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Ryan D Madder, Stacie VanOosterhout, David Klungle, Abbey Mulder, Matthew Elmore, Jeffrey M Decker, David Langholz, Thomas F Boyden, Jessica Parker, James E Muller
BACKGROUND: This study sought to determine the frequency of large lipid-rich plaques (LRP) in the coronary arteries of individuals with high coronary artery calcium scores (CACS) and to determine whether the CACS correlates with coronary lipid burden. METHODS AND RESULTS: Combined near-infrared spectroscopy and intravascular ultrasound was performed in 57 vessels in 20 asymptomatic individuals (90% on statins) with no prior history of coronary artery disease who had a screening CACS ≥300 Agatston units...
October 2017: Circulation. Cardiovascular Imaging
Georgios E Christakopoulos, Judit Karacsonyi, Barbara Anna Danek, Aris Karatasakis, Aya Alame, Pratik Kalsaria, Atif Mohammed, Michele Roesle, Bavana V Rangan, Subhash Banerjee, Emmanouil S Brilakis
OBJECTIVE: To examine the presence and localization of lipid-core plaque (LCP) in coronary vessels with chronic total occlusions (CTOs) using near-infrared spectroscopy (NIRS). METHODS: NIRS imaging was performed after guidewire crossing of the occlusion in 15 patients with CTOs. LCP was defined as ≥2 adjacent 2 mm yellow blocks on the block chemogram. We also measured the maximum lipid-core burden index (LCBI) in a 4 mm length of artery (maxLCBI4mm). Large LCP was defined as maxLCBI4mm ≥500...
December 2016: Journal of Invasive Cardiology
Irina Franke, Sarah Thier, Anita Riecher-Rössler
BACKGROUND: Adherence to evidence-based guidelines is essential for the treatment outcome of psychotic disorders. Previous studies showed that IT-supported pathways are able to increase guideline adherence in psychiatric care. This paper describes a pilot study on the development of an electronic recall-reminder-system (RRS) for supporting guideline-adherent treatment in outpatient care of patients with chronic psychotic disorders and analyses its feasibility. METHODS: Guidelines were integrated in the RRS software M...
December 2016: Neuropsychiatrie: Klinik, Diagnostik, Therapie und Rehabilitation
Elżbieta Pociask, Joanna Jaworek-Korjakowska, Krzysztof Piotr Malinowski, Tomasz Roleder, Wojciech Wojakowski
Background. Detecting and identifying vulnerable plaque, which is prone to rupture, is still a challenge for cardiologist. Such lipid core-containing plaque is still not identifiable by everyday angiography, thus triggering the need to develop a new tool where NIRS-IVUS can visualize plaque characterization in terms of its chemical and morphologic characteristic. The new tool can lead to the development of new methods of interpreting the newly obtained data. In this study, the algorithm to fully automated lipid pool detection on NIRS images is proposed...
2016: Computational and Mathematical Methods in Medicine
Barbara A Danek, Aris Karatasakis, Aya J Alame, Phuong-Khanh J Nguyen-Trong, Judit Karacsonyi, Bavana Rangan, Michele Roesle, Amy Atwell, Erica Resendes, Jose Roberto Martinez-Parachini, Rahel Iwnetu, Pratik Kalsaria, Furqan Siddiqui, James E Muller, Subhash Banerjee, Emmanouil Brilakis
OBJECTIVES: We sought to examine near-infrared spectroscopy (NIRS) imaging findings of aortocoronary saphenous vein grafts (SVGs). BACKGROUND: SVGs are prone to develop atherosclerosis similar to native coronary arteries. They have received little study using NIRS. METHODS: We examined the clinical characteristics and imaging findings from 43 patients who underwent NIRS imaging of 45 SVGs at our institution between 2009 and 2016. RESULTS: The mean patient age was 67 ± 7 years and 98% were men, with high prevalence of diabetes mellitus (56%), hypertension (95%), and dyslipidemia (95%)...
May 2017: Catheterization and Cardiovascular Interventions
Pauline Duconseil, Marine Gilabert, Odile Gayet, Celine Loncle, Vincent Moutardier, Olivier Turrini, Ezequiel Calvo, Jacques Ewald, Marc Giovannini, Mohamed Gasmi, Erwan Bories, Marc Barthet, Mehdi Ouaissi, Anthony Goncalves, Flora Poizat, Jean Luc Raoul, Veronique Secq, Stephane Garcia, Patrice Viens, Juan Iovanna, Nelson Dusetti
A major impediment to the effective treatment of patients with pancreatic ductal adenocarcinoma (PDAC) is the molecular heterogeneity of this disease, which is reflected in an equally diverse pattern of clinical outcome and in responses to therapies. We developed an efficient strategy in which PDAC samples from 17 consecutive patients were collected by endoscopic ultrasound-guided fine-needle aspiration or surgery and were preserved as breathing tumors by xenografting and as a primary culture of epithelial cells...
