keyword
Keywords Molecular markers to predict s...

Molecular markers to predict stroke

https://read.qxmd.com/read/36674749/increase-of-circulating-endothelial-progenitor-cells-and-released-angiogenic-factors-in-children-with-moyamoya-arteriopathy
#21
JOURNAL ARTICLE
Gemma Gorla, Tatiana Carrozzini, Giuliana Pollaci, Antonella Potenza, Sara Nava, Francesco Acerbi, Paolo Ferroli, Silvia Esposito, Veronica Saletti, Emilio Ciusani, Aida Zulueta, Eugenio A Parati, Anna Bersano, Laura Gatti, Ignazio G Vetrano
Moyamoya arteriopathy (MMA) is a rare cerebrovascular disorder that causes recurrent ischemic and hemorrhagic strokes, leading young patients to severe neurological deficits. The pathogenesis of MMA is still unknown. The disease onset in a wide number of pediatric cases raises the question of the role of genetic factors in the disease's pathogenesis. In these patients, MMA's clinical course, or progression, is largely unclear. By performing a comprehensive molecular and cellular profile in the plasma and CSF, respectively, of MMA pediatric patients, our study is aimed at assessing the levels of circulating endothelial progenitor cells (cEPC) and the release of selected proteins at an early disease stage to clarify MMA pathogenesis and progression...
January 8, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/36623995/biomarkers-for-warfighter-safety-and-performance-in-hot-and-cold-environments
#22
REVIEW
Jason K W Lee, Beverly Tan, Boris R M Kingma, François Haman, Yoram Epstein
Exposure to extreme environmental heat or cold during military activities can impose severe thermal strain, leading to impairments in task performance and increasing the risk of exertional heat (including heat stroke) and cold injuries that can be life-threatening. Substantial individual variability in physiological tolerance to thermal stress necessitates an individualized approach to mitigate the deleterious effects of thermal stress, such as physiological monitoring of individual thermal strain. During heat exposure, measurements of deep-body (Tc ) and skin temperatures and heart rate can provide some indication of thermal strain...
December 23, 2022: Journal of Science and Medicine in Sport
https://read.qxmd.com/read/36430226/circulating-inflammatory-biomarkers-in-early-prediction-of-stroke-associated-infections
#23
JOURNAL ARTICLE
Isabel M C Hasse, Gerrit M Grosse, Ramona Schuppner, Till Van Gemmeren, Maria M Gabriel, Karin Weissenborn, Ralf Lichtinghagen, Hans Worthmann
(1) Background: Patients with acute ischaemic stroke (AIS) are at high risk for stroke-associated infections (SAIs). We hypothesised that increased concentrations of systemic inflammation markers predict SAIs and unfavourable outcomes; (2) Methods: In 223 patients with AIS, blood samples were taken at ≤24 h, 3 d and 7d after a stroke, to determine IL-6, IL-10, CRP and LBP. The outcome was assessed using the modified Rankin Scale at 90 d. Patients were thoroughly examined regarding the development of SAIs; (3) Results: 47 patients developed SAIs, including 15 lower respiratory tract infections (LRTIs)...
November 9, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/36348288/x-box-binding-protein-1-as-a-key-modulator-in-healing-endothelial-cells-a-novel-ec-phenotype-promoting-angiogenesis-after-mcao
#24
JOURNAL ARTICLE
Zhuohui Chen, Xiang Wang, Haiyue Wu, Yishu Fan, Zhouyi Yan, Chenxiao Lu, Hongfei Ouyang, Shiyu Zhang, Mengqi Zhang
BACKGROUND: Endothelial cells (ECs) play an important role in angiogenesis and vascular reconstruction in the pathophysiology of ischemic stroke. Previous investigations have provided a profound cerebral vascular atlas under physiological conditions, but have failed to identify new disease-related cell subtypes. We aimed to identify new EC subtypes and determine the key modulator genes. METHODS: Two datasets GSE174574 and GSE137482 were included in the study. Seurat was utilized as the standard quality-control pipeline...
November 8, 2022: Cellular & Molecular Biology Letters
https://read.qxmd.com/read/36227679/bioinformatic-prediction-of-depression-related-signaling-pathways-regulated-by-mir-146a-in-peripheral-blood-of-patients-with-post-stroke-depression
#25
JOURNAL ARTICLE
Zhimin Chen, Na Wang, Risu Na, Haiyan Yu, Dan Sui, Bing Cui, Lihua Wang
It was aimed to explore the differential expression of miR-146a-5p in peripheral blood of patients with post-stroke depression (PSD), and to analyze its mechanism using bioinformatics. Stroke patients were selected as the research objects, and were divided into PSD ones and non-post-stroke depression (N-PSD) ones with the National Institutes of Health stroke scale (NHISS) and Hamilton Depression Scale-17 terms (HAMD-17) scores. Peripheral blood of patients was collected for serum miR-146a-5p detection. Targetscan7...
