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https://www.readbyqxmd.com/read/28211649/insufficient-sleep-in-adolescents-causes-and-consequences
#1
Judith A Owens, Miriam R Weiss
Insufficient sleep poses an important and complicated set of health risks in the adolescent population. Not only is deficient sleep (defined as both sleep duration inadequate to meet sleep needs and sleep timing misaligned with the body's circadian rhythms) at epidemic levels in this population, but the contributing factors are both complex and numerous and there are a myriad of negative physical and mental health, safety and performance consequences. Causes of inadequate sleep identified in this population include internal biological processes such as the normal shift (delay) in circadian rhythm that occurs in association with puberty and a developmentally-based slowing of the "sleep drive", and external factors including extracurricular activities, excessive homework load, evening use of electronic media, caffeine intake and early school start times...
February 17, 2017: Minerva Pediatrica
https://www.readbyqxmd.com/read/28207926/alcohol-mixed-with-energy-drinks-daily-context-of-use
#2
Ashley N Linden-Carmichael, Cathy Lau-Barraco
The link between use of alcohol mixed with energy drinks (AmEDs) and alcohol-related harms is well established, but limited research has examined the context in which AmEDs are consumed. Identifying the social and environmental characteristics of use may illuminate whether AmEDs are used in settings that could increase the likelihood of engaging in risky behaviors or experiencing harms. The present study used a two-week daily diary assessment to compare days in which AmEDs were consumed ("AmED days") and days where other types of alcohol were used ("non-AmED days") on where, when, and with whom drinking occurred METHODS: Participants were 122 (90 women) heavy drinking college students who reported mixing caffeine with alcohol at least once in the past week...
February 16, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28206974/caffeine-delays-oocyte-aging-and-maintains-the-quality-of-aged-oocytes-safely-in-mouse
#3
Xia Zhang, Xiaoyan Liu, Li Chen, Dan-Ya Wu, Zheng-Wen Nie, Ying-Ying Gao, Yi-Liang Miao
Caffeine, as an oocyte aging inhibitor, was used in many different species to control or delay oocyte aging. However, the safety of caffeine and developmental competence of aged oocytes inhibited by caffeine has not been studied systematically. So we detected the spindle morphology, distribution of cortical granules, zona pellucida hardening and pronucleus formation to assess oocyte quality of caffeine treated oocytes. We found that aged oocytes treated by caffeine maintained weak susceptibility to activating stimuli and regained normal competent after aged further 6 hr...
February 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28203771/a-rapid-uplc-method-for-simultaneous-analysis-of-caffeine-and-13-index-polyphenols-in-black-tea
#4
Hai-Bo Pan, Dan Zhang, Bo Li, Yuan-Yuan Wu, You-Ying Tu
No abstract text is available yet for this article.
February 14, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28202385/long-term-consequences-of-disrupting-adenosine-signaling-during-embryonic-development
#5
REVIEW
Scott A Rivkees, Christopher C Wendler
There is growing evidence that disruption in the prenatal environment can have long-lasting effects on an individual's health in adulthood. Research on the fetal programming of adult diseases, including cardiovascular disease, focuses on epi-mutations, which alter the normal pattern of epigenetic factors such as DNA methylation, miRNA expression, or chromatin modification, rather than traditional genetic alteration. Thus, understanding how in utero chemical exposures alter epigenetics and lead to adult disease is of considerable public health concern...
February 12, 2017: Molecular Aspects of Medicine
https://www.readbyqxmd.com/read/28198658/effects-of-acute-and-chronic-caffeine-on-risk-taking-behavior-in-children-and-adolescents
#6
Jennifer L Temple, Amanda M Ziegler, Adam M Graczyk, Amanda Crandall
Consumption of caffeinated beverages is associated with increased risk-taking behavior. The purpose of this study was to determine if acute caffeine administration influences risk-taking behavior in a dose-dependent manner. Participants were pre- (ages 8-9) and post-pubertal (ages 15-17) children who visited the laboratory three times and consumed a beverage containing 0, 1, or 2 mg/kg of caffeine. Thirty minutes later, participants completed the balloon analogue risk task (BART), the Iowa gambling task (IGT), and a delay discounting task...
