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https://www.readbyqxmd.com/read/28228081/the-neurobiology-and-psychiatric-perspective-of-vaginismus-linking-the-pharmacological-and-psycho-social-interventions
#1
Zuri Shahidii Kadir, Hatta Sidi, Jaya Kumar, Srijit Das, Marhani Midin, Najwa Baharuddin
Vaginismus is an involuntary muscle contraction of the outer third of vaginal barrel causing sexual penetration almost impossible. It is generally classified under sexual pain disorder (SPD). In Diagnostic and Statistical Manual, 5th edition, it is classified under the new rubric of Genito-Pelvic Pain/Sexual Penetration Disorder. This fear-avoidance condition poses an ongoing significant challenge to the medical and health professionals due to the very demanding needs in health care despite its unpredictable prognosis...
February 22, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/28225716/divergent-functions-of-the-left-and-right-central-amygdala-in-visceral-nociception
#2
Katelyn E Sadler, Neal A McQuaid, Abigail C Cox, Marissa N Behun, Allison M Trouten, Benedict J Kolber
The left and right central amygdala (CeA) are limbic regions involved in somatic and visceral pain processing. These two nuclei are asymmetrically involved in somatic pain modulation; pain-like responses on both sides of the body are preferentially driven by the right CeA, and in a reciprocal fashion, nociceptive somatic stimuli on both sides of the body predominantly alter molecular and physiological activity in the right CeA. Unknown however, is whether this lateralization also exists in visceral pain processing, and furthermore, what function the left CeA has in modulating nociceptive information...
December 29, 2016: Pain
https://www.readbyqxmd.com/read/28225710/chronic-stress-exacerbates-neuropathic-pain-via-the-integration-of-stress-affect-related-information-with-nociceptive-information-in-the-central-nucleus-of-the-amygdala
#3
Ming-Jia Li, Ling-Yu Liu, Lin Chen, Jie Cai, You Wan, Guo-Gang Xing
Exacerbation of pain by chronic stress and co-morbidity of pain with stress-related psychiatric disorders including anxiety and depression, represent significant clinical challenges. However, the underlying mechanisms still remain unclear. Here, we investigated whether chronic forced swim (FS) stress-induced exacerbation of neuropathic pain is mediated by the integration of stress-affect related information with nociceptive information in the central nucleus of the amygdala (CeA). We first demonstrated that chronic FS stress (CFSS) indeed produces both depressive-like behaviors and exacerbation of spared nerve injury (SNI)-induced mechanical allodynia in rats...
December 29, 2016: Pain
https://www.readbyqxmd.com/read/28222526/the-impact-of-alzheimer-s-disease-on-the-resting-state-functional-connectivity-of-brain-regions-modulating-pain-a-cross-sectional-study
#4
Todd B Monroe, Paul A Beach, Stephen P Bruehl, Mary S Dietrich, Baxter P Rogers, John C Gore, Sebastian W Atalla, Ronald L Cowan
BACKGROUND: It is currently unknown why people with Alzheimer's disease (AD) receive less pain medication and report pain less frequently. OBJECTIVE: The purpose of this study was to determine the impact of AD on thermal psychophysics and resting-state functional connectivity (RSFC) among sensory, affective, descending modulatory, and default mode structures. METHODS: Controls (n = 23, 13 = female) and age-matched people with AD (n = 23, 13 = females) underwent psychophysical testing to rate perceptions of warmth, mild, and moderate pain and then completed resting-state fMRI...
February 7, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28180071/grey-matter-alterations-in-migraine-a-systematic-review-and-meta-analysis
#5
Zhihua Jia, Shengyuan Yu
OBJECTIVES: To summarize and meta-analyze studies on changes in grey matter (GM) in patients with migraine. We aimed to determine whether there are concordant structural changes in the foci, whether structural changes are concordant with functional changes, and provide further understanding of the anatomy and biology of migraine. METHODS: We searched PubMed and Embase for relevant articles published between January 1985 and November 2015, and examined the references within relevant primary articles...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28162615/-375-asymmetric-modulation-of-bladder-pain-by-the-left-and-right-central-amygdala
#6
K Sadler, B Kolber
No abstract text is available yet for this article.