June 30, 2022: Cellular and Molecular Biology
https://read.qxmd.com/read/36211422/identification-of-immune-cell-infiltration-and-diagnostic-biomarkers-in-unstable-atherosclerotic-plaques-by-integrated-bioinformatics-analysis-and-machine-learning
#26
JOURNAL ARTICLE
Jing Wang, Zijian Kang, Yandong Liu, Zifu Li, Yang Liu, Jianmin Liu
Objective: The decreased stability of atherosclerotic plaques increases the risk of ischemic stroke. However, the specific characteristics of dysregulated immune cells and effective diagnostic biomarkers associated with stability in atherosclerotic plaques are poorly characterized. This research aims to investigate the role of immune cells and explore diagnostic biomarkers in the formation of unstable plaques for the sake of gaining new insights into the underlying molecular mechanisms and providing new perspectives for disease detection and therapy...
2022: Frontiers in Immunology
https://read.qxmd.com/read/36187340/identification-of-monocyte-associated-genes-related-to-the-instability-of-atherosclerosis-plaque
#27
JOURNAL ARTICLE
Wentao Qin, Fu Gan, Riguan Liang, Jing Li, Xiaomei Lai, Yongfa Dai, Jie Liu
Background: Atherosclerotic plaque instability is a common cause of stroke and ischemic infarction, and identification of monocyte-associated genes has become a prominent feature in cardiovascular research as a contributing/predictive marker. Methods: Whole genome sequencing data were downloaded from GSE159677, GSE41571, GSE120521, and GSE118481. Single-cell sequencing data analysis was conducted to cluster molecular subtypes of atherosclerotic plaques and identify specific genes...
2022: Oxidative Medicine and Cellular Longevity
https://read.qxmd.com/read/36142524/selected-mediators-of-inflammation-in-patients-with-acute-ischemic-stroke
#28
JOURNAL ARTICLE
Hanna Pawluk, Renata Kołodziejska, Grzegorz Grześk, Mariusz Kozakiewicz, Alina Woźniak, Mateusz Pawluk, Agnieszka Kosinska, Magdalena Grześk, Jakub Wojtasik, Grzegorz Kozera
During a stroke, a series of biochemical and metabolic changes occur which eventually lead to the death of cells by necrosis or apoptosis. This is a multi-stage process involving oxidative stress and an inflammatory response from the first signs of occlusion of a blood vessel until the late stages of regeneration and healing of ischemic tissues. The purpose of the research was to assess the concentration of pro-inflammatory cytokines IL-6 and TNF-α in the blood serum of patients with ischemic stroke (AIS) and to investigate their role as new markers in predicting functional prognosis after thrombolytic therapy...
September 13, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/36077361/ccl5-levels-predict-stroke-volume-growth-in-acute-ischemic-stroke-and-significantly-diminish-in-hemorrhagic-stroke-patients
#29
JOURNAL ARTICLE
Francisco José Julián-Villaverde, Marta Serrano-Ponz, Enrique Ramalle-Gómara, Alfredo Martínez, Laura Ochoa-Callejero
Stroke remains an important health challenge. Here, we study whether circulating chemokine (C-C motif) ligand 5 (CCL5) levels may predict clinical outcomes for stroke patients. A total of 100 consecutive stroke patients (36 acute ischemic and 64 hemorrhagic) were admitted to the stroke unit. Clinical history data and monitoring parameters were recorded. Blood serum was collected at days 0, 1, and hospital discharge to measure CCL5 levels by ELISA. Infarct or hemorrhagic volume, neurological severity (NIHSS), and functional prognosis (mRankin scale) were measured as clinical outcomes...
September 1, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/36027040/long-noncoding-rna-neat1-expression-and-its-target-mir-124-in-diabetic-ischemic-stroke-patients
#30
JOURNAL ARTICLE
Rehab A Karam, Mona M Amer, Haidy E Zidan
Background: Diabetes mellitus is a known risk factor for stroke and may be linked to poorer post-stroke outcomes. However, the underlying molecular mechanisms remain to be fully identified. In this study we assessed the association of the lncRNA Nuclear enriched abundant transcript 1 ( NEAT1 )'s expression and its target miRNA-124 with acute ischemic stroke (AIS) in type II diabetic patients (T2DM). Methods and Results: Diabetic patients with stroke, non-diabetics with stroke, diabetics without stroke, and controls were recruited...
