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https://www.readbyqxmd.com/read/29334416/investigating-causal-associations-between-use-of-nicotine-alcohol-caffeine-and-cannabis-a-two-sample-bidirectional-mendelian-randomization-study
#1
Karin J H Verweij, Jorien L Treur, Jacqueline M Vink
BACKGROUND AND AIMS: Epidemiological studies consistently show co-occurrence of use of different addictive substances. Whether these associations are causal or due to overlapping underlying influences remains an important question in addiction research. Methodological advances have made it possible to use published genetic associations to infer causal relationships between phenotypes. In this exploratory study, we used Mendelian randomization (MR) to examine the causality of well-established associations between nicotine, alcohol, caffeine, and cannabis use...
January 15, 2018: Addiction
https://www.readbyqxmd.com/read/29333381/changes-in-drosophila-melanogaster-sleep-wake-behavior-due-to-lotus-nelumbo-nucifera-seed-and-hwang-jeong-polygonatum-sibiricum-extracts
#2
Kyungae Jo, SangDuk Jeon, Chang-Won Ahn, Sung Hee Han, Hyung Joo Suh
We evaluated the sleep enhancement activity of the medicinal herbs valerian (Valeriana officinalis), jujube (Ziziphus jujube), lotus seed (Nelumbo nucifera), Gastrodia elata, Polygonatum sibiricum, and baekbokryung (Poria cocos), which can relieve insomnia in a Drosophila model. Locomotor activity was measured in the Drosophila model to evaluate the sleep activity of Korean medicinal herbs traditionally used as sleep aids. The group treated with lotus seed extract showed less nocturnal activity. Treatment with 10 or 20 mg/mL of P...
December 2017: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/29332148/occurrence-of-pharmaceuticals-and-personal-care-products-and-their-associated-environmental-risks-in-a-large-shallow-lake-in-north-china
#3
Panwei Zhang, Huaidong Zhou, Kun Li, Xiaohui Zhao, Qiaona Liu, Dongjiao Li, Gaofeng Zhao
Eighteen selected pharmaceuticals and personal care products (PPCPs), consisting of five non-antibiotic pharmaceuticals (N-APs), four sulfonamides (SAs), four tetracyclines (TCs), four macrolides (MCs), and one quinolone (QN) were detected in water, pore water, and sediment samples from Baiyangdian Lake, China. A total of 31 water samples and 29 sediment samples were collected in March 2017. Caffeine was detected with 100% frequency in surface water, pore water, and sediment samples. Carbamazepine was detected with 100% frequency in surface water and sediment samples...
January 13, 2018: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/29331442/coffee-consumption-and-risk-of-hypertension-in-the-sun-project
#4
A M Navarro, M A Martinez-Gonzalez, A Gea, R Ramallal, M Ruiz-Canela, E Toledo
BACKGROUND & AIMS: Evidence on coffee consumption and its association with the incidence of hypertension is still inconsistent. The aim of this study was to examine the association of regular or decaffeinated coffee consumption with the risk of developing hypertension in a middle-aged Mediterranean cohort. METHODS: The SUN Project is a prospective open cohort with more than 22,500 Spanish university graduates. For the present study, we analyzed data from 13,374 participants initially free of hypertension (mean follow-up 9...
December 21, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29329947/-pseudoexfoliation-syndrome-and-pseudoexfoliation-glaucoma
#5
REVIEW
C Schweitzer
Pseudoexfoliation syndrome is an age-related systemic disease that mainly affects the anterior structures of the eye. Despite a worldwide distribution, reported incidence and prevalence of this syndrome vary widely between ethnicities and geographical areas. The exfoliative material is composed mainly of abnormal cross-linked fibrils that accumulate progressively in some organs such as the heart, blood vessels, lungs or meninges, and particularly in the anterior structures of the eye. The exact pathophysiological process still remains unclear but the association of genetic and environmental factors are thought to play a role in the development and progressive extracellular accumulation of exfoliative material...