April 2015: American Journal of Pathology
Soo-Jin Kang, Gary S Mintz, Jun Pu, Stephen T Sum, Sean P Madden, Allen P Burke, Ke Xu, James A Goldstein, Gregg W Stone, James E Muller, Renu Virmani, Akiko Maehara
OBJECTIVES: This study assessed grayscale intravascular ultrasound (IVUS) and near-infrared spectroscopy (NIRS) detection of a histological fibroatheroma (FA). BACKGROUND: NIRS-detected, lipid-rich plaques (LRPs) and IVUS-detected attenuated plaques are considered to be vulnerable. METHODS: IVUS-attenuated plaque and NIRS-LRP (yellow or tan block chemogram) were compared with histopathology in 1,943 sections of 103 coronary arteries from 56 autopsied hearts...
February 2015: JACC. Cardiovascular Imaging
David Erlinge, Jan Harnek, Isabel Gonçalves, Matthias Götberg, James E Muller, Ryan D Madder
AIMS: Intracoronary near-infrared spectroscopy (NIRS) in ST-segment elevation myocardial infarction (STEMI) has demonstrated substantial lipid in STEMI culprit plaques. Thrombus aspiration during primary PCI reduces distal embolization and improves reperfusion. This study was performed to examine if aspiration thrombectomy reduces the lipid content of acute coronary syndrome (ACS) culprit plaques. METHODS AND RESULTS: NIRS-IVUS imaging was performed in patients with an ACS at two hospitals in the US and Sweden...
March 2015: European Heart Journal Cardiovascular Imaging
Tomáš Ondrúš, Jan Kaňovský, Martin Poloczek, Roman Miklík, Otakar Boček, Petr Jeřábek, Petr Kala
Acute coronary syndrome may develop in the background of hemodynamically non-significant coronary artery disease. It may be caused by the presence of "vulnerable plaque", which is characterized by the lipid rich core and thin fibrous cap content. NIRS - near infrared spectroscopy - is a morphological imaging method allowing determining atherosclerotic plaque cholesterol burden. Information about the chemical composition may contribute to "high risk" plaque early identification and subsequent optimal interventional strategy...
May 2014: Vnitr̆ní Lékar̆ství
Milosz Jaguszewski, Roland Klingenberg, Ulf Landmesser
Acute coronary syndromes are frequently caused by "vulnerable" coronary plaques with a lipid-rich core. In 1993 near-infrared spectroscopy (NIRS) was first used to detect the lipid (cholesterol) content of atherosclerotic plaques in an experimental animal study. NIRS was then carefully validated using human atherosclerotic plaques (ex vivo), and has subsequently been developed for intracoronary imaging in humans, for which now an FDA-approved catheter-based NIRS system is available. NIRS provides a "chemogram" of the coronary artery wall and is used to detect lipid-rich plaques...
2013: Current Cardiovascular Imaging Reports
Taishi Yonetsu, William Suh, Farhad Abtahian, Koji Kato, Rocco Vergallo, Soo-Joong Kim, Haibo Jia, Iris McNulty, Hang Lee, Ik-Kyung Jang
OBJECTIVES: To compare intracoronary near-infrared spectroscopy (NIRS) and optical coherence tomography (OCT) for the detection of lipid, to identify NIRS signals to differentiate superficial lipid, and to characterize the plaque with yellow block (YB) chemograms on NIRS. BACKGROUND: Intracoronary NIRS has been developed to detect lipid core plaque (LCP). METHODS: We investigated a total of 17 patients who underwent both OCT and NIRS. NIRS analysis included plaque lipid core burden index (LCBI), LCP length, and the presence of YB on the block chemogram...
November 1, 2014: Catheterization and Cardiovascular Interventions
Achuta K Guddati, Shagufta Shaheen
INTRODUCTION: Ovarian cancer is one of the leading causes of death in women with cancer. First-line chemotherapy with platinum compounds and taxane compounds has been effective, but most patients develop a relapse of the disease due to drug resistance. There is growing evidence that this resistance may be due to the presence of ovarian cancer stem cells. DISCUSSION: Cells with properties of cancer stem cells have been isolated from the ascitic fluid of ovarian cancer patients...
June 2013: Journal of Chemotherapy
Byoung-Joo Choi, Abhiram Prasad, Rajiv Gulati, Patricia J Best, Ryan J Lennon, Gregory W Barsness, Lilach O Lerman, Amir Lerman
AIMS: Endothelial dysfunction is considered to play a key role in the development of atherosclerosis. However, only a limited number of human imaging studies have been available to demonstrate this hypothesis. The present study used near-infrared spectroscopy (NIRS) to investigate whether coronary endothelial dysfunction is associated with the lipid core plaque (LCP) in patients with early coronary artery disease. METHODS AND RESULTS: A total of 32 patients with chest pain who had diameter stenosis <30% were enrolled...
