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https://www.readbyqxmd.com/read/28655174/diagnosis-and-management-of-osteopetrosis-consensus-guidelines-from-the-osteopetrosis-working-group
#1
Calvin C Wu, Michael J Econs, Linda A DiMeglio, Karl L Insogna, Michael A Levine, Paul J Orchard, Weston P Miller, Anna Petryk, Eric T Rush, Dolores M Shoback, Leanne M Ward, Lynda E Polgreen
Background: Osteopetrosis encompasses a group of rare metabolic bone diseases characterized by impaired osteoclast activity or development, resulting in high bone mineral density. Existing guidelines focus on treatment of the severe infantile forms with hematopoietic cell transplantation (HCT), but do not address the management of patients with less severe forms for whom HCT is not the standard of care. Therefore, our objective was to develop expert consensus guidelines that would address the management of these patients...
June 26, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28655115/characteristics-and-fate-of-natural-organic-matter-during-uv-oxidation-processes
#2
Yongtae Ahn, Doorae Lee, Minhwan Kwon, Il-Hwan Choi, Seong-Nam Nam, Joon-Wun Kang
Advanced oxidation processes (AOPs) are widely used in water treatments. During oxidation processes, natural organic matter (NOM) is modified and broken down into smaller compounds that affect the characteristics of the oxidized NOM by AOPs. In this study, NOM was characterized and monitored in the UV/hydrogen peroxide (H2O2) and UV/persulfate (PS) processes using a liquid chromatography-organic carbon detector (LC-OCD) technique, and a combination of excitation-emission matrices (EEM) and parallel factor analysis (PARAFAC)...
June 19, 2017: Chemosphere
https://www.readbyqxmd.com/read/28655072/oral-administration-of-glycine-and-leucine-dipeptides-improves-skin-hydration-and-elasticity-in-uvb-irradiated-hairless-mice
#3
Jong Il Park, Ji Eun Lee, Hyun Jun Shin, Soonran Song, Won Kyung Lee, Jae Sung Hwang
Placenta is a special organ that contains many nutrients such as growth factors, minerals, and bioactive peptides. Dipeptides of glycine and leucine are major components of porcine placenta extracts (PPE) that has been used as an alternative of human placenta extracts. In this study, we investigated whether major peptides of PPE, Glycyl-L-Leucine (Gly-Leu), L-Leucyl-Glycine (Leu-Gly), and L-Leucyl-L-Leucine (Leu-Leu), affect skin hydration and elasticity in vitro and in vivo. We found that Gly-Leu and Leu-Gly dipeptides induced the expression of transglutaminase 1 in normal human epidermal keratinocytes (NHEKs) whereas Leu-Leu dipeptides did not...
June 27, 2017: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/28654805/role-of-root-exudates-in-metal-acquisition-and-tolerance
#4
REVIEW
Yi-Tze Chen, Ying Wang, Kuo-Chen Yeh
Plants acquire mineral nutrients mostly through the rhizosphere; they secrete a large number of metabolites into the rhizosphere to regulate nutrient availability and to detoxify undesirable metal pollutants in soils. The secreted metabolites are inorganic ions, gaseous molecules, and mainly carbon-based compounds. This review focuses on the mechanisms and regulation of low-molecular-weight organic-compound exudation in terms of metal acquisition. We summarize findings on riboflavin/phenolic-facilitated and phytosiderophore-facilitated iron acquisition and discuss recent studies of the functions and secretion mechanisms of low-molecular-weight organic acids in heavy-metal detoxification...
June 24, 2017: Current Opinion in Plant Biology
https://www.readbyqxmd.com/read/28654803/photo-assisted-electrochemical-degradation-of-sulfamethoxazole-using-a-ti-ru0-3ti0-7o2-anode-mechanistic-and-kinetic-features-of-the-process
#5
Sajjad Hussain, Juliana R Steter, Saima Gul, Artur J Motheo
This study examined the photo-assisted electrochemical degradation and mineralization of the antibiotic contaminant sulfamethoxazole (SMX). All the experiments were perform using a flow electrolytic cell, in which the influence of the current density (10-60 mA cm(-2)) and sodium chloride (0.02-0.10 mol L(-1)) in the supporting electrolyte composition was analyzed. The results showed that the total SMX and 50% TOC removal was achieved in the current density range used. As expected, the degradation kinetics presented a pseudo first order behavior and the rate constant increased from 0...