February 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28198465/fatigue-related-impairments-in-oculomotor-control-are-prevented-by-norepinephrine-dopamine-reuptake-inhibition
#7
Charlotte J W Connell, Benjamin Thompson, Jason Turuwhenua, Alexa Srzich, Nicholas Gant
Fatigue-induced reductions in saccade velocity have been reported following acute, prolonged exercise. Interestingly, the detrimental impact of fatigue on oculomotor control can be prevented by a moderate dose of caffeine. This effect may be related to central catecholamine upregulation via caffeine's action as an adenosine antagonist. To test this hypothesis, we compared the protective effect of caffeine on oculomotor control post-exercise to that of a norepinephrine-dopamine reuptake inhibitor. Within a placebo-controlled crossover design, 12 cyclists consumed placebo, caffeine or a norepinephrine-dopamine reuptake inhibitor (bupropion) during 180 minutes of stationary cycling...
February 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28196026/caffeine-inhibits-fluid-secretion-by-interlobular-ducts-from-guinea-pig-pancreas
#8
Yuka Mochimaru, Akiko Yamamoto, Miyuki Nakakuki, Makoto Yamaguchi, Ituka Taniguchi, Hiroshi Ishiguro
OBJECTIVES: Caffeine is contained in coffee, tea, and a lot of beverages and foods. We examined the direct effects of caffeine on the physiological function of pancreatic duct cells by using interlobular duct segments isolated from guinea pig pancreas. METHODS: The rate of fluid secretion was continuously measured by monitoring the luminal volume of isolated duct segments. Changes in intracellular Ca concentration ([Ca]i) were estimated by microfluorometry in ducts loaded with fura-2...
February 14, 2017: Pancreas
https://www.readbyqxmd.com/read/28194561/xanthine-alkaloids-occurrence-biosynthesis-and-function-in-plants
#9
Hiroshi Ashihara, Kouichi Mizuno, Takao Yokota, Alan Crozier
Caffeine is a xanthine alkaloid found in non-alcoholic beverages such as tea, coffee, and cocoa. It was discovered in tea and coffee in the 1820s, but it was not until 2000 that details of molecular events associated with caffeine biosynthesis began to be unraveled. Reviewed are the occurrence of xanthine alkaloids in the plant kingdom and the elucidation of the caffeine biosynthesis pathway, providing details of the N-methyltransferases, belonging to the motif B' methyltransferase family, which catalyze three steps in the four-step pathway leading from xanthosine to caffeine...
2017: Progress in the Chemistry of Organic Natural Products
https://www.readbyqxmd.com/read/28192967/direct-analysis-of-xanthine-stimulants-in-archaeological-vessels-by-laser-desorption-rempi
#10
Shawn C Owens, Jacob Berenbeim, Marshall Ligare, Lisa E Gulian, Faady M Siouri, Samuel Boldissar, Stuart Tyson-Smith, Gregory Daniel Wilson, Anabel Ford, Mattanjah S De Vries
Resonance enhanced multiphoton ionization spectroscopy (REMPI) generates simultaneous vibronic spectroscopy and fragment free mass spectrometry to identify molecules within a complex matrix. We combined laser desorption with REMPI spectroscopy to study organic residues within pottery sherds from Maya vessels (600-900 CE) and Missisippian vessels (1100-1200 CE), successfully detecting three molecular markers, caffeine, theobromine and theophylline, associated with the use of cacao. This analytical approach provides a high molecular specificity, based on both wavelength and mass identification...