July 2013: European Heart Journal
Ryan D Madder, James L Smith, Simon R Dixon, James A Goldstein
BACKGROUND: Whereas acute coronary syndromes (ACS) typically develop from the rupture of lipid core plaque (LCP), lesions causing stable angina are believed to be composed of fibrocalcific plaque. In this study, intracoronary near-infrared spectroscopy (NIRS) was used to determine the frequency of LCP at target and remote sites in patients with ACS versus those with stable angina. METHODS AND RESULTS: The study was performed in patients having ≥1 target lesion identified by invasive angiography who also underwent NIRS before intervention...
February 1, 2012: Circulation. Cardiovascular Interventions
Aristotelis C Papayannis, Abdul-Rahman R Abdel-Karim, Arif Mahmood, Bavana V Rangan, Lorenza B Makke, Subhash Banerjee, Emmanouil S Brilakis
BACKGROUND: Optical coherence tomography (OCT) and near-infrared spectroscopy (NIRS) allow assessment of the anatomy (OCT) and composition (NIRS) of coronary lesions. We sought to examine the association between pre-stenting lipid core plaque (LCP), as assessed by NIRS and post-stenting thrombus formation, as assessed by OCT. METHODS: We reviewed the angiograms of nine patients who underwent coronary stenting in association with NIRS and OCT imaging. A large LCP by NIRS was defined as at least three 2-mm yellow blocks on the NIRS block chemogram with >200° angular extent...
February 2013: Catheterization and Cardiovascular Interventions
Simon R Dixon, Cindy L Grines, Ahmad Munir, Ryan D Madder, Robert D Safian, George S Hanzel, Mark C Pica, James A Goldstein
Lipid core plaque (LCP) can extend beyond the angiographic margins of a target lesion, potentially resulting in incomplete lesion coverage. We sought to compare the target lesion length using near-infrared spectroscopy (NIRS) combined with conventional coronary angiography versus angiography alone. NIRS was performed in 69 patients (75 lesions) undergoing native vessel percutaneous coronary intervention (LipiScan Coronary Imaging System). Chemograms were analyzed for the presence and location of LCP, either within or extending beyond, the angiographic margins of the target lesion...
January 1, 2012: American Journal of Cardiology
Salvatore Brugaletta, Hector M Garcia-Garcia, Patrick W Serruys, Sanneke de Boer, Jurgen Ligthart, Josep Gomez-Lara, Karen Witberg, Roberto Diletti, Joanna Wykrzykowska, Robert-Jan van Geuns, Carl Schultz, Evelyn Regar, Henricus J Duckers, Nicolas van Mieghem, Peter de Jaegere, Sean P Madden, James E Muller, Antonius F W van der Steen, Wim J van der Giessen, Eric Boersma
OBJECTIVES: The aim of this study was to compare the findings of near-infrared spectroscopy (NIRS), intravascular ultrasound (IVUS) virtual histology (VH), and grayscale IVUS obtained in matched coronary vessel segments of patients undergoing coronary angiography. BACKGROUND: Intravascular ultrasound VH has been developed to add tissue characterization to the grayscale IVUS assessment of coronary plaques. Near-infrared spectroscopy is a new imaging technique able to identify lipid core-containing coronary plaques (LCP)...
June 2011: JACC. Cardiovascular Imaging
Deepa Raghunathan, Abdul-Rahman Riyad Abdel-Karim, Aristotelis C Papayannis, Monica daSilva, Omar M Jeroudi, Bavana V Rangan, Subhash Banerjee, Emmanouil S Brilakis
We aimed to examine whether an association exists between the presence and extent of coronary lipid core plaques (LCPs) detected by near-infrared spectroscopy (NIRS) performed before percutaneous coronary intervention (PCI) with postprocedural myocardial infarction (MI). NIRS was performed in the native coronary arteries of 30 patients before PCI. Angular extent of LCP, lesion segment lipid core burden index, and block chemogram were evaluated. Cardiac biomarkers were measured before and 16 to 24 hours after PCI to determine occurrence of postprocedural MI...
June 1, 2011: American Journal of Cardiology
G Riou, J Benard
Tumoral stem cells capable of multiplying can be selected from human tumours by in vitro culture techniques. These are the cells which renew the tumour and form metastases. Placed in a suitable agar medium, they give birth to cellular clones. The selection of clone-forming cells from human tumours makes it possible to devise chemograms, as has successfully been done in the U.S.A. by the Salmon and von Hoff teams. Working on a fairly large number of different cancers and using in vitro tests in the presence of drugs, these scientists were able to predict chemosensitivity and chemoresistance in 62 to 96% of tumours...
December 5, 1981: La Nouvelle Presse Médicale
J Bénard, G Riou
One hundred and thirty three specimens from mammary and ovarian adenocarcinoma and from melanoma were cultured according to an agar/agar clonogenic assay. Melanoma and ovarian cancers exhibited a 70 per cent rate of success for culture; 50 per cent of the mammary adenocarcinomas were successfully cultured. Fifty-nine ovarian cancers were cultured in order to test the in vitro effectiveness of Cisplatinum and Adriamycin. Thirty percent of cultured tumors gave rise to relevant chemograms. The chemoresistance measured in vitro was correlated to the ineffectiveness of the patient's treatment...
1984: Bulletin du Cancer
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