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pain amygdala

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https://www.readbyqxmd.com/read/29913906/using-fmri-to-evaluate-the-effects-of-milnacipran-on-central-pain-processing-in-patients-with-fibromyalgia
#1
F Petzke, K B Jensen, E Kosek, E Choy, S Carville, P Fransson, S C R Williams, H Marcus, Y Mainguy, M Ingvar, R H Gracely
Background In recent years, the prescription of serotonin-noradrenalin reuptake inhibitors (SNRIs) for treatment of fibromyalgia (FM) has increased with reports of their efficacy. The SNRI milnacipran is approved by the U.S. Food and Drug Administration (FDA) for treatment of FM, yet, the mechanisms by which milnacipran reduces FM symptoms are unknown. A large number of neuroimaging studies have demonstrated altered brain function in patients with FM but the effect of milnacipran on central pain processing has not been investigated...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913801/the-role-of-the-amygdala-in-sensory-and-emotional-like-pain-behavior-in-neuropathic-animals
#2
Antti Pertovaara
No abstract text is available yet for this article.
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913667/do-patients-with-functional-chest-pain-have-neuroplastic-reorganization-of-the-pain-matrix-a-diffusion-tensor-imaging-study
#3
Jens Brøndum Frøkjær, Andra Sorina Boldea, Dag Arne Lihaug Hoff, Anne Lund Krarup, Jan Gunnar Hatlebakk, Georg Dimcevski, Asbjørn Mohr Drewes
Background and aims In functional chest pain (FCP) of presumed esophageal origin central nervous system hyperexcitability is generally believed to play an important role in pain pathogenesis. However, this theory has recently been challenged. Using magnetic resonance diffusion tensor imaging, the aim was to characterize any microstructural reorganization of the pain neuromatrix in FCP patients. Methods 13 FCP patients and 20 matched healthy controls were studied in a 3T MR scanner. Inclusion criteria were relevant chest pain, normal coronary angiogram and normal upper gastrointestinal evaluation...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29911619/the-effect-of-tail-docking-in-neonatal-pigs-on-the-central-expression-of-genes-involved-in-modulating-anxiety-like-behaviour
#4
P Oberst, D A Sandercock, P Di Giminiani, S A Edwards, P J Brunton
Background Adverse experiences in early life, such as exposure to stress, can have long term detrimental effects on the future physiology and behaviour of the animal. Typically animals exposed to such experiences are more anxious and more reactive to stress in later life. Tail biting is a major problem in modern pig production, both in terms of animal welfare and productivity. Tail docking in early postnatal life is common practice to reduce risk of this problem, but causes pain and may alter pain sensitivity...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29908238/small-conductance-calcium-activated-potassium-sk-channel-dependent-and-independent-effects-of-riluzole-on-neuropathic-pain-related-amygdala-activity-and-behaviors-in-rats
#5
Jeremy M Thompson, Vadim Yakhnitsa, Guangchen Ji, Volker Neugebauer
BACKGROUND AND PURPOSE: Chronic neuropathic pain is an important healthcare issue with significant emotional components. The amygdala is a brain region involved in pain and emotional-affective states and disorders. The central amygdala output nucleus (CeA) contains small-conductance calcium-activated potassium (SK) channels that can control neuronal activity. A clinically available therapeutic, riluzole can activate SK channels and may have antinociceptive effects through a supraspinal action...
June 13, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29876878/role-of-the-prefrontal-cortex-in-pain-processing
#6
REVIEW
Wei-Yi Ong, Christian S Stohler, Deron R Herr
The prefrontal cortex (PFC) is not only important in executive functions, but also pain processing. The latter is dependent on its connections to other areas of the cerebral neocortex, hippocampus, periaqueductal gray (PAG), thalamus, amygdala, and basal nuclei. Changes in neurotransmitters, gene expression, glial cells, and neuroinflammation occur in the PFC during acute and chronic pain, that result in alterations to its structure, activity, and connectivity. The medial PFC (mPFC) could serve dual, opposing roles in pain: (1) it mediates antinociceptive effects, due to its connections with other cortical areas, and as the main source of cortical afferents to the PAG for modulation of pain...