June 24, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28654787/remediation-of-soils-polluted-with-lindane-using-surfactant-aided-soil-washing-and-electrochemical-oxidation
#6
M Muñoz-Morales, M Braojos, C Sáez, P Cañizares, M A Rodrigo
In this work the complete treatment of soil spiked with lindane is studied using surfactant-aided soil-washing (SASW) to exhaust lindane from soil and electrolysis with diamond anodes to mineralize lindane from the soil washing fluid (SWF) waste. Results demonstrated that this technological approach is efficient and allow to remove this hazardous pollutant from soil. They also pointed out the significance of the ratio surfactant/soil in the efficiency of the SASW process and in the performance of the later electrolysis used to mineralize the pollutant...
June 17, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28654689/a-high-density-intraspecific-snp-linkage-map-of-pigeonpea-cajanas-cajan-l-millsp
#7
Sheetal Arora, Ajay Kumar Mahato, Sangeeta Singh, Paritra Mandal, Shefali Bhutani, Sutapa Dutta, Giriraj Kumawat, Bikram Pratap Singh, A K Chaudhary, Rekha Yadav, K Gaikwad, Amitha Mithra Sevanthi, Subhojit Datta, Ranjeet S Raje, Tilak R Sharma, Nagendra Kumar Singh
Pigeonpea (Cajanus cajan (L.) Millsp.) is a major food legume cultivated in semi-arid tropical regions including the Indian subcontinent, Africa, and Southeast Asia. It is an important source of protein, minerals, and vitamins for nearly 20% of the world population. Due to high carbon sequestration and drought tolerance, pigeonpea is an important crop for the development of climate resilient agriculture and nutritional security. However, pigeonpea productivity has remained low for decades because of limited genetic and genomic resources, and sparse utilization of landraces and wild pigeonpea germplasm...
2017: PloS One
https://www.readbyqxmd.com/read/28653837/quantifying-reactive-transport-processes-governing-arsenic-mobility-after-injection-of-reactive-organic-carbon-into-a-bengal-bay-aquifer
#8
Joey Rawson, Adam Siade, Jing Sun, Harald Neidhardt, Michael Berg, Henning Prommer
Over the last few decades, significant progress has been made to characterize the extent, severity, and underlying geochemical processes of groundwater arsenic (As) pollution in S/SE Asia. However, comparably little effort has been made to merge the findings into frameworks that allow for a process-based quantitative analysis of observed As behavior and for predictions of its long-term fate. This study developed field-scale numerical modeling approaches to represent the hydrochemical processes associated with an in situ field injection of reactive organic carbon, including the reductive dissolution and transformation of ferric iron (Fe) oxides and the concomitant release of sorbed As...
June 27, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28653756/a-zinc-oxide-modified-hydroxyapatite-based-cement-facilitated-new-crystalline-stoichiometric-and-amorphous-apatite-precipitation-on-dentine
#9
M Toledano, M C Pérez-Álvarez, F S Aguilera, E Osorio, I Cabello, M Toledano-Osorio, R Osorio
AIM: To evaluate the remineralization ability of two endodontic sealer cements. METHODOLOGY: Mid-coronal dentine surfaces were subjected to: i) 37% phosphoric acid (PA) or ii) 0.5 M ethylenediaminetetraacetic acid (EDTA) conditioning prior to the application of two experimental hydroxyapatite-based cements, containing sodium hydroxide (calcypatite) or zinc oxide (oxipatite), respectively. Samples were stored in simulated body fluid for 24 h or 21 d. Remineralization of the dentine surfaces were studied by Raman spectroscopy (mapping with K-means cluster and hierarchical cluster analysis) was undertaken were done...
June 27, 2017: International Endodontic Journal
https://www.readbyqxmd.com/read/28653735/unavoidable-food-supply-chain-waste-acid-free-pectin-extraction-from-mango-peel-via-subcritical-water
#10
H Xia, A S Matharu
Mango peel is the major by-product of mango processing, and compromises 7-24% of the total mango weight. In this study, pectin was extracted from mango peel waste by using subcritical water extraction (SWE) in the absence of mineral acid. A highest yield of 18.34% was achieved from the Kesar variety and the pectin was characterised using ATR-IR spectroscopy, TGA and (13)C solid-state NMR spectroscopy to confirm the structure. The degree of esterification (DE) of the pectin was analysed with both titrimetry and (13)C solid-state NMR spectroscopy, and a high DE (>70%) was observed for all three varieties (Keitt, Sindhri and Kesar)...