April 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28162597/-355-riluzole-actions-on-sk-channels-in-the-amygdala-in-acute-arthritic-and-chronic-neuropathic-pain
#7
J Thompson, G Ji, V Neugebauer
No abstract text is available yet for this article.
April 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28129556/neural-responses-to-social-threat-and-predictors-of-cognitive-behavioral-therapy-and-acceptance-and-commitment-therapy-in-social-anxiety-disorder
#8
Lisa J Burklund, Jared B Torre, Matthew D Lieberman, Shelley E Taylor, Michelle G Craske
Previous research has often highlighted hyperactivity in emotion regions to simple, static social threat cues in social anxiety disorder (SAD). Investigation of the neurobiology of SAD using more naturalistic paradigms can further reveal underlying mechanisms and how these relate to clinical outcomes. We used fMRI to investigate responses to novel dynamic rejection stimuli in individuals with SAD (N=70) and healthy controls (HC; N=17), and whether these responses predicted treatment outcomes following cognitive behavioral therapy (CBT) or acceptance and commitment therapy (ACT)...
December 28, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/28119507/pain-mediated-affect-regulation-is-reduced-after-dialectical-behavior-therapy-in-borderline-personality-disorder-a-longitudinal-fmri-study
#9
Inga Niedtfeld, Ruth Schmitt, Dorina Winter, Martin Bohus, Christian Schmahl, C Sabine, Herpertz
Borderline Personality Disorder (BPD) is characterized by affective instability, but selfinjurious behavior appears to have an emotion-regulating effect. We investigated whether pain-mediated affect regulation can be altered at the neural level by residential Dialectical Behavior Therapy (DBT), providing adaptive emotion regulation techniques. Likewise, we investigated whether pain thresholds or the appraisal of pain change after psychotherapy.We investigated 28 patients with BPD undergoing DBT (self-referral), 15 patients with treatment as usual, and 23 healthy control subjects at two time points twelve weeks apart...
January 24, 2017: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/28116559/altered-functional-connectivity-of-amygdala-underlying-the-neuromechanism-of-migraine-pathogenesis
#10
Zhiye Chen, Xiaoyan Chen, Mengqi Liu, Zhao Dong, Lin Ma, Shengyuan Yu
BACKGROUND: The amygdala is a large grey matter complex in the limbic system, and it may contribute in the neurolimbic pain network in migraine. However, the detailed neuromechanism remained to be elucidated. The objective of this study is to investigate the amygdala structural and functional changes in migraine and to elucidate the mechanism of neurolimbic pain-modulating in the migraine pathogenesis. METHODS: Conventional MRI, 3D structure images and resting state functional MRI were performed in 18 normal controls (NC), 18 patients with episodic migraine (EM), and 16 patients with chronic migraine (CM)...
December 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28111628/the-prefrontal-cortex-as-a-critical-gate-of-negative-affect-and-motivation-in-alcohol-use-disorder
#11
Amanda R Pahng, M Adrienne McGinn, Rod I Paulsen, Scott Edwards
The prefrontal cortex (PFC) represents and executes the highest forms of goal-directed behavior, and has thereby attained a central neuroanatomical position in most pathophysiological conceptualizations of motivational disorders, including alcohol use disorder (AUD). Excessive, intermittent exposure to alcohol produces an allostatic dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis along with heightened forebrain glucocorticoid signaling that can damage PFC architecture and function. Negative affective states intimately associated with the transition to alcohol dependence result not only from a dysregulated HPA axis, but also from the inability of a damaged PFC to regulate subcortical stress and reinforcement centers, including the ventral striatum and amygdala...