June 6, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29875641/an-integrative-neuroscience-framework-for-the-treatment-of-chronic-pain-from-cellular-alterations-to-behavior
#7
Jess D Greenwald, Keith M Shafritz
Chronic pain can result from many pain syndromes including complex regional pain syndrome (CRPS), phantom limb pain and chronic low back pain, among others. On a molecular level, chronic pain syndromes arise from hypersensitization within the dorsal horn of the spinal cord, a process known as central sensitization. Central sensitization involves an upregulation of ionotropic and metabotropic glutamate receptors (mGluRs) similar to that of long-term potentiation (LTP). Regions of the brain in which LTP occurs, such as the amygdala and hippocampus, are implicated in fear- and memory-related brain circuity...
2018: Frontiers in Integrative Neuroscience
https://www.readbyqxmd.com/read/29872212/subcortical-structural-connectivity-of-insular-subregions
#8
Jimmy Ghaziri, Alan Tucholka, Gabriel Girard, Olivier Boucher, Jean-Christophe Houde, Maxime Descoteaux, Sami Obaid, Guillaume Gilbert, Isabelle Rouleau, Dang Khoa Nguyen
Hidden beneath the Sylvian fissure and sometimes considered as the fifth lobe of the brain, the insula plays a multi-modal role from its strategic location. Previous structural studies have reported cortico-cortical connections with the frontal, temporal, parietal and occipital lobes, but only a few have looked at its connections with subcortical structures. The insular cortex plays a role in a wide range of functions including processing of visceral and somatosensory inputs, olfaction, audition, language, motivation, craving, addiction and emotions such as pain, empathy and disgust...
June 5, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29868921/when-less-is-more-mindfulness-predicts-adaptive-affective-responding-to-rejection-via-reduced-prefrontal-recruitment
#9
Alexandra M Martelli, David S Chester, Kirk Warren Brown, Naomi I Eisenberger, C Nathan DeWall
Social rejection is a distressing and painful event that many people must cope with on a frequent basis. Mindfulness - defined here as a mental state of receptive attentiveness to internal and external stimuli as they arise, moment-to-moment - may buffer such social distress. However, little research indicates whether mindful individuals adaptively regulate the distress of rejection-or the neural mechanisms underlying this potential capacity. To fill these gaps in the literature, participants reported their trait mindfulness and then completed a social rejection paradigm (Cyberball) while undergoing functional MRI...
June 4, 2018: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/29733975/role-of-trpv1-and-trpv4-in-surgical-incision-induced-tissue-swelling-and-fos-like-immunoreactivity-in-the-central-nervous-system-of-mice
#10
Yasuhito Motojima, Haruki Nishimura, Hiromichi Ueno, Satomi Sonoda, Kazuaki Nishimura, Kentaro Tanaka, Reiko Saito, Mitsuhiro Yoshimura, Takashi Maruyama, Takanori Matsuura, Hitoshi Suzuki, Makoto Kawasaki, Hideo Ohnishi, Akinori Sakai, Yoichi Ueta
Pain management remains a major concern regarding the treatment of postoperative patients. Transient receptor potential (TRP) channels are considered to be new therapeutic targets for pain control. We investigated whether the genes Trpv1 and Trpv4 are involved in hind paw swelling caused after surgical incision in mice or in incision-induced Fos-like immunoreactivity (Fos-LI) levels in the central nervous system. Mice were divided into four groups: wild-type (WT) control, WT incision, Trpv1 knockout (Trpv1-/- ) incision, and Trpv4 knockout (Trpv4-/- ) incision...
May 4, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29703377/the-parabrachial-nucleus-cgrp-neurons-function-as-a-general-alarm
#11
REVIEW
Richard D Palmiter
The parabrachial nucleus (PBN), which is located in the pons and is dissected by one of the major cerebellar output tracks, is known to relay sensory information (visceral malaise, taste, temperature, pain, itch) to forebrain structures including the thalamus, hypothalamus, and extended amygdala. The availability of mouse lines expressing Cre recombinase selectively in subsets of PBN neurons and viruses for Cre-dependent gene expression is beginning to reveal the connectivity and functions of PBN component neurons...