January 9, 2018: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29329833/effect-of-brewing-time-and-temperature-on-antioxidant-capacity-and-phenols-of-white-tea-relationship-with-sensory-properties
#6
S Pérez-Burillo, R Giménez, J A Rufián-Henares, S Pastoriza
White tea is highly consumed due to its sensory properties and health benefits, although most scientific reports don't include the analysis of both properties. Therefore, the objective of the present study was to unravel the best brewing conditions for optimal extraction of the bioactive compounds and antioxidant capacity, while realising the best sensory properties. Infusions of eighty commercial teas (sold in bags or leaves) were obtained at different time-temperature ratios, studying bioactive compounds (caffeine and individual catechins), antioxidant capacity and sensory analysis...
May 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29327202/transient-disruption-of-adenosine-signaling-during-embryogenesis-triggers-a-pro-epileptic-phenotype-in-adult-zebrafish
#7
Fabiano Peres Menezes, Felipe Machado Torresini, Laura Roesler Nery, Rosane Souza da Silva
Adenosinergic signaling has important effects on brain function, anatomy, and physiology in both late and early stages of development. Exposure to caffeine, a non-specific blocker of adenosine receptor, has been indicated as a developmental risk factor. Disruption of adenosinergic signaling during early stages of development can change the normal neural network formation and possibly lead to an increase in susceptibility to seizures. In this work, morpholinos (MO) temporarily blocked the translation of adenosine receptor transcripts, adora1, adora2aa, and adora2ab, during the embryonic phase of zebrafish...
January 11, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29326967/hr-tem-and-ft-raman-dataset-of-the-caffeine-interacted-phe-phe-peptide-nanotube-for-possible-sensing-applications
#8
A Lakshmi Narayanan, M Dhamodaran, J Samu Solomon, B Karthikeyan, R Govindhan
Sensing ability of caffeine interaction with Phe-Phe annotates (PNTs), is presented (Govindhan et al., 2017; Karthikeyan et al., 2014; Tavagnacco et al., 2013; Kennedy et al., 2011; Wang et al., 2017) [1-5] in this data set. Investigation of synthesized caffeine carrying peptide nanotubes are carried out by FT-Raman spectral analysis and high resolution transmission electron microscopy (HR-TEM). Particle size of the caffeine loaded PNTs is < 40 nm. The FT-Raman spectrum signals are enhanced in the region of 400-1700 cm-1...
February 2018: Data in Brief
https://www.readbyqxmd.com/read/29325962/systematic-review-of-factors-influencing-surgical-performance-practical-recommendations-for-microsurgical-procedures-in-neurosurgery
#9
Evgenii Belykh, Naomi R Onaka, Iraklii T Abramov, Kaan Yağmurlu, Vadim A Byvaltsev, Robert F Spetzler, Peter Nakaji, Mark C Preul
BACKGROUND: Microneurosurgical techniques involve complex manual skills and hand-eye coordination that require substantial training. Many factors affect microneurosurgical skills. The goal of this study was to use a systematic evidence-based approach to analyze the quality of evidence for intrinsic and extrinsic factors that influence microneurosurgical performance and to make weighted practical recommendations. MATERIALS AND METHODS: A literature search of factors that may impact microsurgical performance was conducted using PubMed and Embase...
January 8, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29324069/evidence-based-guidelines-for-fatigue-risk-management-in-emergency-medical-services
#10
P Daniel Patterson, J Stephen Higgins, Hans P A Van Dongen, Daniel J Buysse, Ronald W Thackery, Douglas F Kupas, David S Becker, Bradley E Dean, George H Lindbeck, Francis X Guyette, Josef H Penner, John M Violanti, Eddy S Lang, Christian Martin-Gill
BACKGROUND: Administrators of Emergency Medical Services (EMS) operations lack guidance on how to mitigate workplace fatigue, which affects greater than half of all EMS personnel. The primary objective of the Fatigue in EMS Project was to create an evidence-based guideline for fatigue risk management tailored to EMS operations. METHODS: Systematic searches were conducted from 1980 to September 2016 and guided by seven research questions framed in the Population, Intervention, Comparison, Outcome (PICO) framework...