February 2017: Current Opinion in Behavioral Sciences
https://www.readbyqxmd.com/read/28087191/alterations-of-brain-activity-in-fibromyalgia-patients
#12
REVIEW
Passakorn Sawaddiruk, Sahattaya Paiboonworachat, Nipon Chattipakorn, Siriporn C Chattipakorn
Fibromyalgia is a chronic pain syndrome, characterized by widespread musculoskeletal pain with diffuse tenderness at multiple tender points. Despite intense investigations, the pathophysiology of fibromyalgia remains elusive. Evidence shows that it could be due to changes in either the peripheral or central nervous system (CNS). For the CNS changes, alterations in the high brain area of fibromyalgia patients have been investigated but the definite mechanisms are still unclear. Magnetic Resonance Imaging (MRI) and Functional Magnetic Resonance (fMRI) have been used to gather evidence regarding the changes of brain morphologies and activities in fibromyalgia patients...
January 10, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28057459/parabrachial-pituitary-adenylate-cyclase-activating-polypeptide-activation-of-amygdala-endosomal-extracellular-signal-regulated-kinase-signaling-regulates-the-emotional-component-of-pain
#13
Galen Missig, Linda Mei, Margaret A Vizzard, Karen M Braas, James A Waschek, Kerry J Ressler, Sayamwong E Hammack, Victor May
BACKGROUND: Chronic pain and stress-related psychopathologies, such as depression and anxiety-associated abnormalities, are mutually reinforcing; however, the neuronal circuits and mechanisms that underlie this reinforcement are still not well understood. Pituitary adenylate cyclase activating polypeptide (PACAP; Adcyap1) and its cognate PAC1 receptor (Adcyap1r1) are expressed in peripheral nociceptive pathways, participate in anxiety-related responses and have been have been linked to posttraumatic stress disorder and other mental health afflictions...
August 29, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/28033157/measuring-glutamate-levels-in-the-brains-of-fibromyalgia-patients-and-a-potential-role-for-glutamate-in-the-pathophysiology-of-fibromyalgia-symptoms-a-systematic-review
#14
Tahni Pyke, Peter G Osmotherly, Surinder Baines
OBJECTIVES: The aim of this study is to systematically review the literature concerning proton magnetic resonance spectroscopy (H-MRS) measured glutamate levels in specific brain regions of fibromyalgia (FM) patients to determine if there is a correlation between raised glutamate levels and the presentation of FM. METHODS: The electronic databases - MEDLINE, EMBASE Classic+Embase, PsychINFO, Cochrane Database of Systematic Reviews, Cochrane Database of Abstracts of Reviews of Effect, Cochrane Central Register of Controlled Trials - were searched to find original studies that used H-MRS to measure glutamate concentrations in the brains of FM patients...
December 28, 2016: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28028808/structural-gray-matter-alterations-in-chronic-migraine-implications-for-a-progressive-disease
#15
Lars Neeb, Kaili Bastian, Kersten Villringer, Heike Israel, Uwe Reuter, Jochen B Fiebach
OBJECTIVE: To identify possible gray matter alterations in patients with chronic migraine using voxel-based morphometry (VBM). BACKGROUND: VBM studies demonstrate structural alterations of gray matter (GM) in episodic migraine (EM) patients. Some of these alterations correlate with disease duration and headache frequency. We assessed GM alterations in chronic migraine (CM) and EM to evaluate the concept of migraine as a progressive disorder of the brain. METHODS: Individually age and sex-matched subjects with CM or EM (both without aura) and healthy controls (n = 21 per group) underwent magnetic resonance imaging-based VBM...