May 2018: Trends in Neurosciences
https://www.readbyqxmd.com/read/29692727/analgesic-effects-of-duloxetine-on-formalin-induced-hyperalgesia-and-its-underlying-mechanisms-in-the-cea
#12
Lie Zhang, Jun-Bin Yin, Wei Hu, Wen-Jun Zhao, Qing-Rong Fan, Zhi-Chun Qiu, Ming-Jie He, Tan Ding, Yan Sun, Alan D Kaye, En-Ren Wang
In rodents, the amygdala has been proposed to serve as a key center for the nociceptive perception. Previous studies have shown that extracellular signal-regulated kinase (ERK) signaling cascade in the central nucleus of amygdala (CeA) played a functional role in inflammation-induced peripheral hypersensitivity. Duloxetine (DUL), a serotonin and noradrenaline reuptake inhibitor, produced analgesia on formalin-induced spontaneous pain behaviors. However, it is still unclear whether single DUL pretreatment influences formalin-induced hypersensitivity and what is the underlying mechanism...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29672451/spinal-protein-kinase-c-extracellular-signal-regulated-kinase-signal-pathway-mediates-hyperalgesia-priming
#13
Wei-Hsin Chen, Ya-Ting Chang, Yong-Cyuan Chen, Sin-Jhong Cheng, Chien-Chang Chen
Chronic pain can be initiated by one or more acute stimulations to sensitize neurons into the primed state. In the primed state, the basal nociceptive thresholds of the animal are normal, but, in response to another hyperalgesic stimulus, the animal develops enhanced and prolonged hyperalgesia. The exact mechanism of how primed state is formed is not completely understood. Here, we showed that spinal protein kinase C (PKC)/extracellular signal-regulated kinase (ERK) signal pathway is required for neuronal plasticity change, hyperalgesic priming formation, and the development of chronic hyperalgesia using acid-induced muscle pain model in mice...
May 2018: Pain
https://www.readbyqxmd.com/read/29667742/genetic-association-and-expression-analyses-of-the-phosphatidylinositol-4-phosphate-5-kinase-pip5k1c-gene-in-alcohol-use-disorder-relevance-for-pain-signaling-and-alcohol-use
#14
Ji Soo Lee, Jill L Sorcher, Allison D Rosen, Ruslan Damadzic, Hui Sun, Melanie Schwandt, Markus Heilig, John Kelly, Kelsey L Mauro, Audrey Luo, Daniel Rosoff, Christine Muench, Jeesun Jung, Zachary A Kaminsky, Falk W Lohoff
BACKGROUND: The gene encoding phosphatidylinositol-4-phosphate 5-kinase (PIP5K1C) has been recently implicated in pain regulation. Interestingly, a recent cross-tissue and cross-phenotypic epigenetic analysis identified the same gene in alcohol use disorder (AUD). Given the high comorbidity between AUD and chronic pain, we hypothesized that genetic variation in PIP5K1C might contribute to susceptibility to AUD. METHODS: We conducted a case-control association study of genetic variants in PIP5K1C...
June 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29662445/dysregulation-of-pain-and-emotion-related-networks-in-trigeminal-neuralgia
#15
Yanyang Zhang, Zhiqi Mao, Longsheng Pan, Zhipei Ling, Xinyun Liu, Jun Zhang, Xinguang Yu
Classical trigeminal neuralgia (TN) is a severe neuropathic facial pain disorder associated with increased risks of anxiety and depression. Converging evidence suggests that chronic pain pathophysiology involves dysfunctional pain-related and emotion-related networks. However, whether these systems are also among the culprit networks for TN remains unclear. Here, we aimed to assess TN-related anatomical and functional brain anomalies in pain-related and emotion-related networks. We investigated differences in gray matter (GM) volume and the related resting-state functional connectivity (rsFC) between 29 classical TN patients and 34 matched healthy controls...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29595708/brain-heart-pathways-to-blood-pressure-related-hypoalgesia
#16
Cristina Ottaviani, Sabrina Fagioli, Eugenio Mattei, Federica Censi, Louisa Edwards, Emiliano Macaluso, Marco Bozzali, Hugo Critchley, Giovanni Calcagnini
OBJECTIVE: High blood pressure (BP) is associated with reduced pain sensitivity, known as BP-related hypoalgesia. The underlying neural mechanisms remain uncertain, yet arterial baroreceptor signaling, occurring at cardiac systole, is implicated. We examined normotensives using functional neuroimaging (fMRI) and pain stimulation during distinct phases of the cardiac cycle to test the hypothesized neural mediation of baroreceptor-induced attenuation of pain. METHODS: Eighteen participants (10 women; 32...