July 2022: Genetic Testing and Molecular Biomarkers
https://read.qxmd.com/read/35960412/matrix-metalloproteinase-3-and-9-as-genetic-biomarkers-for-the-occurrence-of-cardiovascular-complications-in-coronary-artery-disease-a-prospective-cohort-study
#31
JOURNAL ARTICLE
Imen Guizani, Wiem Zidi, Yosra Zayani, Fourti Nesrine, Hayet Douik, Haifa Sanhaji, Mohamed Sami Mourali, Moncef Feki, Monia Allal-Elasmi
BACKGROUND: Matrix metalloproteinases (MMPs) are widely expressed in atherosclerosis lesions. The disequilibrium of MMPs driving to an overexpression or a lack of its level can be influenced by genetic variations. MMP-3 and MMP-9 may be affected by specific polymorphisms like - 1612 5 A/6A and the - 1562 C/T respectively. We aim in the present study to investigate prospectively the association between the - 1612 5 A/6A MMP-3 and - 1562 C/T MMP-9 polymorphisms and clinical outcomes in patients with coronary artery disease (CAD)...
August 12, 2022: Molecular Biology Reports
https://read.qxmd.com/read/35927640/high-frequency-repetitive-transcranial-magnetic-stimulation-rtms-protects-against-ischemic-stroke-by-inhibiting-m1-microglia-polarization-through-let-7b-5p-hmga2-nf-%C3%AE%C2%BAb-signaling-pathway
#32
JOURNAL ARTICLE
Ye Hong, Jinfeng Lyu, Lin Zhu, Xixi Wang, Mengna Peng, Xiangliang Chen, Qiwen Deng, Jie Gao, Zhenhua Yuan, Di Wang, Gelin Xu, Mengyi Xu
BACKGROUND: Microglia assume opposite phenotypes in response to ischemic brain injury, exerting neurotoxic and neuroprotective effects under different ischemic stages. Modulating M1/M2 polarization is a potential therapy for treating ischemic stroke. Repetitive transcranial magnetic stimulation (rTMS) held the capacity to regulate neuroinflammation and astrocytic polarization, but little is known about rTMS effects on microglia. Therefore, the present study aimed to examine the rTMS influence on microglia polarization and the underlying possible molecular mechanisms in ischemic stroke models...
August 4, 2022: BMC Neuroscience
https://read.qxmd.com/read/35479288/antibodies-against-phosphorylcholine-among-60-year-olds-clinical-role-and-simulated-interactions
#33
JOURNAL ARTICLE
Shailesh Kumar Samal, Pritam Kumar Panda, Max Vikström, Karin Leander, Ulf de Faire, Rajeev Ahuja, Johan Frostegård
Aims: Antibodies against phosphorylcholine (anti-PC) are implicated as protection markers in atherosclerosis, cardiovascular disease (CVD), and other chronic inflammatory conditions. Mostly, these studies have been focused on IgM. In this study, we determined IgG, IgG1, and IgG2 anti-PC among 60-year-olds. Methods: Based on a 7-year follow-up of 60-year-olds (2,039 men and 2,193 women) from Stockholm County, we performed a nested case-control study of 209 incident CVD cases with 620 age- and sex-matched controls...
2022: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/35345408/-eucommia-ulmoides-oliver-tribulus-terrestris-l-drug-pair-regulates-ferroptosis-by-mediating-the-neurovascular-related-ligand-receptor-interaction-pathway-a-potential-drug-pair-for-treatment-hypertension-and-prevention-ischemic-stroke
#34
JOURNAL ARTICLE
Qian Zhang, Jie Yang, Chuanhua Yang, Xuesong Yang, Yongzhi Chen
Background: In this study, we used the network pharmacology approach to explore the potential disease targets of the Eucommia ulmoides Oliver (EUO)- Tribulus terrestris L. (TT) drug pair in the treatment of hypertension-associated neurovascular lesions and IS via the ferroptosis pathway. Methods: We used the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform to search for the key active compounds and targets of the drug pair. Based on the GeneCards database, the relevant targets for the drug pair were obtained...
2022: Frontiers in Neurology
https://read.qxmd.com/read/34972714/infrared-spectroscopic-study-and-mathematical-simulations-of-carotid-atherosclerosis
#35
JOURNAL ARTICLE
Jane Anastassopoulou, Vasiliki Mamareli, Evangelos Mylonas, Panagiota Kolovou, Ioannis Mamarelis, Christophoros Kotoulas, Christina Mamareli, Sotiris Kotoulas, Emmanouil Koutoulakis, Konstantinos Spiliopoulos, Theophile Theophanides
BACKGROUND/AIM: The pathogenesis, treatment and prevention of atherosclerosis continue to be the subject of intensive research and study by the scientific community. Based on Fourier-transform infrared spectra and 3D-Doppler echogram, we attempted to develop a computational simulation model for predicting the association of atherosclerotic risk factors with pathogenic molecular structural changes. MATERIALS AND METHODS: Atheromatic carotid arteries from 56 patients (60-85 years old) were used as samples...
