls were examined...
February 17, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28209983/generation-and-quantitative-proteomics-analysis-of-ck2%C3%AE-%C3%AE-cells
#5
Christian Borgo, Cinzia Franchin, Stefano Scalco, Valentina Bosello-Travain, Arianna Donella-Deana, Giorgio Arrigoni, Mauro Salvi, Lorenzo A Pinna
CK2 is a ubiquitous, constitutively active, highly pleiotropic, acidophilic Ser/Thr protein kinase whose holoenzyme is composed of two catalytic (α and/or α') subunits and a dimer of a non-catalytic β subunit. Abnormally high CK2 level/activity is often associated with malignancy and a variety of cancer cells have been shown to rely on it to escape apoptosis. To gain information about the actual "druggability" of CK2 and to dissect CK2 dependent cellular processes that are instrumental to the establishment and progression of neoplasia we have exploited the CRISPR/Cas9 genome editing technology to generate viable clones of C2C12 myoblasts devoid of either both the CK2 catalytic subunits or its regulatory β-subunit...
February 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28203298/prolyl-isomerase-pin1-and-neurotrophins-a-loop-that-may-determine-the-fate-of-cells-in-cancer-and-neurodegeneration
#6
REVIEW
Francesco Angelucci, Jakub Hort
Increased survival, differentiation, and apoptotic death are common mechanisms relevant for both cancer and neurodegenerative diseases. Although these disorders are characterized by different manifestations, it appears that a common mechanism may be present which directs the fate of a cell to either degeneration or proliferation. There are two classes of proteins that have been extensively investigated in these diseases but their possible interaction during signal transduction has not been studied. Prolyl isomerase Pin1 is an enzyme which translates Ser/Thr-Pro phosphorylation into conformational changes able to modify the activities of its substrates...
January 2017: Therapeutic Advances in Medical Oncology
https://www.readbyqxmd.com/read/28195154/zinc-finger-protein-zpr9-functions-as-an-activator-of-ampk-related-serine-threonine-kinase-mpk38-melk-involved-in-ask1-tgf-%C3%AE-p53-signaling-pathways
#7
Hyun-A Seong, Ravi Manoharan, Hyunjung Ha
Murine protein serine-threonine kinase 38 (MPK38), an AMP-activated protein kinase (AMPK)-related kinase, has been implicated in the induction of apoptosis signal-regulating kinase 1 (ASK1)-, transforming growth factor-β (TGF-β)-, and p53-mediated activity involved in metabolic homeostasis. Here, zinc finger protein ZPR9 was found to be an activator of MPK38. The association of MPK38 and ZPR9 was mediated by cysteine residues present in each of these two proteins, Cys(269) and Cys(286) of MPK38 and Cys(305) and Cys(308) of ZPR9...
February 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28194973/implications-for-the-light-driven-chloride-ion-transport-mechanism-of-nonlabens-marinus-rhodopsin-3-by-its-photochemical-characteristics
#8
Takashi Tsukamoto, Susumu Yoshizawa, Takashi Kikukawa, Makoto Demura, Yuki Sudo
Several new retinal-based photoreceptor proteins that act as light-driven electrogenic halide ion pumps have recently been discovered. Some of them, called "NTQ" rhodopsins, contain a conserved Asn-Thr-Gln motif in the 3(rd) or C-helix. In this study, we investigated the photochemical characteristics of a NTQ rhodopsin, Nonlabens marinus rhodopsin 3 (NM-R3), which was discovered in the N. marinus S1-08(T) strain, using static and time-resolved spectroscopic techniques. We demonstrate that NM-R3 binds a Cl(-) in the vicinity of the retinal chromophore accompanied by a spectral blue shift from 568 nm in the absence of Cl(-) to 534 nm in the presence of Cl(-)...
February 14, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28194851/inversion-of-the-side-chain-stereochemistry-of-indvidual-thr-or-ile-residues-in-a-protein-molecule-impact-on-the-folding-stability-and-structure-of-the-shk-toxin
#9
Bobo Dang, Rong Shen, Tomoya Kubota, Kalyaneswar Mandal, Francisco Bezanilla, Benoit Roux, Stephen B H Kent
ShK toxin is a cysteine-rich 35-residue protein ion-channel ligand isolated from the sea anemone Stichodactyla helianthus. In this work, we studied the effect of inverting the side chain stereochemistry of individual Thr or Ile residues on the properties of the ShK protein. Molecular dynamics simulations were used to calculate the free energy cost of inverting the side-chain stereochemistry of individual Thr or Ile residues. Guided by the computational results, we used chemical protein synthesis to prepare three ShK polypeptide chain analogues, each containing either an allo-Thr or an allo-Ile residue...