June 27, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/28653616/head-to-head-comparisons-of-bisphosphonates-and-teriparatide-in-osteoporosis-a-meta-analysis
#11
Chun-Lin Liu, Han-Chung Lee, Chun-Chung Chen, Der-Yang Cho
PURPOSE: This meta-analysis aimed to compare the efficacy and safety of teriparatide vs. bisphosphonates in the management of osteoporosis. METHODS: A total of 1,967 patients from eight randomized controlled trials were analyzed; outcomes included bone mineral density (BMD) of the femoral neck, total hip and lumbar spine, vertebral and nonvertebral fractures and any adverse event. A subgroup analysis of treatment effectiveness was performed according to the etiology of osteoporosis; i...
June 26, 2017: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://www.readbyqxmd.com/read/28653343/guided-bone-regeneration-at-zirconia-and-titanium-dental-implants-a-pilot-histological-investigation
#12
Goran I Benic, Daniel S Thoma, Ignacio Sanz-Martin, Fernando Munoz, Christoph H F Hämmerle, Antonio Cantalapiedra, Jens Fischer, Ronald E Jung
AIM: To test whether guided bone regeneration (GBR) of peri-implant defects at zirconia (ZrO2 ) implants differs from GBR at titanium (Ti) implants regarding the bone integration of the implant and of the grafting material. MATERIALS AND METHODS: Maxillary premolars and molars were extracted in seven dogs. After 5 months, four semi-saddle bone defects were created in each maxilla. Implant placement and simultaneous GBR were performed using the following randomly assigned modalities: (1) ZrO2 implant + deproteinized bovine bone mineral (DBBM) granules + a collagen membrane (CM), (2) ZrO2 implant + DBBM with 10% collagen matrix + CM, (3) ZrO2 implant + DBBM block + CM, and (4) Ti implant + DBBM granules + CM...
June 26, 2017: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/28653337/hardystonite-coated-poly-l-lactide-nanofibrous-scaffold-and-efficient-osteogenic-differentiation-of-adipose-derived-mesenchymal-stem-cells
#13
Banafsheh Tavangar, Shaghayegh Arasteh, Haleh Edalatkhah, Ali Salimi, Ali Doostmohammadi, Ehsan Seyedjafari
In this study, a ceramic-coated nanofibrous scaffold has been fabricated to biomimic the microstructure of natural extracellular matrix and the stiffening inorganic compartment of bone. Poly-l-lactic acid (PLLA) nanofibers were electrospun and exposed to oxygen plasma to induce hydrophilicity and promote ceramic adsorption. Hardystonite (HS), which possesses superior osteoinduction potential over hydroxyapatite, was coated on plasma-treated PLLA nanofibers by drenching the nanofibers in HS suspension. Pure and composite PLLA-based scaffolds were characterized in terms of physical and biological properties...
June 27, 2017: Artificial Organs
https://www.readbyqxmd.com/read/28652893/low-bone-mineral-density-and-the-severity-of-cholestasis-in-biliary-atresia
#14
Krittapak Homchan, Tawatchai Chaiwatanarat, Wanvisa Udomsinprasert, Voranush Chongsrisawat, Yong Poovorawan, Sittisak Honsawek
AIM: To investigate the prevalence of osteopenia and osteoporosis in postoperative biliary atresia (BA) children and the association of bone mineral density (BMD) and biochemical parameters in postKasai BA subjects. METHODS: A total of 70 patients with postKasai BA were enrolled in this prospective study. The patients were classified into two groups according to their jaundice status. BMD of the lumbar spine was analyzed using dual energy X-ray absorptiometry. RESULTS: The prevalence of low bone mass (osteopenia and osteoporosis) in BA patients were 51...
June 8, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28652800/nutritional-status-among-peritoneal-dialysis-patients-after-oral-supplement-with-once-dialyze-formula
#15
Bancha Satirapoj, Pokkrong Limwannata, Chadarat Kleebchaiyaphum, Janjira Prapakorn, Ussanee Yatinan, Samitti Chotsriluecha, Ouppatham Supasyndh
BACKGROUND: Malnutrition is an important problem in patients treated with long-term dialysis, and most dialysis patients have lower dietary energy and protein intake. This study was undertaken to examine whether orally administered Otsuka Nutrition Pharmaceutical (ONCE) dialyze formula (ODF) supplement would improve energy intake without mineral and electrolyte disturbances in patients with continuous ambulatory peritoneal dialysis (CAPD). METHODS: The effects of ODF supplementation on nutrition markers including serum albumin and prealbumin concentrations and inflammatory stress in patients with chronic CAPD were evaluated...