February 2, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28192609/effect-of-vitamin-d3-fortification-and-saskatoon-berry-syrup-addition-on-the-flavor-profile-acceptability-and-antioxidant-properties-of-rooibos-tea-aspalathus-linearis
#11
Jennifer Grant, Donna Ryland, Cara K Isaak, Suvira Prashar, Yaw L Siow, Carla G Taylor, Michel Aliani
The unique characteristics and healthful reputation of caffeine-free rooibos tea (RT) make it an ideal carrier for vitamin D3 supplementation, and a potential base for the addition of Saskatoon berry syrup (SBS), a natural flavor additive. The objective of this study was to determine the effect of vitamin D3 fortification and SBS addition on the flavor profile, consumer acceptability, and antioxidant properties of RT. Six formulations (RT, RT with SBS, RT with SBS and vitamin D3 , RT with vitamin D3 , green tea [GT], and GT with SBS) were evaluated by 12 trained panelists and 114 consumers...
February 13, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28190575/water-quality-variables-and-pollution-sources-shaping-stream-macroinvertebrate-communities
#12
Elisabeth Berger, Peter Haase, Mathias Kuemmerlen, Moritz Leps, Ralf Bernhard Schäfer, Andrea Sundermann
In 2015, over 90 percent of German rivers failed to reach a good ecological status as demanded by the EU Water Framework Directive (WFD). Deficits in water quality, mainly from diffuse pollution such as agricultural run-off, but also from wastewater treatment plants (WWTPs), have been suggested as important drivers of this decline in ecological quality. We modelled six macroinvertebrate based metrics indicating ecological quality for 184 streams in response to a) PCA-derived water quality gradients, b) individual water quality variables and c) catchment land use and wastewater exposure indices as pollution drivers...
February 9, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28188930/microrna-135a-regulates-sodium-calcium-exchanger-gene-expression-and-cardiac-electrical-activity
#13
Eric Duong, Jiening Xiao, Xiao Yan Qi, Stanley Nattel
BACKGROUND: Complete atrioventricular block (CAVB) causes arrhythmogenic remodeling and increases the risk of Torsades de Pointes (TdP) arrhythmias. MicroRNAs (miRNAs) are key regulators of gene-expression that contribute to cardiac remodeling. OBJECTIVE: To assess miRNA changes after complete atrioventricular block (CAVB) and identify novel candidates potentially involved in arrhythmogenic cardiac remodeling. METHODS: CAVB was induced in mice via His bundle ablation...
February 7, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28187518/male-caffeine-and-alcohol-intake-in-relation-to-semen-parameters-and-in%C3%A2-vitro-fertilization-outcomes-among-fertility-patients
#14
A E Karmon, T L Toth, Y-H Chiu, A J Gaskins, C Tanrikut, D L Wright, R Hauser, J E Chavarro
Much of the literature on the impact of male caffeine and alcohol intake on reproductive outcomes has utilized semen quality as a proxy for male fertility, although semen parameters have a limited predictive value for spontaneous pregnancy. The objective of this study was to investigate whether male caffeine and alcohol intakes are associated with semen parameters and assisted reproductive technology outcome. The Environment and Reproductive Health Study, an ongoing prospective cohort study, enrolls subfertile couples presenting for treatment at an academic fertility center (2007-2012)...
February 10, 2017: Andrology
https://www.readbyqxmd.com/read/28182503/do-glucose-and-caffeine-nasal-sprays-influence-exercise-and-or-cognitive-performance
#15
Kevin De Pauw, Bart Roelands, Jeroen Van Cutsem, Lieselot Decroix, Angelica Valente, Kim Taehee, Robert B LettanII, Andres E Carrillo, Romain Meeusen
INTRODUCTION/PURPOSE: Since nasal sprays (NAS) containing caffeine (CAF) or glucose (GLUC) activate sensory(motor) cortices, the aim of this study was to investigate the influence of CAF or GLUC-NAS on exercise and cognitive performance. METHODS: Eleven male subjects (Age: 22±2 yrs) performed a maximal cycle test, two familiarization and three experimental trials. Each trial included a 30 s Wingate test and a 30 min time-trial (TT) performance test interspersed by 15 min of rest...