February 14, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28194414/acetabular-fractures-in-the-elderly-midterm-outcomes-of-column-stabilisation-and-primary-arthroplasty
#10
A Ortega-Briones, S Smith, M Rickman
Background. Interest in arthroplasty techniques for periarticular or intra-articular fractures in the elderly/osteoporotic patient continues to rise, including for geriatric acetabular fractures. In line with this, many acetabular fracture surgeons are now undertaking acute total hip arthroplasty in elderly/osteoporotic patients. Little is known however of the outcomes of this procedure, beyond the first year after surgery. Questions/Purposes. We determined the clinical outcomes of a series of elderly osteoporotic patients (mean age at surgery 77...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28193498/a-prospective-cohort-study-examining-medical-and-social-factors-associated-with-engagement-in-life-activities-following-total-hip-replacement
#11
Crystal MacKay, Fiona Webster, Viji Venkataramanan, Jessica Bytautas, Anthony V Perruccio, Rosalind Wong, Lisa Carlesso, Aileen M Davis
OBJECTIVES: Studies show limited improvement in the frequency of engaging in life activities after joint replacement. However, there is a paucity of research that has examined factors, including other life events, which influence engagement following total hip replacement (THR). This research sought to identify factors associated with engaging in life activities following THR. METHODS: A prospective cohort study was conducted with 376 people who had a THR for osteoarthritis...
February 10, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28193369/-expressed-emotions-burden-and-family-functioning-in-schizophrenic-and-bipolar-i-patients-of-a-multimodal-intervention-program-prisma
#12
Alexandra Ramírez, Juan David Palacio, Cristian Vargas, Ana María Díaz-Zuluaga, Kelly Duica, Yuli Agudelo Berruecos, Sigifredo Ospina, Carlos López-Jaramillo
INTRODUCTION: Bipolar disorder and schizophrenia are causes of major suffering in patients. Nevertheless, they also affect family and caregiver functioning. This is important because the participation and involvement of families and caregivers is essential to achieve an optimal treatment. OBJECTIVE: To describe the level of expressed emotions, burden, and family functioning of bipolar and schizophrenic patients and, to evaluate the efficacy of the multimodal intervention (MI) versus traditional intervention (TI) in family functioning and its perception by patients and caregivers...
January 2017: Revista Colombiana de Psiquiatría
https://www.readbyqxmd.com/read/28187829/cross-resistance-patterns-to-acetolactate-synthase-als-inhibiting-herbicides-of-flixweed-descurainia-sophia-l-conferred-by-different-combinations-of-als-isozymes-with-a-pro-197-thr-mutation-or-a-novel-trp-574-leu-mutation
#13
Wei Deng, Qian Yang, Yongzhi Zhang, Hongtao Jiao, Yu Mei, Xuefeng Li, Mingqi Zheng
Acetolactate synthase (ALS) is the common target of ALS-inhibiting herbicides, and target-site ALS mutations are the main mechanism of resistance to ALS-inhibiting herbicides. In this study, ALS1 and ALS2 genes with full lengths of 2004bp and 1998bp respectively were cloned in individual plants of susceptible (S) or resistant (R) flixweed (Descurainia sophia L.) populations. Two ALS mutations of Pro-197-Thr and/or Trp-574-Leu were identified in plants of three R biotypes (HB24, HB30 and HB42). In order to investigate the function of ALS isozymes in ALS-inhibiting herbicide resistance, pHB24 (a Pro-197-Thr mutation in ALS1 and a wild type ALS2), pHB42 (a Trp-574-Leu mutation in ALS1 and a wild type ALS2) and pHB30 (a Trp-574-Leu mutation in ALS1 and a Pro-197-Thr mutation in ALS2) subpopulations individually homozygous for different ALS mutations were generated...
March 2017: Pesticide Biochemistry and Physiology
https://www.readbyqxmd.com/read/28187204/differentiating-founder-and-chronic-hiv-envelope-sequences
#14
John M Murray, Stephen Maher, Talia Mota, Kazuo Suzuki, Anthony D Kelleher, Rob J Center, Damian Purcell
Significant progress has been made in characterizing broadly neutralizing antibodies against the HIV envelope glycoprotein Env, but an effective vaccine has proven elusive. Vaccine development would be facilitated if common features of early founder virus required for transmission could be identified. Here we employ a combination of bioinformatic and operations research methods to determine the most prevalent features that distinguish 78 subtype B and 55 subtype C founder Env sequences from an equal number of chronic sequences...