2017: International Journal of Nephrology and Renovascular Disease
https://www.readbyqxmd.com/read/28652188/streptozocin-induced-type-1-diabetes-mellitus-results-in-decreased-density-of-cgrp-sensory-and-th-sympathetic-nerve-fibers-that-are-positively-correlated-with-bone-loss-at-the-mouse-femoral-neck
#16
Iris Abigail Enríquez Pérez, Karla Estefanía Galindo Ordoñez, Christian Emanuel Pantoja Ortiz, Arisai Martínez, Rosa Issel Acosta González, Enriqueta Muñoz Islas, Juan Miguel Jiménez Andrade
Type-1 diabetes mellitus (T1DM) results in loss of innervation in some tissues including epidermis and retina; however, the effect on bone innervation is unknown. Likewise, T1DM results in pathological bone loss and increased risk of fracture. Thus, we quantified the density of calcitonin gene-related peptide (CGRP(+)) sensory and tyrosine hydroxylase (TH(+)) sympathetic nerve fibers and determined the association between the innervation density and microarchitecture of trabecular bone at the mouse femoral neck...
June 23, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28652107/plasma-ppi-deficiency-is-the-major-but-not-the-exclusive-cause-of-ectopic-mineralization-in-an-abcc6-mouse-model-of-pxe
#17
Jingyi Zhao, Joshua Kingman, John P Sundberg, Jouni Uitto, Qiaoli Li
Pseudoxanthoma elasticum (PXE), a prototype of heritable ectopic mineralization disorders, is caused in most cases by inactivating mutations in the ABCC6 gene. It was recently discovered that absence of ABCC6-mediated ATP release from the liver and consequently reduced plasma PPi levels underlie PXE. This study examined whether reduced levels of circulating PPi, an anti-mineralization factor, is the sole mechanism of PXE. The Abcc6(-/-) and Enpp1(asj) mice were crossed with transgenic mice expressing human ENPP1, an ectonucleotidase which generates PPi from ATP...
June 23, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28652104/quantifying-pelvic-periprosthetic-bone-remodeling-using-dual-energy-x-ray-absorptiometry-region-free-analysis
#18
Andrew M Parker, Lang Yang, Mohsen Farzi, José M Pozo, Alejandro F Frangi, J Mark Wilkinson
The gold standard tool for measuring periprosthetic bone mineral density (BMD) is dual-energy X-ray absorptiometry (DXA). However, resolution of the method is limited due to the aggregation of pixel data into large regions of interest for clinical and statistical analysis. We have previously validated a region-free analysis method (DXA-RFA) for quantitating BMD change at the pixel level around femoral prostheses. Here, we applied the DXA-RFA method to the pelvis, and quantitated its precision in this setting using repeated DXA scans taken on the same day after repositioning in 29 patients after total hip arthroplasty...
June 23, 2017: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/28652048/the-efficacy-of-low-intensity-vibration-to-improve-bone-health-in-patients-with-end-stage-renal-disease-is-highly-dependent-on-compliance-and-muscle-response
#19
Chamith S Rajapakse, Mary B Leonard, Elizabeth A Kobe, Michelle A Slinger, Kelly A Borges, Erica Billig, Clinton T Rubin, Felix W Wehrli
RATIONAL AND OBJECTIVES: Low intensity vibration (LIV) may represent a nondrug strategy to mitigate bone deficits in patients with end-stage renal disease. MATERIALS AND METHODS: Thirty end-stage renal patients on maintenance hemodialysis were randomized to stand for 20 minutes each day on either an active or placebo LIV device. Analysis at baseline and completion of 6-month intervention included magnetic resonance imaging (tibia and fibula stiffness; trabecular thickness, number, separation, bone volume fraction, plate-to-rod ratio; and cortical bone porosity), dual-energy X-ray absorptiometry (hip and spine bone mineral density [BMD]), and peripheral quantitative computed tomography (tibia trabecular and cortical BMD; calf muscle cross-sectional area)...
June 23, 2017: Academic Radiology
https://www.readbyqxmd.com/read/28651948/genetic-sharing-with-coronary-artery-disease-identifies-potential-novel-loci-for-bone-mineral-density
#20
Cheng Peng, Jie Shen, Xu Lin, Kuan-Jui Su, Jonathan Greenbaum, Wei Zhu, Hui-Ling Lou, Feng Liu, Chun-Ping Zeng, Wei-Feng Deng, Hong-Wen Deng
Bone mineral density (BMD) is a complex trait with high missing heritability. Numerous evidences have shown that BMD variation has a relationship with coronary artery disease (CAD). This relationship may come from a common genetic basis called pleiotropy. By leveraging the pleiotropy with CAD, we may be able to improve the detection power of genetic variants associated with BMD. Using a recently developed conditional false discovery rate (cFDR) method, we jointly analyzed summary statistics from two large independent genome wide association studies (GWAS) of lumbar spine (LS) BMD and CAD...
June 23, 2017: Bone
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