January 11, 2018: Prehospital Emergency Care
https://www.readbyqxmd.com/read/29324066/systematic-review-and-meta-analysis-of-the-effects-of-caffeine-in-fatigued-shift-workers-implications-for-emergency-medical-services-personnel
#11
Jennifer L Temple, David Hostler, Christian Martin-Gill, Charity G Moore, Patricia M Weiss, Denisse J Sequeira, Joseph P Condle, Eddy S Lang, J Stephen Higgins, P Daniel Patterson
BACKGROUND: Emergency Medical Services (EMS) workers may experience fatigue as a consequence of shift work. We reviewed the literature to determine the impact of caffeine as a countermeasure to fatigue in EMS personnel and related shift workers. METHODS: We employed the GRADE methodology to perform a systematic literature review and search multiple databases for research that examined the impact of caffeine on outcomes of interest, such as patient and EMS personnel safety...
January 11, 2018: Prehospital Emergency Care
https://www.readbyqxmd.com/read/29324060/proposed-performance-measures-and-strategies-for-implementation-of-the-fatigue-risk-management-guidelines-for-emergency-medical-services
#12
Christian Martin-Gill, J Stephen Higgins, Hans P A Van Dongen, Daniel J Buysse, Ronald W Thackery, Douglas F Kupas, David S Becker, Bradley E Dean, George H Lindbeck, Francis X Guyette, Josef H Penner, John M Violanti, Eddy S Lang, P Daniel Patterson
BACKGROUND: Performance measures are a key component of implementation, dissemination, and evaluation of evidence-based guidelines (EBGs). We developed performance measures for Emergency Medical Services (EMS) stakeholders to enable the implementation of guidelines for fatigue risk management in the EMS setting. METHODS: Panelists associated with the Fatigue in EMS Project, which was supported by the National Highway Traffic Safety Administration (NHTSA), used an iterative process to develop a draft set of performance measures linked to 5 recommendations for fatigue risk management in EMS...
January 11, 2018: Prehospital Emergency Care
https://www.readbyqxmd.com/read/29322637/maternal-exposures-and-risk-of-oral-clefts-in-south-vietnam
#13
Vu H A Dien, Christy M McKinney, Araya Pisek, Waranuch Pitiphat
BACKGROUND: Oral clefts are among the most common congenital anomalies. Most studies on risk factors of oral clefts have been carried out in developed countries. We investigated the associations between maternal exposures in the first trimester and oral clefts in South Vietnam. METHODS: We conducted a hospital-based case-control study during October 2014-November 2015. Cases included 170 patients with nonsyndromic cleft lip with or without cleft palate and those with cleft palate only...
January 11, 2018: Birth Defects Research
https://www.readbyqxmd.com/read/29320928/interaction-of-caffeine-and-sulfadiazine-with-lysozyme-adsorbed-at-colloidal-metal-nanoparticle-interface-influence-on-drug-transport-ability-and-antibacterial-activity
#14
Vikash K Sonu, Imocha Rajkumar, Kaushik Bhattacharjee, S R Joshi, Sivaprasad Mitra
The modulated bioactivity of proteins immobilized on nanoparticle (NP) interfaces is of tremendous interest towards designing better therapeutic and diagnostic tools. In this work, binding behavior and the antibacterial activity of free lysozyme (LYS) as well as its non-covalent assembly with silver (Ag) and gold (Au) colloidal NPs were compared in presence of two model drugs, viz. sulfadiazine (SDZ) and caffeine (CAF). Intrinsic protein fluorescence was found to quench due to the formation drug-protein complex in case of CAF resulting a linear Stern-Volmer (SV) plot with KSV = 1...
January 11, 2018: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29318895/acute-effect-of-coffee-on-aortic-stiffness-and-wave-reflections-in-healthy-individuals-differential-effect-according-to-habitual-consumption
#15
Nikolaos Ioakeimidis, Vaios Tzifos, Charalambos Vlachopoulos, Dimitrios Terentes-Printzios, Christos Georgakopoulos, Dimitrios Tousoulis
The acute effect of coffee on arterial stiffness and its dependence on habitual consumption was studied in 24 volunteers on four separate occasions during which subjects received: (a) coffee espresso, (b) decaffeinated coffee espresso, (c) caffeine alone and (d) placebo (hot water). The increase in carotid femoral pulse wave velocity (PWV), augmentation index (AIx) and augmented pressure (AP) of the aortic pressure waveform after coffee consumption was more pronounced in non-habitual (n = 13) compared to habitual drinkers (n = 11), (differences of maximal changes between groups in PWV, AIx, AP responses by 0...