2017: PloS One
https://www.readbyqxmd.com/read/28185212/economic-evaluations-of-new-oral-anticoagulants-for-the-prevention-of-venous-thromboembolism-after-total-hip-or-knee-replacement-a-systematic-review
#15
REVIEW
James Brockbank, Sorrel Wolowacz
BACKGROUND: Total hip replacement (THR) and total knee replacement (TKR) surgeries are being performed with increasing regularity and are associated with a high risk of developing a venous thromboembolism (VTE). New oral anticoagulants (NOACs) may be more effective at preventing VTEs but are associated with more bleeding events versus traditional anticoagulants. OBJECTIVE: The objective of this systematic review was to identify published economic analyses of NOACs for primary VTE prophylaxis following THR and TKR surgeries, and to summarise the modelling techniques used and the cost-effectiveness results...
February 10, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/28184937/rhein-exhibits-antitumorigenic-effects-by-interfering-with-the-interaction-between-prolyl-isomerase-pin1-and-c-jun
#16
Jin Hyoung Cho, Jung-Il Chae, Jung-Hyun Shim
The Pin1 protein (or peptidyl-prolyl cis/trans isomerase) specifically catalyzes the cis/trans isomerization of phosphorylated serine/threonine-proline (Ser/Thr-Pro) bonds and plays an important role in many cellular events through the effects of conformational change in the function of c-Jun, its biological substrate. Pin1 expression is involved in essential cellular pathways that mediate cell proliferation, cell cycle progression, tumorigenesis and apoptosis by altering their stability and function, and it is overexpressed in various types of tumors...
March 2017: Oncology Reports
https://www.readbyqxmd.com/read/28184362/uncemented-total-hip-replacement-after-two-years-of-neglected-hip-dislocation-with-fracture-of-posterior-column-and-wall-of-the-acetabulum
#17
Sundaresh Dc, Sharath K Ramanath, Amit Grover, Daksh Gadi
INTRODUCTION: Posterior hip dislocation of the hip with acetabular fracture is a challenging problem to treat. Such dislocations are associated with avascular necrosis of the femoral head if neglected. Managing such conditions with total hip replacement (THR) is very difficult because of associated altered anatomy. CASE PRESENTATION: We hereby report a two-year neglected hip dislocation with associated acetabular fracture successfully treated with uncemented THR...
November 2016: Trauma Monthly
https://www.readbyqxmd.com/read/28184232/bioinformatics-prediction-and-evolution-analysis-of-arabinogalactan-proteins-in-the-plant-kingdom
#18
Yuling Ma, Chenchao Yan, Huimin Li, Wentao Wu, Yaxue Liu, Yuqian Wang, Qin Chen, Haoli Ma
Arabinogalactan proteins (AGPs) are a family of extracellular glycoproteins implicated in plant growth and development. With a rapid growth in the number of genomes sequenced in many plant species, the family members of AGPs can now be predicted to facilitate functional investigation. Building upon previous advances in identifying Arabidopsis AGPs, an integrated strategy of systematical AGP screening for "classical" and "chimeric" family members is proposed in this study. A Python script named Finding-AGP is compiled to find AGP-like sequences and filter AGP candidates under the given thresholds...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28179998/phlpp-regulates-hexokinase-2-dependent-glucose-metabolism-in-colon-cancer-cells
#19
Xiaopeng Xiong, Yang-An Wen, Mihail I Mitov, Mary C Oaks, Shigeki Miyamoto, Tianyan Gao
Increased glucose metabolism is considered as one of the most important metabolic alterations adapted by cancer cells in order to generate energy as well as high levels of glycolytic intermediates to support rapid proliferation. PH domain leucine-rich repeat protein phosphatase (PHLPP) belongs to a novel family of Ser/Thr protein phosphatases that function as tumor suppressors in various types of human cancer. Here we determined the role of PHLPP in regulating glucose metabolism in colon cancer cells. Knockdown of PHLPP increased the rate of glucose consumption and lactate production, whereas overexpression of PHLPP had the opposite effect...
2017: Cell Death Discovery
https://www.readbyqxmd.com/read/28179475/asparagine-linked-glycans-of-cryptosporidium-parvum-contain-a-single-long-arm-are-barely-processed-in-the-er-or-golgi-and-show-a-strong-bias-for-sites-with-threonine
#20
John R Haserick, Deborah R Leon, John Samuelson, Catherine E Costello
Cryptosporidium parvum causes severe diarrhea in infants in developing countries and in immunosuppressed persons, including those with AIDS. We are interested in the Asn-linked glycans (N-glycans) of C. parvum, because 1) the N-glycan precursor is predicted to contain five mannose and two glucose residues on a single long arm versus nine mannose and three glucose residues on the three-armed structure common in host N-glycans, 2) C. parvum is a rare eukaryote that lacks the machinery for N-glycan-dependent quality control of protein folding in the lumen of the Endoplasmic Reticulum (ER), and 3) ER and Golgi mannosidases, as well as glycosyltransferases that build complex N-glycans, are absent from the predicted proteome...
February 8, 2017: Molecular & Cellular Proteomics: MCP
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