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Isadora Argou-Cardozo, Fares Zeidán-Chuliá
Nowadays, there seems to be a consensus about the multifactorial nature of autism spectrum disorders (ASD). The literature provides hypotheses dealing with numerous environmental factors and genes accounting for the apparently higher prevalence of this condition. Researchers have shown evidence regarding the impact of gut bacteria on neurological outcomes, altering behavior and potentially affecting the onset and/or severity of psychiatric disorders. Pesticides and agrotoxics are also included among this long list of ASD-related environmental stressors...
April 4, 2018: Medical Sciences: Open Access Journal
Rafaela M Moresco, Vladimir P Margarido, Classius de Oliveira
Representing a reflection of anthropic activity, the level of xenobiotic compounds in aquatic ecosystems has increased in recent years, bringing severe damage to the environment. The present work reports the occurrence of malformation in gonads of Physalaemus cuvieri individuals from a population of Atlantic Forest in Southern Brazil. Twenty male specimens were collected, which had their testicles removed, immersed in Karnovsky fixative solution, included in historesin for 2 μm cuts and stained with Hematoxylin-eosin...
July 2014: Environmental Research
Daiane Körbes, Aron Ferreira da Silveira, Miguel Angelo Hyppolito, Gisiane Munaro
UNLABELLED: Organophosphate toxic agents are used in agriculture and are currently part of the group of toxic agents which can lead to hearing loss, in which we have solvents, metals and asphyxiation agents. AIM: To analyze the acute ototoxic action of a group of organophosphate agents in the vestibulo-cochlear system. This is a prospective experimental study. MATERIALS AND METHODS: We used male albino guinea pigs, broken down into three groups, to which we provided distilled water (group 1 - control), agrotoxic agent - 0...
March 2010: Brazilian Journal of Otorhinolaryngology
Paulo Fernandes Costa Jobim, Luciana Neves Nunes, Roberto Giugliani, Ivana Beatrice Manica da Cruz
The chronic use of agrotoxics in rural regions of Rio Grande do Sul State (RS) has been tentatively associated to a possible increase in the incidence of cancer in rural areas. A time-trend ecological study was performed in the micro region of Ijuí County (MI), in RS and Brazil, with data of the 1979 to 2003 period. Data was collected from the Mortality Information System, Brazilian Ministry of Health (DATASUS), to evaluate the cancer mortality rate, standardized by gender and age - corrected mortality ratios...
January 2010: Ciência & Saúde Coletiva
P Poli, M A de Mello, A Buschini, V L S S de Castro, F M Restivo, C Rossi, T M A D Zucchi
Fenarimol, a systemic pyrimidine carbinol fungicide, is considered to be not genotoxic or weakly genotoxic, although the available toxicological data are controversial and incomplete. Our results obtained in vitro with leukocytes of two different rodent species (rat and mouse) show that fenarimol affects DNA, as detected by the single-cell gel electrophoresis (SCGE, Comet) assay. This fungicide is able to induce DNA damage in a dose-related manner, with significant effectiveness at 36 nM, but without significant interspecies differences...
September 9, 2003: Mutation Research
M H De Souza, A R Pires, H R Diamond
Thirty-one patients (pts) with aplastic anaemia (AA) were studied whose probable etiology were: idiopathic (16 pts), nocturnal aroxysmal haemoglobinuria (NPH) (2 pts), benzene (4 pts), agrotoxics (5 pts), pharmaceutical drugs (2 pts) and insecticides (2 pts). A decrease in total lymphocyte counts was seen in 10 pts belonging mainly to the NPH and pharmaceutical drug groups, whereas, in the benzene group the opposite was found. B cell levels were low in 9 out of 20 pts. T cell levels varied, the majority of patients had normal levels, 13 presented low levels and 4 had increased numbers...
November 1989: Journal of Clinical & Laboratory Immunology
A M Bueno, J M Agostini, K Gaidzinski, J Moreira, I Brognoli
The present work has been accomplished in the basin of the Sangão River (Criciúma, South Brazil), which receives the rejects from coal washing, mainly heavy metals. In the tobacco cultures at the river banks several agrotoxics are used. We tried to detect and estimate the possible action of this environmental pollution on rodents directly exposed to it through the study of chromosome aberration frequency in the bone marrow. The same methodology was applied to rodents collected from a nonpolluted area of the same state (Florianópolis, 190 km from Criciúma)...
June 1992: Journal of Toxicology and Environmental Health
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