January 10, 2018: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/29318792/hemodynamic-effects-on-systemic-blood-flow-and-ductal-shunting-flow-after-loading-dose-of-intravenous-caffeine-in-preterm-infants-according-to-the-patency-of-ductus-arteriosus
#16
Jihye Hwang, Yu Seon Kim, Jeong Hee Shin, Byung Min Choi
BACKGROUND: In preterm infants, caffeine citrate is used to stimulate breathing before they are weaned from mechanical ventilation and to reduce the frequency of apnea. In recent studies, effects of caffeine on the cardiovascular system have been emphasized in preterm infants with patent ductus arteriosus (PDA). METHODS: This study aimed to assess the short-term hemodynamic effects on systemic blood flow and ductal shunting flow after loading standard doses of intravenous caffeine in preterm infants...
January 22, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29318639/interaction-between-caffeine-and-polymorphisms-of-glutamate-ionotropic-receptor-nmda-type-subunit-2a-grin2a-and-cytochrome-p450-1a2-cyp1a2-on-parkinson-s-disease-risk
#17
Iris Y Kim, Éilis J O'Reilly, Katherine C Hughes, Xiang Gao, Michael A Schwarzschild, Marjorie L McCullough, Marian T Hannan, Rebecca A Betensky, Alberto Ascherio
BACKGROUND: Caffeine intake has been inversely associated with Parkinson's disease (PD) risk. This relationship may be modified by polymorphisms of glutamate ionotropic receptor NMDA type subunit 2A (GRIN2A) and cytochrome P450 1A2 (CYP1A2), but the results of previous studies have been inconsistent. METHOD: We examined the interaction of caffeine intake with GRIN2A-rs4998386 and CYP1A2-rs762551 polymorphisms in influencing PD risk among 829 incident cases of PD and 2,754 matched controls selected among participants in the following 3 large prospective ongoing cohorts: the Nurses' Health Study, the Health Professionals' Follow-up Study, and the Cancer Prevention Study II Nutrition Cohort...
January 10, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29318131/rhabdomyolysis-from-resistance-exercise-and-caffeine-intake
#18
Dong Jun Sung, Eun-Ju Choi, Sojung Kim, Jooyoung Kim
No abstract text is available yet for this article.
January 2018: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/29317951/parafunctional-behaviors-and-its-effect-on-dental-bridges
#19
REVIEW
Amal Alharby, Hanan Alzayer, Ahmed Almahlawi, Yazeed Alrashidi, Samaa Azhar, Maan Sheikho, Anas Alandijani, Amjad Aljohani, Manal Obied
Parafunctional behaviors, especially bruxism, are not uncommon among patient visiting dentists' clinics daily and they constitute a major dental issue for almost all dentists. Many researchers have focused on the definition, pathophysiology, and treatment of these behaviors. These parafunctional behaviors have a considerable negative impact on teeth and dental prothesis. In this review, we focused on the impact of parafunctional behaviors on dental bridges. We summarized the definitions, epidemiology, pathophysiology, and consequences of parafunctional behaviors...
February 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29317921/baseline-knowledge-of-potential-pet-toxins-a-survey-of-pharmacists
#20
Natalie W Young, Kenneth D Royal, Gigi S Davidson
Background: Consumer expenditures on their family pets are rapidly increasing, part of which can be attributed to prescription and OTC medications. In turn, community pharmacies are seeking and receiving an increased number of prescriptions for animals. Community pharmacists' ability to safely care for animal patients is relatively unexplored. Human medications, their normal dosing and even medication excipients could be lethal in some animal patients. Objective: The overarching objective of this study was to assess pharmacists' baseline knowledge of potential pet poisons...
October 2017: Pharmacy Practice
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