March 28, 2018: Psychosomatic Medicine
https://www.readbyqxmd.com/read/29548885/activation-of-5-ht-2c-but-not-5-ht-1a-receptors-in-the-amygdala-enhances-fear-induced-antinociception-blockade-with-local-5-ht-2c-antagonist-or-systemic-fluoxetine
#17
Lígia Renata Rodrigues Tavares, Daniela Baptista-de-Souza, Azair Canto-de-Souza
It is well-known that the exposure of rodents to threatening environments [e.g., the open arm of the elevated-plus maze (EPM)] elicits pain inhibition. Systemic and/or intracerebral [e.g., periaqueductal gray matter, amygdala) injections of antiaversive drugs [e.g., serotonin (5-HT) ligands, selective serotonin reuptake inhibitors (SSRIs)] have been used to change EPM-open arm confinement induced antinociception (OAA). Here, we investigated (i) the role of the 5-HT1A and 5-HT2C receptors located in the amygdaloid complex on OAA as well as (ii) the effects of systemic pretreatment with fluoxetine (an SSRI) on the effects of intra-amygdala injections of 8-OH-DPAT (a 5-HT1A agonist) or MK-212 (a 5-HT2C agonist) on nociception in mice confined to the open arm or enclosed arm of the EPM...
March 13, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29524643/sequential-variation-in-brain-functional-magnetic-resonance-imaging-after-peripheral-nerve-injury-a-rat-study
#18
Okihiro Onishi, Kazuya Ikoma, Ryo Oda, Tetsuro Yamazaki, Hiroyoshi Fujiwara, Shunji Yamada, Masaki Tanaka, Toshikazu Kubo
Although treatment protocols are available, patients experience both acute neuropathic pain and chronic neuropathic pain, hyperalgesia, and allodynia after peripheral nerve injury. The purpose of this study was to identify the brain regions activated after peripheral nerve injury using functional magnetic resonance imaging (fMRI) sequentially and assess the relevance of the imaging results using histological findings. To model peripheral nerve injury in male Sprague-Dawley rats, the right sciatic nerve was crushed using an aneurysm clip, under general anesthesia...
April 23, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29520913/delineation-between-different-components-of-chronic-pain-using-dimension-reduction-an-asl-fmri-study-in-hand-osteoarthritis
#19
D Keszthelyi, Q Aziz, J K Ruffle, O O'Daly, D Sanders, K Krause, S C R Williams, M A Howard
BACKGROUND: Traditional psychometric measures aimed at characterizing the pain experience often show considerable overlap, due to interlinked affective and modulatory processes under central nervous system control. Neuroimaging studies have been employed to investigate this complexity of pain processing, in an attempt to provide a quantifiable, adjunctive description of pain perception. In this exploratory study, we examine psychometric and neuroimaging data from 38 patients with painful osteoarthritis of the carpometacarpal joint...
March 9, 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29515465/threat-response-system-parallel-brain-processes-in-pain-vis-%C3%A3-vis-fear-and-anxiety
#20
REVIEW
Igor Elman, David Borsook
Pain is essential for avoidance of tissue damage and for promotion of healing. Notwithstanding the survival value, pain brings about emotional suffering reflected in fear and anxiety, which in turn augment pain thus giving rise to a self-sustaining feedforward loop. Given such reciprocal relationships, the present article uses neuroscientific conceptualizations of fear and anxiety as a theoretical framework for hitherto insufficiently understood pathophysiological mechanisms underlying chronic pain. To that end, searches of PubMed-indexed journals were performed using the following Medical Subject Headings' terms: pain and nociception plus amygdala, anxiety, cognitive, fear, sensory, and unconscious...
2018: Frontiers in Psychiatry
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