December 28, 2016: Headache
https://www.readbyqxmd.com/read/28011743/5-ht2c-receptor-knockdown-in-the-amygdala-inhibits-neuropathic-pain-related-plasticity-and-behaviors
#16
Guangchen Ji, Wei Zhang, Lenin Mahimainathan, Madhusudhanan Narasimhan, Takaki Kiritoshi, Xiuzhen Fan, Jigong Wang, Thomas A Green, Volker Neugebauer
Neuroplasticity in the amygdala drives pain-related behaviors. The central nucleus (CeA) serves major amygdala output functions and can generate emotional-affective behaviors and modulate nocifensive responses. The CeA receives excitatory and inhibitory inputs from the basolateral nucleus (BLA) and serotonin receptor subtype 5-HT2CR in the BLA, but not CeA, has been implicated anxiogenic behaviors and anxiety disorders. Here, we tested the hypothesis that 5-HT2CR in the BLA plays a critical role in CeA plasticity and neuropathic pain behaviors in the rat spinal nerve ligation (SNL) model...
February 8, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28009270/healing-pains-of-the-past-using-neuronal-transplantation
#17
XiaoTing Zheng, Sunil P Gandhi
Yang et al. (2016) show that transplantation of GABAergic inhibitory neurons into the amygdala boosts the persistence of fear extinction in mice. Transplantation was found to degrade perineuronal nets on endogenous inhibitory neurons and enhance synaptic plasticity in host amygdala.
December 21, 2016: Neuron
https://www.readbyqxmd.com/read/28008077/anxious-anticipation-and-pain-the-influence-of-instructed-vs-conditioned-threat-on-pain
#18
Philipp Reicherts, Julian Wiemer, Antje B M Gerdes, Stefan M Schulz, Paul Pauli, Matthias J Wieser
Negative emotions such as anxiety enhance pain perception. However, certain threat characteristics are discussed to have different or even divergent effects on pain (hypoalgesia vs hyperalgesia). In order to investigate the neurobiological basis of different threats, we compared the impact of conditioned threat (CT) vs instructed threat (IT) on pain using fMRI. In two groups, participants underwent either Pavlovian threat conditioning or an instructed threat procedure. Afterwards, in an identical test phase participants watched the same visual cues from the previous phase indicating potential threat or safety, and received painful thermal stimulation...
December 21, 2016: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/28000999/n-ofq-system-in-brain-areas-of-nerve-injured-mice-its-role-in-different-aspects-of-neuropathic-pain
#19
M Palmisano, D Mercatelli, F F Caputi, D Carretta, P Romualdi, S Candeletti
Several studies showed that chronic pain causes reorganization and functional alterations of supraspinal brain regions. The nociceptin-NOP receptor system is one of the major systems involved in pain control and much evidence also suggested its implication in stress, anxiety and depression. Therefore, we investigated the nociceptin-NOP system alterations in selected brain regions in a neuropathic pain murine model. Fourteen days after the common sciatic nerve ligature, PCR analysis indicated a significant decrease of pronociceptin and NOP receptor mRNA levels in the thalamus; these alterations could contribute to the decrease of the thalamic inhibitory function reported in neuropathic pain condition...
December 21, 2016: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/27994221/dynamic-modulation-of-inflammatory-pain-related-affective-and-sensory-symptoms-by-optical-control-of-amygdala-metabotropic-glutamate-receptor-4
#20
C Zussy, X Gómez-Santacana, X Rovira, D De Bundel, S Ferrazzo, D Bosch, D Asede, F Malhaire, F Acher, J Giraldo, E Valjent, I Ehrlich, F Ferraguti, J-P Pin, A Llebaria, C Goudet
Contrary to acute pain, chronic pain does not serve as a warning signal and must be considered as a disease per se. This pathology presents a sensory and psychological dimension at the origin of affective and cognitive disorders. Being largely refractory to current pharmacotherapies, identification of endogenous systems involved in persistent and chronic pain is crucial. The amygdala is a key brain region linking pain sensation with negative emotions. Here, we show that activation of a specific intrinsic neuromodulatory system within the amygdala associated with type 4 metabotropic glutamate receptors (mGlu4) abolishes sensory and affective symptoms of persistent pain such as hypersensitivity to pain, anxiety- and depression-related behaviors, and fear extinction impairment...
December 20, 2016: Molecular Psychiatry
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