January 2022: In Vivo
https://read.qxmd.com/read/34733163/buqitongluo-granule-for-ischemic-stroke-stable-angina-pectoris-diabetic-peripheral-neuropathy-with-qi-deficiency-and-blood-stasis-syndrome-rationale-and-novel-basket-design
#36
REVIEW
Weidi Liu, Li Zhou, Luda Feng, Dandan Zhang, Chi Zhang, Ying Gao
Background: BuqiTongluo (BQTL) granules are herbal phenotypic drugs for Qi deficiency and blood stasis (QDBS) syndrome. Its discovery relied primarily on knowledge of observable phenotypic changes associated with diseases. Although BQTL granules have been widely advocated by Chinese Medicine (CM) practitioners, its use lacks empirical support. Aim of the study: In this basket trial, the efficacy of BQTL granules in multiple diseases that have the QDBS syndrome in common will be compared with placebo. Materials and Methods: The BuqiTongluo granule for Qi deficiency and blood stasis syndrome (BOSS) study is a basket herbal trial (ClinicalTrials...
2021: Frontiers in Pharmacology
https://read.qxmd.com/read/34630278/imaging-acute-stroke-from-one-size-fit-all-to-biomarkers
#37
REVIEW
Jianfei Lu, Qiyong Mei, Xianhua Hou, Anatol Manaenko, Lili Zhou, David S Liebeskind, John H Zhang, Yao Li, Qin Hu
In acute stroke management, time window has been rigidly used as a guide for decades and the reperfusion treatment is only available in the first few limited hours. Recently, imaging-based selection of patients has successfully expanded the treatment window out to 16 and even 24 h in the DEFUSE 3 and DAWN trials, respectively. Recent guidelines recommend the use of imaging techniques to guide therapeutic decision-making and expanded eligibility in acute ischemic stroke. A tissue window is proposed to replace the time window and serve as the surrogate marker for potentially salvageable tissue...
2021: Frontiers in Neurology
https://read.qxmd.com/read/34445740/the-role-of-biomarkers-in-atherothrombotic-stroke-a-systematic-review
#38
REVIEW
Sebastian Andone, Zoltan Bajko, Anca Motataianu, Oana Mosora, Rodica Balasa
Stroke represents the primary debilitating disease in adults and is the second-highest cause of death worldwide. Atherosclerosis, the most prevalent etiology for vascular conditions, is a continuous process that gradually creates and develops endothelial lesions known as atherosclerotic plaques. These lesions lead to the appearance of atherothrombotic stroke. In the last decades, the role of biological biomarkers has emerged as either diagnostic, prognostic, or therapeutic targets. This article aims to create a list of potential biomarkers related to atherothrombotic stroke by reviewing the currently available literature...
August 21, 2021: International Journal of Molecular Sciences
https://read.qxmd.com/read/34389283/prognostic-molecular-markers-for-motor-recovery-in-acute-hemorrhagic-stroke-a-systematic-review
#39
REVIEW
Jean Alex Matos Ribeiro, Luisa Fernanda García-Salazar, Cássia Regina Saade-Pacheco, Érika Shirley Moreira Silva, Simone Garcia Oliveira, Ana Flávia Silveira, Adriana Sanches Garcia-Araújo, Thiago Luiz Russo
BACKGROUND AND AIMS: Molecular biomarkers are associated with poor prognosis in ischemic stroke individuals. However, it might not be generalizable to post-acute hemorrhagic stroke since the underlying mechanisms of this brain damage differ from those found in ischemic stroke. The main purpose of this review was to synthesize the potential predictive molecular biomarkers for motor recovery following acute hemorrhagic stroke. MATERIALS AND METHODS: An electronic search was conducted by 2 independent reviewers in the following databases: PubMed (Medline), EMBASE, Web of Science, and CINAHL...
November 2021: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://read.qxmd.com/read/34277733/a-review-of-biomarkers-for-ischemic-stroke-evaluation-in-patients-with-non-valvular-atrial-fibrillation
#40
REVIEW
Luxiang Shang, Ling Zhang, Yankai Guo, Huaxin Sun, Xiaoxue Zhang, Yakun Bo, Xianhui Zhou, Baopeng Tang
Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia worldwide and results in a significantly increased ischemic stroke (IS) risk. IS risk stratification tools are widely being applied to guide anticoagulation treatment decisions and duration in patients with non-valvular AF (NVAF). The CHA2 DS2 -VASc score is largely validated and currently recommended by renowned guidelines. However, this score is heavily dependent on age, sex, and comorbidities, and exhibits only moderate predictive power. Finding effective and validated clinical biomarkers to assist in personalized IS risk evaluation has become one of the promising directions in the prevention and treatment of NVAF...
2021: Frontiers in Cardiovascular Medicine
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