February 9, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28179084/corrigendum-to-influence-of-caffeine-on-the-protective-activity-of-gabapentin-and-topiramate-in-a-mouse-model-of-generalized-tonic-clonic-seizures-pharmacol-rep-68-2016-680-685
#16
Małgorzata Jargiełło-Baszak, Magdalena Chrościńska-Krawczyk, Marta Andres-Mach, Jarogniew J Łuszczki, Stanisław J Czuczwar
No abstract text is available yet for this article.
February 5, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28178090/management-of-a-ventral-cerebrospinal-fluid-leak-with-a-lumbar-transforaminal-epidural-blood-patch-in-a-child-with-persistent-postdural-puncture-headache-a-case-report
#17
Genevieve Dʼsouza, F Glen Seidel, Elliot J Krane
OBJECTIVE: Postdural puncture headache (PDPH) is an uncommon sequel of lumbar puncture in children. When conservative treatment with bed rest, hydration, and caffeine are ineffective, epidural blood patches are recommended and are generally effective. The purpose of this report was to highlight that when lumbar epidural blood patches fail to eliminate PDPH, diagnostic evaluation should be performed and alternative treatment sought. CASE REPORT: An unusual case is described of an 11-year-old boy with PDPH, which was successfully managed with a ventral (anterior) epidural blood patch and epidural saline infusion after headache and other symptoms failed to resolve after conservative treatment and conventionally performed blood patches...
March 2017: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/28177708/the-effect-of-caffeine-on-skeletal-muscle-anabolic-signaling-and-hypertrophy
#18
Timothy M Moore, Xavier M Mortensen, Conrad K Ashby, Alexander M Harris, Karson J Kump, David W Laird, Aaron J Adams, Jeremy K Bray, Ting Chen, David M Thomson
Caffeine is a widely-consumed stimulant with the potential to enhance physical performance through multiple mechanisms. However, recent in vitro findings have suggested that caffeine may block skeletal muscle anabolic signaling through AMP-activated protein kinase (AMPK)-mediated inhibition of mechanistic target of rapamycin (mTOR) signaling pathway. This could negatively affect protein synthesis and the capacity for muscle growth. The primary purpose of this study was to assess the effect of caffeine on in vivo AMPK and mTOR pathway signaling, protein synthesis and muscle growth...
January 26, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28177707/dietary-fish-oil-delays-hypoxic-skeletal-muscle-fatigue-and-enhances-caffeine-stimulated-contractile-recovery-in-the-rat-in-vivo-hindlimb
#19
Gregory E Peoples, Peter L McLennan
Oxygen efficiency influences skeletal muscle contractile function during physiological hypoxia. Dietary fish oil, providing docosahexaenoic acid (DHA), reduces the oxygen cost of muscle contraction. This study used autologous perfused rat hindlimb model to examine the effects of a fish oil diet on skeletal muscle fatigue during an acute hypoxic challenge. Male Wistar rats were fed a diet rich in saturated fat (SF), long chain (LC) n-6 polyunsaturated fatty acids (n-6 PUFA), or LC n-3 PUFA DHA from fish oil (FO) (8weeks)...
January 26, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28177691/caffeine-intake-increases-plasma-ketones-an-acute-metabolic-study-in-humans
#20
Camille Vandenberghe, Valerie St-Pierre, Alexandre Courchesne-Loyer, Marie Hennebelle, Christian-Alexandre Castellano, Stephen C Cunnane
Brain glucose uptake declines during aging and is significantly impaired in Alzheimer's disease. Ketones are the main alternative brain fuel to glucose so they represent a potential approach to compensate for the brain glucose reduction. Caffeine is of interest as a potential ketogenic agent owing to its actions on lipolysis/ lipid oxidation but whether it is ketogenic in humans is unknown. This study aimed to evaluate the acute ketogenic effect of two doses of caffeine in healthy adults (2.5; 5.0 mg/kg) during a 4-hour metabolic study period...
November 25, 2016: Canadian Journal of Physiology and Pharmacology
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